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https://www.readbyqxmd.com/read/29555990/adult-height-is-associated-with-increased-risk-of-ovarian-cancer-a-mendelian-randomisation-study
#1
Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul D P Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Audrey Y Jung, Kirsten B Moysich, Kunle Odunsi, Marc T Goodman, Lynne R Wilkens, Pamela J Thompson, Yurii B Shvetsov, Thilo Dörk, Tjoung-Won Park-Simon, Peter Hillemanns, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa M Pelttari, Arto Leminen, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Joseph L Kelley, Florian Heitz, Andreas du Bois, Philipp Harter, Ira Schwaab, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Bobbie J Rimel, Susanne K Kjær, Estrid Høgdall, Allan Jensen, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Stacey J Winham, Graham G Giles, Fiona Bruinsma, Roger L Milne, Melissa C Southey, Michelle A T Hildebrandt, Xifeng Wu, Karen H Lu, Dong Liang, Douglas A Levine, Maria Bisogna, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elisa V Bandera, Sara H Olson, Helga B Salvesen, Liv Cecilie Vestrheim Thomsen, Reidun K Kopperud, Line Bjorge, Lambertus A Kiemeney, Leon F A G Massuger, Tanja Pejovic, Amanda Bruegl, Linda S Cook, Nhu D Le, Kenneth D Swenerton, Angela Brooks-Wilson, Linda E Kelemen, Jan Lubiński, Tomasz Huzarski, Jacek Gronwald, Janusz Menkiszak, Nicolas Wentzensen, Louise Brinton, Hannah Yang, Jolanta Lissowska, Claus K Høgdall, Lene Lundvall, Honglin Song, Jonathan P Tyrer, Ian Campbell, Diana Eccles, James Paul, Rosalind Glasspool, Nadeem Siddiqui, Alice S Whittemore, Weiva Sieh, Valerie McGuire, Joseph H Rothstein, Steven A Narod, Catherine Phelan, Harvey A Risch, John R McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Anna H Wu, Malcolm C Pike, Chiu-Chen Tseng, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Iwona K Rzepecka, Penelope M Webb
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms...
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29547330/gw170817-implications-for-the-stochastic-gravitational-wave-background-from-compact-binary-coalescences
#2
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, D V Atallah, P Aufmuth, C Aulbert, K AultONeal, C Austin, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, K Barkett, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, M Bawaj, J C Bayley, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, J J Bero, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, S Biscoveanu, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, E Bonilla, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, K Bossie, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, P Cerdá-Durán, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chase, E Chassande-Mottin, D Chatterjee, B D Cheeseboro, H Y Chen, X Chen, Y Chen, H-P Cheng, H Chia, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, P Clearwater, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, D Cohen, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero-Carrión, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, G Dálya, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, N Demos, T Denker, T Dent, R De Pietri, V Dergachev, R De Rosa, R T DeRosa, C De Rossi, R DeSalvo, O de Varona, J Devenson, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, C Dreissigacker, J C Driggers, Z Du, M Ducrot, P Dupej, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, C Fee, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, D Finstad, I Fiori, D Fiorucci, M Fishbach, R P Fisher, M Fitz-Axen, R Flaminio, M Fletcher, H Fong, J A Font, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, C Garcia-Quiros, F Garufi, B Gateley, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, B Goncharov, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, E M Gretarsson, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, O Halim, B R Hall, E D Hall, E Z Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, M Heurs, S Hild, T Hinderer, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, A Hreibi, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, S Karki, K S Karvinen, M Kasprzack, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, K Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, M Kinley-Hanlon, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, S D Linker, T B Littenberg, J Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, R Macas, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, K Mason, E