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https://www.readbyqxmd.com/read/28342951/a-model-to-identify-individuals-at-high-risk-for-esophageal-squamous-cell-carcinoma-and-precancerous-lesions-in-regions-of-high-prevalence-in-china
#1
Mengfei Liu, Zhen Liu, Hong Cai, Chuanhai Guo, Xiang Li, Chaoting Zhang, Hui Wang, Dong Hang, Fangfang Liu, Qiuju Deng, Xin Yang, Wenqing Yuan, Yaqi Pan, Jingjing Li, Chanyuan Zhang, Na Shen, Zhonghu He, Yang Ke
BACKGROUND & AIMS: We aimed to develop a population-based model to identify individuals at high-risk for esophageal squamous cell carcinoma (ESCC) in regions of China with a high prevalence of this cancer. METHODS: We collected findings from 15,073 permanent residents (45-69 years old) of 334 randomly selected villages in Hua County, Henan Province, China who underwent endoscopic screening (with iodine staining) for ESCC from January 2012 through September 2015...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28296547/analysis-of-silver-binding-nucleolar-organizer-regions-in-exfoliative-cytology-smears-of-potentially-malignant-and-malignant-oral-lesions
#2
G V Sowmya, P Nahar, M Astekar, H Agarwal, M P Singh
Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Eighty individuals were divided into four equal groups: healthy controls, oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma...
2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28272004/surgical-outcomes-post-neoadjuvant-chemotherapy-in-stage-iv-cancers-of-oral-cavity
#3
(no author information available yet)
AIM: To know the effect of neoadjuvant chemotherapy on surgical outcomes (R1 resections, post-operative complications, recurrence and follow up) in Stage IV borderline operable cancers of oral cavity. MATERIALS AND METHODS: Patients in group A (n=45) were those who were referred for neoadjuvant chemotherapy (NACT) with an intention to operate at a later date. These were compared with 45 patients of group B who were operated upfront. All 90 patients have stage IV squamous cell carcinoma of oral cavity...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28243122/the-lymphocyte-monocyte-ratio-predicts-tumor-response-and-survival-in-patients-with-locally-advanced-esophageal-cancer-who-received-definitive-chemoradiotherapy
#4
Xuemei Liu, Minghuan Li, Fen Zhao, Yingming Zhu, Yijun Luo, Li Kong, Hui Zhu, Yan Zhang, Fang Shi, Jinming Yu
BACKGROUND: The lymphocyte-monocyte ratio (LMR), a simple biomarker that can reflect the antitumor immune response of the host, has been associated with patient prognosis in several solid tumors. The aim of this study was to evaluate whether LMR can predict clinical tumor response and prognosis in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who received definitive chemoradiotherapy (CRT). PATIENTS AND METHODS: A total of 162 advanced ESCC patients treated at our institution between January 2012 and December 2013 were retrospectively recruited for analysis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28235782/development-of-a-multiplexed-lc-mrm-ms-method-for-evaluation-of-salivary-proteins-as-oral-cancer-biomarkers
#5
Yi-Ting Chen, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang
Multiple (selected) reaction monitoring (MRM/SRM) of peptides is a growing technology for target protein quantification because it is more robust, precise, accurate, high-throughput, and multiplex-capable than antibody-based techniques. The technique has been applied clinically to the large-scale quantification of multiple target proteins in different types of fluids. However, previous MRM-based studies have placed less focus on sample-preparation workflow and analytical performance in the precise quantification of proteins in saliva, a non-invasively sampled body fluid...
February 24, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28235445/research-techniques-made-simple-identification-and-characterization-of-long-noncoding-rna-in-dermatological-research
#6
Dario Antonini, Maria Rosaria Mollo, Caterina Missero
Long noncoding RNAs (lncRNAs) are a functionally heterogeneous and abundant class of RNAs acting in all cellular compartments that can form complexes with DNA, RNA, and proteins. Recent advances in high-throughput sequencing and techniques leading to the identification of DNA-RNA, RNA-RNA, and RNA-protein complexes have allowed the functional characterization of a small set of lncRNAs. However, characterization of the full repertoire of lncRNAs playing essential roles in a number of normal and dysfunctional cellular processes remains an important goal for future studies...
