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https://www.readbyqxmd.com/read/27931719/a-potential-pitfall-in-evaluating-her2-immunohistochemistry-for-gastric-signet-ring-cell-carcinomas
#1
Chang Gok Woo, Won Jin Ho, Young Soo Park, Sook Ryun Park, Min-Hee Ryu, Hwoon-Yong Jung, Yoon-Koo Kang
Signet ring cell carcinoma (SRC) more commonly presents as metastatic disease and renders patients to be considered for chemotherapy. While treatment options are limited overall, trastuzumab has been shown to be effective for HER2 positive SRC cases. The current algorithm for HER2 evaluation heavily relies on positive membrane-specific staining by immunohistochemistry (IHC), but several anecdotal reports have suggested that SRCs may be susceptible to misinterpretation due to non-specific staining in the marginated cytoplasm with/without nucleus...
December 5, 2016: Pathology
https://www.readbyqxmd.com/read/27928625/stereotactic-radiotherapy-of-vestibular-schwannoma-hearing-preservation-vestibular-function-and-local-control-following-primary-and-salvage-radiotherapy
#2
Florian Putz, Jan Müller, Caterina Wimmer, Nicole Goerig, Stefan Knippen, Heinrich Iro, Philipp Grundtner, Ilker Eyüpoglu, Karl Rössler, Sabine Semrau, Rainer Fietkau, Sebastian Lettmaier
OBJECTIVE: The aim of this publication is to present long-term data on functional outcomes and tumor control in a cohort of 107 patients treated with stereotactic radiotherapy (RT) for vestibular schwannoma. PATIENTS AND METHODS: Included were 107 patients with vestibular schwannoma (primary or recurrent following resection) treated with stereotactic RT (either fractioned or single-dose radiosurgery) between October 2002 and December 2013. Local control and functional outcomes were determined...
December 7, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27928514/a-microchip-for-high-throughput-axon-growth-drug-screening
#3
Hyun Soo Kim, Sehoon Jeong, Chiwan Koo, Arum Han, Jaewon Park
It has been recently known that not only the presence of inhibitory molecules associated with myelin but also the reduced growth capability of the axons limit mature central nervous system (CNS) axonal regeneration after injury. Conventional axon growth studies are typically conducted using multi-well cell culture plates that are very challenging to investigate localized effects of drugs and limited to low throughput. Unfortunately, there is currently no other in vitro tools that allow investigating localized axonal responses to biomolecules in high-throughput for screening potential drugs that might promote axonal growth...
July 2016: Micromachines
https://www.readbyqxmd.com/read/27928209/the-value-of-visa-score-and-colour-flow-imaging-in-the-follow-up-of-non-athletes-operated-for-jumpers-knee
#4
Eirik S Salvesen, Ketil J Holen
The objective of this study was to assess if the Victorian Institute of Sport Assessment (VISA) questionnaire was suitable in the evaluation of patients from a mixed population with normal levels of sports activity, and if neovascularization of the patellar tendon demonstrated by color flow imaging (CFI) was more frequent in patients with lasting symptoms after surgical treatment for jumpers knee (JK). This study was conducted at St. Olavs Hospital, University Hospital of Trondheim, Norway, and included 21 men and 18 women who were operated for JK...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27925376/animated-activity-questionnaire-aaq-a-new-method-of-self-reporting-activity-limitations-in-patients-with-hip-and-knee-osteoarthritis-comparisons-with-observation-by-spouses-for-construct-validity
#5
W F Peter, H S Dagfinrud, N Østerås, C B Terwee
OBJECTIVE: The aim of the present study was to evaluate the construct validity of the Animated Activity Questionnaire (AAQ) for measuring activity limitations of patients with hip and knee osteoarthritis (HKOA). DESIGN: In a psychometric design, data from HKOA patients and their spouses in Norway and the Netherlands were collected independently of each other, using the AAQ, the Function of Daily Living (FDL) subscale from the Hip disability or Knee injury Osteoarthritis Outcome Scale (H/KOOS) and the Numerical Rating Scale for pain (NRS-pain)...
