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-childhood cancer survivor cohort late effect

Chelsea Anderson, Andrew B Smitherman, Stephanie M Engel, Hazel B Nichols
PURPOSE: A cancer diagnosis in adolescence and young adulthood (AYA, ages 15-39) may affect future pregnancy outcomes. Previous studies have reported an increased risk of preterm delivery (< 37 weeks of gestation) after maternal cancer treatment. In this analysis, we evaluated whether non-cancer characteristics modify the association between an AYA cancer history and preterm birth. METHODS: North Carolina Central Cancer Registry records (2000-2013) were linked to state birth certificate files (2000-2014) to identify births to AYA cancer survivors (n = 1,980)...
December 1, 2017: Cancer Causes & Control: CCC
Michael Paul Foley, Scott Michael Hasson, Eydie Kendall
The purpose of this investigation was 2-fold: (1) to investigate the effects of a translational 12-week community-based multimodal exercise program on quality of life (QoL) in breast cancer survivors (BCS) and (2) to examine the influence of a start delay on physical function and QoL in BCS. Fifty-two female BCS completed a 12-week program consisting of 90-minute supervised exercise sessions at a frequency of 2 supervised sessions per week. Exercise sessions consisted of three 30-minute components: (1) aerobic conditioning, (2) resistance exercise training, and (3) balance and flexibility training...
September 1, 2017: Integrative Cancer Therapies
Line M H Schack, Stine E Petersen, Steffen Nielsen, Lilly Lundby, Morten Høyer, Lise Bentzen, Jens Overgaard, Christian N Andreassen, Jan Alsner
INTRODUCTION: Normal tissue morbidity sets the dose limit for radiotherapy (RT) in cancer treatment and has importance for quality of life for cancer survivors. A previous study of prostate cancer patients treated with RT generated clinical data for radiation-induced morbidity measured by anorectal physiological methods and validated questionnaires. Other studies have identified genetic predictors associated with late radiation-induced morbidity outcome. We have expanded biobank material aiming to validate single nucleotide polymorphisms (SNPs) and a gene expression classifier with endpoints on patient-reported outcomes and biomechanical properties of the anorectum from our cohort matching originally published endpoints...
November 2017: Acta Oncologica
Ruth T Morin, Elizabeth Midlarsky
OBJECTIVE: To investigate whether treatment of cancer with chemotherapy, as compared with surgery and radiation, differentially affects cognitive functioning in older adults. DESIGN: Latent class growth analysis approach. SETTING: Health and Retirement Study. PARTICIPANTS: Older adults (N=403) with a new diagnosis of cancer who were still alive 4 years after their diagnosis. INTERVENTIONS: Not applicable...
July 20, 2017: Archives of Physical Medicine and Rehabilitation
Theresa H M Keegan, Archie Bleyer, Aaron S Rosenberg, Qian Li, Melanie Goldfarb
Importance: Although the increased incidence of second primary malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared survival after an SPM to survival of the same cancer occurring as first primary malignant neoplasm (PM) by age. Objective: To assess the survival impact of SPMs in adolescents and young adults (AYAs) (15-39 years) compared with that of pediatric (<15 years) and older adult (≥40 years) patients with the same SPMs...
November 1, 2017: JAMA Oncology
Gunnar Steineck, Viktor Skokic, Fei Sjöberg, Cecilia Bull, Eleftheria Alevronta, Gail Dunberger, Karin Bergmark, Ulrica Wilderäng, Jung Hun Oh, Joseph O Deasy, Rebecka Jörnsten
BACKGROUND: During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. METHODS: Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health...
2017: PloS One
Talya Salz, Mary S McCabe, Kevin C Oeffinger, Stacie Corcoran, Andrew J Vickers, Andrew L Salner, Ellen Dornelas, Rebecca Schnall, Nirupa J Raghunathan, Elizabeth Fortier, Shrujal S Baxi
BACKGROUND: Head and neck cancer survivors commonly experience severe long-term toxicities, late-occurring symptoms, and significant risks of the second primary malignancy and comorbid illnesses. With multiple simultaneous health issues, these complex cancer survivors often do not receive comprehensive health care that addresses their needs. A tool is needed to streamline and standardize comprehensive care for this cohort. METHODS/DESIGN: We designed the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR) to address health care challenges for head and neck cancer survivors...
