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https://www.readbyqxmd.com/read/27906782/predicting-heart-dose-in-breast-cancer-patients-who-received-3d-conformal-radiation-therapy
#1
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27515689/meta-analysis-of-genome-wide-association-studies-identifies-genetic-markers-of-late-toxicity-following-radiotherapy-for-prostate-cancer
#2
Sarah L Kerns, Leila Dorling, Laura Fachal, Søren Bentzen, Paul D P Pharoah, Daniel R Barnes, Antonio Gómez-Caamaño, Ana M Carballo, David P Dearnaley, Paula Peleteiro, Sarah L Gulliford, Emma Hall, Kyriaki Michailidou, Ángel Carracedo, Michael Sia, Richard Stock, Nelson N Stone, Matthew R Sydes, Jonathan P Tyrer, Shahana Ahmed, Matthew Parliament, Harry Ostrer, Barry S Rosenstein, Ana Vega, Neil G Burnet, Alison M Dunning, Gillian C Barnett, Catharine M L West
Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test predicting risk of toxicity could benefit many cancer patients. We aimed to meta-analyze individual level data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic markers of toxicity. Prospectively assessed two-year toxicity endpoints (urinary frequency, decreased urine stream, rectal bleeding, overall toxicity) and single nucleotide polymorphism (SNP) associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors...
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27333082/late-effects-of-total-body-gamma-irradiation-on-cardiac-structure-and-function-in-male-rhesus-macaques
#3
Ryne J DeBo, Cynthia J Lees, Greg O Dugan, David L Caudell, Kris T Michalson, David B Hanbury, Kylie Kavanagh, J Mark Cline, Thomas C Register
Heart disease is an increasingly recognized, serious late effect of radiation exposure, most notably among breast cancer and Hodgkin's disease survivors, as well as the Hiroshima and Nagasaki atomic bomb survivors. The purpose of this study was to evaluate the late effects of total-body irradiation (TBI) on cardiac morphology, function and selected circulating biomarkers in a well-established nonhuman primate model. For this study we used male rhesus macaques that were exposed to a single total-body dose of ionizing gamma radiation (6...
July 2016: Radiation Research
https://www.readbyqxmd.com/read/27169992/long-term-health-effects-among-testicular-cancer-survivors
#4
Mia Hashibe, Sarah Abdelaziz, Mohammed Al-Temimi, Alison Fraser, Kenneth M Boucher, Ken Smith, Yuan-Chin Amy Lee, Kerry Rowe, Braden Rowley, Micky Daurelle, Avery E Holton, James VanDerslice, Lorenzo Richiardi, Jay Bishoff, Will Lowrance, Antoinette Stroup
PURPOSE: Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. Our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. METHODS: We conducted a population-based cohort study of testicular cancer survivors, diagnosed 1991-2007, followed up for a median of 10 years. We identified 785 testicular cancer patients who survived ≥5 years and 3323 men free of cancer for the comparison group...
December 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27080049/neurologic-late-effects-associated-with-radiologic-evidence-of-vertebral-osteoradionecrosis-after-salvage-laryngectomy-a-syndrome-associated-with-survivors-of-laryngeal-and-hypopharyngeal-cancer
#5
Andrew J Rosko, Matthew E Spector, Garrett R Griffin, Jeffrey M Vainshtein, Jae Lee, Carol R Bradford, Mark E P Prince, Jeffrey S Moyer, Francis P Worden, Avraham Eisbruch, Douglas B Chepeha
BACKGROUND: Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. METHODS: We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy...
August 2016: Head & Neck
https://www.readbyqxmd.com/read/26812460/need-and-use-of-healthcare-services-in-survivors-of-hodgkin-lymphoma
#6
Charlene Rae, Ann Benger, Jo-Ann Fowler, Janet MacEachern, Eleanor Pullenayegum, Michelle Stryker, Ronald D Barr
PURPOSE: Hodgkin lymphoma (HL) is the commonest cancer in adolescents and young adults (AYAs), aged 15-29 years. While the survival rate is high, many survivors experience adverse late effects of therapy. Yet, this age group in general makes limited use of health services. This study sought to determine whether the need for health services by HL survivors was mismatched to their health service utilization, as hypothesized a priori. METHODS: A population-based cohort of survivors (N = 43) younger than 39 years of age was sent a mailed survey for self-assessment of need, as expressed in health-related quality of life (HRQOL), and utilization of health services by validated instruments; the Health Utilities Index and Health and Social Service Utilization Survey, respectively...