Massera, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, L McNeill, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, B B Miller, J Miller, M Millhouse, M C Milovich-Goff, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, D Moffa, A Moggi, K Mogushi, M Mohan, S R P Mohapatra, M Montani, C J Moore, D Moraru, G Moreno, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A Muñiz, M Muratore, P G Murray, K Napier, I Nardecchia, L Naticchioni, R K Nayak, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, L Nevin, J M Newport, G Newton, K K Y Ng, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, C North, L K Nuttall, J Oberling, G D O'Dea, G H Ogin, J J Oh, S H Oh, F Ohme, M A Okada, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, S Ossokine, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, Howard Pan, Huang-Wei Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, A Parida, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patil, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pirello, M Pitkin, M Poe, R Poggiani, P Popolizio, E K Porter, A Post, J Powell, J Prasad, J W W Pratt, G Pratten, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, A Ramos-Buades, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, W Ren, S D Reyes, F Ricci, P M Ricker, S Rieger, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, J D Romano, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, G Rutins, K Ryan, S Sachdev, T Sadecki, L Sadeghian, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, L E Sanchez, N Sanchis-Gual, V Sandberg, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, M Scheel, J Scheuer, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, M B Shaner, L Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, L P Singer, A Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, S Somala, E J Son, J A Sonnenberg, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, K Staats, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, S P Stevenson, R Stone, D J Stops, K A Strain, G Stratta, S E Strigin, A Strunk, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, J Suresh, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, S C Tait, C Talbot, D Talukder, D B Tanner, M Tápai, A Taracchini, J D Tasson, J A Taylor, R Taylor, S V Tewari, T Theeg, F Thies, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, A Torres-Forné, C I Torrie, D Töyrä, F Travasso, G Traylor, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, L Tsukada, D Tsuna, D Tuyenbayev, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, E K Wessel, P Weßels, J Westerweck, T Westphal, K Wette, J T Whelan, B F Whiting, C Whittle, D Wilken, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Wofford, K W K Wong, J Worden, J L Wright, D S Wu, D M Wysocki, S Xiao, H Yamamoto, C C Yancey, L Yang, M J Yap, M Yazback, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, M E Zucker, J Zweizig
The LIGO Scientific and Virgo Collaborations have announced the event GW170817, the first detection of gravitational waves from the coalescence of two neutron stars. The merger rate of binary neutron stars estimated from this event suggests that distant, unresolvable binary neutron stars create a significant astrophysical stochastic gravitational-wave background. The binary neutron star component will add to the contribution from binary black holes, increasing the amplitude of the total astrophysical background relative to previous expectations...
March 2, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29453291/lsd1-inhibition-exerts-its-antileukemic-effect-by-recommissioning-pu-1-and-c-ebp%C3%AE-dependent-enhancers-in-aml
#3
Monica Cusan, Sheng F Cai, Helai P Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D Witkin, Kimberly N Smitheman, Daniel G Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G Kruger, Ross L Levine, Hugh Y Rienhoff, Richard P Koche, Scott A Armstrong
Epigenetic regulators are recurrently mutated and aberrantly expressed in acute myeloid leukemia (AML). Targeted therapies designed to inhibit these chromatin-modifying enzymes, such as the histone demethylase lysine-specific demethylase 1 (LSD1) and the histone methyltransferase DOT1L, have been developed as novel treatment modalities for these often refractory diseases. A common feature of many of these targeted agents is their ability to induce myeloid differentiation, suggesting that multiple paths toward a myeloid gene expression program can be engaged to relieve the differentiation blockade that is uniformly seen in AML...
