keyword
MENU ▼
Read by QxMD icon Read
search

pestis

keyword
https://www.readbyqxmd.com/read/29159477/factors-influencing-uptake-of-sylvatic-plague-vaccine-baits-by-prairie-dogs
#1
Rachel C Abbott, Robin E Russell, Katherine L D Richgels, Daniel W Tripp, Marc R Matchett, Dean E Biggins, Tonie E Rocke
Sylvatic plague vaccine (SPV) is a virally vectored bait-delivered vaccine expressing Yersinia pestis antigens that can protect prairie dogs (Cynomys spp.) from plague and has potential utility as a management tool. In a large-scale 3-year field trial, SPV-laden baits containing the biomarker rhodamine B (used to determine bait consumption) were distributed annually at a rate of approximately 100-125 baits/hectare along transects at 58 plots encompassing the geographic ranges of four species of prairie dogs...
November 20, 2017: EcoHealth
https://www.readbyqxmd.com/read/29155827/the-asian-house-shrew-suncus-murinus-as-a-reservoir-and-source-of-human-outbreaks-of-plague-in-madagascar
#2
Soanandrasana Rahelinirina, Minoarisoa Rajerison, Sandra Telfer, Cyril Savin, Elisabeth Carniel, Jean-Marc Duplantier
Identifying key reservoirs for zoonoses is crucial for understanding variation in incidence. Plague re-emerged in Mahajanga, Madagascar in the 1990s but there has been no confirmed case since 1999. Here we combine ecological and genetic data, from during and after the epidemics, with experimental infections to examine the role of the shrew Suncus murinus in the plague epidemiological cycle. The predominance of S. murinus captures during the epidemics, their carriage of the flea vector and their infection with Yersinia pestis suggest they played an important role in the maintenance and transmission of plague...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29141768/rat-fall-surveillance-coupled-with-vector-control-and-community-education-as-a-plague-prevention-strategy-in-the-west-nile-region-uganda
#3
Karen A Boegler, Linda A Atiku, Russell E Enscore, Titus Apangu, Joseph Tendo Mpanga, Sarah Acayo, John Kaggwa, Paul S Mead, Brook M Yockey, Kiersten J Kugeler, Martin E Schriefer, Kalanthe Horiuchi, Kenneth L Gage, Rebecca J Eisen
Plague, primarily a disease of rodents, is most frequently transmitted by fleas and causes potentially fatal infections in humans. In Uganda, plague is endemic to the West Nile region. Primary prevention for plague includes control of rodent hosts or flea vectors, but targeting these efforts is difficult given the sporadic nature of plague epizootics in the region and limited resource availability. Here, we present a community-based strategy to detect and report rodent deaths (rat fall), an early sign of epizootics...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141705/phenotypic-and-molecular-genetic-characteristics-of-yersinia-pestis-at-an-emerging-natural-plague-focus-junggar-basin-china
#4
Yujiang Zhang, Tao Luo, Chao Yang, Xihong Yue, Rong Guo, Xinhui Wang, Mingde Buren, Yuqin Song, Ruifu Yang, Hanli Cao, Yujun Cui, Xiang Dai
The 15th natural plague focus in China, the Junggar Basin plague focus, is located near an important communication route connecting China and Central Asia and was discovered after 2005. To characterize the phenotypic and genetic diversity of the Yersinia pestis population in this newly established focus, we collected 25 Y. pestis strains from six counties across Junggar Basin in 2005-2006, and determined their biochemical features and genotypes based on multiple-locus variable number of tandem repeats analysis and clustered regularly interspaced short palindromic repeats analysis...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29136087/the-utility-and-perspectives-of-ngs-based-methods-in-bsl-3-and-bsl-4-laboratory-sequencing-and-analysis-strategies
#5
Tomasz Wolkowicz
Modern diagnostics is in general based on molecular biology methods. Nowadays sequencing-based methods, especially whole genome sequencing, are becoming increasingly important. Implementation of such methods into routine diagnostic of highly dangerous pathogens, like Bacillus anthracis, Francisella tularensis, Yersinia pestis, Ebola virus, MERS, Lassa virus etc. would be very helpful. The best diagnostic strategy would be the metagenomic sequencing directly from the clinical sample. Implementation of majority of currently available WGS platforms inside the BSL-3 or 4 laboratory is impractical because of the size of the equipment and time consuming wet lab part (e...
