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https://www.readbyqxmd.com/read/27922482/evolution-of-quality-assurance-for-clinical-immunohistochemistry-in-the-era-of-precision-medicine-part-1-fit-for-purpose-approach-to-classification-of-clinical-immunohistochemistry-biomarkers
#1
Carol C Cheung, Corrado D'Arrigo, Manfred Dietel, Glenn D Francis, C Blake Gilks, Jacqueline A Hall, Jason L Hornick, Merdol Ibrahim, Antonio Marchetti, Keith Miller, J Han van Krieken, Soren Nielsen, Paul E Swanson, Clive R Taylor, Mogens Vyberg, Xiaoge Zhou, Emina E Torlakovic
Technical progress in immunohistochemistry (IHC) as well as the increased utility of IHC for biomarker testing in precision medicine avails us of the opportunity to reassess clinical IHC as a laboratory test and its proper characterization as a special type of immunoassay. IHC, as used in current clinical applications, is a descriptive, qualitative, cell-based, usually nonlinear, in situ protein immunoassay, for which the readout of the results is principally performed by pathologists rather than by the instruments on which the immunoassay is performed...
January 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27889851/effect-of-cow-colostrum-on-the-performance-and-survival-rate-of-local-newborn-piglets-in-benin-republic
#2
Aristide Mahoutin Agbokounou, Gbênangnon Serge Ahounou, Issaka Youssao Abdou Karim, Guy Apollinaire Mensah, Bénoît Koutinhouin, Jean-Luc Hornick
The effect of bovine colostrum, including its thermally labile compounds, on the survival and growth performance of local breed piglets reared by their mother, in Benin, was evaluated over a 49-day trial. Three groups of 16 piglets, stemming from two primiparous sows belonging to a unique traditional farm, were respectively fed for the first 48 h of life with either bovine colostrum heated to 85 °C for 30 min, or thawed bovine colostrum, or colostrum from the mother. Thereafter, the animals that received bovine colostrum turned back to their mother...
November 26, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27874193/alk-oncoproteins-in-atypical-inflammatory-myofibroblastic-tumours-novel-rrbp1-alk-fusions-in-epithelioid-inflammatory-myofibroblastic-sarcoma
#3
Jen-Chieh Lee, Chien-Feng Li, Hsuan-Ying Huang, Mei-Jun Zhu, Adrián Mariño-Enríquez, Chung-Ta Lee, Wen-Bin Ou, Jason L Hornick, Jonathan A Fletcher
ALK oncogenic activation mechanisms were characterized in four conventional spindle-cell inflammatory myofibroblastic tumours (IMT) and five atypical IMT, each of which had ALK genomic perturbations. Constitutively activated ALK oncoproteins were purified by ALK immunoprecipitation and electrophoresis, and were characterized by mass spectrometry. The four conventional IMT had TPM3/4-ALK fusions (two cases) or DCTN1-ALK fusions (two cases), whereas two atypical spindle-cell IMT had TFG-ALK and TPM3-ALK fusion in one case each, and three epithelioid inflammatory myofibroblastic sarcomas had RANBP2-ALK fusions in two cases, and a novel RRBP1-ALK fusion in one case...
November 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27852700/genomic-evolution-after-chemoradiotherapy-in-anal-squamous-cell-carcinoma
#4
Kent W Mouw, James M Cleary, Brendan Reardon, Jonathan Pike, Lior Z Braunstein, Jaegil Kim, Ali Amin-Mansour, Diana Miao, Alexis Damish, Joanna Chin, Patrick A Ott, Charles S Fuchs, Neil E Martin, Gad Getz, Scott Carter, Harvey Mamon, Jason L Hornick, Eliezer Van Allen, Alan D D'Andrea
PURPOSE: Squamous cell carcinoma of the anal canal (ASCC) accounts for 2-4% of gastrointestinal (GI) malignancies in the US and is increasing in incidence; however, genomic features of ASCC are incompletely characterized. Primary treatment of ASCC involves concurrent chemotherapy and radiation (CRT), but the mutational landscape of resistance to CRT is unknown. Here, we aim to compare mutational features of ASCC in the pre- and post-CRT setting. EXPERIMENTAL DESIGN: We perform whole exome sequencing of primary (n=31) and recurrent (n=31) ASCCs and correlate findings with clinical data...
