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Kelly R McMahon, Maya Harel-Sterling, Michael Pizzi, Louis Huynh, Erin Hessey, Michael Zappitelli
BACKGROUND: Childhood cancer survivors treated with cisplatin, ifosfamide, or carboplatin are at risk for late kidney and blood pressure (BP) abnormalities. Few studies have comprehensively evaluated kidney outcomes and 24-h ambulatory BP monitoring (ABPM) in this population. We aimed to describe chemotherapy-associated acute kidney injury (AKI) and late kidney outcomes using standardized definitions. METHODS: This was a single-center longitudinal pilot study of 23 children who participated in a previous study during cisplatin, carboplatin, or ifosfamide treatment...
September 14, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Adriana Iturzaeta, Luis Pompozzi, Claudia Casas Rey, Irma Passarelli, Fernando Torres
INTRODUCTION: Masked hypertension (MH) in children is defined as normal office blood pressure values and high values outside the clinical setting. The 24-hour ambulatory blood pressure monitoring (ABPM) is helpful for diagnosis. There is little information on MH prevalence in our population. OBJECTIVE: To estimate the prevalence of MH in children with risk factors for arterial hypertension. MATERIAL AND METHOD: Prospective, observational, cross-sectional study...
October 1, 2018: Archivos Argentinos de Pediatría
A Sherwood, L K Hill, J A Blumenthal, A L Hinderliter
Background: The non-dipping circadian blood pressure (BP) profile is associated with both poor sleep quality and increased cardiovascular risk. The present study aimed to clarify the potential confounding effects of 24-hour ambulatory blood pressure monitoring (ABPM) used to characterize the circadian BP profile by assessing its impact on sleep quality. Methods: Participants were 121 middle-aged men and women with untreated hypertension (age=46±8 years; 43% women; 45% African American)...
September 11, 2018: American Journal of Hypertension
Fernando Manzur, Andrés Rico, Juan Diego Romero, Carlos E Rodriguez-Martinez
Objective: To evaluate the efficacy and safety of valsartan (V) or chlorthalidone (C) monotherapy in comparison with a fixed combination of valsartan and chlorthalidone (V + C). Methods: This 12-week multicenter randomized three-arm open-label study randomly allocated 72 patients to V or C as monotherapy or a combination of V + C. The aim was to measure changes in office systolic blood pressure (SBP) and diastolic blood pressure (DBP) and in 24-hour ambulatory blood pressure monitoring (ABPM) from baseline to week 12, in addition to medication tolerability...
2018: Clinical Medicine Insights. Cardiology
Moritsugu Kimura, Masao Toyoda, Moe Ono, Nobumichi Saito, Noriko Kaneyama, Masaaki Miyauchi, Tomoya Umezono, Masafumi Fukagawa
OBJECTIVE: To determine the relationship between 24-hr blood pressure (BP) fluctuations and autonomic nervous system dysfunction in diabetic patients using non-invasive ambulatory blood-pressure monitoring (ABPM) system. METHODS: The subjects were 39 diabetic patients free of cardiovascular diseases. 24-hr BP was monitored by a non-invasive ABPM system. The relationships among 24-hr BP fluctuations and various clinical parameters relevant to diabetes and hypertension were analyzed...
September 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Théo A Meister, Stefano F Rimoldi, Rodrigo Soria, Robert von Arx, Franz H Messerli, Claudio Sartori, Urs Scherrer, Emrush Rexhaj
BACKGROUND: Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown. OBJECTIVES: This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group...
September 11, 2018: Journal of the American College of Cardiology
Britta Höcker, Lutz T Weber, Ulrike John, Jens Drube, Henry Fehrenbach, Günter Klaus, Martin Pohl, Tomáš Seeman, Alexander Fichtner, Elke Wühl, Burkhard Tönshoff
BACKGROUND: Variable effects of steroid minimization strategies on blood pressure in pediatric renal transplant recipients have been reported, but data on the effect of steroid withdrawal on ambulatory blood pressure and circadian blood pressure rhythm have not been published so far. METHODS: In a prospective, randomized, multicenter study on steroid withdrawal in pediatric renal transplant recipients (n = 42) on cyclosporine, mycophenolate mofetil, and methylprednisolone, we performed a substudy in 28 patients, aged 11...
