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Cancer survivor cohort late effects

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https://www.readbyqxmd.com/read/29273944/health-status-of-polish-children-and-adolescents-after-cancer-treatment
#1
Krawczuk-Rybak Maryna, Panasiuk Anna, Stachowicz-Stencel Teresa, Zubowska Małgorzata, Skalska-Sadowska Jolanta, Sęga-Pondel Dorota, Czajńska-Deptuła Aneta, Sławińska Dorota, Badowska Wanda, Kamieńska Elżbieta, Pobudejska-Pieniążek Aneta, Wieczorek Maria
In the last 40 years, considerable progress was made in the treatment of childhood cancer. Nearly 80% of children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. This is the first Polish study analyzing the general health status and epidemiology of organ late effects in the cohort of Polish childhood and adolescent cancer survivors monitored by doctors and registered in the on-line national database for late effects (N = 1761). This tool collects information on previous therapy and current health status (medical history, physical examination, laboratory tests) of cancer survivors...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29196836/modifiable-and-non-modifiable-risk-factors-for-preterm-delivery-among-adolescent-and-young-adult-cancer-survivors
#2
Chelsea Anderson, Andrew B Smitherman, Stephanie M Engel, Hazel B Nichols
PURPOSE: A cancer diagnosis in adolescence and young adulthood (AYA, ages 15-39) may affect future pregnancy outcomes. Previous studies have reported an increased risk of preterm delivery (< 37 weeks of gestation) after maternal cancer treatment. In this analysis, we evaluated whether non-cancer characteristics modify the association between an AYA cancer history and preterm birth. METHODS: North Carolina Central Cancer Registry records (2000-2013) were linked to state birth certificate files (2000-2014) to identify births to AYA cancer survivors (n = 1,980)...
December 1, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29185125/measuring-childhood-cancer-late-effects-evidence-of-a-healthy-survivor-effect
#3
Peter Haubjerg Asdahl, Rohit Priyadarshi Ojha, Jeanette Falck Winther, Anna Sällfors Holmqvist, Sofie de Fine Licht, Thorgerdur Gudmundsdottir, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Klaus Kaae Andersen, Henrik Hasle
INTRODUCTION: Given considerable focus on health outcomes among childhood cancer survivors, we aimed to explore whether survivor bias is apparent during long-term follow-up of childhood cancer survivors. METHODS: We identified all 1-year survivors of cancer diagnosed before 20 years of age in Denmark, Finland, Iceland, and Sweden. From the general population, we randomly sampled a comparison cohort. Study individuals were followed for hospitalizations for diseases of the gastroenterological tract, endocrine system, cardiovascular system, or urinary tract from the start of the cancer registries to 2010...
November 28, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28929821/effects-of-a-translational-community-based-multimodal-exercise-program-on-quality-of-life-and-the-influence-of-start-delay-on-physical-function-and-quality-of-life-in-breast-cancer-survivors-a-pilot-study
#4
Michael Paul Foley, Scott Michael Hasson, Eydie Kendall
The purpose of this investigation was 2-fold: (1) to investigate the effects of a translational 12-week community-based multimodal exercise program on quality of life (QoL) in breast cancer survivors (BCS) and (2) to examine the influence of a start delay on physical function and QoL in BCS. Fifty-two female BCS completed a 12-week program consisting of 90-minute supervised exercise sessions at a frequency of 2 supervised sessions per week. Exercise sessions consisted of three 30-minute components: (1) aerobic conditioning, (2) resistance exercise training, and (3) balance and flexibility training...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28851949/hypertension-susceptibility-loci-are-associated-with-anthracycline-related-cardiotoxicity-in-long-term-childhood-cancer-survivors
#5
