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https://www.readbyqxmd.com/read/29657832/predictive-value-of-serum-calprotectin-s100a8-a9-for-clinical-response-after-starting-or-tapering-anti-tnf-treatment-in-patients-with-rheumatoid-arthritis
#1
Lieke Tweehuysen, Nathan den Broeder, Noortje van Herwaarden, Leo A B Joosten, Peter L van Lent, Thomas Vogl, Frank H J van den Hoogen, Rogier M Thurlings, Alfons A den Broeder
Objectives: Calprotectin (S100A8/A9) has been correlated with disease activity in rheumatoid arthritis (RA). The aim of this study was to investigate the predictive value of serum calprotectin for clinical response after starting and tapering anti-tumour necrosis factor treatment in RA. Methods: Serum samples and clinical outcomes were derived from two longitudinal RA studies.At baseline (starting or tapering of adalimumab or etanercept), calprotectin levels were determined by ELISA...
2018: RMD Open
https://www.readbyqxmd.com/read/29655640/how-are-ocular-signs-and-symptoms-of-dry-eye-associated-with-depression-in-women-with-and-without-sj%C3%A3-gren-s-syndrome
#2
John A Gonzales, Annie Chou, Jennifer R Rose-Nussbaumer, Vatinee Y Bunya, Lindsey A Criswell, Caroline H Shiboski, Thomas M Lietman
PURPOSE: To determine whether ocular phenotypic features of keratoconjunctivitis sicca (KCS) and/or participant-reported symptoms of dry eye disease are associated with depression in women participants enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA). DESIGN: Cross-sectional study. METHODS: Women enrolled in the SICCA registry from 9 international research sites. Participants met at least one of five inclusion criteria for registry enrollment (including complaints of dry eyes or dry mouth, a previous diagnosis of Sjögren's syndrome (SS), abnormal serology (positive anti-Sjögren's syndrome-related antigen A and/or B (anti-SSA and/or anti-SSB), or elevated anti-nuclear antibody and rheumatoid factor), bilateral parotid gland enlargement, or multiple dental caries)...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29652792/influence-of-blue-mussel-mytilus-edulis-intake-on-disease-activity-in-female-patients-with-rheumatoid-arthritis-the-mira-randomized-cross-over-dietary-intervention
#3
Helen M Lindqvist, Inger Gjertsson, Tove Eneljung, Anna Winkvist
Rheumatoid Arthritis (RA) is a chronic inflammatory disease. This study evaluates the effect of blue mussel intake on disease activity and quality of life in women with RA. Thirty-nine women with established RA and a disease activity score 28 (DAS28) >3.0 were recruited to a randomized 2 × 11-week cross-over dietary intervention. The participants continued with their medication and habitual diet and exchanged one cooked meal a day, five days a week, with a meal including 75 g blue mussels or 75 g meat...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29625968/2018-update-of-the-eular-recommendations-for-the-management-of-beh%C3%A3-et-s-syndrome
#4
Gulen Hatemi, Robin Christensen, Dongsik Bang, Bahram Bodaghi, Aykut Ferhat Celik, Farida Fortune, Julien Gaudric, Ahmet Gul, Ina Kötter, Pietro Leccese, Alfred Mahr, Robert Moots, Yesim Ozguler, Jutta Richter, David Saadoun, Carlo Salvarani, Francesco Scuderi, Petros P Sfikakis, Aksel Siva, Miles Stanford, Ilknur Tugal-Tutkun, Richard West, Sebahattin Yurdakul, Ignazio Olivieri, Hasan Yazici
Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search...
