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https://www.readbyqxmd.com/read/28651304/rifaximin-and-propranolol-combination-therapy-is-more-effective-than-propranolol-monotherapy-for-the-reduction-of-portal-pressure-an-open-randomized-controlled-pilot-study
#1
Yoo Li Lim, Moon Young Kim, Yoon Ok Jang, Soon Koo Baik, Sang Ok Kwon
Background/Aims: Non-selective beta blockers (NSBBs) are currently the only accepted regimen for preventing portal hypertension (PHT)-related complications. However, the effect of NSBBs is insufficient in many cases. Bacterial translocation (BT) is one of the aggravating factors of PHT in cirrhosis; therefore, selective intestinal decontamination by rifaximin is a possible therapeutic option for improving PHT. We investigated whether the addition of rifaximin to propranolol therapy can improve hepatic venous pressure gradient (HVPG) response...
June 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28647426/age-related-changes-in-structural-connectivity-are-improved-using-subject-specific-thresholding
#2
Corinna M Bauer, Lauren E Zajac, Bang-Bon Koo, Ronald J Killiany, Lotfi B Merabet
BACKGROUND: Deterministic diffusion tractography obtained from high angular resolution diffusion imaging (HARDI) requires user-defined quantitative anisotropy (QA) thresholds. Most studies employ a common threshold across all subjects even though there is a strong degree of individual variation within groups. We sought to explore whether it would be beneficial to use individual thresholds in order to accommodate individual variance. To do this, we conducted two independent experiments...
June 21, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28645333/sac-1004-a-vascular-leakage-blocker-reduces-cerebral-ischemia-reperfusion-injury-by-suppressing-blood-brain-barrier-disruption-and-inflammation
#3
Haiying Zhang, Joon Ha Park, Sony Maharjan, Jeong Ae Park, Kyu-Sung Choi, Hyojin Park, Yoonjeong Jeong, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Jeong Hwi Cho, In-Kyu Lee, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Young-Ger Suh, Moo-Ho Won, Young-Guen Kwon
BACKGROUND: Blood-brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the maintenance of BBB integrity may be a potential target for neuroprotection. Sac-1004, a pseudo-sugar derivative of cholesterol, enhances the endothelial barrier by the stabilization of the cortical actin ring...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28644894/northward-dispersal-of-sea-kraits-laticauda-semifasciata-beyond-their-typical-range
#4
Jaejin Park, Il-Hun Kim, Jonathan J Fong, Kyo-Soung Koo, Woo-Jin Choi, Tein-Shun Tsai, Daesik Park
Marine reptiles are declining globally, and recent climate change may be a contributing factor. The study of sea snakes collected beyond their typical distribution range provides valuable insight on how climate change affects marine reptile populations. Recently, we collected 12 Laticauda semifasciata (11 females, 1 male) from the waters around southern South Korea-an area located outside its typical distribution range (Japan, China including Taiwan, Philippines and Indonesia). We investigated the genetic origin of Korean specimens by analyzing mitochondrial cytochrome b gene (Cytb) sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28644685/application-of-immunohistochemistry-in-the-diagnosis-of-pulmonary-and-pleural-neoplasms
#5
Jennifer S Woo, Opal L Reddy, Matthew Koo, Yan Xiong, Faqian Li, Haodong Xu
CONTEXT: - A vast majority of neoplasms arising from lung or pleura are initially diagnosed based on the histologic evaluation of small transbronchial, endobronchial, or needle core biopsies. Although most diagnoses can be determined by morphology alone, immunohistochemistry can be a valuable diagnostic tool in the workup of problematic cases. OBJECTIVE: - To provide a practical approach in the interpretation and immunohistochemical selection of lung/pleura-based neoplasms obtained from small biopsy samples...
