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https://www.readbyqxmd.com/read/29783271/mid-term-clinical-outcome-and-reconstruction-of-posterior-tibial-slope-after-uka
#1
Alois Franz, Christoph Kolja Boese, Andrej Matthies, Jörg Leffler, Christian Ries
Unicompartmental knee arthroplasty (UKA) has gained growing popularity over the last decades. The posterior tibial slope (PTS) has been shown to play a significant role for knee biomechanics and is thought to be crucial for clinical function of the UKA. We evaluated the clinical outcome at mid-term follow-up after UKA. Furthermore, the reconstruction of the individual PTS was analyzed. A total of 91 consecutive patients undergoing medial UKA for osteoarthritis were included. Patients were contacted by telephone for a survival analysis at a minimum of 30 months after surgery...
May 21, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29781911/what-is-the-frequency-of-early-dissociation-of-bipolar-cups-and-what-factors-are-associated-with-dissociation
#2
Young-Kyun Lee, Chan Ho Park, Yong-Chan Ha, Kyung-Hoi Koo
BACKGROUND: Dissociation between a prosthetic cup and femoral head is a rare complication of bipolar hemiarthroplasty that usually occurs during closed reduction of a dislocated bipolar cup. The dissociation usually results in reoperation because closed reduction is challenging. To our knowledge, no study has reported on the frequency of bipolar cup-femoral head dissociation, and risk factors for dissociation are unknown. QUESTIONS/PURPOSES: The purposes of this study were (1) to evaluate the frequency of dissociation of prosthetic femoral heads from bipolar cups during manual reduction of a dislocated bipolar hemiarthroplasty; and (2) to explore in a preliminary fashion any prosthesis or patient factors that may be associated with dissociation...
May 17, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29781550/walking-gait-asymmetries-six-months-following-anterior-cruciate-ligament-reconstruction-predict-twelve-month-patient-reported-outcomes
#3
Brian Pietrosimone, J Troy Blackburn, Darin A Padua, Steven J Pfeiffer, Hope C Davis, Brittney A Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett S Frank, R Alexander Creighton, Ganesh M Kamath, Jeffery T Spang
The study sought to determine the association between gait biomechanics (vertical ground reaction force [vGRF], vGRF loading rate [vGRF-LR]) collected six months following anterior cruciate ligament reconstruction (ACLR) with patient-reported outcomes at twelve months following ACLR. Walking gait mechanics and all subsections of the Knee Injury and Osteoarthritis Outcomes Score (KOOS) were collected at six and twelve months following ACLR, respectively, in 25 individuals with a unilateral ACLR. Peak vGRF and peak instantaneous vGRF-LR were extracted from the first 50% of the stance phase...
May 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29780834/factors-affecting-the-achievement-of-a-patient-acceptable-symptom-state-1-year-after-anterior-cruciate-ligament-reconstruction-a-cohort-study-of-343-patients-from-2-registries
#4
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Alberto Grassi, Ferid Krupic, Roland Thomeé, Kristian Samuelsson
Background: There is insufficient knowledge regarding the influence of concomitant injuries on the recovery of short-term subjective knee function after anterior cruciate ligament (ACL) reconstruction. Purpose: To determine whether patient characteristics, concomitant injuries, and graft choice during ACL reconstruction can predict which patients achieve acceptable knee function 1 year after reconstruction. Study Design: Case-control study; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29779598/metabolic-myopathies-and-the-respiratory-system
#5
REVIEW
Patrick Koo, Jigme M Sethi
Metabolic myopathies are a heterogeneous group of disorders characterized by inherited defects of enzymatic pathways involved in muscle cellular energetics and adenosine triphosphate synthesis. Skeletal and respiratory muscles are most affected. There are multiple mechanisms of disease. The age of onset and prognosis vary. Metabolic myopathies cause exercise intolerance, myalgia, and increase in muscle breakdown products during exercise. Some affect smooth muscle like the diaphragm and cause respiratory failure...
