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Ankle swelling

Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-Shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou
BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. However, the role of miR-146a in the development of gout remains unknown. Here, we used miR-146a knockout (KO) mice to test miR-146a function in a monosodium urate (MSU)-induced gouty arthritis model...
March 15, 2018: Arthritis Research & Therapy
Wei Liu, Yufeng Sun, Zhenping Cheng, Yong Guo, Peiming Liu, Ying Wen
CONTEXT: Rheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models. OBJECTIVE: This study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. MATERIALS AND METHODS: The CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days...
December 2018: Pharmaceutical Biology
Lin Wang, Yingze Zhang, Zhaohui Song, Hengrui Chang, Ye Tian, Fei Zhang
PURPOSE: To describe and evaluate the novel method of using elastic bionic fixation device in treating the distal tibiofibular syndesmosis (DTS) injury. METHODS: From June 2013 to January 2014, 17 subjects with ankle fractures combined with DTS separation were treated by the elastic bionic fixation device. The syndesmotic parameters, healing, functional scores, and possible complications were recorded. RESULTS: All patients had a mean follow-up of 23...
March 9, 2018: International Orthopaedics
Gisela Eugénio, João Tavares, Mary Marques, Cátia Duarte, J A P da Silva
No abstract text is available yet for this article.
March 9, 2018: BMJ: British Medical Journal
Gwendolyn Vuurberg, Alexander Hoorntje, Lauren M Wink, Brent F W van der Doelen, Michel P van den Bekerom, Rienk Dekker, C Niek van Dijk, Rover Krips, Masja C M Loogman, Milan L Ridderikhof, Frank F Smithuis, Sjoerd A S Stufkens, Evert A L M Verhagen, Rob A de Bie, Gino M M J Kerkhoffs
This guideline aimed to advance current understandings regarding the diagnosis, prevention and therapeutic interventions for ankle sprains by updating the existing guideline and incorporate new research. A secondary objective was to provide an update related to the cost-effectiveness of diagnostic procedures, therapeutic interventions and prevention strategies. It was posited that subsequent interaction of clinicians with this guideline could help reduce health impairments and patient burden associated with this prevalent musculoskeletal injury...
March 7, 2018: British Journal of Sports Medicine
Kotaro Matsumoto, Jun Kikuchi, Yuko Kaneko, Hidekata Yasuoka, Kazuko Suzuki, Hirobumi Tokuyama, Kaori Kameyama, Kunihiro Yamaoka, Tsutomu Takeuchi
RATIONALE: Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes. PATIENT CONCERNS: A 64-year-old man on hemodialysis for >30 years was admitted because of intermittent fever, polyarthritis, and elevated serum C-reactive protein (CRP) level, which was continuous for 2 years...
January 2018: Medicine (Baltimore)
Volkan Gurkan, Ozgur Erdogan
Foot and ankle osteoid osteomas (OOs) are often cancellous or subperiosteal and rarely present with a periosteal reaction. Additionally, the large number of disorders included in the differential diagnosis and the nonspecific findings on radiographs complicate the diagnosis. We performed a manual search of the senior surgeon's hospitals' operating room records for the terms "benign bone tumor," "foot," "ankle," and "osteoid osteoma" from January 2003 until December 2014...
March 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Chao Wang, Jia-Lian Li, Hong-Kui Wei, Yuan-Fei Zhou, Jia-Jian Tan, Hai-Qing Sun, Si-Wen Jiang, Jian Peng
This study aimed to investigate the factors affecting boar claw lesions and lameness. A total of 1299 boars were examined for claw lesions and lameness, including 788 boars reared in individual pens with solid concreted floor (IPS) and 511 boars raised in individual stalls with slatted floor (ISS). Flooring type showed significant impacts on all claw lesion types (P < 0.01). Except for swelling ankle, boar age had significant effects on all other claw lesion types (P < 0.01). In addition, only heel overgrowth and erosion, cracked wall horizontal, heel-sole crack, dew claws, and toes were significantly related to boar breeds (P < 0...
February 6, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
Hamdi Wafa, Miladi Saoussen, Kaffel Dhia, Zouch Imen, Kchir Mohamed Montacer
Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Case Presentation: A 48-years-old woman presented with inflammatory back pain for 5 years and ankle swelling for 1 year. On physical examination, she had an exaggerated dorsal kyphosis and disappearance of lumbar lordosis with limitation in motion of the cervical and lumbar spine...
2018: Caspian Journal of Internal Medicine
Stavros Kakkos, Andrew Nicolaides
INTRODUCTION: The use of a venoactive drug is considered an important component of medical treatment of chronic venous disease (CVD), although the efficacy of certain VADs on one or more individual leg symptoms or signs may have not been extensively studied to justify a strong recommendation in guidelines on CVD. The aim of this systematic review and metaanalysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, Daflon®) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
Hengyan Zhang, Bo Yang
RATIONALE: Pachydermoperiostosis (PDP) is a rare hereditary disorder that affects the skin and bones. PDP is characterized by periostosis, digital clubbing, and pachydermia. Previous studies demonstrated that increased prostaglandin E2 (PGE2) levels resulting from defective protein degradation pathways play a crucial role in PDP pathogenesis, and males were more commonly and severely affected than females. Moreover, nearly all PDP patients suffer from refractory arthralgia. Although several different treatment modalities are used for PDP, therapy for this disease remains challenging...
