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https://www.readbyqxmd.com/read/28344607/locally-advanced-adenocarcinoma-of-the-cervix-on-uterus-didelphys-a-case-report
#1
Abel Cordoba, Alexandre Escande, Pauline Comte, Ingrid Fumagalli, Lucie Bresson, Ndaye Mubiayi, Eric Lartigau
In November 2013, a woman with Herlyn-Werner-Wunderlich (HWW) syndrome was diagnosed with a locally advanced left cervical adenocarcinoma. The patient's malformation consisted of two uteri with two cervixes, a obstructed vagina, and a left renal agenesis. Classification FIGO: stage IIIa because of infiltration of the inferior third of the vagina wall. Locoregional management comprised an infrarenal lateral aortic lymphadenectomy followed by concomitant radio-chemotherapy to the pelvic (inguinal, pelvic, and infrarenal para aortic nodes) volumes...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28340235/polymerase-chain-reaction-human-papillomavirus-hpv-detection-and-hpv-genotyping-in-invasive-cervical-cancers-with-prior-negative-hc2-test-results
#2
Xiang Tao, Baowen Zheng, Fufen Yin, Zhengyu Zeng, Zaibo Li, Christopher C Griffith, Bing Luo, Xiangdong Ding, Xianrong Zhou, Chengquan Zhao
Objectives: Recently, three large Chinese cohort studies showed that 7.5% to 15.5% of patients with cervical carcinoma had negative high-risk human papillomavirus (hrHPV) test results on prior cytology specimens. These studies raise the question as to whether these negative hrHPV results represent truly hrHPV-negative carcinomas or false-negative hrHPV test results due to limitations in the testing of cytology specimens. This is increasingly an important question with increasing push to use hrHPV testing alone to screen for cervical cancer...
March 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28331901/isolated-port-site-recurrence-of-node-negative-clinical-stage-ib1-cervical-adenocarcinoma
#3
Uma Deshmukh, Molly McAdow, Jonathan Black, Pei Hui, Masoud Azodi
INTRODUCTION: Port site metastasis after laparoscopic surgery for cervical cancer is a rare phenomenon. METHODS: We present a case report of isolated port site recurrence 4 years following laparoscopic surgery in a patient with node-negative, clinical stage IB1 cervical adenocarcinoma. RESULTS: A 44 year-old woman presented with a necrotic cervical lesion. A biopsy of the mass revealed invasive endocervical adenocarcinoma. She underwent a robotic-assisted radical hysterectomy, bilateral salpingectomy, and pelvic lymph node dissection with bilateral oophoropexy...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28331341/investigating-the-expression-effect-and-tumorigenic-pathway-of-padi2-in-tumors
#4
Wei Guo, Yabing Zheng, Bing Xu, Fang Ma, Chang Li, Xiaoqian Zhang, Yao Wang, Xiaotian Chang
BACKGROUND: Peptidylarginine deiminase (PAD) catalyzes the conversion of arginine residues to citrulline residues, termed citrullination. Recent studies have suggested that PAD isoform 2 (PADI2) plays an important role in tumors, although its tumorigenic effect and mechanism are largely unknown. MATERIALS AND METHODS: Immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) were used to investigate the expression level of PADI2 in various tumor tissues and patient blood samples, respectively...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28326512/tissue-expression-of-human-epididymal-secretory-protein-4-may-be-useful-in-the-differential-diagnosis-of-uterine-cervical-tumors
#5
Gulden Diniz, Tugba Karadeniz, Sevil Sayhan, Talya Akata, Fatma Aydiner, Duygu Ayaz, Dudu Solakoglu Kahraman, Tulay Akman
OBJECTIVES: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors. MATERIAL AND METHODS: This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28302659/clear-cell-adenocarcinoma-of-cervix-in-1-year-old-girl-without-in-utero-exposure-to-diethylstilbestrol-an-uncommon-tumour-at-an-uncommon-age-and-site
#6
Aditi Arora, Anurag Rastogi, Azfar Neyaz, Nuzhat Husain
Adenocarcinoma of cervix constitutes about 10-15% cases of carcinoma cervix. Clear cell variant is even a rarer variant of adenocarcinoma. It rarely occurs in the paediatric age group and a known risk factor is in utero exposure to diethylstilbestrol (DES). We report here a case of primary cervical tumour in a 1-year-old girl, which was initially suspected to be an embryonal rhabdomyosarcoma botryoides. Histopathology with immunohistochemical analysis revealed clear cell adenocarcinoma. There was no maternal history of DES intake during pregnancy...
