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JOURNAL ARTICLE
Theodore Quan, Hiroko Matsumoto, Lisa Bonsignore-Opp, Brandon Ramo, Robert F Murphy, Jaysson T Brooks, Michelle C Welborn, John B Emans, Jason B Anari, Charles E Johnston, Behrooz A Akbarnia, Richard McCarthy, John Flynn, Jeffrey R Sawyer, Michael G Vitale, Benjamin D Roye
BACKGROUND: The term "Tweener" is colloquially used to refer to early-onset scoliosis (EOS) patients whose age and development make them candidates for multiple surgical options. The purpose of this study was to establish expert consensus on a definition to formally characterize the Tweener population. METHODS: A 3-round survey of surgeons in an international EOS study group was conducted. Surgeons were provided with various patient characteristics and asked if each was part of their definition for Tweener patients...
March 1, 2023: Journal of Pediatric Orthopedics
#22
JOURNAL ARTICLE
Jaejin An, Henry A Glick, Amy M Sawyer, Jessica Arguelles, Charles J Bae, Brendan T Keenan, Samuel T Kuna, Greg Maislin, Diego R Mazzotti, Allan I Pack, Jiaxiao M Shi, Alexa J Watach, Dennis Hwang
BACKGROUND: The impact of positive airway pressure (PAP) therapy for OSA on health care costs is uncertain. RESEARCH QUESTION: Are 3-year health care costs associated with PAP adherence in participants from the Tele-OSA clinical trial? STUDY DESIGN AND METHODS: Participants with OSA and prescribed PAP in the Tele-OSA study were stratified into three PAP adherence groups based on usage patterns over 3 years: (1) high (consistently ≥ 4 h/night), (2) moderate (2-3...
June 2023: Chest
#23
JOURNAL ARTICLE
Stefanie H Mueller, Alvina G Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Thais Baert, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y Brucker, Saundra S Buys, Jose E Castelao, Tsun L Chan, Jenny Chang-Claude, Stephen J Chanock, Ji-Yeob Choi, Wendy K Chung, Sarah V Colonna, Sten Cornelissen, Fergus J Couch, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Laure Dossus, Miriam Dwek, Diana M Eccles, Arif B Ekici, A Heather Eliassen, Christoph Engel, D Gareth Evans, Peter A Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat García-Closas, José A García-Sáenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guénel, Melanie Gündert, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Elaine F Harkness, Patricia A Harrington, Jaana M Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J Hooning, Reiner Hoppe, John L Hopper, Richard S Houlston, Anthony Howell, David J Hunter, Dezheng Huo, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K Khusnutdinova, Sung-Won Kim, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, Katerina Kubelka-Sabit, Allison W Kurian, Ava Kwong, James V Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A Murphy, Heli Nevanlinna, William G Newman, Dieter Niederacher, Katie M O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo I Olopade, Andrew F Olshan, Håkan Olsson, Sue K Park, Alpa V Patel, Achal Patel, Charles M Perou, Julian Peto, Paul D P Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U Rashid, Gad Rennert, Atocha Romero, Kathryn J Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Michael O Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M Tamimi, William J Tapper, Jack A Taylor, Soo Hwang Teo, Lauren R Teras, Amanda E Toland, Rob A E M Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A Troester, Thérèse Truong, Celine M Vachon, Joseph Vijai, Clarice R Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H Wu, Taiki Yamaji, Xiaohong R Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M Dunning, Douglas F Easton, Harry Hemingway, Ute Hamann, Karoline B Kuchenbaecker
BACKGROUND: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes. METHODS: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort...
January 26, 2023: Genome Medicine
#24
JOURNAL ARTICLE
Jin K Kim, Chao Wu, Michael Del Latto, Yajing Gao, Seo-Hyun Choi, Maria Kierstead, Charles-Etienne Gabriel Sauvé, Canan Firat, Almudena Chaves Perez, Jussi Sillanpaa, Chin-Tung Chen, Kayla E Lawrence, Philip B Paty, Francisco M Barriga, John E Wilkinson, Jinru Shia, Charles L Sawyers, Scott W Lowe, Julio García-Aguilar, Paul B Romesser, J Joshua Smith
We describe a mouse model of rectal cancer (RC) involving rapid tumor organoid engraftment via orthotopic transplantation in an immunocompetent setting. This approach uses simple mechanical disruption to allow engraftment, avoiding the use of dextran sulfate sodium. The resulting RC tumors invaded from the mucosal surface and metastasized to distant organs. Histologically, the tumors closely resemble human RC and mirror remodeling of the tumor microenvironment in response to radiation. This murine RC model thus recapitulates key aspects of human RC pathogenesis and presents an accessible approach for more physiologically accurate, preclinical efficacy studies...
