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Malignant giant cell tumor

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https://www.readbyqxmd.com/read/29425276/giant-cell-tumor-of-bone-in-patients-55-years-and-older-a-study-of-34-patients
#1
Cory J Broehm, Carrie Y Inwards, Alyaa Al-Ibraheemi, Doris E Wenger, Sarah M Jenkins, Long Jin, Andre M Oliveira, Riyam T Zreik, Jodi M Carter, Jennifer M Boland, Karen J Fritchie
Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1)...
February 7, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29420837/carcinosarcoma-mimicking-a-feline-injection-site-sarcoma-in-a-cat
#2
Rafał Sapierzyński
A 15-year-old spayed female domestic short-haired cat with cutaneous/subcutaneous well-circumscribed, alopecic mass approximately 25 × 30 mm in diameter, localized to the left shoulder region was brought to the veterinary surgery department. Despite the suggestive location and macroscopic appearance, feline injection-site sarcoma was not suspected based on the cytologic examination of fine-needle aspirates. The tumor was surgically resected, and tissue sections were evaluated microscopically. The tumor was found to be nonencapsulated with a distinct border between the neoplastic parenchyma and surrounding connective tissue...
February 8, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29416163/fibulectomy-for-primary-proximal-fibular-bone-tumors-a-functional-and-clinical-outcome-in-46-patients
#3
Zile Singh Kundu, Milind Tanwar, Parveen Rana, Rajeev Sen
Background: Primary benign and malignant tumors of the proximal fibula are not very common. Upper fibula being an expendable bone; the majority of the primary bone tumors at this site are usually treated with en bloc proximal fibulectomy. There is scarce literature on functional results, difficulties faced during dissection when to preserve or sacrifice common peroneal nerve and importance of lateral collateral ligament repair after proximal fibulectomy. The present study attempts at assessing these variables...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29390282/giant-solitary-fibrous-tumor-of-the-pleura-with-high-grade-sarcomatous-overgrowth-accompanied-by-lipid-rich-rhabdomyosarcomatous-and-pleomorphic-components-a-case-report
#4
Takeo Nakaya, Hisashi Oshiro, Ayako Takigami, Yoshihiko Kanai, Kenji Tetsuka, Koichi Hagiwara, Hirofumi Fujii, Shunsuke Endo, Akira Tanaka
RATIONALE: Solitary fibrous tumors are mesenchymal tumors presenting as fibroblastic neoplasms with prominent branching vascular patterns, which are often generated from the pleura. Most solitary fibrous tumors are benign; however, some can turn malignant. High-grade sarcomas from solitary fibrous tumors include multidirectional histopathological components. PATIENT CONCERNS: We describe our experience of a giant high-grade sarcoma with mixed components generated from a solitary fibrous tumor of the pleura in a 67-year-old female patient presenting with cough and left-sided chest pain...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387393/denosumab-as-a-potential-therapeutic-option-for-leiomyosarcoma-with-osteoclast-like-giant-cells-a-case-report
#5
Taro Sasaki, Hiroyuki Kawashima, Takashi Ariizumi, Tetsuro Yamagishi, Naoki Oike, Hajime Umezu, Shyoichi Inagawa, Tetsuo Hotta, Naoto Endo, Akira Ogose
Bone leiomyosarcoma is a rare primary osseous malignant tumor with a high metastatic potential. Similar to other bone sarcomas, high histological grade and tumor stage are predictive of a poor outcome. We herein present our experience with treating a 64-year-old woman with bone leiomyosarcoma accompanied by multiple bone metastases. A biopsy revealed occasional osteoclast-like giant cells. In addition to radiation therapy, the osteoclastogenesis inhibitor denosumab was administered but the patient did not undergo adjuvant chemotherapy or surgery...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29356963/pathologic-conditions-of-hard-tissue-role-of-osteoclasts-in-osteolytic-lesion
#6
REVIEW
Riko Kitazawa, Ryuma Haraguchi, Mana Fukushima, Sohei Kitazawa
Hard tissue homeostasis is regulated by the balance between bone formation by osteoblasts and bone resorption by osteoclasts. This physiologic process allows adaptation to mechanical loading and calcium homeostasis. Under pathologic conditions, however, this process is ill-balanced resulting in either over-resorption or over-formation of hard tissue. Local over-resorption by osteoclasts is typically observed in osteolytic metastases of malignancies, autoimmune arthritis, and giant cell tumor of bone (GCTB)...
