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https://www.readbyqxmd.com/read/27885357/achilles-tendinopathy-current-concepts-about-the-basic-science-and-clinical-treatments
#1
REVIEW
Hong-Yun Li, Ying-Hui Hua
Achilles tendinopathy is one of the most frequently ankle and foot overuse injuries, which is a clinical syndrome characterized by the combination of pain, swelling, and impaired performance. The two main categories of Achilles tendinopathy are classified according to anatomical location and broadly include insertional and noninsertional tendinopathy. The etiology of Achilles tendinopathy is multifactorial including both intrinsic and extrinsic factors. Failed healing response and degenerative changes were found in the tendon...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27855638/alteration-of-histone-h3k4-methylation-in-glomerular-podocytes-associated-with-proteinuria-in-patients-with-membranous-nephropathy
#2
Takayuki Fujino, Naoyuki Hasebe
BACKGROUND: Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of membranous nephropathy (MN), the most prevalent cause of primary nephrotic syndrome in the middle-aged and elderly, is podocyte dysfunction. METHODS: We investigated the role of H3K4 me3 in podocyte dysfunction in nephrotic syndrome using cultured podocytes and a mouse proteinuria model induced by LPS...
November 17, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27847022/an-exceptional-location-of-tuberculous-arthritis-the-metatarsal-phalangeal-joint
#3
Mohamed Ali Sbai, Sofien Benzarti, Wafa Gharbi, Wadia Khoffi, Riadh Maalla, Adel Khorbi
Osteoarticular tuberculosis is a rare type of tuberculosis. The spine is the most frequent location, while peripheral locations in the limbs are rare. We report a case of tuberculous osteoarthritis of the metatarsophalangeal joint of the first ray of the foot in a 48-year-old woman. The patient presented with painful swelling of the dorsum of the big toe, insidiously evolving for 6months. Diagnosis was obtained with histological study after surgical biopsy. Antitubercular chemotherapy for 12months promoted healing...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27807290/examining-the-potential-use-of-a-novel-radiographic-scoring-system-for-determining-surgical-intervention-in-diabetic-charcot-arthropathy
#4
Rahul Bijlani, Laurie M Lomasney, Michael Pinzur, Katherine Dux
: Introduction Although Eichenholtz and the Schon systems are commonly used to evaluate foot Charcot arthropathy on radiographs, a novel system with expanded characterization may have added benefit. Methods Patients with Charcot arthropathy and foot radiographs were grouped in nonsurgical group 1 (imaging sets at minimum 2-year interval) and surgical group 2 (imaging preceding fusion and/or amputation). Radiographs were scored with Eichenholtz and Schon systems, and a novel scoring system (summation of 0-3 rank for bone density, distention/swelling, debris, disorganization, and dislocation/subluxation)...
November 1, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27802849/miliary-tuberculosis-and-acquired-immunodeficiency-syndrome-a-cursed-duet
#5
Atif Tatari, Sahana Ramanujam, Suja Mathai, Nigahus Karabulut, Robert L Moser, Sara L Wallach
Tuberculous osteomyelitis is rare and usually involves the vertebrae but is seldom found in the foot. The uncommon site and ability to mimic other disorders clinically and radiographically leads to diagnostic and therapeutic delays. We report a case of a 40-year-old man who initially presented to his podiatrist with intermittent pain and swelling of his right ankle and foot that lasted for a year. He also started to exhibit significant weight loss and unexplained fevers and was subsequently hospitalized for cellulitis of his right foot...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27765025/staphylococcus-aureus-bacteremia-with-iliac-artery-endarteritis-in-a-patient-receiving-ustekinumab
#6
Insa Joost, Johannes Steinfurt, Philipp T Meyer, Winfried V Kern, Siegbert Rieg
BACKGROUND: Ustekinumab (Stelara®), a human monoclonal antibody targeting the p40-subunit of interleukin (IL)-12 and IL-23, is indicated for moderate to severe plaque psoriasis and psoriatic arthritis. In large multicenter, prospective trials assessing efficacy and safety of ustekinumab increased rates of severe infections have not been observed so far. CASE PRESENTATION: Here, we report the case of a 64-year old woman presenting with chills, pain and swelling of her right foot with dark maculae at the sole, and elevated inflammatory markers...
October 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27759355/spondyloepihyseal-dysplasia-congenita
#7
Renu Saigal, Alok Chaudhary, Prashant Pathak, Amandeep Singh, Deepak Gupta, M L Tank, Saahil Nohria, Diwanshu Khatana
We describe a case of Spondyloepiphyseal Dysplasia Congenita (SEDc) who presented to our rheumatology clinic with complaints of painful swelling of bilateral elbow, knee, distal and proximal interphalangeal joints (DIP and PIP) of hands and small joints of foot. Patient also complained of restriction during extension of bilateral wrist joint and lateral rotation of neck on both sides. He was also unable to walk without support.
