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cutaneous B cell lymphoma

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https://www.readbyqxmd.com/read/29661716/small-cell-lymphocytic-variant-of-marginal-zone-lymphoma-a-distinct-form-of-marginal-zone-lymphoma-derived-from-na%C3%A3-ve-b-cells-as-a-cutaneous-counterpart-to-the-na%C3%A3-ve-marginal-zone-lymphoma-of-splenic-origin
#1
REVIEW
Cynthia M Magro, Luke C Olson
Primary cutaneous marginal zone lymphoma most commonly represents an indolent form of cutaneous B cell lymphoma. However, epidermotropic marginal zone lymphoma, blastic marginal zone lymphoma and B cell dominant variants without isotype switching can be associated with extracutaneous dissemination. The presumptive cell of origin is a post germinal center B cell with plasmacytic features. In the extracutaneous setting, however, a naïve B cell origin has been proposed for a subset of marginal zone lymphomas, notably splenic marginal zone lymphoma...
February 21, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661476/cutaneous-presentation-of-adult-t-cell-leukemia-lymphoma-atll-single-center-study-on-37-patients-in-metropolitan-france-between-1996-and-2016
#2
C Hurabielle, M Battistella, C Ram-Wolff, C Fite, V Meignin, J Rivet, M-D Vignon-Pennamen, T de Risi-Pugliese, E Raffoux, B Arnulf, E Oksenhendler, F Sicre de Fontbrune, R Peffault de Latour, G Socié, J-D Bouaziz, C Lebbé, A Bensussan, M Bagot
INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection. AIM: To describe skin lesions in ATLL. METHODS: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France). RESULTS: Thirty-seven ATLL patients were included. Fifteen patients (41%) had a cutaneous localization of the disease, which was present from the beginning of the disease for two thirds of them...
April 13, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29659938/mutual-risks-of-cutaneous-melanoma-and-specific-lymphoid-neoplasms-second-cancer-occurrence-and-survival
#3
Megan M Herr, Sara J Schonfeld, Graça M Dores, Diana R Withrow, Margaret A Tucker, Rochelle E Curtis, Lindsay M Morton
Background: It is unclear whether the established association between cutaneous melanoma (CM) and lymphoid neoplasms (LNs) differs across LN subtypes. This study quantifies risk for developing CM after specific LNs and, conversely, for developing specific LNs after CM, as well as assessing clinical impact. Methods: We identified a cohort of Caucasian adults (age 20-83 years) initially diagnosed with CM or LN, as reported to 17 US population-based cancer registries, 2000-2014...
April 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29618683/-malt-lymphoma-with-t-x-14-p11-2-q32-developing-during-the-course-of-cutaneous-leukocytoclastic-angitis
#4
Yu Uemura, Hirotaka Sakai, Yusuke Saiki, Akiko Uchida, Kazuyuki Sato, Yuka Tsuruoka, Satoshi Yokoi, Yuji Nishio, Manabu Matsunawa, Yoshinori Suzuki, Yasushi Isobe, Masayuki Kato, Naoto Tomita, Yasuyuki Inoue, Ikuo Miura
A 73-year-old man with left parotid gland swelling over 2 months was referred to our hospital in March 201X. Purpura on the lower legs had been recurrent for >20 years. Biopsy of the parotid gland demonstrated diffuse infiltration of abnormal lymphocytes that were negative for CD10 and positive for CD19, CD20, and κ-chain. The Ki-67 positivity was <10%; lymphoepithelial lesions were observed. The patient was diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29596904/a-single-arm-phase-ii-trial-of-lenalidomide-in-relapsing-or-refractory-primary-cutaneous-large-b-cell-lymphoma-leg-type
#5
Marie Beylot-Barry, Diane Mermin, Aline Maillard, Reda Bouabdallah, Nathalie Bonnet, Anne-Bénédicte Duval-Modeste, Laurent Mortier, Saskia Ingen-Housz-Oro, Caroline Ram-Wolff, Stéphane Barete, Stéphane Dalle, Eve Maubec, Gaelle Quereux, Isabelle Templier, Martine Bagot, Florent Grange, Pascal Joly, Béatrice Vergier, Pierre-Julien Vially, Audrey Gros, Anne Pham-Ledard, Eric Frison, Jean-Philippe Merlio
While the combination of rituximab and polychemotherapy has improved prognosis of primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT), advanced age of patients limits therapeutic options in relapsing/refractory cases. A multicenter single-arm phase II trial was conducted to assess benefit and safety of lenalidomide in refractory/relapsing PCDLBCL, LT. Primary endpoint was the 6-month overall response rate (ORR). Secondary endpoints were 12-month ORR, overall and specific survival, duration of response, progression-free survival (PFS), safety and identification of prognostic factors...
