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https://www.readbyqxmd.com/read/28282791/anti-arthritic-effect-of-berberine-on-adjuvant-induced-rheumatoid-arthritis-in-rats
#1
Xue Wang, Xin He, Chun-Feng Zhang, Chang-Run Guo, Chong-Zhi Wang, Chun-Su Yuan
BACKGROUND: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease, which affects approximately 1% adult population in the worldwide. AIM: The present study was to investigate the anti-arthritic effect of berberine and its involved mechanism in Freund's complete adjuvant (FCA) induced arthritis rats. METHODS AND MATERIALS: Rats were divided randomly into control, FCA, tripterysium glycosides, berberine (75 and 150mg/kg). The apparent indicators, including changes of body weights, paw swelling degrees and arthritis indexes, were analyzed to evaluate anti-arthritic effect of berberine...
March 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28282539/increasing-podiatry-referrals-for-patients-with-inflammatory-arthritis-at-a-tertiary-hospital-in-singapore-a-quality-improvement-project
#2
K Carter, P P Cheung, K Rome, A Santosa, M Lahiri
BACKGROUND: Foot disease is highly prevalent in people with inflammatory arthritis and is often under-recognized. Podiatry intervention can significantly reduce foot pain and disability, with timely access being the key factor. The aim of this study was to plan and implement a quality improvement project to identify the barriers to, and improve, uptake of podiatry services among patients with inflammatory arthritis-related foot problems seen at a tertiary hospital in Singapore. METHOD: A 6-month quality improvement program was conducted by a team of key stakeholders using quality improvement tools to identify, implement and test several interventions designed to improve uptake of podiatry services...
December 28, 2016: Foot
https://www.readbyqxmd.com/read/28261425/intermittent-pneumatic-compression-for-the-prevention-of-venous-thromboembolism-after-total-hip-arthroplasty
#3
Hong Suk Kwak, Jai Ho Cho, Jung Taek Kim, Jeong Joon Yoo, Hee Joong Kim
BACKGROUND: Venous thromboembolism (VTE) is a relatively common and potentially life threatening complication after major hip surgery. There are two main types of prophylaxis: chemical and mechanical. Chemical prophylaxis is very effective but causes bleeding complications in surgical wounds and remote organs. On the other hand, mechanical methods are free of hemorrhagic complications but are less effective. We hypothesized that mechanical prophylaxis is effective enough for Asians in whom VTE occurs less frequently...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28225220/efficacy-of-ruscus-extract-hmc-and-vitamin-c-constituents-of-cyclo-3-fort%C3%A2-on-improving-individual-venous-symptoms-and-edema-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#4
Stavros K Kakkos, François A Allaert
INTRODUCTION: Venoactive drugs (VADs) are considered an important component of the medical (conservative) treatment of chronic venous disorders (CVDs). However, the efficacy of certain VADs on one or more individual leg symptoms may have not been extensively studied to justify a high level or grade of recommendation in guidelines on CVD. The aim of the present systematic review and meta-analysis was to study the effectiveness of VADs containing Ruscus across the spectrum of defined venous symptoms...
April 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#5
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28116268/pseudoaneurysm-of-the-posterior-tibial-artery-following-removal-of-tibial-plate-a-rare-case
#6
Salman Ghaffari, Hossein Farsavian, Seyed Mohamad Mehdi Daneshpoor, Masoud Shayesteh
INTRODUCTION: Pseudoaneurysm is a rare complication reported after any surgery such as ORIF of fracture, plate removal, ankle or knee arthroscopy or arthroplasty. To our knowledge, pseudoaneurysms of the posterior tibial artery after tibial plate removal are a rare phenomenon. We report a case of a 18-year-old male patient who had pseudoaneurysm of posterior tibial artery following plate removal. CASE PRESENTATION: A 18-year-old male was referred to our outpatient clinic because of mass-like lesion in his left calf...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28053200/treatment-and-prevention-of-acute-and-recurrent-ankle-sprain-an-overview-of-systematic-reviews-with-meta-analysis
#7
Cailbhe Doherty, Chris Bleakley, Eamonn Delahunt, Sinead Holden
BACKGROUND: Ankle sprains are highly prevalent with high risk of recurrence. Consequently, there are a significant number of research reports examining strategies for treating and preventing acute and recurrent sprains (otherwise known as chronic ankle instability (CAI)), with a coinciding proliferation of review articles summarising these reports. OBJECTIVE: To provide a systematic overview of the systematic reviews evaluating treatment strategies for acute ankle sprain and CAI...
January 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28045417/complex-regional-pain-syndrome-after-transfemoral-coronary-balloon-angioplasty
#8
Rohan Pravinbhai Parikh, Pradeep Deshmukh
Presently described is the case of a 55-year-old man who developed localized pain, allodynia, hyperpathia, and swelling over the right ankle joint following coronary balloon angioplasty, which had been performed via right femoral arterial access. Bone scan confirmed the diagnosis of complex regional pain syndrome. Various analgesics were administered, along with physiotherapist-assisted exercise. The present is the first reported case of complex regional pain syndrome presenting as remote postprocedural complication of transfemoral coronary balloon angioplasty...
