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Allergic bronchopulmonary aspergillosis

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https://www.readbyqxmd.com/read/28914845/-allergic-bronchopulmonary-aspergillosis-in-patients-with-asthma-results-of-a-prospective-study
#1
Ya I Kozlova, E V Frolova, L V Filippova, A E Uchevatkina, O V Aak, N N Klimko
AIM: To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. SUBJECTS AND METHODS: A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28913161/a-young-immunocompetent-patient-with-spontaneous-aspergillus-empyema-who-developed-severe-eosinophilia
#2
Fumiaki Kudo, Hiromitsu Ohta, Yoshiaki Nagai, Kentaro Minegishi, Shinichiro Koyama
Aspergillus empyema is usually reported as a complication of surgical procedures, and spontaneous cases are quite rare. Here, we describe the case of a 16-year-old man who suddenly developed dyspnea despite previously being healthy. Chest computed tomography showed multiple mass-containing cavity lesions, pneumothorax, and pleural effusion in the left thorax. Within 2 weeks, Aspergillus fumigatus grew from his pleural effusion, thus he was diagnosed with Aspergillus empyema. He also developed severe eosinophilia after admission, and was treated with anti-fungal drugs...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28911045/azole-resistant-aspergillosis-epidemiology-molecular-mechanisms-and-treatment
#3
REVIEW
Anuradha Chowdhary, Cheshta Sharma, Jacques F Meis
Aspergillus fumigatus remains the most common species in all pulmonary syndromes, followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis, postoperative aspergillosis and fungal keratitis. The manifestations of Aspergillus infections include invasive aspergillosis, chronic pulmonary aspergillosis and bronchitis. Allergic manifestations of inhaled Aspergillus include allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Triazoles are the mainstay of therapy against Aspergillus infections for treatment and prophylaxis...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#4
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28864921/invasive-pulmonary-fungal-infections-in-cystic-fibrosis
#5
Carsten Schwarz, Claudia Brandt, Paul Whitaker, Sivagurunathan Sutharsan, Heino Skopnik, Silvia Gartner, Christina Smazny, Jobst F Röhmel
Invasive pulmonary mycosis is after allergic bronchopulmonary aspergillosis (ABPA) a frequent and severe complication of CF lung disease. Among CF caregivers, there is an insecurity when and how to treat infections of the lung parenchyma caused by different fungi in patients with CF. This case series provides a multicenter experience on diagnostic, manifestation, and treatment of non-ABPA cases of pulmonary. Non-ABPA cases of pulmonary mycoses in patients with CF have been collected from the CF Centers in Berlin, Essen, Worms, Frankfurt (Germany), Leeds (UK), and Barcelona (Spain)...
September 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28804700/abridged-version-of-the-awmf-guideline-for-the-medical-clinical-diagnostics-of-indoor-mould-exposure-s2k-guideline-of-the-german-society-of-hygiene-environmental-medicine-and-preventive-medicine-ghup-in-collaboration-with-the-german-association-of-allergists
#6
Gerhard A Wiesmüller, Birger Heinzow, Ute Aurbach, Karl-Christian Bergmann, Albrecht Bufe, Walter Buzina, Oliver A Cornely, Steffen Engelhart, Guido Fischer, Thomas Gabrio, Werner Heinz, Caroline E W Herr, Jörg Kleine-Tebbe, Ludger Klimek, Martin Köberle, Herbert Lichtnecker, Thomas Lob-Corzilius, Rolf Merget, Norbert Mülleneisen, Dennis Nowak, Uta Rabe, Monika Raulf, Hans Peter Seidl, Jens-Oliver Steiß, Regine Szewszyk, Peter Thomas, Kerttu Valtanen, Julia Hurraß
This article is an abridged version of the AWMF mould guideline "Medical clinical diagnostics of indoor mould exposure" presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28797493/allergic-and-noninvasive-infectious-pulmonary-aspergillosis-syndromes
#7
REVIEW
Eavan G Muldoon, Mary E Strek, Karen C Patterson
Aspergillus spp are ubiquitous in the environment, and inhalation of Aspergillus spores is unavoidable. An intact immune system, with normal airway function, protects most people from disease. Globally, however, the toll from aspergillosis is high. The literature has largely focused on invasive aspergillosis, yet the burden in terms of chronicity and prevalence is higher for noninvasive Aspergillus conditions. This article discusses allergic aspergilloses and provides an update on the diagnosis and management of allergic bronchopulmonary aspergillosis, including in patients with cystic fibrosis, and an update on severe asthma with fungal sensitization...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28768986/coexistence-of-pulmonary-aspergilloma-and-allergic-bronchopulmonary-aspergillosis
