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Malignant giant cell tumor

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https://www.readbyqxmd.com/read/29672549/tumor-development-in-japanese-patients-with-lynch-syndrome
#1
Chiaki Saita, Tatsuro Yamaguchi, Shin-Ichiro Horiguchi, Rin Yamada, Misato Takao, Takeru Iijima, Rika Wakaume, Tomoyuki Aruga, Taku Tabata, Koichi Koizumi
BACKGROUND: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients. METHODS: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. RESULTS: The median age at the diagnosis of the first malignant tumor and first LS-related tumor was 44 (range, 19-65) and 44 (range, 24-66) years, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29663145/successful-treatment-of-a-diffuse-type-tenosynovial-giant-cell-tumor-in-the-thoracic-spine-mimicking-spinal-metastasis-by-frozen-recapping-laminoplasty-in-a-patient-with-thyroid-cancer
#2
REVIEW
Noritaka Yonezawa, Hideki Murakami, Satoshi Kato, Hiroyuki Hayashi, Hiroyuki Tsuchiya
PURPOSE: Tenosynovial giant cell tumor of the diffuse type (TGCT-D) involving the spine is rare. Its differential diagnosis includes metastatic disease; however, there have been few reports of spinal TGCT-D mimicking spinal metastasis in patients with a history of malignancy. METHODS: We report on a 35-year-old woman with a history of papillary thyroid cancer who was diagnosed with TGCT-D of the thoracic spine mimicking spinal metastasis. Preoperative computed tomography (CT) revealed a 1...
April 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29600686/-treatment-progress-on-giant-cell-tumors-of-bone
#3
REVIEW
Peng Liang
Giant cell tumors(GCT) of bone is benign bone tumors with aggressive and osteolytic activity. As traditional treatment of GCT, removal of bone graft is disease with high local recurrence rate, and could reduce local recurrence by auxiliary means. Different surgical methods such as prosthesis replacement, wide resection and En-bloc resection could be selected for different parts of giant cell tumor of bone, based on the lesion location, size, extent of invasion, recurrence rate. For patients with special region of GCT of bone with removed incompletely and high surgical risk expected, arterial embolism could be performed...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29589985/a-giant-dermoid-cyst-of-the-orbit
#4
Bipasha Mukherjee, Akruti Desai
To describe a unique case of a non-germinomatous germ cell tumor, a giant orbital dermoid, present in adulthood. A 31-year-old male presented in our clinic with gradual, painless, progressive proptosis in the left eye since 28 years associated with gradual loss of vision. The left eye showed gross proptosis. Ocular structures could not be made out. Computed tomography scan showed a well-circumscribed oval heterogeneous mixed solid and cystic lesion completely filling the left orbit with calcification. The differential diagnosis was that of either teratoma or optic nerve glioma...
March 28, 2018: Orbit
https://www.readbyqxmd.com/read/29580573/-benign-and-malignant-giant-cell-rich-lesions-of-bone-pathological-diagnosis-with-special-emphasis-on-recent-immunohistochemistry-and-molecular-techniques
#5
Nicolas Macagno, Kevin Caselles, Sébastien Aubert, Virginie Audard, Anne Gomez-Brouchet, Christine Galant, Jean-Marc Guinebretière, Marie Karanian, Frédérique Larousserie, Béatrice Marie, Gonzague de Pinieux, Corinne Bouvier
The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Amongst malignant neoplasms, variants of conventional osteosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma and bone metastasis must be discussed...
March 23, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29535423/jnk-and-yorkie-drive-tumor-progression-by-generating-polyploid-giant-cells-in-drosophila
#6
Bojie Cong, Shizue Ohsawa, Tatsushi Igaki
Epithelial cancer tissues often possess polyploid giant cells, which are thought to be highly oncogenic. However, the mechanisms by which polyploid giant cells are generated in tumor tissues and how such cells contribute to tumor progression remain elusive. We previously noticed in Drosophila imaginal epithelium that cells mutant for the endocytic gene rab5 exhibit enlarged nuclei. Here we find that mutations in endocytic 'neoplastic tumor-suppressor' genes, such as rab5, vps25, erupted, or avalanche result in generation of polyploid giant cells...
March 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29534353/-langerhans-cell-sarcoma-a-clinicopathologic-analysis-of-four-cases
#7
H J Huang, X Y Chen, Z Y Zheng
Objective: To investigate the clinicopathological features, differential diagnosis, and genetic alteration of Langerhans cell sarcoma (LCS). Methods: Four cases of LCS were collected from Fujian Provincial Hospital and Fuzhou General Hospital of Nanjing Military Command of PLA from July 2013 to January 2017. Clinicopathological features and immunophenotype were retrospectively reviewed in four LCS cases combined with genetic mutation analysis of BRAF and ALK. Results: Four cases included 2 women and 2 men with ages from 42 to 79 years (median=59...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29533276/giant-pilomatricoma-arising-as-a-rapidly-growing-vascularized-tumor-in-a-child
#8
Alexandra Yannoutsos, Julie Malloizel-Delaunay, Emilie Tournier, Abdelaziz Abid, Alessandra Bura-Rivière
In this observation, we report an unusual presentation of a pilomatricoma in an 8-year-old girl who was initially referred to the department of vascular medicine for diagnosis and care of a suspected mixed lymphatic venous malformation. The lesion on her left shoulder presented as a giant bluish-purple red solitary mass, painful and rapidly growing, measuring 7 cm in anteroposterior diameter. This mass did not present the typical characteristics of a lymphatic venous malformation but exhibited warning signs of malignancy on clinical examination and imaging...