Michelle A T Hildebrandt, Monica Reyes, Xifeng Wu, Xia Pu, Kara A Thompson, Jianzhong Ma, Andrew P Landstrom, Alanna C Morrison, Joann L Ater
Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predictors for development of late cardiotoxicity. Therefore, we determined the association between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of long-term childhood cancer survivors (N = 108) who received anthracyclines and were screened for cardiac function via echocardiograms...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844157/validation-of-genetic-predictors-of-late-radiation-induced-morbidity-in-prostate-cancer-patients
#6
Line M H Schack, Stine E Petersen, Steffen Nielsen, Lilly Lundby, Morten Høyer, Lise Bentzen, Jens Overgaard, Christian N Andreassen, Jan Alsner
INTRODUCTION: Normal tissue morbidity sets the dose limit for radiotherapy (RT) in cancer treatment and has importance for quality of life for cancer survivors. A previous study of prostate cancer patients treated with RT generated clinical data for radiation-induced morbidity measured by anorectal physiological methods and validated questionnaires. Other studies have identified genetic predictors associated with late radiation-induced morbidity outcome. We have expanded biobank material aiming to validate single nucleotide polymorphisms (SNPs) and a gene expression classifier with endpoints on patient-reported outcomes and biomechanical properties of the anorectum from our cohort matching originally published endpoints...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28843055/exercise-right-heart-catheterization-for-pulmonary-hypertension-identified-on-screening-echocardiography-in-adult-survivors-of-childhood-cancer-a-report-from-the-st-jude-lifetime-cohort
#7
Gregory T Armstrong, James J Tolle, Robert Piana, Aimee Santucci, James Leathers, Kirsten K Ness, Daniel A Mulrooney, Daniel M Green, Vijaya M Joshi, Leslie L Robison, Melissa M Hudson, Daniel Lenihan
Pulmonary hypertension, determined noninvasively by tricuspid regurgitant jet velocity on Doppler echocardiography, was previously identified in 25% of long-term survivors who received chest-directed radiotherapy. To validate noninvasively defined pulmonary hypertension, survivors (mean age 48 years), exposed to chest radiotherapy, underwent right heart catheterization with planned cardiopulmonary exercise testing during catheterization. Eight participants had an elevated mean pulmonary artery pressure at rest (≥25 mm Hg) or with subsequent exercise (>30 mm Hg), evidence of hemodynamically confirmed pulmonary hypertension by right heart catheterization...
January 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28774277/novel-approaches-to-the-prediction-diagnosis-and-treatment-of-cardiac-late-effects-in-survivors-of-childhood-cancer-a-multi-centre-observational-study
#8
Amy Skitch, Seema Mital, Luc Mertens, Peter Liu, Paul Kantor, Lars Grosse-Wortmann, Cedric Manlhiot, Mark Greenberg, Paul C Nathan
BACKGROUND: Anthracycline-induced cardiac toxicity is a cause of significant morbidity and early mortality in survivors of childhood cancer. Current strategies for predicting which children are at greatest risk for toxicity are imperfect and diagnosis of cardiac injury is usually made relatively late in the natural history of the disease. This study aims to identify genomic, biomarker and imaging parameters that can be used as predictors of risk or aid in the early diagnosis of cardiotoxicity...
August 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28735719/treatment-with-chemotherapy-and-cognitive-functioning-in-older-adult-cancer-survivors
#9
Ruth T Morin, Elizabeth Midlarsky
OBJECTIVE: To investigate whether treatment of cancer with chemotherapy, as compared with surgery and radiation, differentially affects cognitive functioning in older adults. DESIGN: Latent class growth analysis approach. SETTING: Health and Retirement Study. PARTICIPANTS: Older adults (N=403) with a new diagnosis of cancer who were still alive 4 years after their diagnosis. INTERVENTIONS: Not applicable...