March 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28176443/quantitative-phosphoproteomic-analysis-reveals-system-wide-signaling-pathways-regulated-by-site-specific-phosphorylation-on-keratin-8-in-skin-squamous-cell-carcinoma-derived-cell-line
#7
Richa Tiwari, Indrajit Sahu, Bihari Lal Soni, Gajanan J Sathe, Keshava K Datta, Pankaj Thapa, Shruti Sinha, Chella Krishna Vadivel, Bharti Dhaka, Harsha Gowda, Milind M Vaidya
Keratin 8/18, a simple epithelia specific keratin pair, is often aberrantly expressed in squamous cell carcinomas (SCC) where its expression is correlated with increased invasion and poor prognosis. Majority of Keratin 8 (K8) functions are governed by its phosphorylation at Serine(73) (head-domain) and Serine(431) (tail-domain) residues. Although, deregulation of K8 phosphorylation is associated with progression of different carcinomas, its role in skin-SCC and the underlying mechanism is obscure. In this direction, we performed TMT-based quantitative phosphoproteomics by expressing K8 wild type, phosphodead and phosphomimetic mutants in K8-deficient A431 cells...
February 7, 2017: Proteomics
https://www.readbyqxmd.com/read/28155253/characterization-of-key-transcription-factors-as-molecular-signatures-of-hpv-positive-and-hpv-negative-oral-cancers
#8
Gaurav Verma, Kanchan Vishnoi, Abhishek Tyagi, Mohit Jadli, Tejveer Singh, Ankit Goel, Ankita Sharma, Kiran Agarwal, Subhash Chandra Prasad, Durgatosh Pandey, Shashi Sharma, Ravi Mehrotra, Sukh Mahendra Singh, Alok Chandra Bharti
Prior studies established constitutively active AP-1, NF-κB, and STAT3 signaling in oral cancer. Differential expression/activation of specific members of these transcription factors has been documented in HPV-positive oral lesions that respond better to therapy. We performed a comprehensive analysis of differentially expressed, transcriptionally active members of these pivotal signaling mediators to develop specific signatures of HPV-positive and HPV-negative oral lesions by immunohistochemical method that is applicable in low-resource settings...
March 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28103272/prevalence-and-determinants-of-oral-human-papillomavirus-infection-in-500-young-adults-from-italy
#9
Valentina Lupato, Dana Holzinger, Daniela Höfler, Anna Menegaldo, Paolo Giorgi Rossi, Annarosa Del Mistro, Maria Cristina Da Mosto, Michael Pawlita, Paolo Boscolo-Rizzo
Although the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in developed countries and becoming a relevant health issue, the natural history of oral HPV infection is still unclear. Estimating the infection's prevalence in specific populations and identifying risk factors can widen our understanding of its natural history and help to delineate appropriate prevention strategies. This study sought to (i) determine oral HPV prevalence and genotype distribution in a large series of young Italian adults, (ii) validate an oral rinse sampling/storage protocol, and (iii) pinpoint factors associated with oral HPV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28061890/hpv-dna-in-saliva-from-patients-with-scc-of-the-head-and-neck-is-specific-for-p16-positive-oropharyngeal-tumours
#10
Jason K Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection of HPV in patients with HNSCC may expedite treatment when p16 status is not immediately available. METHODS: Saliva-based DNA collection kits and nested polymerase chain reaction (PCR) were used to determine the HPV status of 62 individuals with biopsy-proven HNSCC...
January 6, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28043248/-the-application-of-two-occupation-health-risk-assessment-models-in-a-wooden-furniture-manufacturing-industry
#11
A H Wang, P B Leng, G L Bian, X H Li, G C Mao, M B Zhang
Objective: To explore the applicability of 2 different models of occupational health risk assessment in wooden furniture manufacturing industry. Methods: American EPA inhalation risk model and ICMM model of occupational health risk assessment were conducted to assess occupational health risk in a small wooden furniture enterprises, respectively. Results: There was poor protective measure and equipment of occupational disease in the plant. The concentration of wood dust in the air of two workshops was over occupational exposure limit (OEL) , and the CTWA was 8...
October 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28005741/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#12
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28000729/systemic-immune-inflammation-index-predicts-prognosis-of-patients-with-esophageal-squamous-cell-carcinoma-a-propensity-score-matched-analysis
#13
Yiting Geng, Yingjie Shao, Danxia Zhu, Xiao Zheng, Qi Zhou, Wenjie Zhou, Xuefeng Ni, Changping Wu, Jingting Jiang
Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported in esophageal squamous cell carcinoma (ESCC). We evaluated the prognostic value of the SII in 916 patients with ESCC who underwent radical surgery. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve was used to compare the discrimination ability for OS...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27989009/microrna-from-brush-biopsy-to-characterize-oral-squamous-cell-carcinoma-epithelium
#14
Yalu Zhou, Antonia Kolokythas, Joel L Schwartz, Joel B Epstein, Guy R Adami
Few cancers are diagnosed based on RNA expression signatures. Oral squamous cell carcinoma (OSCC) is no exception; it is currently diagnosed by scalpel biopsy followed by histopathology. This study sought to identify oral tumor epithelial microRNA (miRNA) expression changes to determine if these changes could be used to diagnose the disease noninvasively. Analysis of miRNA profiles from surgically obtained OSCC tissue, collected under highly standardized conditions for The Cancer Genome Atlas, was done to determine the potential accuracy in differentiating tumor from normal mucosal tissue...