2016: Pilot and Feasibility Studies
Daniela Hladik, Soile Tapio
Epidemiological studies on the atomic-bomb survivors, cancer survivors and occupational cohorts provide strong evidence for multifaceted damage to brain after ionizing radiation. Radiation-induced late effects may manifest as brain tumors or cognitive impairment. Decreased neurogenesis and differentiation, alteration in neural structure and synaptic plasticity as well as increased oxidative stress and inflammation are suggested to contribute to adverse effects in the brain. In addition to neural stems cells, several brain-specific mature cell types including endothelial and glial cells are negatively affected by ionizing radiation...
October 2016: Mutation Research
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
Sarah L Kerns, Leila Dorling, Laura Fachal, Søren Bentzen, Paul D P Pharoah, Daniel R Barnes, Antonio Gómez-Caamaño, Ana M Carballo, David P Dearnaley, Paula Peleteiro, Sarah L Gulliford, Emma Hall, Kyriaki Michailidou, Ángel Carracedo, Michael Sia, Richard Stock, Nelson N Stone, Matthew R Sydes, Jonathan P Tyrer, Shahana Ahmed, Matthew Parliament, Harry Ostrer, Barry S Rosenstein, Ana Vega, Neil G Burnet, Alison M Dunning, Gillian C Barnett, Catharine M L West
Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test predicting risk of toxicity could benefit many cancer patients. We aimed to meta-analyze individual level data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic markers of toxicity. Prospectively assessed two-year toxicity endpoints (urinary frequency, decreased urine stream, rectal bleeding, overall toxicity) and single nucleotide polymorphism (SNP) associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors...
August 2016: EBioMedicine
Ryne J DeBo, Cynthia J Lees, Greg O Dugan, David L Caudell, Kris T Michalson, David B Hanbury, Kylie Kavanagh, J Mark Cline, Thomas C Register
Heart disease is an increasingly recognized, serious late effect of radiation exposure, most notably among breast cancer and Hodgkin's disease survivors, as well as the Hiroshima and Nagasaki atomic bomb survivors. The purpose of this study was to evaluate the late effects of total-body irradiation (TBI) on cardiac morphology, function and selected circulating biomarkers in a well-established nonhuman primate model. For this study we used male rhesus macaques that were exposed to a single total-body dose of ionizing gamma radiation (6...
July 2016: Radiation Research
Mia Hashibe, Sarah Abdelaziz, Mohammed Al-Temimi, Alison Fraser, Kenneth M Boucher, Ken Smith, Yuan-Chin Amy Lee, Kerry Rowe, Braden Rowley, Micky Daurelle, Avery E Holton, James VanDerslice, Lorenzo Richiardi, Jay Bishoff, Will Lowrance, Antoinette Stroup
PURPOSE: Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. Our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. METHODS: We conducted a population-based cohort study of testicular cancer survivors, diagnosed 1991-2007, followed up for a median of 10 years. We identified 785 testicular cancer patients who survived ≥5 years and 3323 men free of cancer for the comparison group...
December 2016: Journal of Cancer Survivorship: Research and Practice
Andrew J Rosko, Matthew E Spector, Garrett R Griffin, Jeffrey M Vainshtein, Jae Lee, Carol R Bradford, Mark E P Prince, Jeffrey S Moyer, Francis P Worden, Avraham Eisbruch, Douglas B Chepeha
BACKGROUND: Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. METHODS: We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy...
August 2016: Head & Neck
Charlene Rae, Ann Benger, Jo-Ann Fowler, Janet MacEachern, Eleanor Pullenayegum, Michelle Stryker, Ronald D Barr
PURPOSE: Hodgkin lymphoma (HL) is the commonest cancer in adolescents and young adults (AYAs), aged 15-29 years. While the survival rate is high, many survivors experience adverse late effects of therapy. Yet, this age group in general makes limited use of health services. This study sought to determine whether the need for health services by HL survivors was mismatched to their health service utilization, as hypothesized a priori. METHODS: A population-based cohort of survivors (N = 43) younger than 39 years of age was sent a mailed survey for self-assessment of need, as expressed in health-related quality of life (HRQOL), and utilization of health services by validated instruments; the Health Utilities Index and Health and Social Service Utilization Survey, respectively...
