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https://www.readbyqxmd.com/read/27903576/first-reported-case-of-peroneal-tenosynovitis-caused-by-coccidioides-immitis-successfully-treated-with-fluconazole
#1
Aneela Majeed, Waqas Ullah, Auon Abbas Hamadani, Anca Georgescu
Coccidioidomycosis is an insidious infection caused by Coccidioides spp (C. immitis and C. posadasii). Disseminated disease occasionally involves tendon sheaths and synovium of the joints leading to tenosynovitis. Here, we describe the case of a 72-year-old woman from southern Arizona, who presented with right ankle pain, redness and swelling for 2 months. Her serum IgG was positive for C. immitis on complement fixation, and her MRI of the right ankle joint showed extensive tenosynovitis of the right peroneal tendons, and subtalar joint effusions with associated synovitis...
November 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27885357/achilles-tendinopathy-current-concepts-about-the-basic-science-and-clinical-treatments
#2
REVIEW
Hong-Yun Li, Ying-Hui Hua
Achilles tendinopathy is one of the most frequently ankle and foot overuse injuries, which is a clinical syndrome characterized by the combination of pain, swelling, and impaired performance. The two main categories of Achilles tendinopathy are classified according to anatomical location and broadly include insertional and noninsertional tendinopathy. The etiology of Achilles tendinopathy is multifactorial including both intrinsic and extrinsic factors. Failed healing response and degenerative changes were found in the tendon...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27851983/osteopontin-inhibition-of-mir-129-3p-enhances-il-17-expression-and-monocyte-migration-in-rheumatoid-arthritis
#3
Chun-Hao Tsai, Shan-Chi Liu, Yu-Han Wang, Chen-Ming Su, Chien-Chung Huang, Chin-Jung Hsu, Chih-Hsin Tang
BACKGROUND: Osteopontin (OPN) is an important proinflammatory cytokine in rheumatoid arthritis (RA). Levels of OPN have been shown to be significantly correlated with interleukin-17 (IL-17) production and expression of Th17 cells in the synovial fluid of RA patients. Here, we investigated the role of OPN in monocyte migration, IL-17 production and osteoblasts. METHODS: OPN and IL-17 expression profiles in osteoarthritis (OA) and RA synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA)...
November 13, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27826329/recurrent-macrophage-activation-syndrome-since-toddler-age-in-an-adolescent-boy-with-hla-b27-positive-juvenile-ankylosing-spondylitis
#4
Joon Hyeong Park, Yu Mi Seo, Seung Beom Han, Ki Hwan Kim, Jung Woo Rhim, Nack Gyun Chung, Myung Shin Kim, Jin Han Kang, Dae Chul Jeong
Recurrent macrophage activation syndrome (MAS) is very rare. We present the case of an adolescent boy with human leukocyte antigen (HLA) B27-positive ankylosing spondylitis (AS), who experienced episodes of recurrent MAS since he was a toddler. A 16-year-old boy was admitted because of remittent fever with pancytopenia and splenomegaly after surgical intervention for an intractable perianal abscess. He had been diagnosed with hemophagocytic lymphohistiocytosis (HLH) 4 different times, which was well controlled with intravenous immunoglobulin and steroids since the age of 3...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27802849/miliary-tuberculosis-and-acquired-immunodeficiency-syndrome-a-cursed-duet
#5
Atif Tatari, Sahana Ramanujam, Suja Mathai, Nigahus Karabulut, Robert L Moser, Sara L Wallach
Tuberculous osteomyelitis is rare and usually involves the vertebrae but is seldom found in the foot. The uncommon site and ability to mimic other disorders clinically and radiographically leads to diagnostic and therapeutic delays. We report a case of a 40-year-old man who initially presented to his podiatrist with intermittent pain and swelling of his right ankle and foot that lasted for a year. He also started to exhibit significant weight loss and unexplained fevers and was subsequently hospitalized for cellulitis of his right foot...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27776554/s100a8-a9-a-potent-serum-and-molecular-imaging-biomarker-for-synovial-inflammation-and-joint-destruction-in-seronegative-experimental-arthritis
#6
Edwin J W Geven, Martijn H J van den Bosch, Irene Di Ceglie, Giuliana Ascone, Shahla Abdollahi-Roodsaz, Annet W Sloetjes, Sven Hermann, Michael Schäfers, Fons A J van de Loo, Peter M van der Kraan, Marije I Koenders, Dirk Foell, Johannes Roth, Thomas Vogl, Peter L E M van Lent
BACKGROUND: Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthritides. In this study, we investigated the biomarker potential of systemic and local levels of these S100 proteins to assess joint inflammation and joint destruction in an experimental model for seronegative arthritis...