December 7, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27924200/effect-of-recruitment-maneuver-on-arterial-oxygenation-in-patients-undergoing-robot-assisted-laparoscopic-prostatectomy-with-intraoperative-15-cmh2o-positive-end-expiratory-pressure
#6
Sowoon Ahn, Sung Hye Byun, Haeyoon Chang, Young Bin Koo, Jong Chan Kim
BACKGROUND: This randomized, controlled study was designed to compare the effects of recruitment maneuvers (RMs) with a 15 cmH2O positive end-expiratory pressure (PEEP) on the systemic oxygenation and lung compliance of patients with healthy lungs following robot-assisted laparoscopic prostatectomy (RALP). METHODS: Sixty patients undergoing a RALP with an intraoperative 15 cmH2O PEEP were randomly allocated to an RM or a Control group. The patients in the RM group received a single RM through the application of a continuous positive airway pressure of 40 cmH2O for 40 s 15 min after being placed in the Trendelenburg position...
December 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27923626/limitations-in-predicting-outcome-following-primary-acl-reconstruction-with-single-bundle-hamstring-autograft-a-systematic-review
#7
REVIEW
Vincent Vg An, Corey Scholes, Vikram A Mhaskar, William Hadden, David Parker
BACKGROUND: Anterior cruciate ligament reconstruction (ACLR) is one of the most well studied and performed procedures in the world. Thus, it would be useful to develop a tool to predict patient outcomes post-operatively to allow clinicians to optimise management. PURPOSE: To identify and summarise factors predictive of graft failure and patient-reported outcome (PROM) measures at minimum two years after ACLR with single-bundle quadruple hamstring autograft via the anteromedial portal technique...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27918221/neutrophilic-inflammation-in-asthma-mechanisms-and-therapeutic-considerations
#8
Hun Soo Chang, Tae-Hyeong Lee, Ji Ae Jun, Ae Rin Baek, Jong-Sook Park, So My Koo, Yang-Ki Kim, Ho Sung Lee, Choon-Sik Park
Neutrophilic airway inflammation represents a pathologically distinct form of asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical impacts and mechanisms of the neutrophilic inflammation have not been thoroughly evaluated up to date. Areas covered: Currently, distinct clinical manifestations, triggers, and molecular mechanisms of the neutrophilic inflammation (namely Toll-like receptor, Th1, Th17, inflammasome) are under investigation in asthma. Furthermore, possible role of the neutrophilic inflammation is being investigated in respect to the airway remodeling...
December 5, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27917453/phase-i-study-of-mrx34-a-liposomal-mir-34a-mimic-administered-twice-weekly-in-patients-with-advanced-solid-tumors
#9
Muhammad S Beg, Andrew J Brenner, Jasgit Sachdev, Mitesh Borad, Yoon-Koo Kang, Jay Stoudemire, Susan Smith, Andreas G Bader, Sinil Kim, David S Hong
Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the expression of >30 oncogenes across multiple oncogenic pathways, as well as genes involved in tumor immune evasion, but is lost or under-expressed in many malignancies. This first-in-human, phase I study assessed the maximum tolerated dose (MTD), safety, pharmacokinetics, and clinical activity of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumors. Patients and Methods Adult patients with solid tumors refractory to standard treatment were enrolled in a standard 3 + 3 dose escalation trial...
December 5, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27915200/effects-of-prophylactic-indomethacin-on-vasopressor-dependent-hypotension-in-extremely-preterm-infants
#10
Melissa Liebowitz, Jane Koo, Andrea Wickremasinghe, Isabel Elaine Allen, Ronald I Clyman
OBJECTIVE: To determine whether a moderate-to-large patent ductus arteriosus (PDA) is responsible for vasopressor-dependent hypotension, occurring at the end of the first postnatal week. STUDY DESIGN: We performed a retrospective, double cohort controlled study of infants delivered at ≤27(+6) weeks' gestation (n = 313). From January 2004 through April 2011, all infants were treated with prophylactic indomethacin ([PINDO] epoch). From May 2011 through December 2015, no infant was treated with indomethacin until at least 8 postnatal days (conservative epoch)...
