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Autoimmunology

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https://www.readbyqxmd.com/read/27893660/salivary-lactate-dehydrogenase-and-aminotransferases-in-diabetic-patients
#1
Barbara Malicka, Katarzyna Skoskiewicz-Malinowska, Urszula Kaczmarek
Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study was approved by the Bioethics Committee of Wroclaw Medical University (Poland). The study comprised 90 adults of both sexes, aged 21 to 57 years...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27671449/sarcoidosis-associated-aortoesophageal-fistula-multistage-interdisciplinary-surgical-therapy-for-a-rare-and-life-threatening-condition
#2
A Gombert, J Grommes, G Schick, M Binnebösel, C Klink, M J Jacobs, D Kotelis
OBJECTIVE: Aortoesophageal fistulas are rare and life-threatening conditions. Till now, an association between an aortoesophageal fistula and sarcoidoisis has not been reported yet. The aim of this report is to demonstrate a case of aortoesophageal fistula (AEF) secondary to sarcoidosis and its multistage interdisciplinary surgical therapy. CASE REPORT: A 66-year-old male was diagnosed with sarcoidosis in 2014. He has been treated with glucocorticoids since then and no severe health restrictions due the disease had occurred...
September 23, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27513834/alopecia-areata-in-patients-with-inflammatory-bowel-disease-an-overview
#3
REVIEW
Aleksandra Sobolewska-Włodarczyk, Marcin Włodarczyk, Jakub Fichna, Maria Wiśniewska-Jarosińska
Alopecia areata (AA) is one of the most common causes of non-scarring hair loss, which is associated with the premature induction of hair follicle regression. The pathogenesis of AA is unknown, although it is believed that a complicated autoimmune mechanism with Th1 lymphocytes and proinfammatory cytokines, such as IFN-γ, TNF-α, IL-1 and IL-2, may be involved. AA may occur as a single disease entity or coexist with other autoimmunological disorders. In some cases the relationship with infammatory bowel disease (IBD) was observed and the link between molecular pathways and main proinfammatory cytokines in IBD and AA has been suggested...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/27403907/-hygienic-hypothesis-in-immunopathogenesis-of-inflammatory-bowel-disease
#4
REVIEW
Maciej Gonciarz, Dawid Szkudłapski, Aldona Mularczyk, Justyna Smagacz
Over three last decades, it has been noticed that morbidity of immunology-dependent illnesses, like asthma, inflammatory bowel disease or atopic dermatitis, apparently increased. That is the reason to focus on searching and exploring new ideas which could explain etiopathology of those diseases. In etiopathology the role of environmental factors is particularly emphasized. Research indicated the inverse relationship between the frequency of infectious and/ or parasites and autoimmune diseases. It was a leading subject of many studies what allowed to create a hypothesis which explains the phenomenon...
June 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27349037/-neurophysiological-parameters-in-myasthena-gravis-in-children-in-diagnostic-and-therapeutic-view
#5
Sławomir Kroczka, Katarzyna Stasiak, Marek Kaciński
BACKGROUND: Myasthenia gravis (MG) is an autoimmunologic disorder. It is characterized by various clinical symptoms and their dependency upon the exertion and the rest as well. MATERIAL AND METHODS: Between 2002-20014 in the Neurophysiology Laboratory at the Chair of Pediatric and Adolescent Neurology, Jagiellonian University in Krakow, the electrophysiological repetitive nerve stimulation study were performed in 44 children. The clinical picture and positive electrophysiological test were the ground to diagnose MG in 19 of them (12 girls and 7 boys)...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27268924/cardiac-tamponade-unusual-clinical-manifestation-of-undiagnosed-malignant-neoplasm
#6
B Perek, I Tomaszewska, S Stefaniak, I Katynska, M Jemielity
Cardiac tamponade may be the first or predominant symptom of some pathologies but its etiology is not uncommonly unknown on admission to hospital. The purpose of this study was to evaluate the predominant causes of cardiac tamponade in previously healthy patients treated emergently in a single cardiac surgical center. The study involved 81 patients with the mean age of 58.1±16.0 years who underwent emergent subxyphoid pericardiotomy due to cardiac tamponade. Pericardial effusion was analyzed macro- and microscopically...
