Qian Zhu, Akanksha Mishra, Joy S Park, Dongxin Liu, Derek T Le, Sasha Z Gonzalez, Morgan Anderson-Crannage, James M Park, Gun-Hoo Park, Laura Tarbay, Kamron Daneshvar, Matthew Brandenburg, Christina Signoretti, Amy Zinski, Edward-James Gardner, Kelvin L Zheng, Chiderah P Abani, Carla Hu, Cameron P Beaudreault, Xiao-Lei Zhang, Patric K Stanton, Jun-Hyeong Cho, Libor Velíšek, Jana Velíšková, Saqlain Javed, Christopher S Leonard, Hae-Young Kim, Sangmi Chung
Previously, we demonstrated the efficacy of human pluripotent stem cell (hPSC)-derived GABAergic cortical interneuron (cIN) grafts in ameliorating seizures. However, a safe and reliable clinical translation requires a mechanistic understanding of graft function, as well as the assurance of long-term efficacy and safety. By employing hPSC-derived chemically matured migratory cINs in two models of epilepsy, we demonstrate lasting efficacy in treating seizures and comorbid deficits, as well as safety without uncontrolled growth...
March 15, 2023: Neuron