keyword
https://read.qxmd.com/read/37805768/-clinical-effects-of-superficial-temporal-artery-lobulated-perforator-flaps-in-repairing-skin-and-soft-tissue-defects-after-temporal-tumor-resection
#21
JOURNAL ARTICLE
X S Liao, W Chen, H F Jiang, J Zhou, Z R Wei, S S Chang, F Zhang, K Y Nie
Objective: To explore the feasibility and clinical effects of using superficial temporal artery lobulated perforator flaps in repairing skin and soft tissue defects after tumor resection in the temporal region. Methods: A retrospective observational study method was used. From March 2017 to October 2022, ten patients with temporal skin tumors were admitted to the Affiliated Hospital of Zunyi Medical University, including six women and four men, with age ranging from 42 to 87 years. Among them, three patients had squamous cell carcinoma and seven patients had basal cell carcinoma, with disease duration ranging from 6 months to 5 years...
June 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/37799358/male-genital-lichen-sclerosus-and-associated-symptoms-range-and-severity-results-of-a-questionnaire-study
#22
JOURNAL ARTICLE
Manu Shah, Birgitta van Bodegraven
BACKGROUND: Male genital lichen sclerosus (MGLS) is a chronic inflammatory condition most often seen in uncircumcised men. It has an association with squamous cell carcinoma of the penis and causes significant morbidity in many men. It may present with a range of symptoms, notably male dyspareunia. The full range of symptoms in individuals has yet to be elucidated. AIM: To identify the range and severity of patient's symptoms using a questionnaire to quantify symptoms, including sexual function and urinary symptoms...
October 2023: Skin Health Dis
https://read.qxmd.com/read/37798371/identification-of-a-serum-based-microrna-signature-that-detects-recurrent-oral-squamous-cell-carcinoma-before-it-is-clinically-evident
#23
JOURNAL ARTICLE
Rebecca Towle, Christopher T D Dickman, Sara A MacLellan, Jiahua Chen, Eitan Prisman, Martial Guillaud, Cathie Garnis
BACKGROUND: Survival rates for oral squamous cell carcinoma (OSCC) have remained poor for decades, a fact largely attributable to late-stage diagnoses and high recurrence rates. We report analysis of serum miRNA expression in samples from patients with high-risk oral lesions (HRL, including OSCC/carcinoma in situ lesions) and healthy non-cancer controls, with the aim of non-invasively detecting primary or recurrent disease before it is clinically evident. METHODS: Discovery, test, and validation sets were defined from a total of 468 serum samples (305 HRL and 163 control samples)...
October 5, 2023: British Journal of Cancer
https://read.qxmd.com/read/37785034/the-role-of-esophagography-in-the-diagnosis-of-orthotopic-esophageal-squamous-cell-carcinoma-in-a-mouse-mode
#24
JOURNAL ARTICLE
Z Yin, H Zhang, K Zhang, H Ying, B Liu
PURPOSE/OBJECTIVE(S): Animal models play an irreplaceable role in pre-clinical studies of various tumors, mainly including xenogeneic/homograft subcutaneous tumor models. However, the subcutaneous transplanted tumor model is separated from the microenvironment of the primary tissue and fail to accurately simulate the growth of tumor cells in vivo. Therefore, orthotopic tumor models play an increasingly important role. For esophageal squamous cell carcinoma, chemotherapy-induced methods have successfully established mouse models of esophageal squamous cell carcinoma, but past experiments have found that it is still a challenge to confirm the success of the mouse model of esophageal cancer...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37783107/strategy-for-characterization-and-quantification-of-fatty-acids-in-plasma-by-parallel-d-0-d-6-dansylhydrazine-derivatization-combined-with-uplc-ms-ms
#25
JOURNAL ARTICLE
Jiangshuo Li, Jing Xu, Ruiping Zhang, Jiuming He, Manjiangcuo Wang, Guanggen Jiao, Zeper Abliz
Fatty acids (FAs) play a vital physiological role in lipid metabolism, which is reported as potential diagnostic biomarker for various diseases. Thus, it is urgent to develop a credible method that can profile FA metabolism with a holistic view. Here, a targeted strategy to screen FAs was developed by parallel labeling with d0 /d6 -dansylhydrazine (d0 /d6 -DnsHz) and using ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) in data-dependent MS/MS (ddMS2 ) mode...
