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simple squamous cell carcinoma

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https://www.readbyqxmd.com/read/29765149/masan-a-novel-staging-system-for-prognosis-of-patients-with-oesophageal-squamous-cell-carcinoma
#1
Wei Liu, Jian-Zhong He, Shao-Hong Wang, De-Kai Liu, Xue-Feng Bai, Xiu-E Xu, Jian-Yi Wu, Yong Jiang, Chun-Quan Li, Long-Qi Chen, En-Min Li, Li-Yan Xu
BACKGROUND: Oesophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers worldwide. Treatment of ESCC is in progress through accurate staging and risk assessment of patients. The emergence of potential molecular markers inspired us to construct novel staging systems with better accuracy by incorporating molecular markers. METHODS: We measured H scores of 23 protein markers and analysed eight clinical factors of 77 ESCC patients in a training set, from which we identified an optimal MASAN (MYC, ANO1, SLC52A3, Age and N-stage) signature...
May 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#2
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29669525/salivary-extracellular-vesicle-associated-mirnas-as-potential-biomarkers-in-oral-squamous-cell-carcinoma
#3
Chiara Gai, Francesco Camussi, Roberto Broccoletti, Alessio Gambino, Marco Cabras, Luca Molinaro, Stefano Carossa, Giovanni Camussi, Paolo G Arduino
BACKGROUND: Several studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs associated with extracellular vesicles (EVs) are known to be protected from enzymatic degradation, we evaluated whether salivary EVs from patients with oral squamous cell carcinoma (OSCC) were enriched with specific subsets of miRNAs. METHODS: OSCC patients and controls were matched with regards to age, gender and risk factors...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29617785/extended-bronchoplasty-for-locally-advanced-left-lower-lobe-lung-cancer-surgical-technique-and-outcomes
#4
Tomoyuki Hishida, Keiju Aokage, Junji Yoshida, Tomohiro Miyoshi, Masahiro Tsuboi
Extended bronchoplasty combined with left lower lobectomy plus lingulectomy can be indicated for some locally advanced left lower lobe cancers to avoid pneumonectomy, but its outcome has not been well studied. We retrospectively analysed the surgical outcomes of 10 patients since 2008, when we introduced this procedure. The median age was 67 years (range 42-80). Squamous cell carcinoma was the most common histology. The indication for this procedure was bulky or extranodal metastasis in an interlobar node in 9 patients and massive tumour invasion to the lingula in 1 patient...
April 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29609610/robotic-sleeve-resection-for-pulmonary-disease
#5
Chengqiang Li, Bin Zhou, Yu Han, Runsen Jin, Jie Xiang, Hecheng Li
BACKGROUND: Few studies have described robotic sleeve resection with pulmonary resection. Here, we report the successful implementation of a completely portal robotic sleeve resection with or without pulmonary resection using a modified suture mode. METHODS: In total, 339 patients underwent curative robotic pulmonary surgery at Ruijin Hospital between May 2015 and September 2017. Three of these patients underwent robotic sleeve resection (right upper lobe, one; left upper lobe, one; and lingular segmental bronchus, one)...
April 2, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29607184/thoracoscopic-right-s6-sleeve-segmentectomy-for-squamous-cell-carcinoma-arising-from-the-b6-central-bronchus
#6
Takuya Nagashima, Kenji Inui, Kenji Kanno, Hiroyuki Ito, Haruhiko Nakayama
We describe a patient with low respiratory function who underwent thoracoscopic sleeve segmentectomy to preserve lung function as much as possible. The patient had already used home oxygen therapy because of chronic obstructive lung disease. There was a squamous-cell carcinoma at inlet of right B6 bronchus, and cT1aN0M0 disease was diagnosed. Because respiratory function was poor, right S6 segmentectomy was scheduled. Moreover, to preserve the respiratory muscles as much as possible, a thoracoscopic approach was selected...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29604042/higher-carbohydrate-intake-is-associated-with-increased-risk-of-all-cause-and-disease-specific-mortality-in-head-and-neck-cancer-patients-results-from-a-prospective-cohort-study
#7
Anna E Arthur, Amy M Goss, Wendy Demark-Wahnefried, Alison M Mondul, Kevin R Fontaine, Yi Tang Chen, William R Carroll, Sharon A Spencer, Laura Q Rogers, Laura S Rozek, Gregory T Wolf, Barbara A Gower
No studies have evaluated associations between carbohydrate intake and head and neck squamous cell carcinoma (HNSCC) prognosis. We prospectively examined associations between pre- and post-treatment carbohydrate intake and recurrence, all-cause mortality, and HNSCC- specific mortality in a cohort of 414 newly diagnosed HNSCC patients. All participants completed pre- and post-treatment Food Frequency Questionnaires (FFQs) and epidemiologic surveys. Recurrence and mortality events were collected annually. Multivariable Cox Proportional Hazards models tested associations between carbohydrate intake (categorized into low, medium and high intake) and time to recurrence and mortality, adjusting for relevant covariates...
