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https://www.readbyqxmd.com/read/28107378/polymorphisms-in-stat4-ptpn2-psors1c1-and-traf3ip2-genes-are-associated-with-the-response-to-tnf-inhibitors-in-patients-with-rheumatoid-arthritis
#1
Paola Conigliaro, Cinzia Ciccacci, Cristina Politi, Paola Triggianese, Sara Rufini, Barbara Kroegler, Carlo Perricone, Andrea Latini, Giuseppe Novelli, Paola Borgiani, Roberto Perricone
OBJECTIVE: Rheumatoid Arthritis (RA) is a progressive autoimmune disease characterized by chronic joint inflammation and structural damage. Remission or at least low disease activity (LDA) represent potentially desirable goals of RA treatment. Single nucleotide polymorphisms (SNPs) in several genes might be useful for prediction of response to therapy. We aimed at exploring 4 SNPs in candidate genes (STAT4, PTPN2, PSORS1C1 and TRAF3IP2) in order to investigate their potential role in the response to therapy with tumor necrosis factor inhibitors (TNF-i) in RA patients...
2017: PloS One
https://www.readbyqxmd.com/read/28103850/acupuncture-for-primary-sj%C3%A3-gren-syndrome-pss-on-symptomatic-improvements-study-protocol-for-a-randomized-controlled-trial
#2
Quan Jiang, Huadong Zhang, Ran Pang, Jinzhou Chen, Zhishun Liu, Xinyao Zhou
BACKGROUND: Currently, feasible medical treatments are hitherto not satisfying to relieve pSS symptoms, which concerns numbers of clinical doctors. Acupuncture seems to be an alternative to treat pSS and conduces to good symptomatic results. However further research is necessary. This trial is to investigate the efficacy of acupuncture on improving the key symptoms of pSS, which are dryness, pain and fatigue (DPF). METHODS & DESIGN: The study is designed as a randomized controlled trial of two arms with a single centre...
January 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28096457/the-predictive-value-of-serum-s100a9-and-response-to-etanercept-is-not-confirmed-in-a-large-uk-rheumatoid-arthritis-cohort
#3
Samantha Louise Smith, Darren Plant, Stephen Eyre, Kimme Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Anne Barton
OBJECTIVE: The aim was to correlate protein concentrations of S100A9 in pretreatment serum samples with response to the tumour-necrosis factor (TNF) inhibitor drugs etanercept in a large UK replication cohort. METHODS: Pretreatment serum samples from patients with RA (n = 236) about to commence treatment with etanercept had S100A9 serum concentration measured using an ELISA. Following the experimental procedure, S100A9 concentrations were analysed with respect to EULAR response...
January 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28094753/quantifying-cutaneous-adverse-effects-of-systemic-glucocorticoids-in-patients-with-rheumatoid-arthritis-a-cross-sectional-cohort-study
#4
Jonna Amann, Anne-Marie Wessels, Friederike Breitenfeldt, Dörte Huscher, Johannes W J Bijlsma, Johannes W G Jacobs, Frank Buttgereit
OBJECTIVES: EULAR guidelines state that adverse effects (AEs) of glucocorticoid (GC) therapy should be considered and discussed with the patient before treatment is initiated. However, reliable quantitative data, especially on cutaneous AEs of low-to-medium dose GCs are lacking. We performed a study assessing the occurrence of cutaneous AEs of GCs and its association with current and cumulative GC doses in patients with rheumatoid arthritis (RA). METHODS: In a cross-sectional study performed in 2 outpatient rheumatology centres, 381 RA patients were enrolled...
