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Cancer survivor cohort late effects

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https://www.readbyqxmd.com/read/29730199/sexual-function-in-a-nationwide-cohort-of-2260-testicular-cancer-survivors-after-17-years-follow-up
#1
Mikkel Bandak, Jakob Lauritsen, Christoffer Johansen, Michael Kreiberg, Julie Wang Skøtt, Mads Agerbaek, Niels V Holm, Gedske Daugaard
PURPOSE: Evidence on the long-term impact of testicular cancer (TC) treatment on sexual function is not clear. The aim was to estimate the effect of TC treatment on the risk of sexual dysfunction in long-term testicular cancer survivors. MATERIALS AND METHODS: We conducted a cross-sectional study of 2260 long-term TC survivors (median follow-up 17 years (IQR 12-24 years)) treated with orchiectomy alone (surveillance) (n=1098), bleomycin, etoposide, cisplatin (BEP) (BEP alone or BEP with post chemotherapy retroperitoneal surgery (n=788), abdominal radiotherapy (RT) (n=300), and more than one line of treatment (MTOL) (n=74)...
May 3, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29566148/co-administration-of-resveratrol-with-doxorubicin-in-young-mice-attenuates-detrimental-late-occurring-cardiovascular-changes
#2
Nobutoshi Matsumura, Beshay N Zordoky, Ian M Robertson, Shereen M Hamza, Nirmal Parajuli, Carrie-Lynn M Soltys, Donna L Beker, Marianne K Grant, Maria Razzoli, Alessandro Bartolomucci, Jason R B Dyck
AIMS: Doxorubicin (DOX) is among the most effective chemotherapies used in pediatric cancer patients. However, the clinical utility of DOX is offset by its well-known cardiotoxicity, which often does not appear until later in life. Since hypertension significantly increases the risk of late-onset heart failure in childhood cancer survivors, we investigated whether juvenile DOX exposure impairs the ability to adapt to angiotensin II (Ang II)-induced hypertension later in life as well as treatments that could prevent this...
March 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29553058/japanese-legacy-cohorts-the-life-span-study-atomic-bomb-survivor-cohort-and-survivors-offspring
#3
Kotaro Ozasa, Eric J Grant, Kazunori Kodama
Cohorts of atomic bomb survivors-including those exposed in utero-and children conceived after parental exposure were established to investigate late health effects of atomic bomb radiation and its transgenerational effects by the Atomic Bomb Casualty Commission (ABCC) in the 1950s. ABCC was reorganized to the Radiation Effects Research Foundation (RERF) in 1975, and all work has been continued at RERF. The Life Span Study, the cohort of survivors, consists of about 120,000 subjects and has been followed since 1950...
April 5, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29537134/fertility-perspectives-and-priorities-among-male-adolescents-and-young-adults-in-cancer-survivorship
#4
Leena Nahata, Nicole M Caltabellotta, Nicholas D Yeager, Vicky Lehmann, Stacy L Whiteside, Sarah H O'Brien, Gwendolyn P Quinn, Cynthia A Gerhardt
Infertility is a common and distressing late effect of cancer treatment among male survivors. Investigators examined desire for parenthood, prioritization of fertility compared to other life goals, and reports of fertility-related discussions among a cohort of male adolescent and young adult survivors. Eighty percent desired a biological child, yet only 31% ranked having a child among their "top 3" life goals. Only 40% reported fertility-related discussions with their health care providers in survivorship...