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27743778/extract-from-eucommia-ulmoides-oliv-ameliorates-arthritis-via-regulation-of-inflammation-synoviocyte-proliferation-and-osteoclastogenesis-in-vitro-and-in-vivo
#8
Jian-Ying Wang, Ying Yuan, Xiao-Jun Chen, Sheng-Guang Fu, Lei Zhang, Yan-Long Hong, Sheng-Fu You, Yong-Qing Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Eucommia Ulmoides Oliv., a valuable Chinese herb, has shown a variety of health benefits. Despite the widespread clinical use of this herb to treat rheumatoid arthritis (RA) in Traditional Chinese Medicine (TCM), very few studies have described its anti-pathological effects or mechanism in RA. The present study investigated the mechanism of Eucommia Ulmoides Oliv. in an experimental collagen-induced arthritis (CIA) rat model. MATERIALS AND METHODS: The effects of four different Eucommia Ulmoides Oliv...
October 12, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27720630/an-unusual-case-of-pigmented-villo-nodular-synovitis-of-the-second-toe-a-case-report-and-review-of-literature
#9
Pankaj Sharma, Vivek Tiwari, Shah Alam Khan, Shishir Rastogi
Pigmented villo-nodular synovitis (PVNS) is a common disease entity particularly in the knee joint but its incidence in the foot is quite rare. A case of PVNS of the second toe that presented at the outpatient department with an insidious onset and slowly progressive painful swelling of the toe associated with stiffness is presented. The mass was subsequently excised and the diagnosis confirmed by histo-pathology samples. The patient's symptoms improved significantly after the operation. This case is one of the very few reported cases of PVNS involvement of flexor tendon sheath of the foot...
August 2016: Foot
https://www.readbyqxmd.com/read/27698855/aneurysmal-bone-cyst-of-the-metatarsal-a-case-report
#10
Jiangyinzi Shang, Runsheng Guo, Ping Zhan, Chuwen Chen, Jing Kan, Hucheng Liu, Min Dai
An aneurysmal bone cyst (ABC) is a rare, non-neoplastic, destructive, hemorrhagic and expansile lesion accounting for 1% of all bone tumors. This type of lesion predominantly affects long bones and vertebrae. ABC of the metatarsal is rare and only a few cases have been reported in the literature to date. The present study reports a rare case of ABC of the third metatarsal occurring in a 27-year-old male patient, who presented with repeated foot swelling that had lasted for ~1 year. Other clinical manifestations included limping, multiple lumps (defined as masses on or below the skin, as detected by imageological diagnosis) and progressively increasing local pain in his right foot...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27690011/aquaporin-4-a-potential-therapeutic-target-for-cerebral-edema
#11
Guanghui Tang, Guo-Yuan Yang
Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments suggests the function of aquaporin-4 in water transfer into and out of the brain parenchyma. Accumulating evidences have suggested that the dysregulation of aquaporin-4 relates to the brain edema resulting from a variety of neuro-disorders, such as ischemic or hemorrhagic stroke, trauma, etc...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27670520/burden-assessment-of-podoconiosis-in-wayu-tuka-woreda-east-wollega-zone-western-ethiopia-a-community-based-cross-sectional-study
#12
Kenate Bekele, Kebede Deribe, Tsige Amberbir, Geleta Tadele, Gail Davey, Abdi Samuel
OBJECTIVE: Podoconiosis is a neglected tropical disease characterised by a slowly progressive swelling of the foot and lower leg. It is prevalent among subsistence barefoot farmers who live and work in highland areas of the tropics. This study was conducted in Wayu Tuka 'woreda' (district), western Ethiopia to determine the prevalence of podoconiosis and assess factors associated with acute adenolymphangitis (ALA) episodes. METHODS AND ANALYSIS: A two phase, community-based cross-sectional study was conducted between January and March 2015...
September 26, 2016: BMJ Open
https://www.readbyqxmd.com/read/27594952/intra-articular-osteoid-osteoma-of-the-calcaneus-a-case-report-and-review
#13
Tomo Hamada, Hidenori Matsubara, Hiroaki Kimura, Takao Aikawa, Yasuhisa Yoshida, Hiroyuki Tsuchiya
Osteoid osteoma of the calcaneus is rare and frequently misdiagnosed as arthritis because of similar symptoms. In addition, radiographic findings may be nonspecific, and magnetic resonance imaging (MRI) may show a bone marrow edema and changes in adjacent soft tissue. A 19-year-old man presented with a 6-month history of persistent pain and swelling in the left hind foot; diagnostic computed tomography and MRI analyses revealed lesions suggesting an intra-articular osteoid osteoma of the calcaneus. Initial MRI did not show specific findings...
September 2016: Radiology case reports
https://www.readbyqxmd.com/read/27587374/bone-marrow-edema-syndrome-in-the-foot-and-ankle
#14
REVIEW
Seyed Alireza Mirghasemi, Elly Trepman, Mohammad Saleh Sadeghi, Narges Rahimi, Shervin Rashidinia
: Bone marrow edema syndrome (BMES) is an uncommon and self-limited syndrome characterized by extremity pain of unknown etiology. Symptoms may include sudden or gradual onset of swelling and pain at rest or during activity, usually at night. This syndrome mostly affects middle-aged men and younger women who have pain in the lower extremities. The most common sites involved with BMES, in decreasing order of frequency, are the bones about the hip, knee, ankle, and foot. The diagnosis of BMES is confirmed with magnetic resonance imaging to exclude other causes of bone marrow edema...
