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https://www.readbyqxmd.com/read/29033678/quantitative-metabolic-volumetric-product-on-18-fluorine-2fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-in-assessing-treatment-response-to-disease-modifying-antirheumatic-drugs-in-rheumatoid-arthritis-multiparametric-analysis-integrating
#1
Nandigam Santosh Kumar, Yogesh Shejul, Ramesh Asopa, Sandip Basu
The purpose of this study was to assess the role of fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in the evaluation of treatment response evaluation to disease-modifying antirheumatic drug (DMARD) therapy in patients of rheumatoid arthritis (RA). A total of ten patients with proven diagnosis of RA as per the 2010 American College of Rheumatology/European League against Rheumatism (EULAR) criteria were prospectively evaluated. All patients underwent clinical and biochemical evaluation and a baseline FDG-PET/CT with assessment of maximum standardized uptake value and metabolic volumetric product (MVP) values...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29023282/abatacept-monotherapy-versus-abatacept-plus-methotrexate-for-treatment-refractory-rheumatoid-arthritis
#2
Tristan Pascart, Peggy Philippe, Elodie Drumez, Xavier Deprez, Bernard Cortet, Alain Duhamel, Eric Houvenagel, René-Marc Flipo
BACKGROUND: Methotrexate combination therapy improves abatacept efficacy as a first-line biologic agent for the treatment of rheumatoid arthritis, but it is unclear when abatacept is used later on, particularly after non-TNF inhibitor (TNFi) failure. STUDY QUESTION: The objective of this study was to determine whether treatment response after non-TNFi inadequate response is different in patients with rheumatoid arthritis (RA) treated with abatacept in combination with or not with methotrexate...
September 12, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29018568/person-focused-care-for-young-people-with-rheumatic-and-musculoskeletal-diseases-young-rheumatologists-and-eular-young-pare-perspectives
#3
Alessia Alunno, Paul Studenic, Elena Nikiphorou, Petra Balážová, Linda van Nieuwkoop, Sofia Ramiro, Francesco Carubbi, Christophe Richez, Nele Caeyers, Laure Gossec, Marios Kouloumas
In recent years, the evolution of healthcare challenged the management of people with rheumatic and musculoskeletal diseases (RMDs). From disease-centred care to person-focused care, a holistic approach along with patient empowerment about their disease, improved the physician-patient relationship and allowed to achieve better outcomes with lower healthcare costs. Nevertheless, RMDs may occur from childhood to the old age and to date very few studies have addressed the needs and priorities of young people with RMDs...
2017: RMD Open
https://www.readbyqxmd.com/read/29017177/patients-with-newly-diagnosed-rheumatoid-arthritis-are-at-increased-risk-of-diabetes-mellitus-an-observational-cohort-study
#4
Amir Emamifar, Klaus Levin, Inger Marie Jensen Hansen
AIMS: To reveal the prevalence of Diabetes Mellitus (DM) in patients with newly diagnosed Rheumatoid Arthritis (RA) and evaluate the association between clinical characteristics of RA and DM as well as treatment response in newly diagnosed RA patients with DM. METHODS: Newly diagnosed, adult, RA patients, who were registered in Danish Danbio since 1st January 2010, were included. Patients' demographics, serology results including rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP) and antinuclear antibody (ANA) as well as disease activity score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danbio Registry...
September 28, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28980908/serum-il-7-as-diagnostic-biomarker-for-rheumatoid-arthritis-validation-with-eular-2010-classification-criteria
#5
Agata N Burska, Jessica Neilan, Ruth E Chisman, Rujiraporn Pitaksalee, Richard Hodgett, Helena Marzo-Ortega, Philip G Conaghan, Robert West, Paul Emery, Frederique Ponchel
OBJECTIVES: Despite the well-established value of currently used classification criteria for the early diagnosis of rheumatoid arthritis (RA) there is a constant demand for novel biomarkers notably in autoantibody-negative patients. Interleukin 7 (IL-7) has been reported as a candidate diagnostic biomarker based on ACR-1987 criteria. However, clinical practice has moved to using the EULAR 2010 classification criteria. Therefore, to advance the use of IL-7 alongside the RA biomarker pipeline, we repeated the original study in a new cohort...