February 27, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29529630/can-aortic-balloon-occlusion-reduce-blood-loss-during-resection-of-sacral-tumors-that-extend-into-the-lower-lumber-spine
#9
Yidan Zhang, Wei Guo, Xiaodong Tang, Rongli Yang, Taiqiang Yan, Sen Dong, Shidong Wang, Nikolas Zaphiros
BACKGROUND: Although aortic balloon occlusion has been shown to reduce blood loss during sacral tumor resections, it has not been validated in larger sacral tumors involving the lower lumbar spine. If such an approach were shown to be associated with less blood loss, it might aid the tumor surgeon in resecting these difficult tumors. QUESTIONS/PURPOSES: (1) Is the use of aortic balloon occlusion associated with reduced blood loss in sacral tumor resections when the lower lumbar spine is also involved? (2) Does the use of the aortic balloon prolong total operating time? (3) What complications are associated with the use of a balloon? METHODS: We retrospectively studied all 56 patients diagnosed with sacral tumors involving the lower lumbar spine (L4, L5) who were treated surgically between 2004 and 2015 at our institute...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29510588/current-molecular-targeted-therapies-for-bone-and-soft-tissue-sarcomas
#10
REVIEW
Kenji Nakano, Shunji Takahashi
Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. These cancers presented challenges in new drug development partly because of their rarity and heterogeneity. Many new molecular targeting drugs have been tried in the 2010s, and some were approved for bone and soft tissue sarcoma. As one of the first molecular targeted drugs approved for solid malignant tumors, imatinib's approval as a treatment for gastrointestinal stromal tumors (GISTs) has been a great achievement...
March 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29489027/extraskeletal-osteosarcoma-mdm2-and-h3k27me3-analysis-of-19-cases-suggest-disease-heterogeneity
#11
Naohiro Makise, Masaya Sekimizu, Takashi Kubo, Susumu Wakai, Shun-Ichi Watanabe, Tomoyasu Kato, Takayuki Kinoshita, Nobuyoshi Hiraoka, Masashi Fukayama, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
AIMS: Extraskeletal osteosarcoma (ESOS) is a sarcoma in the non-skeletal tissue that directly produces neoplastic osteoid or bone. Dedifferentiated liposarcoma (DDLPS) and malignant peripheral nerve sheath tumor (MPNST) are the two most common types of sarcoma that can harbor heterologous osteosarcomatous differentiation. We aimed to determine the potential relationship of ESOS to DDLPS and MPNST. METHODS AND RESULTS: We investigated MDM2 and H3K27me3 status in 19 cases of ESOS, 2 of which contained a low-grade component...
February 28, 2018: Histopathology
https://www.readbyqxmd.com/read/29484233/giant-malignant-fibrous-histiocytoma-of-the-testis
#12
Volkan Ülker, Hasan Anıl Atalay, Çağlar Çakır, Aytül Sargan
We present a case of malignant fibrous histiocytoma of the testis in a 59 year- old male who admitted to our hospital with left testicular painless mass presenting for two months. A scrotal ultrasound examination and magnetic resonance imaging revealed a 9 cm left testicular solid mass. Serum tumor markers were unremarkable. The patient underwent left radical orchiectomy. Histopathologic diagnosis was giant cell variant of malignant fibrous histiocytoma which composed of varying amounts of a mixture of spindled, rounded and osteoclastic type giant cells...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29481473/fortuitous-administration-of-denosumab-in-breast-carcinoma-with-osteoclastic-giant-cells
#13
Ilit Turgeman, Ezequiel Flechter, Eugene Vlodavsky, Daniela Militianu, Zohar Keidar, Elias Haddad, Gil Bar-Sela
Breast carcinoma with osteoclastic giant cells (OGCs) is a rare entity characterized by an admixture of giant cells and malignant epithelial cells within an inflammatory and vascular stroma. Denosumab is a monoclonal antibody that targets the pathway for osteoclast formation and activation, indicated for the prevention of skeletal-related events in patients with bone metastases, as well as for the treatment of giant cell tumor of bone. We report a patient who presented with aggressive bone recurrence of breast cancer 12 years after her original diagnosis, showing a transformed histology that included multinucleated OGCs, and that was refractory to traditional therapy...
