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Biological treatment

Polina Zjablovskaja, Petr Danek, Miroslava Kardosova, Meritxell Alberich-Jorda
Understanding of the hematopoietic stem and progenitor cell biology has important implications for regenerative medicine and the treatment of hematological pathologies. Despite the most relevant data that can be acquired using in vivo models or primary cultures, the low abundance of hematopoietic stem and progenitor cells considerably restricts the pool of suitable techniques for their investigation. Therefore, the use of cell lines allows sufficient production of biological material for the performance of screenings or assays that require large cell numbers...
February 21, 2018: Journal of Visualized Experiments: JoVE
Yi-Feng Carol Lan, Diane C Zelman, Wen-Tao Chao
Bipolar disorder (BD) affects a significant proportion of Taiwanese individuals (Weissman et al., 1996; Yang, Yeh, & Hwu, 2012). Psychotropic medications are typically the mainstay of treatment for BD, and there is an abundance of international research on biological etiology and medication options. However, there is comparatively little research on psychosocial aspects of BD, including how it is understood and managed within families. As culture provides the context in which psychiatric disease is managed, there is a need to identify distinct Chinese psychosocial perspectives that might shed light on intervention options...
January 1, 2018: Transcultural Psychiatry
Sai-Sai Tian, Jian Yang, Jing Zhao, Wei-Dong Zhang
With the completion of the human genome project, people have gradually recognized that the functions of the biological system are fulfilled through network-type interaction between genes, proteins and small molecules, while complex diseases are caused by the imbalance of biological processes due to a number of gene expression disorders. These have contributed to the rise of the concept of the "multi-target" drug discovery. Treatment and diagnosis of traditional Chinese medicine are based on holism and syndrome differentiation...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Zhihong Liu, Youfu Zhang, Zhidan Xu
PURPOSE: It has been reported that UNC119 is significantly up-regulated in liver cancer cells. However, the role of UNC119 in liver cancer and the clinical significance of reducing its expression in hepatocellular carcinoma (HCC) are not well understood. The aim of this study was to investigate the expression profile of UNC119 in HCC and its connection with the progression of HCC. METHODS: UNC119 expression in HCC cell lines and tissues was assessed using quantitative real-time PCR, western blot and immunohistochemical analyses...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Zhihong Liu, Youfu Zhang, Zhidan Xu
PURPOSE: It has been reported that UNC119 is significantly up-regulated in liver cancer cells. However, the role of UNC119 in liver cancer and the clinical significance of reducing its expression in hepatocellular carcinoma (HCC) are not well understood. The aim of this study was to investigate the expression profile of UNC119 in HCC and its connection with the progression of HCC. METHODS: UNC119 expression in HCC cell lines and tissues was assessed using quantitative real-time PCR, western blot and immunohistochemical analyses...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jianying Shen, Jian Zhou, Yong Lin, Zhen Liu, Ping Chen, Xianchun Wang
Plasma membrane (PM) and mitochondrial membrane (MM) proteins of rat hippocampal neurons were identified and comparatively characterized on the basis of a sequential digestion-centered combinative strategy for sample treatment. A total of 478 membrane proteins were identified, of which 240 had PM localization, 170 had MM localization, and 33 had both of the two subcellular localizations. Compared with the PM proteome, the MM proteome not only was smaller, more basic, and more hydrophobic, but also had a narrower protein molecular mass distribution range and a higher proportion of transmembrane proteins...
March 19, 2018: Analytical and Bioanalytical Chemistry
Mamatha Siricilla, Lydia Irwin, Andres Ferber
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of nonclassical Hodgkin lymphoma (HL). It resembles non-Hodgkin lymphoma (NHL), by expressing classic B cell markers such as CD20 and CD79a however lacks definitive HL markers (such as CD15 and CD30). T cell histiocyte-rich large B cell lymphoma (THRLBCL), on the other hand, is a distinct entity classified under NHL and considered a variant of diffuse large B cell lymphoma (DLBCL). NLPHL can look morphologically and immunologically similar to THRLBCL and often poses a diagnostic challenge...
