William M de Souza, Marcilio J Fumagalli, Shirlene T S de Lima, Pierina L Parise, Deyse C M Carvalho, Cristian Hernandez, Ronaldo de Jesus, Jeany Delafiori, Darlan S Candido, Victor C Carregari, Stefanie P Muraro, Gabriela F Souza, Leda M Simões Mello, Ingra M Claro, Yamilka Díaz, Rodrigo B Kato, Lucas N Trentin, Clauber H S Costa, Ana Carolina B M Maximo, Karene F Cavalcante, Tayna S Fiuza, Vânia A F Viana, Maria Elisabeth L Melo, Clarissa P M Ferraz, Débora B Silva, Larissa M F Duarte, Priscilla P Barbosa, Mariene R Amorim, Carla C Judice, Daniel A Toledo-Teixeira, Mariana S Ramundo, Patricia V Aguilar, Emerson L L Araújo, Fabio T M Costa, Thiago Cerqueira-Silva, Ricardo Khouri, Viviane S Boaventura, Luiz Tadeu M Figueiredo, Rong Fang, Brechla Moreno, Sandra López-Vergès, Liana Perdigão Mello, Munir S Skaf, Rodrigo R Catharino, Fabiana Granja, Daniel Martins-de-Souza, Jessica A Plante, Kenneth S Plante, Ester C Sabino, Michael S Diamond, Eliseo Eugenin, José Luiz Proença-Módena, Nuno R Faria, Scott C Weaver
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infection, central nervous system damage, and elevated serum levels of pro-inflammatory cytokines and chemokines compared with survivors...
March 8, 2024: Cell Host & Microbe