December 19, 2022: Cell Rep Methods
#25
JOURNAL ARTICLE
Myra H Wyckoff, Robert Greif, Peter T Morley, Kee-Chong Ng, Theresa M Olasveengen, Eunice M Singletary, Jasmeet Soar, Adam Cheng, Ian R Drennan, Helen G Liley, Barnaby R Scholefield, Michael A Smyth, Michelle Welsford, David A Zideman, Jason Acworth, Richard Aickin, Lars W Andersen, Diane Atkins, David C Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W Böttiger, Richard N Bradley, Janet E Bray, Jan Breckwoldt, Clifton W Callaway, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Charles D Deakin, Therese Djärv, Michael W Donnino, Matthew J Douma, Jonathan P Duff, Cody L Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G Fabres, Joe Fawke, Judith Finn, Elizabeth E Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J Johnson, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Henry C Lee, Yiqun Jeffrey Lin, Andrew S Lockey, Ian K Maconochie, R John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J D McKinlay, Daniel Meyran, Patrick Morgan, Laurie J Morrison, Vinay Nadkarni, Firdose L Nakwa, Kevin J Nation, Ziad Nehme, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A Nuthall, Brian J O'Neill, Yong-Kwang Gene Ong, Aaron M Orkin, Edison F Paiva, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Amelia G Reis, Joshua C Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C Roehr, Mario Rüdiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L Sawyer, Steve M Schexnayder, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Takahiro Sugiura, Janice A Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M Weiner, Jonathan P Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P Nolan, Katherine M Berg
This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimising pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest...
December 2022: Resuscitation
#26
REVIEW
Myra H Wyckoff, Robert Greif, Peter T Morley, Kee-Chong Ng, Theresa M Olasveengen, Eunice M Singletary, Jasmeet Soar, Adam Cheng, Ian R Drennan, Helen G Liley, Barnaby R Scholefield, Michael A Smyth, Michelle Welsford, David A Zideman, Jason Acworth, Richard Aickin, Lars W Andersen, Diane Atkins, David C Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W Böttiger, Richard N Bradley, Janet E Bray, Jan Breckwoldt, Clifton W Callaway, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Charles D Deakin, Therese Djärv, Michael W Donnino, Matthew J Douma, Jonathan P Duff, Cody L Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G Fabres, Joe Fawke, Judith Finn, Elizabeth E Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J Johnson, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Henry C Lee, Yiqun Jeffrey Lin, Andrew S Lockey, Ian K Maconochie, R John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J D McKinlay, Daniel Meyran, Patrick Morgan, Laurie J Morrison, Vinay Nadkarni, Firdose L Nakwa, Kevin J Nation, Ziad Nehme, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A Nuthall, Brian J O'Neill, Yong-Kwang Gene Ong, Aaron M Orkin, Edison F Paiva, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Amelia G Reis, Joshua C Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C Roehr, Mario Rüdiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L Sawyer, Steve M Schexnayder, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Takahiro Sugiura, Janice A Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M Weiner, Jonathan P Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P Nolan, Katherine M Berg
This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimizing pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest...
December 20, 2022: Circulation
#27
JOURNAL ARTICLE
Astrid M Suchy-Dicey, Kyra Oziel, Charles Sawyer, Yunusa Olufadi, Tauqeer Ali, Amanda M Fretts, Jason G Umans, Dean K Shibata, W T Longstreth, Kristoffer Rhoads, Dedra S Buchwald, Thomas J Grabowski
Little is known about incidence of vascular and Alzheimer's dementias in American Indians. METHODS We conducted a large, heterogeneous, population-based, longitudinal cohort study of brain aging in community-dwelling American Indians aged 64-95 years from 11 tribes across 3 states, with neurological examinations, 1.5T magnetic resonance imaging (MRI), and extensive cognitive testing. Visit 1 in 2010-2013 (n=817) and Visit 2 in 2017-2019 (n=403) included all willing, surviving participants. Standardized cognitive tests at both visits included Modified Mini Mental Status Examination (3MSE), Wechsler Adult Intelligence Scale digit symbol coding (WAIS), Controlled Oral Word Association fas (COWA), California Verbal Learning Test short form (CVLT)...