June 23, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28644677/young-athletes-after-anterior-cruciate-ligament-reconstruction-with-single-leg-landing-asymmetries-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-2-years-later
#6
Matthew P Ithurburn, Mark V Paterno, Kevin R Ford, Timothy E Hewett, Laura C Schmitt
BACKGROUND: Previous work shows that young athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate single-leg (SL) landing movement asymmetries at the time of return to sport (RTS); however, the effect of movement asymmetries on longitudinal knee-related function after ACLR has not been examined. Hypothesis/Purpose: The purpose of this study was to examine the effect of SL drop-landing movement symmetry at the time of RTS on knee-related function 2 years later in young athletes after ACLR...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28644550/biphasic-liquid-crystal-and-the-simultaneous-measurement-of-isotropic-and-anisotropic-parameters-by-spatially-resolved-nmr-spectroscopy
#7
Malin Reller, Svenja Wesp, Martin R M Koos, Michael Knut Reggelin, Burkhard Luy
Residual dipolar couplings and other anisotropic NMR parameters are powerful tools for molecular structure elucidation when conventional techniques do not suffice. With current liquid crystalline preparations, it is necessary to prepare two samples to extract isotropic and anisotropic data from spectra and to derive the residual dipolar couplings. Here, we present the preparation, measurement, and interpretation of a novel biphasic liquid crystalline phase where a single sample can be used to generate both isotropic and anisotropic data...
June 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28644025/a-mitochondria-targeted-cryptocyanine-based-photothermogenic-photosensitizer
#8
Hyo Sung Jung, Jae Hong Lee, Kyutae Kim, Seyoung Koo, Peter Verwilst, Jonathan L Sessler, Chulhun Kang, Jong Seung Kim
Cryptocyanine-based probes exhibit highly efficient photothermal conversion and represent a new class of photothermal agents for use in photothermal therapy (PTT). With the thermal susceptibility of mitochondria in mind, we have prepared a mitochondria-targeted, NIR-absorbing cryptocyanine probe (Mito-CCy) and evaluated its photophysical properties, photothermal conversion efficiency, biological compatibility, cytotoxicity, and mitochondrial localization in HeLa cells. Upon subjecting 0.5 mL of a PBS buffer solution (10 mM, pH 7...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28643883/is-ridge-preservation-augmentation-at-periodontally-compromised-extraction-sockets-safe-a-retrospective-study
#9
Jung-Ju Kim, Heithem Ben Amara, Frank Schwarz, Hae-Young Kim, Jung-Won Lee, Ulf Me Wikesjö, Ki-Tae Koo
OBJECTIVES: This study aimed to evaluate the safety of ridge preservation/augmentation procedures when performed at compromised extraction sockets. METHODS: Patients subject to ridge preservation/augmentation at periodontally compromised sockets at Seoul National University Dental Hospital(SNUDH) were evaluated in a chart review. Tooth extractions due to acute infection were not included in our study as chronically formed lesions are the only lesions that can be detected from radiographic images...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28643111/thymic-carcinoma-initially-presented-with-geographic-destruction-of-scapula-in-a-child
#10
Won-Jong Bahk, An-Hi Lee, Eun-Deok Chang, Dong-Wook Min, Yong-Koo Kang
As the conventional histopathologic examination of thymic carcinoma (TC) is nonspecific, immunohistochemical studies along with correlative radiographic investigations are needed for its correct diagnosis. TC commonly occurs in the late 5th to early 6th decades of life but is extremely rare in childhood. It may be incidentally detected from chest radiographs taken as routine or for other reasons. However, most patients present with symptoms such as chest pain, cough, shortness of breath, dysphagia and hoarseness, which are directly attributable to the mediastinal mass...
