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high grade squamous intraepithelial lesion

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https://www.readbyqxmd.com/read/28720474/nitrous-oxide-cryotherapy-for-treatment-of-esophageal-squamous-cell-neoplasia-initial-multicenter-international-experience-with-a-novel-portable-cryoballoon-ablation-system-with-video
#1
Marcia Irene Canto, Julian Abrams, Hannah Kunzli, Bas Weusten, Yoshihiro Komatsu, Blair Jobe, Charles J Lightdale
BACKGROUND AND AIMS: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or radiofrequency ablation (RFA). A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system (CbFAS) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon...
July 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28720449/human-papillomavirus-in-anal-biopsy-tissues-and-liquid-based-cytology-samples-of-hiv-positive-and-hiv-negative-thai-men-who-have-sex-with-men
#2
Tippawan Pankam, Stephen J Kerr, Nipat Teeratakulpisan, Piyanee Rodbamrung, Rapeeporn Wongkanya, Somboon Keelawat, Komkrit Ruangritchankul, Piranun Hongchookiat, Ramida Watanapokasin, Nittaya Phanuphak
BACKGROUND: Men who have sex with men (MSM) are at high risk of developing human papillomavirus (HPV)-related anal cancer. We compared HPV genotypes in anal tissues (Bx) and anal liquid-based cytology fluid (LBC) from HIV-positive and HIV-negative MSM. METHODS: Bx (32 normal, 41 low-grade squamous intraepithelial lesions (LSIL) and 22 high-grade squamous intraepithelial lesions (HSIL)), along with LBC from the same visit, were selected from 61 HIV-positive and 34 HIV-negative MSM who enrolled into a prospective cohort in Bangkok, Thailand...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720441/increased-tnf-alpha-and-stnfr2-levels-are-associated-with-high-grade-anal-squamous-intraepithelial-lesions-in-hiv-positive-patients-with-low-cd4-level
#3
Takeshi Haga, Jimmy T Efird, Sharof Tugizov, Joel M Palefsky
Compared with HIV-negative individuals, HIV-positive individuals have a higher prevalence of anogenital human papillomavirus (HPV) infection, the causative agent of anogenital cancer. TNF-alpha is a major proinflammatory cytokine. sTNFR2 is the soluble form of one of its receptors and is strongly expressed on stimulated lymphocytes. To further understand the role of TNF-alpha, sTNFR2 and other cytokines in the pathogenesis in HPV-related neoplasia, the profiles of serum cytokines in high-risk patients were analyzed for association with anal lesion status...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28719486/p16-expression-and-biological-behavior-of-flat-vulvar-low-grade-squamous-intraepithelial-lesions-lsil
#4
Natasha Lewis, Luis Z Blanco, Kruti P Maniar
Flat low-grade squamous intraepithelial lesion (LSIL) of the vulva [vulvar intraepithelial neoplasia (VIN) 1, flat condyloma] is an uncommon entity with poorly understood biological behavior. We aimed to determine the risk of subsequent vulvar high-grade squamous intraepithelial lesion (HSIL) or carcinoma following a diagnosis of vulvar LSIL/VIN 1, as well as the frequency and predictive value of p16 immunohistochemical expression in this setting. Of the 51 included cases, p16 positivity (diffuse block staining) was identified in 2 (4%)...
November 30, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28705710/using-p16-immunohistochemistry-to-classify-morphologic-cervical-intraepithelial-neoplasia-2-correlation-of-ambiguous-staining-patterns-with-hpv-subtypes-and-clinical-outcome
#5
Yuxin Liu, Mahfood Alqatari, Kieran Sultan, Fei Ye, Dana Gao, Keith Sigel, David Zhang, Tamara Kalir
P16(INK4a) immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. While most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It is unclear whether ambiguous p16 immunoreactivity indicates oncogenic HPV infection or risk of progression. Herein, we compared HPV genotypes and subsequent High-grade Squamous Intraepithelial Lesion (HSIL) outcomes among 220 cervical biopsies with a differential diagnosis of Cervical Intraepithelial Neoplasia 2 (CIN 2) based on hematoxylin and eosin morphology and varying degrees of p16 immunoreactivity...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28695429/cryotherapy-for-intra-and-perianal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-men-who-have-sex-with-men
#6
Matthijs L Siegenbeek van Heukelom, Karien C M Gosens, Jan M Prins, Henry J C de Vries
BACKGROUND: Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders. METHODS: This retrospective, non-randomized study included HIV-positive MSM who received intra- and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015...