September 4, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Mohammad AbdelKader AbdelWahab, Hazem Mohammad-Ali Farrag, Cristina Eid Saied
OBJECTIVES: To investigate the association between 24-hr blood pressure variability (BPV) and subclinical echocardiographic changes and microalbuminuria in normotensive women with history of preeclampsia/eclampsia. BACKGROUND: Ambulatory blood pressure monitoring (ABPM) has been used as a valuable method in determining cardiovascular (CV) risk and target organ damage. Although hypertension and proteinuria that define preeclampsia/eclampsia may resolve in the majority of women, a significantly greater risk of CV and renal disease is present in their later life...
July 2018: Pregnancy Hypertension
Natalia V Gorach
OBJECTIVE: Introduction: Increased blood pressure is major risk factors for morbidity and mortality from coronary heart disease, stroke and heart failure. Special studies have shown that women in perimenopause are a category of high risk of cardiovascular diseases and complications developing. The aim of research was to study the effects of cimicifuga racemosa on the hemodynamics parameters and quality of life in perimenopausal women with arterial hypertension. PATIENTS AND METHODS: Materials and methods: The research involved 78 symptomatic perimenopausal women with arterial hypertension (AH) and menopausal syndrome (MS) and 30 hypertensive women with AH without MS manifestations as a control group...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Hossein Esmaeilzadeh, Sara Kashef, Hamid Reza Hatami, Soheila Alyasin, Hesamodin Nabavizadeh, Elmira Esmaeilzadeh
Allergic bronchopulmonary aspergillosis (ABPA) is the most common immunologic reaction following fungal allergen exposure in asthmatic patients. A less frequent syndrome in response to other fungal species like candida is allergic bronchopulmonary mycosis (ABPM). This reaction is mostly associated with asthma exacerbation, changes in Immunoglobulin E levels, and nonspecific findings in high resolution computed tomography (HRCT). This study presents a 9-year-old girl, a known case of childhood asthma, resolved 4 years ago as a novel case of ABPM due to Candida albicans manifested by severe emphysema, bronchiectasis, and pneumothorax which consequently required long-term treatment to get relieved...
2018: Case Reports in Immunology
Regan Fong, Charles H Ballow, Himanshu Naik, Deb Steiner, Joanne Palmer, William B White
Vixotrigine is a state- and use-dependent Nav1.7 channel blocker being investigated for the treatment of neuropathic pain conditions. This randomized, double-blind, placebo-controlled crossover trial was designed to evaluate changes in blood pressure with the administration of vixotrigine using ambulatory blood pressure monitoring (ABPM). Eligible participants were healthy adults 18 to 65 years of age without evidence of baseline systolic blood pressure (SBP) persistently > 140 mm Hg or diastolic blood pressure (DBP) persistently > 90 mm Hg...
August 24, 2018: Journal of Clinical Pharmacology
Vicente Corrêa Júnior, Flávio Danni Fuchs, Beatriz D Schaan, Leila Beltrami Moreira, Sandra Costa Fuchs, Miguel Gus
OBJECTIVE: Part of the beneficial effects of metformin on the prevention of cardiovascular events in diabetes can be attributed to pleiotropic effects, including a blood pressure (BP)-lowering effect. In a double-blind parallel clinical trial (NCT02072382), the effect of metformin on BP evaluated by ambulatory blood pressure monitoring (ABPM) was measured. METHODS: Ninety-seven patients with hypertension, but without diabetes mellitus, were randomized to receive 850-1700 mg of metformin (n = 48) or placebo (n = 49)...
August 21, 2018: Endocrine
N Y Grigoreva, M E Koroleva
OBJECTIVE: to compare hypotensive and pleiotropic effects of angiotensin II receptor blocker (ARB) azilsartan medoxomil (AM) and angiotensin converting enzyme inhibitor (ACEI) fosinopril in patients with concomitant arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: We included in this open study 49 patients with concomitant stage I-II AH and COPD. Initially all patients received hydrochlorothiazide (12.5 mg/day) and various ACEI but target blood pressure levels were not achieved, and these ACEI were withdrawn...
August 2018: Kardiologiia
Päivi M Pietilä-Effati, Anna K Salmela, M Juhani Koistinen
BACKGROUND Hypertension is a common complication of renal dialysis and is inadequately controlled in approximately one-third of patients. Intravascular renal denervation is an option to control sympathetic overdrive and decrease blood pressure. Four renal dialysis patients are presented with uncontrolled hypertension who were treated with intravascular renal denervation. CASE REPORT In a renal dialysis unit, patients were screened for therapy-resistant hypertension, which was defined as an outpatient blood pressure >160/100 mmHg and a blood pressure by interdialytic ambulatory blood pressure monitoring (ABPM) >130/80 mmHg...
