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https://www.readbyqxmd.com/read/29237618/efficacy-and-safety-of-adrenocorticotropic-hormone-gel-in-refractory-dermatomyositis-and-polymyositis
#1
Rohit Aggarwal, Galina Marder, Diane Carol Koontz, Preeya Nandkumar, Zengbiao Qi, Chester V Oddis
AIM: To evaluate the efficacy, safety, tolerability and steroid-sparing effect of repository corticotropin injection (RCI), in an open-label clinical trial, in refractory adult polymyositis (PM) and dermatomyositis (DM). METHODS: Adults with refractory PM and DM were enrolled by two centres. Inclusion criteria included refractory disease defined as failing glucocorticoid and/or ≥1 immunosuppressive agent, as well as active disease defined as significant muscle weakness and >2 additional abnormal core set measures (CSMs) or a cutaneous 10 cm Visual Analogue Scale score of ≥3 cm and at least three other abnormal CSMs...
December 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29234876/-emeunet-the-emerging-eular-network
#2
J Mucke, J Leipe
No abstract text is available yet for this article.
December 12, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29233833/scoring-hypoechogenic-areas-in-one-parotid-and-one-submandibular-gland-increases-feasibility-of-ultrasound-in-primary-sj%C3%A3-gren-s-syndrome
#3
Esther Mossel, Suzanne Arends, Jolien F van Nimwegen, Konstantina Delli, Alja J Stel, Frans G M Kroese, Fred K L Spijkervet, Arjan Vissink, Hendrika Bootsma
OBJECTIVE: To assess whether ultrasonographic scoring of (i) both parotid and submandibular salivary glands and (ii) all individual components of the Hocevar scoring system, is needed for classifying patients as primary Sjögren's syndrome (pSS). METHODS: Ultrasound examination of the major salivary glands (sUS) was performed in 204 consecutive patients clinically suspected (n=171) or diagnosed (n=33) with pSS.Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and salivary gland posterior border were scored in left and right parotid and submandibular glands...
December 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29233691/enthesopathy-in-rheumatoid-arthritis-and-spondyloarthritis-an-ultrasound-study
#4
Esther Ebstein, Baptiste Coustet, Vanina Masson-Behar, Marine Forien, Elisabeth Palazzo, Philippe Dieudé, Sébastien Ottaviani
OBJECTIVE: We aimed to compare the prevalence of enthesopathy seen on ultrasonography (US) in spondyloarthritis (SpA) and rheumatoid arthritis (RA) and compared it to healthy controls. METHODS: All included patients with RA (2010 ACR/EULAR criteria) and SpA (ASAS criteria) and healthy controls underwent clinical and US evaluation of enthesis at seven sites (quadriceps, proximal and distal patellar, Achilles and triceps tendons, plantar aponeurosis and lateral epicondyle enthesis)...
December 9, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29226727/high-expression-of-interleukine-1-receptor-antagonist-in-rheumatoid-arthritis-association-with-il1rn-2-2-genotype
#5
S Ramírez-Pérez, U De la Cruz-Mosso, J Hernández-Bello, G E Martínez-Bonilla, M G Ramírez-Dueñas, A L Pereira-Suárez, I Parra Rojas, E Martínez-López, J Macías-Barragán, J F Muñoz-Valle
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra is an anti-inflammatory cytokine codified by IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in IL1RN gene has been associated with RA risk and regulation of IL-1Ra expression. In this study, we determined mRNA and protein expression of IL-1Ra in RA patients and control subjects (CS). This study included 85 RA patients classified according to the ACR/EULAR 2010 criteria and 67 CS...
December 2017: Autoimmunity
https://www.readbyqxmd.com/read/29225918/correction-efficacy-and-safety-of-non-pharmacological-and-non-biological-pharmacological-treatment-a-systematic-literature-review-informing-the-2016-update-of-the-asas-eular-recommendations-for-the-management-of-axial-spondyloarthritis
#6
(no author information available yet)
[This corrects the article DOI: 10.1136/rmdopen-2016-000397.][This corrects the article DOI: 10.1136/rmdopen-2016-000397.].
