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https://www.readbyqxmd.com/read/29356196/complexes-of-stiboranium-mono-di-and-tri-cations
#1
Neil Burford, Christopher Frazee, Robert McDonald, Michael Ferguson, Brian Patrick, Andreas Decken
Reaction of Ph2SbCl3 with 2,2'-bipyridine and Me3SiOSO2CF3 releases chlorobenzene, which is interpreted as a reductive (SbV/SbIII) elimination from a cationic complex of a stiboranium cation. Conversely, reactions of Ph2SbCl3 with 4-methylpyridine-N-oxide and AgOSO2CF3 give redox resistant complexes with the generic formulae [Ph2SbCl3-xLx+1][OTf]x, including a compound containing the first example of a pnictogen(V) trication.
January 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29355782/an-ultrasensitive-competitive-immunosensor-using-silica-nanoparticles-as-an-enzyme-carrier-for-simultaneous-impedimetric-detection-of-tetrabromobisphenol-a-bis-2-hydroxyethyl-ether-and-tetrabromobisphenol-a-mono-hydroxyethyl-ether
#2
Zhen Zhang, Shuaibing Dong, Daohan Ge, Nuanfei Zhu, Kun Wang, Gangbing Zhu, Wanzhen Xu, Hai Xu
Based on our produced polyclonal antibody capable of recognizing tetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA-DHEE) and tetrabromobisphenol A mono(hydroxyethyl) ether (TBBPA-MHEE) (cross-reactivity, 100% for TBBPA DHEE; 98.7% for TBBPA MHEE), an important derivative and byproduct of tetrabromobisphenol A (TBBPA), respectively, a novel ultrasensitive competitive immunosensor was established using an electrochemical impedimetric strategy for the simultaneous detection of both chemicals. A significantly amplified electrochemical impedance spectroscopy (EIS) for quantitative target analysis was obtained through (i) the biocatalytic precipitation of 4-chloro-1-naphthol (CN) on the electrode surface triggered by horseradish peroxidase (HRP) and (ii) increased amounts of the enzyme with HRP-loaded silica nanoparticles carrying poly-brushes (SiO2@PAA) as labels, achieving a remarkable improvement in catalytic performance...
January 17, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29355688/metabolomics-profiling-of-steatosis-progression-in-heparg%C3%A2-cells-using-sodium-valproate
#3
Matthias Cuykx, Leen Claes, Robim M Rodrigues, Tamara Vanhaecke, Adrian Covaci
Non-alcoholic Fatty Liver Disease (NAFLD) is a frequently encountered Drug-Induced Liver Injury (DILI). Although this stage of the disease is reversible, it can lead to irreversible damage provoked by non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Therefore, the assessment of NAFLD is a paramount objective in toxicological screenings of new drug candidates. In this study, a metabolomic fingerprint of NAFLD induced in HepaRG® cells at four dosing schemes by a reference toxicant, sodium valproate (NaVPA), was obtained using liquid-liquid extraction followed by liquid chromatography and accurate mass-mass spectrometry (LC-AM/MS)...
January 17, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29355505/glutazumab-a-novel-long-lasting-glp-1-anti-glp-1r-antibody-fusion-protein-exerts-anti-diabetic-effects-through-targeting-dual-receptor-binding-sites
#4
Caina Li, Miaomiao Yang, Xiaofeng Wang, Hua Zhang, Chenjiang Yao, Sujuan Sun, Quan Liu, Hao Pan, Shuainan Liu, Yi Huan, Shengnan Li, Jun Cao, Xing Wang, Yong Guo, Nan Guo, Shuqian Jing, Cheng Zhang, Zhufang Shen
AIMS: Glucagon like-peptide-1 (GLP-1)-based drugs have been proposed as mono- or combined therapy for type 2 diabetes mellitus. Thus we characterized a novel antibody fusion protein engineered by linking the human GLP-1 derivative to a humanized GLP-1 receptor (GLP-1R) antibody via a peptide linker. MATERIALS AND METHODS: Glutazumab was characterized by receptor binding and reporter activation assays, and its specificity was investigated with the aid of the cognate receptor antagonist exendin (9-39) and antibody Ab1...