September 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28977549/2016-acr-eular-adult-dermatomyositis-and-polymyositis-and-juvenile-dermatomyositis-response-criteria-methodological-aspects
#6
Lisa G Rider, Nicolino Ruperto, Angela Pistorio, Brian Erman, Nastaran Bayat, Peter A Lachenbruch, Howard Rockette, Brian M Feldman, Adam M Huber, Paul Hansen, Chester V Oddis, Ingrid E Lundberg, Anthony A Amato, Hector Chinoy, Robert G Cooper, Lorinda Chung, Katalin Danko, David Fiorentino, Ignacio García-De la Torre, Ann M Reed, Yeong Wook Song, Rolando Cimaz, Rubén J Cuttica, Clarissa A Pilkington, Alberto Martini, Janjaap van der Net, Susan Maillard, Frederick W Miller, Jiri Vencovsky, Rohit Aggarwal
Objective: The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM. Methods: Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consensus gold-standard ratings of minimal, moderate and major improvement. Experts completed a survey regarding clinically meaningful improvement in the core set measures (CSM) and a conjoint-analysis survey (using 1000Minds software) to derive relative weights of CSM and candidate definitions...
August 2, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968896/recent-pharmacological-advances-in-the-management-of-gout
#7
Kristen Davies, Marwan A S Bukhari
Gout is the most common cause of inflammatory arthritis worldwide, and reports show that despite availability of therapies, management is still suboptimal. The new EULAR 2016 recommendations for the treatment of gout highlight the huge development in gout therapies, and the number of drugs being trialled only continues to increase. A clinical review of the evidence that underlies the recommendations from EULAR can reveal possible gaps in the literature and avenues for future research into gout therapies.
September 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968699/validation-of-the-eular-definition-of-arthralgia-suspicious-for-progression-to-rheumatoid-arthritis
#8
Leonie E Burgers, Filip Siljehult, Robin M Ten Brinck, Hanna W van Steenbergen, Robert B M Landewé, Solbritt Rantapää-Dahlqvist, Annette H M van der Helm-van Mil
Objectives: Recently a EULAR-taskforce defined arthralgia suspicious for progression to RA, in order to allow inclusion of homogeneous sets of arthralgia patients in clinical studies. This longitudinal study aimed (i) to validate this definition in arthralgia patients in whom rheumatologists felt that imminent RA was more likely than other arthralgias [clinically suspect arthralgia (CSA)], that is, the target population fulfilling the entry criterion, and (ii) to explore the performance in arthralgia patients who were referred to secondary care prior to rheumatological evaluation, hence ignoring the entry criterion...
August 31, 2017: Rheumatology
https://www.readbyqxmd.com/read/28967358/causes-of-pain-in-patients-with-axial-spondyloarthritis
#9
REVIEW
Uta Kiltz, Xenofon Baraliakos, Andrea Regel, Bjoern Bühring, Juergen Braun
Back pain, most frequently of the inflammatory type, is the leading symptom in patients with axial spondyloarthritis (axSpA). Back pain in these patients is usually either due to axial inflammation or structural changes based on new bone formation. However, there are other possible causes of pain in these patients. There is, for example, a strongly increased risk of vertebral fractures, and, especially in patients with longstanding disease, degenerative spinal changes may play an additional role as a cause of pain...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28965771/enhanced-expression-of-nlrp3-inflammasome-related-inflammation-in-peripheral-blood-mononuclear-cells-in-sj%C3%A3-gren-s-syndrome
#10
Seong-Kyu Kim, Jung-Yoon Choe, Geon Ho Lee
OBJECTIVE: The aim of this study was to identify the association of NLRP3 inflammasome-induced inflammation with disease activity and damage in Sjögren's syndrome. METHODS: A total of 33 female patients with Sjögren's syndrome and 34 sex- and age-matched, healthy controls were consecutively enrolled. The mRNA expression levels of NLRP3, ASC, caspase-1, interleukin-1β (IL-1β), and IL-18 in peripheral blood mononuclear cells (PBMCs) were measured, as well as serum IL-1β and IL-18 protein expression levels...