March 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28298953/cellular-preoxygenation-partially-attenuates-the-antitumoral-effect-of-cisplatin-despite-highly-protective-effects-on-renal-epithelial-cells
#7
Bahram Rasoulian, Ayat Kaeidi, Maryam Rezaei, Zahra Hajializadeh
Our previous in vitro studies demonstrated that oxygen pretreatment significantly protects human embryonic renal tubular cell against acute cisplatin- (CP-) induced cytotoxicity. The present study was designed to investigate whether this protective effect is associated with decreasing therapeutic effects of cisplatin on malignant cells. For this purpose, cultured human embryonic kidney epithelial-like (AD293), cervical carcinoma epithelial-like (Hela), and ovarian adenocarcinoma epithelial-like (OVCAR-3) cells were subjected to either 2-hour pretreatment with oxygen (≥90%) or normal air and then to a previously determined 50% lethal dose of cisplatin for 24 hours...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28287429/d-amino-acid-position-influences-the-anticancer-activity-of-galaxamide-analogs-an-apoptotic-mechanism-study
#8
Defa Bai, Siming Yu, Shenghui Zhong, Bingxin Zhao, Shaoling Qiu, Jianwei Chen, Jignesh Lunagariya, Xiaojian Liao, Shihai Xu
Galaxamide, an extract from Galaxaura filamentosa, is a cyclic pentapeptide containing five l-leucines. Due to the particular cyclic structure and the excellent anticancer activity, synthesis of Galaxamide and its analogs and their subsequent bio-applications have attracted great attention. In the present work, we synthesized six Galaxamide analogs by replacing one of the l-leucines with phenylalanine and varying the d-amino acid position. The anticancer effect of the synthesized Galaxamide analogs was tested against four in vitro human cancer cell lines, human hepatocellular cells (HepG₂), human breast cancer cell (MCF-7), human breast adenocarcinoma cells (MDA-MB-435) and a human cervical carcinoma cell line (Hela)...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28277315/clear-cell-carcinoma-of-the-uterine-cervix-presented-as-submucosal-tumor-arising-from-a-background-of-cervical-endometriosis
#9
Mariko Hashiguchi, Keita Kai, Satoshi Nishiyama, Yoshifumi Nakao, Masatoshi Yokoyama, Shinichi Aishima
Clear cell carcinoma (CCC) of the uterine cervix without prenatal diethylstilbestrol exposure is rare, and its etiology is unclear. We present a case of cervical CCC presenting as a submucosal tumor, which strongly suggests an association between cervical endometriosis and cervical CCC. A 56-year-old postmenopausal Japanese woman visited a gynecologic clinic with a complaint of watery vaginal discharge. A few atypical cells suggesting adenocarcinoma were detected in a cervical cytologic specimen. Magnetic resonance imaging revealed a cystic lesion with a solid component at the uterine cervix...
March 8, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28275694/clear-cell-adenocarcinoma-of-the-cervix-in-second-generation-young-women-who-are-without-maternal-exposure-to-diethylstilbestrol-a-case-report
#10
Tanitra Tantitamit, Suttha Hamontri, Likit Rangsiratanakul
Clear cell adenocarcinoma of the cervix (CCAC) is a rare type of gynecological cancer. The risk factors and pathogenesis have yet to be clearly determined. This is a case report of a 19-year-old woman, who was never exposed to DES from her mother, who had gone for an examination for vaginal bleeding. A polypoid mass measured at 3 cm presenting in her cervix was discovered. Histological diagnosis following cervical biopsy proved the tumor to be a clear cell carcinoma. The patient was then referred to our hospital...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28273493/influence-of-dynamic-flow-environment-on-nanoparticle-protein-corona-from-protein-patterns-to-uptake-in-cancer-cells
#11
Sara Palchetti, Daniela Pozzi, Anna Laura Capriotti, Giorgia La Barbera, Riccardo Zenezini Chiozzi, Luca Digiacomo, Giovanna Peruzzi, Giulio Caracciolo, Aldo Laganà
The fast growing use of nanoparticles (NPs) in biotechnology and biomedicine raises concerns about human health and the environment. When introduced in physiological milieus, NPs adsorb biomolecules (especially proteins) forming the so-called protein corona (PC). As it is the PC that mostly interacts with biological systems, it represents a major element of the NPs' biological identity with impact on nanotoxicology, nanosafety and targeted delivery of nanomedicines. To date, NP-protein interactions have been largely investigated in vitro, but this condition is far from mimicking the dynamic nature of physiological environments...