June 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/26770245/risk-of-second-primary-malignancy-in-breast-cancer-survivors-a-nested-population-based-case-control-study
#7
Raffaella Marcheselli, Luigi Marcheselli, Laura Cortesi, Alessia Bari, Claudia Cirilli, Samantha Pozzi, Paola Ferri, Martina Napolitano, Massimo Federico, Stefano Sacchi
PURPOSE: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. METHODS: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women...
December 2015: Journal of Breast Cancer
https://www.readbyqxmd.com/read/26699166/second-cancer-risk-up-to-40-years-after-treatment-for-hodgkin-s-lymphoma
#8
Michael Schaapveld, Berthe M P Aleman, Anna M van Eggermond, Cécile P M Janus, Augustinus D G Krol, Richard W M van der Maazen, Judith Roesink, John M M Raemaekers, Jan Paul de Boer, Josée M Zijlstra, Gustaaf W van Imhoff, Eefke J Petersen, Philip M P Poortmans, Max Beijert, Marnix L Lybeert, Ina Mulder, Otto Visser, Marieke W J Louwman, Inge M Krul, Pieternella J Lugtenburg, Flora E van Leeuwen
BACKGROUND: Survivors of Hodgkin's lymphoma are at increased risk for treatment-related subsequent malignant neoplasms. The effect of less toxic treatments, introduced in the late 1980s, on the long-term risk of a second cancer remains unknown. METHODS: We enrolled 3905 persons in the Netherlands who had survived for at least 5 years after the initiation of treatment for Hodgkin's lymphoma. Patients had received treatment between 1965 and 2000, when they were 15 to 50 years of age...
December 24, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26584448/long-term-risk-of-hospitalization-for-somatic-diseases-in-survivors-of-adolescent-or-young-adult-cancer
#9
Kathrine Rugbjerg, Jørgen H Olsen
IMPORTANCE: Survivors of adolescent and young adult cancers are at risk for treatment-induced late adverse effects; however, to our knowledge, the long-term risk of hospitalization in this specific group of cancer survivors has not been thoroughly evaluated. OBJECTIVE: To examine relative and absolute excess risk for hospitalizations up to 34 years after diagnosis of adolescent and young adult cancer compared with population comparisons. DESIGN, SETTING, AND PARTICIPANTS: This was a cohort study, conducted in Denmark, of 33,555 five-year survivors of adolescent or young adult cancer, diagnosed from 1943 through 2004, when they were 15 to 39 years of age, and 228,447 population comparisons, matched to the survivors by sex and year of birth...
February 2016: JAMA Oncology
https://www.readbyqxmd.com/read/26476433/the-temporal-risk-of-heart-failure-associated-with-adjuvant-trastuzumab-in-breast-cancer-patients-a-population-study
#10
Hart A Goldhar, Andrew T Yan, Dennis T Ko, Craig C Earle, George A Tomlinson, Maureen E Trudeau, Murray D Krahn, Monika K Krzyzanowska, Raveen S Pal, Christine Brezden-Masley, Scott Gavura, Kelly Lien, Kelvin K W Chan
BACKGROUND: The late cardiac effect of adjuvant trastuzumab and its potential interaction with anthracycline have not been well-studied on a population level. METHODS: In this retrospective population-based cohort study, female breast cancer patients in Ontario, diagnosed between 2003 and 2009, were identified by the Ontario Cancer Registry and linked to administrative databases to ascertain demographics, cardiac risk factors, comorbidities, and use of adjuvant trastuzumab and other chemotherapy...