December 1, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27915160/histone-deacetylase-9-plays-a-role-in-the-antifibrogenic-effect-of-astaxanthin-in-hepatic-stellate-cells
#11
Yue Yang, Minkyung Bae, Young-Ki Park, Yoojin Lee, Tho X Pham, Swetha Rudraiah, José Manautou, Sung I Koo, Ji-Young Lee
Activation of hepatic stellate cells (HSCs) is critical for liver fibrosis development. Previously, we showed that astaxanthin (ASTX), a xanthophyll carotenoid, has antifibrogenic effects in LX-2 cells, a human HSC cell line. We sought to determine the effect of ASTX on HSC activation, and to identify molecular mediators that are critically involved in the processes. ASTX prevented the activation of mouse primary HSCs, as evidenced by attenuated induction of procollagen type I α1. In human primary HSCs, ASTX also inhibited transforming growth factor β1 (TGFβ1)-induced fibrogenic gene expression...
November 12, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27914701/il-2-anti-il-2-complexes-ameliorate-lupus-nephritis-by-expansion-of-cd4-cd25-foxp3-regulatory-t%C3%A2-cells
#12
Ji-Jing Yan, Jae-Ghi Lee, Joon Young Jang, Tai Yeon Koo, Curie Ahn, Jaeseok Yang
Adoptive transfer of regulatory T cells (Tregs) can delay disease progression and reduce mortality in lupus-prone mice. Here, we tested whether complex (IL-2C) consisting of IL-2 and anti-IL-2 monoclonal antibody (JES6-1) ameliorates lupus nephritis by expanding Tregs as an alternative to problematic Treg infusion therapy. IL-2C treatment of NZB/W F1 mice induced an effective and sustained expansion of CD4(+)CD25(+)Foxp3(+) Tregs in both the kidneys and spleen along with decreased renal infiltration of T cells, B cells, and innate immune cells...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27913352/towards-zero-waste-furniture-design
#13
Bongjin Koo, Jean Hergel, Sylvain Lefebvre, Niloy Mitra
In traditional design, shapes are first conceived, and then fabricated. While this decoupling simplifies the design process, it can result in unwanted material wastage, especially where off-cut pieces are hard to reuse. In absence of explicit feedback on material usage, the designer remains helpless to effectively adapt the design - even when design variabilities exist.We investigate waste minimizing furniture design wherein based on the current design, the user is presented with design variations that result in less wastage of materials...
December 1, 2016: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27909815/homoeologous-recombination-in-the-presence-of-ph1-gene-in-wheat
#14
Dal-Hoe Koo, Wenxuan Liu, Bernd Friebe, Bikram S Gill
A crossover (CO) and its cytological signature, the chiasma, are major features of eukaryotic meiosis. The formation of at least one CO/chiasma between homologous chromosome pairs is essential for accurate chromosome segregation at the first meiotic division and genetic recombination. Polyploid organisms with multiple sets of homoeologous chromosomes have evolved additional mechanisms for the regulation of CO/chiasma. In hexaploid wheat (2n = 6× = 42), this is accomplished by pairing homoeologous (Ph) genes, with Ph1 having the strongest effect on suppressing homoeologous recombination and homoeologous COs...
December 1, 2016: Chromosoma
https://www.readbyqxmd.com/read/27908543/from-the-medical-board-of-the-national-psoriasis-foundation-treatment-targets-for-plaque-psoriasis
#15
April W Armstrong, Michael P Siegel, Jerry Bagel, Erin E Boh, Megan Buell, Kevin D Cooper, Kristina Callis Duffin, Lawrence F Eichenfield, Amit Garg, Joel M Gelfand, Alice B Gottlieb, John Y M Koo, Neil J Korman, Gerald G Krueger, Mark G Lebwohl, Craig L Leonardi, Arthur M Mandelin, M Alan Menter, Joseph F Merola, David M Pariser, Ronald B Prussick, Caitriona Ryan, Kara N Shah, Jeffrey M Weinberg, MaryJane O U Williams, Jashin J Wu, Paul S Yamauchi, Abby S Van Voorhees
BACKGROUND: An urgent need exists in the United States to establish treatment goals in psoriasis. OBJECTIVE: We aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice. METHODS: The National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds...
