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Breast cancer in end stage renal failure

Bridgette E Drummond, Rebecca A Wingert
Specialized renal epithelial cells known as podocytes are essential components of the filtering structures within the kidney that coordinate the process of removing waste from the bloodstream. Podocyte loss initiates many human kidney diseases as it triggers subsequent damage to the kidney, leading to progressive loss of function that culminates with end stage renal failure. Podocyte morphology, function and gene expression profiles are well conserved between zebrafish and humans, making the former a relevant model to study podocyte development and model kidney diseases...
2018: Cancer Cell & Microenvironment
Benedict John Ho, Ramaswamy Akhileswaran, Grace Su Yin Pang, Gerald Choon Huat Koh
BACKGROUND: Hospice care is most appropriate when a patient no longer benefits from curative treatment and has limited life expectancy. These patients may suffer from any type of life-limiting illness, including end-stage cancer, end-stage heart disease, end-stage renal failure, AIDS, and Alzheimer's disease, among other illnesses. Patients are managed on their pain and symptoms and home hospice care manages these patients in the comfort of their own home, enabling patients to spend their last days with dignity and have a good quality of life...
May 2017: Journal of Palliative Medicine
Dr Charlotte Ratcliff, Miss Monica Hansrani
INTRODUCTION: This case report intends to highlight the Haemodialysis Reliable Outflow (HeRO) graft as a potential long term option for ongoing dialysis in patients with central venous stenosis. PRESENTATION OF CASE: A 55year old patient, who developed end stage renal failure (ESRF) after chemotherapy treatment for breast cancer, presented at the limit of her dialysis access after a 15year haemodialysis history causing central vein stenosis. The patient was initially started on peritoneal dialysis but after repeated peritonitis was switched to haemodialysis...
2016: International Journal of Surgery Case Reports
Salil V Deo, Sadeer G Al-Kindi, Guilherme H Oliveira
Rapid improvement in antineoplastic therapy is increasing not only cancer survivorship but also the incidence of end-stage heart failure among breast and childhood cancer survivors. Anthracyclines and newer targeted therapies, including trastuzumab and tyrosine kinase inhibitors, are important agents implemented in clinical practice that carry cardiotoxic risk. While acute heart failure is often self-limited and reversible, delayed-onset heart failure significantly reduces survival. Extremes of age, renal dysfunction, pre-existing coronary artery disease, HER2 positivity, and multi-drug therapy are predictors of irreversible heart failure after chemotherapy...
June 2015: Current Treatment Options in Cardiovascular Medicine
Anne M Butler, Andrew F Olshan, Abhijit V Kshirsagar, Jessie K Edwards, Matthew E Nielsen, Stephanie B Wheeler, M Alan Brookhart
BACKGROUND: Patients with end-stage renal disease (ESRD) receiving dialysis have been reported to have increased risk of cancer. However, contemporary cancer burden estimates in this population are sparse and do not account for the high competing risk of death characteristic of dialysis patients. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: US adult patients enrolled in Medicare's ESRD program who received in-center hemodialysis...
May 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Benjamin Farnia, K Ranh Voong, Paul D Brown, Pamela K Allen, Nandita Guha-Thakurta, Sujit S Prabhu, Ganesh Rao, Qianghu Wang, Zhongxiang Zhao, Anita Mahajan
OBJECT: The authors' institution previously reported a 69% rate of crude local control for surgical management of lateral ventricle metastases at the University of Texas MD Anderson Cancer Center. For comparison, the authors here report their institutional experience with use of stereotactic radiosurgery (SRS) to treat intraventricular metastases. METHODS: To identify patients with intraventricular metastases for this retrospective review, the authors queried an institutional SRS database containing the medical records of 1962 patients with 5800 brain metastases who consecutively underwent SRS from June 2009 through October 2013...