#8
Maiko Naito, Yu Kurahara
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28765819/a-review-of-42-asthmatic-children-with-allergic-bronchopulmonary-aspergillosis
#9
Ashok Shah, Shekhar Kunal
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) in children with asthma, not associated with cystic fibrosis, is yet to receive the recognition it deserves. OBJECTIVE: To highlight the presentation of ABPA in children with asthma. METHODS: This retrospective review documents the occurrence of pediatric ABPA over a period of 31 years in one unit. Children with asthma, eosinophilia and infiltrates on chest radiograph were screened for ABPA...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28702854/gastroesophageal-reflux-disease-and-pulmonary-diseases-associated-with-aspergillosis-is-there-a-connection
#10
Maria N Gamaletsou, David W Denning
INTRODUCTION: We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. BACKGROUND: Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. METHODS: We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD...
July 12, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28701850/invasive-mediastinal-aspergillosis-in-immunocompetent-male-with-invasion-of-left-atrium-and-hilar-structures
#11
Munta Kartik, Arun Kanala, Sunilnadikuda, S Manimala Rao, P Swathi Prakasham
Aspergillus is described as mould characterised by septate hyphae about 2-4μ in diameter, it is ubiquitous in nature and spreads by inhalation of spores. It causes opportunistic infections in almost six forms namely Allergic bronchopulmonary aspergillosis, Aspergillus sinusitis, Cutaneous aspergillosis, Aspergilloma, Chronic pulmonary aspergillosis, Invasive aspergillosis. Invasive aspergillosis of mediastinum in an immunocompetent patient has rarely been reported. We present a case of a young male who had presented with chest pain, cough and breathleness was later diagnosed as fulminant mediastinal aspergillosis...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28695805/clinical-analysis-of-77-patients-with-allergic-bronchopulmonary-aspergillosis-in-peking-union-medical-college-hospital
#12
Mingqiang Zhang, Jinming Gao
Objective To summarize the clinical features of allergic bronchopulmonary aspergillosis(ABPA)to facilitate its early diagnosis and treatment. Methods We retrospectively analyzed the clinical data of 77 patients who had been admitted to Peking Union Medical College Hospital from January 1996 to July 2015 with ABPA. Results The average age of these 77 patients(38 men and 39 women)was(41.8±18.3)years. The co-morbidities included bronchial asthma(n=74,96%)and pulmonary cystic fibrosis(n=3,4%). The main symptoms and signs of ABPA were chronic cough(100%),sputum production(97%),wheeze(86%),sputum plugs(25%),blood-stained sputum(18%),hemoptysis(9%),chest pain(9%),fever(47%),weight loss(30%),and night sweat(12%)...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28668248/modern-challenges-of-allergic-bronchopulmonary-aspergillosis-diagnosis-and-management-finding-from-a-case-study-with-a-history-of-rituximab-use
#13
Diego Blanco García-Granero, Daiana Guillén Vera, Carlos Grande, Ruth Barranco Jimenez, Consuelo Fernández Rodriguez, Irina Bobolea
No abstract text is available yet for this article.
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28653258/azole-resistance-in-aspergillus-fumigatus-in-patients-with-cystic-fibrosis-a-matter-of-concern
#14
A Hamprecht, F Morio, O Bader, P Le Pape, J Steinmann, E Dannaoui
Aspergillus fumigatus is the most frequent filamentous fungus isolated from respiratory specimens from patients with cystic fibrosis (CF). Triazoles are the most widely used antifungals in the treatment of allergic bronchopulmonary aspergillosis (ABPA) and invasive aspergillosis (IA) in CF patients. Treatment success could be severely compromised by the occurrence of azole-resistant A. fumigatus (ARAf), which is increasingly reported worldwide from both clinical samples and the environment. In previous studies, ARAf has been detected in up to 8% of CF patients...