2016: Neoplasma
https://www.readbyqxmd.com/read/27172995/changes-in-inflammatory-cytokine-networks-in-myasthenia-gravis
#7
Akiyuki Uzawa, Tetsuya Kanai, Naoki Kawaguchi, Fumiko Oda, Keiichi Himuro, Satoshi Kuwabara
Myasthenia gravis (MG) is an autoimmunological inflammatory disorder of the neuromuscular junction. Inflammation could be a key player for understanding the pathogenesis of MG. We measured the serum levels of 24 inflammatory cytokines in 43 patients with anti-acetylcholine receptor antibody-positive MG and 25 healthy controls. In patients with MG, serum levels of a proliferation-inducing ligand (APRIL), IL-19, IL-20, IL-28A and IL-35 were significantly increased as compared with controls (p < 0.05). Among them, IL-20, IL-28A and IL-35 were significantly decreased after treatment (p < 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27117096/wegener-s-granulomatosis-and-pyoderma-gangrenosum-rare-causes-of-facial-ulcerations
#8
REVIEW
Karolina Kędzierska, Krzysztof Sindrewicz, Tomasz Smektała, Magda Wiśniewska, Marek Masiuk, Ewelina Staniszewska, Katarzyna Sporniak-Tutak, Edyta Gołembiewska, Kazimierz Ciechanowski
BACKGROUND: Pyoderma gangrenosum (PG) is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG). The purpose of this article was to compare cases of patients with WG and PG in terms of their clinical course, histopathology, and applied treatment. In both, histopathological features are not fully distinct. Data from microbiological and immunological evaluation and clinical presentation are required to establish the diagnosis...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27088197/-evaluation-of-prevalece-of-plasma-25-oh-d-vitamin-deficiency-in-residents-of-lodz
#9
Małgorzata Godala, Izabela Materek-Kuśmierkiewicz, Dariusz Moczulski, Franciszek Szatko, Ewelina Gaszyńska, Sławomir Tokarski, Jan Kowalski
UNLABELLED: Only scarce data have been published regarding serum vitamin D status in adult population in Poland. Observational studies have suggested relationship between 25(OH)D deficiency and many diseases, such as cardiovascular diseases, autoimmunological diseases or cancers. Still little is known about plasma 25(OH)D deficiency in Polish healthy adults. THE AIM: The aim of the study was to assess plasma 25(OH)D vitamin deficiency in residents of Lodz. MATERIALS AND METHODS: The study included 326 residents of Lodz, 156 men and 170 women, aged 30-65 years (mean 57,25±8,24 years)...
March 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26983869/liver-transplantation-in-patients-with-cryptogenic-cirrhosis-provides-excellent-long-term-outcome
#10
Łukasz Masior, Michał Grąt, Maciej Krasnodębski, Waldemar Patkowski, Marek Krawczyk
BACKGROUND: Cryptogenic cirrhosis (CC) is an indication for liver transplantation in 5-9% of recipients. Diagnosis is made when other diagnostic possibilities have been ruled out. The aim of this study was to present long-term outcomes of liver transplantation for CC. MATERIAL AND METHODS: There have been 1367 liver transplantations performed during the years 1994-2013 in the Department of General, Transplant and Liver Surgery at the Medical University of Warsaw...
2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/26943356/differences-in-gene-gene-interactions-in-graves-disease-patients-stratified-by-age-of-onset
#11
Beata Jurecka-Lubieniecka, Tomasz Bednarczuk, Rafal Ploski, Jolanta Krajewska, Dorota Kula, Malgorzata Kowalska, Andrzej Tukiendorf, Zofia Kolosza, Barbara Jarzab
BACKGROUND: Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. Each gene exerts limited effects on the development of autoimmune disease (OR = 1.2-1.5). An epidemiological study revealed that nearly 70% of the risk of developing inherited autoimmunological thyroid diseases (AITD) is the result of gene interactions. In the present study, we analyzed the effects of the interactions of multiple loci on the genetic predisposition to GD...
2016: PloS One
https://www.readbyqxmd.com/read/26900306/association-between-bacterial-infection-and-peripheral-vascular-disease-a-review
#12
REVIEW
Jacek Budzyński, Joanna Wiśniewska, Marek Ciecierski, Anna Kędzia
There are an increasing number of data showing a clinically important association between bacterial infection and peripheral artery disease (PAD). Bacteria suspected of being involved in PAD pathogenesis are: periodontal bacteria, gut microbiota, Helicobacter pylori, and Chlamydia pneumoniae. Infectious agents may be involved in the pathogenesis of atherosclerosis via activation of a systemic or local host immunological response to contamination of extravascular tissues or the vascular wall, respectively. A systemic immunological reaction may damage vascular walls in the course of autoimmunological cross-reactions between anti-pathogen antibodies and host vascular antigens (immunological mimicry), pathogen burden mechanisms (nonspecific activation of inflammatory processes in the vascular wall), and neuroendocrine-immune cross-talk...
March 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/26891441/-mitoxantrone-role-in-treatment-of-primary-progressive-multiple-sclerosis
#13
REVIEW
Żanna Pastuszak, Adam Stępień, Kazimierz Tomczykiewicz, Renata Piusińska-Macoch, Marta Durka-Kęsy
Multiple sclerosis is a chronic, autoimmunological disease of central nervous system in which axonal damage in brain and spinal cord is observed. It is second most common cause of disability in young adults in West Europe and North America after injuries. There is 2.5 million people suffered from multiple sclerosis worldwide. The worse prognosis is connected with primary progressive MS in which recovery after first symptoms of central nervous system damage isn't observed. That subtype of disease is seen in case of 10-20% people with MS...