September 22, 2023: Talanta
https://read.qxmd.com/read/37751826/drug-drug-conjugates-self-assembled-nanomedicines-triggered-photo-immuno-therapy-for-synergistic-cancer-treatments
#26
JOURNAL ARTICLE
Haijing Qu, Longmeng Li, Han Chen, Menghuan Tang, Wei Cheng, Tzu-Yin Lin, Lingyan Li, Bin Li, Xiangdong Xue
Although immunotherapies have made progress in cancer treatment, their clinical response rates vary widely and are typically low due to sparse immune cell infiltration (immune "cold") and suppressive tumor immune microenvironment (TIME). A simple yet effective approach that integrates a variety of immune-stimulating and TIME-modulating functions could potentially address this clinical challenge. Herein, we conjugate two small molecules, including a photosensitizer (pyropheophorbide-a, PA) and a Toll-like receptor 7/8 agonist (resiquimod, R848), into prodrug (PA-R848) that self-assembles into PA-R848 esterase responsive nanoparticles (PARE NPs) with 100% drug composition and synergistic photo-/immune- therapeutic effects...
September 24, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37727935/failure-patterns-within-different-histological-types-in-sinonasal-malignancies-making-the-complex-simple
#27
JOURNAL ARTICLE
Qian Liu, Meng Sun, Zekun Wang, Yuan Qu, Jianghu Zhang, Kai Wang, Runye Wu, Ye Zhang, Xiaodong Huang, Xuesong Chen, Jingbo Wang, Jianping Xiao, Junlin Yi, Guozhen Xu, Jingwei Luo
OBJECTIVE: To analyze the failure patterns in patients with different histological subtypes of sinonasal malignancies (SNMs). STUDY DESIGN: Retrospectively gathered data. SETTING: Academic university hospital. METHODS: Patients with SNMs treated at a tertiary referral center between January 1999 and January 2019 were included. We assessed the failure patterns within different histological subtypes. RESULTS: The study included 897 patients...
September 20, 2023: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/37713892/observation-of-hemostatic-effectiveness-and-safety-of-ultrasound-ct-guided-3d-intracavitary-and-interstitial-brachytherapy-in-the-treatment-of-larger-cervical-cancer-with-bleeding-a-retrospective-study
#28
JOURNAL ARTICLE
Yuefeng Hu, Ying Jin, Dongdong Wang, Yunxiu Luo
Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. This study explored the effectiveness and safety of ultrasound-CT guided 3D intracavitary and interstitial brachytherapy (US-CT-3D-IGBT) in the treatment of larger cervical cancer with bleeding. A retrospective study was conducted on 31 patients with larger cervical squamous cell carcinoma (tumor short diameter >4 cm) with vaginal bleeding. US-CT-3D-IGBT was used to deliver a single high-dose prescription of high-risk clinical target volume (HR-CTV) 1000 to 1200 centigray (cGy) to the cervical tumor, followed by conventional intensity-modulated radiation therapy (IMRT) synchronous chemoradiotherapy (45-50 gray (Gy)/25-28 fraction(f)) with weekly cisplatin 25 mg/m2...
September 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37711534/osseous-tissue-engineering-in-the-management-of-mandibular-osteoradionecrosis-an-evaluative-study
#29
JOURNAL ARTICLE
Manimaran Kanakaraj, Marudhamani Chinnannan, Anbu Elangovan Nagarathinam, Ravi Velamor Rangarajan, Avinash Gandi Devadas, Madhan Jeyaraman
INTRODUCTION: Osteoradionecrosis (ORN), a non-infectious, necrotic condition of the bone, occurs as a major complication of radiotherapy to the irradiated site. Simple irrigation of the involved bone to partial or complete resection of the involved bones is being employed in its conventional management. Osseous tissue engineering (OTE) provides a new strategy by regenerating bone cells along with biocompatible scaffolds and micromolecules to produce an engineered osseous tissue. MATERIALS AND METHODS: In this study, mandibular ORN following radiation secondary to oropharyngeal squamous cell carcinoma was included...
2023: Annals of Maxillofacial Surgery
https://read.qxmd.com/read/37711518/evaluation-of-salivary-interleukin-6-in-patients-with-oral-squamous-cell-carcinoma-oral-potentially-malignant-disorders-chronic-periodontitis-and-in-healthy-controls-a-cross-sectional-comparative-study
#30
JOURNAL ARTICLE
N Alice Josephine Rani, B G Harsha Vardhan, Srividhya Srinivasan, Saraswathi K Gopal
INTRODUCTION: Oral squamous cell carcinoma (OSCC) accounts for 95% among all head and neck cancers. Literature reveals saliva as a predictive, diagnostic and prognostic tool in carcinoma, inflammatory and genetic disorders. Expression of salivary interleukin-6 (IL-6) has been reported in patients with OSCC and in oral potentially malignant disorders (OPMDs). This study aims at the following objectives: • To evaluate the changes in the salivary levels of IL-6 in healthy individuals and those with chronic periodontitis (CP), OPMD and OSCC...
