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high grade squamous intraepithelial lesion

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https://www.readbyqxmd.com/read/28182079/immunocytoexpression-profile-of-proexc-in-smears-interpreted-as-asc-us-asc-h-and-cervical-intraepithelial-lesion
#1
Zeynep Tosuner, İlknur Türkmen, Sema Arici, Cavide Sönmez, Seval Turna, Öykü Onaran
AIMS: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. SETTINGS AND DESIGN: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28181989/-influence-of-age-in-the-prevalence-of-high-risk-human-papiloma-virus-in-women-with-pre-neoplasic-cervical-lesions-in-navarra-spain
#2
María Rosario Mercado Gutiérrez, Carolina Arean Cuns, María Luisa Gómez Dorronsoro, Irene Paniello Alastruey, Fermin Mallor Giménez, Maria Dolores Lozano Escario, Mercedes Santamaría Martínez
OBJECTIVE: Cervical carcinoma (CC) is the second cause of death among women aged 15 and 44 in Spain. CC is linked to hig-risk human papillomavirus (HR-HPV) infection and its prevalence varies according age and geographical region. The awereness of the latter is essential for public health prevention efforts. The aim was to study the age related in HR-HPV genotypes in cytologies with squamous intraepithelial lesion (SIL). METHODS: From a total of 67,935 ginecologic cytologies over a four-year period, we selected cytologic specimens with SIL...
9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28160449/the-significance-of-parakeratosis-alone-in-cervicovaginal-cytology-of-turkish-women
#3
Gozde Kir, Billur Cosan Sarbay, Hatice Seneldir
BACKGROUND: We aimed to analyze the significance of parakeratosis on an otherwise negative Papanicalaou (Pap) smear, in the absence of any characteristic human papilloma virus (HPV) findings. METHODS: A total of 22,076 Papanicalaou smears that were diagnosed as negative for intraepithelial lesions or malignancy between 2013 and 2015 were included in this study. Samples were separated into two groups, according to the presence of parakeratosis. We investigated the association between parakeratosis in the cytology results and a high-risk HPV status and high-grade squamous intraepithelial lesion (HSIL) in the colposcopic biopsy specimens...
February 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28150409/bizarre-cell-dysplasia-of-the-cervix
#4
Ondrej Ondič, Radoslav Ferko, Jana Kašpírková, Marián Švajdler, Boris Rýchly, Peter Talarčík, Jiří Bouda, Michal Michal
AIM: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD). METHODS: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28143439/human-papillomavirus-infections-among-women-with-cervical-lesions-and-cervical-cancer-in-eastern-china-genotype-specific-prevalence-and-attribution
#5
Lei Zhang, Qingqing Bi, Hua Deng, Jing Xu, Juan Chen, Meilian Zhang, Xiaofeng Mu
BACKGROUND: Cervical cancer and its precursor, high-grade cervical intraepithelial neoplasia (CIN2/3), are associated with persistent high-risk human papillomavirus (HPV) infection. HPV genotype prevalence varies with severity of cervical lesions, patient age and geographical location. The aim of this study was to investigate HPV genotypes prevalence and attribution according to the severity of cervical lesions among Chinese women. METHOD: A 4-year surveillance study was performed...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28141783/prevalence-of-anal-hpv-and-anal-dysplasia-in-hiv-infected-women-from-johannesburg-south-africa
#6
Bridgette J Goeieman, Cynthia S Firnhaber, Eefje Jong, Pam Michelow, Avril Swarts, Anna-Lise Williamson, Bruce Allan, Jennifer S Smith, Patricia Kegorilwe, Timothy J Wilkin
BACKGROUND: Anal cancer is a relatively common cancer among HIV-infected populations. There are limited data on the prevalence of anal high-risk human papillomavirus (HR-HPV) infection and anal dysplasia in HIV-infected women from resource-constrained settings. METHODS: A cross-sectional study of HIV-infected women age 25-65 recruited from an HIV clinic in Johannesburg, South Africa. Cervical and anal swabs were taken for conventional cytology and HR-HPV testing...
January 30, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28138337/human-papillomavirus-genotypes-associated-with-cervical-precancerous-lesions-and-cancer-in-the-highest-area-of-cervical-cancer-mortality-longnan-china
#7
Jin Zhao, Zhong Guo, Qiang Wang, Tianbin Si, Shuyan Pei, Chenjing Wang, Hongmei Qu, Jianbin Zhong, Ying Ma, Cong Nie, Dan Zhang
BACKGROUND: The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China. METHODS: Between 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes. RESULTS: Compared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28127819/comparing-papanicolaou-test-results-obtained-during-pregnancy-and-post-partum
#8
Kazuhiro Suzuki, Madoka Furuhashi, Takuya Kawamura, Michiko Kubo, Kazuhiro Osato, Takaharu Yamawaki
AIM: Cervical cancer onset initially occurs during youth. Papanicolaou tests performed in early pregnancy can detect cervical cancer; however, Papanicolaou tests during pregnancy have been noted to be inaccurate, reflecting changes associated with pregnancy. Therefore, we assessed the effect of pregnancy on Papanicolaou test results. METHODS: Of 1351 pregnant women who delivered at Ise Red Cross Hospital between January 2010 and December 2014, 1213 underwent Papanicolaou tests at early pregnancy and post-partum...