June 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28649308/association-between-spirometry-controlled-chest-ct-scores-using-computer-animated-biofeedback-and-clinical-markers-of-lung-disease-in-children-with-cystic-fibrosis
#15
Thomas Kongstad, Kent Green, Frederik Buchvald, Marianne Skov, Tania Pressler, Kim Gjerum Nielsen
Background: Computed tomography (CT) of the lungs is the gold standard for assessing the extent of structural changes in the lungs. Spirometry-controlled chest CT (SCCCT) has improved the usefulness of CT by standardising inspiratory and expiratory lung volumes during imaging. This was a single-centre cross-sectional study in children with cystic fibrosis (CF). Using SCCCT we wished to investigate the association between the quantity and extent of structural lung changes and pulmonary function outcomes, and prevalence of known CF lung pathogens...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28645480/comparative-performance-of-aspergillus-galactomannan-elisa-and-pcr-in-sputum-from-patients-with-abpa-and-cpa
#16
Samuel Fayemiwo, Caroline B Moore, Philip Foden, David W Denning, Malcolm D Richardson
OBJECTIVES: Galactomannan (GM) and Aspergillus DNA detection are useful tools for the diagnosis of invasive pulmonary aspergillosis (IPA), primarily in blood and bronchoscopy samples. This study aimed to evaluate the utility of both markers for detection of Aspergillus in sputum from patients with allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA). METHODS: ABPA or CPA demographic patient data were retrieved. This retrospective observational audit included 159 patients with at least one sputum pair...
June 21, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28552257/-allergic-bronchopulmonary-aspergillosis-evaluation-of-a-maintenance-therapy-with-nebulized-ambisome-%C3%A2
#17
C Godet, F Couturaud, S Ragot, F Laurent, A L Brun, A Bergeron, J Cadranel
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) affects 3-13% of patients with asthma. Its natural history includes possibly life-threatening exacerbations and evolution towards fixed obstructive ventilatory disorders or even irreversible lung fibrosis lesions. ABPA prognosis is directly associated with exacerbation control and the main objective of the treatment is to decrease their frequency and duration. Recommendations regarding dosage and duration of treatment are not very precise...
May 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28546015/allergic-bronchopulmonary-aspergillosis-in-japan-a-nationwide-survey
#18
Tsuyoshi Oguma, Masami Taniguchi, Terufumi Shimoda, Katsuhiko Kamei, Hiroto Matsuse, Akira Hebisawa, Noboru Takayanagi, Satoshi Konno, Koichi Fukunaga, Kazuki Harada, Jun Tanaka, Katsuyoshi Tomomatsu, Koichiro Asano
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. METHODS: In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases...
May 23, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28530849/allergic-bronchopulmonary-aspergillosis-in-cystic-fibrosis-mr-imaging-of-airway-mucus-contrasts-as-a-tool-for-diagnosis
#19
Gaël Dournes, Patrick Berger, John Refait, Julie Macey, Stephanie Bui, Laurence Delhaes, Michel Montaudon, Olivier Corneloup, Jean-François Chateil, Roger Marthan, Michaël Fayon, François Laurent
Purpose To assess the diagnostic accuracy of mucus contrast characterization by using magnetic resonance (MR) imaging to discriminate allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Materials and Methods The study was approved by the local Ethics Committee, and all patients or their parents gave written informed consent. One hundred ten consecutive patients with CF were screened between January 2014 and July 2015. All patients underwent a non-contrast material-enhanced MR protocol that included routine T1-weighted and T2-weighted sequences...
October 2017: Radiology
https://www.readbyqxmd.com/read/28526275/increasing-total-serum-ige-allergic-bronchopulmonary-aspergillosis-and-lung-function-in-cystic-fibrosis
#20
Florian Gothe, Matthias Kappler, Matthias Griese
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder contributing to lung disease in cystic fibrosis (CF) and challenging to diagnose. OBJECTIVE: This study analyzed the predictive value of increasing total IgE (t-IgE) levels in a CF cohort alongside with clinical and serologic data. METHODS: A total of 387 children and young adults were followed from 2000 to 2006 and retrospectively classified into 6 groups...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
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