2023: Annals of Maxillofacial Surgery
https://read.qxmd.com/read/37710407/a-paradigm-shift-in-the-prevention-and-diagnosis-of-oral-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
Jan-Michaél Hirsch, Ronak Sandy, Bengt Hasséus, Joakim Lindblad
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a widespread disease with only 50%-60% 5-year survival. Individuals with potentially malignant precursor lesions are at high risk. METHODS: Survival could be increased by effective, affordable, and simple screening methods, along with a shift from incisional tissue biopsies to non-invasive brush biopsies for cytology diagnosis, which are easy to perform in primary care. Along with the explainable, fast, and objective artificial intelligence characterisation of cells through deep learning, an easy-to-use, rapid, and cost-effective methodology for finding high-risk lesions is achievable...
September 14, 2023: Journal of Oral Pathology & Medicine
https://read.qxmd.com/read/37708874/bioinformatics-analysis-and-screening-of-potential-target-genes-related-to-the-lung-cancer-prognosis
#32
JOURNAL ARTICLE
Ping Huang, Yinfang Gu, Longhua Guo, Xiaofang Zou, Lilan Yi, Guowu Wu
OBJECTIVE: Several genes have been validated as molecular targets for gene therapy in lung cancer. We screened target genes that affect survival of patients with lung cancer. METHODS: Data on gene expression in normal lung tissues/lung adenocarcinoma (LUAD) samples were acquired from Genotype-Tissue Expression (GTEx)/The Cancer Genome Atlas (TCGA) databases and merged to expand the sample size, followed by differential analysis of the merged expression data and acquisition of differentially expressed genes...
September 14, 2023: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/37697335/the-causal-relationship-between-thyroid-function-autoimune-thyroid-dysfunction-and-lung-cancer-a-mendelian-randomization-study
#33
JOURNAL ARTICLE
Xinhui Wang, Xue Liu, Yuchen Li, Mulin Tang, Xue Meng, Yuwei Chai, Li Zhang, Haiqing Zhang
BACKGROUND: The role of thyroid hormones in cancers has been discussed in observational studies; however, the causal relationship between them remains controversial. METHODS: The SNPs associated with hypothyroidism and hyperthyroidism were selected from a FinnGen biobank of 342,499 (190,879 females and 151,620 males) Finnish adult subjects. Data from the Thyroidomics Consortium on 72,167 individuals were used to assess genetically determined thyroid-stimulating hormone (TSH) and free thyroxine (FT4)...
September 11, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37675494/simultaneous-recognition-of-over-and-under-expressed-micrornas-using-nanopore-decoding
#34
JOURNAL ARTICLE
Sotaro Takiguchi, Fumika Kambara, Mika Tani, Tsuyoshi Sugiura, Ryuji Kawano
This paper describes a strategy for simultaneous recognition of over- and under-expressed microRNAs (miRNAs) using the method of signal classification-based nanopore decoding. MiRNA has attracted attention as a promising biomarker for cancer diagnosis owing to its cancer-type-specific expression patterns. While nanopore technology has emerged as a simple and label-free method to detect miRNAs and their expression patterns, recognizing patterns involving simultaneous over/under-expression is still challenging due to the inherent working principles...
September 7, 2023: Analytical Chemistry
https://read.qxmd.com/read/37671816/antioxidant-and-photoprotective-role-of-latex-c-serum-from-hevea-brasiliensis-during-15-week-uvb-irradiation-in-male-hairless-skh-1-mice
#35
JOURNAL ARTICLE
Leandra E Kerche, Iriana M Carrara, Poliana C Marinello, Dalita G S M Cavalcante, Caroline S Danna, Rubens Cecchini, Alessandra L Cecchini, Aldo E Job
It is known that UVB radiation induces several adverse skin alterations starting from simple photoaging to skin cancer. In addition, it was demonstrated that reactive oxygen species (ROS) were found to be related to cancer development and progression. The aim of study was to examine whether male hairless (SKH-1) mice ( Mus musculus ) that were subchronically exposed to UVB radiation presented with actinic keratosis (AK) and squamous cell carcinoma lesions, and that treatment with latex C-serum cream significantly prevented abnormal skin development...
