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Endocrinology & Diabetes

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https://www.readbyqxmd.com/read/29450857/hypokalemia-associated-with-pseudo-cushing-s-syndrome-and-magnesium-deficiency-induced-by-chronic-alcohol-abuse
#1
Masafumi Kurajoh, Keiko Ohsugi, Miki Kakutani-Hatayama, Takuhito Shoji, Hidenori Koyama
Hypokalemia and hypomagnesemia are frequently observed in patients with chronic alcoholism. However, the involvement of deranged cortisol regulation in patients with those conditions has not been reported. A 63-year-old Japanese male with chronic alcoholism was referred to the Department of Diabetes, Endocrinology and Metabolism for examination and treatment of hypokalemic periodic paralysis. Laboratory findings showed hypokalemia (2.3 mmol/l), as well as a high level of urinary excretion of potassium and hypomagnesemia (1...
February 15, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29440374/mechanisms-in-endocrinology-diabetic-cardiomyopathy-pathophysiology-and-potential-metabolic-interventions
#2
Eylem Levelt, Gaurav S Gulsin, Stefan Neubauer, Gerry P McCann
Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies, and cardiovascular outcomes with new classes of glucose lowering therapies...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#3
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29430158/delayed-presentation-of-turner-syndrome-challenge-to-optimal-management
#4
Uma Kaimal Saikia, Dipti Sarma, Yogesh Yadav
Background: Turner syndrome (TS) is a chromosomal disorder associated with dysmorphic features and comorbidities, with recent trends focusing on early diagnosis for adequate management. Aim: The aim is to study the age and mode of presentation of TS, associated comorbidities and look for any correlation with the genotype. Material and Methods: This was a retrospective analysis of girls with TS attending the endocrinology clinic of a tertiary care center...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29428407/subclinical-haemorrhage-in-non-functional-adenomas
#5
H Cebula, E Fasciglione, M D N Santin, J Todeschi, F Severac, F Proust, J-L Dietemann, B Goichot
AIM: The prevalence and risk factors of subclinical haemorrhage on non-functional adenomas (NFA) remain controversial. The primary aim of our study was to assess the incidence of subclinical haemorrhage (SH) and the secondary objectives were to evaluate the risk factors of SH and the impact of SH on pituitary function at diagnosis. PATIENTS AND METHODS: This retrospective transversal analysis included 95 patients between January 2012 and December 2014. The patients included in this series were all adults (>18 years of age), who presented a non-functional adenoma confirmed by an endocrinological evaluation and on dedicated MRI pituitary imaging...
February 7, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29413162/tackling-childhood-obesity-a-step-in-the-right-direction
#6
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
February 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29412814/peptide-degradation-and-the-role-of-dpp-4-inhibitors-in-the-treatment-of-type-2-diabetes
#7
Carolyn F Deacon
Dipeptidyl peptidase-4 (DPP-4) inhibitors are now a widely used, safe and efficacious class of antidiabetic drugs, which were developed prospectively using a rational drug design approach based on a thorough understanding of the endocrinology and degradation of glucagon-like peptide-1 (GLP-1). GLP-1 is an intestinal hormone with potent insulinotropic and glucagonostatic effects and can normalise blood glucose levels in patients with type 2 diabetes, but the native peptide is not therapeutically useful because of its inherent metabolic instability...
February 2018: Peptides
https://www.readbyqxmd.com/read/29398571/turning-the-waiting-room-into-a-classroom-weekly-classes-using-a-vegan-or-a-portion-controlled-eating-plan-improve-diabetes-control-in-a-randomized-translational-study
#8
Neal D Barnard, Susan M Levin, Lise Gloede, Rosendo Flores
BACKGROUND: In research settings, plant-based (vegan) eating plans improve diabetes management, typically reducing weight, glycemia, and low-density lipoprotein (LDL) cholesterol concentrations to a greater extent than has been shown with portion-controlled eating plans. OBJECTIVE: The study aimed to test whether similar benefits could be found using weekly nutrition classes in a typical endocrinology practice, hypothesizing that a vegan eating plan would improve glycemic control, weight, lipid concentrations, blood pressure, and renal function and would do so more effectively than a portion-controlled eating plan...