2018: Case Reports in Oncological Medicine
Chunmei Xu, Junyu Zhao, Xiaojun Zhou, Rui Zhang, Tianyue Xie, Zhiwei Zou, Lin Liao, Jianjun Dong
Background: Liver enzyme abnormalities are common in patients with type 2 diabetes. Currently, the inverse relationship between elevated liver enzymes and antidiabetics intake may be explained by rigorous treatment and good control. However, few studies have directly explored the influence of antidiabetics on abnormal liver function, especially the comparison between two insulin sensitizers-thiazolidinediones and metformin. Materials And Methods: Databases, including PubMed, Cochrane, CNKI, Wanfang and VIP were searched...
February 23, 2018: Oncotarget
Ke-Wang Luo, Wing-Yin Lung, Chun-Xie, Xin-Le Luo, Wei-Ren Huang
Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. We previously found that EGCG inhibited SW780 tumor growth by down-regulation of NF-κB and MMP-9. This study demonstrated that EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K/AKT pathway, without modulation of NF-κB. Our results showed that treatment of EGCG resulted in significant inhibition of cell proliferation by induction of apoptosis, without obvious toxicity to normal bladder SV-HUC-1 cells...
February 23, 2018: Oncotarget
Rong Liang, Yan Lin, Chun-Ling Yuan, Zhi-Hui Liu, Yong-Qiang Li, Xiao-Ling Luo, Jia-Zhou Ye, Hai-Hong Ye
Colorectal cancer (CRC) is one of the most common types of malignancy with high morbidity and mortality rates worldwide. This biologically heterogeneous disease results in diverse therapeutic responses, thus, novel prognostic biomarkers are required to improve CRC treatment. Estrogen-related receptor α (ERRα) is a nuclear orphan receptor, which is associated with estrogen receptor α. The present study aimed to investigate the expression of ERRα in patients with CRC, and explore the association between ERRα expression and clinicopathological factors, local recurrence and prognosis...
April 2018: Oncology Letters
Suolin Zhang, Yayan Wang
Expression of angiotensin II (Ang II), a key biological peptide in the renin-angiotensin system, is closely associated with the occurrence and development of cancer. Ang II binds two receptor subtypes, the Ang II type 1 receptor (AT1R) and the AT2R, to mediate a series of biological effects. Telmisartan, a specific AT1R blocker, has been reported to have potential as an anticancer drug for treating renal cancer. In the present study, whether telmisartan had an effect on non-small cell lung cancer (NSCLC) cell proliferation and migration was investigated...
April 2018: Oncology Letters
Zhanpeng Luo, Dawei Li, Xiaobo Luo, Litao Li, Suxi Gu, Long Yu, Yuanzheng Ma
The present study aimed to determine the mechanisms of action of curcumin in osteosarcoma. Human osteosarcoma U-2 OS cells was purchased from the Cell Bank of the Chinese Academy of Sciences. RNA sequencing analysis was performed for 2 curcumin-treated samples and 2 control samples using Illumina deep sequencing technology. The differentially expressed genes were identified using Cufflink software. Enrichment and protein-protein interaction network analyses were performed separately using cluster Profiler package and Cytoscape software to identify key genes...
April 2018: Oncology Letters
Jinxia Wu, Wenqi Du, Xiucun Wang, Lulu Wei, Yaojie Pan, Xiaojin Wu, Jinling Zhang, Dongsheng Pei
Ras-related protein (Rap)2a and Rap2b are members of the GTP-binding protein family, and serve an important function in tumor progression. However, the associations between Rap2c and cancer cell functions have not yet been reported. Osteosarcoma is a type of bone cancer; its high degree of invasion is considered to be a major treatment challenge. The present study first investigated the biological role of Rap2c in human osteosarcoma cells and investigated the underlying mechanism of Rap2c on osteosarcoma cell migration and invasion...
April 2018: Oncology Letters
Molly J Dingel, Jenny Ostergren, Kathleen Heaney, Barbara A Koenig, Jennifer McCormick
The gene has infiltrated the way citizens perceive themselves and their health. However, there is scant research that explores the ways genetic conceptions infiltrate individuals' understanding of their own health as it relates to a behavioral trait, like addiction. Do people seeking treatment for addiction ground their self-perception in biology in a way that shapes their experiences? We interviewed 63 participants in addiction treatment programs, asking how they make meaning of a genetic understanding of addiction in the context of their recovery, and in dealing with the stigma of addiction...