October 24, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27775097/involvement-of-p2x7-receptor-signaling-on-regulating-the-differentiation-of-th17-cells-and-type-ii-collagen-induced-arthritis-in-mice
#7
Zhi-Dan Fan, Ya-Yuan Zhang, Yi-Hong Guo, Na Huang, Hui-Hui Ma, Hui Huang, Hai-Guo Yu
Interleukin (IL)-17 producing T helper (Th17) cells are major effector cells in the pathogenesis of rheumatoid arthritis (RA). The P2X7 receptor (P2X7R) has emerged as a potential site in the regulation of inflammation in RA but little is known of its functional role on the differentiation of Th17 cells. This study investigates the in vitro and in vivo effects of P2X7R on Th17 cell differentiation during type II collagen (CII) induced experimental arthritis model. In CII-treated dendritic cells (DCs) and DC/CD4(+) T coculture system, pretreatment with pharmacological antagonists of P2X7R (Suramin and A-438079) caused strong inhibition of production of Th17-promoting cytokines (IL-1β, TGF-β1, IL-23p19 and IL-6)...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774424/anti-arthritic-activity-of-a-classical-ayurvedic-formulation-vatari-guggulu-in-rats
#8
Madhavi G Patel, Kilambi Pundarikakshudu
In India, Vatari Guggulu has been traditionally used in the Ayurvedic system of medicine to treat rheumatoid arthritis (RA). The current study was undertaken to evaluate anti-arthritic activity of alcoholic extract of Vatari Guggulu in rats. Arthritis was induced by administration of formaldehyde (2%v/v) or Complete Freund's Adjuvant (CFA) into the sub-plantar surface of left hind paw of the animals. The extract was administered to the rats by oral gavages in different doses. Joint swelling was measured in formaldehyde induced arthritis...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27771027/intra-articular-injection-with-triamcinolone-hexacetonide-in-patients-with-rheumatoid-arthritis-prospective-assessment-of-goniometry-and-joint-inflammation-parameters
#9
Rita Nely Vilar Furtado, Flávia Soares Machado, Karine Rodrigues da Luz, Marla Francisca Dos Santos, Monique Sayuri Konai, Roberta Vilela Lopes, Jamil Natour
OBJECTIVES: To evaluate local joint variables after intra-articular injection (IAI) with triamcinolone hexacetonide (HT) in rheumatoid arthritis (RA) patients. METHODS: We blindly and prospectively (baseline, 1, 4, 12 and 24 weeks) evaluated metacarpophalangeal (MCP), wrist, elbow, shoulder, knee and ankle joints after HT IAI by the following outcome measures: Visual analogue scale 0-10cm (VAS) for rest pain (VASR); VAS for movement pain (VASM); VAS for joint swelling (VASSw); flexion (FlexG) and extension (ExtG)...