January 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29354839/effects-of-adatom-and-gas-molecule-adsorption-on-the-physical-properties-of-tellurene-a-first-principles-investigation
#5
Xiao Hua Wang, Da Wei Wang, Ai Jun Yang, Nikhil Koratkar, Ji Feng Chu, Pin Lei Lv, Ming Zhe Rong
Tellurene is a new member of the two-dimensional (2D) materials' family, whose existence has been recently confirmed by first principles calculation and experimental work. Tellurene is also the first 2D mono-elemental material of group-VI predicted by scientists, and investigations of its basic properties are still in their infancy. In this study, we use first principles calculation based on density functional theory to investigate the adsorption of nineteen typical adatoms (Li, Na, K, Ca, Fe, Co, Ni, Cu, Zn, Ag, Au, Pd, Pt, B, N, O, Si, Cl, and Al), and five typical gas molecules (H2, O2, H2O, NO2, and NH3) on α-phase as well as β-phase tellurene sheets...
January 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29353758/development-of-mixed-bacterial-cultures-dak11-capable-for-degrading-mixture-of-polycyclic-aromatic-hydrocarbons-pahs
#6
Avani Bharatkumar Patel, Krutika Mahala, Kunal Jain, Datta Madamwar
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and persistent pollutants having mutagenic and carcinogenic properties. Microbial metabolism is an alternative approach for removal of PAHs from polluted environment. Mixed bacterial cultures DAK11 capable for degrading mixture of PAHs was developed from long term polluted marine sediments. DAK11 was able to degrade 500 mg/L of mixture of four PAHs and their degradation efficiency was enhanced by supplementing commercially available NPK fertilizer (0...
January 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29352234/bi-exponential-3d-t1%C3%AF-mapping-of-whole-brain-at-3%C3%A2-t
#7
Rajiv G Menon, Azadeh Sharafi, Johannes Windschuh, Ravinder R Regatte
Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer's, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351291/allometric-biomass-equations-for-12-tree-species-in-coniferous-and-broadleaved-mixed-forests-northeastern-china
#8
Huaijiang He, Chunyu Zhang, Xiuhai Zhao, Folega Fousseni, Jinsong Wang, Haijun Dai, Song Yang, Qiang Zuo
Understanding forest carbon budget and dynamics for sustainable resource management and ecosystem functions requires quantification of above- and below-ground biomass at individual tree species and stand levels. In this study, a total of 122 trees (9-12 per species) were destructively sampled to determine above- and below-ground biomass of 12 tree species (Acer mandshuricum, Acer mono, Betula platyphylla, Carpinus cordata, Fraxinus mandshurica, Juglans mandshurica, Maackia amurensis, P. koraiensis, Populus ussuriensis, Quercus mongolica, Tilia amurensis and Ulmus japonica) in coniferous and broadleaved mixed forests of Northeastern China, an area of the largest natural forest in the country...
2018: PloS One
https://www.readbyqxmd.com/read/29350812/a-unified-framework-of-plant-adaptive-strategies-to-drought-crossing-scales-and-disciplines
#9
Florence Volaire
Plant adaptation to drought has been extensively studied at many scales from ecology to molecular biology across a large range of model species. However, the conceptual frameworks underpinning the definition of plant strategies, and the terminology used across the different disciplines and scales are not analogous. 'Drought resistance' for instance refers to plant responses as different as the maintenance of growth and productivity in crops, to the survival and recovery in perennial woody or grassland species...
January 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29348625/universal-type-subtype-specific-antibodies-for-quantitative-analyses-of-neuraminidase-in-trivalent-influenza-vaccines
#10
Kangwei Xu, Changgui Li, Caroline Gravel, Zheng Jiang, Bozena Jaentschke, Gary Van Domselaar, Xuguang Li, Junzhi Wang
Both influenza viral hemagglutinin and neuraminidase can induce protective immune responses in humans. Although the viral hemagglutinin antigens have been quantified in influenza vaccines, the amounts of neuraminidase remain undetermined. Using comprehensive bioinformatics analyses of all neuraminidase sequences, we identified highly conserved and subtype-specific peptide epitopes within each of N1, N2 and type B neuraminidase groups. Mono-specific antibodies generated against these peptides bound to their respective subtype/type only while demonstrating remarkable specificity against the viral neuraminidase sequences without any cross-reactivity with allantoic and cellular proteins...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348071/a-focused-fragment-library-targeting-the-antibiotic-resistance-enzyme-oxacillinase-48-synthesis-structural-evaluation-and-inhibitor-design
#11
Sundus Akhter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit, Hanna-Kirsti S Leiros, Annette Bayer
β-Lactam antibiotics are of utmost importance when treating bacterial infections in the medical community. However, currently their utility is threatened by the emergence and spread of β-lactam resistance. The most prevalent resistance mechanism to β-lactam antibiotics is expression of β-lactamase enzymes. One way to overcome resistance caused by β-lactamases, is the development of β-lactamase inhibitors and today several β-lactamase inhibitors e.g. avibactam, are approved in the clinic. Our focus is the oxacillinase-48 (OXA-48), an enzyme reported to spread rapidly across the world and commonly identified in Escherichia coli and Klebsiella pneumoniae...