January 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26860322/vitamin-d-and-its-relevance-in-the-etiopathogenesis-of-oral-cavity-diseases
#14
REVIEW
Zuzannna Ślebioda, Elżbieta Szponar, Barbara Dorocka-Bobkowska
Vitamin D belongs to a group of fat-soluble secosteroids which assume many roles in the human organism. In humans the most important forms are vitamin D3 and vitamin D2. Their primary function is the regulation of the calcium and phosphorus balance, which promote the growth of healthy bony tissue. Studies over the past few years have revealed a much wider role of vitamin D involving the aging processes, carcinogenesis, the carbohydrate balance as well as the effects on the course of various infections. In this paper we discuss the basic functions of vitamin D in the human body and the mechanisms of its activity and we summarize recent reports on the impact of vitamin D on the oral cavity with a special emphasis on autoimmunologic diseases, including: recurrent aphthous stomatitis, Behçet syndrome and Sjögren syndrome...
October 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/26445249/-thromboangiitis-obliterans-buerger-s-disease-update-2015
#15
Peter Klein-Weigel, Theresa Sophie Volz, Jutta Richter
Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors...
October 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26366642/-imaging-of-the-lacrimal-gland-and-the-lacrimal-drainage-system
#16
REVIEW
C C Pieper, D Thomas
A large number of different neoplastic, infective and autoimmunologic diseases can affect the lacrimal gland. Thorough imaging examinations can help to characterize lesions to narrow down possible differential diagnoses. Diseases of the lacrimal drainage system, especially obstructions with constant epiphora are often very irritating for the patients. Imaging examinations can assist in selecting the adequate therapy in interdisciplinary consensus. Moreover, interventional-radiological therapy (e. g. balloon-dacryocystoplasty) is an attractive minimally-invasive treatment alternative...
September 2015: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/26362130/-mid-dermal-elastolysis-after-insertion-of-a-pacemaker
#17
D Kottler, A Lefèvre, B Balme, V Martin-Bourret, D Zaharia, F Skowron
BACKGROUND: Mid-dermal elastolysis (MDE) is a rare acquired disease of elastic tissue histologically characterized by focal loss of elastic fibres within the mid-dermis. While the mechanisms leading to MDE remain unknown, increased degradation of elastic fibres may be involved. Many factors potentially triggering such degradation have been suggested. PATIENTS AND METHODS: A 58-year-old man consulted for an asymptomatic reticulated eruption that began in the area of a pacemaker implanted six weeks earlier...
November 2015: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/26328025/from-the-stomach-to-other-organs-helicobacter-pylori-and-the-liver
#18
REVIEW
Marek Waluga, Michał Kukla, Michał Żorniak, Agata Bacik, Rafał Kotulski
Many recent studies have examined the importance of Helicobacter pylori (H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis...
August 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26298799/-ipilimumab-induced-colitis-a-new-challenge-for-gastroenterologists
#19
Francisco Mesonero, Antonio López-Sanromán, Ainhoa Madariaga, Ainara Soria
Many drugs can produce enterocolitis and they should always be included in the differential diagnosis of this clinical picture. Entities such as antibiotic-associated colitis and neutropenic colitis have been known for some time and recently a new type of drug-induced colitis has emerged due to monoclonal antibodies. Ipimumab is a humanized monoclonal antibody against the CTLA4 molecule that is involved in the maturation and regulation of T lymphocyte activation. This drug causes immune activation and has an immune-mediated antitumor effect with excellent results in tumours such as melanoma...
March 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/26216115/effect-of-oral-administration-of-pig-spinal-cord-hydrolysate-on-clinical-and-histopathological-symptoms-of-experimental-allergic-encephalomyelitis-in-rats
#20
Kaja Kasarełło, Roman Gadamski, Piotr Piotrowski, Katarzyna Kurzepa, Barbara Kwiatkowska-Patzer, Andrzej W Lipkowski
Oral tolerance is the natural occurring phenomenon of a decreased immune response to previously fed antigens, which prevents induction of a response to dietary antigens. One of the mechanisms is deletion of T lymphocytes reactive to the fed antigen. Knowing that phenomenon, it seems appropriate to engage this mechanism for treatment of autoimmune diseases. Multiple sclerosis (MS) is an autoimmunological disease which causes neurological impairment in humans. Autoreactive T lymphocytes migrate through the open blood-brain barrier into the central nervous system (CNS), where they recognize myelin antigens as foreign, and induce an inflammatory response against the myelin sheath, which causes demyelination and even axonal loss...
2015: Folia Neuropathologica
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