April 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29624878/elastographic-ultrasound-an-additional-image-tool-in-sj%C3%A3-gren-s-syndrome
#5
Eric Kimura-Hayama, Sergio Criales-Vera, Luis Azpeitia-Espinosa, Carlos Pacheco-Molina, Edgardo Reyes, Guadalupe Lima, Diego Hernandez-Ramirez, Luis Llorente, Gabriela Hernandez-Molina
AIM: To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B-mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis. METHODS: We performed B-mode and elastography ultrasound of major salivary glands of 26 patients with primary Sjögren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29624625/clinical-management-of-seronegative-and-seropositive-rheumatoid-arthritis-a-comparative-study
#6
Sang-Tae Choi, Kwang-Hoon Lee
Both rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are associated with poor radiologic outcomes in patients with rheumatoid arthritis (RA). In general, RA patients positive for RF or ACPA (SPRA) are considered to manifest an aggressive disease course compared with seronegative RA patients (SNRA). However, the relationship between seropositivity and measures of disease severity other than radiologic outcome is disputed. In this study, we sought to compare the clinical presentations and treatment outcomes of SNRA and SPRA patients...
2018: PloS One
https://www.readbyqxmd.com/read/29623391/association-between-memory-b-cells-and-clinical-and-immunological-features-of-primary-sj%C3%A3-gren-s-syndrome-and-sicca-patients
#7
Filipe Barcelos, Catarina Martins, Ana Papoila, Carlos Geraldes, Joana Cardigos, Glória Nunes, Teresa Lopes, Nuno Alves, José Vaz-Patto, Jaime Branco, Luís-Miguel Borrego
B-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29...
April 6, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29618136/the-role-of-ultrasound-defined-tenosynovitis-and-synovitis-in-the-prediction-of-rheumatoid-arthritis-development
#8
Ilfita Sahbudin, Luke Pickup, Peter Nightingale, Gina Allen, Zaeem Cader, Ruchir Singh, Paola de Pablo, Christopher D Buckley, Karim Raza, Andrew Filer
Objectives: Tenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS in predicting RA development is unclear. We assessed the predictive utility of US-defined TS alongside US-defined synovitis and clinical and serological variables in a prospective cohort of early arthritis patients. Methods: One hundred and seven patients with clinically apparent synovitis of one or more joint and symptom duration ⩽3 months underwent baseline clinical, laboratory and US assessment of 19 bilateral joint sites and 16 bilateral tendon compartments...
April 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29616658/-gout-a-treatable-condition
#9
Gudrun Arna Johannsdottir, Olafur Palsson, Helgi Jonsson, Bjorn Gudbjornsson
Gout is a disabling and common arthritis with increasing prevalence. Without treatment the disease can cause permanent joint damage. It is commonly associated with the metabolic syndrome but can also be related to a number of life-threatening diseases and their treatments. Gout is often misdiagnosed and its long-term management is suboptimal despite the availability of effective treatments. Recently The American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) released common guidelines for the diagnosis of gout and EULAR updated their guidelines for management...
April 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29614092/combined-classification-system-based-on-acr-eular-and-ultrasonographic-scores-for-improving-the-diagnosis-of-sj%C3%A3-gren-s-syndrome
#10
Yukinori Takagi, Hideki Nakamura, Misa Sumi, Toshimasa Shimizu, Yasuko Hirai, Yoshiro Horai, Ayuko Takatani, Atsushi Kawakami, Sato Eida, Miho Sasaki, Takashi Nakamura
We retrospectively evaluated the effectiveness of combined use of salivary gland ultrasonography (US) and the 2016 American College of Rheumatology/European League Against Rheumatic Disease (ACR/EULAR) classification criteria for improving the diagnostic efficiency in patients with Sjögren's syndrome (SS). A US-based salivary gland disease grading system was developed using a cohort comprising 213 SS or non-SS patients who fulfilled the minimum requirements for classifying SS based on the American-European Consensus Group (AECG) and ACR criteria...
2018: PloS One
https://www.readbyqxmd.com/read/29611083/regional-differences-in-baseline-disease-activity-and-remission-rates-following-golimumab-treatment-for-ra-results-from-the-go-more-trial
#11
Patrick Durez, Karel Pavelka, Maria Alicia Lazaro, Abraham Garcia-Kutzbach, Robert J Moots, Howard Amital, Marinella Govoni, Nathan Vastesaeger
GO-MORE (NCT00975130) was a large open-label, multinational, multicenter, prospective phase 3 trial evaluating add-on therapy with golimumab in biologic-naïve patients with active rheumatoid arthritis (RA). The objective of this post hoc analysis was to examine regional differences in baseline disease activity and remission rates following golimumab treatment for RA. This was a planned, descriptive post hoc analysis of data from the GO-MORE trial. Baseline disease activity and remission were defined as moderate or severe based on EULAR criteria...