June 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29779365/hierarchical-metal-organic-framework-assembled-membrane-filter-for-efficient-removal-of-particulate-matter
#6
Won-Tae Koo, Ji-Soo Jang, Shaopeng Qiao, Wontae Hwang, Gaurav Jha, Reginald M Penner, Il-Doo Kim
Here, we propose heterogeneous nucleation assisted hierarchical growth of metal-organic framework (MOF) for efficient particulate matter (PM) removal. The assembly of 2-dimensional (2D) Zn based zeolite imidazole framework (2D-ZIF-L) in deionized water over a period time produced hierarchical ZIF-L (H-ZIF-L) on hydrophilic substrates. During the assembly, the 2nd nucleation and growth of ZIF-L occurred on the surface of 1st ZIF-L, leading to the formation of flower-like H-ZIF-L on the substrate. The flower-like H-ZIF-L was easily synthesized on various substrates, including glass, polyurethane 3D foam, nylon microfibers, and non-woven fabrics...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29777731/tumor-necrosis-factor-receptor-2-is-required-for-ischemic-preconditioning-mediated-neuroprotection-in-the-hippocampus-following-a-subsequent-longer-transient-cerebral-ischemia
#7
Jae-Chul Lee, Chan Woo Park, Myoung Cheol Shin, Jun Hwi Cho, Hyang-Ah Lee, Young-Myeong Kim, Joon Ha Park, Ji Hyeon Ahn, Jeong Hwi Cho, Hyun-Jin Tae, In Koo Hwang, Tae-Kyeong Lee, Moo-Ho Won, Il Jun Kang
Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine implicated in neuronal damage in response to cerebral ischemia. Ischemic preconditioning (IPC) provides neuroprotection against a subsequent severer or longer transient ischemia by ischemic tolerance. Here, we focused on the role of TNF-α in IPC-mediated neuroprotection against neuronal death following a subsequent longer transient cerebral ischemia (TCI). Gerbils used in this study were randomly assigned to eight groups; sham group, TCI operated group, IPC plus (+) sham group, IPC + TCI operated group, sham + etanercept (an inhibitor of TNF-a) group, TCI + etanercept group, IPC + sham + etanercept group, and IPC + TCI + etanercept group...
May 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29777684/repositioning-of-anti-cancer-drug-candidate-azd7762-to-an-anti-allergic-drug-suppressing-ige-mediated-mast-cells-and-allergic-responses-via-the-inhibition-of-lyn-and-fyn
#8
Young Hwan Park, Do Kyun Kim, Hyun Woo Kim, Hyuk Soon Kim, Dajeong Lee, Min Bum Lee, Keun Young Min, Jimo Koo, Su Jeong Kim, Changhee Kang, Young Mi Kim, Hyung Sik Kim, Wahn Soo Choi
Mast cells are critical effector cells in IgE-mediated allergic responses. The aim of this study was to investigate the anti-allergic effects of 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide (AZD7762) in vitro and in vivo. AZD7762 inhibited the antigen-stimulated degranulation from RBL-2H3 (IC50 , ∼ 27.9 nM) and BMMCs (IC50 , ∼ 99.3 nM) in a dose-dependent manner. AZD7762 also inhibited the production of TNF-α and IL-4. As the mechanism of its action, AZD7762 inhibited the activation of Syk and its downstream signaling proteins, such as Linker of activated T cells (LAT), phospholipase (PL) Cγ1, Akt, and mitogen-activated protein (MAP) kinases (Erk1 / 2, p38, and JNK) in mast cells...
May 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29777359/regulatory-mechanisms-of-thiol-based-redox-sensors-lessons-learned-from-structural-studies-on-prokaryotic-redox-sensors
#9
REVIEW
Sang Jae Lee, Dong-Gyun Kim, Kyu-Yeon Lee, Ji Sung Koo, Bong-Jin Lee
Oxidative stresses, such as reactive oxygen species, reactive electrophilic species, reactive nitrogen species, and reactive chlorine species, can damage cellular components, leading to cellular malfunction and death. In response to oxidative stress, bacteria have evolved redox-responsive sensors that enable them to simultaneously monitor and eradicate potential oxidative stress. Specifically, redox-sensing transcription regulators react to oxidative stress by means of modifying the thiol groups of cysteine residues, functioning as part of an efficient survival mechanism for many bacteria...