September 29, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28955487/validation-of-the-eular-era-edta-recommendations-for-the-management-of-anca-associated-vasculitis-by-disease-content-experts
#11
Max Yates, Richard Watts, Ingeborg Bajema, Maria Cid, Bruno Crestani, Thomas Hauser, Bernhard Hellmich, Julia Holle, Martin Laudien, Mark A Little, Raashid Ahmed Luqmani, Alfred Mahr, Peter Merkel, John Mills, Janice Mooney, Mårten Segelmark, Vladimir Tesar, Kerstin W A Westman, Augusto Vaglio, Nilüfer Yalçındağ, David R Jayne, Chetan Mukhtyar
The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted on by members of a learned society. This paper explores the wider validity of the recommendations among people who self-identify as clinicians caring for patients with vasculitis. In addition to the task force, a learned society (European Vasculitis Society-EUVAS) was invited, through online survey, to rate independently the strength of evidence of each recommendation to obtain an indication of the agreement among the final target audience and ultimate end-users of the recommendations...
2017: RMD Open
https://www.readbyqxmd.com/read/28948984/scoring-ultrasound-synovitis-in-rheumatoid-arthritis-a-eular-omeract-ultrasound-taskforce-part-2-reliability-and-application-to-multiple-joints-of-a-standardised-consensus-based-scoring-system
#12
Lene Terslev, Esperanza Naredo, Philippe Aegerter, Richard J Wakefield, Marina Backhaus, Peter Balint, George A W Bruyn, Annamaria Iagnocco, Sandrine Jousse-Joulin, Wolfgang A Schmidt, Marcin Szkudlarek, Philip G Conaghan, Emilio Filippucci, Maria Antonietta D'Agostino
OBJECTIVES: To test the reliability of new ultrasound (US) definitions and quantification of synovial hypertrophy (SH) and power Doppler (PD) signal, separately and in combination, in a range of joints in patients with rheumatoid arthritis (RA) using the European League Against Rheumatisms-Outcomes Measures in Rheumatology (EULAR-OMERACT) combined score for PD and SH. METHODS: A stepwise approach was used: (1) scoring static images of metacarpophalangeal (MCP) joints in a web-based exercise and subsequently when scanning patients; (2) scoring static images of wrist, proximal interphalangeal joints, knee and metatarsophalangeal joints in a web-based exercise and subsequently when scanning patients using different acquisitions (standardised vs usual practice)...
2017: RMD Open
https://www.readbyqxmd.com/read/28948983/scoring-ultrasound-synovitis-in-rheumatoid-arthritis-a-eular-omeract-ultrasound-taskforce-part-1-definition-and-development-of-a-standardised-consensus-based-scoring-system
#13
Maria-Antonietta D'Agostino, Lene Terslev, Philippe Aegerter, Marina Backhaus, Peter Balint, George A Bruyn, Emilio Filippucci, Walter Grassi, Annamaria Iagnocco, Sandrine Jousse-Joulin, David Kane, Esperanza Naredo, Wolfgang Schmidt, Marcin Szkudlarek, Philip G Conaghan, Richard J Wakefield
OBJECTIVES: To develop a consensus-based ultrasound (US) definition and quantification system for synovitis in rheumatoid arthritis (RA). METHODS: A multistep, iterative approach was used to: (1) evaluate the baseline agreement on defining and scoring synovitis according to the usual practice of different sonographers, using both grey-scale (GS) (synovial hypertrophy (SH) and effusion) and power Doppler (PD), by reading static images and scanning patients with RA and (2) evaluate the influence of both the definition and acquisition technique on reliability followed by a Delphi exercise to obtain consensus definitions for synovitis, elementary components and scoring system...
2017: RMD Open
https://www.readbyqxmd.com/read/28943233/unravelling-fibromyalgia-steps-towards-individualized-management
#14
Winfried Häuser, Serge Perrot, Daniel J Clauw, Mary-Ann Fitzcharles
The heterogeneity of the clinical presentation and the pathophysiologic mechanisms associated with fibromyalgia (FM), and the modest results on average for any therapy, call for a more individualized management strategy. Individualized treatment can be based on subgrouping of patients according to associated conditions (mental health problems; chronic overlapping pain conditions; other somatic diseases) or on the disease severity. Categorizing FM as mild, moderate or severe can be based on clinical assessment (e...