November 2017: Medicine (Baltimore)
Komal Rao, Sabahat Aziz, Talat Roome, Anam Razzak, Bushra Sikandar, Khawar Saeed Jamali, Muhammad Imran, Tooba Jabri, Muhammad Raza Shah
Nanomedicines anticipate drug delivery to inflamed tissues in rheumatoid arthritis (RA) with greater efficacy and lesser side effects. This study investigates the anti-arthritic potentials of Hesperidin (HP) loaded in gum acacia (GA) stabilized green silver nanoparticles (AgNPs). Synthesized GA-AgNPs were characterized through UV-vis spectrophotometer, zetasizer and atomic force microscope (AFM). The HP and its loaded NPs were tested for RA in Complete Freund's adjuvant (CFA) induced arthritis model. GA-AgNPs were found in nano-range size with negative charge, spherical shape and loaded increased HP amount...
January 30, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Alan J Wright, Zoé M A Husson, De-En Hu, Gerard Callejo, Kevin M Brindle, Ewan St John Smith
Arthritic conditions are a major source of chronic pain. Furthering our understanding of disease mechanisms creates the opportunity to develop more targeted therapeutics. In rheumatoid arthritis (RA), measurements of pH in human synovial fluid suggest that acidosis occurs, but that this is highly variable between individuals. Here we sought to determine if tissue acidosis occurs in a widely used rodent arthritis model: complete Freund's adjuvant (CFA)-induced inflammation. CFA robustly evoked paw and ankle swelling, concomitant with worsening clinical scores over time...
January 30, 2018: NMR in Biomedicine
Zhidan Liu, Xiaoyan Li, Chuang Zhao, Chunlan Chen, Miao Li, Qian Tan, Ling Zhang, Wei Liang
OBJECTIVE: To observe the effects of moxibustion on Treg/Th17 imbalance and related signal pathway in mice with rheumatoid arthritis (RA), so as to explore the action mechanism of moxibustion on RA. METHODS: Twenty-four DBA/1J male mice were randomly divided into a normal group, a model group, a sham moxibustion group and a moxibustion group, 6 mice in each one. RA model was induced by subcutaneous injection of typeⅡcollagen and adjuvant at tail in mice other than the normal group...
October 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Hyeng Il Cheun, Hee Eun Shin, Da Won Ma, Sung Hee Hong, Tae Yun Kim, Sang Eun Lee, JungWon Ju, Yun-Kyu Park, Tong-Soo Kim, Shin Hyeong Cho
Objectives: Korea was an endemic area for lymphatic filariasis (LF), caused by the nematode parasite Brugia malayi, until the 1970s. The World Health Organization recognized Korea as LF-free in June 2008. However, it is necessary to confirm that patients that have had LF in the past still test negative, to prevent the re-emergence of LF in Korea. Methods: We followed up a total of 83 patients who had been diagnosed with LF between 2002 and 2010 in endemic LF areas...
December 2017: Osong Public Health and Research Perspectives
Mas'uud Ibnu Samsudin, Ming Quan Wayne Yap, Ang Wei Luong, Ernest Beng Kee Kwek
BACKGROUND: Tightrope fixation is an emerging technique for syndesmotic fixation with promising results. However, our case series highlights the slippage of Tightrope buttons as a complication of suture button syndesmotic fixation of Weber C malleolar fractures using limited contact dynamic compression (LCDCP) plates. METHODS: We report a series of cases from our database in which slippage of the Tightrope button through the LCDCP holes in Weber C malleolar fractures was noted...
January 1, 2018: Foot & Ankle International
Li Cai, Wei-Na Chen, Rong Li, Cheng-Mu Hu, Chao Lei, Chun-Mei Li
OBJECTIVES: Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients and that AQP1 may be involved in joint swelling and synovial inflammation. This study was aimed to investigate the potential therapeutic effect of acetazolamide (AZ, an AQP1 inhibitor) on rat adjuvant-induced arthritis (AIA) and explore its related mechanisms. MATERIALS AND METHODS: Rat AIA was induced by complete Freund's adjuvant...
January 5, 2018: Immunopharmacology and Immunotoxicology
Cailbhe Doherty, Chris Bleakley, Jay Hertel, Brian Caulfield, John Ryan, Eamonn Delahunt
OBJECTIVE: To evaluate whether a battery of clinical assessments for acute lateral ankle sprain (LAS) can be used to predict long-term recovery. DESIGN: Cohort study SETTING: University biomechanics laboratory PARTICIPANTS: Eighty-two individuals were assessed using a clinical test battery within two-weeks of incurring a first-time LAS. MAIN OUTCOME MEASURES: The clinical test battery included scores on the 'talar-glide' (deg), anterior-drawer, talar-tilt, figure-of-eight [figure8] for swelling (mm), knee-to-wall (mm) and hand-held goniometric range-of-motion [inversion; eversion; plantar-flexion (in degrees)]...
December 20, 2017: Archives of Physical Medicine and Rehabilitation
Biswajit Dey, Archana Hemant Deshpande, Pushpanjali Ojha, Chitrawati Bal Gargade, Jitendra Singh Nigam, Amit Ray
No abstract text is available yet for this article.
2017: CytoJournal
Bradley M Kruckeberg, Taylor J Ridley, Lee M Reichel
CASE: A 67-year-old woman underwent internal fixation of an ankle fracture. Ten days postoperatively, the patient developed systemic hives, difficulty breathing, and oral swelling. At 8 weeks postoperatively, the hardware was removed because of a suspected metal hypersensitivity. Despite experiencing perioral edema and difficulty breathing after the hardware removal, she had complete resolution of the symptoms at the 2-week, 6-week, and 12-month follow-up appointments. CONCLUSION: Hypersensitivities to metal-based implants can develop and cause local and systemic reactions...
April 2017: JBJS Case Connector
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