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siddhartha mukherjee

Tamsin R M Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna Gieniec, Miao Yang, Jia Q Ng, Nobumi Suzuki, Mari Ichinose, Josephine A Wright, Hiroki Kobayashi, Tracey L Putoczki, Yoku Hayakawa, Simon J Leedham, Helen E Abud, Ömer H Yilmaz, Julie Marker, Sonja Klebe, Pratyaksha Wirapati, Siddhartha Mukherjee, Sabine Tejpar, Barbara A Leggett, Vicki L J Whitehall, Daniel L Worthley, Susan L Woods
OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF , and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progression and we begin to address this knowledge gap herein...
April 17, 2018: Gut
Evan D Morris
The Gene: An Intimate History by Siddhartha Mukherjee, first published in 2016, is a comprehensive and fascinating recounting of the discovery of the gene and genetics research from wrinkled peas to CRISPR/Cas9 and all the details in between. In Mukherjee's sweeping history, the science is clearly depicted but also tightly integrated into the political movements and world events that it spawned, both hopeful and detestable. Two stories from The Gene are the central focuses of this article. One story is driven by the desire of Eugenicists in early 20th century America to rid the population of defective traits...
December 2017: Yale Journal of Biology and Medicine
Xiaowei Chen, Huan Deng, Michael J Churchill, Larry L Luchsinger, Xing Du, Timothy H Chu, Richard A Friedman, Moritz Middelhoff, Hongxu Ding, Yagnesh H Tailor, Alexander L E Wang, Haibo Liu, Zhengchuan Niu, Hongshan Wang, Zhengyu Jiang, Simon Renders, Siu-Hong Ho, Spandan V Shah, Pavel Tishchenko, Wenju Chang, Theresa C Swayne, Laura Munteanu, Andrea Califano, Ryota Takahashi, Karan K Nagar, Bernhard W Renz, Daniel L Worthley, C Benedikt Westphalen, Yoku Hayakawa, Samuel Asfaha, Florence Borot, Chyuan-Sheng Lin, Hans-Willem Snoeck, Siddhartha Mukherjee, Timothy C Wang
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc+ myeloid cells lie in close anatomical proximity to MB-HSCs and produce histamine, which activates the H2 receptor on MB-HSCs to promote their quiescence and self-renewal...
December 7, 2017: Cell Stem Cell
Siddhartha Mukherjee, Sankha Shuvra Das, Jayabrata Dhar, Suman Chakraborty, Sunando DasGupta
We investigate electroosmotic flow of two immiscible viscoelastic fluids in a parallel plate microchannel. Contrary to traditional analysis, the effect of the depletion layer is incorporated near the walls, thereby capturing the complex coupling between rheology and electrokinetics. Toward ensuring realistic prediction, we show the dependence of electroosmotic flow rate on the solution pH and polymer concentration of the complex fluid. In order to assess our theoretical predictions, we have further performed experiments on electroosmosis of an aqueous solution of polyacrylamide (PAAm)...
October 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Tushar D Bhagat, Si Chen, Matthias Bartenstein, A Trevor Barlowe, Dagny Von Ahrens, Gaurav S Choudhary, Patrick Tivnan, Elianna Amin, A Mario Marcondes, Mathijs A Sanders, Remco M Hoogenboezem, Suman Kambhampati, Nandini Ramachandra, Iaonnis Mantzaris, Vineeth Sukrithan, Remi Laurence, Robert Lopez, Prafullla Bhagat, Orsi Giricz, Davendra Sohal, Amittha Wickrema, Cecilia Yeung, Kira Gritsman, Peter Aplan, Konrad Hochedlinger, Yiting Yu, Kith Pradhan, Jinghang Zhang, John M Greally, Siddhartha Mukherjee, Andrea Pellagatti, Jacqueline Boultwood, Britta Will, Ulrich Steidl, Marc H G P Raaijmakers, H Joachim Deeg, Michael G Kharas, Amit Verma
The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we conducted a DNA methylome analysis of bone marrow-derived stromal cells from myelodysplastic syndrome (MDS) patients and observed widespread aberrant cytosine hypermethylation occurring preferentially outside CpG islands...
September 15, 2017: Cancer Research
Amy E Caruso Brown, Rebecca Garden
Physicians' narratives of their own experiences of illness can be a kind of empathic bridge across the divide between a professional healer and a sick patient. This essay considers ways in which physicians' narratives of their own and family members' experiences of cancer shape encounters with patients and patients' experiences of illness. It analyzes ethical dimensions of physicians' narratives (such as those by Atul Gawande, Siddhartha Mukherjee, and Paul Kalanithi) and of reflective writing in medical education...