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28042750/pseudo-aneurysm-a-rare-complication-of-ankle-arthroscopy
#9
Mathew Davis, David Brooks, William Bryceson
A 53-year-old woman underwent arthroscopic ankle debridement for posttraumatic arthrofibrosis 2 years following a bimalleolar ankle fracture. Twelve months postarthroscopy, the patient returned to physical therapy with a 2-week history of pain and prominent swelling to her anterior ankle. Urgent follow-up was arranged with an orthopaedic surgeon, who ordered a radiograph and magnetic resonance imaging, which demonstrated a large heterogeneous mass. Doppler ultrasound was also ordered and confirmed the mass to be a pseudo-aneurysm of the anterior tibial artery...
January 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27943552/usefulness-of-a-simple-self-administered-joint-condition-assessment-sheet-to-predict-the-need-for-orthopaedic-intervention-in-the-management-of-haemophilic-arthropathy
#10
T Masaoka, K Amano, H Takedani, T Suzuki, M Otaki, I Seita, T Tateiwa, T Shishido, K Yamamoto, K Fukutake
INTRODUCTION: Detecting signs of joint deterioration is important for early effective orthopaedic intervention in managing haemophilic arthropathy. AIM: We developed a simple, patient self-administered sheet to evaluate the joint condition, and assessed the predictive ability of this assessment sheet for the need for an orthopaedic intervention. METHODS: This was a single-centre, cross-sectional study. The association between the score of each of the four items of the assessment sheet (bleeding, swelling, pain and physical impairment) and the results of radiological findings and physical examinations based on Haemophilia Joint Health Score 2...
December 11, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27927257/unusual-diagnosis-in-a-patient-with-minor-ankle-trauma
#11
Zoë Piggott, Donna Clark
We present the case of a 23 year-old male who sustained an anterior tibial artery pseudoaneurysm after an apparently innocuous soccer injury. The patient presented with sudden onset severe pain and swelling one week after the injury. The diagnosis was made using duplex ultrasound, and confirmed with CT angiography. Definitive management consisted of endovascular platinum microcoiling. One year later, the patient is asymptomatic and remains active. A review of the epidemiology, diagnosis, and treatment of arterial pseudoaneurysm is presented...
December 8, 2016: CJEM
https://www.readbyqxmd.com/read/27919937/primary-care-referral-for-echocardiogram-refer-in-heart-failure-a-diagnostic-accuracy-study
#12
Clare J Taylor, Andrea K Roalfe, Rachel Iles, Fd Richard Hobbs, P Barton, J Deeks, D McCahon, M R Cowie, G Sutton, R C Davis, J Mant, T McDonagh, L Tait
BACKGROUND: Symptoms of breathlessness, fatigue, and ankle swelling are common in general practice but deciding which patients are likely to have heart failure is challenging. AIM: To evaluate the performance of a clinical decision rule (CDR), with or without N-Terminal pro-B type natriuretic peptide (NT-proBNP) assay, for identifying heart failure. DESIGN AND SETTING: Prospective, observational, diagnostic validation study of patients aged >55 years, presenting with shortness of breath, lethargy, or ankle oedema, from 28 general practices in England...
February 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27903576/first-reported-case-of-peroneal-tenosynovitis-caused-by-coccidioides-immitis-successfully-treated-with-fluconazole
#13
Aneela Majeed, Waqas Ullah, Auon Abbas Hamadani, Anca Georgescu
Coccidioidomycosis is an insidious infection caused by Coccidioides spp (C. immitis and C. posadasii). Disseminated disease occasionally involves tendon sheaths and synovium of the joints leading to tenosynovitis. Here, we describe the case of a 72-year-old woman from southern Arizona, who presented with right ankle pain, redness and swelling for 2 months. Her serum IgG was positive for C. immitis on complement fixation, and her MRI of the right ankle joint showed extensive tenosynovitis of the right peroneal tendons, and subtalar joint effusions with associated synovitis...