March 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29515973/cohort-profile-the-danish-testicular-cancer-late-treatment-effects-cohort-dateca-late
#5
Michael Kreiberg, Mikkel Bandak, Jakob Lauritsen, Julie Wang Skøtt, Nanna Borup Johansen, Mads Agerbaek, Niels Vilstrup Holm, Christoffer Johansen, Gedske Daugaard
The cohort was set up in order to analyze late effects in long-term testicular cancer survivors (TCS) and to contribute to the design of future follow-up programs addressing and potentially preventing late effects. Data for this cross-sectional study were collected between January 1, 2014, and December 31, 2016, among living Danish TCS and 60% agreed to participate in the cohort ( N  = 2,572). Mean time since testicular cancer (TC) diagnosis was 18 years (range 7-33) and mean age of participants was 53 years (range 25-95)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29502932/machine-learning-on-a-genome-wide-association-study-to-predict-late-genitourinary-toxicity-after-prostate-radiation-therapy
#6
Sangkyu Lee, Sarah Kerns, Harry Ostrer, Barry Rosenstein, Joseph O Deasy, Jung Hun Oh
PURPOSE: Late genitourinary (GU) toxicity after radiation therapy limits the quality of life of prostate cancer survivors; however, efforts to explain GU toxicity using patient and dose information have remained unsuccessful. We identified patients with a greater congenital GU toxicity risk by identifying and integrating patterns in genome-wide single nucleotide polymorphisms (SNPs). METHODS AND MATERIALS: We applied a preconditioned random forest regression method for predicting risk from the genome-wide data to combine the effects of multiple SNPs and overcome the statistical power limitations of single-SNP analysis...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29499085/left-hippocampal-dosimetry-correlates-with-visual-and-verbal-memory-outcomes-in-survivors-of-pediatric-brain-tumors
#7
Andrew H Zureick, Casey L Evans, Andrzej Niemierko, Julie A Grieco, Alexandra J Nichols, Barbara C Fullerton, Clayton B Hess, Claire P Goebel, Sara L Gallotto, Elizabeth A Weyman, Dillon E Gaudet, Jessica A Nartowicz, David H Ebb, Robin M Jones, Shannon M MacDonald, Nancy J Tarbell, Torunn I Yock, Margaret B Pulsifer
BACKGROUND: Radiotherapy (RT) in the pediatric brain tumor population causes late neurocognitive effects. In the current study, the authors investigated associations between clinical and dosimetric risk factors and memory outcomes in a cohort of patients treated with proton radiotherapy (PRT). METHODS: A total of 70 patients (median age at PRT, 12.1 years [range, 5.0-22.5 years]) who were treated with PRT were identified with baseline and follow-up evaluations of visual and verbal memory (Children's Memory Scale and the third edition of the Wechsler Memory Scale)...
May 15, 2018: Cancer
https://www.readbyqxmd.com/read/29497894/the-pancaresurfup-cohort-of-83-333-five-year-survivors-of-childhood-cancer-a-cohort-from-12-european-countries
#8
Desiree Grabow, Melanie Kaiser, Lars Hjorth, Julianne Byrne, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Chloe J Bright, Florent de Vathaire, Elizabeth A M Feijen, Stanislaw Garwicz, Oskar Hagberg, Riccardo Haupt, Mike M Hawkins, Zsuzsanna Jakab, Leontien C M Kremer, Claudia E Kuehni, Rahel Kuonen, Päivi Maria Lähteenmäki, Raoul C Reulen, Cécile M Ronckers, Carlotta Sacerdote, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, David L Winter, Jeanette Falck Winther, Lorna Zadravec Zaletel, Peter Kaatsch
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz...
March 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29468664/adverse-mental-health-outcomes-in-a-population-based-cohort-of-survivors-of-childhood-cancer
#9
Paul C Nathan, Alex Nachman, Rinku Sutradhar, Paul Kurdyak, Jason D Pole, Cindy Lau, Sumit Gupta
BACKGROUND: The elevated risk for physical late effects in childhood cancer survivors (CCS) is well documented, but their risk for mental health problems is less well described. METHODS: The authors assembled a cohort of all 5-year CCS who were diagnosed before age 18 years and treated in an Ontario pediatric cancer center between 1987 and 2008. Patients were matched to population controls and linked to health administration databases. The authors calculated rates of mental health care visits (family physician, psychiatrist, emergency department, hospitalization) and the risk for a severe mental health event (emergency department, hospitalization, suicide)...
May 1, 2018: Cancer
https://www.readbyqxmd.com/read/29439162/incidence-and-disease-burden-of-chemotherapy-induced-peripheral-neuropathy-in-a-population-based-cohort
#10
Arya Shah, E Matthew Hoffman, Michelle L Mauermann, Charles L Loprinzi, Anthony J Windebank, Christopher J Klein, Nathan P Staff
OBJECTIVE: To assess disease burden of chemotherapy-induced peripheral neuropathy (CIPN), which is a common dose-limiting side effect of neurotoxic chemotherapy. Late effects of CIPN may increase with improved cancer survival. METHODS: Olmsted County, Minnesota residents receiving neurotoxic chemotherapy were identified and CIPN was ascertained via text searches of polyneuropathy symptoms in the medical record. Clinical records were queried to collect data on baseline characteristics, risk factors, signs and symptoms of CIPN, medications, impairments and International Classification of Diseases, Ninth Revision (ICD-9) diagnostic codes for all subjects...