October 26, 2022: Neurology
#28
JOURNAL ARTICLE
Madison P Wagoner, Tristan M Reyes, Virgina E Zorn, Madison M Coursen, Katie E Corbitt, Barney S Wilborn, Charles W Starkey, Terry D Brandebourg, Aeriel D Belk, Tom Bonner, Jason T Sawyer
The impact of frozen storage on beef steaks prior to the retail setting may result in changes to the quality and safety of the packaged meat. Therefore, the objective of the current study was to evaluate fresh characteristics on previously frozen steaks during a simulated retail display. Steaks were allocated to one of three packaging treatments (MB, MDF, MFS) and stored frozen (-13 °C) for 25 days in the absence of light. After thawing, steaks were stored in a lighted retail case at 3 °C and evaluated for instrumental surface color, pH, purge loss, lipid oxidation, and microbial spoilage organisms throughout the 25-day fresh display period...
September 28, 2022: Foods (Basel, Switzerland)
#29
JOURNAL ARTICLE
Andrew T McKenzie, Gabriel A Marx, Daniel Koenigsberg, Mary Sawyer, Megan A Iida, Jamie M Walker, Timothy E Richardson, Gabriele Campanella, Johannes Attems, Ann C McKee, Thor D Stein, Thomas J Fuchs, Charles L White, Kurt Farrell, John F Crary
Age-related cognitive impairment is multifactorial, with numerous underlying and frequently co-morbid pathological correlates. Amyloid beta (Aβ) plays a major role in Alzheimer's type age-related cognitive impairment, in addition to other etiopathologies such as Aβ-independent hyperphosphorylated tau, cerebrovascular disease, and myelin damage, which also warrant further investigation. Classical methods, even in the setting of the gold standard of postmortem brain assessment, involve semi-quantitative ordinal staging systems that often correlate poorly with clinical outcomes, due to imperfect cognitive measurements and preconceived notions regarding the neuropathologic features that should be chosen for study...
September 21, 2022: Acta Neuropathologica Communications
#30
JOURNAL ARTICLE
J Charles Williamson, Emily E Weatherford, Makayla M DenBeste, K Caroline Riley, Estella F Yee, Sawyer T Rogers, Clara A Tibbetts
Surface wetting phenomena impact chemistry, physics, biology, and engineering. The wetting behaviors of partially miscible binary liquid systems are especially complex. Here, we report evidence of universal behavior in the divergence of wetting layer growth at liquid-vapor interfaces of the cyclohexane + aniline, hexane + o-toluidine, and methanol + carbon disulfide systems. Layer growth on the micron scale was followed using visible light scattering from stirred samples. The layer thicknesses were found to diverge with decreasing temperature when coexistence was approached from the one-phase region, but only for solutions richer in the higher density/higher surface tension component...
August 28, 2022: Journal of Chemical Physics
#31
JOURNAL ARTICLE
Joseph M Chan, Samir Zaidi, Jillian R Love, Jimmy L Zhao, Manu Setty, Kristine M Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W Goodrich, Wouter R Karthaus, Dana Pe'er, Charles L Sawyers
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage plasticity in prostate cancer and its relationship to antiandrogen resistance. We found that plasticity initiates in an epithelial population defined by mixed luminal-basal phenotype and that it depends on increased Janus kinase (JAK) and fibroblast growth factor receptor (FGFR) activity...
September 9, 2022: Science
#32
JOURNAL ARTICLE
Koichi Ogura, Arielle Elkrief, Anita S Bowman, Richard P Koche, Elisa de Stanchina, Ryma Benayed, Audrey Mauguen, Marissa S Mattar, Inna Khodos, Paul A Meyers, John H Healey, William D Tap, Meera Hameed, Ahmet Zehir, Neerav Shukla, Charles Sawyers, Rohit Bose, Emily Slotkin, Marc Ladanyi
PURPOSE: Ewing sarcoma (ES) is a primitive sarcoma defined by EWSR1-ETS fusions as the primary driver alteration. To better define the landscape of cooperating secondary genetic alterations in ES, we analyzed clinical genomic profiling data of 113 patients with ES, a cohort including more adult patients (> 18 years) and more patients with advanced stage at presentation than previous genomic cohorts. METHODS: The data set consisted of patients with ES prospectively tested with the US Food and Drug Administration-cleared Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets large panel, hybrid capture-based next-generation sequencing assay...
August 2022: JCO Precision Oncology
#33
Jung Hwa Kim, Bogyou Kim, Ling Cai, Hee June Choi, Kenneth A Ohgi, Chris Tran, Charlie Chen, Chin Ha Chung, Otmar Huber, David W Rose, Charles L Sawyers, Michael G Rosenfeld, Sung Hee Baek
No abstract text is available yet for this article.
