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Methyl cyclodextrin

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https://www.readbyqxmd.com/read/29156883/low-molecular-weight-supramolecular-ionogel-based-on-host-guest-interaction
#1
Aoli Wu, Fei Lu, Panpan Sun, Xuanxuan Qiao, Xinpei Gao, Li-Qiang Zheng
Supramolecular ionogels were prepared by self-assemble of small molecules through host-guest interaction between β-cyclodextrin (β-CD) and a room-temperature ionic liquid (IL) 3-(1-methyl-3-imidazolio)propanesulfonate - lithium bis(trifluoromethanesulfonyl)imide (MIPS-LiTFSI) which contains zwitterion MIPS. 19F NMR and 2D ROESY 1H NMR have been used to prove that only TFSI- is involved in the complexation. 1H NMR, FT-IR and comparative tests indicated that the electrostatic interaction between imidazole cation and TFSI- anion and intermolecular hydrogen bonding between three compounds also contribute to the formation of supramolecular ionogel...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29154925/membrane-cholesterol-depletion-in-cortical-neurons-highlights-altered-nmda-receptor-functionality-in-a-mouse-model-of-amyotrophic-lateral-sclerosis
#2
Alessia Antonini, Silvia Caioli, Luana Saba, Giulia Vindigni, Silvia Biocca, Nadia Canu, Cristina Zona
Amyotrophic Lateral Sclerosis (ALS) is a chronic neurodegenerative disease affecting upper and lower motor neurons, with unknown aetiology. Lipid rafts, cholesterol enriched microdomains of the plasma membrane, have been linked to neurodegenerative disorders like ALS. The NMDA-receptor subcellular localization in lipid rafts is known to play many roles, from modulating memory strength to neurotoxicity. In this study, performed on the widely used G93A mouse model of ALS, we have shown an equal content of total membrane cholesterol in Control and G93A cortical cultures...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29154164/molecular-insights-into-inclusion-complexes-of-mansonone-e-and-h-enantiomers-with-various-%C3%AE-cyclodextrins
#3
Panupong Mahalapbutr, Bodee Nutho, Peter Wolschann, Warinthorn Chavasiri, Nawee Kungwan, Thanyada Rungrotmongkol
The structural dynamics and stability of inclusion complexes of mansonone E (ME) and H (MH) including their stereoisomers with various βCDs (methylated- and hydroxypropylated-βCDs) were investigated by classical molecular dynamics (MD) simulations and binding free energy calculations. The simulation results revealed that mansonones are able to form inclusion complexes with βCDs. The guest molecules are not completely inserted into the host cavity, their preferably positions are nearby the secondary rim with the oxane ring dipping into the hydrophobic inner cavity...
November 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29150591/cholesterol-depletion-does-not-alter-the-capacitance-or-ca-handling-of-the-surface-or-t-tubule-membranes-in-mouse-ventricular-myocytes
#4
Hanne C Gadeberg, Cherrie H T Kong, Simon M Bryant, Andrew F James, Clive H Orchard
Cholesterol is a key component of the cell plasma membrane. It has been suggested that the t-tubule membrane of cardiac ventricular myocytes is enriched in cholesterol and that this plays a role in determining t-tubule structure and function. We have used methyl-β-cyclodextrin (MβCD) to deplete cholesterol in intact and detubulated mouse ventricular myocytes to investigate the contribution of cholesterol to t-tubule structure, membrane capacitance, and the distribution of Ca flux pathways. Depletion of membrane cholesterol was confirmed using filipin; however, di-8-ANEPPS staining showed no differences in t-tubule structure following MβCD treatment...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29141382/-characterization-and-uncertainty-evaluation-of-aqueous-reference-materials-for-cholesterol
#5
W Y Zhou, J Wang, S L Yu, D H Wang, J Zeng, T J Zhang, Y Yan, J T Zhang, W X Chen, C B Zhang
Objective: Characterization and evaluation of the uncertainty of the reference materials of cholesterol in aqueous solution. Methods: The certified reference material GBW09203b was weighed accurately and dissolved into methyl cyclodextrin aqueous solution to prepare six kinds of candidate reference materials of cholesterol according to the concentration. The materials were tested for homogeneity and stability using routine methods and were evaluated the uncertainty derived from the inhomogeneity and instability...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29137913/neutrophil-cd16b-crosslinking-induces-lipid-raft-mediated-activation-of-shp-2-and-affects-cytokine-expression-and-retarded-neutrophil-apoptosis
#6
H Yang, H Jiang, Y Song, D J Chen, X J Shen, J H Chen
Two different types of FcRs for IgG are constitutively expressed on the surface of human neutrophils, namely, FcγRIIA (CD32a) and FcγRIIIB (CD16b). Unlike FcγRIIA, FcγRIIIb is GPI anchored to the cell membrane and its signal transduction is still ambiguous. To further understand the signal transduction of CD16b, we compared neutrophil cytokine expression and apoptosis by the cross-linking of CD32a and CD16b respectively. We found that both CD32a and CD16b crosslinking can activate neutrophils, but did not exactly share cytokine expression profiles...