August 18, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27757193/giant-cell-tumor-of-tendon-sheath-in-the-knee
#10
Malek Ghnaimat, Mohannad Alodat, Mohammad Aljazazi, Raad Al-Zaben, Jamal Alshwabkah
The giant cell tumor of the tendon sheath (GCTTS) is a benign lesion which arises from the synovium of a joint, bursa or tendon sheath, with 85% of the tumors occurring in the fingers and 12% of the tumors located in large joints such as the knee and ankle. The GCTTS is usually monoarticular, slowly proliferative and rarely locally aggressive. This paper reports three cases of this rare lesion in the knee. Patients presented with painful swelling in the anterior knee, MRI showed localized soft tissue masses which were able to be excised...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27756859/a-specifically-designed-aquatic-exercise-protocol-to-reduce-chronic-lower-limb-edema
#11
Sergio Gianesini, Mirko Tessari, Primo Bacciglieri, Anna Maria Malagoni, Erica Menegatti, Savino Occhionorelli, Nino Basaglia, Paolo Zamboni
OBJECTIVE: Despite the fact that muscle pump activation is known to positively impact chronic lower limb edema, objective measurements of standardized exercises for venous-lymphatic rehab are lacking. The aim of this investigation is to determine the effectiveness of an addressed physical activity exploiting the advantages of an aquatic environment. MATERIAL AND METHODS: Thirty-two lower limbs of 16 patients affected by bilateral chronic leg swelling were included (12 females, 4 males)...
October 18, 2016: Phlebology
https://www.readbyqxmd.com/read/27703931/retrocalcaneal-bursitis-due-to-rare-calcaneal-osteochondroma-in-adult-male-excision-and-outcome
#12
Rupesh Kumar, Anjana, Meghraj Kundan
INTRODUCTION: Osteochondroma is the most common benign tumour of the bone and is considered as developmental lesion of the bone. Common site of osteochondroma presentation is around the knee but calcaneal osteochondroma as such is a rare entity. Osteochondromas grow during childhood through adolescence, but usually the growth of osteochondroma ends when the epiphyseal plates close. In an adult, growth of an osteochondroma suggests the diagnosis of a malignant transformation. However, it can also present as pressure symptom in later phase of life...
April 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27668102/a-unique-case-of-mycophenolate-induced-colitis-after-10-years-of-use
#13
Abhinav Goyal, Moiz Salahuddin, Yogesh Govil
A 31-year-old female with a history of lupus nephritis on Hydroxychloroquine, Prednisone, and Mycophenolate Mofetil (MMF) for 10 years presented to the hospital for ankle swelling. On day four, she started to have severe, nonbloody, watery diarrhea with abdominal distension and tenderness. Stool PCR was negative for C. difficile. CT abdomen/pelvis showed gaseous distension of the colon without any obstruction. Flexible sigmoidoscopy revealed a normal looking mucosa. Histopathology showed crypt atrophy and increased crypt apoptosis, consistent with MMF colitis...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27659849/factors-associated-with-pain-intensity-and-physical-limitations-after-lateral-ankle-sprains
#14
Jan Paul Briet, Roderick M Houwert, Michiel G J S Hageman, Falco Hietbrink, David C Ring, Egbert Jan J M Verleisdonk
BACKGROUND: Swelling, tenderness, and ecchymosis don't correlate with time to functional recovery in patients with a lateral ankle sprain. It is established that psychosocial factors such as symptoms of depression and low pain self-efficacy correlate with pain intensity and magnitude of limitations in patients with musculoskeletal disorders. OBJECTIVE: We studied the correlation between pain self-efficacy or symptoms of depression and (1) ankle specific limitations and (2) pain intensity in patients with a lateral ankle sprain...
September 9, 2016: Injury
https://www.readbyqxmd.com/read/27639000/venous-leg-symptoms-in-healthy-subjects-assessed-during-prolonged-standing
#15
Werner Blättler, Hans-Jürgen Thomae, Felix Amsler
OBJECTIVE: The core symptoms of venous disease include leg discomfort or pain accompanied by sensations of heavy, weighty, or swollen legs. This suggests the presence of a cause and effect relationship between swelling and pain, resulting in the assumption that a venous disorder is responsible. The aim of this study was to investigate the relationship between leg volume increase and symptoms provoked by a period of stationary standing and also to investigate the effect of medical compression stockings (MCS)...
