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simple squamous cell carcinoma

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https://www.readbyqxmd.com/read/27876545/submental-island-flap-reconstruction-in-oral-cavity-cancer-patients-with-level-i-lymph-node-metastasis
#1
P Sittitrai, C Srivanitchapoom, D Reunmakkaew, K Yata
The submental island flap is useful as an alternative to microvascular free tissue transfer for the reconstruction of defects after resection of oral cancer because it is simple to harvest, reliable, and is associated with good oral function and low morbidity. However, because cancer of the oral cavity carries a risk of level I nodal metastases, the oncological safety of the flap remains controversial. Between April 2012 and September 2016, we studied patients with squamous cell carcinoma of the oral cavity who underwent surgical resection with submental island flap reconstruction for viability of the flap, signs of recurrence, and complications...
November 19, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27796187/real-world-approach-to-actinic-keratosis-management-practical-treatment-algorithm-for-office-based-dermatology
#2
Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B E Jemec, Josep Malvehy, Ketty Peris, Susana Puig, Alexander J Stratigos, Iris Zalaudek, Giovanni Pellacani
Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27789946/real-time-colorimetric-detection-of-dna-methylation-of-the-pax1-gene-in-cervical-scrapings-for-cervical-cancer-screening-with-thiol-labeled-pcr-primers-and-gold-nanoparticles
#3
Jin Huang, Yu-Ligh Liou, Ya-Nan Kang, Zhi-Rong Tan, Ming-Jing Peng, Hong-Hao Zhou
BACKGROUND: DNA methylation can induce carcinogenesis by silencing key tumor suppressor genes. Analysis of aberrant methylation of tumor suppressor genes can be used as a prognostic and predictive biomarker for cancer. In this study, we propose a colorimetric method for the detection of DNA methylation of the paired box gene 1 (PAX1) gene in cervical scrapings obtained from 42 patients who underwent cervical colposcopic biopsy. METHODS: A thiolated methylation-specific polymerase chain reaction (MSP) primer was used to generate MSP products labeled with the thiol group at one end...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27747114/intracystic-primary-squamous-cell-carcinoma-of-the-breast-a-challenging-diagnosis
#4
Vera Ramos, João Fraga, Teresa Simões, Margarida Figueiredo Dias
We report a case of a 36-year-old woman that presented with a painful mass in the outer quadrants of the left breast that had grown rapidly. Physical examination revealed a well circumscribed elastic mass and breast ultrasound showed a cyst measuring 26 mm with vegetation growing on the inner wall. Microscopic evaluation, after fine needle aspiration cytology (FNAC), suggested benign lesion. Tumorectomy was performed and the final diagnosis was a pure squamous cell carcinoma (SCC) of the breast. A simple mastectomy with sentinel node biopsy was performed...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27742375/combined-isolated-trigeminal-and-facial-neuropathies-from-perineural-invasion-by-squamous-cell-carcinoma-a-case-series-and-review-of-the-literature
#5
REVIEW
Pierre R Bourque, Gabrielle Bourque, William Miller, John Woulfe, Jodi Warman Chardon
Perineural invasion is a targeted cellular proliferation guided by neurotrophins, rather than a simple diffusion of tumor in a path of least resistance. Invasion of cranial nerves by squamous cell carcinoma can represent an important diagnostic dilemma. It commonly presents as a distinct clinical neurological syndrome of combined isolated trigeminal and facial neuropathies. The focal cancer source may have been overlooked or remain occult. This case series illustrates diverse clinical presentations and neuroimaging challenges in four patients with squamous cell carcinoma of the cranial nerves...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27734748/cost-analysis-of-cetuximab-erbitux-plus-radiotherapy-ert-versus-concomitant-cisplatin-plus-radiotherapy-crt-within-an-nhs-oncology-unit-single-institution-a-pilot-study
#6
Brammer Caroline, Yahya Sundus, Dawson Dawn, Glaister Carol, Merrick Susan
OBJECTIVE: The aim of this feasibility study is to define the resource effectiveness of cetuximab vs cisplatin given concomitantly with radiotherapy for squamous cell carcinoma within a National Health Service clinical oncology unit. METHODS: 20 patients with Stage 3 or 4 head and neck squamous cell cancers were randomized to receive either cetuximab with radiotherapy (ERT) or cisplatin with radiotherapy concurrent with external beam radiotherapy 70 Gy in 35 fractions on a 1 : 1 basis over a 12-month duration...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27731549/worldwide-esophageal-cancer-collaboration-clinical-staging-data
#7
T W Rice, C Apperson-Hansen, L M DiPaola, M E Semple, T E M R Lerut, M B Orringer, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, B P L Wijnhoven, K N Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, W H Allum, I Cecconello, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, H Ishwaran, E H Blackstone
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27731548/worldwide-esophageal-cancer-collaboration-neoadjuvant-pathologic-staging-data
#8
T W Rice, T E M R Lerut, M B Orringer, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, J van Lanschot, K N Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, W H Allum, I Cecconello, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, H Ishwaran, C Apperson-Hansen, L M DiPaola, M E Semple, E H Blackstone
To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27731547/worldwide-esophageal-cancer-collaboration-pathologic-staging-data
#9
T W Rice, L-Q Chen, W L Hofstetter, B M Smithers, V W Rusch, B P L Wijnhoven, K L Chen, A R Davies, X B D'Journo, K A Kesler, J D Luketich, M K Ferguson, J V Räsänen, R van Hillegersberg, W Fang, L Durand, I Cecconello, W H Allum, R J Cerfolio, M Pera, S M Griffin, R Burger, J-F Liu, M S Allen, S Law, T J Watson, G E Darling, W J Scott, A Duranceau, C E Denlinger, P H Schipper, T E M R Lerut, M B Orringer, H Ishwaran, C Apperson-Hansen, L M DiPaola, M E Semple, E H Blackstone
We report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision...