June 23, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28642855/knowledge-on-osteoporosis-among-nurses
#11
Chan-Ho Park, Young-Kyun Lee, Kyung-Hoi Koo
BACKGROUND: It is crystal clear how important healthcare providers are well-aware of reasonable knowledge on osteoporosis, because they are at the forefront of such management. However, no study has been yet assessed in the knowledge on osteoporosis among healthcare providers particularly in nurse. Therefore, we evaluated the knowledge on osteoporosis of nurses. METHODS: In April 2017, 67 nurses were evaluated using a modified Facts on Osteoporosis Quiz (FOOQ). RESULTS: Although nurses grasped some points of osteoporosis, their knowledge was insufficient concerning effects of weight, physical exercise and calcium intake during adolescence...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642749/rna-seq-reveals-enhanced-sugar-metabolism-in-streptococcus-mutans-co-cultured-with-candida-albicans-within-mixed-species-biofilms
#12
Jinzhi He, Dongyeop Kim, Xuedong Zhou, Sang-Joon Ahn, Robert A Burne, Vincent P Richards, Hyun Koo
Early childhood caries (ECC), which can lead to rampant tooth-decay that is painful and costly to treat, is one of the most prevalent infectious diseases affecting children worldwide. Previous studies support that interactions between Streptococcus mutans and Candida albicans are associated with the pathogenesis of ECC. The presence of Candida enhances S. mutans growth, fitness and accumulation within biofilms in vitro, although the molecular basis for these behaviors is undefined. Using an established co-cultivation biofilm model and RNA-Seq, we investigated how C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28640693/evaluation-of-screening-us-detected-breast-masses-by-combined-use-of-elastography-and-color-doppler-us-with-b-mode-us-in-women-with-dense-breasts-a-multicenter-prospective-study
#13
Su Hyun Lee, Jin Chung, Hye Young Choi, Seon Hyeong Choi, Eun Bi Ryu, Kyung Hee Ko, Hye Ryoung Koo, Jeong Seon Park, Ann Yi, Ji Hyun Youk, Eun Ju Son, A Jung Chu, Jung Min Chang, Nariya Cho, Myoung-Jin Jang, Shin Ho Kook, Eun Suk Cha, Woo Kyung Moon
Purpose To investigate the value of the combined use of elastography and color Doppler ultrasonography (US) with B-mode US for evaluation of screening US-detected breast masses in women with dense breasts. Materials and Methods This prospective, multicenter study included asymptomatic women with dense breasts who were referred for screening US between November 2013 and December 2014. Eligible women had a newly detected breast mass at conventional B-mode US screening, for which elastography and color Doppler US were performed...
June 21, 2017: Radiology
https://www.readbyqxmd.com/read/28639503/markers-of-disease-and-steroid-responsiveness-in-paediatric-idiopathic-nephrotic-syndrome-whole-transcriptome-sequencing-of-peripheral-blood-mononuclear-cells
#14
Hee Gyung Kang, Heewon Seo, Jae Hyun Lim, Jong Il Kim, Kyoung Hee Han, Hye Won Park, Ja Wook Koo, Kee Hyuck Kim, Ju Han Kim, Hae Il Cheong, Il-Soo Ha
Objective To identify markers of disease and steroid responsiveness in paediatric idiopathic nephrotic syndrome. Methods Whole-transcriptome sequencing was performed of peripheral blood mononuclear cells (PBMCs) from patients with NS. Differentially expressed genes (DEGs) were identified in patients with active NS vs those in remission, and those with steroid-sensitive NS (SSNS) vs steroid-resistant NS (SRNS). Results A total of 1065 DEGs were identified in patients with NS ( n = 10) vs those in remission ( n = 9)...
June 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28639043/ultrasonographic-optic-nerve-sheath-diameter-for-predicting-elevated-intracranial-pressure-during-laparoscopic-surgery-a-systematic-review-and-meta-analysis
#15
Eun Jung Kim, Bon-Nyeo Koo, Seung Ho Choi, Kyoungun Park, Min-Soo Kim
BACKGROUND: Laparoscopic surgery involves the creation of a carbon dioxide (CO2) pneumoperitoneum to facilitate a clear surgical view, which may result in an elevated intracranial pressure (ICP). Depending on the surgical area, steep Trendelenburg positioning may be used as well, further increasing the ICP. The objective of this study was to assess the effects of laparoscopic surgery on changes in ICP assessed by ultrasonographic measurement of optic nerve sheath diameter (ONSD), which is a generally accepted simple, reliable, and non-invasive ICP measurement technique...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28637944/service-and-sales-workers-are-they-vulnerable-to-smoking-cessation
#16
Youn-Mo Cho, Jun-Pyo Myong, Hyoung-Ryoul Kim, HyeEun Lee, Jung-Wan Koo
The aim of the present study was to evaluate the association between failed smoking cessation and occupation by age stratification among Korean males and provide quantitative evidence of factors associated with failed smoking cessation. The study comprised 3,127 male workers who had attempted smoking cessation during their life time. Data were obtained from the Korea National Health and Nutrition Examination Survey from 2010 to 2012. Participants were stratified by age into two subgroups comprising a younger group (19-40 years) and an older group (41-60 years)...