April 12, 2018: Blood
https://www.readbyqxmd.com/read/29400511/first-search-for-nontensorial-gravitational-waves-from-known-pulsars
#4
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, P Aufmuth, C Aulbert, K AultONeal, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, M Bawaj, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, N M Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, D Chatterjee, B D Cheeseboro, H Y Chen, Y Chen, H-P Cheng, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, J Devenson, R C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, J Duncan, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, H Fong, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, M Gabel, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, F Garufi, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, J Henry, A W Heptonstall, M Heurs, S Hild, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, D R Ingram, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, S Kandhasamy, G Kang, J B Kanner, S Karki, K S Karvinen, M Kasprzack, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, A Libson, T B Littenberg, J Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, D V Martynov, K Mason, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, F Mezzani, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, A Miller, B B Miller, J Miller, M Millhouse, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, A Moggi, M Mohan, S R P Mohapatra, M Montani, B C Moore, C J Moore, D Moraru, G Moreno, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A M Muniz, P G Murray, K Napier, I Nardecchia, L Naticchioni, R K Nayak, G Nelemans, T J N Nelson, M Neri, M Nery, A Neunzert, J M Newport, G Newton, K K Y Ng, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, M E N Normandin, L K Nuttall, J Oberling, E Ochsner, E Oelker, G H Ogin, J J Oh, S H Oh, F Ohme, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, H Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, H R Paris, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pitkin, R Poggiani, P Popolizio, E K Porter, A Post, J Powell, J Prasad, J W W Pratt, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, R Prix, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, J Qin, S Qiu, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, M Rakhmanov, K E Ramirez, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, H Rew, S D Reyes, F Ricci, P M Ricker, S Rieger, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, K Ryan, S Sachdev, T Sadecki, L Sadeghian, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, V Sandberg, B Sandeen, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, J Scheuer, E Schmidt, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, L Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, A Singer, L P Singer, A Singh, R Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, E J Son, J A Sonnenberg, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B C Stephens, R Stone, K A Strain, G Stratta, S E Strigin, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, D Talukder, D B Tanner, M Tápai, A Taracchini, J A Taylor, R Taylor, T Theeg, E G Thomas, M Thomas, P Thomas, K A Thorne, K S Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, C I Torrie, D Töyrä, F Travasso, G Traylor, D Trifirò, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, D Tuyenbayev, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, M Vallisneri, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, D V Voss, W D Vousden, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, M Wang, Y-F Wang, Y Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, E K Wessel, P Weßels, T Westphal, K Wette, J T Whelan, B F Whiting, C Whittle, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Wofford, K W K Wong, J Worden, J L Wright, D S Wu, G Wu, W Yam, H Yamamoto, C C Yancey, M J Yap, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, M E Zucker, J Zweizig, S Buchner, I Cognard, A Corongiu, P C C Freire, L Guillemot, G B Hobbs, M Kerr, A G Lyne, A Possenti, A Ridolfi, R M Shannon, B W Stappers, P Weltevrede
We present results from the first directed search for nontensorial gravitational waves. While general relativity allows for tensorial (plus and cross) modes only, a generic metric theory may, in principle, predict waves with up to six different polarizations. This analysis is sensitive to continuous signals of scalar, vector, or tensor polarizations, and does not rely on any specific theory of gravity. After searching data from the first observation run of the advanced LIGO detectors for signals at twice the rotational frequency of 200 known pulsars, we find no evidence of gravitational waves of any polarization...
January 19, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29395057/jak1-integrates-cytokine-sensing-to-regulate-hematopoietic-stem-cell-function-and-stress-hematopoiesis
#5
Maria Kleppe, Matthew H Spitzer, Sheng Li, Corinne E Hill, Lauren Dong, Efthymia Papalexi, Sofie De Groote, Robert L Bowman, Matthew Keller, Priya Koppikar, Franck T Rapaport, Julie Teruya-Feldstein, Jorge Gandara, Christopher E Mason, Garry P Nolan, Ross L Levine
No abstract text is available yet for this article.
February 1, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29395053/clonal-hematopoiesis-and-evolution-to-hematopoietic-malignancies
#6
REVIEW
Robert L Bowman, Lambert Busque, Ross L Levine
Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood cells with one or more somatic mutations. Individuals with CH are at greater risk for hematological malignancies, cardiovascular disease, and increased mortality from non-hematological cancers. Understanding the causes of CH and how these mutant cells interact with cells of other tissues will provide critical insights into preleukemic development, stem cell biology, host-immune interactions, and cancer evolution. Here we discuss the clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states...