2017: RMD Open
https://www.readbyqxmd.com/read/29208023/comparison-of-2002-aecg-and-2016-acr-eular-classification-criteria-and-added-value-of-salivary-gland-ultrasonography-in-a-patient-cohort-with-suspected-primary-sj%C3%A3-gren-s-syndrome
#7
Maëlle Le Goff, Divi Cornec, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Rozenn Le Berre, Steeve Genestet, Béatrice Cochener, Sylvie Boisrame-Gastrin, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec
BACKGROUND: The objective was to evaluate concordance between 2002 American-European Consensus Group (AECG) and 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (pSS) and to assess how salivary gland ultrasonography (SGUS) might improve the classification of patients. METHODS: Patients with suspected pSS underwent a standardised evaluation, including SGUS, at inclusion into the single-centre Brittany DIApSS cohort...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29207757/vitamin-d-levels-and-associations-in-indian-patients-with-primary-sj%C3%A3-gren-s-syndrome
#8
Pulukool Sandhya, Gowri Mahasampath, Puneet Mashru, Joseph Dian Bondu, Victoria Job, Debashish Danda
Introduction: Vitamin D is a steroid hormone belonging to the class of secosteroids with myriad immune functions and has been implicated in aetiopathogenesis of various autoimmune diseases. Although, there have been various studies showing the association of vitamin D in rheumatoid arthritis and lupus in different populations, there have been limited studies on vitamin D and primary Sjögren's Syndrome (pSS). There are no studies on association of vitamin D and pSS from any tropical country including Indian subcontinent...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204974/effects-of-discontinuation-of-urate-lowering-therapy-a-systematic-review
#9
Virginie Beslon, Perrine Moreau, Annabel Maruani, Hubert Maisonneuve, Bruno Giraudeau, Jean-Pascal Fournier
BACKGROUND: Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse. METHODS: We conducted a systematic literature review of clinical studies investigating the effect of discontinuing any ULT (allopurinol, febuxostat, probenecid, sulfinpyrazone, benzbromarone) in adults on long-term therapy...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29204859/improvement-in-diagnosis-and-treat-to-target-management-of-hyperuricemia-in-gout-results-from-the-gema-2-transversal-study-on-practice
#10
Fernando Perez Ruiz, Carlos A Sanchez-Piedra, Jesus T Sanchez-Costa, Mariano Andrés, Cesar Diaz-Torne, Mercedes Jimenez-Palop, Eugenio De Miguel, Carmen Moragues, Francisca Sivera
INTRODUCTION: The objective of the study was to evaluate changes regarding main European League Against Rheumatism (EULAR) recommendations on diagnosis and treatment of gout compared to a previous assessment. METHODS: The GEMA-2 (Gout Evaluation and MAnagement) is a transversal assessment of practice for gout by rheumatologists. Main outcome variables were improvement of the previous GEMA assessment regarding the rate of crystal-proven diagnosis and that reaching therapeutic serum urate target below 6 mg/dl at last visit...
December 4, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29195002/validation-of-classification-criteria-of-macrophage-activation-syndrome-in-japanese-patients-with-systemic-juvenile-idiopathic-arthritis
#11
Masaki Shimizu, Mao Mizuta, Takahiro Yasumi, Naomi Iwata, Yuka Okura, Noriko Kinjo, Hiroaki Umebayashi, Tomohiro Kubota, Yasuo Nakagishi, Kenichi Nishimura, Masato Yashiro, Junko Yasumura, Kazuko Yamazaki, Hiroyuki Wakiguchi, Nami Okamoto, Masaaki Mori
OBJECTIVE: To validate whether the 2016 ACR/EULAR classification criteria of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA) is practical in the real world. METHODS: A combination of expert consensus and analysis of real patient data was conducted by a panel of 15 paediatric rheumatologists. Sixty five profiles comprised 18 patients with s-JIA-associated MAS and 47 patients with active s-JIA without evidence of MAS...
