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Cancer survivor cohort late effects

Elizabeth A M Feijen, Anna Font-Gonzalez, Elvira C van Dalen, Helena J H van der Pal, Raoul C Reulen, David L Winter, Claudia E Kuehni, Riccardo Haupt, Daniela Alessi, Julianne Byrne, Edit Bardi, Zsuzsanna Jakab, Desiree Grabow, Stanislaw Garwicz, Momcilo Jankovic, Gill A Levitt, Roderick Skinner, Lorna Zadravec Zaletel, Lars Hjorth, Wim J E Tissing, Florent de Vathaire, Mike M Hawkins, Leontien C M Kremer
BACKGROUND AND AIM: Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. METHODS: Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors...
2016: PloS One
Miranda M Fidler, Raoul C Reulen, David L Winter, Julie Kelly, Helen C Jenkinson, Rod Skinner, Clare Frobisher, Michael M Hawkins
OBJECTIVE:  To determine whether modern treatments for cancer are associated with a net increased or decreased risk of death from neoplastic and non-neoplastic causes among survivors of childhood cancer. DESIGN:  Population based cohort study. SETTING:  British Childhood Cancer Survivor Study. PARTICIPANTS:  Nationwide population based cohort of 34 489 five year survivors of childhood cancer with a diagnosis from 1940 to 2006 and followed up until 28 February 2014...
2016: BMJ: British Medical Journal
Sarah L Kerns, Leila Dorling, Laura Fachal, Søren Bentzen, Paul D P Pharoah, Daniel R Barnes, Antonio Gómez-Caamaño, Ana M Carballo, David P Dearnaley, Paula Peleteiro, Sarah L Gulliford, Emma Hall, Kyriaki Michailidou, Ángel Carracedo, Michael Sia, Richard Stock, Nelson N Stone, Matthew R Sydes, Jonathan P Tyrer, Shahana Ahmed, Matthew Parliament, Harry Ostrer, Barry S Rosenstein, Ana Vega, Neil G Burnet, Alison M Dunning, Gillian C Barnett, Catharine M L West
Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects in a minority limits doses prescribed to the majority of patients. Development of a test predicting risk of toxicity could benefit many cancer patients. We aimed to meta-analyze individual level data from four genome-wide association studies from prostate cancer radiotherapy cohorts including 1564 men to identify genetic markers of toxicity. Prospectively assessed two-year toxicity endpoints (urinary frequency, decreased urine stream, rectal bleeding, overall toxicity) and single nucleotide polymorphism (SNP) associations were tested using multivariable regression, adjusting for clinical and patient-related risk factors...
August 2016: EBioMedicine
Nickhill Bhakta, Qi Liu, Frederick Yeo, Malek Baassiri, Matthew J Ehrhardt, Deo K Srivastava, Monika L Metzger, Matthew J Krasin, Kirsten K Ness, Melissa M Hudson, Yutaka Yasui, Leslie L Robison
BACKGROUND: The magnitude of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkin's lymphoma is not known. Using medically ascertained data, we applied the cumulative burden metric to compare chronic cardiovascular health conditions in survivors of Hodgkin's lymphoma and general population controls. METHODS: For this study, participant data were obtained from two ongoing cohort studies at St Jude Children's Research Hospital: the St Jude Lifetime Cohort Study (SJLIFE) and the St Jude Long-term Follow-up Study (SJLTFU)...
September 2016: Lancet Oncology
Tara M Brinkman, Chenghong Li, Kathryn Vannatta, Jordan G Marchak, Jin-Shei Lai, Pinki K Prasad, Cara Kimberg, Stefanie Vuotto, Chongzhi Di, Deokumar Srivastava, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
PURPOSE: In the general population, psychological symptoms frequently co-occur; however, profiles of symptom comorbidities have not been examined among adolescent survivors of childhood cancer. PATIENTS AND METHODS: Parents of 3,893 5-year survivors of childhood cancer who were treated between 1970 and 1999 and who were assessed in adolescence (age 12 to 17 years) completed the Behavior Problems Index. Age- and sex-standardized z scores were calculated for symptom domains by using the Childhood Cancer Survivor Study sibling cohort...
October 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Diana Christine Maria Gunst, Peter Kaatsch, Lutz Goldbeck
PURPOSE: While knowledge about late psychosocial effects in pediatric cancer survivors is growing, investigation of positive changes, notably posttraumatic growth (PTG), is still lacking. Recent studies have not established any stable relationship between PTG and posttraumatic stress symptoms (PTSS), and it is still unclear which factors are associated with PTG in survivors of childhood cancer. The aims of this study were to give a quantitative description of PTG in long-term survivors of adolescent cancer and to investigate its association with psychological variables, especially the recalled amount of fear of death during treatment, as well as other cancer-related and demographic issues...