January 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26384241/risk-of-death-among-children-of-atomic-bomb-survivors-after-62-years-of-follow-up-a-cohort-study
#11
Eric J Grant, Kyoji Furukawa, Ritsu Sakata, Hiromi Sugiyama, Atsuko Sadakane, Ikuno Takahashi, Mai Utada, Yukiko Shimizu, Kotaro Ozasa
BACKGROUND: No clear epidemiological hereditary effects of radiation exposure in human beings have been reported. However, no previous studies have investigated mortality into middle age in a population whose parents were exposed to substantial amounts of radiation before conception. We assessed mortality in children of the atomic bomb survivors after 62 years of follow-up. METHODS: In this prospective cohort study, we assessed 75 327 singleton children of atomic bomb survivors in Hiroshima and Nagasaki and unexposed controls, born between 1946 and 1984, and followed up to Dec 31, 2009...
October 2015: Lancet Oncology
https://www.readbyqxmd.com/read/26367222/survival-of-patients-who-develop-solid-tumors-following-hematopoietic-stem-cell-transplantation
#12
M J Ehrhardt, R Brazauskas, W He, J D Rizzo, B E Shaw
Allogeneic hematopoietic cell transplantation is associated with late adverse effects of therapy, including secondary solid cancers. Most reports address risk factors; however, outcomes after secondary solid cancer development are incompletely described. Our objective was to estimate survival probabilities for transplant recipients dependent on secondary solid cancer subtype. We used a previously identified and published cohort who developed secondary solid cancers following allogeneic transplant. Follow-up for these 112 previously identified patients was extended and their survival probabilities were studied...
January 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/26251392/long-term-effects-of-radiation-exposure-on-health
#13
REVIEW
Kenji Kamiya, Kotaro Ozasa, Suminori Akiba, Ohstura Niwa, Kazunori Kodama, Noboru Takamura, Elena K Zaharieva, Yuko Kimura, Richard Wakeford
Late-onset effects of exposure to ionising radiation on the human body have been identified by long-term, large-scale epidemiological studies. The cohort study of Japanese survivors of the atomic bombings of Hiroshima and Nagasaki (the Life Span Study) is thought to be the most reliable source of information about these health effects because of the size of the cohort, the exposure of a general population of both sexes and all ages, and the wide range of individually assessed doses. For this reason, the Life Span Study has become fundamental to risk assessment in the radiation protection system of the International Commission on Radiological Protection and other authorities...
August 1, 2015: Lancet
https://www.readbyqxmd.com/read/26194049/second-primary-malignancies-after-radiotherapy-including-hdr-252-cf-brachytherapy-for-cervical-cancer
#14
Vitalija Samerdokiene, Konstantinas Povilas Valuckas, Ernestas Janulionis, Vydmantas Atkocius, Mark J Rivard
PURPOSE: Second primary malignancies (SPMs) are among the most serious late adverse effects after radiotherapy experienced over time by the increasing population of cancer survivors worldwide. The study aim was to determine the rate and distribution of SPMs for neutron- and photon-emitting brachytherapy (BT) sources for patients treated for cervical cancer. METHODS AND MATERIALS: The cohort comprised 662 patients with invasive cervical cancer (Stages IIB and IIIB) and contributed 5,224 patient-years (PY) of observation...
November 2015: Brachytherapy
https://www.readbyqxmd.com/read/26169617/hospitalization-rates-among-survivors-of-young-adult-malignancies
#15
Devon P Richardson, Corinne Daly, Rinku Sutradhar, Lawrence F Paszat, Andrew S Wilton, Linda Rabeneck, Nancy N Baxter
PURPOSE: There are limited data on health care use among survivors of young adult cancers. We aimed to describe patterns of hospitalization among a cohort of long-term survivors compared with noncancer controls. METHODS: Persons diagnosed between the ages of 20 and 44 years with malignancies in Ontario, Canada, from 1992 to 1999, who lived at least 5 years recurrence free, were identified using the Ontario Cancer Registry and matched to noncancer controls. Hospitalizations were determined using hospital discharges, and rates were compared between survivors and controls...
