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daphne haas-kogan

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https://www.readbyqxmd.com/read/27870572/impact-of-extent-of-resection-on-local-control-and-survival-in-patients-from-the-cog-a3973-study-with-high-risk-neuroblastoma
#1
Daniel von Allmen, Andrew M Davidoff, Wendy B London, Collin Van Ryn, Daphne A Haas-Kogan, Susan G Kreissman, Geetika Khanna, Nancy Rosen, Julie R Park, Michael P La Quaglia
Purpose This analysis of patients in the Children's Oncology Group A3973 study evaluated the impact of extent of primary tumor resection on local progression and survival and assessed concordance between clinical and central imaging review-based assessments of resection extent. Patients and Methods The analytic cohort (n = 220) included patients who had both central surgery review and resection of the primary tumor site. For this analysis, resection categories of < 90% and ≥ 90% were used, with data on resection extent derived from operating surgeons' assessments (all patients), as well as blinded central imaging review of computed tomography scans for a subset of 84 patients; assessment results were compared for concordance...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27778212/survival-after-chemotherapy-and-stem-cell-transplant-followed-by-delayed-craniospinal-irradiation-is-comparable-to-upfront-craniospinal-irradiation-in-pediatric-embryonal-brain-tumor-patients
#2
David R Raleigh, Bryan Tomlin, Benedict Del Buono, Erika Roddy, Katherine Sear, Lennox Byer, Erin Felton, Anu Banerjee, Joseph Torkildson, David Samuel, Biljana Horn, Steve E Braunstein, Daphne A Haas-Kogan, Sabine Mueller
Pediatric embryonal brain tumor patients treated with craniospinal irradiation (CSI) are at risk for adverse effects, with greater severity in younger patients. Here we compare outcomes of CSI vs. high-dose chemotherapy (HD), stem cell transplant (SCT) and delayed CSI in newly diagnosed patients. Two hundred one consecutive patients treated for medulloblastoma (72 %), supratentorial primitive neuroectodermal tumor (sPNET; 18 %) or pineoblastoma (10 %) at two institutions between 1988 and 2014 were retrospectively identified...
October 24, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27683733/pediatric-low-grade-gliomas-implications-of-the-biologic-era
#3
Roger J Packer, Stephan Pfister, Eric Bouffet, Robert Avery, Pratiti Bandopadhayay, Miriam Bornhorst, Daniel C Bowers, David Ellison, Jason Fangusaro, Nicholas Foreman, Maryam Fouladi, Amar Gajjar, Daphne Haas-Kogan, Cynthia Hawkins, Cheng-Ying Ho, Eugene Hwang, Nada Jabado, Lindsay B Kilburn, Alvaro Lassaletta, Keith L Ligon, Maura Massimino, Schouten-van Meeteren, Sabine Mueller, Theo Nicolaides, Giorgio Perilongo, Uri Tabori, Gilbert Vezina, Katherine Warren, Olaf Witt, Yuan Zhu, David T Jones, Mark Kieran
For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular signaling in the Ras-mitogen-activated protein kinase pathway. The conclusions and recommendations of a consensus conference of how best to integrate the growing body of molecular genetic information into tumor classifications and, more importantly, for future treatment of pediatric LGGs are summarized here. There is uniform agreement that molecular characterization must be incorporated into classification and is increasingly critical for appropriate management...
September 28, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27571885/chemotherapy-for-adult-low-grade-gliomas-clinical-outcomes-by-molecular-subtype-in-a-phase-ii-study-of-adjuvant-temozolomide
#4
Michael Wahl, Joanna J Phillips, Annette M Molinaro, Yi Lin, Arie Perry, Daphne A Haas-Kogan, Joseph F Costello, Manisha Dayal, Nicholas Butowski, Jennifer L Clarke, Michael Prados, Sarah Nelson, Mitchel S Berger, Susan M Chang
BACKGROUND: Optimal adjuvant management of adult low-grade gliomas is controversial. Recently described tumor classification based on molecular subtype has the potential to individualize adjuvant therapy but has not yet been evaluated as part of a prospective trial. METHODS: Patients aged 18 or older with newly diagnosed World Health Organization grade II low-grade gliomas and gross residual disease after surgical resection were enrolled in the study. Patients received monthly cycles of temozolomide for up to 1 year or until disease progression...