June 2016: Journal of Adolescent and Young Adult Oncology
Raffaella Marcheselli, Luigi Marcheselli, Laura Cortesi, Alessia Bari, Claudia Cirilli, Samantha Pozzi, Paola Ferri, Martina Napolitano, Massimo Federico, Stefano Sacchi
PURPOSE: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. METHODS: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women...
December 2015: Journal of Breast Cancer
Michael Schaapveld, Berthe M P Aleman, Anna M van Eggermond, Cécile P M Janus, Augustinus D G Krol, Richard W M van der Maazen, Judith Roesink, John M M Raemaekers, Jan Paul de Boer, Josée M Zijlstra, Gustaaf W van Imhoff, Eefke J Petersen, Philip M P Poortmans, Max Beijert, Marnix L Lybeert, Ina Mulder, Otto Visser, Marieke W J Louwman, Inge M Krul, Pieternella J Lugtenburg, Flora E van Leeuwen
BACKGROUND: Survivors of Hodgkin's lymphoma are at increased risk for treatment-related subsequent malignant neoplasms. The effect of less toxic treatments, introduced in the late 1980s, on the long-term risk of a second cancer remains unknown. METHODS: We enrolled 3905 persons in the Netherlands who had survived for at least 5 years after the initiation of treatment for Hodgkin's lymphoma. Patients had received treatment between 1965 and 2000, when they were 15 to 50 years of age...
December 24, 2015: New England Journal of Medicine
Kathrine Rugbjerg, Jørgen H Olsen
IMPORTANCE: Survivors of adolescent and young adult cancers are at risk for treatment-induced late adverse effects; however, to our knowledge, the long-term risk of hospitalization in this specific group of cancer survivors has not been thoroughly evaluated. OBJECTIVE: To examine relative and absolute excess risk for hospitalizations up to 34 years after diagnosis of adolescent and young adult cancer compared with population comparisons. DESIGN, SETTING, AND PARTICIPANTS: This was a cohort study, conducted in Denmark, of 33,555 five-year survivors of adolescent or young adult cancer, diagnosed from 1943 through 2004, when they were 15 to 39 years of age, and 228,447 population comparisons, matched to the survivors by sex and year of birth...
February 2016: JAMA Oncology
Hart A Goldhar, Andrew T Yan, Dennis T Ko, Craig C Earle, George A Tomlinson, Maureen E Trudeau, Murray D Krahn, Monika K Krzyzanowska, Raveen S Pal, Christine Brezden-Masley, Scott Gavura, Kelly Lien, Kelvin K W Chan
BACKGROUND: The late cardiac effect of adjuvant trastuzumab and its potential interaction with anthracycline have not been well-studied on a population level. METHODS: In this retrospective population-based cohort study, female breast cancer patients in Ontario, diagnosed between 2003 and 2009, were identified by the Ontario Cancer Registry and linked to administrative databases to ascertain demographics, cardiac risk factors, comorbidities, and use of adjuvant trastuzumab and other chemotherapy...
January 2016: Journal of the National Cancer Institute
Eric J Grant, Kyoji Furukawa, Ritsu Sakata, Hiromi Sugiyama, Atsuko Sadakane, Ikuno Takahashi, Mai Utada, Yukiko Shimizu, Kotaro Ozasa
BACKGROUND: No clear epidemiological hereditary effects of radiation exposure in human beings have been reported. However, no previous studies have investigated mortality into middle age in a population whose parents were exposed to substantial amounts of radiation before conception. We assessed mortality in children of the atomic bomb survivors after 62 years of follow-up. METHODS: In this prospective cohort study, we assessed 75 327 singleton children of atomic bomb survivors in Hiroshima and Nagasaki and unexposed controls, born between 1946 and 1984, and followed up to Dec 31, 2009...
October 2015: Lancet Oncology
M J Ehrhardt, R Brazauskas, W He, J D Rizzo, B E Shaw
Allogeneic hematopoietic cell transplantation is associated with late adverse effects of therapy, including secondary solid cancers. Most reports address risk factors; however, outcomes after secondary solid cancer development are incompletely described. Our objective was to estimate survival probabilities for transplant recipients dependent on secondary solid cancer subtype. We used a previously identified and published cohort who developed secondary solid cancers following allogeneic transplant. Follow-up for these 112 previously identified patients was extended and their survival probabilities were studied...
January 2016: Bone Marrow Transplantation
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