November 11, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29131506/development-of-a-capillary-electrophoresis-method-for-the-determination-of-the-chiral-purity-of-dextromethorphan-by-a-dual-selector-system-using-quality-by-design-methodology
#7
Sulaiman Krait, Matthias Heuermann, Gerhard K E Scriba
Dextromethorphan is a centrally acting antitussive drug, while its enantiomer levomethorphan is an illicit drug with opioid analgesic effects. As capillary electrophoresis has been proven as an ideal technique for enantiomer analysis, the present study was conducted in order to develop a capillary-electrophoresis-based limit test for levomethorphan. The analytical target profile was defined that the method should be able to determine levomethorphan with acceptable precision and accuracy at the 0.1 % level. From initial scouting experiments, a dual selector system consisting of sulfated β-cyclodextrin and methyl-α-cyclodextrin was identified...
November 13, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29130958/propofol-through-upregulating-caveolin-3-attenuates-post-hypoxic-mitochondrial-damage-and-cell-death-in-h9c2-cardiomyocytes-during-hyperglycemia
#8
Fan Deng, Shuang Wang, Liangqing Zhang, Xiang Xie, Shuyun Cai, Haobo Li, Gui-Ling Xie, Hui-Lai Miao, Changmin Yang, Xin Liu, Zhengyuan Xia
BACKGROUND/AIMS: Hearts from diabetic subjects are susceptible to myocardial ischemia reperfusion (I/R) injury. Propofol has been shown to protect against myocardial I/R injury due to its antioxidant properties while the underlying mechanism remained incompletely understood. Thus, this study aimed to determine whether or not propofol could attenuate myocardial I/R injury by attenuating mitochondrial dysfunction/damage through upregulating Caveolin (Cav)-3 under hyperglycemia. METHODS: Cultured rat cardiomyocyte H9C2 cells were subjected to hypoxia/reoxygenation (H/R) in the absence or presence of propofol under high glucose (HG), and cell viability, lactate dehydrogenase (LDH) and mitochondrial viability as well as creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) and intracellular adenosine triphosphate (ATP) content were measured with colorimetric Enzyme-Linked Immunosorbent Assays...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29127906/exploring-the-intermolecular-interactions-acting-in-solvent-modified-mekc-by-molecular-dynamics-and-nmr-the-effect-of-n-butanol-on-the-separation-of-diclofenac-and-its-impurities
#9
Claudia Caprini, Benedetta Pasquini, Fabrizio Melani, Massimo Del Bubba, Alessandro Giuffrida, Enrica Calleri, Serena Orlandini, Sandra Furlanetto
An integrated approach involving CE experiments, Molecular Dynamics (MD) simulations and two-dimensional NOE spectroscopy (2D-NOESY) experiments was employed to elucidate the intermolecular interactions and the separation mechanisms involved in a solvent-modified MEKC method for the simultaneous determination of diclofenac sodium and its impurities. The CE findings indicated that the addition of n-butanol (nBuOH) to the SDS micellar solution played a primary role for controlling the partitioning into the mixed micelles and the migration of the analytes and that the presence of nBuOH as cosurfactant was compulsory for achieving the complete separation of the compounds...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29120189/thermodynamics-of-methyl-%C3%AE-cyclodextrin-induced-lipid-vesicle-solubilization-effect-of-lipid-headgroup-and-backbone
#10
José Carlos Bozelli, Yu Heng Hou, Richard M Epand
The low aqueous solubility of phospholipids makes necessary the use of lipid carriers in studies ranging from lipid traffic and metabolism to the engineering of model membranes bearing lipid transverse asymmetry. One particular lipid carrier that has proven to be particularly useful is methyl-β-cyclodextrin (MβCD). In order to assess the interaction of MβCD with structurally different phospholipids, the present work reports the results of isothermal titration calorimetry in conjunction with dynamic light scattering measurements...