June 20, 2017: Industrial Health
https://www.readbyqxmd.com/read/28637447/differential-gene-expression-at-different-stages-of-mesocarp-development-in-high-and-low-yielding-oil-palm
#17
Yick Ching Wong, Huey Fang Teh, Katharina Mebus, Tony Eng Keong Ooi, Qi Bin Kwong, Ka Loo Koo, Chuang Kee Ong, Sean Mayes, Fook Tim Chew, David R Appleton, Harikrishna Kulaveerasingam
BACKGROUND: The oil yield trait of oil palm is expected to involve multiple genes, environmental influences and interactions. Many of the underlying mechanisms that contribute to oil yield are still poorly understood. In this study, we used a microarray approach to study the gene expression profiles of mesocarp tissue at different developmental stages, comparing genetically related high- and low- oil yielding palms to identify genes that contributed to the higher oil-yielding palm and might contribute to the wider genetic improvement of oil palm breeding populations...
June 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28634350/a-subset-of-cerebrovascular-pericytes-originates-from-mature-macrophages-in-the-very-early-phase-of-vascular-development-in-cns
#18
Seiji Yamamoto, Masashi Muramatsu, Erika Azuma, Masashi Ikutani, Yoshinori Nagai, Hiroshi Sagara, Bon-Nyeo Koo, Satomi Kita, Erin O'Donnell, Tsuyoshi Osawa, Hiroyuki Takahashi, Ken-Ichi Takano, Mitsuko Dohmoto, Michiya Sugimori, Isao Usui, Yasuhide Watanabe, Noboru Hatakeyama, Takahiro Iwamoto, Issei Komuro, Kiyoshi Takatsu, Kazuyuki Tobe, Shumpei Niida, Naoyuki Matsuda, Masabumi Shibuya, Masakiyo Sasahara
Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of cerebrovascular pericytes during neurogenesis. In the CNS of embryonic day 10.5 mouse embryos, CD31(+)F4/80(+) hematopoietic lineage cells were observed in the avascular region around the dorsal midline of the developing midbrain...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633724/change-in-end-expiratory-lung-volume-during-sleep-in-patients-at-risk-for-obstructive-sleep-apnea
#19
Patrick Koo, Eric J Gartman, Jigme M Sethi, Eyad Kawar, F Dennis McCool
STUDY OBJECTIVES: As lung volume decreases radial traction on the upper airway is reduced, making it more collapsible. The purpose of this study was to measure change in end-expiratory lung volume (EELV) following sleep onset and to evaluate the relationship between change in EELV and sleep-disordered breathing. METHODS: Twenty subjects underwent overnight polysomnography, of whom 14 (70%) had obstructive sleep apnea (OSA). Change in EELV was measured throughout the night using magnetometry...
June 16, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28633525/use-of-dimethyl-pimelimidate-with-microfluidic-system-for-nucleic-acids-extraction-without-electricity
#20
Choong Eun Jin, Tae Yoon Lee, Bonhan Koo, Kyung-Chul Choi, Suhwan Chang, Se Yoon Park, Ji Yeun Kim, Sung-Han Kim, Yong Shin
The isolation of nucleic acids in the lab on a chip is crucial to achieve the maximal effectiveness of point-of-care testing for detection in clinical applications. Here, we report on the use of a simple and versatile single-channel microfluidic platform that combines dimethyl pimelimidate (DMP) for nucleic acids (both RNA and DNA) extraction without electricity using thin films system. The system is based on the adaption of DMP into non-chaotropic-based nucleic acids and the capture of reagents into a low-cost thin film platform for use as a microfluidic total analysis system, which can be utilized for sample processing in clinical diagnostics...
June 21, 2017: Analytical Chemistry
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