November 22, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27906385/structural-dynamics-general-discussion
#16
Piero Decleva, Andrew J Orr-Ewing, Markus Kowalewski, Oleg Kornilov, Jon P Marangos, Hans Jakob Wörner, Allan S Johnson, Ruaridh Forbes, Daniel Rolles, Dave Townsend, Oliver Schalk, Sebastian Mai, Tom J Penfold, R J Dwayne Miller, Martin Centurion, Kiyoshi Ueda, Wolfgang Domcke, Peter M Weber, Kyoung Koo Baeck, Oksana Travnikova, Chelsea Liekhus-Schmaltz, João Pedro Figueira Nunes, Daniel M Neumark, Oliver Gessner, Albert Stolow, Artem Rudenko, Pankaj Kumar Mishra, Adam Kirrander, Danielle Dowek, Fernando Martín, Ágnes Vibók, Michael P Minitti, Brian Stankus, Christian Burger
No abstract text is available yet for this article.
December 1, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27904223/talocalcaneal-coalition-a-focus-on-radiographic-findings-and-sites-of-bridging
#17
Soon Hyuck Lee, Hyung Jun Park, Eui Dong Yeo, Young Koo Lee
BACKGROUND: Verifying the exact location of talocalcaneal (TC) coalition is important for surgery, but the complicated anatomy of the subtalar joint makes it difficult to visualize on radiographs. No study has used computed tomography (CT) or magnetic resonance imaging (MRI) to verify the radiological characteristics of TC coalition or those of different facet coalitions. Therefore, this study verified the radiological findings used to identify TC coalitions and those of different facet coalitions using CT and MRI...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27903952/how-readable-is-bph-treatment-information-on-the-internet-assessing-barriers-to-literacy-in-prostate-health
#18
Kevin Koo, Ronald L Yap
Information about benign prostatic hyperplasia (BPH) has become increasingly accessible on the Internet. Though the ability to find such material is encouraging, its readability and impact on informing patient decision making are not known. To evaluate the readability of Internet-based information about BPH in the context of website ownership and Health on the Net certification, three search engines were queried daily for 1 month with BPH-related keywords. Website ownership data and Health on the Net certification status were verified...
November 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27903185/acute-clinical-adverse-radiation-effects-after-gamma-knife-surgery-for-vestibular-schwannomas
#19
Constantin Tuleasca, Mercy George, Mohamed Faouzi, Luis Schiappacasse, Henri-Arthur Leroy, Michele Zeverino, Roy Thomas Daniel, Raphael Maire, Marc Levivier
OBJECTIVE Vestibular schwannomas (VSs) represent a common indication of Gamma Knife surgery (GKS). While most studies focus on the long-term morbidity and adverse radiation effects (AREs), none describe the acute clinical AREs that might appear on a short-term basis. These types of events are investigated, and their incidence, type, and outcomes are reported in the present paper. METHODS The included patients were treated between July 2010 and March 2016, underwent at least 6 months of follow-up, and presented with a disabling symptom during the first 6 months after GKS that affected their quality of life...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27902980/gene-expression-profiling-and-functional-characterization-of-macrophages-in-response-to-circulatory-microparticles-produced-during-trypanosoma-cruzi-infection-and-chagas-disease
#20
Imran H Chowdhury, Sue-Jie Koo, Shivali Gupta, Lisa Yi Liang, Bojlul Bahar, Laura Silla, Julio Nuñez-Burgos, Natalia Barrientos, Maria Paola Zago, Nisha Jain Garg
BACKGROUND: Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of clinical disease. METHODS: MPs were harvested from supernatants of human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma of seropositive humans with a clinically asymptomatic (CA) or symptomatic (CS) disease state (vs...
December 1, 2016: Journal of Innate Immunity
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