November 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29118431/mechanotransduction-of-matrix-stiffness-in-regulation-of-focal-adhesion-size-and-number-reciprocal-regulation-of-caveolin-1-and-%C3%AE-1-integrin
#11
Yi-Chun Yeh, Jin-Ying Ling, Wan-Chun Chen, Hsi-Hui Lin, Ming-Jer Tang
Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and caveolin-1 (Cav1) levels were decreased with declining matrix stiffness. Soft matrix selectively downregulated β1 integrin by endocytosis and subsequent lysosomal degradation. Disruption of lipid rafts with methyl-β-cyclodextrin or nystatin, or knockdown of Cav1 by siRNA decreased cell spreading, FA assembly, and β1 integrin protein levels in cells cultured on stiff matrix...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114329/structural-diversity-in-the-host-guest-complexes-of-the-antifolate-pemetrexed-with-native-cyclodextrins-gas-phase-solution-and-solid-state-studies
#12
Magdalena Ceborska, Magdalena Zimnicka, Aneta Aniela Kowalska, Kajetan Dąbrowa, Barbara Repeć
The complexation of the antifolate pemetrexed (PTX) with native cyclodextrins was studied. This process, along with the findings gathered for the structurally related folic acid was treated as a model for exploiting host-guest interactions of this class of guest molecules in the gas phase, in solution and in the solid state. Mass spectrometry was employed for the investigation of the architecture and relative gas-phase stabilities of these supramolecular complexes. The mode of complexation was further tracked by 1D and 2D NMR proving the formation of the exclusion-type complex with α-CD and pseudorotaxane inclusion-type complexes with β-, and γ-CDs...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29113348/sustained-releasing-hollow-microparticles-with-dual-anticancer-drugs-elicit-greater-shrinkage-of-tumor-spheroids
#13
Jong-Suep Baek, Chee Chong Choo, Nguan Soon Tan, Say Chye Joachim Loo
Polymeric particulate delivery systems are vastly explored for the delivery of chemotherapeutic agents. However, the preparation of polymeric particulate systems with the capability of providing sustained release of two or more drugs is still a challenge. Herein, poly (D, L-lactic-co-glycolic acid, 50:50) hollow microparticles co-loaded with doxorubicin and paclitaxel were developed through double-emulsion solvent evaporation technique. Hollow microparticles were formed through the addition of an osmolyte into the fabrication process...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113131/interaction-of-%C3%AE-and-%C3%AE-zearalenols-with-%C3%AE-cyclodextrins
#14
Miklós Poór, Afshin Zand, Lajos Szente, Beáta Lemli, Sándor Kunsági-Máté
Zearalenone (ZEN) is a mycotoxin produced by Fusarium fungi. ZEN primarily contaminates different cereals, and exerts a strong xenoestrogenic effect in animals and humans. ZEN is a fluorescent mycotoxin, although molecular interactions and microenvironmental changes significantly modify its spectral properties. During biotransformation, ZEN is converted into α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL), the toxic metabolites of ZEN, which mimick the effect of estrogen. Cyclodextrins (CDs) are host molecules, and have been studied extensively; they can form stable complexes with several mycotoxins, including ZEN...
November 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29103957/basolateral-cholesterol-depletion-alters-aquaporin-2-post-translational-modifications-and-disrupts-apical-plasma-membrane-targeting
#15
Hanne B Moeller, Cecilia Hvitfeldt Fuglsang, Cecilie Nøhr Pedersen, Robert A Fenton
Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis. Posttranslational modification (PTM) of AQP2 is important for regulating AQP2 trafficking. The aim of this study was to determine the role of cholesterol in regulation of AQP2 PTM and in apical plasma membrane targeting of AQP2. Cholesterol depletion from the basolateral plasma membrane of a collecting duct cell line (mpkCCD14) using methyl-beta-cyclodextrin (MBCD) increased AQP2 ubiquitylation...