November 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27885357/achilles-tendinopathy-current-concepts-about-the-basic-science-and-clinical-treatments
#14
REVIEW
Hong-Yun Li, Ying-Hui Hua
Achilles tendinopathy is one of the most frequently ankle and foot overuse injuries, which is a clinical syndrome characterized by the combination of pain, swelling, and impaired performance. The two main categories of Achilles tendinopathy are classified according to anatomical location and broadly include insertional and noninsertional tendinopathy. The etiology of Achilles tendinopathy is multifactorial including both intrinsic and extrinsic factors. Failed healing response and degenerative changes were found in the tendon...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27851983/osteopontin-inhibition-of-mir-129-3p-enhances-il-17-expression-and-monocyte-migration-in-rheumatoid-arthritis
#15
Chun-Hao Tsai, Shan-Chi Liu, Yu-Han Wang, Chen-Ming Su, Chien-Chung Huang, Chin-Jung Hsu, Chih-Hsin Tang
BACKGROUND: Osteopontin (OPN) is an important proinflammatory cytokine in rheumatoid arthritis (RA). Levels of OPN have been shown to be significantly correlated with interleukin-17 (IL-17) production and expression of Th17 cells in the synovial fluid of RA patients. Here, we investigated the role of OPN in monocyte migration, IL-17 production and osteoblasts. METHODS: OPN and IL-17 expression profiles in osteoarthritis (OA) and RA synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA)...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27826329/recurrent-macrophage-activation-syndrome-since-toddler-age-in-an-adolescent-boy-with-hla-b27-positive-juvenile-ankylosing-spondylitis
#16
Joon Hyeong Park, Yu Mi Seo, Seung Beom Han, Ki Hwan Kim, Jung Woo Rhim, Nack Gyun Chung, Myung Shin Kim, Jin Han Kang, Dae Chul Jeong
Recurrent macrophage activation syndrome (MAS) is very rare. We present the case of an adolescent boy with human leukocyte antigen (HLA) B27-positive ankylosing spondylitis (AS), who experienced episodes of recurrent MAS since he was a toddler. A 16-year-old boy was admitted because of remittent fever with pancytopenia and splenomegaly after surgical intervention for an intractable perianal abscess. He had been diagnosed with hemophagocytic lymphohistiocytosis (HLH) 4 different times, which was well controlled with intravenous immunoglobulin and steroids since the age of 3...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27802849/miliary-tuberculosis-and-acquired-immunodeficiency-syndrome-a-cursed-duet
#17
Atif Tatari, Sahana Ramanujam, Suja Mathai, Nigahus Karabulut, Robert L Moser, Sara L Wallach
Tuberculous osteomyelitis is rare and usually involves the vertebrae but is seldom found in the foot. The uncommon site and ability to mimic other disorders clinically and radiographically leads to diagnostic and therapeutic delays. We report a case of a 40-year-old man who initially presented to his podiatrist with intermittent pain and swelling of his right ankle and foot that lasted for a year. He also started to exhibit significant weight loss and unexplained fevers and was subsequently hospitalized for cellulitis of his right foot...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27776554/s100a8-a9-a-potent-serum-and-molecular-imaging-biomarker-for-synovial-inflammation-and-joint-destruction-in-seronegative-experimental-arthritis
#18
Edwin J W Geven, Martijn H J van den Bosch, Irene Di Ceglie, Giuliana Ascone, Shahla Abdollahi-Roodsaz, Annet W Sloetjes, Sven Hermann, Michael Schäfers, Fons A J van de Loo, Peter M van der Kraan, Marije I Koenders, Dirk Foell, Johannes Roth, Thomas Vogl, Peter L E M van Lent
BACKGROUND: Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthritides. In this study, we investigated the biomarker potential of systemic and local levels of these S100 proteins to assess joint inflammation and joint destruction in an experimental model for seronegative arthritis...
October 24, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27775097/involvement-of-p2x7-receptor-signaling-on-regulating-the-differentiation-of-th17-cells-and-type-ii-collagen-induced-arthritis-in-mice
#19
Zhi-Dan Fan, Ya-Yuan Zhang, Yi-Hong Guo, Na Huang, Hui-Hui Ma, Hui Huang, Hai-Guo Yu
Interleukin (IL)-17 producing T helper (Th17) cells are major effector cells in the pathogenesis of rheumatoid arthritis (RA). The P2X7 receptor (P2X7R) has emerged as a potential site in the regulation of inflammation in RA but little is known of its functional role on the differentiation of Th17 cells. This study investigates the in vitro and in vivo effects of P2X7R on Th17 cell differentiation during type II collagen (CII) induced experimental arthritis model. In CII-treated dendritic cells (DCs) and DC/CD4(+) T coculture system, pretreatment with pharmacological antagonists of P2X7R (Suramin and A-438079) caused strong inhibition of production of Th17-promoting cytokines (IL-1β, TGF-β1, IL-23p19 and IL-6)...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774424/anti-arthritic-activity-of-a-classical-ayurvedic-formulation-vatari-guggulu-in-rats
#20
Madhavi G Patel, Kilambi Pundarikakshudu
In India, Vatari Guggulu has been traditionally used in the Ayurvedic system of medicine to treat rheumatoid arthritis (RA). The current study was undertaken to evaluate anti-arthritic activity of alcoholic extract of Vatari Guggulu in rats. Arthritis was induced by administration of formaldehyde (2%v/v) or Complete Freund's Adjuvant (CFA) into the sub-plantar surface of left hind paw of the animals. The extract was administered to the rats by oral gavages in different doses. Joint swelling was measured in formaldehyde induced arthritis...
October 2016: Journal of Traditional and Complementary Medicine
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