May 17, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29775275/a-high-performance-and-recyclable-al-air-coin-cell-based-on-eco-friendly-chitosan-hydrogel-membranes
#10
Yisi Liu, Qian Sun, Xiaofei Yang, Jianneng Liang, Biqiong Wang, Alicia Koo, Ruying Li, Jie Li, Xueliang Sun
Aluminum-air batteries are a promising power supply for electronics due to its low cost and high energy density. However, portable coin-type Al-air batteries operating under ambient air condition for small electronic appliances have rarely been reported. Herein, coin cell-type Al-air batteries using cost-effective and eco-friendly chitosan hydrogel membranes modified by SiO2, SnO2, and ZnO have been prepared and assembled. The Al-air coin cell employing chitosan hydrogel membrane containing 10 wt.% SiO2 as a separator exhibits better discharge performance with a higher flat voltage plateau, longer discharge duration, and higher power density than the cells using a chitosan hydrogel membrane containing SnO2 or ZnO...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29775160/site-specific-expression-of-amine-oxidases-in-breast-cancer-metastases
#11
Yoon Jin Cha, Woo Hee Jung, Ja Seung Koo
We aimed to evaluate the expression of amine oxidase-related proteins in metastatic breast cancer tissue and determine its clinical implication. A tissue microarray was constructed from a total of 126 metastatic breast tumors (31 bone metastases (24.6%), 36 brain metastases (28.6%), 11 liver metastases (8.7%), and 48 lung metastases (38.1%)). Immunohistochemical staining for amine oxidase-related proteins (lysyl oxidase, diamine oxidase, and monoamine oxidase A and B) was performed. In metastatic breast cancer tissue, lysyl oxidase ( p = 0...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29775147/intraoperative-cochlear-nerve-mapping-with-the-mobile-cochlear-nerve-compound-action-potential-tracer-in-vestibular-schwannoma-surgery
#12
Nobuyuki Watanabe, Takuya Ishii, Kazuhiko Fujitsu, Shogo Kaku, Teruo Ichikawa, Kosuke Miyahara, Tomu Okada, Shin Tanino, Yasuhiro Uriu, Yuichi Murayama
OBJECTIVE The authors describe the usefulness and limitations of the cochlear nerve compound action potential (CNAP) mobile tracer (MCT) that they developed to aid in cochlear nerve mapping during vestibular schwannoma surgery (VSS) for hearing preservation. METHODS This MCT device requires no more than 2 seconds for stable placement on the nerve to obtain the CNAP and thus is able to trace the cochlear nerve instantaneously. Simultaneous bipolar and monopolar recording is possible. The authors present the outcomes of 18 consecutive patients who underwent preoperative useful hearing (defined as class I or II of the Gardner-Robertson classification system) and underwent hearing-preservation VSS with the use of the MCT...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29774160/underwater-endoscopic-colorectal-polyp-resection-feasibility-in-everyday-clinical-practice
#13
Sergio Cadoni, Mauro Liggi, Paolo Gallittu, Donatella Mura, Lorenzo Fuccio, Malcolm Koo, Sauid Ishaq
Background: Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of single and/or tertiary-care referral centers, with single or supervised operators. Objective: The purpose of this study was to determine feasibility and efficacy of underwater resection of polyps of any morphology (underwater polypectomy, here includes underwater endoscopic mucosal resection) in routine clinical practice...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29773458/outcomes-of-conventional-phacoemulsification-versus-femtosecond-laser-assisted-cataract-surgery-in-eyes-with-fuchs-endothelial-corneal-dystrophy
#14
Dagny C Zhu, Parth Shah, William J Feuer, Wei Shi, Ellen H Koo
PURPOSE: To compare the outcomes in eyes with Fuchs endothelial corneal dystrophy after standard phacoemulsification with those of femtosecond laser-assisted cataract surgery. SETTING: Bascom Palmer Eye Institute, Miami, Florida, USA. DESIGN: Retrospective case series. METHODS: Charts from patients diagnosed with Fuchs endothelial corneal dystrophy who had phacoemulsification cataract surgery at Bascom Palmer Eye Institute between January 1, 2014, and January 1, 2017, were reviewed...
May 15, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29772938/the-suppressive-effect-of-the-three-herb-extract-mixture-on-vascular-and-liver-inflammation-in-atherogenic-diet-with-high-fructose-fed-mice
#15
Hae Seong Song, Hyun Jung Koo, Bong Kyun Park, Jeong Eun Kwon, Seon-A Jang, Hyun Jin Baek, Se Young Kim, Sung Ryul Lee, Se Chan Kang
CONTEXT: Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L. var. rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity. OBJECTIVES: The synergistic effect of three-herb mixture of C. wilfordii, A. lappa and D. opposita was determined on aortic and liver inflammatory responses. MATERIALS AND METHODS: CWE, ALE and DOE were prepared from the root of C...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29770970/influence-of-internet-dissemination-on-hospital-selection-for-benign-surgical-disease-a-single-center-retrospective-study
#16
Sung Ryul Lee, Bum Hwan Koo, Geon Young Byun, Seung Geun Lee, Myoung Jin Kim, Soo Kyung Hong, Su Yeon Kim, Yu Jin Lee
The Internet is used worldwide, but its effect on hospital selection of minor surgical disease has not hitherto been thoroughly studied. To investigate the effect of the Internet dissemination on hospital selection of minor surgical disease and information affecting selection, we conducted a survey of patients who underwent laparoscopic surgery from January 2016 to April 2017. We analyzed the questionnaire responses of 1916 patients. Over 80% of patients in all groups selected the hospital based on Internet information...