November 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29102889/identification-of-the-caveolae-raft-mediated-endocytosis-as-the-primary-entry-pathway-for-aquareovirus
#16
Fuxian Zhang, Hong Guo, Jie Zhang, Qingxiu Chen, Qin Fang
Grass carp reovirus (GCRV), a member of the Aquareovirus genus in the Reoviridae family, is considered the most pathogenic aquareovirus. However, its productive viral entry pathways remain largely unclear. Using a combination of quantum dot (QD)-based live-virus tracking and biochemical assays, we found that extraction of cellular membrane cholesterol with methyl-β-cyclodextrin (MβCD) and nystatin strongly inhibited the internalization of GCRVs, and supplementation with cholesterol restored viral infection...
November 2, 2017: Virology
https://www.readbyqxmd.com/read/29068544/cisplatin-rich-polyoxazoline-poly-aspartic-acid-supramolecular-nanoparticles
#17
Peng Zhang, Kangjun Yuan, Cheng Li, Xiaoke Zhang, Wei Wu, Xiqun Jiang
Cisplatin-rich supramolecular nanoparticles are constructed through the supramolecular inclusion interaction between the admantyl (Ad)-terminated poly(aspartic acid) (Ad-P(Asp)) and the β-cyclodextrin (β-CD)-terminated poly(2-methyl-2-oxazoline). In the formation of the nanoparticles, the β-CD/admantane inclusion complex integrates poly(2-methyl-2-oxazoline) and poly(aspartic acid) chains to form pseudoblock copolymers, followed by the coordination between carboxyl groups in P(Asp) block and cisplatin. This coordination interaction drives the formation of nanoparticle and enables cisplatin incorporated into the nanoparticles...
October 25, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29062407/%C3%AE-cyclodextrin-and-adamantyl-substituted-poly-acrylate-self-assembling-aqueous-networks-designed-for-controlled-complexation-and-release-of-small-molecules
#18
Liang Yan, Duc-Truc Pham, Philip Clements, Stephen F Lincoln, Jie Wang, Xuhong Guo, Christopher J Easton
Three aqueous self-assembling poly(acrylate) networks have been designed to gain insight into the factors controlling the complexation and release of small molecules within them. These networks are formed between 8.8% 6(A)-(2-aminoethyl)amino-6(A)-deoxy-6(A)-β-cyclodextrin, β-CDen, randomly substituted poly(acrylate), PAAβ-CDen, and one of the 3.3% 1-(2-aminoethyl)amidoadamantyl, ADen, 3.0% 1-(6-aminohexyl)amidoadamantyl, ADhn, or 2.9% 1-(12-aminododecyl)amidoadamantyl, ADddn, randomly substituted poly(acrylate)s, PAAADen, PAAADhn and PAAADddn, respectively, such that the ratio of β-CDen to adamantyl substituents is ca...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29054658/influence-of-organic-matter-nutrients-and-cyclodextrin-on-microbial-and-chemical-herbicide-and-degradate-dissipation-in-subsurface-sediment-slurries
#19
Kaisa Kerminen, Romain Le Moël, Vilhelmiina Harju, Merja H Kontro
Pesticides leaching from soil to surface and groundwater are a global threat for drinking water safety, as no cleaning methods occur for groundwater environment. We examined whether peat, compost-peat-sand (CPS) mixture, NH4NO3, NH4NO3 with sodium citrate (Na-citrate), and the surfactant methyl-β-cyclodextrin additions enhance atrazine, simazine, hexazinone, dichlobenil, and the degradate 2,6-dichlorobenzamide (BAM) dissipations in sediment slurries under aerobic and anaerobic conditions, with sterilized controls...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29046458/a-tyrosine-based-trafficking-motif-of-the-tegument-protein-pul71-is-crucial-for-human-cytomegalovirus-secondary-envelopment
#20
Andrea N Dietz, Clarissa Villinger, Stefan Becker, Manfred Frick, Jens von Einem
The human cytomegalovirus (HCMV) tegument protein pUL71 is required for efficient secondary envelopment and accumulates at the Golgi-derived viral assembly complex (vAC) during infection. Analysis of various C-terminally truncated pUL71 fused to eGFP identified amino acids 23-34 as important determinants for its Golgi localization. Sequence analysis and mutational verification revealed the presence of an N-terminal tyrosine-based trafficking motif (YxxΦ) in pUL71. This led us to hypothesize a requirement of the YxxΦ motif for the function of pUL71 in infection...
October 18, 2017: Journal of Virology
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