November 16, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27843553/diabetes-as-an-increasingly-common-comorbidity-among-patient-hospitalizations-for-tuberculosis-in-the-usa
#5
Roula S Zahr, Ryan A Peterson, Linnea A Polgreen, Joseph E Cavanaugh, Douglas B Hornick, Kevin L Winthrop, Philip M Polgreen
OBJECTIVE: Diabetes is a risk factor for active tuberculosis (TB). The purpose of this paper was to estimate the risk of hospitalization for TB with and without a secondary diagnosis of diabetes in groups with different ethnic backgrounds. RESEARCH DESIGN AND METHODS: We used the Nationwide Inpatient Sample from 1998 to 2011, identifying all patients with a primary diagnosis of TB and/or a secondary diagnosis of diabetes (type 1 or type 2) or HIV. Next, we performed logistic regression to investigate the association of diabetes status, HIV status, and race (and the interaction of diabetes and race) with the risk of hospitalization with a primary diagnosis of TB...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27779193/nlrp12-mutation-causes-c57bl-6j-strain-specific-defect-in-neutrophil-recruitment
#6
Tyler K Ulland, Nidhi Jain, Emma E Hornick, Eric I Elliott, Gwendolyn M Clay, Jeffrey J Sadler, Kathleen A M Mills, Ann M Janowski, A Paige Davis Volk, Kai Wang, Kevin L Legge, Lokesh Gakhar, Mohammed Bourdi, Polly J Ferguson, Mary E Wilson, Suzanne L Cassel, Fayyaz S Sutterwala
The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a missense mutation in Nlrp12 in C57BL/6J mice. Both C57BL/6J and NLRP12-deficient mice have increased susceptibility to bacterial infection that correlates with defective neutrophil migration. C57BL/6J and NLRP12-deficient macrophages have impaired CXCL1 production and the neutrophil defect observed in C57BL/6J and NLRP12-deficient mice is rescued by restoration of macrophage NLRP12...
October 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27777599/frailty-has-a-stronger-association-with-inflammation-than-age-in-older-veterans
#7
P Van Epps, D Oswald, P A Higgins, T R Hornick, H Aung, R E Banks, B M Wilson, C Burant, S Graventstein, D H Canaday
BACKGROUND: Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the relative relationship of age and frailty on inflammation and thrombosis in older veterans. RESULTS: We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts: non-frail, pre-frail and frail based on the Fried phenotype of frailty...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27762594/metastatic-patterns-of-solitary-fibrous-tumors-a-single-institution-experience
#8
Ailbhe C O'Neill, Sree Harsha Tirumani, Woo S Do, Abhishek R Keraliya, Jason L Hornick, Atul B Shinagare, Nikhil H Ramaiya
OBJECTIVE: The objective of our study was to evaluate the metastatic patterns and imaging features of solitary fibrous tumors (SFTs). MATERIALS AND METHODS: This retrospective study included 139 patients with pathologically proven SFT, 49 of whom developed metastases. Electronic medical records and all available images were reviewed to record the pattern and imaging appearances of metastatic disease, and comparisons of thoracic SFTs and extrathoracic SFTs were also performed...
October 20, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27720760/trim32-deficiency-enhances-th2-immunity-and-predisposes-to-features-of-atopic-dermatitis
#9
Yuangang Liu, Zhiping Wang, Rachel De La Torre, Ashley Barling, Takahiro Tsujikawa, Noah Hornick, Jon Hanifin, Eric Simpson, Yun Wang, Emily Swanzey, Aaron Wortham, Hao Ding, Lisa M Coussens, Molly Kulesz-Martin
Altered innate immunity is a feature of certain skin inflammatory diseases such as psoriasis and atopic dermatitis (AD). In this study, we provide evidence that deficiency in Trim32 (a tripartite motif [TRIM] protein with innate antiviral activity) contributes to a T helper type 2 biased response and predisposes to features of AD in mice. On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knockout mice displayed compromised psoriasiform phenotypes and defective T helper type 17 response...
October 5, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27645897/beyond-gastric-adenocarcinoma-multimodality-assessment-of-common-and-uncommon-gastric-neoplasms
#10
Danielle M Richman, Sree Harsha Tirumani, Jason L Hornick, Charles S Fuchs, Stephanie Howard, Katherine Krajewski, Nikhil Ramaiya, Michael Rosenthal
Despite advances in molecular biology, imaging, and treatment, gastric neoplasms remain a significant cause of morbidity and mortality; gastric adenocarcinoma is the fifth most common malignancy and third most common cause of death worldwide (Brenner et al., Methods Mol Biol 472:467-477, 2009; Howson et al. Epidemiol Rev 8:1-27, 1986; Roder, Gastric Cancer 5(Suppl 1):5-11, 2002; Ferlay et al., GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. International Agency for Research on Cancer, 2013)...
