Fernanda Mesa-Chavez, Yanin Chavarri-Guerra, Dione Aguilar-Y-Mendez, Andrea Becerril-Gaitan, Bryan F Vaca-Cartagena, Araceli Carrillo-Bedoya, Salvador Santiesteban-González, Alejandro Aranda-Gutierrez, Andrés Rodríguez-Faure, Daniela Obregon-Leal, Gregorio Quintero-Beuló, Jose L Rodriguez-Olivares, Melina Miaja, Jeffrey N Weitzel, Cynthia Villarreal-Garza
PURPOSE: Genetic cancer risk assessment (GCRA) provides pathogenic variant (PV) carriers with the invaluable opportunity to undertake timely cancer risk-reducing (RR) measures and initiate cascade testing (CT). This study describes the uptake of these strategies and the related barriers among breast cancer-associated germline PV carriers in Mexico. METHODS: Carriers who were at least 6 months after disclosure of genetic test results at two GCRA referral centers were invited to answer a survey assessing sociodemographic characteristics, awareness of their carrier status and its implications, uptake of RR measures according to international guidelines by PV, CT initiation, and associated challenges...
April 2024: JCO global oncology