February 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29413284/brainstem-injury-in-pediatric-patients-with-posterior-fossa-tumors-treated-with-proton-beam-therapy-and-associated-dosimetric-factors
#11
Michelle S Gentile, Beow Y Yeap, Harald Paganetti, Claire P Goebel, Dillon E Gaudet, Sara L Gallotto, Elizabeth A Weyman, Michael L Morgan, Shannon M MacDonald, Drosoula Giantsoudi, Judith Adams, Nancy J Tarbell, Hanne Kooy, Torunn I Yock
PURPOSE: Proton radiation therapy is commonly used in young children with brain tumors for its potential to reduce late effects. However, some proton series report higher rates of brainstem injury (0%-16%) than most photon series (2.2%-8.6%). We report the incidence of brainstem injury and a risk factor analysis in pediatric patients with posterior fossa primary tumors treated with proton radiation therapy at our institution. METHODS AND MATERIALS: The study included 216 consecutive patients treated between 2000 and 2015...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29350454/patterns-of-internet-based-health-information-seeking-in-adult-survivors-of-childhood-cancer
#12
Mechelle D Claridy, Melissa M Hudson, Lee Caplan, Pauline A Mitby, Wendy Leisenring, Selina A Smith, Leslie L Robison, Ann C Mertens
BACKGROUND: To assess where, when, and why survivors of childhood cancer seek health information. PROCEDURE: Data from the Childhood Cancer Survivor Study (CCSS) cohort (n = 1386) and Health Information National Trends Survey (n = 2385) were analyzed to determine the health information seeking strategies of childhood cancer survivors. Descriptive frequencies, χ2 analyses, t-tests, and multivariable logistic regression models were used. RESULTS: To seek health-related information for themselves, 54% (n = 742) of the childhood survivors reported using the Internet in the past 12 months, compared to 45% of the general population (adjusted OR: 2...
May 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29273944/health-status-of-polish-children-and-adolescents-after-cancer-treatment
#13
Maryna Krawczuk-Rybak, Anna Panasiuk, Teresa Stachowicz-Stencel, Małgorzata Zubowska, Jolanta Skalska-Sadowska, Dorota Sęga-Pondel, Aneta Czajńska-Deptuła, Dorota Sławińska, Wanda Badowska, Elżbieta Kamieńska, Aneta Pobudejska-Pieniążek, Maria Wieczorek
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
March 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29196836/modifiable-and-non-modifiable-risk-factors-for-preterm-delivery-among-adolescent-and-young-adult-cancer-survivors
#14
Chelsea Anderson, Andrew B Smitherman, Stephanie M Engel, Hazel B Nichols
PURPOSE: A cancer diagnosis in adolescence and young adulthood (AYA, ages 15-39) may affect future pregnancy outcomes. Previous studies have reported an increased risk of preterm delivery (< 37 weeks of gestation) after maternal cancer treatment. In this analysis, we evaluated whether non-cancer characteristics modify the association between an AYA cancer history and preterm birth. METHODS: North Carolina Central Cancer Registry records (2000-2013) were linked to state birth certificate files (2000-2014) to identify births to AYA cancer survivors (n = 1,980)...
February 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29185125/measuring-childhood-cancer-late-effects-evidence-of-a-healthy-survivor-effect
#15
Peter Haubjerg Asdahl, Rohit Priyadarshi Ojha, Jeanette Falck Winther, Anna Sällfors Holmqvist, Sofie de Fine Licht, Thorgerdur Gudmundsdottir, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Klaus Kaae Andersen, Henrik Hasle
INTRODUCTION: Given considerable focus on health outcomes among childhood cancer survivors, we aimed to explore whether survivor bias is apparent during long-term follow-up of childhood cancer survivors. METHODS: We identified all 1-year survivors of cancer diagnosed before 20 years of age in Denmark, Finland, Iceland, and Sweden. From the general population, we randomly sampled a comparison cohort. Study individuals were followed for hospitalizations for diseases of the gastroenterological tract, endocrine system, cardiovascular system, or urinary tract from the start of the cancer registries to 2010...