April 2, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29608774/b-cell-activity-markers-are-associated-with-different-disease-activity-domains-in-primary-sj%C3%A3-gren-s-syndrome
#12
Katherine James, Chimwemwe Chipeta, Antony Parker, Stephen Harding, Simon J Cockell, Colin S Gillespie, Jennifer Hallinan, Francesca Barone, Simon J Bowman, Wan-Fai Ng, Benjamin A Fisher
Objectives: B-cell activating factor (BAFF), β-2 microglobulin (β2M) and serum free light chains (FLCs) are elevated in primary SS (pSS) and associated with disease activity. We aimed to investigate their association with the individual disease activity domains of the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) in a large well-characterized pSS cohort. Methods: Sera from pSS patients enrolled in the UK Primary Sjögren's Syndrome Registry (UKPSSR) (n = 553) and healthy controls (n = 286) were analysed for FLC (κ and λ), BAFF and β2 M...
March 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29606667/origins-of-discordant-responses-among-3-rheumatoid-arthritis-improvement-criteria
#13
Michael M Ward, Lori C Guthrie, Maria I Alba, Abhijit Dasgupta
OBJECTIVE: We examined agreement between the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), and Simplified Disease Activity Index (SDAI) response criteria in rheumatoid arthritis (RA) and tested whether discordant responses were associated with patients' baseline characteristics or changes in RA activity encapsulated by the different criteria. METHODS: In a prospective longitudinal study, we examined responses of 243 patients with active RA to escalation of antirheumatic treatment...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29606664/rheumatoid-arthritis-magnetic-resonance-imaging-score-predicts-therapy-response-results-of-the-german-arthromark-cohort
#14
Philipp Sewerin, Lien Le, Stefan Vordenbäumen, Christoph Schleich, Ruben Sengewein, Ralph Brinks, Georg Pongratz, Ellen Bleck, Juliane Lesch, Ulrich Mansmann, Matthias Schneider, Benedikt Ostendorf
OBJECTIVE: Markers for treatment response in rheumatoid arthritis (RA) are lacking. The aim of the study was to assess the performance of the RA magnetic resonance imaging (MRI) scoring system (RAMRIS) in combination with serum biomarkers to predict response to methotrexate (MTX) treatment in therapy-naive patients with early RA by using high-field MRI. METHODS: Twenty-eight patients with RA were prospectively assessed with baseline 3-T MRI of the clinical dominant hand, 3 and 6 months after MTX...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29604186/the-clinical-efficacy-and-safety-of-baminercept-a-lymphotoxin-%C3%AE-receptor-fusion-protein-in-primary-sj%C3%A3-gren-s-syndrome-results-from-a-randomized-double-blind-placebo-controlled-phase-ii-trial
#15
E William St Clair, Alan N Baer, Chungwen Wei, Ghaith Noaiseh, Anne Parke, Andreea Coca, Tammy O Utset, Mark C Genovese, Daniel J Wallace, James McNamara, Karen Boyle, Lynette Keyes-Elstein, Jeffrey L Browning, Nathalie Franchimont, Kira Smith, Joel M Guthridge, Ignacio Sanz, Judith A James
OBJECTIVE: To evaluate the clinical efficacy and safety of baminercept, a lymphotoxin β receptor IgG fusion protein (LTβR-Ig), for the treatment of primary Sjögren's syndrome (SS) and explore its possible mechanisms of action. METHODS: In this multicenter trial, 52 patients with primary SS were randomized in a 2:1 ratio to receive subcutaneous injections of 100 mg of baminercept every week for 24 weeks or matching placebo. The primary endpoint was the change between screening and week 24 in stimulated whole salivary flow (SWSF)...