February 1, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29386112/traf6-mediates-basal-activation-of-nf-%C3%AE%C2%BAb-necessary-for-hematopoietic-stem-cell-homeostasis
#7
Jing Fang, Tomoya Muto, Maria Kleppe, Lyndsey C Bolanos, Kathleen M Hueneman, Callum S Walker, Leesa Sampson, Ashley M Wellendorf, Kashish Chetal, Kwangmin Choi, Nathan Salomonis, Yongwon Choi, Yi Zheng, Jose A Cancelas, Ross L Levine, Daniel T Starczynowski
Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF6 as an essential regulator of HSC homeostasis through basal activation of NF-κB. Hematopoietic-specific deletion of Traf6 resulted in impaired HSC self-renewal and fitness. Gene expression, RNA splicing, and molecular analyses of Traf6-deficient hematopoietic stem/progenitor cells (HSPCs) revealed changes in adaptive immune signaling, innate immune signaling, and NF-κB signaling, indicating that signaling via TRAF6 in the absence of cytokine stimulation and/or infection is required for HSC function...
January 30, 2018: Cell Reports
https://www.readbyqxmd.com/read/29355841/jak2-idh-mutant-driven-myeloproliferative-neoplasm-is-sensitive-to-combined-targeted-inhibition
#8
Anna Sophia McKenney, Allison N Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M Intlekofer, Jihae Ahn, Kaitlyn Shank, Franck T Rapaport, Minal A Patel, Efthymia Papalexi, Alan H Shih, April Chiu, Elizaveta Freinkman, Esra A Akbay, Mya Steadman, Raj Nagaraja, Katharine Yen, Julie Teruya-Feldstein, Kwok-Kin Wong, Raajit Rampal, Matthew G Vander Heiden, Craig B Thompson, Ross L Levine
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor outcomes. Here, we showed that combined expression of Jak2V617F and mutant IDH1R132H or Idh2R140Q induces MPN progression, alters stem/progenitor cell function, and impairs differentiation in mice. Jak2V617F Idh2R140Q-mutant MPNs were sensitive to small-molecule inhibition of IDH...
February 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29278534/cohesin-mutations-in-myeloid-malignancies-made-simple
#9
Aaron D Viny, Ross L Levine
PURPOSE OF REVIEW: Recurrent loss of function mutations within genes of the cohesin complex have been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). STAG2 is the most commonly mutated cohesin member in AML as well as solid tumors. STAG2 is recurrently, mutated in Ewing's Sarcoma, bladder cancer, and glioblastoma, and is one of only ten genes known to be recurrently mutated in over four distinct tissue types of human cancer RECENT FINDINGS: The cohesin complex, a multiprotein ring, is canonically known to align and stabilize replicated chromosomes prior to cell division...
March 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29275866/cooperative-epigenetic-remodeling-by-tet2-loss-and-nras-mutation-drives-myeloid-transformation-and-mek-inhibitor-sensitivity
#10
Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, Justin Whitfield, Kaitlyn Shank, Franck Rapaport, Rebecca Maher, Elodie Pronier, Sara C Meyer, Francine E Garrett-Bakelman, Martin Tallman, Ari Melnick, Ross L Levine, Alan H Shih
Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and NrasG12D expression in hematopoietic cells induced myeloid transformation, with a fully penetrant, lethal chronic myelomonocytic leukemia (CMML), which was serially transplantable. Tet2 loss and Nras mutation cooperatively led to decrease in negative regulators of mitogen-activated protein kinase (MAPK) activation, including Spry2, thereby causing synergistic activation of MAPK signaling by epigenetic silencing...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29249691/dual-targeting-of-oncogenic-activation-and-inflammatory-signaling-increases-therapeutic-efficacy-in-myeloproliferative-neoplasms
#11
Maria Kleppe, Richard Koche, Lihua Zou, Peter van Galen, Corinne E Hill, Lauren Dong, Sofie De Groote, Efthymia Papalexi, Amritha V Hanasoge Somasundara, Keith Cordner, Matthew Keller, Noushin Farnoud, Juan Medina, Erin McGovern, Jaime Reyes, Justin Roberts, Matthew Witkin, Franck Rapaport, Julie Teruya-Feldstein, Jun Qi, Raajit Rampal, Bradley E Bernstein, James E Bradner, Ross L Levine
Genetic and functional studies underscore the central role of JAK/STAT signaling in myeloproliferative neoplasms (MPNs). However, the mechanisms that mediate transformation in MPNs are not fully delineated, and clinically utilized JAK inhibitors have limited ability to reduce disease burden or reverse myelofibrosis. Here we show that MPN progenitor cells are characterized by marked alterations in gene regulation through differential enhancer utilization, and identify nuclear factor κB (NF-κB) signaling as a key pathway activated in malignant and non-malignant cells in MPN...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29249372/neural-coupling-between-contralesional-motor-and-frontoparietal-networks-correlates-with-motor-ability-in-individuals-with-chronic-stroke
#12