December 2014: Journal of Neurosurgery
M Gnant, B Mlineritsch, H Stoeger, G Luschin-Ebengreuth, M Knauer, M Moik, R Jakesz, M Seifert, S Taucher, V Bjelic-Radisic, M Balic, H Eidtmann, W Eiermann, G Steger, W Kwasny, P Dubsky, U Selim, F Fitzal, G Hochreiner, V Wette, P Sevelda, F Ploner, R Bartsch, C Fesl, R Greil
BACKGROUND: Zoledronic acid (ZOL) plus adjuvant endocrine therapy significantly improved disease-free survival (DFS) at 48- and 62-month follow-up in the ABCSG-12 trial. We present efficacy results of a final additional analysis after 94.4 months. PATIENTS AND METHODS: Patients were premenopausal women who had undergone primary surgery for stage I/II estrogen-receptor-positive and/or progesterone-receptor-positive breast cancer with <10 positive lymph nodes, and were scheduled for standard goserelin therapy...
February 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Desmond Y H Yap, Maggie K M Ma, Maggie M Y Mok, Lorraine P Y Kwan, Gary C W Chan, Tak Mao Chan
OBJECTIVE: Calcineurin inhibitors are effective immunosuppressants. They also reduce proteinuria in glomerular diseases but are potentially nephrotoxic. Short-term data suggest that tacrolimus (TAC) combined with corticosteroids is effective in LN, but long-term data are lacking. This study examined the long-term outcomes and tolerability of TAC for the treatment of LN. METHODS: We retrospectively reviewed 29 LN patients who received TAC treatment for 46.9 months (s...
December 2014: Rheumatology
Melissa L McPheeters, Sunil Kripalani, Neeraja B Peterson, Rachel T Idowu, Rebecca N Jerome, Shannon A Potter, Jeffrey C Andrews
OBJECTIVE: This review evaluates the effectiveness of quality improvement (QI) strategies in reducing disparities in health and health care. DATA SOURCES: We identified papers published in English between 1983 and 2011 from the MEDLINE® database, the Cumulative Index of Nursing and Allied Health Literature (CINAHL), Web of Science Social Science Index, and PsycINFO. REVIEW METHODS: All abstracts and full-text articles were dually reviewed...
August 2012: Evidence Report/technology Assessment
Diana Sarfati, Jason Gurney, Bee Teng Lim, Nasser Bagheri, Andrew Simpson, Jonathan Koea, Elizabeth Dennett
AIMS: Our study sought to optimize the identification and investigate the impact of comorbidity in cancer patients using routinely collected hospitalization data. METHODS: We undertook an iterative process of classification of important clinical conditions involving evaluation of relevant literature and consultation with clinicians. Patients diagnosed with colon, rectal, breast, ovarian, uterine, stomach, liver, renal or bladder cancers (n = 14,096) between 2006 and 2008 were identified from the New Zealand Cancer Registry...
March 2016: Asia-Pacific Journal of Clinical Oncology
Arielle C Dubose, Quyen D Chu, Benjamin D L Li, Roger H Kim
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for morbidity and mortality in multiple disease processes. However, not much is known about the relationship between breast cancer and CKD. CKD is associated with increased difficulty in breast cancer screening or surveillance due to increased calcifications on mammography. In addition, there is concern regarding the optimization of serum levels of chemotherapeutics in patients with CKD or on hemodialysis. We hypothesized that CKD is an independent risk factor for mortality in patients with breast cancer...
September 2013: Journal of Surgical Research
Shuo-Ming Ou, Yung-Tai Chen, Pei-Wen Chao, Yi-Jung Lee, Chia-Jen Liu, Chiu-Mei Yeh, Tzeng-Ji Chen, Tzen-Wen Chen, Wu-Chang Yang, Szu-Yuan Li
Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these patients. To identify any association between NSAID use and cancer risk in patients with end-stage renal disease on dialysis, we used Taiwan's National Health Insurance database to conduct a nationwide population-based, propensity score-matched cohort study...
July 2013: Kidney International
Justyna Janiszewska, Monika Lichodziejewska-Niemierko, Justyna Gołębiewska, Mikołaj Majkowicz, Bolesław Rutkowski
OBJECTIVE: Anxiety is the most frequent emotional reaction to the chronic somatic disease. However, little is known about anxiety and coping strategies in patients with end-stage renal disease (ESRD) undergoing renal replacement therapies (RRTs). The purpose of the study was to assess the intensity and determinants of anxiety in patients treated with different RRTs in comparison with end-stage breast cancer patients and healthy controls. METHODS: The study involved (1) ESRD patients undergoing different RRTs: 32 renal transplant recipients, 31 maintenance haemodialysis and 21 chronic peritoneal dialysis patients, (2) women with end-stage breast cancer (n = 25) and (3) healthy persons (n = 55)...
