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Zhao Huajie
OBJECTIVE: To investigate the influence of resveratrol (RES) on myocardial energy metabolism in sepsis rats and its mechanism. METHODS: Twenty Sprague-Dawley (SD) rats were divided into four groups according to the random number table, 5 rats in each group. The sepsis model was reproduced by intraperitoneal injection of lipopolysaccharide (LPS) 10 mg/kg, and the rats in sham group were injected intraperitoneally with the same amount of saline. The rats in RES treatment group (RES group) were injected RES 8 mg/kg 10 minutes before LPS injection, and those in RES combined with the silent information regulator 1 (sirti) inhibitor group (RES + sirtinol group) were injected sirtinol 1 mg/kg followed by RES 8 mg/kg 10 minutes before LPS injection...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Maria Anete Lallo, Lidiana Flora Vidoto Da Costa, Anuska Marcelino Alvares-Saraiva, Paulo Ricardo Dell'Armelina Rocha, Diva Denelle Spadacci-Morena, Fabiana Toshie de Camargo Konno, Ivana Barbosa Suffredini
Microsporidia are obligate intracellular mitochondria-lacking pathogens that rely on host cells to grow and multiply. Microsporidia, currently classified as fungi, are ubiquitous in nature and are found worldwide. They infect a large number of mammals and are recognized as opportunistic infection agents in HIV-AIDS patients. Its importance for veterinary medicine has been unveiled in recent years through the description of clinical and subclinical forms of infection in domestic and wild animals. Domestic and wild birds may be infected by the same human microsporidia, reinforcing their zoonotic potential...
February 2016: Journal of Veterinary Medical Science
Quanxiu Li, Chuangye Yan, Huisha Xu, Zheng Wang, Jiafu Long, Wenqi Li, Jianping Wu, Ping Yin, Nieng Yan
Pentatricopeptide repeat (PPR) proteins, particularly abundant in plastids and mitochrondria of angiosperms, include a large number of sequence-specific RNA binding proteins that are involved in diverse aspects of organelle RNA metabolisms. PPR proteins contain multiple tandom repeats, and each repeat can specifically recognize a RNA base through residues 2, 5, and 35 in a modular fashion. The crystal structure of PPR10 from maize chloroplast exhibits dimeric existence both in the absence and presence of the 18-nucleotide psaJ RNA element...
November 7, 2014: Journal of Biological Chemistry
Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
BACKGROUND: Exposure to high concentrations of oxygen radicals, the lack of nucleus and mitochrondria, inability to synthesise new protein and degradation of detoxifying enzymes makes red blood cells (RBCs) uniquely vulnerable to oxidative stress. This review summarizes the changes in biochemical parameters that primarily contribute to alterations in red blood cells during oxidative stress. METHODS: PubMed, Science Direct and Springer online databases and updates from the Indian Council of Medical Research (ICMR)...
June 2011: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
James W Simpkins, Kun Don Yi, Shao-Hua Yang, James A Dykens
Mitochondria have become a primary focus in our search not only for the mechanism(s) of neuronal death but also for neuroprotective drugs and therapies that can delay or prevent Alzheimer's disease and other chronic neurodegenerative conditions. This is because mitochrondria play a central role in regulating viability and death of neurons, and mitochondrial dysfunction has been shown to contribute to neuronal death seen in neurodegenerative diseases. In this article, we review the evidence for the role of mitochondria in cell death and neurodegeneration and provide evidence that estrogens have multiple effects on mitochondria that enhance or preserve mitochondrial function during pathologic circumstances such as excitotoxicity, oxidative stress, and others...
October 2010: Biochimica et Biophysica Acta
A M Breslau, T J Hensley, J O Erickson
Spherules of C. immitis have been grown in vitro in modified Roessler's medium under CO(2) tension and continuous cultures now maintained for over 18 months. Transformation of hyphae and development of the spherule form have been studied by thin section electron microscopy. Cells of organisms in the hyphal stage have thin (ca. 50 mmicro), apparently structureless walls and a cytoplasmic membrane. Many nuclei, elongated mitochrondria with both transverse and longitudinal cristae, and lipid particles are present...
March 1, 1961: Journal of Biophysical and Biochemical Cytology
Dan-Li Yang, Hai-Gang Zhang, Ya-Li Xu, Yun-Hua Gao, Xiao-Jiao Yang, Xue-Qin Hao, Xiao-Hui Li
1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the protective effects of RSV against monocrotaline (MCT)-induced right ventricular (RV) hypertrophy in rats. 2. Male Sprague-Dawley rats were given a single injection of MCT (50 mg/kg, s.c.) and were then treated with either vehicle (normal saline) or RSV (10 and 30 mg/kg, i...
February 2010: Clinical and Experimental Pharmacology & Physiology
O Paciello, M P Pasolini, L Navas, V Russo, S Papparella
Central core disease is a nonprogressive or slowly progressive congenital myopathy with a variable degree of hypotonia and axial and proximal muscle weakness that is histologically characterized by areas devoid of oxidative enzyme activity, resulting from an absence or low numbers of mitochondria in these regions (central core). A 10-month-old, male, pony foal was examined because of stiff gait, marked contractures of the distal portion of the limbs, flexion deformities of the hooves, and moderate hypotonia that had been present from birth...