November 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ryne J DeBo, Cynthia J Lees, Greg O Dugan, David L Caudell, Kris T Michalson, David B Hanbury, Kylie Kavanagh, J Mark Cline, Thomas C Register
Heart disease is an increasingly recognized, serious late effect of radiation exposure, most notably among breast cancer and Hodgkin's disease survivors, as well as the Hiroshima and Nagasaki atomic bomb survivors. The purpose of this study was to evaluate the late effects of total-body irradiation (TBI) on cardiac morphology, function and selected circulating biomarkers in a well-established nonhuman primate model. For this study we used male rhesus macaques that were exposed to a single total-body dose of ionizing gamma radiation (6...
July 2016: Radiation Research
Irma W E M van Dijk, Helena J H van der Pal, Rob M van Os, Yvo B W E M Roos, Elske Sieswerda, Elvira C van Dalen, Cécile M Ronckers, Foppe Oldenburger, Flora E van Leeuwen, Huib N Caron, Caro C E Koning, Leontien C M Kremer
PURPOSE: Long-term childhood cancer survivors are at high risk of late adverse effects, including stroke. We aimed to determine the cumulative incidence of clinically validated symptomatic stroke (transient ischemic attack [TIA], cerebral infarction, and intracerebral hemorrhage [ICH]) and to quantify dose-effect relationships for cranial radiation therapy (CRT) and supradiaphragmatic radiation therapy (SDRT). METHODS AND MATERIALS: Our single-center study cohort included 1362 survivors of childhood cancer that were diagnosed between 1966 and 1996...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Peter Haubjerg Asdahl, Jeanette Falck Winther, Trine Gade Bonnesen, Sofie De Fine Licht, Thorgerdur Gudmundsdottir, Anna Sällfors Holmqvist, Nea Malila, Laufey Tryggvadottir, Finn Wesenberg, Jens Frederik Dahlerup, Jørgen Helge Olsen, Henrik Hasle
Survival after childhood cancer diagnosis has remarkably improved, but emerging evidence suggests that cancer-directed therapy may have adverse gastrointestinal late effects. We aimed to comprehensively assess the frequency of gastrointestinal and liver late effects among childhood cancer survivors and compare this frequency with the general population. Our population-based cohort study included all 1-year survivors of childhood and adolescent cancer in Denmark, Finland, Iceland, Norway and Sweden diagnosed from the 1940s and 1950s...
October 1, 2016: International Journal of Cancer. Journal International du Cancer
Mia Hashibe, Sarah Abdelaziz, Mohammed Al-Temimi, Alison Fraser, Kenneth M Boucher, Ken Smith, Yuan-Chin Amy Lee, Kerry Rowe, Braden Rowley, Micky Daurelle, Avery E Holton, James VanDerslice, Lorenzo Richiardi, Jay Bishoff, Will Lowrance, Antoinette Stroup
PURPOSE: Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. Our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. METHODS: We conducted a population-based cohort study of testicular cancer survivors, diagnosed 1991-2007, followed up for a median of 10 years. We identified 785 testicular cancer patients who survived ≥5 years and 3323 men free of cancer for the comparison group...
May 11, 2016: Journal of Cancer Survivorship: Research and Practice
Chad W M Ritenour, Kristy D Seidel, Wendy Leisenring, Ann C Mertens, Karen Wasilewski-Masker, Margarett Shnorhavorian, Charles A Sklar, John A Whitton, Marilyn Stovall, Louis S Constine, Gregory T Armstrong, Leslie L Robison, Lillian R Meacham
INTRODUCTION: With survival rates higher than 80%, the number of survivors from pediatric cancer continues to increase. Late effects resulting from cancer and cancer therapy are being characterized, but little information exists on sexual health for men who have survived childhood cancer. AIM: To assess erectile dysfunction (ED) in men who survived childhood and adolescent cancers and to identify potential risk factors for ED. METHODS: In total, 1,622 men and 271 eligible brothers in the Childhood Cancer Survivor Study cohort completed the Male Health Questionnaire, which provided information on sexual practices and sexual function...
June 2016: Journal of Sexual Medicine
Agnes Dumas, Claire Berger, Pascal Auquier, Gérard Michel, Brice Fresneau, Rodrigue Sètchéou Allodji, Nadia Haddy, Carole Rubino, Gilles Vassal, Dominique Valteau-Couanet, Sandrine Thouvenin-Doulet, Léonie Casagranda, Hélène Pacquement, Chiraz El-Fayech, Odile Oberlin, Catherine Guibout, Florent de Vathaire
BACKGROUND: Although survival from childhood cancer has increased, little is known on the long-term impact of treatment late effects on occupational attainment or work ability. METHODS: A total of 3512 five-year survivors treated before the age of 19 years in 10 French cancer centres between 1948 and 2000 were identified. Educational level, employment status and occupational class of survivors were assessed by a self-reported questionnaire. These outcome measures were compared with sex-age rates recorded in the French population, using indirect standardisation...
