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siddhartha mukherjee

Tanmoy Halder, Uttam Datta, Siddhartha Basu, Prasenjit Mukherjee
A wider biological role of ultratrace element lithium in the mammalian reproduction has been reported, however, presence of lithium in the epididymal luminal fluid (ELF) and its influence on sperm during maturation events in the epididymal regions are still unknown. A pilot study was carried out in Jamunapari buck which revealed that levels of lithium in the ELF diminished gradually and significantly (P<0.01) from caput to cauda epididymis, concomitantly, a distinct increase (P<0.01) in the spermatozoan motility, viability and hypo-osmotic reactive sperm were observed, except spermatozoan motility that was found absent in the caput epididymis...
November 2016: Medical Hypotheses
Siddhartha Pal, Somenath Lohar, Manjira Mukherjee, Pabitra Chattopadhyay, Koushik Dhara
A naphthalimide-based fluorescence light-up probe, FCP-Pd, has been designed and synthesized for selective detection and quantitation of creatinine in PBS buffer of pH 7.2 at 37 °C with a 'turn-on' response over a variety of interfering metal ions and/or anions and several biologically significant species. This probe is highly effective in estimating creatinine in human blood serum, which confirms the reliability and accuracy of this new system to be applied in clinical and toxicological analysis.
November 17, 2016: Chemical Communications: Chem Comm
David B Sykes, Youmna S Kfoury, François E Mercier, Mathias J Wawer, Jason M Law, Mark K Haynes, Timothy A Lewis, Amir Schajnovitz, Esha Jain, Dongjun Lee, Hanna Meyer, Kerry A Pierce, Nicola J Tolliday, Anna Waller, Steven J Ferrara, Ashley L Eheim, Detlef Stoeckigt, Katrina L Maxcy, Julien M Cobert, Jacqueline Bachand, Brian A Szekely, Siddhartha Mukherjee, Larry A Sklar, Joanne D Kotz, Clary B Clish, Ruslan I Sadreyev, Paul A Clemons, Andreas Janzer, Stuart L Schreiber, David T Scadden
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a powerful treatment strategy. We leveraged the observation that the majority of AML, despite their genetically heterogeneity, share in the expression of HoxA9, a gene normally downregulated during myeloid differentiation. Using a conditional HoxA9 model system, we performed a high-throughput phenotypic screen and defined compounds that overcame differentiation blockade...
September 22, 2016: Cell
Muhymin Islam, Rahul Atmaramani, Siddhartha Mukherjee, Santaneel Ghosh, Samir M Iqbal
Traumatic injury to the central nervous system is a significant health problem. There is no effective treatment available partly because of the complexity of the system. Implementation of multifunctional micro- and nano-device based combinatorial therapeutics can provide biocompatible and tunable approaches to perform on-demand release of specific drugs. This can help the damaged cells to improve neuronal survival, regeneration of axons, and their reconnection to appropriate targets. Nano-topological features induced rapid cell growth is especially important towards the design of effective platforms to facilitate damaged neural circuit reconstruction...
October 14, 2016: Nanotechnology
Sung Mi Park, Jianhong Ou, Lynn Chamberlain, Tessa M Simone, Huan Yang, Ching-Man Virbasius, Abdullah M Ali, Lihua Julie Zhu, Siddhartha Mukherjee, Azra Raza, Michael R Green
Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant and identify aberrantly processed pre-mRNAs by deep sequencing. We find that in U2AF35(S34F)-transformed cells the autophagy-related factor 7 (Atg7) pre-mRNA is abnormally processed, which unexpectedly is not due to altered splicing but rather selection of a distal cleavage and polyadenylation (CP) site...
May 19, 2016: Molecular Cell
Abhijit Halder, M S Sowmya, Abhimannyu Gayen, Popli Bhattacharya, Sanjay Mukherjee, Siddhartha Datta
OBJECTIVES: Evaluation and comparison of safety and efficacy of vaginal and intra-cesarean insertion of Post-Partum Intrauterine Contraceptive device (PPIUCD). METHODS: An interventional prospective study conducted in the Department of Obstetrics and Gynaecology at NRS Medical College, Kolkata. PPIUCD were inserted in 263 mothers in 1-year study period. Among them, first 100 mothers who delivered vaginally and the first 100 who underwent cesarean section were regarded as study groups and were followed up for 1 year...
February 2016: Journal of Obstetrics and Gynaecology of India
Siddhartha Sankar Boxi, Khushi Mukherjee, Santanu Paria
Chemical-based pesticides are widely used in agriculture to protect crops from insect infestation and diseases. However, the excessive use of highly toxic pesticides causes several human health (neurological, tumor, cancer) and environmental problems. Therefore nanoparticle-based green pesticides have become of special importance in recent years. The antifungal activities of pure and Ag doped (solid and hollow) TiO2 nanoparticles are studied against two potent phytopathogens, Fusarium solani (which causes Fusarium wilt disease in potato, tomato, etc) and Venturia inaequalis (which causes apple scab disease) and it is found that hollow nanoparticles are more effective than the other two...