March 26, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29581544/double-hit-or-dual-expression-of-myc-and-bcl2-in-primary-cutaneous-large-b-cell-lymphomas
#6
Sarah Menguy, Eric Frison, Martina Prochazkova-Carlotti, Stephane Dalle, Olivier Dereure, Serge Boulinguez, Sophie Dalac, Laurent Machet, Caroline Ram-Wolff, Laurence Verneuil, Audrey Gros, Béatrice Vergier, Marie Beylot-Barry, Jean-Philippe Merlio, Anne Pham-Ledard
In nodal diffuse large B-cell lymphoma, the search for double-hit with MYC and BCL2 and/or BCL6 rearrangements or for dual expression of BCL2 and MYC defines subgroups of patients with altered prognosis that has not been evaluated in primary cutaneous large B-cell lymphoma. Our objectives were to assess the double-hit and dual expressor status in a cohort of 44 patients with primary cutaneous large B-cell lymphoma according to the histological subtype and to evaluate their prognosis relevance. The 44 cases defined by the presence of more than 80% of large B-cells in the dermis corresponded to 21 primary cutaneous follicle centre lymphoma with large cell morphology and 23 primary cutaneous diffuse large B-cell lymphoma, leg type...
March 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29578630/outcomes-of-radiation-therapy-of-indolent-cutaneous-b-cell-lymphomas-and-literature-review
#7
Marie-Léa Gauci, Laurent Quero, Caroline Ram-Wolff, Sophie Guillerm, Besma M'Barek, Céleste Lebbé, Martine Bagot, Christophe Hennequin
BACKGROUND: Primary cutaneous B cell lymphomas represent approximately 25% of primary cutaneous lymphomas. Follicular center cell lymphomas (PCFCL) and marginal zone lymphomas (PCMZL) are the two histological subtypes that present an indolent evolution. Radiotherapy is one of the recommended treatment options with few series reported. OBJECTIVE: This study aimed to evaluate radiotherapy outcomes in term of overall survival (OS) and disease-free survival (DFS) for patients suffering from a PCMZL or PCFCL, to search for predictive factors of recurrence, and to evaluate chronic and aesthetics adverse events and patient's satisfaction...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29568990/necrobiotic-xanthogranuloma-a-30-year-single-center-experience
#8
Talal Hilal, David J DiCaudo, Suzanne M Connolly, Craig B Reeder
To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, associated disorders, therapy, and response to therapy were extracted. Nineteen patients were identified. Mean age was 54 years (range, 17-84) with equal gender distribution. Median follow-up was 5...
March 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29552123/expression-profiling-analysis-of-autophagy-related-genes-in-perineural-invasion-of-cutaneous-squamous-cell-carcinoma
#9
Li-Qiang Zheng, Shan-Yi Li, Cheng-Xin Li
The aim of the present study was to identify the potential autophagy-related genes and to explore the underlying molecular mechanisms involved in cutaneous squamous cell carcinoma of head and neck (cSCCHN) by bioinformatics analysis. The Gene Expression Omnibus (GEO) series GSE86544 was downloaded from the GEO database. The primary data was generated from cSCCHN with clinical perineural invasion (PNI) and cSCCHN without PNI, and was further analyzed in order to identify differentially expressed genes (DEGs)...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29529119/primary-cutaneous-follicle-center-lymphoma-mimicking-folliculitis
#10
Ramya Chockalingam, Savina Aneja, Anisha B Patel
Primary cutaneous follicle center lymphoma (PCFCL) is the most common type of cutaneous B-cell lymphoma. The cutaneous manifestations of PCFCL typically include solitary erythematous or violaceous plaques, nodules, or tumors of varying sizes. Grouped lesions also may be observed, but multifocal disease is rare. We report the case of a 54-year-old woman diagnosed with PCFCL with an unusual clinical presentation resembling folliculitis or Grover disease. Histologic studies demonstrated extensive lymphoma cells in a nodular and diffuse pattern...
January 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29511289/novel-phosphorylated-tak1-species-with-functional-impact-on-nf-%C3%AE%C2%BAb-and-%C3%AE-catenin-signaling-in-human-cutaneous-t-cell-lymphoma
#11
Fernando Gallardo, Joan Bertran, Erika López-Arribillaga, Jéssica González, Silvia Menéndez, Ignacio Sánchez, Luis Colomo, Mar Iglesias, Marta Garrido, Luis Francisco Santamaría-Babí, Ferran Torres, Ramon M Pujol, Anna Bigas, Lluís Espinosa
Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies for the advanced forms of the disease (namely mycosis fungoides and the leukemic variant, Sézary syndrome). Molecular events leading to CTCL progression are heterogeneous, however recent DNA and RNA sequencing studies highlighted the importance of NF-κB and β-catenin pathways. We here show that the kinase TAK1, known as essential in B-cell lymphoma, is constitutively activated in CTCL cells, but tempered by the MYPT1/PP1 phosphatase complex...
February 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29508000/spontaneous-regression-of-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type
#12
Ferdinand Toberer, Gunhild Mechtersheimer, Hannah Jaschinski, Alexander Enk, Lara Hakim-Meibodi, Holger A Haenssle
No abstract text is available yet for this article.
