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https://www.readbyqxmd.com/read/29753098/anti-arthritic-activities-of-ethanol-extracts-of-circaea-mollis-siebold-zucc-whole-plant-in-rodents
#1
Yanhong Yu, Qing Zhang, Jiajia Li, Yeli Guan, Jiangeng Huang, Zhiping Wang, Zhen Zhang, Wenrui Zhang, Jing Guo, Jinghua Li, Jiachun Chen, Qun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Circaea mollis Siebold & Zucc., a genus of Circaea that follows Onagraceae, has been used for centuries as a folk herb in traditional Chinese medicine (TCM) and Hani Ethnopharmacy for the treatment of joint swelling and pain in rheumatoid arthritis. AIM OF THE STUDY: This study was designed to confirm anti-arthritic effects and its underlying mechanism of ethanol extracts of Circaea mollis Siebold & Zucc. (EEC), which may contribute to provide the pharmacological basis in the treatment of rheumatoid disease...
May 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29742720/sacral-epiduroscopic-laser-decompression-for-complex-regional-pain-syndrome-after-lumbar-spinal-surgery-a-case-report
#2
Jae-Wook Jung, Yong Han Kim, Hyojoong Kim, Eunsu Kang, Hyunji Jo, Myoung Jin Ko
RATIONALE: CRPS after a lumbar surgery has symptoms that are similar to PSSS. However, standard criteria for distinguishing CRPS from PSSS do not exist. We present a case report of a 31-year-old female with CRPS symptoms after lumbar spinal surgery treated by performing SELD. PATIENT CONCERNS: This patient was referred to our pain clinic for left ankle pain. She received a lumbar discectomy for a herniated lumbar disc (L5/S1) but the pain was aggravated after surgery...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29737592/cytological-diagnosis-of-cerebrotendinous-xanthomatosis-in-two-siblings-presenting-with-bilateral-ankle-swellings-and-neurological-decline
#3
Aruna Nambirajan, G S Anju, Ajay Garg, Deepa Dash, Rohit Bhatia, Mehar Chand Sharma, Sandeep R Mathur
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive metabolic disease caused by inactivating mutations in the CYP27A1 gene, encoding for sterol 21-hydroxylase, a mitochondrial enzyme, involved in bile acid synthesis. First reported by Bogaert in 1937, hundreds of cases have been described since,1 with an estimated prevalence of <5 per one million people worldwide. The enzyme deficiency leads to decreased bile acid synthesis with resultant excess production and tissue accumulation of cholestanol...
May 8, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29713784/limited-evidence-for-adipose-derived-stem-cell-therapy-on-the-treatment-of-osteoarthritis
#4
REVIEW
Eoghan T Hurley, Youichi Yasui, Arianna L Gianakos, Dexter Seow, Yoshiharu Shimozono, Gino M M J Kerkhoffs, John G Kennedy
PURPOSE: The purpose of this systematic review is to evaluate the effects of adipose derived mesenchymal stem cells (ADSCs) in the treatment of osteoarthritis (OA) in the clinical setting. METHODS: A literature search was performed in the MEDLINE, EMBASE, and The Cochrane Library Database up to January 2017 for inclusion and exclusion criteria. Criteria for inclusion were clinical studies demonstrating the effects of ADSCs on OA, and written in English. The following variables were analyzed: donor site, volume of adipose tissue, preparation of ADSCs, clinical outcomes, and complication rate...
April 30, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29683839/obesity-impacts-swelling-of-ankle-and-foot-joints-in-early-rheumatoid-arthritis-patients
#5
Veena K Ranganath, Erin L Duffy, Vikram K Garg, Thasia Woodworth, Mihaela Taylor, Harold E Paulus, Roy D Altman, David A Elashoff
OBJECTIVE: The evaluation of disease activity in obese rheumatoid arthritis (RA) patients presents challenges particularly in the clinical assessment of swollen joints. This study examines the effect of obesity on the American College of Rheumatology (ACR) core set measures used in assessing RA disease activity with specific focus on the swollen joint count (SJC). METHODS: We examined a cross-sectional cohort of 323 early seropositive RA patients (symptom duration ≤15 months)...