October 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27721596/the-synergy-of-tobacco-and-alcohol-and-glutathione-s-transferase-%C3%AE-1-gene-deletion-and-oral-squamous-cell-carcinoma
#10
Sarah D' Mello, Radhika Manoj Bavle, K Paremala, Soumya Makarla, M Sudhakara, Madhura Bhatt
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the leading cancer among males in India. It is related to tobacco habits and alcohol consumption as well as the individual susceptibility for xenobiotic metabolizing enzyme polymorphisms. Glutathione S-transferase θ 1 (GSTT1) is a Phase II metabolic enzyme which is directly involved in catalyzing chemicals to mutagenic intermediates. This gene is characterized by genetic polymorphism resulting in complete gene deletion and subsequent absence of the enzyme, which ultimately dictates the risk of cancer development...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27717818/craniofacial-resection-and-reconstruction-in-patients-with-recurrent-cancer-involving-the-craniomaxillofacial-region
#11
Wei-Liang Chen, Zhao-Hui Yang, Zhi-Quan Huang, Song Fan, Da-Ming Zhang, You-Yuan Wang
PURPOSE: Head and neck tumors that involve the craniomaxillofacial region are classified as stage IVb disease and are clinically challenging. In this study, the outcomes of craniofacial resection and craniofacial reconstruction in patients with recurrent malignant tumors involving the craniomaxillofacial region were evaluated. PATIENTS AND METHODS: This retrospective observational study was conducted from January 2008 to August 2015. Data collected for each patient included age, gender, tumor site, initial treatment, craniofacial resection, reconstruction flaps and complications after craniofacial resection, adjuvant treatment, and reported outcomes of craniofacial resection and craniofacial reconstruction...
September 13, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27684856/successful-treatment-of-cutaneous-squamous-cell-carcinoma-with-intralesional-cryosurgery-case-report
#12
Chaw-Ning Lee, Shin-Chen Pan, Julia Yu-Yun Lee, Tak-Wah Wong
BACKGROUND: Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC. METHODS: Four patients with nodular SCC/keratoacanthoma (tumor size, 1-2...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27667675/comparative-analysis-of-three-histologic-grading-methods-for-squamous-cell-carcinoma-of-the-lip
#13
Luciana Strieder, Cláudia Malheiros Coutinho-Camillo, Victor Costa, Danyel Elias da Cruz Perez, Luiz Paulo Kowalski, Estela Kaminagakura
OBJECTIVES: The aim of this study was to evaluate three histologic grading methods for squamous cell carcinoma (SCC) of the lip, the conventional 3-grade model proposed by the World Health Organization (WHO), tumor budding and depth of invasion (BD) model, and histologic risk assessment (HRA) model, and to correlate them with prognosis. MATERIALS AND METHODS: Fifty-three patients with lip SCC were evaluated. RESULTS: The mean age was 65 years, 69...
September 26, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27661075/exfoliative-cytology-in-the-diagnosis-of-ocular-surface-squamous-neoplasms
#14
Kim Vieira Kayat, Paulo Elias Correa Dantas, Sérgio Felberg, Maria Antonieta Galvão, Mauro Ajaj Saieg
PURPOSE: Surface tumors of the eye comprise an ample spectrum of diseases with various clinical manifestations. Diagnosis has been traditionally achieved through core biopsies, but cytology is an innovative, fast, and minimally invasive method. The objective of this study was to investigate the use of exfoliative cytology as an alternative method for the detection of ocular surface squamous neoplasm (OSSN). METHODS: Exfoliative cytology of the lesions was performed by collecting smears using plastic brushes followed by smearing the cells onto slides and subsequently fixing them in 90% alcohol...