July 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28693176/flexible-magnifying-endoscopy-with-narrow-band-imaging-for-the-diagnosis-of-uterine-cervical-tumors-a-cooperative-study-among-gastrointestinal-endoscopists-and-gynecologists-to-explore-a-novel-microvascular-classification-system
#7
Noriko Nishiyama, Kenji Kanenishi, Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Taiga Chiyo, Nobuya Kobayashi, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Ayako Fujimori, Makoto Oryu, Chiaki Tenkumo, Megumi Ishibashi, Uiko Hanaoka, Toshiyuki Hata, Yumi Miyai, Kyuichi Kadota, Reiji Haba, Tsutomu Masaki
Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro-vessels, has excellent diagnostic potential for early gastrointestinal epithelial neoplasia. Conventional diagnostic tools for uterine cervical epithelial tumors are still unsatisfactory. An accurate diagnostic tool for uterine cervical epithelial tumors is required to preserve the reproductive ability of young women with uterine cervical tumors. Flexible NBI-ME was performed in patients with cervical squamous cell lesions that required further examinations based on their Pap smear results (cytology ≥ low-grade squamous intraepithelial lesion) at Kagawa University Hospital between April 2014 and April 2015...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692681/cervical-hpv-type-specific-pre-vaccination-prevalence-and-age-distribution-in-croatia
#8
Ivan Sabol, Nina Milutin Gašperov, Mihaela Matovina, Ksenija Božinović, Goran Grubišić, Ivan Fistonić, Dragan Belci, Laia Alemany, Sonja Džebro, Mara Dominis, Mario Šekerija, Sara Tous, Silvia de Sanjosé, Magdalena Grce
The main etiological factor of precancerous lesion and invasive cervical cancer are oncogenic human papillomaviruses types (HPVs). The objective of this study was to establish the distribution of the most common HPVs in different cervical lesions and cancer prior to the implementation of organized population-based cervical screening and HPV vaccination in Croatia. In this study, 4,432 cervical specimens, collected through a 16-year period, were tested for the presence of HPV-DNA by polymerase chain reaction (PCR) with three sets of broad-spectrum primers and type-specific primers for most common low-risk (LR) types (HPV-6, 11) and the most common high-risk (HR) types (HPV-16, 18, 31, 33, 45, 52, 58)...
2017: PloS One
https://www.readbyqxmd.com/read/28691644/distribution-and-attribution-of-high-risk-human-papillomavirus-genotypes-in-cervical-precancerous-lesions-in-china
#9
Wenpeng Wang, Jusheng An, Yan Song, Minjie Wang, Manni Huang, Lingying Wu
While human papillomavirus vaccine was recently approved by China Food and Drug Administration, mapping of high-risk human papillomavirus distribution and attribution in cervical precancerous lesions in China becomes critical in development of a high-risk human papillomavirus-based cervical cancer screening and prevention strategy. In total, 1016 patients with cervical precancerous lesions diagnosed in the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences were analyzed retrospectively, including 111 patients with low-grade squamous intraepithelial lesions and 905 patients with high-grade squamous intraepithelial lesions...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28688605/human-papillomavirus-prevalence-in-the-anus-and-urine-among-hiv-infected-japanese-men-who-have-sex-with-men
#10
Hiroshi Yaegashi, Kazuyoshi Shigehara, Ichiro Itoda, Mitsuaki Ohkodo, Kazufumi Nakashima, Shohei Kawaguchi, Mikio Ueda, Koji Izumi, Yoshifumi Kadono, Hiroko Ikeda, Mikio Namiki, Atsushi Mizokami
BACKGROUND: The present study investigated human papillomavirus (HPV) prevalence in anal and urine samples, and evaluated cytological findings among human immunodeficiency virus (HIV)-infected Japanese men who have sex with men (MSM). METHODS: A total of 148 patients were enrolled. Anal and urine samples were collected from each participant, and a HPV-DNA test and genotyping were performed using flow-through hybridization. In addition, anal cytology was evaluated based on Papanicolaou staining...