April 26, 2016: British Journal of Cancer
Andrew J Rosko, Matthew E Spector, Garrett R Griffin, Jeffrey M Vainshtein, Jae Lee, Carol R Bradford, Mark E P Prince, Jeffrey S Moyer, Francis P Worden, Avraham Eisbruch, Douglas B Chepeha
BACKGROUND: Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. METHODS: We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy...
August 2016: Head & Neck
Rachel Zhou, Angela Ng, Louis S Constine, Marilyn Stovall, Gregory T Armstrong, Joseph P Neglia, Debra L Friedman, Kara Kelly, Thomas J FitzGerald, David C Hodgson
PURPOSE: Survivors of pediatric Hodgkin lymphoma (HL) are recognized to have an increased risk of delayed adverse health outcomes related to radiation therapy (RT). However, the necessary latency required to observe these late effects means that the estimated risks apply to outdated treatments. We sought to compare the normal tissue dose received by children treated for HL and enrolled in the Childhood Cancer Survivor Study (CCSS) (diagnosed 1970-1986) with that of patients treated in recent Children's Oncology Group (COG) trials (enrolled 2002-2012)...
June 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kotaro Ozasa
The late effects of exposure to atomic bomb radiation on cancer occurrence have been evaluated by epidemiological studies on three cohorts: a cohort of atomic bomb survivors (Life Span Study; LSS), survivors exposed IN UTERO : , and children of atomic bomb survivors (F1). The risk of leukemia among the survivors increased remarkably in the early period after the bombings, especially among children. Increased risks of solid cancers have been evident since around 10 years after the bombings and are still present today...
August 2016: Journal of Radiation Research
Peter D Inskip, Alice J Sigurdson, Lene Veiga, Parveen Bhatti, Cécile Ronckers, Preetha Rajaraman, Houda Boukheris, Marilyn Stovall, Susan Smith, Sue Hammond, Tara O Henderson, Tanya C Watt, Ann C Mertens, Wendy Leisenring, Kayla Stratton, John Whitton, Sarah S Donaldson, Gregory T Armstrong, Leslie L Robison, Joseph P Neglia
OBJECTIVES: The majority of childhood cancer patients now achieve long-term survival, but the treatments that cured their malignancy often put them at risk of adverse health outcomes years later. New cancers are among the most serious of these late effects. The aims of this review are to compare and contrast radiation dose-response relationships for new solid cancers in a large cohort of childhood cancer survivors and to discuss interactions among treatment and host factors. METHODS: This review is based on previously published site-specific analyses for subsequent primary cancers of the brain, breast, thyroid gland, bone and soft tissue, salivary glands, and skin among 12,268 5-year childhood cancer survivors in the Childhood Cancer Survivor Study...
March 15, 2016: International Journal of Radiation Oncology, Biology, Physics
Paul C Nathan, Mohammad Agha, Jason D Pole, David Hodgson, Astrid Guttmann, Rinku Sutradhar, Mark L Greenberg
PURPOSE: The purpose of the present study is to determine predictors of attendance at a network of publicly funded specialized survivor clinics by a population-based cohort of adult survivors of childhood cancer. METHODS: We conducted a retrospective study linking data on eligible patients identified in a provincial pediatric cancer registry with health administrative databases to determine attendance at five specialized survivor clinics in the Canadian province of Ontario between 1999 and 2012...
August 2016: Journal of Cancer Survivorship: Research and Practice
E Brignardello, F Felicetti, A Castiglione, A Nervo, E Biasin, G Ciccone, F Fagioli, A Corrias
PURPOSE: To evaluate the prevalence of gonadal dysfunction and the associated risk factors in a cohort of male childhood cancer survivors (CCS). METHODS: Gonadal function was evaluated measuring FSH, LH, inhibin B and total testosterone levels. Patients with total testosterone <3 ng/dl were considered to have hypogonadism. Patients with FSH >10 UI/l and inhibin B <100 pg/ml were considered to have spermatogenesis damage (SD). To assess the impact of risk factors, we estimated crude and adjusted OR performing logistic regression models...
May 2016: Journal of Cancer Research and Clinical Oncology
Cak Fleming, K Viani, A J Murphy, T T Mosby, B Arora, J Schoeman, E J Ladas
BACKGROUND: Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking. AIMS: To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status. SETTINGS AND DESIGN: The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year...
April 2015: Indian Journal of Cancer
M Prasad, B Arora, G Chinnaswamy, T Vora, G Narula, S Banavali, P Kurkure
BACKGROUND: Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking. AIMS: To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status. SETTINGS AND DESIGN: The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year...
April 2015: Indian Journal of Cancer
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