November 10, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29129538/pneumonia-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#6
REVIEW
Mohd Basri Mat Nor, Guy A Richards, Steve McGloughlin, Pravin R Amin
The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
November 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29128818/comparison-of-2d-and-3d-neural-induction-methods-for-the-generation-of-neural-progenitor-cells-from-human-induced-pluripotent-stem-cells
#7
Abinaya Chandrasekaran, Hasan X Avci, Anna Ochalek, Lone N Rösingh, Kinga Molnár, Lajos László, Tamás Bellák, Annamária Téglási, Krisztina Pesti, Arpad Mike, Phetcharat Phanthong, Orsolya Bíró, Vanessa Hall, Narisorn Kitiyanant, Karl-Heinz Krause, Julianna Kobolák, András Dinnyés
Neural progenitor cells (NPCs) from human induced pluripotent stem cells (hiPSCs) are frequently induced using 3D culture methodologies however, it is unknown whether spheroid-based (3D) neural induction is actually superior to monolayer (2D) neural induction. Our aim was to compare the efficiency of 2D induction with 3D induction method in their ability to generate NPCs, and subsequently neurons and astrocytes. Neural differentiation was analysed at the protein level qualitatively by immunocytochemistry and quantitatively by flow cytometry for NPC (SOX1, PAX6, NESTIN), neuronal (MAP2, TUBB3), cortical layer (TBR1, CUX1) and glial markers (SOX9, GFAP, AQP4)...
October 14, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29114402/comparative-scaffolding-and-gap-filling-of-ancient-bacterial-genomes-applied-to-two-ancient-yersinia-pestis-genomes
#8
Nina Luhmann, Daniel Doerr, Cedric Chauve
Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for several dramatic historical pandemics. Progress in ancient DNA (aDNA) sequencing rendered possible the sequencing of whole genomes of important human pathogens, including the ancient Y. pestis strains responsible for outbreaks of the bubonic plague in London in the 14th century and in Marseille in the 18th century, among others. However, aDNA sequencing data are still characterized by short reads and non-uniform coverage, so assembling ancient pathogen genomes remains challenging and often prevents a detailed study of genome rearrangements...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29095164/the-crystal-structure-of-the-yersinia-pestis-iron-chaperone-yiua-reveals-a-basic-triad-binding-motif-for-the-chelated-metal
#9
Christopher D Radka, Dongquan Chen, Lawrence J DeLucas, Stephen G Aller
Biological chelating molecules called siderophores are used to sequester iron and maintain its ferric state. Bacterial substrate-binding proteins (SBPs) bind iron-siderophore complexes and deliver these complexes to ATP-binding cassette (ABC) transporters for import into the cytoplasm, where the iron can be transferred from the siderophore to catalytic enzymes. In Yersinia pestis, the causative agent of plague, the Yersinia iron-uptake (Yiu) ABC transporter has been shown to improve iron acquisition under iron-chelated conditions...