July 2006: Veterinary Pathology
Z Liu, W R Bushnell, R Brambl
Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in mitochondria within 15 to 30 minutes without appreciable staining of other protoplasmic constituents. The number, shape, and movement of the fluorescent mitochondria could be seen readily, and the fluorescence intensity of the mitochondria could be monitored with a microscope photometer. Fluorescence was eliminated in 1 to 5 minutes by the protonophore carbonyl cyanide m-chlorophenylhydrazone (CCCP) indicating that maintenance of dye concentration was dependent on the inside-negative transmembrane potential maintained by functional mitochondria...
August 1987: Plant Physiology
N G Grant, M H Hommersand
The respiration and cytochrome properties of "glucose-bleached" Chlorella protothecoides Krüger, Indiana strain 25, were studied. This organism, when grown heterotrophically with high glucose and a low organic nitrogen source, has no chlorophyll, little carotenoid, and diminished chloroplast structure-factors which make it suitable for respiration studies.Whole cell endogenous oxygen uptake rates are either stimulated or only slightly inhibited by cyanide, azide, CO, and antimycin. When these inhibitors are used with m-chlorobenz-hydroxamic acid (mCLAM), an inhibitor of higher plant mitochondrial alternate oxidase, O(2) uptake is inhibited...
July 1974: Plant Physiology
H W Zhao, S Y Hu, M W Barger, J K H Ma, V Castranova, J Y C Ma
Tumor necrosis factor-alpha (TNF-a) is produced by alveolar macrophages (AM) in response to bleomycin (BLM) exposure. This cytokine has been linked to BLM-induced pulmonary inflammation, an early drug effect, and to lung fibrosis, the ultimate toxic effect of BLM. The present study was carried out to study the time dependence of apoptotic signaling pathways and the potential roles of TNF receptors in BLM-induced AM apoptosis. Male Sprague-Dawley rats were exposed to saline or BLM (1 mg/kg) by intratracheal instillation...
September 10, 2004: Journal of Toxicology and Environmental Health. Part A
R Perasso, J J Curgy, N Stelly, J Andre
The effects of chloramphenicol (CAP) on mitochondrial respiratory activity in the wild strain (ST) and in a cytoplasmic CAP-resistant mutant (STR1) of Tetrahymena pyriformis were studied by determining oxygen consumption, by spectrophotometry, and by cytochemistry. In the absence of CAP both strains had the same respiration capacity, and the low-temperature spectra of their isolated mitochondria were similar. Furthermore, the mitochondria of both strains showed a positive reaction with diaminobenzidine, denoting a similar cytochrome oxidase activity...
June 1982: Molecular and Cellular Biology
No abstract text is available yet for this article.
June 21, 1964: Doklady Akademii Nauk SSSR
No abstract text is available yet for this article.
1963: Acta Biologica et Medica Germanica
No abstract text is available yet for this article.
March 1963: Farmakologiia i Toksikologiia
No abstract text is available yet for this article.
November 1957: Biochimica et Biophysica Acta
1. In the present study a correlation has been sought between aging, flight muscle mitochrondria (sarcosomes), cytochrome c, and flight ability in the blowfly, Phormia regina. 2. During the 1st week of adult life, individual sarcosomes increase in mass from 2.7 x 10(-7) microg. dry weight at the time of emergence, to 8.5 x 10(-7) microg. by the 7th day. During this period of growth, the number of sarcosomes per fly (6.7 x 10(8)) remains constant. When mature, the sarcosomes account for 32.6 per cent of the total muscle dry weight, or close to 40 per cent on a wet weight basis...
March 20, 1956: Journal of General Physiology
No abstract text is available yet for this article.
June 1953: Journal of Bacteriology
Jin-Yi Jiang, Carmen K M Cheung, Yifang Wang, Benjamin K Tsang
Mammalian ovarian follicular development and atresia is closely regulated by the cross talk of cell death and cell survival signals, which include endocrine hormones (gonadotropins) and intra-ovarian regulators (gonadal steroids, cytokines and growth factors). The fate of the follicle is dependent on a delicate balance in the expression and actions of factors promoting follicular cell proliferation, growth and differentiation and of those inducing programmed cell death (apoptosis). As an important endocrine hormone, FSH binds to its granulosa cell receptors and promotes ovarian follicle survival and growth not only by stimulating proliferation and estradiol secretion of these cells, but also inhibiting the apoptosis by up-regulating the expression of intracellular anti-apoptotic proteins, such as XIAP and FLIP...
January 1, 2003: Frontiers in Bioscience: a Journal and Virtual Library
Siu Sylvia Lee, Raymond Y N Lee, Andrew G Fraser, Ravi S Kamath, Julie Ahringer, Gary Ruvkun
We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan. We found that genes important for mitochondrial function stand out as a principal group of genes affecting C. elegans lifespan. A classical genetic screen identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was associated with longer-lifespan. The long-lived worms with impaired mitochondria had lower ATP content and oxygen consumption, but differential responses to free-radical and other stresses...
January 2003: Nature Genetics
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