August 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27540084/presence-of-cerebral-microbleeds-is-associated-with-worse-executive-function-in-pediatric-brain-tumor-survivors
#5
Erika Roddy, Katherine Sear, Erin Felton, Benita Tamrazi, Karen Gauvain, Joseph Torkildson, Benedict Del Buono, David Samuel, Daphne A Haas-Kogan, Josephine Chen, Robert E Goldsby, Anuradha Banerjee, Janine M Lupo, Annette M Molinaro, Heather J Fullerton, Sabine Mueller
BACKGROUND: A specific form of small-vessel vasculopathy-cerebral microbleeds (CMBs)-has been linked to various types of dementia in adults. We assessed the incidence of CMBs and their association with neurocognitive function in pediatric brain tumor survivors. METHODS: In a multi-institutional cohort of 149 pediatric brain tumor patients who received cranial radiation therapy (CRT) between 1987 and 2014 at age <21 years and 16 patients who did not receive CRT, we determined the presence of CMBs on brain MRIs...
November 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27370397/inhibition-of-dna-damage-repair-by-the-cdk4-6-inhibitor-palbociclib-delays-irradiated-intracranial-atypical-teratoid-rhabdoid-tumor-and-glioblastoma-xenograft-regrowth
#6
Rintaro Hashizume, Ali Zhang, Sabine Mueller, Michael D Prados, Rishi R Lulla, Stewart Goldman, Amanda M Saratsis, Andrew P Mazar, Alexander H Stegh, Shi-Yuan Cheng, Craig Horbinski, Daphne A Haas-Kogan, Jann N Sarkaria, Todd Waldman, C David James
BACKGROUND: Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating the efficacy of chemotherapeutics combined with radiation for treating malignant brain tumors is of high clinical relevance. In this study, we examined the cyclin-dependent kinase 4/6 inhibitor palbociclib, when used in combination with radiation for treating human atypical teratoid rhabdoid tumor (ATRT) as well as glioblastoma (GBM). METHODS: Evaluation of treatment antitumor activity in vitro was based upon results from cell proliferation assays, clonogenicity assays, flow cytometry, and immunocytochemistry for DNA double-strand break repair...
November 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27282398/pediatric-high-grade-glioma-biologically-and-clinically-in-need-of-new-thinking
#7
Chris Jones, Matthias A Karajannis, David T W Jones, Mark W Kieran, Michelle Monje, Suzanne J Baker, Oren J Becher, Yoon-Jae Cho, Nalin Gupta, Cynthia Hawkins, Darren Hargrave, Daphne A Haas-Kogan, Nada Jabado, Xiao-Nan Li, Sabine Mueller, Theo Nicolaides, Roger J Packer, Anders I Persson, Joanna J Phillips, Erin F Simonds, James M Stafford, Yujie Tang, Stefan M Pfister, William A Weiss
High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma...
June 9, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27282397/histopathologic-review-of-pineal-parenchymal-tumors-identifies-novel-morphologic-subtypes-and-prognostic-factors-for-outcome
#8
David R Raleigh, David A Solomon, Shane A Lloyd, Ann Lazar, Michael A Garcia, Penny K Sneed, Jennifer L Clarke, Michael W McDermott, Mitchel S Berger, Tarik Tihan, Daphne A Haas-Kogan
BACKGROUND: Pineal parenchymal tumors (PPTs) are rare neoplasms of the central nervous system, and data concerning clinical outcomes are limited. The purpose of this study was to define the clinical behavior of PPT according to current histopathologic criteria and identify prognostic factors to guide therapeutic decisions. METHODS: Seventy-five patients treated for PPT at a single institution between 1992 and 2015 were retrospectively identified. Forty-five resection specimens were available and re-reviewed...
June 9, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27217440/braf-status-in-personalizing-treatment-approaches-for-pediatric-gliomas
#9
Aleksandra Olow, Sabine Mueller, Xiaodong Yang, Rintaro Hashizume, Justin Meyerowitz, William Weiss, Adam C Resnick, Angela J Waanders, Lukas J A Stalpers, Mitchel S Berger, Nalin Gupta, C David James, Claudia K Petritsch, Daphne A Haas-Kogan
PURPOSE: Alteration of the BRAF/MEK/MAPK pathway is the hallmark of pediatric low-grade gliomas (PLGGs), and mTOR activation has been documented in the majority of these tumors. We investigated combinations of MEK1/2, BRAF(V600E) and mTOR inhibitors in gliomas carrying specific genetic alterations of the MAPK pathway. EXPERIMENTAL DESIGN: We used human glioma lines containing BRAF(V600E) (adult high-grade: AM-38, DBTRG, PLGG: BT40), or wild-type BRAF (pediatric high-grade: SF188, SF9427, SF8628) and isogenic systems of KIAA1549:BRAF-expressing NIH/3T3 cells and BRAF(V600E)-expressing murine brain cells...