March 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29581759/the-value-of-preoperative-glasgow-prognostic-score-and-the-c-reactive-protein-to-albumin-ratio-as-prognostic-factors-for-long-term-survival-in-pathological-t1n0-esophageal-squamous-cell-carcinoma
#8
Xiangyang Yu, Yingsheng Wen, Yongbin Lin, Xuewen Zhang, Yongqiang Chen, Weidong Wang, Gongming Wang, Lanjun Zhang
Plenty of studies have confirmed the prognostic values of inflammation-based prognostic scores in many malignant tumors. In present study, we aim to explore whether these indexes has same prognostic values in patients with stage T1N0 esophageal squamous cell carcinoma (ESCC). The clinicopathological data of 160 consecutive patients with pathological stage T1N0 ESCC from January 2005 to December 2012 were collected retrospectively. As prognostic factors, the inflammation-based prognostic scores, including C-reactive protein (CRP), Glasgow prognostic score (GPS), prognostic index (PI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and CRP to albumin ratio (CAR), were evaluated...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29461376/modified-unilateral-pedicled-v-y-advancement-flap-for-scalp-defect-repair
#9
Hua Shen, Xinyi Dai, Jun Chen, Jing Wang, Zhaofen Zhang, Zhengdong Cai
Reconstruction of scalp defects caused by tumor resection or trauma is very challenging. A majority of the surgeons prefer to use local flap rather than skin graft or free flap for scalp defects repair. The aim of this study is to investigate the technique of modified unilateral pedicled V-Y advancement flap for the reconstruction of scalp defect.A retrospective review was performed in a series of 18 patients who had a modified unilateral pedicled V-Y advancement flap to restore scalp defect from May 2013 to January 2017...
May 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460840/-comparative-sub-population-analysis-of-exosomes-from-blood-plasma-of-cancer-patients
#10
REVIEW
S N Tamkovich, N V Yunusova, A K Somov, G V Kakurina, E S Kolegova, E A Tugurova, P P Laktionov, I V Kondakova
To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes...
January 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29427328/depletion-of-keratin-8-18-modulates-oncogenic-potential-by-governing-multiple-signaling-pathways
#11
Richa Tiwari, Indrajit Sahu, Bihari Lal Soni, Gajanan J Sathe, Pankaj Thapa, Pavan Patel, Shruti Sinha, Chella Krishna Vadivel, Shweta Patel, Sayli Nitin Jamghare, Swapnil Oak, Rahul Thorat, Harsha Gowda, Milind M Vaidya
Keratin 8/18, the predominant keratin pair of simple epithelia, is often aberrantly expressed in various squamous cell carcinomas (SCCs) including skin SCC. Its aberrant expression is correlated with increased invasiveness and poor prognosis of the same, although the underlying mechanism is still unclear. A previous report from our laboratory has shown K8-mediated regulation of α6β4 integrin signaling and thereby tumorigenic potential of oral SCC-derived cells. Another study on transgenic mouse model has shown that during skin carcinogenesis, K8 favors conversion of papillomas toward malignancy...
April 2018: FEBS Journal
https://www.readbyqxmd.com/read/29427291/prognostic-impact-of-tumour-stroma-ratio-in-early-stage-oral-tongue-cancers
#12
Alhadi Almangush, Ilkka Heikkinen, Nassira Bakhti, Laura K Mäkinen, Joonas H Kauppila, Matti Pukkila, Jaana Hagström, Jussi Laranne, Ylermi Soini, Luiz P Kowalski, Reidar Grénman, Caj Haglund, Antti A Mäkitie, Ricardo D Coletta, Ilmo Leivo, Tuula Salo
AIMS: Oral tongue squamous cell carcinoma (OTSCC) has a relatively poor outcome, and there is a need to identify better prognostic factors. Recently, tumour-stroma ratio (TSR) has been associated with prognosis in several cancers. The aim of this multi-institutional study was to evaluate the prognostic value of TSR from original haematoxylin and eosin (HE)-stained tumour-resection slides in a series of early-stage (cT1-2N0) OTSCC patients. METHODS AND RESULTS: A TSR cutoff value of 50% was used to divide the patients into stroma-rich (≥50%) and stroma-poor (<50%) groups...
February 10, 2018: Histopathology
https://www.readbyqxmd.com/read/29393297/the-histologic-risk-model-is-a-useful-and-inexpensive-tool-to-assess-risk-of-recurrence-and-death-in-stage-i-or-ii-squamous-cell-carcinoma-of-tongue-and-floor-of-mouth
#13
Namita Sinha, Matthew H Rigby, Michael L McNeil, S Mark Taylor, Jonathan Rb Trites, Robert D Hart, Martin J Bullock
Surgery is the mainstay of treatment for low-stage (stage I/II, ie, T1N0/T2N0) squamous cell carcinoma of oral cavity. However, a significant percentage of low-stage squamous cell carcinoma of oral cavity will develop local recurrence and disease-related mortality. In this study, we stratified 64 patients with low-stage of oral tongue and floor of mouth patients into high-, intermediate- and low-risk categories based on existing histologic risk model. The classification of these risk categories was based on presence or absence of perineural invasion and evaluation of tumor-host junction for worst pattern of invasion and lymphocytic host response...