August 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26054330/genetic-risk-of-subsequent-esophageal-cancer-in-lymphoma-and-breast-cancer-long-term-survival-patients-a-pilot-study
#16
E Boldrin, E Rumiato, M Fassan, M Rugge, M Cagol, D Marino, V Chiarion-Sileni, A Ruol, M Gusella, F Pasini, A Amadori, D Saggioro
The occurrence of a second primary esophageal carcinoma (EC) in long-term cancer survivors may represent a late effect of previous radio-chemotherapeutic treatment. To identify the genetic factors that could increase this risk, we analyzed nine variants within ERCC1, XPD, XRCC1 and XRCC3 DNA repair pathway genes, and GSTP1, TP53 and MDM2 genes in 61 patients who received radio-chemotherapy for a prior lymphoma or breast cancer; 29 of them had a second primary EC. This cohort consists of 22 esophageal squamous cell carcinoma (ESCC) and 7 esophageal adenocarcinoma (EADC) patients...
June 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/25979968/evolving-information-needs-among-colon-breast-and-prostate-cancer-survivors-results-from-a-longitudinal-mixed-effects-analysis
#17
Andy S L Tan, Rebekah H Nagler, Robert C Hornik, Angela DeMichele
BACKGROUND: This study describes how cancer survivors' information needs about recurrence, late effects, and family risks of cancer evolve over the course of their survivorship period. METHODS: Three annual surveys were conducted from 2006 to 2008 in a cohort of Pennsylvania cancer survivors diagnosed with colon, breast, or prostate cancer in 2005 (round 1, N = 2,013; round 2, N = 1,293; round 3, N = 1,128). Outcomes were information seeking about five survivorship topics...
July 2015: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/25956208/eurocourse-lessons-learned-from-and-for-population-based-cancer-registries-in-europe-and-their-programme-owners-improving-performance-by-research-programming-for-public-health-and-clinical-evaluation
#18
Jan Willem Coebergh, Corina van den Hurk, Stefano Rosso, Harry Comber, Hans Storm, Roberto Zanetti, Lidia Sacchetto, Maryska Janssen-Heijnen, Melissa Thong, Sabine Siesling, Janny van den Eijnden-van Raaij
UNLABELLED: Population-based cancer registries (CRs) in Europe have played a supportive, sometimes guiding, role in describing geographic variation of cancer epidemics and comparisons of oncological practice and preventive interventions since the 1950s for all types of cancer, separate and simultaneously. This paper deals with historical and longitudinal developments of the roughly 160 CRs and their programme owners (POs) that emerged since 1927 and accelerating since the late 70s especially in southern and continental Europe...
June 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/25779562/increased-incidence-of-fractures-in-recipients-of-hematopoietic-stem-cell-transplantation
#19
Xerxes N Pundole, Andrea G Barbo, Heather Lin, Richard E Champlin, Huifang Lu
PURPOSE: The number of long-term survivors after hematopoietic stem-cell transplantation (HSCT) for malignant and nonmalignant disorders is increasing, and late effects are gaining importance. Osteoporosis and fractures can worsen the quality of life of HSCT survivors, but the burden of the disease is unknown. PATIENTS AND METHODS: We conducted a retrospective study of patients older than age 18 years who underwent an HSCT at The University of Texas MD Anderson Cancer Center from January 1, 1997, to December 31, 2011, and were observed until December 31, 2013, to ascertain occurrence of fractures...
April 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25754634/minimizing-late-effects-for-patients-with-mediastinal-hodgkin-lymphoma-deep-inspiration-breath-hold-imrt-or-both
#20
Marianne C Aznar, Maja V Maraldo, Deborah A Schut, Michael Lundemann, N Patrik Brodin, Ivan R Vogelius, Anne K Berthelsen, Lena Specht, Peter M Petersen
PURPOSE: Hodgkin lymphoma (HL) survivors have an increased risk of cardiovascular disease (CD), lung cancer, and breast cancer. We investigated the risk for the development of CD and secondary lung, breast, and thyroid cancer after radiation therapy (RT) delivered with deep inspiration breath-hold (DIBH) compared with free-breathing (FB) using 3-dimensional conformal RT (3DCRT) and intensity modulated RT (IMRT). The aim of this study was to determine which treatment modality best reduced the combined risk of life-threatening late effects in patients with mediastinal HL...
May 1, 2015: International Journal of Radiation Oncology, Biology, Physics
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