November 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29090192/identification-of-new-virulence-factors-and-vaccine-candidates-for-yersinia-pestis
#10
Jourdan A Andersson, Jian Sha, Tatiana E Erova, Eric C Fitts, Duraisamy Ponnusamy, Elena V Kozlova, Michelle L Kirtley, Ashok K Chopra
Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis using an in vivo signature-tagged mutagenesis (STM) screening approach. From this screen, the role of rbsA, which encodes an ATP-binding protein of ribose transport system, and vasK, an essential component of the type VI secretion system (T6SS), were evaluated in mouse models of plague and confirmed to be important during Y. pestis infection. However, many of the identified genes from the screen remained uncharacterized...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29073248/yersinia-pestis-strains-of-ancient-phylogenetic-branch-0-ant-are-widely-spread-in-the-high-mountain-plague-foci-of-kyrgyzstan
#11
Galina A Eroshenko, Nikita Yu Nosov, Yaroslav M Krasnov, Yevgeny G Oglodin, Lyubov M Kukleva, Natalia P Guseva, Alexander A Kuznetsov, Sabyrzhan T Abdikarimov, Aigul K Dzhaparova, Vladimir V Kutyrev
Fifty six Yersinia pestis strains, isolated over the period of more than 50 years in three high-mountain foci of Kyrgyzstan (Tien Shan, Alai, and Talas), have been characterized by means of PCR and single nucleotide polymorphism (SNP) typing methods. Seven of these strains were also characterized by means of whole genome sequencing and genome-wide SNP phylogenetic analysis. It was found that forty two strains belong to 0.ANT2, 0.ANT3 and 0.ANT5 phylogenetic branches. From these, strains of 0.ANT2 and 0.ANT3 branches were earlier detected in China only, whereas 0...
2017: PloS One
https://www.readbyqxmd.com/read/29070654/plague-recognition-treatment-and-prevention
#12
Ruifu Yang
Plague is caused by Yersinia pestis and not commonly encountered in clinics, although natural plague foci are widely distributed around the world. Y. pestis has been listed as a Category A bioterrorism agent. A neglected diagnosis will cause severe consequences. Therefore, this minireview briefly introduces the current understanding on Y. pestis, and then focuses on practical aspects of plague, including clinical manifestations, diagnosis, treatment and prevention, to alert clinicians about this notorious disease...
October 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29060987/-epidemics-and-risk-factors-of-plague-in-junggar-basin-xinjiang-uygur-autonomous-region-2007-2016
#13
Y J Zhang, C Wang, T Luo, R Guo, W W Meng
Objective: To explore the epidemic situation of animal plague in Junggar Basin natural plague foci. Methods: Data on epidemics of plague and on population involved, as well as results on antibodies and pathogens, were analyzed. Samples on animals and vectors were collected from 18 counties in Junggar Basin plague natural foci between 2007 and 2016. Results: The density of Rhombomys (R.) opimus was temporally fluctuant, from 2.1/hm(2) to 22.6/hm(2) respectively. However, the spatial distribution appeared asymmetrical, with the highest seen in Kelamayi and Wumuqi-midong counties, as 14...
October 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29059012/mammalian-hosts-vectors-and-bacterial-pathogens-in-communities-with-and-without-black-tailed-prairie-dogs-cynomys-ludovicianus-in-northwestern-mexico
#14
Carinthia Zapata-Valdés, Rafael Avila-Flores, Kenneth Gage, Jennifer Holmes, John Montenierri, Michael Kosoy, Gerardo Suzán
The presence of keystone species can influence disease dynamics through changes in species diversity and composition of vector and host communities. In this study, we compared 1) the diversity of small mammals; 2) the prevalence, abundance, and intensity of arthropod vectors; and 3) the prevalence of Yersinia pestis, Francisella tularensis, and Bartonella spp. in vectors, between two grassland communities of northern Sonora, Mexico, one with (La Mesa [LM]) and one without (Los Fresnos [LF]) black-tailed prairie dogs (Cynomys ludovicianus)...