September 19, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27618325/current-concepts-in-the-molecular-genetics-and-management-of-thyroid-cancer-an-update-for-radiologists
#11
Tatiana Kelil, Abhishek R Keraliya, Stephanie A Howard, Katherine M Krajewski, Marta Braschi-Amirfarzan, Jason L Hornick, Nikhil H Ramaiya, Sree Harsha Tirumani
Substantial improvement in the understanding of the oncogenic pathways in thyroid cancer has led to identification of specific molecular alterations, including mutations of BRAF and RET in papillary thyroid cancer, mutation of RAS and rearrangement of PPARG in follicular thyroid cancer, mutation of RET in medullary thyroid cancer, and mutations of TP53 and in the phosphatidylinositol 3'-kinase (PI3K)/AKT1 pathway in anaplastic thyroid cancer. Ultrasonography (US) and US-guided biopsy remain cornerstones in the initial workup of thyroid cancer...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27617861/nlrc4-suppresses-melanoma-tumor-progression-independently-of-inflammasome-activation
#12
Ann M Janowski, Oscar R Colegio, Emma E Hornick, Jennifer M McNiff, Matthew D Martin, Vladimir P Badovinac, Lyse A Norian, Weizhou Zhang, Suzanne L Cassel, Fayyaz S Sutterwala
Members of the NLR family can assemble inflammasome complexes with the adaptor protein ASC and caspase-1 that result in the activation of caspase-1 and the release of IL-1β and IL-18. Although the NLRC4 inflammasome is known to have a protective role in tumorigenesis, there is an increased appreciation for the inflammasome-independent actions of NLRC4. Here, we utilized a syngeneic subcutaneous murine model of B16F10 melanoma to explore the role of NLRC4 in tumor suppression. We found that NLRC4-deficient mice exhibited enhanced tumor growth that was independent of the inflammasome components ASC and caspase-1...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27601730/aml-suppresses-hematopoiesis-by-releasing-exosomes-that-contain-micrornas-targeting-c-myb
#13
Noah I Hornick, Ben Doron, Sherif Abdelhamed, Jianya Huan, Christina A Harrington, Rongkun Shen, Xiaolu A Cambronne, Santhosh Chakkaramakkil Verghese, Peter Kurre
Exosomes are paracrine regulators of the tumor microenvironment and contain complex cargo. We previously reported that exosomes released from acute myeloid leukemia (AML) cells can suppress residual hematopoietic stem and progenitor cell (HSPC) function indirectly through stromal reprogramming of niche retention factors. We found that the systemic loss of hematopoietic function is also in part a consequence of AML exosome-directed microRNA (miRNA) trafficking to HSPCs. Exosomes isolated from cultured AML or the plasma from mice bearing AML xenografts exhibited enrichment of miR-150 and miR-155...
September 6, 2016: Science Signaling
https://www.readbyqxmd.com/read/27565591/a-telephone-call-1-week-after-hospitalization-can-identify-risk-factors-for-vascular-surgery-readmission
#14
John R Hornick, Joshua A Balderman, Ronnie Eugea, Luis A Sanchez, Mohamed A Zayed
OBJECTIVE: Compared with other populations, patients who undergo vascular surgery have higher 30-day hospital readmission rates of up to 25%. Postdischarge telephone call assessments have demonstrated utility in patients with significant medical comorbidities and traditionally high readmission rates. Therefore, we hypothesized that a 1-week postdischarge telephone call evaluation can identify risk factors for readmission among vascular surgery patients. METHODS: Patients who underwent a vascular surgery procedure during a 1-year period by a single vascular surgeon at one hospital received a postdischarge telephone call questionnaire to review postoperative pain, surgical site, constitutional symptoms, and follow-up arrangement...
September 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27556954/universal-screening-for-mismatch-repair-deficiency-in-endometrial-cancers-to-identify-patients-with-lynch-syndrome-and-lynch-like-syndrome
#15
Jaclyn C Watkins, Eric J Yang, Michael G Muto, Colleen M Feltmate, Ross S Berkowitz, Neil S Horowitz, Sapna Syngal, Matthew B Yurgelun, Anu Chittenden, Jason L Hornick, Christopher P Crum, Lynette M Sholl, Brooke E Howitt
Although consensus has yet to be reached on universal mismatch-repair (MMR) protein immunohistochemical (IHC) screening for Lynch syndrome (LS) in endometrial cancer (EC), an increasing number of institutions have adopted universal screening protocols similar to those used for colorectal carcinoma. Here we describe our institution's experience with a prospective universal screening protocol in which all ECs resected over a period of 19 months (n=242) were screened for MLH1, PMS2, MSH2, and MSH6 deficiencies using IHC, followed by MLH1 promoter methylation testing when appropriate...