July 6, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28682436/colposcopic-patterns-of-vaginal-intraepithelial-neoplasia-a-focus-on-low-grade-lesions
#11
F Sopracordevole, N Clemente, M Barbero, A Agarossi, P Cattani, P Garutti, M G Fallani, A Pieralli, F Boselli, A Frega, G De Piero, A Del Fabro, M Buttignol, A Ciavattini
OBJECTIVE: The aim of this study was to evaluate the colposcopic patterns observed in women with a histopathological diagnosis of vaginal intraepithelial neoplasia, with a particular interest in analyzing the colposcopic characteristics of low-grade squamous intraepithelial lesions (LSIL). PATIENTS AND METHODS: Medical charts and colposcopy records of women diagnosed with vaginal intraepithelial neoplasia from January 1995 to December 2015, were analyzed in a multicenter retrospective case series...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28678394/risk-of-persistent-or-recurrent-cervical-neoplasia-in-patients-with-pure-adenocarcinoma-in-situ-ais-or-mixed-ais-and-high-grade-cervical-squamous-neoplasia-cervical-intraepithelial-neoplasia-grades-2-and-3-cin-2-3-a-population-based-study
#12
Elizabeth Codde, Aime Munro, Colin J R Stewart, Katrina Spilsbury, Shirley Bowen, Jim Codde, Nerida Steel, Yee Leung, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, Paul A Cohen
OBJECTIVE: To compare outcomes of patients with pure AIS and mixed AIS/CIN 2/3 lesions including the incidence of AIS persistence, recurrence and progression to adenocarcinoma. DESIGN: Retrospective cohort study. SETTING: Statewide population in Western Australia. POPULATION: Women diagnosed with AIS between 2001 and 2012. METHODS: We conducted a retrospective, population-based cohort study. MAIN OUTCOME MEASURES: De-identified linked data were utilized to ascertain the association between patient age at excisional treatment, margin status, lesion type, lesion size, and risk of persistent AIS (defined as the presence of AIS <12 months from treatment), recurrent AIS (≥12 months post treatment), and adenocarcinoma...
July 5, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28669173/flow-cytometric-analysis-of-dna-ploidy-in-liquid-based-cytology-for-cervical-pre-cancer-and-cancer
#13
Sridhar Mishra, Namrata P Awasthi, Nuzhat Husain, Akansha Anand, Yashodhara Pradeep, Roohi Ansari, Sarita Saxena
Background: DNA ploidy analysis of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer samples by flow cytometry (FCM) has been established as an aid to prognostic assessment. Liquid based cytology (LBC) increases diagnostic specificity by using ancillary techniques that provide information beyond morphology. The present study was undertaken to assess DNA ploidy in LBC samples as an adjunct for early detection of cervical pre-cancer and cancer. Methods: DNA ploidy assessment was performed on LBC samples of 50 cases and 31 controls...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28666641/high-grade-squamous-intraepithelial-lesion-hsil-of-the-cervix-with-bizarre-cytological-appearances-pleomorphic-hsil-a-review-of-19-cases
#14
Colin J R Stewart
Cervical high-grade squamous intraepithelial lesions (HSILs) are typically characterised by a proliferation of immature basaloid cells with relatively uniform hyperchromatic nuclei. In this report we describe 19 cases of HSIL exhibiting focal but very marked nuclear atypia often associated with multinucleation ('pleomorphic HSIL'). The bizarre cytological changes mainly involved the basal epithelium particularly in endocervical crypts where the neoplastic cells undermined the native glandular epithelial cells...