January 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28089976/disease-characteristics-and-rheumatoid-arthritis-development-in-patients-with-early-undifferentiated-arthritis-a-2-year-followup-study
#5
Gina H Brinkmann, Ellen S Norli, Tore K Kvien, Anne J Haugen, Lars Grøvle, Halvor Nygaard, Olav Bjørneboe, Cathrine Thunem, Maria D Mjaavatten, Elisabeth Lie
OBJECTIVE: To examine the 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria. METHODS: Data were provided by the Norwegian Very Early Arthritis Clinic study, which included patients presenting with ≥ 1 swollen joint of ≤ 16 weeks' duration. UA was defined as patients not fulfilling the 2010 ACR/EULAR RA criteria and who did not have a clinical diagnosis other than RA at baseline...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089973/malignancies-in-patients-with-anti-rna-polymerase-iii-antibodies-and-systemic-sclerosis-analysis-of-the-eular-scleroderma-trials-and-research-cohort-and-possible-recommendations-for-screening
#6
Maria-Grazia Lazzaroni, Ilaria Cavazzana, Enrico Colombo, Rucsandra Dobrota, Jasmin Hernandez, Roger Hesselstrand, Cecilia Varju, Gabriella Nagy, Vanessa Smith, Paola Caramaschi, Valeria Riccieri, Eric Hachulla, Alexandra Balbir-Gurman, Emmanuel Chatelus, Katarzyna Romanowska-Próchnicka, Ana Carolina Araújo, Oliver Distler, Yannick Allanore, Paolo Airò
OBJECTIVE: To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients. METHODS: (1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089200/limitations-of-the-current-standards-of-care-for-treating-gout-and-crystal-deposition-in-the-primary-care-setting-a-review
#7
Robert T Keenan
PURPOSE: This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for gout based on the most current guidelines, opportunities for improving gout management, and current and emerging therapies for gout. METHODS: [PubMed and Google Scholar databases] were search for all articles and trials published before 2016, using the key terms [hyperuricemia, gout, tophi, joint erosion, joint damage, treatment guidelines, American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), flare, comorbidity, epidemiology, adherence, serum uric acid (sUA), monosodium urate (MSU), <6 mg/dL, MSU crystal formation, as well as individual drug names and classes of treatments of interest (allopurinol, febuxostat, colchicine, non-steroidal anti-inflammatories (NSAIDs)]...
January 11, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28088339/evidence-based-management-of-systemic-sclerosis-navigating-recommendations-and-guidelines
#8
REVIEW
Russell Edward Pellar, Janet Elizabeth Pope
OBJECTIVES: Systemic sclerosis (SSc) is a rare heterogeneous connective tissue disease. Recommendations addressing the major issues in the management of SSc including screening and treatment of organ complications are needed. METHODS: The updated European League Against Rheumatism/European Scleroderma Trial and Research (EULAR/EUSTAR) and the British Society of Rheumatology (BSR) and British Health Professionals in Rheumatology (BHPR) guidelines were compared and contrasted...
December 9, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28087505/2016-update-of-the-asas-eular-management-recommendations-for-axial-spondyloarthritis
#9
Désirée van der Heijde, Sofia Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pál Géher, Irene van der Horst-Bruinsma, Robert D Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compàn, Salih Ozgocmen, Fernando M Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Jürgen Braun
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) that were published since 2009...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28077693/new-grappa-and-eular-recommendations-for-the-management-of-psoriatic-arthritis-process-and-challenges-faced
#10
EDITORIAL
Laura C Coates, Laure Gossec, Sofia Ramiro, Philip Mease, Désirée van der Heijde, Josef S Smolen, Christopher Ritchlin, Arthur Kavanaugh
No abstract text is available yet for this article.