April 16, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29681086/a-novel-homozygous-mutation-in-the-slco2a1-gene-causing-pachydermoperiostosis-efficacy-of-hydroxychloroquine-treatment
#6
Annalisa Alessandrella, Roberto Della Casa, Maria Alessio, Jorge Puente Prieto, Pietro Strisciuglio, Daniela Melis
Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation. Joint pain, polyarthritis, cutis verticis gyrata, seborrhea, and hyperhidrosis are frequently associated to this condition. We report a 17-year-old boy presented with pain and swelling of knees and ankles, and progressive thickening of skin face with seborrhea from about 4 years. At the admission he also showed digital clubbing of both hands and feet and palmoplantar hyperhidrosis...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29679725/achyranthis-bidentatae-radix-enhanced-articular-distribution-and-anti-inflammatory-effect-of-berberine-in-sanmiao-wan-using-an-acute-gouty-arthritis-rat-model
#7
Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29669300/gzmb-gene-silencing-confers-protection-against-synovial-tissue-hyperplasia-and-articular-cartilage-tissue-injury-in-rheumatoid-arthritis-through-the-mapk-signaling-pathway
#8
Cui-Xia Bao, Hai-Xia Chen, Xue-Jie Mou, Xiang-Kui Zhu, Qi Zhao, Xin-Guang Wang
INTRODUCTION: Rheumatoid arthritis (RA) represents the most commonly occurring inflammatory type of arthritis and is a major cause of disability. Reports have placed emphasis on the potential of, granzyme B (GZMB) as a potentially valuable prognostic marker in early RA, the mechanism of which still remains largely unclear. Thus, the aim of the current study was to investigate the effects GZMB gene silencing influences synovial tissue hyperplasia and articular cartilage tissue injury of RA through the regulation of the MAPK signaling pathway...
April 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29669173/second-generation-syk-inhibitor-entospletinib-ameliorates-fully-established-inflammation-and-bone-destruction-in-the-cherubism-mouse-model
#9
Tetsuya Yoshimoto, Tatsuhide Hayashi, Toshio Kondo, Mizuho Kittaka, Ernst J Reichenberger, Yasuyoshi Ueki
Cherubism is a craniofacial disorder characterized by maxillary and mandibular bone destruction. Gain-of-function mutations in the SH3-domain binding protein 2 (SH3BP2) are responsible for the excessive bone resorption caused by fibrous inflammatory lesions. A homozygous knock-in (KI) mouse model for cherubism (Sh3bp2KI/KI ) develops autoinflammation resulting in systemic bone destruction. While administration of the TNF-α blocker etanercept to neonatal Sh3bp2KI/KI mice prevented the disease onset, this therapy was not effective for adult Sh3bp2KI/KI mice or human cherubism patients who already had lesions...
April 18, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29657213/reactive-perforating-collagenosis-an-important-differential-diagnosis-in-hemodialysis-patients
#10
Ayan Kumar Dey
This is a case report of a 68-year-old hypertensive, diabetic woman who was on regular thrice weekly hemodialysis (HD). She presented with gradually worsening left lower limb pain and swelling. Clinical examination revealed significant edema over the left calf and ankle joint with significant calf tenderness. Extensive workup including magnetic resonance imaging of the lower limb and venous Doppler failed to show any significant abnormality. In view of developing papular lesions over the area, skin biopsy was performed, which finally confirmed reactive perforating collagenosis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29655702/4-2-4-chlorophenyl-1-4-chlorophenyl-amino-ethyl-benzene-1-3-diol-is-a-potential-agent-for-gout-therapy-as-a-dual-inhibitor-of-xod-and-nlrp3
#11
Mengze Zhou, Suning Li, Ling Song, Qinghua Hu, Wentao Liu
BACKGOUND: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient. PURPOSE: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29628811/isolated-stieda-process-fracture-of-talus-a-case-study
#12
William L Moore, Beverly L Harger
Objective: The purpose of this case report is to describe a patient with a fracture of the Stieda process. Clinical Features: A 39-year-old woman presented with pain and swelling of her left ankle immediately following a boogie boarding accident a few days earlier. Her clinical presentation was similar to that of an ankle sprain. Intervention and Outcome: Radiographs were ordered, and a fracture of a normal variant, the Stieda process, was identified...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29609267/-effects-of-sural-nerve-nutrition-vess-els-supported-flap-for-reconstruction-of-distal-lower-leg-and-ankle-soft-tissue-defects
#13
D Ding, F Zhao, Y L Huang, X L Li, F Gong, Z C Yao, B W Zhang, Z Y Yang, J M Ma, J Shen, P Wen
Objective: To observe the effects of sural nerve nutrition vessels-supported flap for reconstruction of distal lower leg and ankle soft tissue defects. Methods: From June 2014 to June 2017, 37 patients with calf distal and ankle soft tissue defect were repaired with sural nerve nutrition vessels-supported flap, of them 12 cases with calf distal soft tissue defect wounds and 25 cases with ankle soft tissue defect wounds.The scope of flaps was 9 cm×4 cm to 18 cm×9 cm, anti-infection, anti-freezing and dressing treatments were carried out after operation...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29608114/prolonged-toxicity-from-kambo-cleansing-ritual
#14
Kai Li, Howard Horng, Kara Lynch, Craig G Smollin
CONTEXT: Kambo cleanse is a purification, cleansing ritual traditionally performed by South American shaman to confer luck and health to hunters. CASE DETAILS: We report a patient who presented to the emergency department with prolonged symptoms of vomiting, flushing, facial swelling, altered mental status, and agitation requiring chemical restraints, 22 h after a Kambo cleanse. The patient was found with four small, circular, superficial burns to the ankle at the site where the resin was introduced...