December 2017: BioSocieties
Raffaele Nuzzi, Simona Scalabrin, Alice Becco, Giancarlo Panzica
Aim: Gonadal hormones are essential for reproductive function, but can act on neural and other organ systems, and are probably the cause of the large majority of known sex differences in function and disease. The aim of this review is to provide evidence for this hypothesis in relation to eye disorders and to retinopathies in particular. Methods: Epidemiological studies and research articles were reviewed. Results: Analysis of the biological basis for a relationship between eye diseases and hormones showed that estrogen, androgen, and progesterone receptors are present throughout the eye and that these steroids are locally produced in ocular tissues...
2018: Frontiers in Endocrinology
Lisa Wagels, Mikhail Votinov, Thilo Kellermann, Albrecht Eisert, Cordian Beyer, Ute Habel
Testosterone affects human social behavior in various ways. While testosterone effects are generally associated with muscular strength and aggressiveness, human studies also point towards enhanced status-seeking motives after testosterone administration. The current study tested the causal influence of exogenous testosterone on male behavior during a competitive provocation paradigm. In this double blind, randomized, placebo (PL)-controlled study, 103 males were assigned to a PL or testosterone group receiving a colorless PL or testosterone gel...
2018: Frontiers in Behavioral Neuroscience
Hak-Jae Kim, Chun-Geon Park, Rakesh Varghese, Ji Yeon Lee, YoungOck Kim, Gi-Ho Sung
The leaf of Aurea helianthus ( A. helianthus Jinhuakui) is popularly used in China traditional medicine, however, scientific evidence on its antioxidant properties rarely studied. In this study, biological activities of A. helianthus leave's 80% ethanol extract (AHL) were investigated. The measured total polyphenol and flavonoid content of AHL was 184.24 ± 5.01 mg GAE/g and 102.53 ± 0.98 mg NAR/g. AHL showed the highest α, α -diphenyl- β -picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS) radical scavenging activities of 98...
December 2017: Saudi Journal of Biological Sciences
Shu Yang, Zhihua Xing, Tao Liu, Jing Zhou, Qinghua Liang, Tao Tang, Hanjin Cui, Weijun Peng, Xingui Xiong, Yang Wang
Background: Rheumatoid arthritis (RA) is a common worldwide public health problem, which causes a chronic, systemic inflammatory disorder of synovial joints. Paeoniflorin (PA) has achieved positive results to some extent for the treatment of RA. Purpose: This study aimed to reveal the potential druggable targets of PA in an experimental RA model using quantitative proteomics analysis. Study design and methods: Thirty Sprague-Dawley rats were randomly divided into a normal group, model group and PA group...
2018: Drug Design, Development and Therapy
Michela Lupia, Francesca Angiolini, Giovanni Bertalot, Stefano Freddi, Kris F Sachsenmeier, Elisa Chisci, Barbara Kutryb-Zajac, Stefano Confalonieri, Ryszard T Smolenski, Roberto Giovannoni, Nicoletta Colombo, Fabrizio Bianchi, Ugo Cavallaro
Cancer-initiating cells (CICs) have been implicated in tumor development and aggressiveness. In ovarian carcinoma (OC), CICs drive tumor formation, dissemination, and recurrence, as well as drug resistance, thus accounting for the high death-to-incidence ratio of this neoplasm. However, the molecular mechanisms that underlie such a pathogenic role of ovarian CICs (OCICs) remain elusive. Here, we have capitalized on primary cells either from OC or from its tissues of origin to obtain the transcriptomic profile associated with OCICs...
March 10, 2018: Stem Cell Reports
Loveth O Linus, Shi-Lei Wang, Ning Shi, Christian Hanson, Yi-Tong Lu, Raphael N Alolga, Qun Liu, Reginald C Njokuocha, Lian-Wen Qi
ETHNOPHARMACOLOGICAL RELEVANCE: Parinari kerstingii Engl. extract is traditionally used for the treatment of inflammation, bronchopneumonia, feverish pains, and breast cancer. However, there have not been any scientific reports regarding the medicinal properties of this plant, and no experiments have been done to ascertain the safety of the extract. AIM OF THE STUDY: The objective of this work was to evaluate the toxicity of Parinari kerstingii Engl. extracts as an herbal remedy and to investigate its anti-inflammatory potential in vivo...
March 15, 2018: Journal of Ethnopharmacology
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