October 2013: International Urology and Nephrology
Kenar D Jhaveri, Carlos Flombaum, Manish Shah, Sheron Latcha
Capecitabine (Xeloda) is an orally administered precursor of 5'deoxy-5-fluorouridine, which is a preferentially activated to 5-fluorouracil in tumors. It is used in the treatment of colorectal, gastric, and breast cancers. Based on a single Phase II trial, which included a total of 4 patients with severe renal impairment (GFR <30 mL/min), the manufacturer issued a 'Dear Doctor' letter contraindicating the use of capecitabine in these patients since a high rate of grade 3 and 4 adverse events were observed and because these patients tolerated shorter treatment durations...
March 2012: Journal of Oncology Pharmacy Practice
Oded Olsha, Ilya Goldin, Vitaly Man, Moshe Carmon, David Shemesh
Breast cancer survivors who have had axillary lymph node dissection (ALND) and who later develop end-stage renal failure may eventually require hemodialysis access. If veins available for access in the contralateral arm have been exhausted, especially after chemotherapy, the ipsilateral arm will have to be considered for access construction. There are no evidence-based guidelines for lymphedema prevention, but there are sweeping recommendations to avoid physical injury to the ipsilateral limb, including needle puncture, after ALND with or without radiotherapy...
April 2012: Breast Cancer Research and Treatment
Pedro Iglesias, Juan J Carrero, Juan J Díez
Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifactorial in its origin, and rarely improves with initiation of dialysis, although it usually normalizes after renal transplantation. Experimental and clinical evidence suggests that testosterone may have important clinical implications with regards to kidney disease progression, derangements in sexual drive, libido and erectile dysfunction, development of anemia, impairment of muscle mass and strength, and also progression of atherosclerosis and cardiovascular disease...
January 2012: Journal of Nephrology
Ji-An Liang, Li-Min Sun, Jun-Jun Yeh, Fung-Chang Sung, Shih-Ni Chang, Chia-Hung Kao
OBJECTIVE: Patients with end-stage renal disease are suggestive to have a higher risk for the development of some kinds of cancer. The aim of this study is to evaluate the possible association between malignancy and end-stage renal disease in Taiwan. METHODS: We used the data of the National Health Insurance system of Taiwan to assess this issue. The end-stage renal disease cohort contained 21 817 patients, and each patient was randomly frequency-matched with two people from the general population without end-stage renal disease based on their age and sex...
June 2011: Japanese Journal of Clinical Oncology
Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP) was investigated. Membrane vesicles isolated from MRP4- or BCRP-overexpressing human embryonic kidney cells were used to study the impact of uremic toxins on substrate specific uptake. Furthermore, the concentrations of various uremic toxins were determined in plasma of CKD patients using high performance liquid chromatography and liquid chromatography/tandem mass spectrometry...
April 4, 2011: PloS One
Keiichirou Yamaguchi
Palliative therapy using radioactive strontium (89Sr) was performed on 60 patients suffering from cancer. Seventy-one percent of the patients had stopped or reduced their opiates and/or analgesics. Pain relief continued for up to three months. Patients with breast and prostatic cancer showed the best pain reduction. However, pain reduction was limited for lung cancer patients. Repeated usage of 89Sr with/without opiate and analgesics served to maintain the reduced level of pain. Side effects of repeated usage of 89Sr were decrease of hemoglobin, WBC, and platelets...
October 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Angela C Webster, Rajah Supramaniam, Dianne L O'Connell, Jeremy R Chapman, Jonathan C Craig
AIMS: End-stage kidney disease registries inform outcomes and policy. Data quality is crucial but difficult to measure objectively. We assessed agreement between incident cancer reported to the Australian and New Zealand Dialysis and Transplant Registry (ANZDATA) and to the Central Cancer Registry (CCR) in New South Wales. METHODS: ANZDATA records were linked to CCR using probabilistic matching. We calculated agreement between registries for patients with > or =1 cancers, all cancers and site-specific cancer using the kappa statistic (kappa)...
June 2010: Nephrology
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