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https://www.readbyqxmd.com/read/29149893/association-between-severity-of-illicit-drug-dependence-and-quality-of-life-in-a-psychosocial-care-center-in-brazil-cross-sectional-study
#1
Selva Rios Campêlo, Maria Alves Barbosa, Danilo Rocha Dias, Camila Cardoso Caixeta, Cláudio Rodrigues Leles, Celmo Celeno Porto
BACKGROUND: Quality of life must be one of the main purposes for the treatment of drug users, requiring a better understanding of the association between the quality of life and the severity of dependency. This study aimed to investigate the correlation between severity of substance use in various areas of human functioning and quality of life of illicit drug users in a psychosocial care center for alcohol and drugs. METHODS: This cross-sectional study included 60 participants - illicit drug users - treated at a psychosocial care center for alcohol and drugs...
November 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29143427/effectiveness-of-educational-program-using-printed-educational-material-on-care-burden-distress-among-staff-of-residential-aged-care-facilities-without-medical-specialists-and-or-registered-nurses-cluster-quasi-randomization-study
#2
Koji Fukuda, Seishi Terada, Mamoru Hashimoto, Katsuyuki Ukai, Ryo Kumagai, Mizue Suzuki, Masahiro Nagaya, Mika Yoshida, Hideyuki Hattori, Kenta Murotani, Kenji Toba
AIM: Behavioral and psychological symptoms of dementia are an important source of distress for caregivers. The aim of the present study was to evaluate the effectiveness of educational intervention using printed educational material for reducing distress induced by behavioral and psychological symptoms of dementia among caregivers working at facilities without medical specialists and/or registered nurses. METHODS: A cluster quasi-randomized, controlled comparative trial was carried out at 17 facilities in Japan...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29141250/a-small-supernumerary-marker-derived-from-the-pericentromeric-region-of-chromosome-5-case-report-and-delineation-of-partial-trisomy-5p-phenotype
#3
Letizia Camerota, Mariabernarda Pitzianti, Diana Postorivo, Anna M Nardone, Claudio Ligas, Costanzo Moretti, Augusto Pasini, Francesco Brancati
A 17-year-old girl presented with a distinct phenotype mainly featuring craniofacial dysmorphism, including a disproportioned large, round, elongated face; hypertelorism; deep-set eyes with short palpebral fissures; obesity (BMI 37), and a neuropsychiatric disorder with high-functioning autism. Postnatal conventional cytogenetic analyses from peripheral blood revealed a mosaic small supernumerary marker chromosome (sSMC) with a mos 47,XX,+mar[7]/46,XX[43] karyotype. By cenM-FISH technique, the sSMC was identified as a ring derivative of chromosome 5...
November 16, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29138510/high-fat-diet-induced-obesity-and-insulin-resistance-are-characterized-by-differential-beta-oscillatory-signaling-of-the-limbic-cortico-basal-ganglia-loop
#4
Lukas Maurer, Hui Tang, Jens K Haumesser, Jennifer Altschüler, Andrea A Kühn, Joachim Spranger, Christoph van Riesen
The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal role in energy homeostasis. We therefore investigated whether high-fat diet (HFD) induced obesity is associated with changes in oscillatory signaling in the limbic cortico-basal ganglia loop. We performed multi-site in-vivo electrophysiological recordings of local field potentials within this network under urethane anesthesia in adult rats after 4 weeks of HFD feeding compared to age-matched controls...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129521/diffusion-tensor-imaging-and-magnetic-resonance-spectroscopy-in-a-patient-with-adult-onset-tuberous-sclerosis-complex
#5
Hidehiro Ishikawa, Atsushi Niwa, Masaru Asahi, Keita Matsuura, Satoshi Masuzugawa, Yo Niida, Masayuki Maeda, Mineo Kondo, Hidekazu Tomimoto
Tuberous sclerosis complex (TSC) 1 or TSC2 is mutated in most TSC patients. TSC2 mutations are more frequently associated with worse outcomes, earlier age at seizure onset, more severe intellectual disability, and higher tuber load than TSC1. The degree of white matter involvement is thought to be associated with the severity of neurological impairment. At present, genotype-phenotype correlations and relationship between tuber burden and neurological disability in TSC are debatable. We presented a 43-year-old patient with TSC2 mutation, whose symptom was only incomplete quadrantic visual field deficit in spite of multiple brain tubers...
November 9, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#6
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29122459/resolution-of-anton-babinski-syndrome-after-systemic-thrombolysis-and-mechanical-thrombectomy-with-a-stentriever
#7
Giuseppe Leone, Sergio Nappini, Andrea Wlderk, Antonio Laiso, Maria Lamassa, Patrizia Nencini, Salvatore Mangiafico, Nicola Limbucci
Anton-Babinski syndrome is a rare neuropsychiatric syndrome characterized by bilateral cortical blindness and anosognosia with visual confabulation. We present the case of a patient presenting with occlusion of both posterior cerebral arteries (PCA), with Anton-Babinski syndrome, completely solved after combined systemic thrombolysis and mechanical thrombectomy with a stent-retriever.