Timothy K Lam, Deirdre R Dawson, Kie Honjo, Bernhard Ross, Malcolm A Binns, Donald T Stuss, Sandra E Black, J Jean Chen, Brian T Levine, Takako Fujioka, Joyce L Chen
Movement is traditionally viewed as a process that involves motor brain regions. However, movement also implicates non-motor regions such as prefrontal and parietal cortex, regions whose integrity may thus be important for motor recovery after stroke. Importantly, focal brain damage can affect neural functioning within and between distinct brain networks implicated in the damage. The aim of this study is to investigate how resting state connectivity (rs-connectivity) within and between motor and frontoparietal networks are affected post-stroke in correlation with motor outcome...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29239838/mediator-kinase-phosphorylation-of-stat1-s727-promotes-growth-of-neoplasms-with-jak-stat-activation
#13
Ioana I Nitulescu, Sara C Meyer, Qiang Jeremy Wen, John D Crispino, Madeleine E Lemieux, Ross L Levine, Henry E Pelish, Matthew D Shair
Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on tyrosine phosphorylation of STATs, but the role of serine STAT1 phosphorylation remains unclear. We previously demonstrated that Mediator kinase inhibitor cortistatin A (CA) reduced proliferation of JAK2-mutant AML in vitro and in vivo and also suppressed CDK8-dependent phosphorylation of STAT1 at serine 727...
December 2017: EBioMedicine
https://www.readbyqxmd.com/read/29099225/gw170817-observation-of-gravitational-waves-from-a-binary-neutron-star-inspiral
#14
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, D V Atallah, P Aufmuth, C Aulbert, K AultONeal, C Austin, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, M Bailes, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, K Barkett, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, S D Barthelmy, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, M Bawaj, J C Bayley, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, S Bernuzzi, J J Bero, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, S Biscoveanu, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, E Bonilla, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, K Bossie, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, G Carullo, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, P Cerdá-Durán, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chase, E Chassande-Mottin, D Chatterjee, K Chatziioannou, B D Cheeseboro, H Y Chen, X Chen, Y Chen, H-P Cheng, H Chia, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, P Clearwater, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, D Cohen, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero-Carrión, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, G Dálya, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, N Demos, T Denker, T Dent, R De Pietri, V Dergachev, R De Rosa, R T DeRosa, C De Rossi, R DeSalvo, O de Varona, J Devenson, S Dhurandhar, M C Díaz, T Dietrich, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, C Dreissigacker, J C Driggers, Z Du, M Ducrot, R Dudi, P Dupej, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, C Fee, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, D Finstad, I Fiori, D Fiorucci, M Fishbach, R P Fisher, M Fitz-Axen, R Flaminio, M Fletcher, H Fong, J A Font, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, C Garcia-Quiros, F Garufi, B Gateley, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, B Goncharov, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, E M Gretarsson, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, O Halim, B R Hall, E D Hall, E Z Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, M Heurs, S Hild, T Hinderer, W C G Ho, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, A Hreibi, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, N K Johnson-McDaniel, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, S Karki, K S Karvinen, M Kasprzack, W Kastaun, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, K Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, M Kinley-Hanlon, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, S L Larson, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, E Leon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, S D Linker, T B Littenberg, J Liu, X Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, R Macas, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, P Marsh, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, J N Marx, K Mason, E Massera, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, L McNeill, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, B B Miller, J Miller, M Millhouse, M C Milovich-Goff, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, D Moffa, A Moggi, K Mogushi, M Mohan, S R P Mohapatra, I Molina, M Montani, C J Moore, D Moraru, G Moreno, S Morisaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A Muñiz, M Muratore, P G Murray, A Nagar, K Napier, I Nardecchia, L Naticchioni, R K