July 5, 2022: Nature
#34
JOURNAL ARTICLE
Tracy A Lieu, Eric P Elkin, Patricia R Escobar, Lucy Finn, Nicola P Klein, Cimone Durojaiye, Stephanie Prausnitz, Charles P Quesenberry, Debora Sawyer, Silvia Teran, Nancy Goler, Stephen M Parodi, Yi-Fen Irene Chen
Importance: COVID-19 morbidity is highest in Black and Latino older adults. These racial and ethnic groups initially had lower vaccination uptake than others, and rates in Black adults continue to lag. Objectives: To evaluate the effect of outreach via electronic secure messages and mailings from primary care physicians (PCPs) on COVID-19 vaccination uptake among Black and Latino older adults and to compare the effects of culturally tailored and standard PCP messages...
June 1, 2022: JAMA Network Open
#35
JOURNAL ARTICLE
Elizabeth V Wasmuth, Arnaud Vanden Broeck, Justin LaClair, Kayla E Lawrence, Elizabeth A Hoover, Kyrie Pappas, Biran Wang, Katia Manova-Todorova, Susan T Weintraub, Sebastian Klinge, Charles L Sawyers
The androgen receptor (AR) is the master transcription factor governing gene expression programs required for prostate epithelium development and male phenotype maintenance. AR misregulation is a hallmark of prostate cancer where AR hyperactivation and transcriptome expansion occur in part through AR amplification and interaction with oncoprotein cofactors. Despite its biological importance, how AR's domains and cofactors cooperate to bind DNA have remained elusive. We isolated three conformations of AR bound to DNA showing AR forms a non-obligate dimer, with the buried dimer interface utilized by ancestral steroid receptors repurposed to facilitate cooperative DNA binding...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#36
JOURNAL ARTICLE
Elizabeth V Wasmuth, Arnaud Vanden Broeck, Justin R LaClair, Elizabeth A Hoover, Kayla E Lawrence, Navid Paknejad, Kyrie Pappas, Doreen Matthies, Biran Wang, Weiran Feng, Philip A Watson, John C Zinder, Wouter R Karthaus, M Jason de la Cruz, Richard K Hite, Katia Manova-Todorova, Zhiheng Yu, Susan T Weintraub, Sebastian Klinge, Charles L Sawyers
The androgen receptor (AR) is a nuclear receptor that governs gene expression programs required for prostate development and male phenotype maintenance. Advanced prostate cancers display AR hyperactivation and transcriptome expansion, in part, through AR amplification and interaction with oncoprotein cofactors. Despite its biological importance, how AR domains and cofactors cooperate to bind DNA has remained elusive. Using single-particle cryo-electron microscopy, we isolated three conformations of AR bound to DNA, showing that AR forms a non-obligate dimer, with the buried dimer interface utilized by ancestral steroid receptors repurposed to facilitate cooperative DNA binding...
April 15, 2022: Molecular Cell
#37
JOURNAL ARTICLE
Madison P Wagoner, Marc R Presume, Moses E Chilenje, Gerardo A Abascal-Ponciano, Jorge L Sandoval, Hunter R Smith, Tristan M Reyes, Barney S Wilborn, Justin A Dunavant, Robert P Mason, Eric K Altom, Charles W Starkey, Jason T Sawyer
Poultry co-product chicken frames (CF) and wooden breast (WB) along with ingredient technology use may bring enhanced value to the pet food industry. Therefore, the current study focused on evaluating CF and WB combinations along with sodium alginate and encapsulated calcium lactate pentahydrate (ALGIN) inclusion within a fresh pet food formulation under simulated shelf-life conditions. Fresh chicken frames (CF) and boneless-skinless wooden breast (WB) were ground and allocated randomly to one of ten treatment combinations with either 0...