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064209/efficacy-and-effectiveness-of-tumour-necrosis-factor-inhibitors-in-the-treatment-of-rheumatoid-arthritis-in-randomized-controlled-trials-and-routine-clinical-practice
#11
Kalle J Aaltonen, Suvi Ylikylä, Jaana Tuulikki Joensuu, Pia Isomäki, Laura Pirilä, Markku Kauppi, Tuomas Rannio, Kari Eklund, Marja Blom, Dan Nordström
OBJECTIVE: Efficacy of TNF inhibitors in the treatment of RA assessed in randomized controlled trials (RCTs) may not be fully comparable to routine care owing to the stringent inclusion criteria. The objective of this study was to observe the effectiveness of TNF inhibitors in real-world patients and assess the patients' potential eligibility for the RCTs. METHODS: RA patients starting a TNF-inhibitor treatment between 2004 and 2014 were identified from the National Register for Biologic Treatment in Finland, which is a longitudinal observational cohort study...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28062384/timing-of-publication-of-abstracts-of-randomized-controlled-trials-presented-in-congresses-the-example-of-the-european-league-against-rheumatism-meeting
#12
Sylvain Mathieu, Gabriel Baron, Martin Soubrier, Philippe Ravaud
INTRODUCTION: The EUropean League Against Rheumatism (EULAR) congress is an important meeting to present abstracts of research in rheumatology. However, information in these abstracts is insufficient and must be followed and developed in a published article. This study aims to assess to what extent abstracts presented in the EULAR Meeting are published in journals. METHODS: We identified all abstracts of randomized controlled trials accepted for presentation at the EULAR annual meeting from 2002 to 2011...
January 3, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28053333/connective-tissue-disease-reflections-on-the-eular-recommendations-for-the-treatment-of-systemic-sclerosis
#13
Janet E Pope
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28034828/evidenced-based-guidelines-on-the-treatment-of-fibromyalgia-patients-are-they-consistent-and-if-not-why-not-have-effective-psychological-treatments-been-overlooked
#14
Kati Thieme, Marc Mathys, Dennis C Turk
: We compared the recommendations and methodology of several recent evidence-based guidelines for the management of patients with fibromyalgia (FM) published by professional organizations: 1. American Pain Society (APS) (2005) 2. Association of the Scientific Medical Societies in Germany (AWMF) (2012) 3. Canadian Pain Society (CPS, 2013), - Also used in United Kingdom and 4. European League Against Rheumatism (EULAR) (2016) Each guideline used systematic reviews and meta-analyses as highest level of evidence, APS, CPS, and AWMF also included individual randomized clinical trials (RCT)...
December 26, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28029551/recommendations-for-the-use-of-ultrasound-and-magnetic-resonance-in-patients-with-rheumatoid-arthritis
#15
Ingrid Möller, Estibaliz Loza, Jacqueline Uson, Carlos Acebes, Jose Luis Andreu, Enrique Batlle, Ángel Bueno, Paz Collado, Juan Manuel Fernández-Gallardo, Carlos González, Mercedes Jiménez Palop, María Pilar Lisbona, Pilar Macarrón, Joan Maymó, Jose Antonio Narváez, Victoria Navarro-Compán, Jesús Sanz, M Piedad Rosario, Esther Vicente, Esperanza Naredo
OBJECTIVE: To develop evidence-based recommendations on the use of ultrasound (US) and magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA). METHODS: Recommendations were generated following a nominal group technique. A panel of experts, consisting of 15 rheumatologists and 3 radiologists, was established in the first panel meeting to define the scope and purpose of the consensus document, as well as chapters, potential recommendations and systematic literature reviews (we used and updated those from previous EULAR documents)...
October 28, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/28012023/oral-to-subcutaneous-methotrexate-dose-conversion-strategy-in-the-treatment-of-rheumatoid-arthritis
#16
Michael H Schiff, Peter Sadowski
Both the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) guidelines recommend the use of methotrexate (MTX) for the treatment of rheumatoid arthritis (RA) when there is no contraindication. While MTX is the foundation of RA therapy (Singh et al. in Arthritis Care Res 64:625-639,2012), absorption saturation compromises its oral bioavailability (BA). Differences in the relative BA of oral versus subcutaneous (SC) MTX demonstrate the need for guidance on successful dose-conversion strategies...