October 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27616030/inhibitory-effects-of-saussurea-involucrata-kar-et-kir-sch-bip-on-adjuvant-arthritis-in-rats
#16
Xiaoli Han, Dan Su, Xiaoyan Xian, Mingyang Zhou, Xianzhe Li, Jian Huang, Jinhui Wang, Huiyuan Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Saussurea involucrate (Kar. et Kir.) Sch. -Bip is an endangered species of the Compositae family, and this species has long been used for the treatment of rheumatoid arthritis, dysmenorrhea, stomachache, and altitude sickness in Uighur folk and Chinese medicine. AIM OF THE STUDY: This study aimed to investigate the different therapeutic efficacy of alcohol infusion (SEI) and water decoction (SWD) of S. involucrata in treating rheumatoid arthritis using complete Freund's adjuvant (CFA)-induced arthritis (AA) in a rat model...
September 8, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27587374/bone-marrow-edema-syndrome-in-the-foot-and-ankle
#17
REVIEW
Seyed Alireza Mirghasemi, Elly Trepman, Mohammad Saleh Sadeghi, Narges Rahimi, Shervin Rashidinia
: Bone marrow edema syndrome (BMES) is an uncommon and self-limited syndrome characterized by extremity pain of unknown etiology. Symptoms may include sudden or gradual onset of swelling and pain at rest or during activity, usually at night. This syndrome mostly affects middle-aged men and younger women who have pain in the lower extremities. The most common sites involved with BMES, in decreasing order of frequency, are the bones about the hip, knee, ankle, and foot. The diagnosis of BMES is confirmed with magnetic resonance imaging to exclude other causes of bone marrow edema...
December 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27584788/kinsenoside-screening-with-a-microfluidic-chip-attenuates-gouty-arthritis-through-inactivating-nf-%C3%AE%C2%BAb-signaling-in-macrophages-and-protecting-endothelial-cells
#18
Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-He, Zheng Yu-Hua, Han Xiu-Guo, Wang Yu-Gang, Fan Qi-Ming, Yang Shih-Mo, Tang Ting-Ting
Gouty arthritis is a rheumatic disease that is characterized by the deposition of monosodium urate (MSU) in synovial joints cause by the increased serum hyperuricemia. This study used a three-dimensional (3D) flowing microfluidic chip to screen the effective candidate against MSU-stimulated human umbilical vein endothelial cell (HUVEC) damage, and found kinsenoside (Kin) to be the leading active component of Anoectochilus roxburghi, one of the Chinese medicinal plant widely used in the treatment of gouty arthritis clinically...
2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27579205/gluteal-compartment-syndrome-secondary-to-pelvic-trauma
#19
Fernando Diaz Dilernia, Ezequiel E Zaidenberg, Sebastian Gamsie, Danilo E R Taype Zamboni, Guido S Carabelli, Jorge D Barla, Carlos F Sancineto
Gluteal compartment syndrome (GCS) is extremely rare when compared to compartment syndrome in other anatomical regions, such as the forearm or the lower leg. It usually occurs in drug users following prolonged immobilization due to loss of consciousness. Another possible cause is trauma, which is rare and has only few reports in the literature. Physical examination may show tense and swollen buttocks and severe pain caused by passive range of motion. We present the case of a 70-year-old man who developed GCS after prolonged anterior-posterior pelvis compression...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27574922/effect-of-electroacupuncture-in-zusanli-and-kunlun-acupoints-on-tlr4-signaling-pathway-of-adjuvant-arthritis-rats
#20
Zhe-Qing Dong, Ji Zhu, De-Zhao Lu, Qin Chen, Ying-Ling Xu
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Previous study suggested that toll-like receptor (TLR) signaling pathway contributes to the development and progression of RA. In recent years, acupuncture has become one of the most vital treatments of arthralgia. But little is known about the mechanisms of improving RA by acupuncture. STUDY QUESTION: The study studied the effect of electroacupuncture in "Zusanli" and "Kunlun" acupoints on the expression of TLR4, myeloid differentiation factor 88 (MYD88), and NF-κB in adjuvant arthritis rats to clarify the molecular mechanism of acupuncture of RA...
August 29, 2016: American Journal of Therapeutics
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