December 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28929821/effects-of-a-translational-community-based-multimodal-exercise-program-on-quality-of-life-and-the-influence-of-start-delay-on-physical-function-and-quality-of-life-in-breast-cancer-survivors-a-pilot-study
#16
Michael Paul Foley, Scott Michael Hasson, Eydie Kendall
The purpose of this investigation was 2-fold: (1) to investigate the effects of a translational 12-week community-based multimodal exercise program on quality of life (QoL) in breast cancer survivors (BCS) and (2) to examine the influence of a start delay on physical function and QoL in BCS. Fifty-two female BCS completed a 12-week program consisting of 90-minute supervised exercise sessions at a frequency of 2 supervised sessions per week. Exercise sessions consisted of three 30-minute components: (1) aerobic conditioning, (2) resistance exercise training, and (3) balance and flexibility training...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28851949/hypertension-susceptibility-loci-are-associated-with-anthracycline-related-cardiotoxicity-in-long-term-childhood-cancer-survivors
#17
Michelle A T Hildebrandt, Monica Reyes, Xifeng Wu, Xia Pu, Kara A Thompson, Jianzhong Ma, Andrew P Landstrom, Alanna C Morrison, Joann L Ater
Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predictors for development of late cardiotoxicity. Therefore, we determined the association between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of long-term childhood cancer survivors (N = 108) who received anthracyclines and were screened for cardiac function via echocardiograms...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844157/validation-of-genetic-predictors-of-late-radiation-induced-morbidity-in-prostate-cancer-patients
#18
Line M H Schack, Stine E Petersen, Steffen Nielsen, Lilly Lundby, Morten Høyer, Lise Bentzen, Jens Overgaard, Christian N Andreassen, Jan Alsner
INTRODUCTION: Normal tissue morbidity sets the dose limit for radiotherapy (RT) in cancer treatment and has importance for quality of life for cancer survivors. A previous study of prostate cancer patients treated with RT generated clinical data for radiation-induced morbidity measured by anorectal physiological methods and validated questionnaires. Other studies have identified genetic predictors associated with late radiation-induced morbidity outcome. We have expanded biobank material aiming to validate single nucleotide polymorphisms (SNPs) and a gene expression classifier with endpoints on patient-reported outcomes and biomechanical properties of the anorectum from our cohort matching originally published endpoints...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28843055/exercise-right-heart-catheterization-for-pulmonary-hypertension-identified-on-screening-echocardiography-in-adult-survivors-of-childhood-cancer-a-report-from-the-st-jude-lifetime-cohort
#19
Gregory T Armstrong, James J Tolle, Robert Piana, Aimee Santucci, James Leathers, Kirsten K Ness, Daniel A Mulrooney, Daniel M Green, Vijaya M Joshi, Leslie L Robison, Melissa M Hudson, Daniel Lenihan
Pulmonary hypertension, determined noninvasively by tricuspid regurgitant jet velocity on Doppler echocardiography, was previously identified in 25% of long-term survivors who received chest-directed radiotherapy. To validate noninvasively defined pulmonary hypertension, survivors (mean age 48 years), exposed to chest radiotherapy, underwent right heart catheterization with planned cardiopulmonary exercise testing during catheterization. Eight participants had an elevated mean pulmonary artery pressure at rest (≥25 mm Hg) or with subsequent exercise (>30 mm Hg), evidence of hemodynamically confirmed pulmonary hypertension by right heart catheterization...
January 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28774277/novel-approaches-to-the-prediction-diagnosis-and-treatment-of-cardiac-late-effects-in-survivors-of-childhood-cancer-a-multi-centre-observational-study
#20
Amy Skitch, Seema Mital, Luc Mertens, Peter Liu, Paul Kantor, Lars Grosse-Wortmann, Cedric Manlhiot, Mark Greenberg, Paul C Nathan
BACKGROUND: Anthracycline-induced cardiac toxicity is a cause of significant morbidity and early mortality in survivors of childhood cancer. Current strategies for predicting which children are at greatest risk for toxicity are imperfect and diagnosis of cardiac injury is usually made relatively late in the natural history of the disease. This study aims to identify genomic, biomarker and imaging parameters that can be used as predictors of risk or aid in the early diagnosis of cardiotoxicity...
August 3, 2017: BMC Cancer
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