May 1, 2017: AMA Journal of Ethics
Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A Friedman, Timothy H Chu, Michael J Churchill, Yan Ma, Karan K Nagar, Yagnesh H Tailor, Siddhartha Mukherjee, Timothy C Wang
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting. We have identified a genetically and functionally distinct subset of dynamic bone marrow myeloid cells that are characterized by histidine decarboxylase (HDC) expression. Lineage tracing in Hdc-CreERT2;R26-LSL-tdTomato mice revealed that in homeostasis, there is a strong bias by HDC(+) myeloid cells toward the CD11b(+)Ly6G(hi) granulocytic lineage, which was accelerated during azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colonic carcinogenesis...
2017: Oncoimmunology
Sreekanth A Ramachandran, Pradeep S Jadhavar, Sandeep K Miglani, Manvendra P Singh, Deepak P Kalane, Anil K Agarwal, Balaji D Sathe, Kakoli Mukherjee, Ashu Gupta, Srijan Haldar, Mohd Raja, Siddhartha Singh, Son M Pham, Sarvajit Chakravarty, Kevin Quinn, Sebastian Belmar, Ivan E Alfaro, Christopher Higgs, Sebastian Bernales, Francisco J Herrera, Roopa Rai
Signaling via the receptor tyrosine kinase CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). TAMs play pro-tumorigenic roles, including the suppression of anti-tumor immune response, promotion of angiogenesis and tumor cell metastasis. Because of the role of this signaling pathway in the tumor microenvironment, several small molecule CSF1R kinase inhibitors are undergoing clinical evaluation for cancer therapy, either as a single agent or in combination with other cancer therapies, including immune checkpoint inhibitors...
May 15, 2017: Bioorganic & Medicinal Chemistry Letters
Walter Ling
A patient, long before becoming the subject of medical scrutiny is, at first simply a storyteller, a narrator of suffering-a traveler who has visited the kingdom of the ill. "To relieve an illness one must begin, then, by understanding the story." The Emperor of All Maladies; Siddhartha Mukherjee.
April 1, 2017: Drug and Alcohol Dependence
Stuart Weisberg, Michael Churchill, Adriana Colovai, Hanna Dobrowolska, Kenneth McCallum, Luliana Ionita-Laza, Govind Bhagat, Siddhartha Mukherjee, Boris Reizis
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
Tanmoy Halder, Uttam Datta, Siddhartha Basu, Prasenjit Mukherjee
A wider biological role of ultratrace element lithium in the mammalian reproduction has been reported, however, presence of lithium in the epididymal luminal fluid (ELF) and its influence on sperm during maturation events in the epididymal regions are still unknown. A pilot study was carried out in Jamunapari buck which revealed that levels of lithium in the ELF diminished gradually and significantly (P<0.01) from caput to cauda epididymis, concomitantly, a distinct increase (P<0.01) in the spermatozoan motility, viability and hypo-osmotic reactive sperm were observed, except spermatozoan motility that was found absent in the caput epididymis...
November 2016: Medical Hypotheses
Siddhartha Pal, Somenath Lohar, Manjira Mukherjee, Pabitra Chattopadhyay, Koushik Dhara
A naphthalimide-based fluorescence light-up probe, FCP-Pd, has been designed and synthesized for selective detection and quantitation of creatinine in PBS buffer of pH 7.2 at 37 °C with a 'turn-on' response over a variety of interfering metal ions and/or anions and several biologically significant species. This probe is highly effective in estimating creatinine in human blood serum, which confirms the reliability and accuracy of this new system to be applied in clinical and toxicological analysis.
November 17, 2016: Chemical Communications: Chem Comm
David B Sykes, Youmna S Kfoury, François E Mercier, Mathias J Wawer, Jason M Law, Mark K Haynes, Timothy A Lewis, Amir Schajnovitz, Esha Jain, Dongjun Lee, Hanna Meyer, Kerry A Pierce, Nicola J Tolliday, Anna Waller, Steven J Ferrara, Ashley L Eheim, Detlef Stoeckigt, Katrina L Maxcy, Julien M Cobert, Jacqueline Bachand, Brian A Szekely, Siddhartha Mukherjee, Larry A Sklar, Joanne D Kotz, Clary B Clish, Ruslan I Sadreyev, Paul A Clemons, Andreas Janzer, Stuart L Schreiber, David T Scadden
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a powerful treatment strategy. We leveraged the observation that the majority of AML, despite their genetically heterogeneity, share in the expression of HoxA9, a gene normally downregulated during myeloid differentiation. Using a conditional HoxA9 model system, we performed a high-throughput phenotypic screen and defined compounds that overcame differentiation blockade...