April 2, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29599513/akkermansia-muciniphila-is-permissive-to-arthritis-in-the-k-bxn-mouse-model-of-arthritis
#15
Matthew L Stoll, M Kathy Pierce, Jordan A Watkins, Mingce Zhang, Pamela F Weiss, Jennifer E Weiss, Charles O Elson, Randy Q Cron, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb
Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in those that received patient vs. control microbiota. Principal coordinates analysis revealed incomplete uptake of the human microbiota with over-representation of two genera (Bacteroides and Akkermansia) among the transplanted mice...
March 24, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29587801/effects-of-dangguixu-san-on-acute-lateral-ankle-sprain-study-protocol-for-a-randomized-controlled-trial
#16
Jae-Hong Kim, Eun-Yong Lee, Myung-Rae Cho, Cham-Kyul Lee, Ji-Hyun Cho
BACKGROUND: Ankle sprain is a common musculoskeletal injury. In Korean medicine, blood stasis is thought to be the main cause of pain and swelling in patients with ankle sprain. Dangguixu-san (DS), a herbal extract, is widely used in Korean medicine for the treatment of traumatic ecchymosis and pain by promoting blood circulation and relieving blood stasis. However, the effects of DS on ankle sprain have not been evaluated in a randomized clinical trial. Here, we describe the protocol for a randomized controlled trial that will evaluate the efficacy and safety of DS for the treatment of ankle sprain...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29567573/-1-h-nmr-based-metabolomics-approach-to-investigate-the-urine-samples-of-collagen-induced-arthritis-rats-and-the-intervention-of-tetrandrine
#17
Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia
Tetrandrine is an effective ingredient isolated from the roots of a frequently used medicinal plant Stephania tetrandra S. Moore. It has been used for the management of arthritis in China, but the precise mechanism remains unclear. In the present study, a metabolomics method based on the1 H NMR was constituted to quantify the alterations of the endogenous metabolites in the urines of collagen-induced arthritis (CIA) rats treated with tetrandrine. Data showed that tetrandrine treatment could alleviate the ankle joint swelling and ameliorate histopathological changes in rats...
March 14, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29544526/mice-with-mir-146a-deficiency-develop-severe-gouty-arthritis-via-dysregulation-of-traf-6-irak-1-and-nalp3-inflammasome
#18
Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-Shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou
BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. However, the role of miR-146a in the development of gout remains unknown. Here, we used miR-146a knockout (KO) mice to test miR-146a function in a monosodium urate (MSU)-induced gouty arthritis model...
March 15, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29540097/crocin-exerts-anti-inflammatory-and-anti-arthritic-effects-on-type-ii-collagen-induced-arthritis-in-rats
#19
Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu, Ying Wen
CONTEXT: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. OBJECTIVE: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. MATERIALS AND METHODS: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29523956/a-novel-method-of-using-elastic-bionic-fixation-device-for-distal-tibiofibular-syndesmosis-injury
#20
Lin Wang, Yingze Zhang, Zhaohui Song, Hengrui Chang, Ye Tian, Fei Zhang
PURPOSE: To describe and evaluate the novel method of using elastic bionic fixation device in treating the distal tibiofibular syndesmosis (DTS) injury. METHODS: From June 2013 to January 2014, 17 subjects with ankle fractures combined with DTS separation were treated by the elastic bionic fixation device. The syndesmotic parameters, healing, functional scores, and possible complications were recorded. RESULTS: All patients had a mean follow-up of 23...
March 9, 2018: International Orthopaedics
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