January 2017: Cornea
https://www.readbyqxmd.com/read/27630945/minor-salivary-gland-changes-in-oral-epithelial-dysplasia-and-oral-squamous-cell-carcinoma-a-histopathological-study
#15
Sunil Paramel Mohan, Ravi Teja Chitturi, Yoithapprabhunath Thukanayakanpalayam Ragunathan, Suman Jhansi Lakshmi, Jaisanghar Nallusamy, Isaac Joseph
INTRODUCTION: The most common etiology for Oral Squamous Cell Carcinoma (OSCC) is tobacco and tobacco related products which cause nuclear damage to the keratinocytes. The chemical carcinogens not only affect the lining of oral epithelium but also affect the lining epithelium of the excretory ducts of the salivary glands. Thus, there is a possibility of epithelial dysplasia of the salivary duct epithelium which may lead to potential malignant transformation. AIM: The study was performed to see the changes in the minor salivary glands and excretory ducts in cases of oral epithelial dysplasia and OSCC...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27617821/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#16
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
September 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27613249/laryngeal-cancer-hpv-dna-vs-e6-e7-mrna-test-a-systematic-review
#17
Massimo Fusconi, Flaminia Campo, Andrea Gallo, Giampietro Zambetti, Salvatore Martellucci, Annalisa Seccia, Marco de Vincentiis
OBJECTIVE: The reported range of involvement of human papillomavirus (HPV) in laryngeal squamous cell carcinoma (SCC) is wide because of the methods used to detect HPV. DATA SOURCES: A computerized Medline study was carried out using the following as key words: "Papillomavirus Infections"[Mesh] and "Laryngeal Neoplasms"[Mesh]. MATERIALS AND METHODS: Studies that were included were written in English and reported results of HPV DNA with RNA in laryngeal SCC...
September 6, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27603222/internalization-of-auger-electron-emitting-isotopes-into-cancer-cells-a-method-for-spatial-distribution-determination-of-equivalent-source-terms
#18
Georgina Royle, Nadia Falzone, Radka Chakalova, Katherine Vallis, Sverre Myhra
PURPOSE: A challenge for single-cell dosimetry of internalized Auger electron-emitting (AE) radiopharmaceuticals remains how best to elucidate their spatial distribution. To this end, a method, photoresist autoradiography (PAR), was previously developed to identify the lateral spatial distribution of AE-emitting radionuclides internalized in single cancer cells. In this paper, we present a simple mathematical model based on the radius and depth of radiation-induced patterns in photoresist material to identify the location in the z-plane of an (111)In source capable of generating the pattern...
October 17, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27579613/does-tumor-size-improve-the-accuracy-of-prognostic-prediction-in-patients-with-esophageal-squamous-cell-carcinoma-after-surgical-resection
#19
Hongdian Zhang, Peng Tang, Xiaohui Miao, Yongyin Gao, Xiaobin Shang, Lei Gong, Zhao Ma, Mingjian Yang, Hongjing Jiang, Zhongli Zhan, Bin Meng, Zhentao Yu
This study aimed to investigate whether the inclusion of tumor size could improve the prognostic accuracy in patients with esophageal squamous cell cancer (ESCC). A total of 387 patients with ESCC who underwent curative resection were enrolled in this analysis. The patients were categorized into small-sized tumors (SSTs) and large-sized tumors (LSTs) using an appropriate cut-off point for tumor size. Kaplan-Meier survival curve and log-rank test were used to evaluate the prognostic value of tumor size. A Cox regression model was adopted for multivariate analysis...
August 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27521571/tanshinone-iia-sensitizes-oral-squamous-cell-carcinoma-to-radiation-due-to-an-enhanced-autophagy
#20
Lijuan Ding, Shudong Wang, Xiaozhang Qu, Jiafeng Wang
PURPOSE: Tanshinone IIA (TanIIA), which is derived from the roots of Salvia miltiorrhiza (Danshen), has multiple pharmacological activities. However, the radiosensitivezing activity of TanIIA in oral cancer cells has not been studied extensively. The purpose of this study is to investigate the radiosensitizing effects of TanIIA in human oral squamous cell carcinoma SCC090 and examined the underlying mechanisms. METHODS: Clonogenic assay was used to investigate the radiosensitizing effect of TanIIA on SCC090...
September 2016: Environmental Toxicology and Pharmacology
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