July 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28486495/long-term-inpatient-disease-burden-in-the-adult-life-after-childhood-cancer-in-scandinavia-aliccs-study-a-cohort-study-of-21-297-childhood-cancer-survivors
#10
Sofie de Fine Licht, Kathrine Rugbjerg, Thorgerdur Gudmundsdottir, Trine G Bonnesen, Peter Haubjerg Asdahl, Anna Sällfors Holmqvist, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Finn Wesenberg, Henrik Hasle, Jeanette F Winther, Jørgen H Olsen
BACKGROUND: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. METHODS AND FINDINGS: From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943-2008 in Denmark, 1971-2008 in Finland, 1955-2008 in Iceland, and 1958-2008 in Sweden...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28426850/second-primary-malignant-neoplasms-and-survival-in-adolescent-and-young-adult-cancer-survivors
#11
Theresa H M Keegan, Archie Bleyer, Aaron S Rosenberg, Qian Li, Melanie Goldfarb
Importance: Although the increased incidence of second primary malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared survival after an SPM to survival of the same cancer occurring as first primary malignant neoplasm (PM) by age. Objective: To assess the survival impact of SPMs in adolescents and young adults (AYAs) (15-39 years) compared with that of pediatric (<15 years) and older adult (≥40 years) patients with the same SPMs...
November 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28344563/a-review-of-demographic-medical-and-treatment-variables-associated-with-health-related-quality-of-life-hrqol-in-survivors-of-hematopoietic-stem-cell-hsct-and-bone-marrow-transplantation-bmt-during-childhood
#12
REVIEW
Trude Reinfjell, Marta Tremolada, Lonnie K Zeltzer
Hematopoietic stem cell transplantation (HSCT) is a standard treatment after disease relapse and failure of conventional treatments for cancer in childhood or as a first line treatment for some high-risk cancers. Since hematopoietic stem cells can be found in the marrow (previously called a bone marrow transplantation) or periphery, we refer to HSCT as inclusive of HSCT regardless of the origin of the stem cells. HSCT is associated with adverse side effects, prolonged hospitalization, and isolation. Previous studies have shown that survivors of HSCT are at particularly high risk for developing late effects and medical complications, and thus, in addition to survival, quality of life in survivors of HSCT is an important outcome...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28333999/validation-of-questionnaire-reported-hearing-with-medical-records-a-report-from-the-swiss-childhood-cancer-survivor-study
#13
Annette Weiss, Grit Sommer, Rahel Kuonen, Katrin Scheinemann, Michael Grotzer, Martin Kompis, Claudia E Kuehni
BACKGROUND: Hearing loss is a potential late effect after childhood cancer. Questionnaires are often used to assess hearing in large cohorts of childhood cancer survivors and it is important to know if they can provide valid measures of hearing loss. We therefore assessed agreement and validity of questionnaire-reported hearing in childhood cancer survivors using medical records as reference. PROCEDURE: In this validation study, we studied 361 survivors of childhood cancer from the Swiss Childhood Cancer Survivor Study (SCCSS) who had been diagnosed after 1989 and had been exposed to ototoxic cancer treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28270931/design-and-methods-of-the-pan-canadian-applying-biomarkers-to-minimize-long-term-effects-of-childhood-adolescent-cancer-treatment-able-nephrotoxicity-study-a-prospective-observational-cohort-study
#14
Kelly R McMahon, Shahrad Rod Rassekh, Kirk R Schultz, Maury Pinsk, Tom Blydt-Hansen, Cherry Mammen, Ross T Tsuyuki, Prasad Devarajan, Geoff D E Cuvelier, Lesley G Mitchell, Sylvain Baruchel, Ana Palijan, Bruce C Carleton, Colin J D Ross, Michael Zappitelli
BACKGROUND: Childhood cancer survivors experience adverse drug events leading to lifelong health issues. The Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) team was established to validate and apply biomarkers of cancer treatment effects, with a goal of identifying children at high risk of developing cancer treatment complications associated with thrombosis, graft-versus-host disease, hearing loss, and kidney damage. Cisplatin is a chemotherapy well known to cause acute and chronic nephrotoxicity...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28205419/prevalence-of-cardiovascular-late-sequelae-in-long-term-survivors-of-childhood-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Peter Scholz-Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig
BACKGROUND: Cardiovascular diseases are well-known late effects of childhood cancer and research on these late effects is a highly important emerging field. We conducted a systematic review with a meta-analysis to give an overview of the current evidence and the prevalence of late cardiovascular events. PROCEDURE: We included publications in which the study populations were children and adolescents who survived cancer. Outcome was defined as all cardiovascular clinical and subclinical endpoints or diagnoses appearing at least one year after cancer diagnosis...