December 1, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29187009/ixekizumab-an-anti-il-17a-monoclonal-antibody-for-the-treatment-of-psoriatic-arthritis
#12
Eric Toussirot
Psoriatic arthritis (PsA) is an inflammatory rheumatic disease that manifests itself with synovitis, dactylitis, enthesitis and also axial involvement. Interleukin-17A has been identified as a master cytokine in the inflammatory response and pathogenesis of PsA and spondyloarthritis in general. Ixekizumab is a new humanized monoclonal antibody that blocks the biological activity of IL-17A. This biological agent has previously demonstrated a high level of efficacy in psoriasis. Areas covered: This review discusses the basic immunology of the IL-17 cytokine family, the contribution of IL-17A to the immunopathogenesis of PsA, the clinical trials that evaluated ixekizumab in patients with PsA (SPIRIT program) and the safety of this agent...
November 29, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29185957/the-utility-of-the-acr-eular-2017-provisional-classification-criteria-for-granulomatosis-with-polyangiitis-in-korean-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#13
Juyoung Yoo, Ho Jae Kim, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We applied the ACR/EULAR 2017 provisional classification criteria for granulomatosis with polyangiitis (GPA) to 150 Korean patients with previously diagnosed antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and investigated how many patients with AAV were reclassified as GPA. METHODS: We included patients with 30 GPA, 30 eosinophilic GPA (EGPA) and 90 microscopic polyangiitis (MPA) patients. Patients can be classified as GPA, when the sum of scores is more than 5...
November 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29183347/the-effect-of-an-intensive-smoking-cessation-intervention-on-disease-activity-in-patients-with-rheumatoid-arthritis-study-protocol-for-a-randomised-controlled-trial
#14
Ida Kristiane Roelsgaard, Thordis Thomsen, Mikkel Østergaard, Robin Christensen, Merete Lund Hetland, Søren Jacobsen, Lena Andersen, Hanne Tønnesen, Silvia Rollefstad, Anne Grete Semb, Bente Appel Esbensen
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, inflammatory rheumatic disease with the potential to induce significant disability. Patients with RA are at increased risk of cardiovascular diseases (CVD). Smokers with RA tend to experience more pain and fatigue, higher disease activity, more erosive joint destruction and a lower health-related quality of life (HR-QoL) than non-smokers. It remains to be determined whether these effects can be reduced by smoking cessation. This randomised controlled trial (RCT) in patients with RA aims to examine the effect of intensive smoking cessation intervention (motivational counselling combined with tailored nicotine replacement therapy) versus standard care on smoking cessation, and consequently on disease activity...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29177081/impact-of-gender-on-the-response-and-tolerance-to-abatacept-in-patients-with-rheumatoid-arthritis-results-from-the-ora-registry
#15
Cynthia Nourisson, Martin Soubrier, Aurélien Mulliez, Athan Baillet, Thomas Bardin, Alain Cantagrel, Bernard Combe, Maxime Dougados, René-Marc Flipo, Thierry Schaeverbeke, Jean Sibilia, Olivier Vittecoq, Philippe Ravaud, Jacques-Eric Gottenberg, Xavier Mariette, Anne Tournadre
Objective: The impact of gender on the response and tolerance to abatacept was assessed in a large prospective cohort during 2 years of follow-up. Methods: From the 1017 patients included in the Orencia and Rheumatoid Arthritis registry, disease activity was assessed at baseline, 6, 12 and 24 months. The relationship between the European League Against Rheumatism (EULAR) response, Disease Activity Score 28 (DAS28) remission, rate of adverse events and gender was explored in multivariate analysis...
2017: RMD Open
https://www.readbyqxmd.com/read/29177080/eular-acr-classification-criteria-for-adult-and-juvenile-idiopathic-inflammatory-myopathies-and-their-major-subgroups-a-methodology-report
#16
Matteo Bottai, Anna Tjärnlund, Giola Santoni, Victoria P Werth, Clarissa Pilkington, Marianne de Visser, Lars Alfredsson, Anthony A Amato, Richard J Barohn, Matthew H Liang, Jasvinder A Singh, Rohit Aggarwal, Snjolaug Arnardottir, Hector Chinoy, Robert G Cooper, Katalin Danko, Mazen M Dimachkie, Brian M Feldman, Ignacio García-De La Torre, Patrick Gordon, Taichi Hayashi, James D Katz, Hitoshi Kohsaka, Peter A Lachenbruch, Bianca A Lang, Yuhui Li, Chester V Oddis, Marzena Olesinka, Ann M Reed, Lidia Rutkowska-Sak, Helga Sanner, Albert Selva-O'Callaghan, Yeong Wook Song, Jiri Vencovsky, Steven R Ytterberg, Frederick W Miller, Lisa G Rider, Ingrid E Lundberg
Objective: To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods: An international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Rheumatology, dermatology, neurology and paediatric clinics worldwide collected data on 976 IIM cases (74% adults, 26% children) and 624 non-IIM comparator cases with mimicking conditions (82% adults, 18% children)...