October 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29037578/a-phase-i-safety-and-immunogenicity-dose-escalation-trial-of-plague-vaccine-flagellin-f1-v-in-healthy-adult-volunteers-dmid-08-0066
#15
Sharon E Frey, Kathleen Lottenbach, Irene Graham, Edwin Anderson, Kanwaldeep Bajwa, Ryan C May, Steven B Mizel, Aaron Graff, Robert B Belshe
INTRODUCTION: Intentional aerosolization of Yersinia pestis may result in pneumonic plague which is highly fatal if not treated early. METHODS: We conducted a phase 1 randomized, double blind (within each group), placebo controlled, dose escalation trial to evaluate a plague vaccine, Flagellin/F1/V, in healthy adults aged 8 through 45years. Vaccine was administered intramuscularly on Days 0 and 28 at a dose of 1, 3, 6 or 10mcg. Subjects were observed for 4h after vaccination for cytokine release syndrome...
October 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#16
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 12, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29030266/plasmid-mediated-doxycycline-resistance-in-a-yersinia-pestis-strain-isolated-from-a-rat
#17
Nicolas Cabanel, Christiane Bouchier, Minoarisoa Rajerison, Elisabeth Carniel
Emergence of antibiotic-resistant Y. pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar were previously identified and characterized. Both strains carried conjugative plasmids that conferred resistance to streptomycin or to multiple antibacterial drugs. Here we characterized a novel Y. pestis strain (IP2180H) that exhibited resistance to doxycycline. This strain was isolated from a rat in Antananarivo (Madagascar) in 1998. Resistance was carried by a conjugative plasmid (pIP2180H) homologous to pB71 from Salmonella enterica...
October 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29021156/safety-and-accuracy-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-to-identify-highly-pathogenic-organisms
#18
James T Rudrik, Marty K Soehnlen, Michael J Perry, Maureen Sullivan, Wanda Reiter-Kintz, Philip A Lee, Denise Pettit, Anthony Tran, Erin Swaney
Matrix-assisted laser desorption ionization -- time of flight mass spectrometry (MALDI-TOF MS) sample preparation methods including the direct, on-plate formic acid, and ethanol/formic acid tube extraction were evaluated for their ability to render highly pathogenic organisms non-viable and safe for handling in a Biosafety Level-2 laboratory. Of these, the tube extraction procedure was the most successful, with none of the tested strains surviving this sample preparation method. Tube extracts from several agents of bioterrorism and their near neighbors were analyzed in an eight laboratory study to examine the utility of the Bruker Biotyper and Vitek MS MALDI-TOF MS systems and their IVD, research use only, and Security-Relevant databases, as applicable, to accurately identify these agents...
October 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28956397/-regulation-of-c-di-gmp-metabolism-and-biofilm-formation-in-yersinia-pestis
#19
Juping Zhao, Yicheng Sun
Yersinia pestis, the cause of plague, is transmitted by flea bite. Y. pestis forms a biofilm in the proventriculus of its flea vector to enhance transmission. Biofilm formation in Y. pestis is positively regulated by the intracellular levels of the second messenger cyclic diguanylate (c-di-GMP). The c-di-GMP in Y. pestis is synthesized by two diguanylate cyclases (DGC), HmsT and HmsD, and degraded by phosphodiesterase (PDE), HmsP. Here we summarized the regulators that modulate c-di-GMP metabolism and biofilm formation in Y...
September 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28934426/enhanced-macrophage-m1-polarization-and-resistance-to-apoptosis-enable-resistance-to-plague
#20
Emilia Pachulec, Rym Ben Abdelwahed Bagga, Lucie Chevallier, Hope O'Donnell, Chloé Guillas, Jean Jaubert, Xavier Montagutelli, Elisabeth Carniel, Christian E Demeure
Background: Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist various pathogens through the proinflammatory response of their M1 macrophages (MPs). However, they are susceptible to plague. It has been reported elsewhere that Mus spretus SEG mice resist plague and develop an immune response characterized by a strong recruitment of MPs. Methods: The responses of C57BL/6 and SEG MPs exposed to Yersinia pestis in vitro were examined...
September 15, 2017: Journal of Infectious Diseases
keyword
keyword
85966
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"