February 2, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29361818/preclinical-study-of-novel-curcumin-analogue-ssc-5-using-orthotopic-tumor-xenograft-model-for-esophageal-squamous-cell-carcinoma
#14
Lai Nar Tung, Senchuan Song, Kin Tak Chan, Mei Yuk Choi, Ho Yu Lam, Chung Man Chan, Zhiyong Chen, Hector K Wang, Hoi Ting Leung, Simon Law, Yanmin Huang, Huacan Song, Nikki P Lee
Purpose: Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesis in its native microenvironment. Materials and Methods: In this study, we described two simple and reproducible methods to develop tumor xenograft at the cervical or the abdominal esophagus in nude mice by direct injection of ESCC cells in the esophageal wall...
January 24, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29306222/superiorly-based-nasolabial-island-flap-for-reconstruction-of-the-lateral-lower-eyelid
#15
Sedat Tatar, Yalçın Yontar, Selahattin Özmen
Background/aim: Various flap procedures have been described and used for the lower eyelids; however, the nasolabial flap is rarely employed. We herein aimed to present the clinical results of using the superiorly based nasolabial island flap for repair of surgical defects extending to the lateral lower eyelid. Materials and methods: Nine patients with a mean age of 62 +- 6 years underwent surgery for reconstruction of the lower eyelid.Results: The diagnosis of lesions was nodular basal-cell carcinoma (n = 5), superficial basal-cell carcinoma (n = 1), well-differentiated squamous-cell carcinoma (n = 1), and basosquamous-cell carcinoma (n = 2)...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299509/salivary-fistula-blue-dye-testing-as-part-of-an-algorithm-for-early-diagnosis
#16
Kimberley L Kiong, Ngian Chye Tan, Thakshayeni Skanthakumar, Constance E H Teo, Khee Chee Soo, Hiang Khoon Tan, Elizabeth Roche, Kaisin Yee, N Gopalakrishna Iyer
Objective: Orocutaneous and pharyngocutaneous fistula (OPCF) is a debilitating complication of head and neck surgery for squamous cell carcinoma (SCC), resulting in delayed adjuvant treatment and prolonged hospitalization. As yet, there is no established test that can help in prompt and accurate diagnosis of OPCF. This study aims to determine the accuracy of bedside blue dye testing and its role as part of an algorithm for early diagnosis. We also analyze the risk factors predisposing to OPCF...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29290069/preoperative-prognostic-nutritional-index-predicts-long-term-surgical-outcomes-in-patients-with-esophageal-squamous-cell-carcinoma
#17
Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura, Yoshiko Miyazaki, Takashi Kishi, Yasunari Kawabata
BACKGROUND: The purpose of the present study is to investigate the utility of prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC). METHODS: We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided to set the optimal cutoff value for preoperative PNI levels at 49.2, based on the cancer-specific survival (CSS) and the overall survival (OS) by receiver operating characteristic curve analysis...
December 31, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29249263/reconstructive-methods-in-mohs-micrographic-surgery-in-uruguay-a-bidirectional-descriptive-cohort-analysis
#18
J Navarrete, J Magliano, M Martínez, C Bazzano
BACKGROUND AND OBJECTIVES: The primary goal of Mohs micrographic surgery (MMS) is to completely excise a cancerous lesion and a wide range of reconstructive techniques of varying complexity are used to close the resulting wound. In this study, we performed a descriptive analysis of patients who underwent MMS, with a focus on wound closure methods. MATERIAL AND METHODS: We conducted a bidirectional descriptive cohort analysis of all MMS procedures performed by a single surgeon between November 2013 and April 2016...
December 14, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29233547/the-developing-spectrum-of-gastric-type-cervical-glandular-lesions
#19
REVIEW
Karen L Talia, W Glenn McCluggage
Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. Oncogenic (high-risk) human papillomavirus (HPV) infection is implicated in the development of approximately 90% of all cervical adenocarcinomas. Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. Minimal deviation adenocarcinoma (MDA) of mucinous type (adenoma malignum) is considered an extremely well differentiated variant of GAS and is encompassed within the category of GAS...
February 2018: Pathology
https://www.readbyqxmd.com/read/29207716/expression-of-p16ink4a-protein-in-cervical-intraepithelial-neoplasia-and-invasive-carcinoma-of-uterine-cervix
#20
Vatsala Kishore, Anuradha G Patil
Introduction: Cervical cancer still ranks as the most frequent cancer among women in India. Infection with Human Papilloma Virus (HPV) results in precancerous lesions and invasive cervical cancer. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to upregulation of p16INK4A, a cyclin dependent kinase inhibitor. Therefore, p16INK4A overexpression is a surrogate biomarker of HPV infection making it useful in evaluating HPV associated premalignant and malignant lesions of gynaecological tract...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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