March 2, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29500149/clinical-features-and-treatment-outcomes-of-primary-cutaneous-b-cell-lymphomas-a-thirty-year-experience
#13
Vittorio Stefoni, Alessandro Broccoli, Lisa Argnani, Elena Sabattini, Michele Cavo, Pier Luigi Zinzani
No abstract text is available yet for this article.
February 16, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29497455/primary-cutaneous-non-hodgkin-s-lymphoma-clinically-mimicking-a-soft-tissue-sarcoma
#14
Prajwala Gupta, Poojan Agarwal, Arvind Ahuja, C K Durga
Primary cutaneous B-cell lymphomas (PCBCL) are a heterogeneous group of neoplasms with distinct biology and clinical course when compared to their nodal counterparts. They usually present as violaceous, erythematous plaques, and nonulcerated nodules, which are confined to skin at the time of presentation. We present an unusual case of primary cutaneous diffuse large B-cell lymphoma, clinically mimicking a sarcoma. This case highlights the uncommon aggressive behavior and ulcerated type of nodular lesions seen in PCBCL and also revisits the cytomorphological findings of the same...
2018: CytoJournal
https://www.readbyqxmd.com/read/29494757/evaluation-of-treatment-results-in-multifocal-primary-cutaneous-anaplastic-large-cell-lymphoma-report-of-the-dutch-cutaneous-lymphoma-group
#15
R C Melchers, R Willemze, M W Bekkenk, E R M de Haas, B Horvath, M M van Rossum, C J G Sanders, J C J M Veraart, M H Vermeer, K D Quint
BACKGROUND: There is no consensus on the treatment of multifocal primary cutaneous anaplastic large cell lymphoma (C-ALCL). Radiotherapy (RT) and methotrexate (MTX) are the current treatment options, but their efficacy is unknown. Recently, targeted therapies showed promising results in C-ALCL, and may therefore be an attractive first choice of treatment. OBJECTIVES: To assess the efficacy of conventional treatment strategies for patients with multifocal C-ALCL, and to define which patients may require novel targeted therapies...
March 1, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29490369/methotrexate-associated-b-cell-lymphoproliferative-disease-in-a-patient-with-cutaneous-t-cell-lymphoma
#16
Andrea D Maderal, Janine C Malone, Jeffrey P Callen
No abstract text is available yet for this article.
February 28, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29484011/violet-colored-inguinal-located-cutaneous-tumour
#17
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Torello Lotti, Uwe Wollina, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Anaplastic large cell lymphoma (ALCL) represents an aggressive CD30 - positive T cell lymphoma, as it is the second most common T cell lymphoma and 2% to 5% of all non - Hodgkin lymphomas. The cutaneous involvement can be primary or secondary within systemic ALCL, resembling inflammatory and other neoplastic lesions both clinically and cytologically. Various pigmented cutaneous tumours with a different origin, cutaneous metastasis and B-cell lymphoma must be carefully considered in the differential diagnostic plan...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29469783/delayed-presentation-of-toxic-epidermal-necrolysis-like-cutaneous-acute-graft-versus-host-disease-in-the-setting-of-recent-immunosuppressant-discontinuation
#18
Parul K Kathuria Goyal, Shuai Xu, Jennifer Choi
Acute graft-versus-host disease (GvHD) is a process that classically has been defined as occurring less than 100 days after stem cell transplant. When Stage IV cutaneous acute GvHD occurs outside this window, it can be difficult to distinguish clinically from toxic epidermal necrolysis (TEN). A 50-year-old man with diffuse large B-cell lymphoma who had undergone an allogeneic stem cell transplant 20 months previously was admitted for neutropenic septic shock. He developed a slowly progressing macular/papular eruption with multiple tender bullae found to be consistent with TEN-like Stage IV cutaneous acute GvHD on biopsy...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29438091/a-phase-i-dose-escalation-study-of-clofarabine-in-patients-with-relapsed-or-refractory-low-grade-or-intermediate-grade-b-cell-or-t-cell-lymphoma
#19
Francine Marie Foss, Terri Parker
LESSONS LEARNED: Clofarabine can be active in relapsed and refractory lymphoid malignancies on a weekly dosing schedule.Responses were seen in patients with T-cell lymphomas, including cutaneous T-cell lymphoma, but not in patients with aggressive B-cell lymphomas. BACKGROUND: Clofarabine is a second-generation purine nucleoside analog currently approved for the treatment of pediatric relapsed or refractory acute lymphoblastic leukemia. In adults, clofarabine has been investigated in several phase I and II trials as a single agent and in combination for relapsed or refractory acute leukemia...
February 7, 2018: Oncologist
https://www.readbyqxmd.com/read/29422831/transformation-of-primary-cutaneous-follicle-centre-lymphoma-into-primary-cutaneous-diffuse-large-b-cell-lymphoma-of-other-type
#20
Ivan Z Petković, Ivica Pejčić, Danica Tiodorović, Miljan Krstić, Slavica Stojnev, Svetislav Vrbić
No abstract text is available yet for this article.
December 2017: Postȩpy Dermatologii i Alergologii
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