December 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29346989/generation-of-droplet-arrays-with-rational-number-spacing-patterns-driven-by-a-periodic-energy-landscape
#12
Anatoly Rinberg, Georgios Katsikis, Manu Prakash
The generation of droplets at low Reynolds numbers is driven by nonlinear dynamics that give rise to complex patterns concerning both the droplet-to-droplet spacing and the individual droplet sizes. Here we demonstrate an experimental system in which a time-varying energy landscape provides a periodic magnetic force that generates an array of droplets from an immiscible mixture of ferrofluid and silicone oil. The resulting droplet patterns are periodic, owing to the nature of the magnetic force, yet the droplet spacing and size can vary greatly by tuning a single bias pressure applied on the ferrofluid phase; for a given cycle period of the magnetic force, droplets can be generated either at integer multiples (1, 2, ...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346731/direct-polymerization-of-the-arsenic-drug-penao-to-obtain-nanoparticles-with-high-thiol-reactivity-and-anti-cancer-efficiency
#13
Janina-Miriam Noy, Hongxu Lu, Philip Hogg, Jia-Lin Yang, Martina H Stenzel
PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid), which is a mitochondria inhibitor that reacts with adenine nucleotide translocator (ANT), is currently being trialed in patients with solid tumors. To increase the stability of the drug, the formation of nanoparticles has been proposed. Herein, the direct synthesis of polymeric micelles based on the anti-cancer drug PENAO is presented. PENAO is readily available for amidation reaction to form PENAO MA (4-(N-(S-penicillaminylacetyl) amino) phenylarsonous acid methacrylamide) which undergoes RAFT (reversible addition fragmentation chin transfer) polymerization with poly(polyethylene glycol methyl ether methacrylate) (PEGMA) as comonomer and poly(methylmethacrylate) (pMMA) as chain transfer agent, resulting in p(MMA)-b-p(PEG-co-PENAO) block copolymers with 3-15 wt...
January 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29346585/maternal-vaccination-with-a-mono-component-pertussis-toxoid-vaccine-is-sufficient-to-protect-infants-in-a-baboon-model-of-whooping-cough
#14
Parul Kapil, James F Papin, Roman F Wolf, Lindsey I Zimmerman, Leslie D Wagner, Tod J Merkel
Background: Bordetella pertussis is a human pathogen responsible for serious respiratory illness. The disease is most severe in infants too young to be vaccinated with most hospitalizations and deaths occurring within this age group. The Advisory Committee on Immunization Practices recommended immunization of pregnant women to protect infants from birth until their first vaccination at six to eight weeks of age. We previously demonstrated that maternal vaccination with licensed acellular pertussis vaccines protected newborn baboons from disease...
January 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29346443/exposure-to-previous-cart-is-associated-with-significant-liver-fibrosis-and-cirrhosis-in-human-immunodeficiency-virus-infected-patients
#15
Evrim Anadol, Kristina Lust, Christoph Boesecke, Carolynne Schwarze-Zander, Raphael Mohr, Jan-Christian Wasmuth, Jürgen Kurt Rockstroh, Jonel Trebicka
INTRODUCTION: Combined antiretroviral therapy (cART) has improved survival in HIV-patients. While the first antiretrovirals, which became available in particular D-drugs (especially didanosine and stavudine) and unboosted protease inhibitors, may impair liver function, the modern cART seems to decrease liver fibrosis. This study assessed the influence of exposure to previous antiretrovirals on liver fibrosis in HIV-infected patients. METHODS: This observational cross-sectional single-center study recruited 333 HIV patients and assessed liver fibrosis using transient elastography (TE)...