January 27, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28121939/multiple-preinvasive-and-invasive-hpv-related-lesions-of-the-anogenital-tract-in-a-female-patient-with-hiv-infection-a-case-report
#9
Nicolò Clemente, Lara Alessandrini, Emanuela Vaccher, Antonino De Paoli, Monica Buttignol, Vincenzo Canzonieri, Francesco Sopracordevole
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28118377/%C3%AE-h2ax-expression-as-a-potential-biomarker-differentiating-between-low-and-high-grade-cervical-squamous-intraepithelial-lesions-sil-and-high-risk-hpv-related-sil
#10
Konstantinos Leventakos, Sotirios Tsiodras, Theodore Kelesidis, Maria Kefala, Christine Kottaridi, Aris Spathis, Alina-Roxani Gouloumi, Abraham Pouliakis, Asimakis Pappas, Vasileios Sioulas, Charalambos Chrelias, Petros Karakitsos, Ioannis Panayiotides
BACKGROUND: γH2AX is a protein biomarker for double-stranded DNA breakage; its expression was studied in cervical squamous intraepithelial lesions and carcinomas. METHODS: Immunostaining for phospho-γH2AX was performed in sections from histologically confirmed cervical SIL and carcinomas, as well as from normal cervices used as controls. In total, 275 cases were included in the study: 112 low grade SIL (LGSIL), 99 high grade SIL (HGSIL), 24 squamous cell carcinoma (SCC), 12 adenocarcinoma and 28 cervical specimens with no essential lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28115985/human-papillomavirus-infection-in-anal-intraepithelial-lesions-from-hiv-infected-cuban-men
#11
Celia M Limia, Yudira Soto, Yanara García, Orestes Blanco, Vivian Kourí, María V López, María E Toledo, Lissette Pérez, Yoanna Baños, Yaniris Caturla, Francisco Aguayo
BACKGROUND: An association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, anal cancer is one of the most common non-AIDS-defining malignancies. METHODS: A cross-sectional study to detect anal lesions and HPV infection was performed. Anal mucosa samples were collected from 56 HIV-infected men from Cuba. The cytological diagnosis was done according to Bethesda 2001 System...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28098569/human-papillomavirus-genotyping-of-incidental-malignant-and-premalignant-lesions-on-hemorrhoidectomy-specimens
#12
Yiang Hui, M Ruhul Quddus, Jayasimha N Murthy, Dongfang Yang, C James Sung, Shaolei Lu, Murray B Resnick, Li Juan Wang
Routine histopathologic examination of hemorrhoidectomy specimens is controversial having been described as not useful and expensive with few of these common cases demonstrating incidental lesions. However, unexpected premalignant and malignant lesions have been detected on excised hemorrhoids. The high-risk human papillomavirus (HR-HPV) types associated with these incidentally identified high-grade lesions are presently unknown. We aimed to identify cases of incidental high-grade anal intraepithelial neoplasia (HG-AIN) and anal squamous cell carcinoma incidentally discovered on hemorrhoidectomy specimens, genotype HR-HPVs from these lesions, and assess p53 and p16 expression by immunohistochemistry to identify risk factors for their development...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28091842/squamous-cell-dysplasia-in-the-proximal-rectum-of-three-patients-treated-for-ulcerative-colitis-on-immunomodulators
#13
James G Connolly, Stephen E Goldstone
BACKGROUND: Anal canal high-grade squamous intraepithelial lesion (HSIL) is the precursor to anal cancer. Immunocompromised patients are at increased risk and disease is usually within 3 cm from the anal verge. High-resolution anoscopy (HRA) with an 8-cm anoscope is used to identify and guide cautery treatment of HSIL. PURPOSE: We report three patients with a long-term history of ulcerative colitis (UC) treated with systemic immunomodulators who developed proximally located rectal HSIL...
