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https://www.readbyqxmd.com/read/21478037/factors-associated-with-downgrading-in-patients-with-high-grade-prostate-cancer
#1
Jared M Whitson, Sima P Porten, Janet E Cowan, Jeff P Simko, Matthew R Cooperberg, Peter R Carroll
OBJECTIVE: To determine the factors associated with downgrading between biopsy and prostatectomy in the contemporary era using extended-template biopsy techniques. MATERIALS AND METHODS: The UCSF Urologic Oncology Database was used to identify subjects diagnosed with high grade prostate cancer (primary pattern 4 or 5) in at least one core on extended-pattern biopsy. Multivariable logistic regression analysis was performed to identify independent factors associated with downgrading at radical prostatectomy, defined as a change from primary pattern 4 or 5 to primary pattern 3...
May 2013: Urologic Oncology
https://www.readbyqxmd.com/read/14989132/intraoperative-radiation-therapy-in-the-multimodality-approach-to-upper-aerodigestive-tract-cancer
#2
REVIEW
Yvonne M Carter, David M Jablons, Jean B DuBois, Charles R Thomas
The cure rate of operable lung cancer and locally advanced head and neck cancer remains suboptimal, with a limited rate of local control despite improvements in the surgical removal of primary tumors and in methods for mediastinal lymph node dissection, in particular. The efficacy of adjuvant therapy, such as EBRT, has improved, and the immediate efficacy of new chemotherapeutic drugs is increasingly significant, although local recurrences remain frequent. Locoregional failure is not uncommon in upper aerodigestive tract cancers...
October 2003: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/12007936/intensity-modulated-radiotherapy-in-the-treatment-of-nasopharyngeal-carcinoma-an-update-of-the-ucsf-experience
#3
Nancy Lee, Ping Xia, Jeanne M Quivey, Khalil Sultanem, Ian Poon, Clayton Akazawa, Pam Akazawa, Vivian Weinberg, Karen K Fu
PURPOSE: To update our experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS: Between April 1995 and October 2000, 67 patients underwent IMRT for NPC at the University of California-San Francisco (UCSF). There were 20 females and 47 males, with a mean age of 49 (range 17-82). The disease was Stage I in 8 (12%), Stage II in 12 (18%), Stage III in 22 (33%), and Stage IV in 25 (37%). IMRT was delivered using three different techniques: 1) manually cut partial transmission blocks, 2) computer-controlled auto-sequencing segmental multileaf collimator (SMLC), and 3) sequential tomotherapy using a dynamic multivane intensity modulating collimator (MIMiC)...
May 1, 2002: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/11370500/uveal-melanomas-conservation-treatment
#4
REVIEW
J E Munzenrider
Eye conservation can be achieved in patients with uveal melanomas by several techniques, with external beam charged particle (proton) therapy and episcleral radionuclide plaque therapy being used most commonly. The probability of visual preservation and of eye retention with either technique is related to tumor size and location. If vision is poor or absent in the fellow eye, even very large tumors can be treated with the proton beam, with a 75% to 80% probability of eye salvage and preservation of some degree of visual function...
April 2001: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/6766795/the-role-of-radiation-therapy-in-the-management-of-ocular-reticulum-cell-sarcoma
#5
L Margolis, R Fraser, A Lichter, D H Char
Nine patients with ocular lymphomas were seen in the Department of Ophthalmology and the Division of Radiation Oncology at UCSF and Ralph K. Davies Medical Center, San Francisco, from 1978 through 1974. Six of the 9 patients had visual symptoms as the first manifestation of their disease. Eight of the 9 patients developed intracranial lymphoma at some time during the course of the disease. Despite lymphoma work-up including bone marrow biopsies and lymphangiogram, only 1 patient was found to have documented systemic involvement...
February 15, 1980: Cancer
https://www.readbyqxmd.com/read/2222244/adjuvant-chemotherapy-for-primary-lymphoma-of-the-central-nervous-system
#6
M C Chamberlain, V A Levin
Ten immunocompetent patients with primary non-Hodgkin's lymphoma of the central nervous system were treated by the neuro-oncology service at the University of California at San Francisco (UCSF). After undergoing surgery for biopsy or removal of their tumors, these patients (group 1) received irradiation with hydroxyurea followed by adjuvant chemotherapy with the combination of procarbazine, lomustine (CCNU), and vincristine. The outcome of treatment in this group was compared with that in three other groups of patients with primary CNS lymphoma: patients treated at the UCSF Cancer Research Institute who underwent surgery and radiation therapy (RT) (group 2); patients described in the literature who had surgery and RT (group 3); or patients described in the literature who had surgery, RT, and chemotherapy (group 4)...
October 1990: Archives of Neurology
https://www.readbyqxmd.com/read/2211205/radiation-therapy-for-aids-related-kaposi-s-sarcoma
#7
A M Berson, J M Quivey, J W Harris, W M Wara
Between March 1982 and October 1987, 375 fields in 187 patients with AIDS-related Kaposi's Sarcoma were treated in the Department of Radiation Oncology at the University of California in San Francisco (UCSF). Field sizes ranging from 2 x 2 cm to total skin received doses of 8 Gy in a single fraction to 15-40 Gy in 5-10 fractions. Seventy-four percent of the patients have died. Response to treatment was achieved in over 90% of treated fields, with a median time to progression of 21 months and an actuarial freedom from relapse at 6 months of 69% (97 patients alive)...
September 1990: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/2004952/hyperfractionated-irradiation-for-adults-with-brainstem-gliomas
#8
D E Linstadt, M S Edwards, M Prados, D A Larson, W M Wara
Hyperfractionated irradiation appears to have improved survival for pediatric patients with brainstem gliomas. However, the efficacy and safety of this technique are less well established for adults with brainstem tumors. In 1984 the UCSF Department of Radiation Oncology began treating adults with brainstem gliomas using 100 cGy fractions given twice daily to total doses ranging between 6600-7800 cGy (median dose 7200 cGy). By the end of 1989, a total of 14 patients had been irradiated with follow-up times for surviving patients ranging between 4-69 months (median follow-up 33 months)...
April 1991: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/1460490/primary-central-nervous-system-lymphoma-a-role-for-adjuvant-chemotherapy
#9
M C Chamberlain, V A Levin
Sixteen immunocompetent patients, 10 of whom were previously reported, with primary non-Hodgkins lymphoma of the central nervous system (PCNSL) were treated and followed longitudinally by the Neuro-oncology Service at the University of California, San Francisco (UCSF) and the University of California, San Diego (UCSD). After undergoing surgery (biopsy or resection), these patients received radiation therapy (RT) with hydroxyurea (HU) followed by adjuvant chemotherapy with the combination of procarbazine, CCNU, and vincristine (PCV) as previously reported...
November 1992: Journal of Neuro-oncology
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