February 26, 2016: Nanotechnology
Manjira Mukherjee, Buddhadeb Sen, Siddhartha Pal, Abhishek Maji, Darshita Budhadev, Pabitra Chattopadhyay
A structurally modified quinazoline derivative (L) acts as highly selective chemosensor for Al(3+) ions in DMSO-H2O (1:9, v/v) over the other competitive metal ions. L shows a red shifted fluorescence after the addition of Al(3+) ions and later the further fluorescence enhancement is due to chelation enhanced fluorescence (CHEF) through inhibition of photoinduced electron transfer (PET). This probe (L) detects Al(3+) ions as low as 9nM in DMSO-H2O (1:9, v/v) at biological pH. The non-cytotoxic probe (L) can efficiently detect the intercellular distribution of Al(3+) ions in living cells under a fluorescence microscope to exhibit its sensible applications in the biological systems...
March 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Xiaowei Chen, Michael J Churchill, Karan K Nagar, Yagnesh H Tailor, Timothy Chu, Brittany S Rush, Zhengyu Jiang, Edwin B C Wang, Bernhard W Renz, Hongshan Wang, Ming Chiu Fung, Daniel L Worthley, Siddhartha Mukherjee, Timothy C Wang
Food allergy can influence the development of colorectal cancer, although the underlying mechanisms are unclear. While mast cells (MC) store and secrete histamine, immature myeloid cells (IMC) are the major site of histidine decarboxylase (HDC) expression, the enzyme responsible for histamine production. From our earlier work, we hypothesized that histamine is central to the association between allergy and colorectal carcinogenesis through its influence on the MC-MDSC axis. Here, we show that in wild type (WT) mice, ovalbumin (OVA) immunization elicits a typical TH2 response...
October 20, 2015: Oncotarget
Siddhartha Das, Meneka Banik, Guang Chen, Shayandev Sinha, Rabibrata Mukherjee
Polyelectrolyte (PE) brushes are a special class of polymer brushes (PBs) containing charges. Polymer chains attain "brush"-like configuration when they are grafted or get localized at an interface (solid-fluid or liquid-fluid) with sufficiently close proximity between two-adjacent grafted polymer chains - such a proximity triggers a particular nature of interaction between the adjacent polymer molecules forcing them to stretch orthogonally to the grafting interface, instead of random-coil arrangement. In this review, we discuss the theory, synthesis, and applications of PE brushes...
November 28, 2015: Soft Matter
Siddhartha Mukherjee
No abstract text is available yet for this article.
September 10, 2015: Blood
Jian Zhang, Yen K Lieu, Abdullah M Ali, Alex Penson, Kathryn S Reggio, Raul Rabadan, Azra Raza, Siddhartha Mukherjee, James L Manley
Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these mutations affect SRSF2 function has only begun to be examined. We used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease to introduce the P95H mutation to SRSF2 in K562 leukemia cells, generating an isogenic model so that splicing alterations can be attributed solely to mutant SRSF2...
August 25, 2015: Proceedings of the National Academy of Sciences of the United States of America
Buddhadeb Sen, Manjira Mukherjee, Samya Banerjee, Siddhartha Pal, Pabitra Chattopadhyay
A newly designed fluorescent aluminum(III) complex (L'-Al; 2) of a structurally characterized non-fluorescent rhodamine Schiff base (L) has been isolated in pure form and characterized using spectroscopic and physico-chemical methods with theoretical density functional theory (DFT) support. On addition of Al(III) ions to a solution of L in HEPES buffer (1 mM, pH 7.4; EtOH-water, 1 : 3 v/v) at 25 °C, the systematic increase in chelation-enhanced fluorescence (CHEF) enables the detection of Al(III) ions as low as 60 nM with high selectivity, unaffected by the presence of competitive ions...
May 14, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Siddhartha Pal, Manjira Mukherjee, Buddhadeb Sen, Sushil Kumar Mandal, Somenath Lohar, Pabitra Chattopadhyay, Koushik Dhara
A coumarin-based fluorogenic probe, PCO-1, senses carbon monoxide (CO) selectively in HEPES buffer at pH 8.0 through the intramolecular cyclization-elimination pathway based on Pd(0) mediated reaction. The probe exhibits a 'turn-on' response of CO over a variety of relevant reactive oxygen, nitrogen and sulfur species.
March 14, 2015: Chemical Communications: Chem Comm
Shrikanta Chattopadhyay, Alison L Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A Hartwell, Peter G Miller, Radhika Subramanian, Leigh C Carmody, Rushdia Z Yusuf, David B Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D Cirstea, Teru Hideshima, Vlado Dančík, Max M Majireck, Mahmud M Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J Tolliday, Paul A Clemons, Malcolm A S Moore, Andrew M Stern, Alykhan F Shamji, Benjamin L Ebert, Todd R Golub, Noopur S Raje, David T Scadden, Stuart L Schreiber
Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance. One such compound, BRD9876, displayed selectivity over normal hematopoietic progenitors and was discovered to be an unusual ATP non-competitive kinesin-5 (Eg5) inhibitor. A novel mutation caused resistance, suggesting a binding site distinct from known Eg5 inhibitors, and BRD9876 inhibited only microtubule-bound Eg5...