2017: RMD Open
https://www.readbyqxmd.com/read/29167154/implementation-of-the-eular-cardiovascular-risk-management-guideline-in-patients-with-rheumatoid-arthritis-results-of-a-successful-collaboration-between-primary-and-secondary-care
#17
EDITORIAL
Julia M Weijers, Sanne A A Rongen-van Dartel, Dan M G M F Hoevenaars, Max Rubens, Marlies E J L Hulscher, Piet L C M van Riel
The updated European League Against Rheumatism (EULAR) guideline recommends cardiovascular disease (CVD) risk assessment at least once every 5 years in all patients with rheumatoid arthritis (RA). This viewpoint starts with a literature overview of studies that investigated the level of CVD risk factor (CVD-RF) screening in patients with RA in general practices or in outpatient clinics. These studies indicate that CVD-RF screening in patients with RA is marginally applied in clinical practice, in primary as well as secondary care...
November 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29166923/childhood-takayasu-arteritis-disease-course-and-response-to-therapy
#18
Florence A Aeschlimann, Simon W M Eng, Shehla Sheikh, Ronald M Laxer, Diane Hebert, Damien Noone, Marinka Twilt, Christian Pagnoux, Susanne M Benseler, Rae S M Yeung
BACKGROUND: Takayasu arteritis (TAK) is a large vessel vasculitis that rarely affects children. Data on childhood TAK are scarce. The aim of this study was to analyze the presenting features, course and outcome of children with TAK, compare efficacy of treatment regimens and identify high-risk factors for adverse outcome. METHODS: A single-center cohort study of consecutive children fulfilling the EULAR/PRINTO/PReS criteria for childhood TAK between 1986 and 2015 was performed...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29165607/an-evidence-based-approach-to-pre-pregnancy-counselling-for-patients-with-systemic-lupus-erythematosus
#19
Y K Onno Teng, Edwin O W Bredewold, Ton J Rabelink, Tom W J Huizinga, H C Jeroen Eikenboom, Maarten Limper, Ruth D E Fritsch-Stork, Kitty W M Bloemenkamp, Marieke Sueters
Patients with SLE are often young females of childbearing age and a pregnancy wish in this patient group is common. However, SLE patients are at high risk for adverse pregnancy outcomes that require adequate guidance. It is widely acknowledged that pre-pregnancy counselling is the pivotal first step in the management of SLE patients with a wish to become pregnant. Next, management of these patients is usually multidisciplinary and often requires specific expertise from the different physicians involved. Very recently a EULAR recommendation was published emphasizing the need for adequate preconception counselling and risk stratification...
November 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/29157669/the-combination-of-il-6-and-its-soluble-receptor-is-associated-with-the-response-of-rheumatoid-arthritis-patients-to-tocilizumab
#20
Cesar Diaz-Torne, Maria Dels Angels Ortiz, Patricia Moya, Maria Victoria Hernandez, Delia Reina, Ivan Castellvi, Juan Jose De Agustin, Diana de la Fuente, Hector Corominas, Raimon Sanmarti, Carlos Zamora, Elisabet Cantó, Silvia Vidal
BACKGROUND: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. We aimed to combine IL-6 and soluble IL-6R (sIL-6R) levels to identify groups of responses. METHODS: Heparinized blood and clinical data from 63 RA patients were collected before treatment and after 3 and 6 months...
November 17, 2017: Seminars in Arthritis and Rheumatism
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