January 22, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29332062/cytologic-features-of-malignant-melanoma-with-osteoclast-like-giant-cells
#7
José A Jiménez-Heffernan, Magdalena Adrados, Patricia Muñoz-Hernández, Paloma Fernández-Rico, Ana I Ballesteros-García, Javier Fraga
BACKGROUND: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. CASE: A 57-year-old woman presented with an inguinal lymphadenopathy. Sixteen years before, cutaneous malignant melanoma of the lower limb had been excised...
January 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#8
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29310408/case-report-repairing-orbital-skin-defects-using-composite-flaps-after-giant-eyelid-derived-tumor-excision-and-orbital-exenteration
#9
Bin Fan, Jian-Ju Liu, Bei-Fen Wang, Ying-Jian Sun, Guang-Yu Li
RATIONALE: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy. PATIENT CONCERNS: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Clinical examination revealed a huge pigmented, nonhealing ulcerated lesion, approximately 52×44×40 mm in size...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29296223/development-and-validation-of-a-prognostic-index-to-predict-pulmonary-metastasis-of-giant-cell-tumor-of-bone
#10
Bo Wang, Wei Chen, Xianbiao Xie, Jian Tu, Gang Huang, Changye Zou, Junqiang Yin, Lili Wen, Jingnan Shen
Purpose: Giant cell tumor of bone (GCTB) is an intermittent tumor with a low probability of pulmonary metastasis. Our aim was to investigate the risk factors and establish a nomogram predictive model for GCTB pulmonary metastasis. Methods: We retrospectively evaluated GCTB patients at our center from 1991 to 2014. The cohort was randomized into training and validation sets. Univariate and multivariate analyses were used to evaluate the risk factors of pulmonary metastasis...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291377/giant-intracardiac-smooth-muscle-cell-tumor-presenting-as-superior-vena-cava-syndrome
#11
Alejandro E Murillo-Berlioz, Kyongjune Benjamin Lee, Gregory D Trachiotis, Klaus Kühn
We report the case of a 53-year-old male presenting with a superior vena cava syndrome secondary to a giant intracardiac mass occupying the majority of the right cavities of the heart. A mass of 10.5 cm x 9.5 cm x 4.0 cm originating from the superior vena cava and occupying most of the right atrium, extending through the tricuspid valve into the right ventricle. The mass was resected and the patient was discharged on postoperative day eleven. Pathology report revealed the mass to be a smooth-muscle cell tumor of unknown malignant potential (STUMP)...
December 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29280702/effective-management-of-extensive-tissue-loss-after-abdominoperineal-resection-for-buschke-loewenstein-tumor
#12
G Balducci, G Carbotta, M G Sederino, A Delvecchio, R Laforgia, P Sallustio, P Lobascio, F Ferrarese, M Minafra, S Fedele, N Palasciano
The giant condyloma acuminatum or Buschke-Loewenstein tumor is a rare, sexually transmitted disease. It is an epithelial tumor characterized by its high potential of malignancy towards developing into a highly invasive squamous cell carcinoma. The present case concerns a drug addicted 40-year-old man who smuggled drugs using his rectum. He had a partially ulcerated mass in the perianal area of about 20 x 10 cm. He reported a progressive growth of this neoplasm during the last 3 years associated with perianal pain, obstructed defecation, bad sitting posture, no fever and weight loss...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29241742/diagnostic-utility-of-histone-h3-3g34-w-g34r-and-g34-v-mutant-specific-antibodies-for-giant-cell-tumors-of-bone
#13
Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kohashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda
Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation. The RANKL inhibitor denosumab, when used for the treatment of GCTB, leads to histological changes such as new bone formation and giant cell depletion. Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3.3G34 W, G34R and G34 V mutant proteins for GCTB and other histologically similar bone and joint lesions...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29202683/successful-use-of-snare-electrocautery-via-flexible-fiberoptic-bronchoscopy-for-removal-of-an-endobronchial-hamartoma-causing-chronic-lung-atelectasis-and-mimicking-malignancy
#14
Chao Liu, Jia-Jia Wang, Ye-Han Zhu, Cheng Chen
We present a rare case of giant endobronchial hamartoma coexisting with lung atelectasis for more than 3 years. The small specimen initially biopsied via bronchoscope did not reveal tissue features, but some features were suspicious for squamous cell carcinoma. The lesion was removed completely using snare electrocautery combined with argon plasma coagulation via flexible fiberoptic bronchoscopy. The patient made a satisfactory recovery, and a pathological diagnosis was made. This could be a useful option in selected endobronchial tumors...