February 23, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29479542/giant-condylomata-acuminata-of-buschke-lowenstein-associated-with-paraneoplastic-hypercalcemia
#14
Fredrick Venter, Arash Heidari, Macsen Viehweg, Mark Rivera, Piruthiviraj Natarajan, Everardo Cobos
Low-risk human papillomavirus types 6 and 11 can manifest as giant condylomata acuminata (GCA) of Buschke-Lowenstein. Up to 50% of GCA can slowly progress over years to fungating, invasive tumors. The malignant potential is attributed to unique immune evading abilities of the human papillomavirus. A 42-year-old male presented with pain and foul-smelling discharge from his genital warts. The histopathological examination of the mass showed invasive squamous cell carcinoma, and it was associated with paraneoplastic hypercalcemia...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29463803/alcam-stromal-cells-role-in-giant-cell-tumor-of-bone-progression
#15
Zhenhua Zhou, Yan Li, Xudong Wang, Jingjing Hu, Muyu Kuang, Zhiwei Wang, Song Li, Weidong Xu, Jianru Xiao
Giant cell tumor of bone(GCTB) is a special benign tumor with variable aggressiveness and recurrence rate. Increasing evidences suggest that a subset of cells called cancer stem cells (CSCs) are present as cancer-initiating cells in a range of malignant tumors. However, the role of CSCs in benign tumor such as GCTB remains unknown, and the connection between the presence of CSCs and biological characteristics of GCTB is unclear. To investigate this issue, we screened a panel of markers of normal stem cells and CSCs and found ALCAM+ stromal cells possessed characteristics of stem-like cells...
February 20, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29425276/giant-cell-tumor-of-bone-in-patients-55-years-and-older-a-study-of-34-patients
#16
Cory J Broehm, Carrie Y Inwards, Alyaa Al-Ibraheemi, Doris E Wenger, Sarah M Jenkins, Long Jin, Andre M Oliveira, Riyam T Zreik, Jodi M Carter, Jennifer M Boland, Karen J Fritchie
Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1)...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29420837/carcinosarcoma-mimicking-a-feline-injection-site-sarcoma-in-a-cat
#17
Rafał Sapierzyński
A 15-year-old spayed female domestic short-haired cat with cutaneous/subcutaneous well-circumscribed, alopecic mass approximately 25 × 30 mm in diameter, localized to the left shoulder region was brought to the veterinary surgery department. Despite the suggestive location and macroscopic appearance, feline injection-site sarcoma was not suspected based on the cytologic examination of fine-needle aspirates. The tumor was surgically resected, and tissue sections were evaluated microscopically. The tumor was found to be nonencapsulated with a distinct border between the neoplastic parenchyma and surrounding connective tissue...
February 8, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29416163/fibulectomy-for-primary-proximal-fibular-bone-tumors-a-functional-and-clinical-outcome-in-46-patients
#18
Zile Singh Kundu, Milind Tanwar, Parveen Rana, Rajeev Sen
Background: Primary benign and malignant tumors of the proximal fibula are not very common. Upper fibula being an expendable bone; the majority of the primary bone tumors at this site are usually treated with en bloc proximal fibulectomy. There is scarce literature on functional results, difficulties faced during dissection when to preserve or sacrifice common peroneal nerve and importance of lateral collateral ligament repair after proximal fibulectomy. The present study attempts at assessing these variables...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29390282/giant-solitary-fibrous-tumor-of-the-pleura-with-high-grade-sarcomatous-overgrowth-accompanied-by-lipid-rich-rhabdomyosarcomatous-and-pleomorphic-components-a-case-report
#19
Takeo Nakaya, Hisashi Oshiro, Ayako Takigami, Yoshihiko Kanai, Kenji Tetsuka, Koichi Hagiwara, Hirofumi Fujii, Shunsuke Endo, Akira Tanaka
RATIONALE: Solitary fibrous tumors are mesenchymal tumors presenting as fibroblastic neoplasms with prominent branching vascular patterns, which are often generated from the pleura. Most solitary fibrous tumors are benign; however, some can turn malignant. High-grade sarcomas from solitary fibrous tumors include multidirectional histopathological components. PATIENT CONCERNS: We describe our experience of a giant high-grade sarcoma with mixed components generated from a solitary fibrous tumor of the pleura in a 67-year-old female patient presenting with cough and left-sided chest pain...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387393/denosumab-as-a-potential-therapeutic-option-for-leiomyosarcoma-with-osteoclast-like-giant-cells-a-case-report
#20
Taro Sasaki, Hiroyuki Kawashima, Takashi Ariizumi, Tetsuro Yamagishi, Naoki Oike, Hajime Umezu, Shyoichi Inagawa, Tetsuo Hotta, Naoto Endo, Akira Ogose
Bone leiomyosarcoma is a rare primary osseous malignant tumor with a high metastatic potential. Similar to other bone sarcomas, high histological grade and tumor stage are predictive of a poor outcome. We herein present our experience with treating a 64-year-old woman with bone leiomyosarcoma accompanied by multiple bone metastases. A biopsy revealed occasional osteoclast-like giant cells. In addition to radiation therapy, the osteoclastogenesis inhibitor denosumab was administered but the patient did not undergo adjuvant chemotherapy or surgery...
January 2018: Molecular and Clinical Oncology
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