November 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27072750/exploiting-molecular-biology-for-diagnosis-and-targeted-management-of-pediatric-low-grade-gliomas
#10
Michael A Garcia, David A Solomon, Daphne A Haas-Kogan
The majority of brain tumors arising in children are low-grade gliomas. Although historically categorized together as pediatric low-grade gliomas (PLGGs), there is significant histologic and genetic diversity within this group. In general, prognosis for PLGGs is excellent, and limitation of sequelae from tumor and treatment is paramount. Advances in high-throughput genetic sequencing and gene expression profiling are fundamentally changing the way PLGGs are classified and managed. Here, we review the histologic subtypes and highlight how recent advances in elucidating the molecular pathogenesis of these tumors have refined diagnosis and prognostication...
June 2016: Future Oncology
https://www.readbyqxmd.com/read/26950597/therapeutic-radiation-and-the-potential-risk-of-second-malignancies
#11
REVIEW
Sophia C Kamran, Amy Berrington de Gonzalez, Andrea Ng, Daphne Haas-Kogan, Akila N Viswanathan
Radiation has long been associated with carcinogenesis. Nevertheless, it is an important part of multimodality therapy for many malignancies. It is critical to assess the risk of secondary malignant neoplasms (SMNs) after radiation treatment. The authors reviewed the literature with a focus on radiation and associated SMNs for primary hematologic, breast, gynecologic, and pediatric tumors. Radiation appeared to increase the risk of SMN in all of these; however, this risk was found to be associated with age, hormonal influences, chemotherapy use, environmental influences, genetic predisposition, infection, and immunosuppression...
June 15, 2016: Cancer
https://www.readbyqxmd.com/read/26829751/myb-qki-rearrangements-in-angiocentric-glioma-drive-tumorigenicity-through-a-tripartite-mechanism
#12
Pratiti Bandopadhayay, Lori A Ramkissoon, Payal Jain, Guillaume Bergthold, Jeremiah Wala, Rhamy Zeid, Steven E Schumacher, Laura Urbanski, Ryan O'Rourke, William J Gibson, Kristine Pelton, Shakti H Ramkissoon, Harry J Han, Yuankun Zhu, Namrata Choudhari, Amanda Silva, Katie Boucher, Rosemary E Henn, Yun Jee Kang, David Knoff, Brenton R Paolella, Adrianne Gladden-Young, Pascale Varlet, Melanie Pages, Peleg M Horowitz, Alexander Federation, Hayley Malkin, Adam A Tracy, Sara Seepo, Matthew Ducar, Paul Van Hummelen, Mariarita Santi, Anna Maria Buccoliero, Mirko Scagnet, Daniel C Bowers, Caterina Giannini, Stephanie Puget, Cynthia Hawkins, Uri Tabori, Almos Klekner, Laszlo Bognar, Peter C Burger, Charles Eberhart, Fausto J Rodriguez, D Ashley Hill, Sabine Mueller, Daphne A Haas-Kogan, Joanna J Phillips, Sandro Santagata, Charles D Stiles, James E Bradner, Nada Jabado, Alon Goren, Jacques Grill, Azra H Ligon, Liliana Goumnerova, Angela J Waanders, Phillip B Storm, Mark W Kieran, Keith L Ligon, Rameen Beroukhim, Adam C Resnick
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI...
March 2016: Nature Genetics
https://www.readbyqxmd.com/read/26782702/erratum-to-survival-advantage-combining-a-braf-inhibitor-and-radiation-in-braf-v600e-mutant-glioma
#13
Tina Dasgupta, Aleksandra K Olow, Xiaodong Yang, Rintaro Hashizume, Theodore P Nicolaides, Maxwell Tom, Yasuyuki Aoki, Mitchel S Berger, William A Weiss, Lukas J A Stalpers, Michael Prados, C David James, Sabine Mueller, Daphne A Haas-Kogan
No abstract text is available yet for this article.
February 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26493740/clinical-outcome-and-prognostic-factors-for-central-neurocytoma-twenty-year-institutional-experience
#14
Brandon S Imber, Steve E Braunstein, Fred Y Wu, Nima Nabavizadeh, Nicholas Boehling, Vivian K Weinberg, Tarik Tihan, Michael Barnes, Sabine Mueller, Nicholas A Butowski, Jennifer L Clarke, Susan M Chang, Michael M McDermott, Michael D Prados, Mitchel S Berger, Daphne A Haas-Kogan
Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS) was measured by Kaplan-Meier and Cox proportional hazards methods. A total of 28 patients (15 males, 13 females) were treated between 1995 and 2014, with a median age at diagnosis of 26 years (range 5-61)...
January 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26410347/multi-institutional-implementation-and-evaluation-of-a-curriculum-for-the-medical-student-clerkship-in-radiation-oncology
#15
Daniel W Golden, Steve Braunstein, Rachel B Jimenez, Pranshu Mohindra, Alexander Spektor, Jason C Ye
PURPOSE: Radiation oncology curriculum development is challenging because of limited numbers of trainees at any single institution. The goal of this project is to implement and evaluate a standardized medical student clerkship curriculum following the multi-institutional cooperative group research model. METHODS: During the 2013 academic year, a standardized curriculum was implemented at 11 academic medical centers consisting of three 1-hour lectures and a hands-on radiation treatment planning workshop...