March 31, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29600939/chinese-registry-of-rheumatoid-arthritis-credit-introduction-and-prevalence-of-remission-in-chinese-patients-with-rheumatoid-arthritis
#16
Chen Yu, Mengtao Li, Xinwang Duan, Yongfei Fang, Qin Li, Rui Wu, Shengyun Liu, Yongfu Wang, Zhenbiao Wu, Xiaofei Shi, Zhenyu Jiang, Yanhong Wang, Evelyn D Hsieh, Shangyi Jin, Nan Jiang, Qian Wang, Yan Zhao, Xinping Tian, Xiaofeng Zeng
OBJECTIVES: To introduce the Chinese Registry of rhEumatoiD arthrITis (CREDIT), which is the first nationwide, multicentre, online rheumatoid arthritis (RA) registry in China, and to depict major cross-sectional data and treatment strategies of Chinese RA patients. METHODS: RA patients who fulfilled the 2010 ACR/EULAR classification criteria for rheumatoid arthritis were recruited into the registry by their rheumatologists from 144 clinical centres in China. Data, including demographics, disease characteristics, co-morbidities, treatment, and adverse reactions, were collected and documented through the predefined protocol...
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29595284/-treat-to-target-in-gouty-arthritis
#17
Karel Pavelka
Gout is a crystal-induced, metabolically determined inflammatory rheumatic disease with increasing prevalence. In clinical practice, gout causes frequent diagnostic as well as therapeutic problems. The golden diagnostic standard is crystalographic analysis and evidence of monosodium urate crystals in the polarization microscope; if this is not available, the diagnosis can be established through a combination of clinical, laboratory and imaging techniques. The acute gouty attack must be treated by quick administration of anti-inflammatory medicines, with available alternatives being nonsteroidal antirheumatic drugs (NSA), colchicine and glucocorticoids...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29595283/-polymyalgia-rheumatica
#18
Petr Němec, Andrea Šprláková-Puková, Zdeněk Řehák
Polymyalgia rheumatica is the most frequent inflammatory disease of people over 50 years of age. It mainly affects the Caucasian race and roughly 2-3 times as many women. From the viewpoint of etiology, polymyalgia rheumatica is a complex disease. Involved in its origin is genetic predisposition, factors of age and outer environment. 16-21 % of patients with polymyalgia rheumatica may at the same time have symptoms of giant cell arteritis. Diagnosis is made primarily on the basis of clinical symptoms and it is supported by the presence of laboratory signs of inflammation...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29589399/contribution-of-the-new-2012-eular-acr-classification-criteria-for-the-diagnosis-of-polymyalgia-rheumatica
#19
F Muratore, C Salvarani, P Macchioni
Polymyalgia rheumatica (PMR) is one of the most common rheumatic inflammatory disorders in people aged over 50. It is characterized by aching and prolonged morning stiffness in the shoulder and pelvic girdles and neck. To date there are no specific diagnostic tests, and in clinical practice the diagnosis of PMR remains based on its characteristic clinical manifestations, laboratory evidence of systemic inflammation, rapid response to low doses of glucocorticoids and exclusion of other disorders that may present with proximal pain and stiffness...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29589397/perspectives-and-unmet-needs-in-polymyalgia-rheumatica-providing-the-fundamental-framework-for-the-development-of-new-treatment-regimes-in-polymyalgia-rheumatica
#20
B D Nielsen, B Dasgupta
Polymyalgia rheumatica is effectively treated with glucocorticoids. However, glucocorticoid treatment can cause numerous and potentially serious side effects. Therefore, lowest effective dose and shortest duration to control disease is aimed for and glucocorticoid-sparing treatments are needed. Nevertheless, development of treatment regimens in PMR has been hampered by the lack of reliable classification criteria and evidence-based outcome measures. In this editorial, we discuss the need for valid classification criteria in PMR, the strengths and limitations of the ACR/EULAR 2012 provisional classification criteria for PMR and the need of validation and possible refining of the criteria...
March 27, 2018: Reumatismo
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