June 27, 2017: Pathology
https://www.readbyqxmd.com/read/28657397/histological-outcomes-in-conventional-cervical-cytology-for-invasive-carcinoma-not-always-cancer
#15
Flávia Regina Peixoto Pereira, Leila Cristina Soares, Marco Aurélio Pinho de Oliveira
The value of cytology for the detection of invasive cancer remains unknown. We performed a retrospective cohort study with 884 patients diagnosed of premalignant lesions and invasive carcinoma in cytology. 382 (43.2%) of them had cytological results of high-grade squamous intraepithelial lesions (HSIL), 244 (27.6%) showed low-grade squamous intraepithelial lesions (LSIL), 120 (13.6%) patients had atypical squamous cells of undetermined significance (ASC-US), 67 (7.6%) patients with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H), 38 (4...
June 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28655061/outcomes-in-women-with-cytology-showing-atypical-squamous-cells-of-undetermined-significance-with-vs-without-human-papillomavirus-testing
#16
Jack Cuzick, Orrin Myers, Ji-Hyun Lee, Yang Shi, Julia C Gage, William C Hunt, Michael Robertson, Cosette M Wheeler
Importance: Little is known about the long-term yield of high-grade cervical intraepithelial neoplasia (CIN) and the influence on biopsy and treatment rates of human papillomavirus (HPV) triage of cytology showing atypical squamous cells of undetermined significance (hereafter ASC-US cytology). Objective: To examine 5-year outcomes after ASC-US cytology with vs without HPV testing. Design, Setting, and Participants: In this observational study, all cervical cytology and HPV testing reports from January 1, 2007, to December 31, 2012, were obtained for women throughout New Mexico and linked to pathology reports...
June 22, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28643492/human-papillomavirus-genotype-distribution-among-18-815-women-in-13-korean-cities-and-relationship-with-cervical-cytology-findings
#17
Eun Hee Nah, Seon Cho, Suyoung Kim, Han Ik Cho
BACKGROUND: The prevalence and genotype distribution of Human papillomavirus (HPV) infection vary depending on geographical region and the immunity provided by vaccines. This study aimed to clarify the recent prevalence and genotype distribution of HPV according to age and cervical cytology findings in Korea. METHODS: This study included 18,815 health examinees that underwent cervical cytology and HPV genotyping tests at 16 centers of Korean Association of Health Promotion in 13 cities in Korea, between January 2014 and October 2015...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28638271/proex-c-as-diagnostic-marker-for-detection-of-urothelial-carcinoma-in-urinary-samples-a-review
#18
REVIEW
Gerardo Botti, Maria Gabriella Malzone, Elvira La Mantia, Micaela Montanari, Daniela Vanacore, Sabrina Rossetti, Vincenzo Quagliariello, Carla Cavaliere, Rossella Di Franco, Luigi Castaldo, Gianluca Ametrano, Francesca Cappuccio, Francesco Jacopo Romano, Raffaele Piscitelli, Maria Filomena Pepe, Carmine D'Aniello, Gaetano Facchini
The gold standard for the detection of urothelial carcinoma is represented by urethro-cystoscopy and biopsy. Both procedures are invasive and expensive and therefore cytology is often used as first approach to investigate on a possible neoplasia, being a safe and cost-effective diagnostic modality of evaluation. Because cytology alone is not highly sensitive for detection of low grade urothelial carcinoma and recurrence of the disease, several adjunct markers and urine based tests for urothelial carcinoma have been developed, which can help in the final diagnosis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28626767/closer-to-a-uniform-language-in-colposcopy-study-on-the-potential-application-of-2011-international-federation-for-cervical-pathology-and-colposcopy-terminology-in-clinical-practice
#19
Yanyun Li, Xiaoling Duan, Long Sui, Fengying Xu, Shuifang Xu, Hongwei Zhang, Congjian Xu
As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28614204/human-papillomavirus-hpv-genotypes-in-condylomas-intraepithelial-neoplasia-and-invasive-carcinoma-of-the-penis-using-laser-capture-microdissection-lcm-pcr-a-study-of-191-lesions-in-43-patients
#20
María J Fernández-Nestosa, Nuria Guimerà, Diego F Sanchez, Sofía Cañete-Portillo, Elsa F Velazquez, David Jenkins, Wim Quint, Antonio L Cubilla
Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR...
June 13, 2017: American Journal of Surgical Pathology
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