November 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29122458/adult-onset-leukoencephalopathy-with-axonal-spheroids-and-pigmented-glia-alsp-integrating-the-literature-on-hereditary-diffuse-leukoencephalopathy-with-spheroids-hdls-and-pigmentary-orthochromatic-leukodystrophy-pold
#8
REVIEW
Scott J Adams, Andrew Kirk, Roland N Auer
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive degenerative white matter disorder. ALSP was previously recognized as two distinct entities, hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD). However, recent identification of mutations in the tyrosine kinase domain of the colony stimulating factor 1 receptor (CSF1R) gene, which regulates mononuclear cell lineages including microglia, have provided genetic and mechanistic evidence that POLD and HDLS should be regarded as a single clinicopathologic entity...
November 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29115597/quantitative-proteomic-study-of-the-plasma-reveals-acute-phase-response-and-lxr-rxr-and-fxr-rxr-activation-in-the-chronic-unpredictable-mild-stress-mouse-model-of-depression
#9
Chuangchuang Yang, Chanjuan Zhou, Jie Li, Zhi Chen, Haiyang Shi, Wensong Yang, Yinhua Qin, Lin Lü, Libo Zhao, Liang Fang, Haiyang Wang, Zicheng Hu, Peng Xie
Major depressive disorder is a severe neuropsychiatric disease that negatively impacts the quality of life of a large portion of the population. However, the molecular mechanisms underlying depression are still unclear. The pathogenesis of depression involves several brain regions. However, most previous studies have focused only on one specific brain region. Plasma and brain tissues exchange numerous components through the blood‑brain barrier. Therefore, in the present study, plasma samples from control (CON) mice and mice subjected to chronic unpredictable mild stress (CUMS) were used to investigate the molecular pathogenesis of depression, and the association between the peripheral circulation and the central nervous system...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113860/dramatic-psychiatric-and-behavioral-symptoms-following-a-subthalamic-lesion
#10
Byung Sun Choi, Guangxun Shen, Guangxian Nan, Jong-Min Kim, Ki-Young Jung, Beomseok Jeon
Neuropsychiatric symptoms have been well documented after subthalamic nucleus deep brain stimulation (STN-DBS), but those following a subthalamic lesion have been rarely reported. Herein, we present a 43-year-old woman with sudden-onset dramatic psychiatric and behavioral symptoms with hemiballism. Brain magnetic resonance imaging (MRI) with fluid attenuated inversion recovery (FLAIR) sequence during the acute phase demonstrated extensive hyperintensity in the left STN and adjacent regions. Contrast-enhanced MRI showed no abnormal areas of enhancement...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29110094/mapping-gpr88-venus-illuminates-a-novel-role-for-gpr88-in-sensory-processing
#11
Aliza T Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M Arefin, Christine Colley, Christian Le Gouill, Florence Gross, Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier, Brigitte L Kieffer
GPR88 is an orphan G-protein coupled receptor originally characterized as a striatal-enriched transcript and is a potential target for neuropsychiatric disorders. At present, gene knockout studies in the mouse have essentially focused on striatal-related functions and a comprehensive knowledge of GPR88 protein distribution and function in the brain is still lacking. Here, we first created Gpr88-Venus knock-in mice expressing a functional fluorescent receptor to fine-map GPR88 localization in the brain. The receptor protein was detected in neuronal soma, fibers and primary cilia depending on the brain region, and remarkably, whole-brain mapping revealed a yet unreported layer-4 cortical lamination pattern specifically in sensory processing areas...
November 6, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29109690/comorbid-mental-disorders-and-6-month-symptomatic-and-functioning-outcomes-in-chinese-university-students-at-clinical-high-risk-for-psychosis
#12
Jingyu Shi, Lu Wang, Yuhong Yao, Na Su, Chenyu Zhan, Ziyu Mao, Xudong Zhao
Background: High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29108272/up-regulated-expression-of-oxytocin-mrna-in-peripheral-blood-lymphocytes-from-first-episode-schizophrenia-patients
#13
Xiudeng Yang, Yamei Tang, Qinling Wei, Bing Lang, Huai Tao, Xianghui Zhang, Yong Liu, Aiguo Tang
Schizophrenia (SZ) is a severe neuropsychiatric disorder with significant social cognition impairment. Increasing evidence has suggested that neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are important mediators of complex social cognition and behavior associates with SZ. In the present study, forty-three first-episode schizophrenia (FES) patients and forty-seven healthy controls (HC) were included. The peripheral mRNA expression of OXT, OXT receptor (OXTR), AVP, AVP 1a receptor (AVPR1a) and CD38 was determined by real-time quantitative polymerase chain reaction (RT-qPCR)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102783/influence-of-intertrial-interval-on-basal-and-drug-induced-impulsive-action-in-the-5-choice-serial-reaction-time-task-effects-of-d-amphetamine-and-%C3%A2-2-5-dimethoxy-4-iodoamphetamine-doi
#14
Ciaràn M Fitzpatrick, Vojislav S Maric, Simon T Bate, Jesper T Andreasen
Impulsivity is a characteristic of a number of neuropsychiatric disorders such as attention-deficit/hyperactivity disorder. The 5-choice serial reaction time task (5-CSRTT) is a rodent paradigm extensively used to assess attention and impulsivity. Notably, 5-CSRTT studies do not typically account for the reduction in premature responding, the measure of impulsive action, occurring upon repeated exposure to test sessions with long or variable intertrial intervals (ITIs). This present 5-CSRTT study investigated the use of variable ITIs (5, 10 or 15s) across 15 test days (4 training days followed by 1 drug test day per week for three weeks) as previous experience had shown that 4 training days would be sufficient to induce consistent premature response levels in male C57BL/6J mice...