August 23, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27525979/influence-of-ocean-acidification-on-a-natural-winter-to-summer-plankton-succession-first-insights-from-a-long-term-mesocosm-study-draw-attention-to-periods-of-low-nutrient-concentrations
#16
Lennart T Bach, Jan Taucher, Tim Boxhammer, Andrea Ludwig, Eric P Achterberg, María Algueró-Muñiz, Leif G Anderson, Jessica Bellworthy, Jan Büdenbender, Jan Czerny, Ylva Ericson, Mario Esposito, Matthias Fischer, Mathias Haunost, Dana Hellemann, Henriette G Horn, Thomas Hornick, Jana Meyer, Michael Sswat, Maren Zark, Ulf Riebesell
Every year, the oceans absorb about 30% of anthropogenic carbon dioxide (CO2) leading to a re-equilibration of the marine carbonate system and decreasing seawater pH. Today, there is increasing awareness that these changes-summarized by the term ocean acidification (OA)-could differentially affect the competitive ability of marine organisms, thereby provoking a restructuring of marine ecosystems and biogeochemical element cycles. In winter 2013, we deployed ten pelagic mesocosms in the Gullmar Fjord at the Swedish west coast in order to study the effect of OA on plankton ecology and biogeochemistry under close to natural conditions...
2016: PloS One
https://www.readbyqxmd.com/read/27523970/molecular-evaluation-of-colorectal-adenocarcinoma-current-practice-and-emerging-concepts
#17
REVIEW
Jonathan A Nowak, Jason L Hornick
Molecular testing in colorectal cancer helps to address multiple clinical needs. Evaluating the mismatch repair pathway status is the most common use for molecular diagnostics and this testing provides prognostic information, guides therapeutic decisions and helps identify Lynch syndrome patients. For patients with metastatic colorectal cancer, testing for activating mutations in downstream components of the EGFR signaling pathway can identify patients who will benefit from anti-EGFR therapy. Emerging molecular tests for colorectal cancer will help further refine patient selection for targeted therapies and may provide new options for monitoring disease recurrence and the development of treatment resistance...
September 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27491879/reproductive-age-associated-fibrosis-in-the-stroma-of-the-mammalian-ovary
#18
Shawn M Briley, Susmita Jasti, Jennifer M McCracken, Jessica E Hornick, Barbara Fegley, Michele T Pritchard, Francesca E Duncan
Under normal physiological conditions, tissue remodeling in response to injury leads to tissue regeneration without permanent damage. However, if homeostasis between synthesis and degradation of extracellular matrix (ECM) components is altered, fibrosis - or the excess accumulation of ECM - can disrupt tissue architecture and function. Several organs, including the heart, lung and kidney, exhibit age-associated fibrosis. Here we investigated whether fibrosis underlies aging in the ovary - an organ that ages chronologically before other organs...
September 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27444171/s-100-protein-expressing-spindle-cells-in-spindle-cell-lipoma-a-diagnostic-pitfall
#19
T Mentzel, A Rütten, M Hantschke, J L Hornick, T Brenn
Spindle cell lipoma represents a distinct clinicopathological entity and is related to cellular angiofibroma and mammary-type myofibroblastoma. Spindle cell lipomas are composed of mature lipogenic cells and a variable number of CD34-positive spindle cells that show loss of retinoblastoma protein expression. Spindle cell lipomas occasionally express S-100 protein. We studied one case of purely dermal spindle cell lipoma and four cases of classical subcutaneous spindle cell lipoma arising in one female and four male patients (age ranged from 55 to 69 years)...
October 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27443513/evaluation-of-etv4-and-wt1-expression-in-cic-rearranged-sarcomas-and-histologic-mimics
#20
Yin P Hung, Christopher Dm Fletcher, Jason L Hornick
A distinct subset of round cell sarcomas harbors capicua transcriptional repressor (CIC) rearrangement. Diagnosing these sarcomas can be difficult owing to their resemblance to Ewing sarcoma and other 'small round blue cell tumors'; molecular techniques are generally required. Recent gene expression studies of CIC-rearranged sarcomas identified the upregulation of ETV4. We assessed the sensitivity and specificity of ETV4 and WT1 immunohistochemistry for CIC-rearranged sarcoma. We evaluated whole-tissue sections from 40 CIC-rearranged sarcomas, 40 Ewing sarcomas, 4 BCOR-CCNB3 sarcomas, 6 unclassified round cell sarcomas, and 150 histologic mimics...
July 22, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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