Yue Wu, Zhijie Yue, Qiguang Wang, Qiang Lv, Huan Liu, Yungang Bai, Shaohua Li, Manjiang Xie, Junxiang Bao, Jin Ma, Zhongchao Wang, Xianyang Zhu
Previous studies have demonstrated cardiac and vascular remodeling induced by microgravity exposure. Yet, as the most important branch of vasculatures circulating the heart, the coronary artery has been seldomly studied about its adaptations under microgravity conditions. Large-conductance Ca2+ -activated potassium channel (BKCa ) and the Ras homolog family member A (RhoA)/Rho kinase (ROCK) pathway play key roles in control of vascular tone and mediation of microgravity-induced vascular adjustments. Therefore, we investigated the adaptation of coronary vasoreactivity to simulated microgravity and the role of BKCa and the RhoA/ROCK pathway in it...
December 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology