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https://www.readbyqxmd.com/read/28522707/draft-genome-sequence-of-the-luminescent-strain-vibrio-campbellii-lb102-isolated-from-a-black-tiger-shrimp-penaeus-monodon-broodstock-rearing-system
#1
Sujeet Kumar, Ashok Kumar Jangam, V Akhil, Vidya Rajendran, Vinaya Kumar Katneni, J Joseph Sahaya Rajan, Monendra Grover, Viswas Konasagara Nagaleekar, S V Alavandi, K K Vijayan
We report here the genome sequence of Vibrio campbellii LB102, isolated from the broodstock rearing system of a shrimp hatchery in India. Sequence analysis revealed the presence of effector toxins of the type III (YopT, sharing 39% identity with Yersinia pestis) and type VI (VgrG-3 and hemolysin coregulated protein of V. cholerae) secretion systems.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28520514/flea-and-small-mammal-species-composition-in-mixed-grass-prairies-implications-for-the-maintenance-of-yersinia-pestis
#2
Lauren P Maestas, Hugh B Britten
Maintenance of sylvatic plague in prairie dogs (Cynomis spp.) was once thought unlikely due to high mortality rates; yet more recent findings indicate that low-level enzootic plague may be maintained in susceptible prairie dog populations. Another hypothesis for the maintenance of sylvatic plague involves small mammals, other than prairie dogs, as an alternative reservoir in the sylvatic plague system. These hypotheses, however, are not mutually exclusive, as both prairie dogs and small mammals could together be driving sylvatic cycles of plague...
May 18, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28512097/glutathionylation-of-yersinia-pestis-lcrv-and-its-effects-on-plague-pathogenesis
#3
Anthony Mitchell, Christina Tam, Derek Elli, Thomas Charlton, Patrick Osei-Owusu, Farbod Fazlollahi, Kym F Faull, Olaf Schneewind
Glutathionylation, the formation of reversible mixed disulfides between glutathione and protein cysteine residues, is a posttranslational modification previously observed for intracellular proteins of bacteria. Here we show that Yersinia pestis LcrV, a secreted protein capping the type III secretion machine, is glutathionylated at Cys(273) and that this modification promotes association with host ribosomal protein S3 (RPS3), moderates Y. pestis type III effector transport and killing of macrophages, and enhances bubonic plague pathogenesis in mice and rats...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28504448/efficacy-of-a-fipronil-bait-in-reducing-the-number-of-fleas-oropsylla-spp-infesting-wild-black-tailed-prairie-dogs
#4
David M Poché, Daniel Hartman, Larisa Polyakova, Richard M Poché
Bubonic plague (Yersinia pestis) is a deadly zoonosis with black-tailed prairie dogs (Cynomys ludovicianus) as a reservoir host in the United States. Systemic insecticides are a promising means of controlling the vectors, Oropsylla spp. fleas, infesting these prairie dogs, subsequently disrupting the Y. pestis cycle. The objective of this study was to conduct a field trial evaluating the efficacy of a grain rodent bait containing fipronil (0.005%) against fleas infesting prairie dogs. The study was performed in Larimer County, CO, where bait was applied to a treatment area containing a dense prairie dog population, three times over a three-week period...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28487429/rationally-designed-tlr4-ligands-for-vaccine-adjuvant-discovery
#5
Kelsey A Gregg, Erin Harberts, Francesca M Gardner, Mark R Pelletier, Corinne Cayatte, Li Yu, Michael P McCarthy, Jason D Marshall, Robert K Ernst
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. MPLA is the product of chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while retaining adequate immunogenicity. Despite the virtually unlimited number of potential sources among bacterial strains, the number of useable compounds within this promising class of adjuvants are few. We have developed bacterial enzymatic combinatorial chemistry (BECC) as a method to generate rationally designed, functionally diverse lipid A...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28486652/swabbing-prairie-dog-burrows-for-fleas-that-transmit-yersinia-pestis-influences-on-efficiency
#6
David A Eads
Scientists and health-care professionals sometimes use a swabbing technique to collect fleas from rodent burrows, and later test the fleas for Yersinia pestis, the causative agent of plague. Detection of Y. pestis is enhanced when large pools of fleas are available. The following study investigated factors that might affect the rate at which fleas are collected from burrows in colonies of black-tailed prairie dogs (Cynomys ludovicianus). Data were collected from 13 colonies in New Mexico during 0600-1000 hours, June-August 2010-2011...
May 9, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28486528/identification-and-characterization-of-a-neutralizing-monoclonal-antibody-that-provides-complete-protection-against-yersinia-pestis
#7
Weicen Liu, Jun Ren, Jinlong Zhang, Xiaohong Song, Shuling Liu, Xiangyang Chi, Yi Chen, Zhonghua Wen, Jianmin Li, Wei Chen
Yersinia pestis (Y. pestis) has caused an alarming number of deaths throughout recorded human history, and novel prophylactics and therapeutics are necessary given its potential as a bioweapon. Only one monoclonal antibody has been identified to date that provides complete protection against Y. pestis. Here, we describe a second novel murine monoclonal antibody (F2H5) that provided complete protection against Y. pestis 141 infection when administered prophylactically to Balb/c mice (100 μg intravenously). We humanized F2H5, characterized its ability to bind to the Y...
2017: PloS One
https://www.readbyqxmd.com/read/28468083/-advance-on-genome-research-of-yersinia-pestis-bacteriophage
#8
H L Tan, P Wang, W Li
Completion of the genome sequences on Yersinia pestis bacteriophage offered unprecedented opportunity for researchers to carry out related genomic studies. This review was based on the genomic sequences and provided a genomic perspective in describing the essential features of genome on Yersinia pestis bacteriophage. Based on the comparative genomics, genetic evolutionary relationship was discussed. Description of functions from the gene prediction and protein annotation provided evidence for further related studies...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28463626/responses-of-juvenile-black-tailed-prairie-dogs-cynomys-ludovicianus-to-a-commercially-produced-oral-plague-vaccine-delivered-at-two-doses
#9
Elsa M Cárdenas-Canales, Lisa L Wolfe, Daniel W Tripp, Tonie E Rocke, Rachel C Abbott, Michael W Miller
We confirmed safety and immunogenicity of mass-produced vaccine baits carrying an experimental, commercial-source plague vaccine (RCN-F1/V307) expressing Yersinia pestis V and F1 antigens. Forty-five juvenile black-tailed prairie dogs ( Cynomys ludovicianus ) were randomly divided into three treatment groups (n=15 animals/group). Animals in the first group received one standard-dose vaccine bait (5×10(7) plaque-forming units [pfu]; STD). The second group received a lower-dose bait (1×10(7) pfu; LOW). In the third group, five animals received two standard-dose baits and 10 were left untreated but in contact...
May 2, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28455335/yersinia-pestis-resists-predation-by-acanthamoeba-castellanii-and-exhibits-prolonged-intracellular-survival
#10
Javier A Benavides-Montaño, Viveka Vadyvaloo
Plague is a flea-borne rodent-associated zoonotic disease caused by Yersinia pestis The disease is characterized by epizootics with high rodent mortalities, punctuated by inter-epizootic periods when the bacterium persists in an unknown reservoir. This study investigates the interaction between Y. pestis and the ubiquitous soil free-living amoeba (FLA), Acanthamoeba castellanii, to assess if the bacterium can survive within soil amoeba and whether intracellular mechanisms are conserved between infection of mammalian macrophages and soil amoeba...
April 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28418764/disease-surveillance-of-california-ground-squirrels-spermophilus-beecheyi-in-a-drive-through-zoo-in-oregon-usa
#11
Julia Ter Beest, Andrew Cushing, Modesto McClean, Wendy Hsu, Robert Bildfell
Rodents and other small wild mammals are often considered to be pests and vectors for disease in zoos that house small populations of valuable threatened and endangered animals. In 2005, three nonhuman primates at a drive-through zoo in Oregon, USA, acquired tularemia from an unknown source. Due to an abundance of California ground squirrels ( Spermophilus beecheyi ) on zoo grounds, we instituted serosurveillance of this species from July through September 2008 to determine the prevalence of antibodies against pathogens considered to be potentially transmissible to collection animals...
April 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28399281/potential-roles-of-pigs-small-ruminants-rodents-and-their-flea-vectors-in-plague-epidemiology-in-sinda-district-eastern-zambia
#12
Stanley S Nyirenda, Bernard M Hang'ombe, Bukheti S Kilonzo, Henry L Kangwa, Evans Mulenga, Ladslav Moonga
A cross-sectional study was conducted in the Eastern part of Zambia that previously reported a plague outbreak. The aim of the study was to evaluate the potential role of pigs, goats, and sheep as sero-surveillance hosts for monitoring plague, and to investigate the flea vectors and potential reservoir hosts to establish the current status of plague endemicity in the district. Serum samples were collected from 96 rodents, 10 shrews, 245 domestic pigs, 232 goats, and 31 sheep, whereas 106 organs were eviscerated from rodents and shrews...
May 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28398677/preparing-for-biological-threats-addressing-the-needs-of-pregnant-women
#13
REVIEW
Amelia K Watson, Sascha Ellington, Christina Nelson, Tracee Treadwell, Denise J Jamieson, Dana M Meaney-Delman
Intentional release of infectious agents and biological weapons to cause illness and death has the potential to greatly impact pregnant women and their fetuses. We review what is known about the maternal and fetal effects of seven biological threats: Bacillus anthracis (anthrax); variola virus (smallpox); Clostridium botulinum toxin (botulism); Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis); Yersinia pestis (plague); Francisella tularensis (tularemia); and Rickettsia prowazekii (typhus)...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28395471/-dynamics-of-f1-antibody-responses-to-yersinia-pestis-infection-in-rhombomys-opimus
#14
W W Meng, X H Wang, T Luo, B Li, Q G Wang, R Guo, X Dai, Y J Zhang
Objective: To observe the dynamics of antibody response in great gerbils infected with Yersinia pestis in experiment. Method: A total of 211 great gerbils were captured in the southern margin of plague natural focus of Junggar Basin of the Xinjiang Uygur Autonomous Region in 2011. Among them, there were 167 great gerbils without infection of Y. pestis and 44 great gerbils infected by Y.pestis. Y.pestis No. 2504 was employed for this experimental strain, which was strong toxic strain with negativity in the reduction experiment of nitrate...
April 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28393629/exploring-the-sequence-structure-function-relationship-for-the-intrinsically-disordered-%C3%AE-%C3%AE-crystallin-hahellin
#15
Meng Gao, Fei Yang, Lei Zhang, Zhengding Su, Yongqi Huang
βγ-Crystallins are a superfamily of proteins containing crystallin-type Greek key motifs. Some βγ-crystallin domains have been shown to bind Ca(2+). Hahellin is a newly identified intrinsically disordered βγ-crystallin domain from Hahella chejuensis. It folds into a typical βγ-crystallin structure upon Ca(2+) binding and acts as a Ca(2+)-regulated conformational switch. Besides Hahellin, another two putative βγ-crystallins from Caulobacter crescentus and Yersinia pestis are shown to be partially disordered in their apo-form and undergo large conformational changes upon Ca(2+) binding, although whether they acquire a βγ-crystallin fold is not known...
April 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28384062/fleas-of-black-footed-ferrets-and-their-potential-role-in-the-movement-of-plague
#16
Erica L Mize, Shaun M Grassel, Hugh B Britten
Sylvatic plague is one of the major impediments to the recovery of the black-footed ferret ( Mustela nigripes ) because it decimates their primary prey species, prairie dogs ( Cynomys spp.), and directly causes mortality in ferrets. Fleas are the primary vector of Yersinia pestis , the causative agent of sylvatic plague. The goal of this research was to better understand the flea fauna of ferrets and the factors that might influence flea abundance on ferrets. Fleas from ferrets were tested for Y. pestis in a post hoc assessment to investigate the plausibility that some ferrets could act as incidental transporter hosts of fleas infected with Y...
April 6, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28379405/unique-case-of-disseminated-plague-with-multifocal-osteomyelitis
#17
Leidy Tovar Padua, Amanda Kamali, Hannah Kim, Nicole M Green, Rachel Civen, Benjamin Schwartz, Paul Krogstad, Jaime Deville, Nava Yeganeh, Debra Lugo, Amira Baker, Priya Soni, Catherine Cho, Natalia Svircic, Sarah Dry, Leanne Seeger, Jessica Lloyd, Grace Deukmedjian, Richard Bowen, Gillian Hale, Sherif R Zaki, Paul Mead, Karin Nielsen-Saines
Plague is a disease caused by Yersinia pestis. Septicemic and pneumonic plague have a high mortality rate if untreated. Here we describe the challenges of accurately diagnosing a nonfatal pediatric case of septicemic plague with involvement of multiple organs; to our knowledge, the first documented case of multifocal plague osteomyelitis.
April 4, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28377623/a-starvation-induced-regulator-rovm-acts-as-a-switch-for-planktonic-biofilm-state-transition-in-yersinia-pseudotuberculosis
#18
Ruoxi Zhao, Yunhong Song, Qingyun Dai, Yiwen Kang, Junfeng Pan, Lingfang Zhu, Lei Zhang, Yao Wang, Xihui Shen
The transition between the planktonic state and the biofilm-associated state is a key developmental decision for pathogenic bacteria. Biofilm formation by Yersinia pestis is regulated by hmsHFRS genes (β-1, 6-N-acetyl-D-glucosamine synthesis operon) in its flea vector and in vitro. However, the mechanism of biofilm formation in Yersinia pseudotuberculosis remains elusive. In this study, we demonstrate that the LysR-type regulator RovM inversely regulates biofilm formation and motility in Y. pseudotuberculosis by acting as a transcriptional regulator of these two functions...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28339997/straight-run-vs-sex-separate-rearing-for-2-broiler-genetic-lines-part-1-live-production-parameters-carcass-yield-and-feeding-behavior
#19
M J Da Costa, S Zaragoza-Santacruz, T J Frost, J Halley, G M Pesti
The objective of this experiment was to evaluate the effects of raising broilers under sex separate and straight-run conditions for 2 broiler strains. Day-old Ross 308 and Ross 708 chicks (n = 1,344) were separated by sex and placed in 48 pens according to the rearing type: sex separate (28 males or 28 females) or straight-run (14 males + 14 females). There were 3 dietary phases: starter (zero to 17 d), grower (17 to 32 d), and finisher (32 to 48 d). Birds' individual BW and feed intakes were measured at 12, 17, 25, 32, 42, and 48 d to evaluate performance...
March 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339876/straight-run-vs-sex-separate-rearing-for-two-broiler-genetic-lines-part-2-economic-analysis-and-processing-advantages
#20
M J Da Costa, G Colson, T J Frost, J Halley, G M Pesti
The objective of this analysis was to evaluate the effects of raising broilers under sex separate and straight-run conditions for 2 broiler genetic lines. One-day-old Ross 308 and Ross 708 chicks (n = 1,344) were sex separated and placed in 48 pens according to rearing type: sex separate (28 males or 28 females) or straight-run (14 males + 14 females). There were 3 dietary phases: starter (zero to 17 d), grower (17 to 32 d), and finisher (32 to 48 d). Bird individual BW and group feed intakes were measured at 12, 17, 25, 32, 42, and 48 d to evaluate performance...
February 23, 2017: Poultry Science
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