February 1, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29394455/retinol-binding-protein-4-is-positively-associated-with-bone-mineral-density-in-osteopenia-and-osteoporosis-type-2-diabetic-patients
#9
Jin Zhou, Nana Huang, Yu Cheng, Liang Li, Wenzhou Jiang, Wei Wang, Daping Wang, Yuxiao Tang, Shulin Chen, Ying Sun
OBJECTIVE: This study intends to study the association between serum retinol-binding protein 4 (RBP4), bone mineral density (BMD), and other bone metabolic related parameters in type 2 diabetic patients older than 50 years, with or without osteopenia or osteoporosis. METHODS: Patients (n = 274 cases) with type 2 diabetes, hospitalized in the Endocrinology Department of Yantai Yuhuangding Hospital from December 2015 to March 2017, were enrolled in the study. The bone mineral density (BMD) was recorded by the dual-energy X-ray absorptiometer, and patients were divided into normal bone mineral density group (148 cases), osteopenia (93 cases), and osteoporosis group (33 cases) group...
February 2, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29377041/use-of-a-web-portal-among-adult-clinic-patients-seen-for-type-2-diabetes-mellitus
#10
Steven S Coughlin, Vahé Heboyan, Lovoria B Williams, Christos Hatzigeorgiou
Background: To determine the number of adult clinic patients seen for type 2 diabetes mellitus (T2DM) at an academic medical center and to examine characteristics of those who had or had not registered for a web portal. Methods: Electronic records were reviewed to identify web portal registration by patients treated for T2DM by age, sex, race and Hispanic ethnicity, and service (General Internal Medicine, Endocrinology). Results: A total of 1,401 patients with T2DM were seen in General Internal Medicine and Endocrinology outpatient clinics...
January 2018: J Hosp Manag Health Policy
https://www.readbyqxmd.com/read/29371333/mechanisms-in-endocrinology-sglt2-inhibitors-clinical-benefits-by-restoration-of-normal-diurnal-metabolism
#11
Russell L Esterline, Allan Vaag, Jan Oscarsson, Jiten Vora
Type 2 diabetes (T2D) is associated with inhibition of autophagic and lysosomal housekeeping processes that detrimentally affect key organ functioning; a process likely to be exacerbated by conventional insulin-driven anabolic therapies. We propose that the cardio-renal benefits demonstrated with sodium-glucose cotransporter-2 inhibitor (SGLT2i) treatment in T2D partly may be explained by their ability to drive consistent, overnight periods of increased catabolism brought about by constant glucosuria. Key steps driving this catabolic mechanism include: a raised glucagon/insulin ratio initially depleting glycogen in the liver and ultimately activating gluconeogenesis utilizing circulating amino acids (AAs); a general fuel switch from glucose to free fatty acids (accompanied by a change in mitochondrial morphology from a fission to a sustained fusion state driven by a decrease in AA levels); a decrease in circulating AAs and insulin driving inhibition of mammalian target of rapamycin complex 1 (mTORC1), which enhances autophagy/lysosomal degradation of dysfunctional organelles, eventually causing a change in mitochondrial morphology from a fission to a sustained fusion state...
January 25, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29369757/telemedicine-in-the-management-of-type-1-diabetes
#12
Timothy Xu, Shreya Pujara, Sarah Sutton, Mary Rhee
BACKGROUND: Veterans with type 1 diabetes who live in rural Alabama and Georgia face barriers to receiving specialty diabetes care because of a lack of endocrinologists in the Central Alabama Veterans Health Care System. Telemedicine is a promising solution to help increase access to needed health care. We evaluated telemedicine's effectiveness in delivering endocrinology care from Atlanta-based endocrinologists. METHODS: We conducted a retrospective chart review of patients who were enrolled in the Atlanta VAMC Endocrinology Telehealth Clinic from June 2014 to October 2016...