December 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27539651/musculoskeletal-ultrasonography-delineates-ankle-symptoms-in-rheumatoid-arthritis
#15
Yukihiro Toyota, Maasa Tamura, Yohei Kirino, Yumiko Sugiyama, Naomi Tsuchida, Yosuke Kunishita, Daiga Kishimoto, Reikou Kamiyama, Yasushi Miura, Kaoru Minegishi, Ryusuke Yoshimi, Atsuhisa Ueda, Hideaki Nakajima
OBJECTIVES: To clarify the use of musculoskeletal ultrasonography (US) of ankle joints in rheumatoid arthritis (RA). METHODS: Consecutive RA patients with or without ankle symptoms participated in the study. The US, clinical examination (CE), and patients' visual analog scale for pain (pVAS) for ankles were assessed. Prevalence of tibiotalar joint synovitis and tenosynovitis were assessed by grayscale (GS) and power Doppler (PD) US using a semi-quantitative grading (0-3)...
September 1, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27534086/-study-on-dinggui-gel-paste-on-analgesic-and-anti-inflammatory-effects
#16
Li-yang Zhu, Jian Ma, He Tu, Nan Zeng, Meng Xiang, Rui Wang
OBJECTIVE: To observe effects and mechanism of Dinggui gel paste analgesic anti-inflammatory. METHODS: Eighty-four male KM mice weighted from 18 to 22 g and aged 4 to 5 weeks were randomly divided into 7 groups, named blank group, model group, matrix control group, Votalin group, high dosage of Dinggui gel paste group with group, equivalent dosage of Dinggui gel paste group, Dinggui gel paste group, 12 mice in each group. Except blank and model group, the other groups were paste ointment for 7 days, and one time a day, matrix control group were pasted isodose blank matrix gel patch...
June 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/27512252/functional-limitations-due-to-foot-involvement-in-spondyloarthritis
#17
Nihal Ozaras, Nuri Havan, Emine Poyraz, Aylin Rezvanı, Teoman Aydın
[Purpose] Spondyloarthritis is a major inflammatory disease followed-up in the rheumatology clinics, foot involvement in spodyloarthritis is common. The functional states of patients with spondyloarthritis are usually evaluated globally. The aim of this study was to assess the foot involvement-related functional limitations in patients with spondyloarthritis. [Subjects and Methods] Patients with ankylosing spondylitis and psoriatic arthritis with foot pain more than 4 weeks who underwent anteroposterior and lateral feet radiography were enrolled into the study...
July 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27509583/from-man-to-fish-what-can-zebrafish-tell-us-about-apol1-nephropathy
#18
Opeyemi Olabisi, Khaldoun Al-Romaih, Joel Henderson, Ritu Tomar, Iain Drummond, Calum MacRae, Martin Pollak
BACKGROUND: Risk variant Apolipoprotein L1 (G1/G2) are strongly associated with a spectrum of kidney disease in people of recent African descent. The mechanism of ApoL1 nephropathy is unknown. Podocytes and/or endothelial cells are the presumed target kidney cells. Given the close homology in structure and function of zebrafish (ZF) pronephros and human nephron, we studied the effect of podocyte-specific or endothelium-specific expression of ApoL1 (G0, G1, or G2) on the structure and function of ZF pronephros...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27446605/charcot-arthropathy-in-ultrasound-examination-a-case-report
#19
Mateusz Płaza, Anna Nowakowska-Płaza, Marta Walentowska-Janowicz, Marek Chojnowski, Iwona Sudoł-Szopińska
This article presents a patient with a long history of type 1 diabetes mellitus complicated with neuropathy and Charcot disease. The most common cause of neuropathic osteoarthropathy, called Charcot osteoarthropathy, is poorly controlled diabetes. The clinical picture is characterized by considerable edema, redness and increased skin temperature with relatively slight pain due to injury to nerve fibers responsible for pain sensation. The differential diagnosis should include bacterial or autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury...
June 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/27445607/successful-treatment-of-lower-limb-complex-regional-pain-syndrome-following-three-weeks-of-hyperbaric-oxygen-therapy
#20
Rita Katznelson, Shira C Segal, Hance Clarke
Hyperbaric oxygen therapy (HBOT) is a treatment that delivers 100% oxygen at increased atmospheric pressures. The efficacy of HBOT for treating pain has been described in various animal pain models and may have clinical efficacy in the treatment of human chronic pain syndromes. We present our experience with posttraumatic Complex Regional Pain Syndrome (CRPS) type 2 in a patient who underwent 15 sessions of HBOT. A 41-year-old male with one-year history of CRPS of left foot followed by left ankle fracture demonstrated less pain, decreased swelling, less allodynia, and improvement in skin color and range of motion of the lower limb after 3 weeks of HBOT...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
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