2018: PloS One
https://www.readbyqxmd.com/read/29345255/pure-mechanistic-analysis-of-additive-neuroprotective-effects-between-baicalin-and-jasminoidin-in-ischemic-stroke-mice
#16
Peng-Qian Wang, Qiong Liu, Wen-Juan Xu, Ya-Nan Yu, Ying-Ying Zhang, Bing Li, Jun Liu, Zhong Wang
Both baicalin (BA) and jasminoidin (JA) are active ingredients in Chinese herb medicine Scutellaria baicalensis and Fructus gardeniae, respectively. They have been shown to exert additive neuroprotective action in ischemic stroke models. In this study we used transcriptome analysis to explore the pure therapeutic mechanisms of BA, JA and their combination (BJ) contributing to phenotype variation and reversal of pathological processes. Mice with middle cerebral artery obstruction were treated with BA, JA, their combination (BJ), or concha margaritifera (CM)...
January 18, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29345044/preclinical-characterisation-of-absorption-distribution-metabolism-and-excretion-properties-of-tak-063
#17
Kimio Tohyama, Miyako Sudo, Akio Morohashi, Suguru Kato, Junzo Takahashi, Yoshihiko Tagawa
TAK-063 is currently being developed to treat schizophrenia. In this study, we investigated the absorption, distribution, metabolism and excretion (ADME) properties of TAK-063 using several paradigms. Following oral administration of TAK-063 at 0.3 mg/kg, bioavailability of TAK-063 was 27.4% in rats and 49.5% in dogs with elimination half-lives of 3.1 hr in rats and 3.7 hr in dogs. TAK-063 is a highly permeable compound without P-glycoprotein (P-gp) or breast cancer resistance protein substrate liability and can be readily absorbed into systemic circulation via the intestine...
January 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29343750/multi-wavelength-growth-of-nanosecond-laser-induced-surface-damage-on-fused-silica-gratings
#18
Maxime Chambonneau, Laurent Lamaignère
The nanosecond laser-induced damage growth phenomenon on the exit surface of fused silica grating is investigated at 1064 nm and 355 nm separately and also simultaneously. Experiments are first carried out on damage sites on a plane fused silica sample showing two different morphologies, and a damage type is selected for ensuring the repeatability of the subsequent tests. Comparing the mono-wavelength growth results on a grating and a plane fused silica sample, the periodic surface structure is found to be an aggravating factor for damage growth...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343187/mechanical-and-antibacterial-properties-of-benzothiazole-based-dental-resin-materials
#19
Wenbin Zhu, Chonghui Lao, Shuzhen Luo, Fang Liu, Qiting Huang, Jingwei He, Zhengmei Lin
A synthesized benzothiazole containing mono-methacrylate monomer BTTMA was incorporated into Bis-GMA/TEGDMA dental resin system with a series of mass concentration from 5 wt.% to 30 wt.% as an antibacterial agent. The influence of BTTMA on physicochemical properties of dental resin system, such as double bond conversion (DC), volumetric shrinkage (VS), flexural strength (FS) and modulus (FM), water sorption (WS) and solubility (SL) were investigated. Direct contact testing and agar diffusion testing were used to evaluate the antibacterial activity of BTTMA containing dental resin...
January 17, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29343012/-the-effectiveness-of-individualized-treatment-regimen-on-smear-positive-retreatment-pulmonary-tuberculosis-with-mono-and-poly-drug-resistance
#20
Y H Liu, W W Gao, L Li, J Du, Y Ma, W Shu, X Y Lyu, S H Xie, H H Wang, T Chen
Objective: To analyze and evaluate the effectiveness of individualized treatment regimen in the therapy of smear-positive retreatment pulmonary tuberculosis with mono-and poly-drug resistance, and therefor to provide information on how to develop rational individualized regimen for retreatment tuberculosis cases with drug resistance. Methods: This was a multi-centered, prospective cohort study. Totally 254 cases of sputum positive tuberculosis with previous treatment history during the period from July 1, 2009 to August 30, 2016 were included in the analysis...
January 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
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