January 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28091444/impact-of-visual-inspection-with-acetic-acid-plus-cryotherapy-see-and-treat-approach-on-the-reduction-of-the-population-burden-of-cervical-preinvasive-lesions-in-southeast-nigeria
#14
C O Chigbu, A K Onyebuchi, E F Nnakenyi, C C Egbuji
OBJECTIVE: The aim of this study is to determine the impact of visual inspection with acetic acid (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical squamous intraepithelial lesion (SIL). METHODS: Women in four rural communities in Southeast Nigeria were screened with VIA. Women who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28060368/squamous-cell-carcinoma-of-the-upper-aerodigestive-tract-dysplasia-and-select-variants
#15
Bruce M Wenig
Upper aerodigestive tract (UADT) mucosal premalignant lesions include non-keratinizing and keratinizing intraepithelial dysplasia. The keratinizing type of intraepithelial dysplasia represents the majority of UADT dysplasias. Historically, grading of UADT dysplasias has followed a three tier system to include mild, moderate and severe dysplasia. Recent recommendations have introduced a two tier grading scheme to including low-grade (ie, mild dysplasia) and high-grade (moderate and severe dysplasia/carcinoma in situ) providing for better consensus among pathologists in the interpretation of such dysplastic lesions...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28052328/type-dependent-association-between-risk-of-cervical-intraepithelial-neoplasia-and-viral-load-of-oncogenic-human-papillomavirus-types-other-than-types-16-and-18
#16
Long Fu Xi, Mark Schiffman, Yang Ke, James P Hughes, Denise A Galloway, Zhonghu He, Ayaka Hulbert, Rachel L Winer, Laura A Koutsky, Nancy B Kiviat
Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) triage study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals. Viral load measurements were performed on the first type-specific HPV-positive specimens...
January 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28051906/clinicopathological-significance-of-survivin-expression-in-patients-with-cervical-cancer-a-systematic-meta-analysis
#17
Yibing Fan, Juan Chen
BACKGROUND: Survivin has been shown to play an important role in cancer pathogenesis. However, its role in cervical cancer development is still controversial. This study was performed to evaluate the clinical significance of survivin expression in cervical cancer. METHODS: Search of some online electronic databases was conducted to identify available studies. The pooled odds ratios (ORs) with its 95% confidence intervals (CIs) were calculated and analyzed. RESULTS: Finally, 18 eligible studies with 791 cervical cancer patients, 1,013 cervical intraepithelial neoplasia (CIN) lesions, 199 normal cervical tissues, and 95 samples with chronic cervicitis were identified in this analysis...
January 4, 2017: Bioengineered
https://www.readbyqxmd.com/read/28040505/dlg1-polarity-protein-expression-associates-with-the-disease-progress-of-low-grade-cervical-intraepithelial-lesions
#18
Ana Laura Cavatorta, Alejandra Di Gregorio, Marina Bugnon Valdano, Federico Marziali, Mariela Cabral, Hebe Bottai, Jorge Cittadini, Ana Lia Nocito, Daniela Gardiol
Human Discs large tumour suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In this work, we evaluated the expression of DLG1 and its contribution to the progress of cervical lesions in order to investigate a potential role of this polarity protein in human oncogenic processes. We analyzed cervical biopsies from women with low-grade squamous intraepithelial lesion (LSIL) diagnosis (n=30), for DLG1 expression by immunohistochemistry...
December 29, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28029192/factors-related-to-inter-observer-reproducibility-of-conventional-pap-smear-cytology-a-multilevel-analysis-of-smear-and-laboratory-characteristics
#19
A Baena, E Guevara, M Almonte, J Arias-Stella, P Sasieni, G I Sanchez
OBJECTIVE: To identify factors that influence the inter-observer reproducibility of the routine, conventional Pap smear cytology (Pap smear test) in a network of certificated laboratories in a middle-income Latin American country. METHODS: Twenty-six laboratories provided each an average of 26 negative for malignancy (NILM) and high-grade squamous intraepithelial lesion (HSIL) Pap smears. An external panel reviewed the slides. The kappa index and multilevel logistic regression were used to estimate the reproducibility and odds ratios (OR) of a false result with 95% confidence intervals (95% CI), respectively...
December 28, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28026078/screening-for-cervical-carcinoma-in-hiv-infected-women-analysis-of-main-risk-factors-for-cervical-cytologic-abnormalities
#20
Matilde Sansone, Gabriele Saccone, Annalisa Migliucci, Rosa Saviano, Angela Capone, Giuseppe Maria Maruotti, Dario Bruzzese, Pasquale Martinelli
AIM: The aim of this study was to identify potential predictive factors for cervical disease in women with HIV and to evaluate adherence during follow-up to cervical cancer screening. METHODS: In order to identify the independent role of factors associated with the presence of a cervical abnormality, all of the variables showing in univariate analyses a potential association with the outcome variable (presence of cervical abnormalities) were entered into a multivariate logistic regression model, along with age at first visit to our center, and age at diagnosis...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
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