February 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28272660/prominent-signet-ring-cell-morphology-in-a-pulmonary-squamous-cell-carcinoma
#12
Nuri Yiğit, Ertuğrul Çelik, İbrahim Yavan
In daily practice, signet ring cell morphology immediately brings to the mind the possibility of an adenocarcinoma at first glance. The signet ring cell appearance has been described and is well-known in a wide variety of some other neoplasms as well. Surprisingly however, neoplastic cells having the same morphology can unexpectedly be encountered in not previously well-documented tumors. Here, we present an 85-year-old man diagnosed with primary pulmonary squamous cell carcinoma and a large signet ring cell population...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28267911/-360-degrees-instrumentation-for-cervical-instability-due-to-metastatic-bone-disease-case-report
#13
J E Vargas-Jasso, M A Clara-Altamirano, G Reyes-Soto, M Cuéllar-Hubbe, J A Mejía-Pérez
INTRODUCTION: The spine is the most common site for bone metastases; being the breast, prostate and lung cancer which have most affected. The thoracic spine is involved in 70% of cases, followed by the lumbar and cervical region. MATERIAL AND METHODS: This is a 59 years old female diagnosed with breast adenocarcinoma and metastatic bone disease in cervical spine C2, C3 level and instability of that segment because of a compression fracture of C3 greater than 80% without invasion of the spinal canal, she begins with paresthesias of upper limbs...
July 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28264203/underdiagnosis-of-cervical-intraepithelial-neoplasia-cin-2-or-worse-lesion-in-women-with-a-previous-colposcopy-guided-biopsy-showing-cin-1
#14
Carlos André Scheler de Souza, Michelle Garcia Discacciati, Maria Gabriela d'Otavianno, Silvia Maria Bergo, Markus Traue, Liliana Aparecida Lucci de Angelo Andrade, Luiz Carlos Zeferino
Objective Expectant follow-up for biopsy-proven cervical intraepithelial neoplasia (CIN) 1 is the current recommendation for the management of this lesion. Nevertheless, the performance of the biopsy guided by colposcopy might not be optimal. Therefore, this study aimed to calculate the rate of underdiagnoses of more severe lesions in women with CIN 1 diagnosis and to evaluate whether age, lesion extent and biopsy site are factors associated with diagnostic failure. Methods Eighty women with a diagnosis of CIN 1 obtained by colposcopy-guided biopsy were selected for this study...
March 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28255734/robot-assisted-laparoscopic-transperitoneal-infrarenal-lymphadenectomy-in-patients-with-locally-advanced-cervical-cancer-by-single-docking-do-we-need-a-backup-procedure
#15
Fatih Gucer, Selim Misirlioglu, Nuri Ceydeli, Cagatay Taskiran
To present our initial experience on the feasibility of robotic transperitoneal para-aortic lymphadenectomy up to left renal vein via single docking approach by high port insertion technique followed by left shoulder docking as a rescue backup procedure in surgically obstructed patients undergoing surgical staging because of locally advanced cervical cancer (LACC). Prospective observational preliminary study. Canadian Task Force classification II-3. Tertiary-care academic affiliated private hospital. Ten patients with LACC who underwent robotic transperitoneal infrarenal para-aortic lymphadenectomy between January 2012 and December 2014...