January 25, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29368965/consensus-statement-by-the-american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-on-the-comprehensive-type-2-diabetes-management-algorithm-2018-executive-summary
#13
Alan J Garber, Martin J Abrahamson, Joshua I Barzilay, Lawrence Blonde, Zachary T Bloomgarden, Michael A Bush, Samuel Dagogo-Jack, Ralph A DeFronzo, Daniel Einhorn, Vivian A Fonseca, Jeffrey R Garber, W Timothy Garvey, George Grunberger, Yehuda Handelsman, Irl B Hirsch, Paul S Jellinger, Janet B McGill, Jeffrey I Mechanick, Paul D Rosenblit, Guillermo E Umpierrez
A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control Cardiovascular Risk in Diabetes; ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure; ACEI = angiotensin-converting enzyme inhibitor; ADVANCE = Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation; AGI = alpha-glucosidase inhibitor; apo B = apolipoprotein B; ASCVD = atherosclerotic cardiovascular disease; BAS = bile acid sequestrant; BCR-QR = bromocriptine quick release; BMI = body mass index; BP = blood pressure; CCB = calcium channel blocker; CHD = coronary heart disease; CKD = chronic kidney disease; CVD = cardiovascular disease; DASH = Dietary Approaches to Stop Hypertension; DPP4 = dipeptidyl peptidase 4; eGFR = estimated glomerular filtration rate; ER = extended release; FDA = Food and Drug Administration; GLP1 = glucagon-like peptide 1; HDL-C = high-density lipoprotein cholesterol; IMPROVE-IT = Improved Reduction of Outcomes: Vytorin Efficacy International Trial; LDL-C = low-density lipoprotein cholesterol; LDL-P = low-density lipoprotein particle; Look AHEAD = Look Action for Health in Diabetes; NPH = neutral protamine Hagedorn; OSA = obstructive sleep apnea; RCT = randomized controlled trial; SU = sulfonylurea; SGLT2 = sodium glucose cotransporter-2; SMBG = self-monitoring of blood glucose; T2D = type 2 diabetes; TZD = thiazolidinedione; VADT = Veterans Affairs Diabetes Trial...
January 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29363000/pituitary-xanthogranulomas-clinical-features-radiological-appearances-and-post-operative-outcomes
#14
R Ved, N Logier, P Leach, J S Davies, C Hayhurst
BACKGROUND: Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operatively. Their radiological imaging features are yet to be clearly defined, and clinical outcomes after surgery are also uncertain. This study reviews clinical presentation, radiological appearances, and clinical outcomes in a cohort of patients with pituitary xanthogranulomas...
January 23, 2018: Pituitary
https://www.readbyqxmd.com/read/29358046/clinical-course-of-a-cohort-with-type-2-diabetes-mellitus-after-endocrine-assessment-a-26-week-study
#15
Sandra Herranz-Antolín, Visitación Álvarez-de Frutos, Miguel Torralba
OBJECTIVE: To assess the degree of metabolic control and hypoglycemic treatments in a cohort of patients with type 2 diabetes mellitus (T2DM) after evaluation in an endocrinology clinic. MATERIAL AND METHODS: A prospective cohort study on 465 patients with T2DM who were not being monitored at an endocrinology clinic. Blood glucose control data and treatments received were recorded at an initial visit and after 26 weeks of follow-up. RESULTS: Baseline glycosylated hemoglobin (HbA1c) level was 8...
