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Endocrinology & Diabetes

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https://www.readbyqxmd.com/read/29649995/the-prevalence-and-systemic-risk-factors-of-diabetic-macular-edema-a-cross-sectional-study-from-turkey
#1
Durgul Acan, Mehmet Calan, Duygu Er, Tugba Arkan, Nilufer Kocak, Firat Bayraktar, Suleyman Kaynak
BACKGROUND: The aim of this study was to evaluate the prevalence of diabetic macular edema (DME) utilizing optical coherence tomography (OCT), and to clarify the effects of the systemic findings and risk factors on the development of DME. METHODS: This cross-sectional study was conducted in the departments of ophthalmology and endocrinology at the Dokuz Eylul University School of Medicine in Izmir, Turkey. The demographics, type and duration of diabetes mellitus, treatment modality, smoking and alcohol consumption habits, as well as the systemic blood pressure, renal functional tests, hemoglobulin A1c level, serum lipid profile, and 24-h urine albumin level were noted and statistically analyzed...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29649538/identification-of-factors-to-increase-efficacy-of-telemedicine-screening-for-diabetic-retinopathy-in-endocrinology-practices-using-the-intelligent-retinal-imaging-system-iris-platform
#2
Sapna Naik, Charles C Wykoff, William C Ou, Jonathan Stevenson, Sunil Gupta, Ankoor R Shah
AIMS: Diabetic retinopathy (DR) and diabetic macular edema (DME) can be evaluated using telemedicine systems, such as the Intelligent Retinal Imaging Systems (IRIS), in patients with Diabetes Mellitus (DM). In an endocrinology-based population utilizing IRIS we determine prevalence rates of DR and DME, and identify associated epidemiologic correlations. METHODS: This is a multicenter, retrospective chart review using screening data from IRIS. Centers for Disease Control and Prevention (CDC) data on epidemiologic variables (by county) namely, prevalence of DM, incidence of DM, obesity, and time of physical inactivity, were compared against prevalence rates of DR found at screening...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29643899/influence-of-apelin-13-on-osteoporosis-in-type-2-diabetes-mellitus-a-clinical-study
#3
Supin Liu, Wenlong Wang, Linlin Yin, Yitang Zhu
Objective: To investigate the relationship between serum level of Apelin-13 and bone mineral density (BMD) as well as other parameters, and determine the influence of Apelin-13 on osteoporosis in patients with Type-2 diabetes mellitus. Methods: Seventy-six patients with Type-2 diabetes mellitus were recruited from Department of Endocrinology of our hospital between January 2013 and July2017. The clinical data, including age, gender, height, weight, body mass index (BMI) and disease duration were recorded for all patients...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643875/association-of-clinical-and-laboratory-parameters-with-ambulatory-arterial-stiffness-index-in-acromegaly-patients
#4
Faruk Kilinc, Zafer Pekkolay, Fatih Demircan, Nevzat Gozel, Alpaslan Kemal Tuzcu
Objective: In this study, we determined the relationship between the ambulatory arterial stiffness index (AASI) and clinical and laboratory parameters in patients with acromegaly. Methods: Sixty-five patients with acromegaly, who visited to Dicle University Medical Faculty Department of Endocrinology (33 females and 32 males), were included in this study. The study control group consisted of 65 subjects. Demographic and clinical data were recorded. Laboratory data (complete blood count, blood urea nitrogen, creatinine, electrolytes, albumin, lipid profile, growth hormone [GH], insulin-like growth factor-1, and the 75-g oral glucose tolerance test) performed over the last year were evaluated...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29615169/serum-cystatin-c-as-an-early-diagnostic-biomarker-of-diabetic-kidney-disease-in-type-2-diabetic-patients
#5
Ayesha Qamar, Asma Hayat, Tariq Mahmood Ahmad, Alamgir Khan, Mohammad Najam Ul Hasnat, Sufyan Tahir
OBJECTIVE: To determine the diagnostic accuracy and cut-off values of serum cystatin C as early diagnostic biomarker of diabetic kidney disease. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Department of Pathology, Army Medical College, Rawalpindi in collaboration with Endocrinology Department, Military Hospital (MH), Rawalpindi from November 2015 to November 2016. METHODOLOGY: One hundred and nineteen diagnosed patients of type 2 diabetes mellitus were enrolled in the study from the outpatient Endocrinology Department of the MH Rawalpindi...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29601949/association-study-of-srebf-2-gene-polymorphisms-and-the-risk-of-type-2-diabetes-in-a-sample-of-iranian-population
#6
Hamidreza Galavi, Nafiseh Noorzehi, Ramin Saravani, Saman Sargazi, Fatemeh Mollashahee-Kohkan, Hojat Shahraki
Type 2 diabetes mellitus (T2D) as an important metabolic disorder is accompanied by dysregulation in lipid metabolism. Sterol regulatory element-binding factor-2 (SREBF-2) gene has a substantive role in lipid metabolism. Recently published report indicated the overexpression of this gene in diabetic patients. So, in this preliminary study we evaluated the effects of three common single nucleotide polymorphisms (SNPs), rs1052717G/A, rs2267439C/T, and rs2267443G/A in risk of T2D in a sample of Iranian population...