July 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28158314/identifying-radiation-induced-survivorship-syndromes-affecting-bowel-health-in-a-cohort-of-gynecological-cancer-survivors
#16
Gunnar Steineck, Viktor Skokic, Fei Sjöberg, Cecilia Bull, Eleftheria Alevronta, Gail Dunberger, Karin Bergmark, Ulrica Wilderäng, Jung Hun Oh, Joseph O Deasy, Rebecka Jörnsten
BACKGROUND: During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. METHODS: Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health...
2017: PloS One
https://www.readbyqxmd.com/read/28098955/the-impact-of-childhood-cancer-perceptions-of-adult-survivors
#17
Victoria W Willard, James L Klosky, Chenghong Li, Deo Kumar Srivastava, Tara M Brinkman, Leslie L Robison, Melissa M Hudson, Sean Phipps
BACKGROUND: The objective of this study was to describe perceptions and associated risk factors of the impact of cancer on functional outcomes, including social relationships, exercise, finances, and religion, among adult survivors of childhood cancer. METHODS: Evaluable participants included 3001 adult survivors (mean age, 32.5 years; range, 18.3-63.8 years; 24.1 years from diagnosis; 50.8% male; 84.9% Caucasian) who were enrolled in the St. Jude Lifetime Cohort study...
May 1, 2017: Cancer
https://www.readbyqxmd.com/read/27966803/yield-of-screening-echocardiograms-during-pediatric-follow-up-in-survivors-treated-with-anthracyclines-and-cardiotoxic-radiation
#18
Michael B Spewak, Rebecca S Williamson, Ann C Mertens, William L Border, Lillian R Meacham, Karen J Wasilewski-Masker
BACKGROUND: Guidelines published by the Children's Oncology Group recommend screening echocardiograms for childhood cancer survivors exposed to anthracyclines and/or cardiotoxic radiation. This study aims to assess risk factors for cardiac late effects while evaluating the overall yield of screening echocardiograms. PROCEDURE: Demographics, exposures, and echocardiogram results were abstracted from the medical records of survivors diagnosed at ≤ 21 years old and ≥ 2 years off therapy who were exposed to anthracyclines and/or potentially cardiotoxic radiotherapy...
June 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27965842/a-head-and-neck-cancer-intervention-for-use-in-survivorship-clinics-a-protocol-for-a-feasibility-study
#19
Talya Salz, Mary S McCabe, Kevin C Oeffinger, Stacie Corcoran, Andrew J Vickers, Andrew L Salner, Ellen Dornelas, Rebecca Schnall, Nirupa J Raghunathan, Elizabeth Fortier, Shrujal S Baxi
BACKGROUND: Head and neck cancer survivors commonly experience severe long-term toxicities, late-occurring symptoms, and significant risks of the second primary malignancy and comorbid illnesses. With multiple simultaneous health issues, these complex cancer survivors often do not receive comprehensive health care that addresses their needs. A tool is needed to streamline and standardize comprehensive care for this cohort. METHODS/DESIGN: We designed the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR) to address health care challenges for head and neck cancer survivors...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27919332/effects-of-ionizing-radiation-on-the-mammalian-brain
#20
REVIEW
Daniela Hladik, Soile Tapio
Epidemiological studies on the atomic-bomb survivors, cancer survivors and occupational cohorts provide strong evidence for multifaceted damage to brain after ionizing radiation. Radiation-induced late effects may manifest as brain tumors or cognitive impairment. Decreased neurogenesis and differentiation, alteration in neural structure and synaptic plasticity as well as increased oxidative stress and inflammation are suggested to contribute to adverse effects in the brain. In addition to neural stems cells, several brain-specific mature cell types including endothelial and glial cells are negatively affected by ionizing radiation...
October 2016: Mutation Research
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