January 2017: Cancer Medicine
https://www.readbyqxmd.com/read/27876545/submental-island-flap-reconstruction-in-oral-cavity-cancer-patients-with-level-i-lymph-node-metastasis
#15
P Sittitrai, C Srivanitchapoom, D Reunmakkaew, K Yata
The submental island flap is useful as an alternative to microvascular free tissue transfer for the reconstruction of defects after resection of oral cancer because it is simple to harvest, reliable, and is associated with good oral function and low morbidity. However, because cancer of the oral cavity carries a risk of level I nodal metastases, the oncological safety of the flap remains controversial. Between April 2012 and September 2016, we studied patients with squamous cell carcinoma of the oral cavity who underwent surgical resection with submental island flap reconstruction for viability of the flap, signs of recurrence, and complications...
November 19, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27796187/real-world-approach-to-actinic-keratosis-management-practical-treatment-algorithm-for-office-based-dermatology
#16
Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B E Jemec, Josep Malvehy, Ketty Peris, Susana Puig, Alexander J Stratigos, Iris Zalaudek, Giovanni Pellacani
Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27789946/real-time-colorimetric-detection-of-dna-methylation-of-the-pax1-gene-in-cervical-scrapings-for-cervical-cancer-screening-with-thiol-labeled-pcr-primers-and-gold-nanoparticles
#17
Jin Huang, Yu-Ligh Liou, Ya-Nan Kang, Zhi-Rong Tan, Ming-Jing Peng, Hong-Hao Zhou
BACKGROUND: DNA methylation can induce carcinogenesis by silencing key tumor suppressor genes. Analysis of aberrant methylation of tumor suppressor genes can be used as a prognostic and predictive biomarker for cancer. In this study, we propose a colorimetric method for the detection of DNA methylation of the paired box gene 1 (PAX1) gene in cervical scrapings obtained from 42 patients who underwent cervical colposcopic biopsy. METHODS: A thiolated methylation-specific polymerase chain reaction (MSP) primer was used to generate MSP products labeled with the thiol group at one end...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27747114/intracystic-primary-squamous-cell-carcinoma-of-the-breast-a-challenging-diagnosis
#18
Vera Ramos, João Fraga, Teresa Simões, Margarida Figueiredo Dias
We report a case of a 36-year-old woman that presented with a painful mass in the outer quadrants of the left breast that had grown rapidly. Physical examination revealed a well circumscribed elastic mass and breast ultrasound showed a cyst measuring 26 mm with vegetation growing on the inner wall. Microscopic evaluation, after fine needle aspiration cytology (FNAC), suggested benign lesion. Tumorectomy was performed and the final diagnosis was a pure squamous cell carcinoma (SCC) of the breast. A simple mastectomy with sentinel node biopsy was performed...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27742375/combined-isolated-trigeminal-and-facial-neuropathies-from-perineural-invasion-by-squamous-cell-carcinoma-a-case-series-and-review-of-the-literature
#19
REVIEW
Pierre R Bourque, Gabrielle Bourque, William Miller, John Woulfe, Jodi Warman Chardon
Perineural invasion is a targeted cellular proliferation guided by neurotrophins, rather than a simple diffusion of tumor in a path of least resistance. Invasion of cranial nerves by squamous cell carcinoma can represent an important diagnostic dilemma. It commonly presents as a distinct clinical neurological syndrome of combined isolated trigeminal and facial neuropathies. The focal cancer source may have been overlooked or remain occult. This case series illustrates diverse clinical presentations and neuroimaging challenges in four patients with squamous cell carcinoma of the cranial nerves...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27734748/cost-analysis-of-cetuximab-erbitux-plus-radiotherapy-ert-versus-concomitant-cisplatin-plus-radiotherapy-crt-within-an-nhs-oncology-unit-single-institution-a-pilot-study
#20
RANDOMIZED CONTROLLED TRIAL
Brammer Caroline, Yahya Sundus, Dawson Dawn, Glaister Carol, Merrick Susan
OBJECTIVE: The aim of this feasibility study is to define the resource effectiveness of cetuximab vs cisplatin given concomitantly with radiotherapy for squamous cell carcinoma within a National Health Service clinical oncology unit. METHODS: 20 patients with Stage 3 or 4 head and neck squamous cell cancers were randomized to receive either cetuximab with radiotherapy (ERT) or cisplatin with radiotherapy concurrent with external beam radiotherapy 70 Gy in 35 fractions on a 1 : 1 basis over a 12-month duration...
December 2016: British Journal of Radiology
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