February 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/26384810/survival-advantage-combining-a-braf-inhibitor-and-radiation-in-braf-v600e-mutant-glioma
#16
Tina Dasgupta, Aleksandra K Olow, Xiaodong Yang, Rintaro Hashizume, Theodore P Nicolaides, Maxwell Tom, Yasuyuki Aoki, Mitchel S Berger, William A Weiss, Lukas J A Stalpers, Michael Prados, C David James, Sabine Mueller, Daphne A Haas-Kogan
Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E inhibitor, enhances the activity of RT in human HGGs in vitro and in vivo. Patient-derived HGG lines harboring wild-type BRAF or BRAF V600E were assessed in vitro to determine IC50 values, cell cycle arrest, apoptosis and senescence and elucidate mechanisms of combinatorial activity...
February 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26215953/wee1-kinase-as-a-target-for-cancer-therapy
#17
COMMENT
Sabine Mueller, Daphne A Haas-Kogan
No abstract text is available yet for this article.
October 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25968822/medical-student-perspectives-on-a-multi-institutional-clerkship-curriculum-a-report-from-the-radiation-oncology-education-collaborative-study-group
#18
Jason C Ye, Pranshu Mohindra, Alexander Spektor, Monica S Krishnan, Steven J Chmura, Andrew R Howard, Akila N Viswanathan, Shannon M MacDonald, Nikhil G Thaker, Prajnan Das, Brandon R Mancini, Susan A Higgins, Steve Braunstein, Daphne Haas-Kogan, Kristin A Bradley, Arthur Y Hung, Charles R Thomas, Jordan Kharofa, Matt Wheatley, Adam Currey, Bhupesh Parashar, Kevin Du, Rachel B Jimenez, Daniel W Golden
No abstract text is available yet for this article.
June 1, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25896312/long-term-side-effects-of-radiotherapy-for-pediatric-localized-neuroblastoma-results-from-clinical-trials-nb90-and-nb94
#19
MULTICENTER STUDY
Anne Ducassou, Marion Gambart, Caroline Munzer, Laetitia Padovani, Christian Carrie, Daphne Haas-Kogan, Valérie Bernier-Chastagner, Charlotte Demoor, Line Claude, Sylvie Helfre, Stéphanie Bolle, Julie Leseur, Aymeri Huchet, Hervé Rubie, Dominique Valteau-Couanet, Gudrun Schleiermacher, Carole Coze, Anne-Sophie Defachelles, Aurélien Marabelle, Stéphane Ducassou, Christine Devalck, Virginie Gandemer, Martine Munzer, Anne Laprie
INTRODUCTION: Neuroblastoma (NB) is the most frequent indication for extracranial pediatric radiotherapy. As long-term survival of high-risk localized NB has greatly improved, we reviewed treatment-related late toxicities in pediatric patients who received postoperative radiotherapy (RT) for localized NB within two French prospective clinical trials: NB90 and NB94. PATIENTS AND METHODS: From 1990-2000, 610 children were enrolled. Among these, 35 were treated with induction chemotherapy, surgery, and RT...
July 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/25695691/phase-i-study-of-vorinostat-as-a-radiation-sensitizer-with-131i-metaiodobenzylguanidine-131i-mibg-for-patients-with-relapsed-or-refractory-neuroblastoma
#20
MULTICENTER STUDY
Steven G DuBois, Susan Groshen, Julie R Park, Daphne A Haas-Kogan, Xiaodong Yang, Ethan Geier, Eugene Chen, Kathy Giacomini, Brian Weiss, Susan L Cohn, M Meaghan Granger, Gregory A Yanik, Randall Hawkins, Jesse Courtier, Hollie Jackson, Fariba Goodarzian, Hiroyuki Shimada, Scarlett Czarnecki, Denice Tsao-Wei, Judith G Villablanca, Araz Marachelian, Katherine K Matthay
PURPOSE: (131)I-metaiodobenzylguanidine (MIBG) is a radiopharmaceutical with activity in neuroblastoma. Vorinostat is a histone deacetylase inhibitor that has radiosensitizing properties. The goal of this phase I study was to determine the MTDs of vorinostat and MIBG in combination. EXPERIMENTAL DESIGN: Patients ≤ 30 years with relapsed/refractory MIBG-avid neuroblastoma were eligible. Patients received oral vorinostat (dose levels 180 and 230 mg/m(2)) daily days 1 to 14...
June 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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