August 21, 2018: American Journal of Case Reports
Kotti K, Rajeev Bagarhatta, Monicka Rathore, Prachi Bagarhatta
BACKGROUND: Ambulatory blood pressure monitoring (ABPM) in heart failure is not well defined. However, from the limited studies available, ABPM may be used to optimize heart failure therapy, and as a prognostic marker in this patient group. We analyzed the ABPM values with survival in advanced heart failure with reduced ejection fraction (HFrEF) patients who are on optimal guideline directed medical therapy (GDMT). METHODS AND RESULTS: Hundred patients of advanced HFrEF were followed up for one year...
July 2018: Indian Heart Journal
Ivo Petrov, Iveta Tasheva, Iskren Garvanski, Mihail Marzyanov, Gloria Adam
OBJECTIVE: To evaluate whether percutaneous recanalization and stenting of totally occluded renal arteries is feasible and might be justified as effective in reducing the blood pressure (BP) in some patients with preserved collateral renal flow. PATIENTS AND METHODS: Seven consecutive patients (3 women, 4 men) at average age of 42.8 years (range, 15-67 years) with resistant hypertension, high renin activity, renal artery occlusion and preserved subsegmental flow were included...
July 22, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Ercan Yuvanc, Mehmet Tolga Dogru, Vedat Simsek, Hüseyin Kandemir, Devrim Tuglu
PURPOSE: Hypertension (HT) is known to be of the main risk factors for erectile dysfunction (ED). But non-dipping (<%10 drop in the night) of HT is not investigated truly. The aim of this study was to test the hypothesis that the non-dipper hypertensive patients are more prone to develop erectile dysfunction. MATERIALS AND METHODS: This was a cross-sectional clinical study. 70 HT patients diagnosed by Ambulatory blood pressure monitoring (ABPM) were classified into 3 groups (No ED, mild to moderate and severe) according to their International Index of Erectile Function (IIEF) scores...
August 18, 2018: Urology Journal
Susanne Jung, Christian Ott, Marina V Karg, Agnes Bosch, Michael Schmid, Christian Schlundt, Stephan Achenbach, Roland E Schmieder
OBJECTIVE: In patients with resistant hypertension, percutaneous placement of an iliac arteriovenous coupler device leads to a reduction of blood pressure (BP) via decreased total vascular resistance and improved arterial compliance. However, long-term efficacy and safety need to be further explored. We report on the first case of 3.5-year follow-up in a patient who underwent implantation of an iliac arteriovenous coupler device. RESULTS: A patient with resistant hypertension was admitted to hospital...
August 14, 2018: Journal of Hypertension
Miklos Rohla, Maximilian Tscharre, Kurt Huber, Thomas W Weiss
BACKGROUND: In Austria only 41% of patients with treated hypertension (HTN) have their blood pressure (BP) controlled. This study investigated a strategy to improve BP control in primary care. METHODS: General practitioners (GPs) were randomized to interventional care vs. standard care and included patients with uncontrolled office BP > 140/90 mm Hg. In interventional care, antihypertensive therapy was up-titrated using a single pill combination (olmesartan, amlodipine and/or hydrochlorothiazde) in 4‑week intervals...
August 15, 2018: Wiener Klinische Wochenschrift
Robert E Olivo, Sarah L Hale, Clarissa J Diamantidis, Nrupen A Bhavsar, Crystal C Tyson, Katherine L Tucker, Teresa C Carithers, Bryan Kestenbaum, Paul Muntner, Rikki M Tanner, John N Booth, Stanford E Mwasongwe, Jane Pendergast, L Ebony Boulware, Julia J Scialla
Background: Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulatory BP patterns. Methods: Our study included 973 African-American adults enrolled in the Jackson Heart Study (2000-2004) with 24-hour ambulatory BP monitoring (ABPM) data at baseline. We quantified dietary phosphorus from a validated food frequency questionnaire (FFQ) as the following: 1) absolute daily intake, 2) ratio of phosphorus-to-protein intake, 3) phosphorus density, and 4) energy-adjusted phosphorus intake...
August 10, 2018: American Journal of Hypertension
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