Nayak, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, L Nevin, J M Newport, G Newton, K K Y Ng, P Nguyen, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, C North, L K Nuttall, J Oberling, G D O'Dea, G H Ogin, J J Oh, S H Oh, F Ohme, M A Okada, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, S Ossokine, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, Howard Pan, Huang-Wei Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, A Parida, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patil, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pirello, M Pitkin, M Poe, R Poggiani, P Popolizio, E K Porter, A Post, J Powell, J Prasad, J W W Pratt, G Pratten, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, R Prix, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, A Ramos-Buades, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, W Ren, S D Reyes, F Ricci, P M Ricker, S Rieger, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, J D Romano, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, G Rutins, K Ryan, S Sachdev, T Sadecki, L Sadeghian, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, L E Sanchez, N Sanchis-Gual, V Sandberg, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, M Scheel, J Scheuer, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, M B Shaner, L Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, L P Singer, A Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, S Somala, E J Son, J A Sonnenberg, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, K Staats, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, S P Stevenson, R Stone, D J Stops, K A Strain, G Stratta, S E Strigin, A Strunk, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, J Suresh, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, S C Tait, C Talbot, D Talukder, D B Tanner, M Tápai, A Taracchini, J D Tasson, J A Taylor, R Taylor, S V Tewari, T Theeg, F Thies, E G Thomas, M Thomas, P Thomas, K A Thorne, K S Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, A Torres-Forné, C I Torrie, D Töyrä, F Travasso, G Traylor, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, L Tsukada, D Tsuna, D Tuyenbayev, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, M Vallisneri, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, E K Wessel, P Weßels, J Westerweck, T Westphal, K Wette, J T Whelan, S E Whitcomb, B F Whiting, C Whittle, D Wilken, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Wofford, K W K Wong, J Worden, J L Wright, D S Wu, D M Wysocki, S Xiao, H Yamamoto, C C Yancey, L Yang, M J Yap, M Yazback, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, A B Zimmerman, M E Zucker, J Zweizig
On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4}  years. We infer the component masses of the binary to be between 0.86 and 2.26  M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053306/gw170814-a-three-detector-observation-of-gravitational-waves-from-a-binary-black-hole-coalescence
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B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, D V Atallah, P Aufmuth, C Aulbert, K AultONeal, C Austin, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, K Barkett, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, S D Barthelmy, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, M Bawaj, J C Bayley, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, J J Bero, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, S Biscoveanu, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, E Bonilla, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, K Bossie, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, P Cerdá-Durán, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chase, E Chassande-Mottin, D Chatterjee, K Chatziioannou, B D Cheeseboro, H Y Chen, X Chen, Y Chen, H-P Cheng, H Chia, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, P Clearwater, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, D Cohen, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero-Carrión, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, G Dálya, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, N Demos, T Denker, T Dent, R De Pietri, V Dergachev, R De Rosa, R T DeRosa, C De Rossi, R DeSalvo, O de Varona, J Devenson, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, C Dreissigacker, J C Driggers, Z Du, M Ducrot, P Dupej, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, C Fee, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, D Finstad, I Fiori, D Fiorucci, M Fishbach, R P Fisher, M Fitz-Axen, R Flaminio, M Fletcher, H Fong, J A Font, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, C Garcia-Quiros, F Garufi, B Gateley, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, B Goncharov, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, E M Gretarsson, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, O Halim, B R Hall, E D Hall, E Z Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, M