November 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29099544/catatonia-update
#15
Kanwarjeet Brar, Sachin S Kaushik, Steven Lippmann
Catatonia is a neuropsychiatric condition characterized by physical presentations ranging from profound immobility to excessive motor activity. Emotional aspects of catatonia vary clinically between psychomotor retardation and extreme excitability. In the past, catatonia was considered to be a variant of schizophrenia. However, the disorder actually occurs as a clinical expression of many different psychiatric, neurologic, or medical diagnoses. A prompt diagnostic evaluation should identify any underlying diseases with consideration of somatic pathologies, especially those affecting central nervous system function...
October 26, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29096780/an-evaluation-of-the-specificity-of-executive-function-impairment-in-developmental-psychopathology
#16
Lauren K White, Tyler M Moore, Monica E Calkins, Daniel H Wolf, Theodore D Satterthwaite, Ellen Leibenluft, Daniel S Pine, Ruben C Gur, Raquel E Gur
OBJECTIVE: Deficits in executive function (EF) are common in neuropsychiatric disorders, but the specificity of these deficits remains unclear. The aim of the present study was to elucidate the pattern of EF impairment across psychopathologies in children and adolescents. Associations among components of EF with dimensions of psychopathology, including an overall psychopathology factor, were assessed. METHOD: Participants (8-21 years) were from the Philadelphia Neurodevelopmental Cohort (N = 9,498)...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29096387/clinical-and-neuropsychological-profile-of-persons-with-mild-cognitive-impairment-a-hospital-based-study-from-a-lower-and-middle-income-country
#17
Srikala Bharath, Shilpa Sadanand, Keshav J Kumar, Rakesh Balachandar, Himanshu Joshi, Mathew Varghese
Mild Cognitive impairment (MCI) is an important pre-dementia stage to be identified towards prevention. We screened a large number of older adults seeking help at hospital and community towards a diagnosis of MCI and this study describe their clinical and neuropsychological profile. Older adults aged 60 years & above seeking help at NIMHANS outpatient & community services were screened for early cognitive deficits. Persons were diagnosed to have MCI according to Petersen's criteria, after detailed clinical and neuropsychological assessments...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29092967/gerstmann-str%C3%A3-ussler-scheinker-disease-with-atypical-presentation
#18
Sarah E Keuss, James W Ironside, Jonathan O'Riordan
We describe a 37-year-old woman who presented with progressive deafness, visual loss and ataxia. She latterly developed neuropsychiatric problems, including cognitive impairment, paranoid delusions and episodes of altered consciousness. She was found to be heterozygous for the Q212P mutation in the prion protein gene. She died over a decade after initial presentation and a diagnosis of prion disease was confirmed at postmortem.
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29090106/orofacial-involuntary-movements-in-neurosyphilis-beyond-the-candy-sign
#19
Abhishek Lenka, Naveen Thota, Albert Stezin, Pramod Kumar Pal, Ravi Yadav
BACKGROUND: Involvement of the central nervous system in patients with syphilis (neurosyphilis) may result in several neuropsychiatric symptoms. Rarely, patients with neurosyphillis may develop movement disorders with different phenomenology. Subtle orofacial dyskinesias have been reported in patients with neurosyphilis, known as the candy sign. CASE REPORT: We describe a patient with neurosyphilis who presented with severe orofacial involuntary movements. DISCUSSION: Our patient had orofacial movements at presentation and severity of the movements was much higher than the candy sign that has been reported in patients with neurosyphilis...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29074519/development-and-pilot-testing-of-a-decision-aid-for-the-initiation-of-antipsychotic-medications-in-persons-with-dementia-in-long-term-care-using-a-systematic-approach-a-study-protocol
#20
Leslie J Malloy-Weir, Andrew Kirk
INTRODUCTION: Antipsychotic medications are commonly used in long-term care to treat neuropsychiatric symptoms of dementia despite concerns that their risks (eg, infection, falls, death) may outweigh their benefits. This study protocol outlines the development and pilot testing of a decision aid for antipsychotic medications that is tailored to the information needs of residents with dementia in long-term care and family caregivers (or decision makers). The goals of the decision aid are to help residents and caregivers (1) better understand the risks and benefits of antipsychotic medications in long-term care, and (2) make informed decisions about their use (or non-use)...
October 25, 2017: BMJ Open
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