Marie-Christin Metz, Ivan Ezhov, Jan C Peeken, Josef A Buchner, Jana Lipkova, Florian Kofler, Diana Waldmannstetter, Claire Delbridge, Christian Diehl, Denise Bernhardt, Friederike Schmidt-Graf, Jens Gempt, Stephanie E Combs, Claus Zimmer, Bjoern Menze, Benedikt Wiestler
BACKGROUND: The diffuse growth pattern of glioblastoma is one of the main challenges for accurate treatment. Computational tumor growth modeling has emerged as a promising tool to guide personalized therapy. Here, we performed clinical and biological validation of a novel growth model, aiming to close the gap between the experimental state and clinical implementation. METHODS: One hundred and twenty-four patients from The Cancer Genome Archive (TCGA) and 397 patients from the UCSF Glioma Dataset were assessed for significant correlations between clinical data, genetic pathway activation maps (generated with PARADIGM; TCGA only), and infiltration ( D w ) as well as proliferation (ρ) parameters stemming from a Fisher-Kolmogorov growth model...
2024: Neuro-oncology advances