May 17, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29770344/is-delayed-weightbearing-after-matrix-associated-autologous-chondrocyte-implantation-in-the-knee-associated-with-better-outcomes-a-systematic-review-of-randomized-controlled-trials
#17
REVIEW
Matthew J Kraeutler, John W Belk, Trevor J Carver, Eric C McCarty
Background: Proper rehabilitation after matrix-associated autologous chondrocyte implantation (MACI) is essential to restore a patient's normal function without overloading the repair site. Purpose: To evaluate the current literature to assess clinical outcomes of MACI in the knee based on postoperative rehabilitation protocols, namely, the time to return to full weightbearing (WB). Study Design: Systematic review; Level of evidence, 1. Methods: A systematic review was performed to locate studies of level 1 evidence comparing the outcomes of patients who underwent MACI with a 6-week, 8-week, or 10/11-week time period to return to full WB...
May 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770239/comparison-of-marginal-bone-loss-between-internal-and-external-connection-dental-implants-in-posterior-areas-without-periodontal-or-peri-implant-disease
#18
Dae-Hyun Kim, Hyun Ju Kim, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, In-Chul Rhyu
Purpose: The purpose of this retrospective study with 4-12 years of follow-up was to compare the marginal bone loss (MBL) between external-connection (EC) and internal-connection (IC) dental implants in posterior areas without periodontal or peri-implant disease on the adjacent teeth or implants. Additional factors influencing MBL were also evaluated. Methods: This retrospective study was performed using dental records and radiographic data obtained from patients who had undergone dental implant treatment in the posterior area from March 2006 to March 2007...
April 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29769722/bystander-cd8-t-cells-are-abundant-and-phenotypically-distinct-in-human-tumour-infiltrates
#19
Yannick Simoni, Etienne Becht, Michael Fehlings, Chiew Yee Loh, Si-Lin Koo, Karen Wei Weng Teng, Joe Poh Sheng Yeong, Rahul Nahar, Tong Zhang, Hassen Kared, Kaibo Duan, Nicholas Ang, Michael Poidinger, Yin Yeng Lee, Anis Larbi, Alexis J Khng, Emile Tan, Cherylin Fu, Ronnie Mathew, Melissa Teo, Wan Teck Lim, Chee Keong Toh, Boon-Hean Ong, Tina Koh, Axel M Hillmer, Angela Takano, Tony Kiat Hon Lim, Eng Huat Tan, Weiwei Zhai, Daniel S W Tan, Iain Beehuat Tan, Evan W Newell
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that can lead to marked and sustained clinical responses, but only in some patients and cancer types1-4 . Patients and tumours may respond unpredictably to immunotherapy partly owing to heterogeneity of the immune composition and phenotypic profiles of tumour-infiltrating lymphocytes (TILs) within individual tumours and between patients5,6 . Although there is evidence that tumour-mutation-derived neoantigen-specific T cells play a role in tumour control2,4,7-10 , in most cases the antigen specificities of phenotypically diverse tumour-infiltrating T cells are largely unknown...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769611/highly-reproducible-alkali-metal-doping-system-for-organic-crystals-through-enhanced-diffusion-of-alkali-metal-by-secondary-thermal-activation
#20
Jinho Lee, Chibeom Park, Intek Song, Jin Young Koo, Taekyung Yoon, Jun Sung Kim, Hee Cheul Choi
In this paper, we report an efficient alkali metal doping system for organic single crystals. Our system employs an enhanced diffusion method for the introduction of alkali metal into organic single crystals by controlling the sample temperature to induce secondary thermal activation. Using this system, we achieved intercalation of potassium into picene single crystals with closed packed crystal structures. Using optical microscopy and Raman spectroscopy, we confirmed that the resulting samples were uniformly doped and became K2 picene single crystal, while only parts of the crystal are doped and transformed into K2 picene without secondary thermal activation...
May 16, 2018: Scientific Reports
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