September 6, 2023: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/37653616/a-bacterial-nanomedicine-combines-photodynamic-immunotherapy-and-chemotherapy-for-enhanced-treatment-of-oral-squamous-cell-carcinoma
#36
JOURNAL ARTICLE
Enyu Shi, Tianhe Shan, Hanping Wang, Lujia Mao, Yanjie Liang, Mingxin Cao, Qiqi Wu, Changyi Li, Yue Wang, Yinsong Wang
Bacterial therapy is an emerging hotspot in tumor immunotherapy, which can initiate antitumor immune activation through multiple mechanisms. Porphyromonas gingivalis (Pg), a pathogenic bacterium inhabiting the oral cavity, contains a great deal of pathogen associated molecular patterns that can activate various innate immune cells to promote antitumor immunity. Owing to the presence of protoporphyrin IX (PpIX), Pg is also an excellent photosensitizer for photodynamic therapy (PDT) via the in situ generation of reactive oxygen species...
August 31, 2023: Small
https://read.qxmd.com/read/37580267/-application-of-novel-non-endoscopic-device-in-the-screening-and-early-diagnosis-of-esophageal-cancer
#37
JOURNAL ARTICLE
Z Y Fan, R Chen, W W Wei
Esophageal cancer (EC) is a dreadful disease with a poor prognosis and poses heavy health burden worldwide. Developing effective methods to identify high-risk individuals is urgently needed for preliminary screening before endoscopy. The novel non-endoscopic device has the potential advantages of low cost, simple operation, and minimal invasiveness. Approximately 90% of participants can swallow the device successfully with high safety profiles, and sufficient esophageal exfoliated cells can be collected for cytological examination and biomarker detection...
August 23, 2023: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/37579676/high-sensitive-and-rapid-electrochemical-detection-of-mirna-31-in-saliva-using-cas12a-based-3d-nano-harvester-with-improved-trans-cleavage-efficiency
#38
JOURNAL ARTICLE
Yu Wu, Jingwen Pei, Yi Li, Guobin Wang, Lan Li, Jinbo Liu, Gang Tian
Salivary miRNA-31 is a reliable diagnostic marker for early-stage oral squamous cell carcinoma (OSCC), but accurate detection of miRNA-31 in saliva samples is a challenge because of its low level and high sequence homology. The CRISPR/Cas12a system has the exceptional potential to enable simple nucleic acid analysis but suffers from low speed and sensitivity. To achieve rapid and high-sensitive detection of miRNA-31 using the CRISPR/Cas12a system, a Cas12a-based nano-harvester activated by a polymerase-driven DNA walker, named as dual 3D nanorobots, was developed...
August 10, 2023: Talanta
https://read.qxmd.com/read/37545977/versatility-of-cervicofacial-flap-in-management-of-cutaneous-cheek-defects-post-tumour-excision-a-report-of-two-cases
#39
JOURNAL ARTICLE
Ayodele Ogunkeyede, Remi Solagbade, Adigun Lawal
Reconstructing a large cutaneous cheek defect post tumour excision poses a great challenge to the reconstructive surgeon. The surgical options are limited for a functional and aesthetically acceptable outcome. The microvascular free flap which is currently the gold standard is still not a common place in our practice in Nigeria. Cervicofacial flap, a single stage procedure, offers an excellent alternative as it can be done for patients who are not fit for prolonged anesthesia and can even be undertaken under local anesthesia...
March 2023: African Health Sciences
https://read.qxmd.com/read/37540393/diagnostic-performance-of-endoscopic-ultrasonography-with-water-filled-balloon-method-for-superficial-esophageal-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Yugo Suzuki, Kosuke Nomura, Daisuke Kikuchi, Toshiro Iizuka, Mako Koseki, Yusuke Kawai, Takayuki Okamura, Yorinari Ochiai, Junnosuke Hayasaka, Yutaka Mitsunaga, Hiroyuki Odagiri, Satoshi Yamashita, Akira Matsui, Kenichi Ohashi, Shu Hoteya
BACKGROUND: Endoscopic ultrasonography (EUS) is a commonly used tool for preoperative depth diagnosis of superficial esophageal squamous cell carcinoma (ESCC). Probing EUS using the water-filled balloon method is a simple and safe examination. AIM: The aim of this study was to clarify the diagnostic performance of EUS with the water-filled balloon method for superficial ESCC compared to magnifying narrow-band imaging (ME-NBI). METHODS: We retrospectively examined 403 lesions in 393 consecutive patients diagnosed with ESCC and evaluated them with ME-NBI and EUS...
August 4, 2023: Digestive Diseases and Sciences
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