Heurs, S Hild, T Hinderer, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, N K Johnson-McDaniel, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, S Karki, K S Karvinen, M Kasprzack, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, K Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, M Kinley-Hanlon, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, S D Linker, T B Littenberg, J Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, R Macas, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, P Marsh, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, K Mason, E Massera, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, L McNeill, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, B B Miller, J Miller, M Millhouse, M C Milovich-Goff, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, D Moffa, A Moggi, K Mogushi, M Mohan, S R P Mohapatra, M Montani, C J Moore, D Moraru, G Moreno, S Morisaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, A Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A Muñiz, M Muratore, P G Murray, K Napier, I Nardecchia, L Naticchioni, R K Nayak, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, L Nevin, J M Newport, G Newton, K K Y Ng, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, C North, L K Nuttall, J Oberling, G D O'Dea, G H Ogin, J J Oh, S H Oh, F Ohme, M A Okada, M Oliver, P Oppermann, R J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, S Ossokine, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, Howard Pan, Huang-Wei Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, A Parida, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patil, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pirello, M Pitkin, M Poe, R Poggiani, P Popolizio, E K Porter, A Post, J Powell, J Prasad, J W W Pratt, G Pratten, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, R Prix, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, A Ramos-Buades, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, W Ren, S D Reyes, F Ricci, P M Ricker, S Rieger, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, J D Romano, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, G Rutins, K Ryan, S Sachdev, T Sadecki, L Sadeghian, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, L E Sanchez, N Sanchis-Gual, V Sandberg, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, M Scheel, J Scheuer, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, M B Shaner, L Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, L P Singer, A Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, S Somala, E J Son, J A Sonnenberg, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, K Staats, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, S P Stevenson, R Stone, D J Stops, K A Strain, G Stratta, S E Strigin, A Strunk, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, J Suresh, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, S C Tait, C Talbot, D Talukder, D B Tanner, M Tápai, A Taracchini, J D Tasson, J A Taylor, R Taylor, S V Tewari, T Theeg, F Thies, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, A Torres-Forné, C I Torrie, D Töyrä, F Travasso, G Traylor, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, L Tsukada, D Tsuna, D Tuyenbayev, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, M Vallisneri, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, E K Wessel, P Weßels, J Westerweck, T Westphal, K Wette, J T Whelan, S E Whitcomb, B F Whiting, C Whittle, D Wilken, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Wofford, K W K Wong, J Worden, J L Wright, D S Wu, D M Wysocki, S Xiao, H Yamamoto, C C Yancey, L Yang, M J Yap, M Yazback, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, A B Zimmerman, M E Zucker, J Zweizig
On August 14, 2017 at 10∶30:43 UTC, the Advanced Virgo detector and the two Advanced LIGO detectors coherently observed a transient gravitational-wave signal produced by the coalescence of two stellar mass black holes, with a false-alarm rate of ≲1 in 27 000 years. The signal was observed with a three-detector network matched-filter signal-to-noise ratio of 18. The inferred masses of the initial black holes are 30.5_{-3.0}^{+5.7}M_{⊙} and 25.3_{-4.2}^{+2.8}M_{⊙} (at the 90% credible level). The luminosity distance of the source is 540_{-210}^{+130}  Mpc, corresponding to a redshift of z=0...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29051283/hsp90-inhibition-disrupts-jak-stat-signaling-and-leads-to-reductions-in-splenomegaly-in-patients-with-myeloproliferative-neoplasms
#16
LETTER
Gabriela S Hobbs, Amritha Varshini Hanasoge Somasundara, Maria Kleppe, Rivka Litvin, Maria Arcila, Jihae Ahn, Anna Sophia McKenney, Kristina Knapp, Ryan Ptashkin, Howard Weinstein, Murk-Hein Heinemann, Jasmine Francis, Suzanne Chanel, Ellin Berman, Michael Mauro, Martin S Tallman, Mark L Heaney, Ross L Levine, Raajit K Rampal
No abstract text is available yet for this article.