March 27, 2018: Gene
https://www.readbyqxmd.com/read/29581804/anxiety-and-depression-among-adult-patients-with-diabetic-foot-prevalence-and-associated-factors
#7
Ali Ahmad, Mousa Abujbara, Hashem Jaddou, Nidal A Younes, Kamel Ajlouni
Background: Diabetic foot is a frequent complication of diabetes mellitus with subsequent disturbances in the daily life of the patients. The co-existence of depression and anxiety among diabetic foot patients is a common phenomenon and the role of each of them in perpetuating the other is highlighted in the literature. Our study aimed to determine the prevalence rates of anxiety and depression, and to examine the associated risk factors among diabetic foot patients. Methods: This is a cross-sectional study...
May 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29579509/a-comparison-of-aggression-and-self-injury-among-type-1-diabetic-and-healthy-adolescents-a-sample-from-turkey
#8
Yagmur Sezer Efe, Emine Erdem
BACKGROUND: Adolescents tend to have risky behaviors like aggression and self-injury due to the age period characteristics. The risk of aggression and self-injury may increase in adolescents with the addition of chronic diseases. OBJECTIVES: This study was conducted descriptively to determine and compare the aggression and self-injury in those with type 1 diabetes mellitus (T1DM) and healthy counterparts. METHODS: The study sample consisted of 60 adolescents with T1DM followed up in the child endocrinology polyclinic of a university hospital and 319 healthy counterparts, 15-18 aged, at 9th-12th grade at high school...
April 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29577540/burden-of-cardio-renal-metabolic-conditions-in-adults-with-type-2-diabetes-within-the-diabetes-collaborative-registry
#9
Suzanne V Arnold, Mikhail Kosiborod, Jingyan Wang, Peter Fenici, Goran Gannedahl, Robert J LoCasale
We examined the prevalence of cardio-renal-metabolic (CaReMe) conditions and their combinations among 530,747 adults with type 2 diabetes in a US-based outpatient registry of 271 primary care, cardiology, and endocrinology offices. We evaluated the following CaReMe conditions: hypertension, hyperlipidemia, coronary artery disease (CAD), chronic kidney disease (CKD), cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and gout or hyperuricemia; prevalence estimates were adjusted based on the distribution of diabetes by age in the 2015 US population...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29571505/screening-thresholds-one-size-does-not-fit-all
#10
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
April 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29563068/pediatric-endocrine-and-metabolic-diseases-and-proteomics
#11
Ioanna Kosteria, Christina Kanaka-Gantenbein, Athanasios K Anagnostopoulos, George P Chrousos, George Th Tsangaris
The principles of Predictive, Preventive and Personalized Medicine (PPPM) dictate the need to recognize individual susceptibility to disease in a timely fashion and to offer targeted preventive interventions and treatments. Proteomics is a state-of-the art technology- driven science aiming at expanding our understanding of the pathophysiologic mechanisms that underlie disease, but also at identifying accurate predictive, diagnostic and therapeutic biomarkers, that will eventually promote the implementation of PPPM...
March 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29547046/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-2018-position-statement-on-integration-of-insulin-pumps-and-continuous-glucose-monitoring-in-patients-with-diabetes-mellitus
#12
George Grunberger, Yehuda Handelsman, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, Richard A Haas, Victor L Roberts, Guillermo E Umpierrez
This document represents the official position of the American Association of Clinical Endocrinologists and American College of Endocrinology. Where there are no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. Every effort was made to achieve consensus among the committee members. Position statements are meant to provide guidance, but they are not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician...