December 23, 2016: Rheumatology International
https://www.readbyqxmd.com/read/28010883/effectiveness-and-drug-survival-of-tnf-inhibitors-in-the-treatment-of-psoriatic-arthritis-a-prospective-cohort-study
#17
Kalle Aaltonen, Arto Heinonen, Jaana Joensuu, Pinja Parmanne, Anna Karjalainen, Tuire Varjolahti-Lehtinen, Toini Uutela, Maija Puurtinen-Vilkki, Leena Arstila, Marja Blom, Tuulikki Sokka, Dan Nordström
BACKGROUND AND OBJECTIVES: Tumor necrosis factor (TNF)-inhibitors are used to treat psoriatic arthritis (PsA), but only a limited number of observational studies on this subject have been published thus far. The aim of this research was to analyze the effectiveness and drug survival of TNF-inhibitors in the treatment of PsA. METHODS: PsA patients identified from the National Register for Biologic Treatment in Finland (ROB-FIN) starting their first, second, or third TNF-inhibitor treatment between 2004 and 2014 were included...
September 16, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28007756/eular-efort-recommendations-for-management-of-patients-older-than-50%C3%A2-years-with-a-fragility-fracture-and-prevention-of-subsequent-fractures
#18
W F Lems, K E Dreinhöfer, H Bischoff-Ferrari, M Blauth, E Czerwinski, Jap da Silva, A Herrera, P Hoffmeyer, T Kvien, G Maalouf, D Marsh, J Puget, W Puhl, G Poor, L Rasch, C Roux, S Schüler, B Seriolo, U Tarantino, T van Geel, A Woolf, C Wyers, P Geusens
The European League Against Rheumatism (EULAR) and the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) have recognised the importance of optimal acute care for the patients aged 50 years and over with a recent fragility fracture and the prevention of subsequent fractures in high-risk patients, which can be facilitated by close collaboration between orthopaedic surgeons and rheumatologists or other metabolic bone experts. Therefore, the aim was to establish for the first time collaborative recommendations for these patients...
December 22, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27992693/scleroderma-peripheral-b-lymphocytes-secrete-interleukin-6-and-tgf-%C3%AE-and-activate-fibroblasts
#19
Nicolas Dumoitier, Benjamin Chaigne, Alexis Régent, Sébastien Lofek, Maïssa Mhibik, Peter Dorfmüller, Benjamin Terrier, Jonathan London, Alice Bérezné, Nicolas Tamas, Nadine Varin-Blank, Luc Mouthon
OBJECTIVE: To study the role of B lymphocytes in systemic sclerosis (SSc). PATIENTS AND METHODS: Peripheral B cell subpopulations, interleukin 6 (IL-6) and transforming growth factor-beta (TGF-β) productions were analyzed using flow cytometry and multiplex assay. Fibroblasts proliferation rate upon incubation with supernatants of B cells isolated from SSc patients or healthy controls (HC) was assessed using XTT, BrdU and Ki67. Collagen production was assessed using a collagen assay...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27991858/eular-definition-of-arthralgia-suspicious-for-progression-to-rheumatoid-arthritis
#20
Hanna W van Steenbergen, Daniel Aletaha, Liesbeth J J Beaart-van de Voorde, Elisabeth Brouwer, Catalin Codreanu, Bernard Combe, João E Fonseca, Merete L Hetland, Frances Humby, Tore K Kvien, Karin Niedermann, Laura Nuño, Sue Oliver, Solbritt Rantapää-Dahlqvist, Karim Raza, Dirkjan van Schaardenburg, Georg Schett, Liesbeth De Smet, Gabriella Szücs, Jirí Vencovský, Piotr Wiland, Maarten de Wit, Robert L Landewé, Annette H M van der Helm-van Mil
BACKGROUND: During the transition to rheumatoid arthritis (RA) many patients pass through a phase characterised by the presence of symptoms without clinically apparent synovitis. These symptoms are not well-characterised. This taskforce aimed to define the clinical characteristics of patients with arthralgia who are considered at risk for RA by experts based on their clinical experience. METHODS: The taskforce consisted of 18 rheumatologists, 1 methodologist, 2 patients, 3 health professionals and 1 research fellow...
October 6, 2016: Annals of the Rheumatic Diseases
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