February 4, 2015: Cell Reports
Wenhuo Hu, James Dooley, Stephen S Chung, Dhruva Chandramohan, Luisa Cimmino, Siddhartha Mukherjee, Christopher E Mason, Bart de Strooper, Adrian Liston, Christopher Y Park
Hematopoietic stem cells (HSCs) possess the ability to generate all hematopoietic cell types and to self-renew over long periods, but the mechanisms that regulate their unique properties are incompletely understood. Herein, we show that homozygous deletion of the miR-29a/b-1 bicistron results in decreased numbers of hematopoietic stem and progenitor cells (HSPCs), decreased HSC self-renewal, and increased HSC cell cycling and apoptosis. The HSPC phenotype is specifically due to loss of miR-29a, because miR-29b expression is unaltered in miR-29a/b-1-null HSCs, and only ectopic expression of miR-29a restores HSPC function both in vitro and in vivo...
April 2, 2015: Blood
Daniel L Worthley, Michael Churchill, Jocelyn T Compton, Yagnesh Tailor, Meenakshi Rao, Yiling Si, Daniel Levin, Matthew G Schwartz, Aysu Uygur, Yoku Hayakawa, Stefanie Gross, Bernhard W Renz, Wanda Setlik, Ashley N Martinez, Xiaowei Chen, Saqib Nizami, Heon Goo Lee, H Paco Kang, Jon-Michael Caldwell, Samuel Asfaha, C Benedikt Westphalen, Trevor Graham, Guangchun Jin, Karan Nagar, Hongshan Wang, Mazen A Kheirbek, Alka Kolhe, Jared Carpenter, Mark Glaire, Abhinav Nair, Simon Renders, Nicholas Manieri, Sureshkumar Muthupalani, James G Fox, Maximilian Reichert, Andrew S Giraud, Robert F Schwabe, Jean-Phillipe Pradere, Katherine Walton, Ajay Prakash, Deborah Gumucio, Anil K Rustgi, Thaddeus S Stappenbeck, Richard A Friedman, Michael D Gershon, Peter Sims, Tracy Grikscheit, Francis Y Lee, Gerard Karsenty, Siddhartha Mukherjee, Timothy C Wang
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes...
January 15, 2015: Cell
Siddhartha Pal, Buddhadeb Sen, Somenath Lohar, Manjira Mukherjee, Samya Banerjee, Pabitra Chattopadhyay
Copper(II) and copper(I) complexes of a newly designed and crystallographically characterized Schiff base (HL) derived from rhodamine hydrazide and cinnamaldehyde were isolated in pure form formulated as [Cu(L)(NO3)] (L-Cu) (1) and [Cu(HL)(CH3CN)(H2O)]ClO4 (HL-Cu) (2), and characterized by physicochemical and spectroscopic tools. Interestingly, complex 1 but not 2 offers red fluorescence in solution state, and eventually HL behaves as a Cu(II) ions selective FRET based fluorosensor in HEPES buffer (1 mM, acetonitrile-water: 1/5, v/v) at 25 °C at biological pH with almost no interference of other competitive ions...
January 28, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Anirban Das, Sabyasachi Choudhury, Sumitra Basuthakur, Anghsuman Mukhopadhyay, Siddhartha Mukherjee
Schwannomas are rare neurogenic tumor originating from Schwann cells of the nerve sheath, most frequently encountered type of posterior mediastinal tumors. In most cases, schwannomas are benign, malignant and multiple schwannomas are rare. Histopathologically, the tumor is composed of fascicles of spindle cells, which are strongly positive for S-100 proteins. Surgical resection is a treatment of choice, and prognosis is excellent. Here, we report a case of posterior mediastinal schwannoma in a 20- years old male patient who complained of right-sided back pain and two episodes of massive hemoptysis of recent onset...
November 2014: Archives of Iranian Medicine
Somenath Lohar, Siddhartha Pal, Buddhadeb Sen, Manjira Mukherjee, Samya Banerjee, Pabitra Chattopadhyay
A newly designed and structurally characterized cell permeable diformyl-p-cresol based receptor (HL) selectively senses the AsO3(3-) ion up to ca. 4.1 ppb in aqueous media over the other competitive ions at biological pH through an intermolecular H-bonding induced CHEF (chelation-enhanced fluorescence) process, established by detailed experimental and theoretical studies. This biofriendly probe is highly competent in recognizing the existence of AsO3(3-) ions in a living organism by developing an image under a fluorescence microscope and useful to estimate the amount of arsenite ions in various water samples...
November 18, 2014: Analytical Chemistry
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