March 2, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28255362/her-family-receptors-are-important-theranostic-biomarkers-for-cervical-cancer-blocking-glucose-metabolism-enhances-the-therapeutic-effect-of-her-inhibitors
#16
Olga Martinho, Renato Silva-Oliveira, Fernanda P Cury, Ana Martins Barbosa, Sara Granja, Adriane Feijó Evangelista, Fábio Marques, Vera Miranda-Gonçalves, Diana Cardoso-Carneiro, Flávia E de Paula, Maicon Zanon, Cristovam Scapulatempo-Neto, Marise A R Moreira, Fátima Baltazar, Adhemar Longatto-Filho, Rui Manuel Reis
Persistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic marker for these patients. By using in vitro and in vivo approaches, we provided evidence that HER inhibitors, allitinib and lapatinib, were effective in reducing cervical cancer aggressiveness...
2017: Theranostics
https://www.readbyqxmd.com/read/28254283/graphene-oxide-as-a-nanocarrier-for-controlled-release-and-targeted-delivery-of-an-anticancer-active-agent-chlorogenic-acid
#17
Farahnaz Barahuie, Bullo Saifullah, Dena Dorniani, Sharida Fakurazi, Govindarajan Karthivashan, Mohd Zobir Hussein, Fawzi M Elfghi
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorogenic acid-graphene oxide nanocomposite (CAGO) were characterized using Fourier transform infrared (FTIR) spectroscopy, thermogravimetry and differential thermogravimetry analysis, Raman spectroscopy, powder X-ray diffraction (PXRD), UV-vis spectroscopy and high resolution transmission electron microscopy (HRTEM) techniques...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28249781/assessment-of-anti-cancerous-potential-of-6-gingerol-tongling-white-ginger-and-its-synergy-with-drugs-on-human-cervical-adenocarcinoma-cells
#18
Fang Zhang, Jian-Guo Zhang, Jie Qu, Qi Zhang, Chandan Prasad, Zhao-Jun Wei
The anti-cancerous activity of 6-gingerol extracted from Tongling White Ginger was investigated. 6-Gingerol inhibited the growth of HeLa cells with IC50 (96.32 μM) and IC80 (133.01 μM) and led to morphological changes, induced the cell cycle arrest in G0/G1-phase and ultimately resulted into apoptosis. Among cell cycle-related genes and proteins, the expression of cyclin (A, D1, E1) reduced, while of CDK-1, p21 and p27 showed slight decrease, except cyclin B1 and E1 (protein). Western blotting reported the induction of apoptosis with an increased Bax/Bcl-2 ratio, release of cytochrome c, cleavage of caspase-3, -8, -9 and PRPP in treated cells...
February 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28249711/comparison-of-ffpe-histological-versus-lbp-cytological-samples-for-hpv-detection-and-typing-in-cervical-cancer
#19
Geehyuk Kim, Hyemi Cho, Dongsup Lee, Sunyoung Park, Jiyoung Lee, Hye-Young Wang, Sunghyun Kim, Kwang Hwa Park, Hyeyoung Lee
Human papillomavirus (HPV) infection is closely associated with cervical cancer. This study analyzed HPV genotype prevalence in 75 cases of formalin-fixed paraffin embedded (FFPE) tissue samples from patients diagnosed with cervical cancer. Genotype prevalence was assessed using Reverse Blot Assay (REBA) and quantitative polymerase chain reaction (qPCR), which target the HPV L1 and HPV E6/E7 genes, respectively. HPV DNA chip tests were also performed using liquid based preparation (LBP) cytological samples from the same patients who provided the FFPE histological samples...
February 27, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28245508/immunohistochemical-expression-of-the-tumor-suppressor-protein-p16ink4a-in-cervical-adenocarcinoma
#20
José Eleutério, Thiago Silva Lima, Maria do Perpétuo Socorro Cunha, Diane Isabelle Magno Cavalcante, Angélica Maria Holanda Silva
Objective To evaluate the diagnostic utility of the p16(ink4a) protein expression as a marker for adenocarcinoma of the cervix. Methods In a cross-sectional study, p16(ink4a) expression was evaluated in 30 cervical biopsies from patients diagnosed with invasive adenocarcinoma from 2 reference clinics in Brazil, and compared with 18 biopsies of endocervical polyps (control cases). The performance of the tests for p16(ink4a) was evaluated using a conventional contingency table, and the Kappa (κ) index was used to evaluate the agreement of the marker with the tissue diagnosis...
January 2017: Revista Brasileira de Ginecologia e Obstetrícia
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