December 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29181359/articular-reconstruction-using-subchondral-cementation-and-threaded-kirschner-wires-in-giant-cell-tumor-a-novel-technique
#15
Padmanabh H Vora, Rameez Musa, Neel M Bhavsar, Darshan Shah
Introduction: Giant Cell Tumor(GCT) is one of an infrequently encountered tumor by orthopaedic surgeons in clinical practice. It is described as 'locally malignant' tumor found in epimetaphyseal region of long bones, peculiarly around knee. We present a case of a solitary, benign Campanacci Grade 2 GCT in right lateral femoral condyle in 38 year old female and our treatment. Case Report: A 38 year old female presented to our outpatient department with chief complaint of constant, moderate pain in right knee increasing in duration since 3 months...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29160138/a-case-of-dedifferentiated-chondrosarcoma-arising-in-the-cricoid-cartilage-that-mimicked-an-aneurysmal-bone-cyst
#16
Lixiao Chen, Ziwei Yu, Rui Jiang, Pin Dong, Bin Shen, Yu Li
Dedifferentiated chondrosarcoma of the larynx is a rare and highly malignant tumor. We present the report of a 59-year-old man with dedifferentiated laryngeal chondrosarcoma, which was difficult to diagnose even under microscopic examination. The original diagnosis was an aneurysmal bone cyst, and the final diagnosis was established only after careful consideration of the imaging, surgical, and microscopic findings. In clinical practice, there are many similarities between dedifferentiated chondrosarcoma and aneurysmal bone cysts...
November 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29136686/-clinicopathologic-and-molecular-characteristics-of-malignant-gastrointestinal-neuroectodermal-tumors
#17
M Zhao, T W Zhao, J Ma, C Y Wu, L Chen, G Q Ru, X L He
Objective: To investigate the clinicopathologic and molecular characteristics, diagnostic, differential diagnostic and prognostic features of malignant gastrointestinal neuroectodermal tumor. Methods: Two cases of malignant gastrointestinal neuroectodermal tumor were retrieved; the clinical and radiologic features, histomorphology, immunophenotype, molecular genetics and prognosis were analyzed and the relevant literature reviewed. Results: Case 1 was a 57-year-old male, presented with recurrent abdominal pain and melena...
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29123414/low-grade-central-osteosarcoma-in-proximal-humerus-a-rare-entity
#18
Fan Tang, Li Min, Yong Zhou, Yi Luo, Chongqi Tu
Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Local tumor recurrences often exhibited a tumor with higher histologic grade or differentiation with the potential for metastases. In low-grade central osteosarcoma, timely wide resection after definite diagnosis can result in 5-year survival for almost 90%...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29114282/multicompartmental-primary-spinal-extramedullary-tumors-value-of-an-interdisciplinary-approach
#19
Guruprasad Bettaswamy, Paurush Ambesh, Raj Kumar, Rabi Narayan Sahu, Kuntal Kanti Das, Awadhesh Kumar Jaiswal, Arun Kumar Srivastava, Sanjay Behari
Background: Primary extramedullary tumors involving multiple compartments around the spine are a technically demanding group of tumors whose extent traverses beyond the normal confines of those anatomical regions which fall in the common domain of neurosurgeons. In the following series, we present 12 patients who were diagnosed with primary spinal extramedullary tumors with multicompartmental extension, and whose surgical management was facilitated by a combined multidisciplinary approach involving surgeons of other superspecialties...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29107018/flubendazole-induces-mitotic-catastrophe-and-apoptosis-in-melanoma-cells
#20
K Čáňová, L Rozkydalová, D Vokurková, E Rudolf
Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group. Recently, several studies have been published demonstrating its potential to inhibit growth of various tumor cells including those derived from colorectal cancer, breast cancer or leukemia via several mechanisms. In the present study we have investigated cytotoxic effects of FLU on malignant melanoma using A-375, BOWES and RPMI-7951 cell lines representing diverse melanoma molecular types. In all three cell lines, FLU inhibited cell growth and proliferation and disrupted microtubule structure and function which was accompanied by dramatic changes in cellular morphology...
October 26, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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