September 22, 2016: Cell
Muhymin Islam, Rahul Atmaramani, Siddhartha Mukherjee, Santaneel Ghosh, Samir M Iqbal
Traumatic injury to the central nervous system is a significant health problem. There is no effective treatment available partly because of the complexity of the system. Implementation of multifunctional micro- and nano-device based combinatorial therapeutics can provide biocompatible and tunable approaches to perform on-demand release of specific drugs. This can help the damaged cells to improve neuronal survival, regeneration of axons, and their reconnection to appropriate targets. Nano-topological features induced rapid cell growth is especially important towards the design of effective platforms to facilitate damaged neural circuit reconstruction...
October 14, 2016: Nanotechnology
Sung Mi Park, Jianhong Ou, Lynn Chamberlain, Tessa M Simone, Huan Yang, Ching-Man Virbasius, Abdullah M Ali, Lihua Julie Zhu, Siddhartha Mukherjee, Azra Raza, Michael R Green
Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant and identify aberrantly processed pre-mRNAs by deep sequencing. We find that in U2AF35(S34F)-transformed cells the autophagy-related factor 7 (Atg7) pre-mRNA is abnormally processed, which unexpectedly is not due to altered splicing but rather selection of a distal cleavage and polyadenylation (CP) site...
May 19, 2016: Molecular Cell
Abhijit Halder, M S Sowmya, Abhimannyu Gayen, Popli Bhattacharya, Sanjay Mukherjee, Siddhartha Datta
OBJECTIVES: Evaluation and comparison of safety and efficacy of vaginal and intra-cesarean insertion of Post-Partum Intrauterine Contraceptive device (PPIUCD). METHODS: An interventional prospective study conducted in the Department of Obstetrics and Gynaecology at NRS Medical College, Kolkata. PPIUCD were inserted in 263 mothers in 1-year study period. Among them, first 100 mothers who delivered vaginally and the first 100 who underwent cesarean section were regarded as study groups and were followed up for 1 year...
February 2016: Journal of Obstetrics and Gynaecology of India
Siddhartha Sankar Boxi, Khushi Mukherjee, Santanu Paria
Chemical-based pesticides are widely used in agriculture to protect crops from insect infestation and diseases. However, the excessive use of highly toxic pesticides causes several human health (neurological, tumor, cancer) and environmental problems. Therefore nanoparticle-based green pesticides have become of special importance in recent years. The antifungal activities of pure and Ag doped (solid and hollow) TiO2 nanoparticles are studied against two potent phytopathogens, Fusarium solani (which causes Fusarium wilt disease in potato, tomato, etc) and Venturia inaequalis (which causes apple scab disease) and it is found that hollow nanoparticles are more effective than the other two...
February 26, 2016: Nanotechnology
Manjira Mukherjee, Buddhadeb Sen, Siddhartha Pal, Abhishek Maji, Darshita Budhadev, Pabitra Chattopadhyay
A structurally modified quinazoline derivative (L) acts as highly selective chemosensor for Al(3+) ions in DMSO-H2O (1:9, v/v) over the other competitive metal ions. L shows a red shifted fluorescence after the addition of Al(3+) ions and later the further fluorescence enhancement is due to chelation enhanced fluorescence (CHEF) through inhibition of photoinduced electron transfer (PET). This probe (L) detects Al(3+) ions as low as 9nM in DMSO-H2O (1:9, v/v) at biological pH. The non-cytotoxic probe (L) can efficiently detect the intercellular distribution of Al(3+) ions in living cells under a fluorescence microscope to exhibit its sensible applications in the biological systems...
March 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Xiaowei Chen, Michael J Churchill, Karan K Nagar, Yagnesh H Tailor, Timothy Chu, Brittany S Rush, Zhengyu Jiang, Edwin B C Wang, Bernhard W Renz, Hongshan Wang, Ming Chiu Fung, Daniel L Worthley, Siddhartha Mukherjee, Timothy C Wang
Food allergy can influence the development of colorectal cancer, although the underlying mechanisms are unclear. While mast cells (MC) store and secrete histamine, immature myeloid cells (IMC) are the major site of histidine decarboxylase (HDC) expression, the enzyme responsible for histamine production. From our earlier work, we hypothesized that histamine is central to the association between allergy and colorectal carcinogenesis through its influence on the MC-MDSC axis. Here, we show that in wild type (WT) mice, ovalbumin (OVA) immunization elicits a typical TH2 response...
October 20, 2015: Oncotarget
Siddhartha Das, Meneka Banik, Guang Chen, Shayandev Sinha, Rabibrata Mukherjee
Polyelectrolyte (PE) brushes are a special class of polymer brushes (PBs) containing charges. Polymer chains attain "brush"-like configuration when they are grafted or get localized at an interface (solid-fluid or liquid-fluid) with sufficiently close proximity between two-adjacent grafted polymer chains - such a proximity triggers a particular nature of interaction between the adjacent polymer molecules forcing them to stretch orthogonally to the grafting interface, instead of random-coil arrangement. In this review, we discuss the theory, synthesis, and applications of PE brushes...
November 28, 2015: Soft Matter
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