January 2018: Haematologica
https://www.readbyqxmd.com/read/28965767/jak1-integrates-cytokine-sensing-to-regulate-hematopoietic-stem-cell-function-and-stress-hematopoiesis
#17
Maria Kleppe, Matthew H Spitzer, Sheng Li, Corinne E Hill, Lauren Dong, Efthymia Papalexi, Sofie De Groote, Robert L Bowman, Matthew Keller, Priya Koppikar, Franck T Rapaport, Julie Teruya-Feldstein, Jorge Gandara, Christopher E Mason, Garry P Nolan, Ross L Levine
JAK1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in immune function, while abnormal JAK1 activity has been linked to immunological and neoplastic diseases. Specific functions of JAK1 in the context of hematopoiesis, and specifically within hematopoietic stem cells (HSCs), have not clearly been delineated. Here, we show that conditional Jak1 loss in HSCs reduces their self-renewal and markedly alters lymphoid/myeloid differentiation in vivo. Jak1-deficient HSCs exhibit decreased competitiveness in vivo and are unable to rescue hematopoiesis in the setting of myelosuppression...
October 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28945887/hybrid-capture-based-genomic-profiling-of-circulating-tumor-dna-from-patients-with-estrogen-receptor-positive-metastatic-breast-cancer
#18
J H Chung, D Pavlick, R Hartmaier, A B Schrock, L Young, B Forcier, P Ye, M K Levin, M Goldberg, H Burris, L M Gay, A D Hoffman, P J Stephens, G M Frampton, D M Lipson, D M Nguyen, S Ganesan, B H Park, L T Vahdat, B Leyland-Jones, T I Mughal, L Pusztai, J O'Shaughnessy, V A Miller, J S Ross, S M Ali
Background: Genomic changes that occur in breast cancer during the course of disease have been informed by sequencing of primary and metastatic tumor tissue. For patients with relapsed and metastatic disease, evolution of the breast cancer genome highlights the importance of using a recent sample for genomic profiling to guide clinical decision-making. Obtaining a metastatic tissue biopsy can be challenging, and analysis of circulating tumor DNA (ctDNA) from blood may provide a minimally invasive alternative...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28803919/therapy-related-clonal-hematopoiesis-in-patients-with-non-hematologic-cancers-is-common-and-associated-with-adverse-clinical-outcomes
#19
Catherine C Coombs, Ahmet Zehir, Sean M Devlin, Ashwin Kishtagari, Aijazuddin Syed, Philip Jonsson, David M Hyman, David B Solit, Mark E Robson, José Baselga, Maria E Arcila, Marc Ladanyi, Martin S Tallman, Ross L Levine, Michael F Berger
Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep-coverage, targeted, next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to assess the frequency and clinical relevance of CH in patients with non-hematologic malignancies. We identified CH in 25% of cancer patients, with 4.5% harboring presumptive leukemia driver mutations (CH-PD). CH was associated with increased age, prior radiation therapy, and tobacco use...
September 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28621973/gw170104-observation-of-a-50-solar-mass-binary-black-hole-coalescence-at-redshift-0-2
#20
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, P Aufmuth, C Aulbert, K AultONeal, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, M Bawaj, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, N M Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, D Chatterjee, K Chatziioannou, B D Cheeseboro, H Y Chen, Y Chen, H-P Cheng, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, E Deelman, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, J Devenson, R C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, J Duncan, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, H Fong, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, M Gabel, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, F Garufi, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, J Henry, A W Heptonstall, M Heurs, S Hild, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, D R Ingram, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, N K Johnson-McDaniel, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, S Kandhasamy, G Kang, J B Kanner, S Karki, K S Karvinen, M Kasprzack, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, A Libson, T B Littenberg, J Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, D V Martynov, J N Marx, K Mason, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, R Mayani, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S 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We describe the observation of GW170104, a gravitational-wave signal produced by the coalescence of a pair of stellar-mass black holes. The signal was measured on January 4, 2017 at 10∶11:58.6 UTC by the twin advanced detectors of the Laser Interferometer Gravitational-Wave Observatory during their second observing run, with a network signal-to-noise ratio of 13 and a false alarm rate less than 1 in 70 000 years. The inferred component black hole masses are 31.2_{-6.0}^{+8.4}M_{⊙} and 19.4_{-5.9}^{+5...
June 2, 2017: Physical Review Letters
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