September 21, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28941024/serum-levels-of-hmgb1-and-srage-are-associated-to-extraglandular-involvement-and-disease-activity-as-defined-by-essdai-in-sj%C3%A3-gren-s-syndrome
#15
Anna-Maria Kanne, Maike Jülich, Amira Mahmutovic, Isabella Tröster, Bettina Sehnert, Vilma Urbonaviciute, Reinhard E Voll, Florian Kollert
OBJECTIVE: To assess serum levels of high mobility group box 1 (HMGB1) and the soluble receptor for advanced glycation endproducts (sRAGE) in patients with Sjögren's Syndrome (SS) and explore correlations with disease activity. METHODS: Thirty-nine patients with SS and 21 healthy controls (HC) were included in this cross-sectional study. Clinical and laboratory values were obtained from all patients. Disease activity was assessed by European League against Rheumatism (EULAR) SS disease activity index (ESSDAI)...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28932306/prevalence-of-asymptomatic-arterial-hypertension-and-its-correlation-with-inflammatory-activity-in-early-rheumatoid-arthritis
#16
Ismet H Bajraktari, Sylejman Rexhepi, Idriz Berisha, Ali Lahu, Avni Kryeziu, Bastri Durmishi, Halit Bajraktari, Elton Bahtiri
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that worsens during the course of the disease and can cause disability. Early RA refers to the onset of symptoms within the past 3 months. In RA, increased levels of mediators of inflammation may cause arterial stiffness consequently leading to arterial hypertension. AIM: The aim of this cross-sectional study was to assess the prevalence of asymptomatic arterial hypertension in early RA patients as well as the correlation with parameters of inflammation...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28921059/very-early-systemic-sclerosis-and-pre-systemic-sclerosis-definition-recognition-clinical-relevance-and-future-directions
#17
REVIEW
Silvia Bellando-Randone, Marco Matucci-Cerinic
PURPOSE OF REVIEW: The approach to systemic sclerosis (SSc) has changed over the years with an increasing focus on the very early diagnosis of the disease. The terminology identifying patients in the early phase of SSc has been significantly confusing in the last three decades. The purpose of this article is to analyze how the concept of "very early SSc" has evolved over the years, which is the role of an early diagnosis and how early treat patients. RECENT FINDINGS: Several attempts have been made over time, to create more sensitive and specific classification criteria to include the largest number of SSc patients, also in the earliest phase...
September 18, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28913747/primary-sj%C3%A3-gren-s-syndrome-extraglandular-manifestations-and-hydroxychloroquine-therapy
#18
J Demarchi, S Papasidero, M A Medina, D Klajn, R Chaparro Del Moral, O Rillo, V Martiré, G Crespo, A Secco, A Catalan Pellet, C Amitrano, C Crow, C Asnal, P Pucci, F Caeiro, N Benzanquen, J P Pirola, M Mayer, F Zazzetti, S Velez, J Barreira, N Tamborenea, L Santiago, L Raiti
The use of hydroxychloroquine (HCQ) in Primary Sjögren's Syndrome (pSS) has been assessed in different studies over the last years, with conflicting results regarding its efficacy in sicca syndrome and extraglandular manifestations (EGM). The goal of this study was to compare the incidence rate of EGM in pSS patients with and without HCQ therapy.We performed a multicenter retrospective study, including patients with pSS (European classification criteria) with at least 1 year of follow-up. Subjects with concomitant fibromyalgia, autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis were excluded...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28895041/unmet-needs-in-the-pathogenesis-and-treatment-of-vasculitides
#19
REVIEW
Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani
Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria...
September 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28894946/an-international-survey-on-non-invasive-techniques-to-assess-the-microcirculation-in-patients-with-raynaud-s-phenomenon-sunshine-survey
#20
Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and upper limb arterial Doppler ultrasound. Emails with a link to the survey were sent to physicians from the European Scleroderma Trials and Research group (EUSTAR), the EULAR Study Group on Microcirculation in Rheumatic Diseases (SG_MC/RD) and members of the pediatric rheumatology Email board...
September 11, 2017: Rheumatology International
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