January 8, 2022: Animals: An Open Access Journal From MDPI
#38
JOURNAL ARTICLE
Joe Dennis, Jonathan P Tyrer, Logan C Walker, Kyriaki Michailidou, Leila Dorling, Manjeet K Bolla, Qin Wang, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Jose E Castelao, Jenny Chang-Claude, Georgia Chenevix-Trench, Christine L Clarke, J Margriet Collée, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Laure Dossus, A Heather Eliassen, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat García-Closas, Graham G Giles, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Per Hall, Antoinette Hollestelle, Reiner Hoppe, John L Hopper, Anthony Howell, Agnes Jager, Anna Jakubowska, Esther M John, Nichola Johnson, Michael E Jones, Audrey Jung, Rudolf Kaaks, Renske Keeman, Elza Khusnutdinova, Cari M Kitahara, Yon-Dschun Ko, Veli-Matti Kosma, Stella Koutros, Peter Kraft, Vessela N Kristensen, Katerina Kubelka-Sabit, Allison W Kurian, James V Lacey, Diether Lambrechts, Nicole L Larson, Martha Linet, Alicja Ogrodniczak, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, Roger L Milne, Taru A Muranen, Rachel A Murphy, Heli Nevanlinna, Janet E Olson, Håkan Olsson, Tjoung-Won Park-Simon, Charles M Perou, Paolo Peterlongo, Dijana Plaseska-Karanfilska, Katri Pylkäs, Gad Rennert, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Rana Shibli, Ann Smeets, Penny Soucy, Melissa C Southey, Anthony J Swerdlow, Rulla M Tamimi, Jack A Taylor, Lauren R Teras, Mary Beth Terry, Ian Tomlinson, Melissa A Troester, Thérèse Truong, Celine M Vachon, Camilla Wendt, Robert Winqvist, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Argyrios Ziogas, Jacques Simard, Alison M Dunning, Paul D P Pharoah, Douglas F Easton
Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 (P = 3.7E-18). Nine other genes were associated with a p-value < 0.01 including known susceptibility genes CHEK2 (P = 0...
January 18, 2022: Communications Biology
#39
JOURNAL ARTICLE
Shuhui Lim, Nicolas Boyer, Nicole Boo, Chunhui Huang, Gireedhar Venkatachalam, Yu-Chi Angela Juang, Michael Garrigou, Hung Yi Kristal Kaan, Ruchia Duggal, Khong Ming Peh, Ahmad Sadruddin, Pooja Gopal, Tsz Ying Yuen, Simon Ng, Srinivasaraghavan Kannan, Christopher J Brown, Chandra S Verma, Peter Orth, Andrea Peier, Lan Ge, Xiang Yu, Bhavana Bhatt, Feifei Chen, Erjia Wang, Nianyu Jason Li, Raymond J Gonzales, Alexander Stoeck, Brian Henry, Tomi K Sawyer, David P Lane, Charles W Johannes, Kaustav Biswas, Anthony W Partridge
Macrocyclic peptides have the potential to address intracellular protein-protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying this modality to intracellular targets and specifically for advancing chemical matter to address KRAS, a protein that represents the most common oncogene in human lung, colorectal and pancreatic cancers yet is one of the most challenging targets in human disease. Specifically, we focused on KRpep-2d, an arginine-rich KRAS-binding peptide with a disulfide-mediated macrocyclic linkage and a protease-sensitive backbone...
December 15, 2021: Chemical Science
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JOURNAL ARTICLE
Myra H Wyckoff, Eunice M Singletary, Jasmeet Soar, Theresa M Olasveengen, Robert Greif, Helen G Liley, David Zideman, Farhan Bhanji, Lars W Andersen, Suzanne R Avis, Khalid Aziz, Jason C Bendall, David C Berry, Vere Borra, Bernd W Böttiger, Richard Bradley, Janet E Bray, Jan Breckwoldt, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Edison F de Paiva, Charles D Deakin, Therese Djärv, Matthew J Douma, Ian R Drennan, Jonathan P Duff, Kathryn J Eastwood, Walid El-Naggar, Jonathan L Epstein, Raffo Escalante, Jorge G Fabres, Joe Fawke, Judith C Finn, Elizabeth E Foglia, Fredrik Folke, Karoline Freeman, Elaine Gilfoyle, Craig A Goolsby, Amy Grove, Ruth Guinsburg, Tetsuo Hatanaka, Mary Fran Hazinski, George S Heriot, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Kevin K C Hung, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Andrew S Lockey, Carolina Malta Hansen, David Markenson, Tasuku Matsuyama, Christopher J D McKinlay, Amin Mehrabian, Raina M Merchant, Daniel Meyran, Peter T Morley, Laurie J Morrison, Kevin J Nation, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Susan Niermeyer, Nikolaos Nikolaou, Chika Nishiyama, Brian J O'Neil, Aaron M Orkin, Osokogu Osemeke, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Joshua C Reynolds, Giuseppe Ristagno, Charles C Roehr, Tetsuya Sakamoto, Claudio Sandroni, Taylor Sawyer, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Michael A Smyth, Roger F Soll, Takahiro Sugiura, Sian Taylor-Phillips, Daniele Trevisanuto, Christian Vaillancourt, Tzong-Luen Wang, Gary M Weiner, Michelle Welsford, Jane Wigginton, Jonathan P Wyllie, Joyce Yeung, Jerry P Nolan, Katherine M Berg
The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation task force science experts...
December 2021: Resuscitation
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