January 18, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29353709/the-role-of-telenursing-in-the-management-of-diabetes-type-1-a-randomized-controlled-trial
#16
Konstantia Kotsani, Vasiliki Antonopoulou, Aikaterini Kountouri, Maria Grammatiki, Eleni Rapti, Spyridon Karras, Christina Trakatelli, Panagiotis Tsaklis, Kiriakos Kazakos, Kalliopi Kotsa
BACKGROUND: Diabetes Mellitus type 1 (T1DM) is a chronic disease that requires patients' self-monitoring and self-management to achieve glucose targets and prevent complications. Telenursing implicates technology in the interaction of a specialized nurse with patients with chronic diseases in order to provide personalized care and support. OBJECTIVE: To evaluate the effect of telenursing on T1DM patients' compliance with glucose self-monitoring and glycemic control...
January 6, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29327527/role-and-relevance-of-blood-pressure-variability-in-hypertension-related-co-morbidities
#17
Ashok Kumar, B C Kalmath, Georgi Abraham, Johann Christopher, Pln Kaparthi, Louie Fischer, Neeta Deshpande, N K Mishra, Praveen Raj, Rajesh Javerani, Ramesh Goyal, Reefa Dsouza, Shashank R Joshi
Despite maintaining mean blood pressure at optimal levels, cardiovascular complications still occur in hypertensive patients. Blood pressure variability (BPV) has been implicated as a prominent factor responsible for incurring this additional risk. In this review we attempted to generate a consensus on the importance of BPV in the hypertension management and to evaluate different therapeutic options available to reduce BPV. Panel comprising of 11 leading experts from India in different areas of clinical practice (including nephrology, diabetes and endocrinology, cardiology, and critical care medicine) was convened...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29322398/hepatitis-c-virus-infection-and-development-of-type-2-diabetes-mellitus-systematic-review-and-meta-analysis-of-the-literature
#18
REVIEW
Silvia Fabiani, Poupak Fallahi, Silvia Martina Ferrari, Mario Miccoli, Alessandro Antonelli
Type 2 diabetes mellitus (T2DM) is an endocrine disorder encompassing multifactorial mechanisms, and chronic hepatitis C virus infection (CHC) is a multifaceted disorder, associated with extrahepatic manifestations, including endocrinological disorders. CHC and T2DM are associated, but the subject remains controversial. We performed a systematic review and meta-analysis evaluating such association, searching on PubMed until February 29, 2016. Inclusion criteria were: 1) presence of at least one internal control group age- and gender-matched (non-hepatopathic controls; and/or hepatopathic, not HCV-positive, controls); 2) sufficient data to calculate odds ratio and relative risk...
January 11, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29313284/endocrinological-aspects-of-hiv-infection
#19
REVIEW
F S Mirza, P Luthra, L Chirch
PURPOSE: Patients with human immunodeficiency virus (HIV) are living longer with effective antiretroviral therapies and are enjoying near normal life span. Therefore, they are encountering endocrine issues faced by the general population along with those specific to HIV infection. The purpose of this article is to review the common endocrine aspects of HIV infection, and the early detection and management strategies for these complications. METHODS: Recent literature on HIV and endocrine disease was reviewed...
January 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29288564/luteinizing-hormone-and-insulin-resistance-in-menopausal-patients-with-adrenal-incidentalomas-the-cause-effect-relationship
#20
Ljiljana V Marina, Miomira Ivović, Milina Tančić-Gajić, Zorana Arizanović, Dragana Raković, Jelena Milin-Lazović, Aleksandra Kendereški, Dragan Micić, Svetlana Vujović
OBJECTIVE: A high prevalence of insulin resistance (IR) has proven to manifest in patients with adrenal incidentalomas (AI). It has been demonstrated that an increase in IR is related to the size of tumourous masses; additionally, luteinizing hormone (LH) dependent adrenal pathologies are well documented in patients with LH responsive adrenal tumours occurring under conditions of physiologically elevated LH. We hypothesized that an association between LH and insulin might play a role in adrenal tumourigenesis and steroidogenesis...
December 30, 2017: Clinical Endocrinology
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