March 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29535947/prevalence-of-charcot-arthropathy-in-type-2-diabetes-patients-aged-over-50-years-with-severe-peripheral-neuropathy-a-retrospective-study-in-a-tertiary-care-south-indian-hospital
#13
Dharmadas Salini, Kumar Harish, Pillay Minnie, Karimassery R Sundaram, Bal Arun, Chirukandath J Sandya, Thacho S Mangalanandan, Lakshmanan Vivek, Valiyaparambil P Praveen
Aims: Available literature on the prevalence of Charcot arthropathy (CA) represents mainly Western population. No study has been reported from India so far. Hence we attempted to study the prevalence of CA in patients with type 2 diabetes mellitus and severe peripheral neuropathy (T2DMPN), belonging to Indian population amongst whom type 2 diabetes is on the rise in alarming proportions. Materials and Methods: Medical records of 3387 patients who performed an objective vibration perception threshold test during the year 2015 were screened for T2DMPN...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29531299/feasibility-and-patient-acceptability-of-a-novel-artificial-intelligence-based-screening-model-for-diabetic-retinopathy-at-endocrinology-outpatient-services-a-pilot-study
#14
Stuart Keel, Pei Ying Lee, Jane Scheetz, Zhixi Li, Mark A Kotowicz, Richard J MacIsaac, Mingguang He
The purpose of this study is to evaluate the feasibility and patient acceptability of a novel artificial intelligence (AI)-based diabetic retinopathy (DR) screening model within endocrinology outpatient settings. Adults with diabetes were recruited from two urban endocrinology outpatient clinics and single-field, non-mydriatic fundus photographs were taken and graded for referable DR ( ≥ pre-proliferative DR). Each participant underwent; (1) automated screening model; where a deep learning algorithm (DLA) provided real-time reporting of results; and (2) manual model where retinal images were transferred to a retinal grading centre and manual grading outcomes were distributed to the patient within 2 weeks of assessment...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29527307/compliance-with-guidelines-for-disease-management-in-diabetes-results-from-the-swissdiab-registry
#15
Katrin E Schimke, Frida Renström, Sandro Meier, Christoph Stettler, Michael Brändle
Objective: Tight glycemic control and aggressive treatment of additional cardiovascular risk factors can substantially reduce risk of diabetes-related complications. In 2013, the Swiss Society of Endocrinology and Diabetology (SSED) established national criteria on good disease management in diabetes, but little is known about compliance in clinical care. Here we assessed to what extent patients from two tertiary care centers in the German-speaking part of Switzerland enrolled in the Swiss Diabetes (SwissDiab) Registry adhere to the SSED criteria...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29518865/-clinical-characteristics-of-central-diabetes-insipidus-a-retrospective-analysis-of-230-cases
#16
J P Zhang, Q H Guo, Y M Mu, Z H Lyu, W J Gu, G Q Yang, J Du, J M Ba, J M Lu
Objective: To evaluate the clinical characteristics and etiologies of central diabetes insipidus (CDI). Methods: The clinical data of 230 patients with CDI in the Department of Endocrinology of Chinese PLA General Hospital from 2008 June to 2014 December were collected and analyzed retrospectively. Results: The three most common causes of CDI were idiopathic CDI, lymphocytic hypophysitis and intracranial germ cell tumors. Among all the CDI, the idiopathic CDI accounted for 37.48%. There were significant differences in age onset and gender distribution among the different causes of CDI...
March 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29518492/lower-mortality-and-cardiovascular-event-rates-in-patients-with-latent-autoimmune-diabetes-in-adults-lada-as-compared-with-type-2-diabetes-and-insulin-deficient-diabetes-a-cohort-study-of-4-368-patients
#17
Mette Wod, Reimar W Thomsen, Lars Pedersen, Knud B Yderstraede, Henning Beck-Nielsen, Kurt Højlund
BACKGROUND: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). METHODS: We conducted a cohort study of 4,368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012...
March 5, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29507945/hemoglobin-a1c-targets-for-glycemic-control-with-pharmacologic-therapy-for-nonpregnant-adults-with-type-2-diabetes-mellitus-a-guidance-statement-update-from-the-american-college-of-physicians
#18
Amir Qaseem, Timothy J Wilt, Devan Kansagara, Carrie Horwitch, Michael J Barry, Mary Ann Forciea
Description: The American College of Physicians developed this guidance statement to guide clinicians in selecting targets for pharmacologic treatment of type 2 diabetes. Methods: The National Guideline Clearinghouse and the Guidelines International Network library were searched (May 2017) for national guidelines, published in English, that addressed hemoglobin A1c (HbA1c) targets for treating type 2 diabetes in nonpregnant outpatient adults. The authors identified guidelines from the National Institute for Health and Care Excellence and the Institute for Clinical Systems Improvement...
March 6, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29494890/outcome-of-diabetes-insipidus-in-patients-with-rathke-s-cleft-cysts
#19
Masahiro Oishi, Yasuhiko Hayashi, Yasuo Sasagawa, Daisuke Kita, Osamu Tachibana, Mitsutoshi Nakada
OBJECTIVES: It is well-known that Rathke's cleft cysts (RCCs) infrequently cause headache, endocrinological dysfunction, and visual disturbance, and in rare cases, cause diabetes insipidus (DI). Although surgical evacuation of the cyst content can result in high rates of symptomatic improvement, not only the treatment efficacy but also the pathophysiology of DI with RCC are undetermined. The aim of this study is to elucidate the underlying mechanisms and outcomes of DI associated with RCCs...
February 21, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29492090/a-study-on-catalase-gene-promoter-polymorphism-21-a-t-rs7943316-in-healthy-pakistani-population
#20
Syeda Nuzhat Nawab, Sitwat Zehra, Asher Fawwad, Abid Azhar
Background & Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2 O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT-21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was designed to investigate the prevalence of mutant T allele frequency in healthy individuals...
November 2017: Pakistan Journal of Medical Sciences Quarterly
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