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Malignant giant cell tumor

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https://www.readbyqxmd.com/read/28199754/multinucleated-giant-cell-reaction-in-lower-lip-squamous-cell-carcinoma-a-clinical-morphological-and-immunohistochemical-study
#1
Hellen Bandeira de Pontes Santos, Márcia Cristina da Costa Miguel, Leão Pereira Pinto, Manuel Antonio Gordón-Núñez, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
BACKGROUND: Multinucleated giant cell (MGC) reactions have been identified in several malignancies, but their frequency and significance in lower lip squamous cell carcinoma (SCC) are not established. This study evaluated the MGC reactions and their association with clinicopathological parameters in lower lip SCCs. The polarization profile of these cells (M1 or M2 macrophages) was also assessed. METHODS: The presence and distribution of MGC reactions in high-power fields (400×) were evaluated in hematoxylin/eosin-stained histological sections of 91 lower lip SCCs...
February 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28195259/telangiectatic-osteosarcoma-of-the-rib-a-rare-entity-and-a-potential-diagnostic-pitfall
#2
I Saguem, L Ayadi, R Kallel, S Charfi, I Bahri, N Gouiaa, T Sellami-Boudawara
Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. The rib involvement is very infrequent. We present a case of TOS of the rib that posed a diagnostic difficulty owing to its unusual location and to its resemblance to giant cell tumor and aneurysmal bone cyst...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28185423/granulocyte-colony-stimulating-factor-producing-pancreatic-anaplastic-carcinoma-in-ascitic-fluid-at-initial-diagnosis-a-case-report
#3
Nao Kubota, Yoshiki Naito, Akihiko Kawahara, Tomoki Taira, Tomohiko Yamaguchi, Tomoko Yoshida, Hideyuki Abe, Yorihiko Takase, Chihiro Fukumitsu, Kazuya Murata, Yusuke Ishida, Yoshinobu Okabe, Yoshizo Kimura, Masahiko Tanigawa, Yutaro Mihara, Masamichi Nakayama, Rin Yamaguchi, Jun Akiba, Hirohisa Yano
Granulocyte colony-stimulating factor (G-CSF)-producing pancreatic tumors are extremely rare. These tumors have an aggressive clinical course and no established treatment. Here, we report an autopsy case of G-CSF-production in pancreatic anaplastic carcinoma (PAC). A 72-year-old woman presented with a large pancreatic head mass and multiple liver metastases. Laboratory data showed leukocytosis (leukocyte count 113.3 × 10(3) /µL) and high serum G-CSF levels (441 pg/mL; normal range: <39.0 pg/mL). The ascitic fluid was submitted to our pathology laboratory at initial diagnosis...
February 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28182061/intraoperative-squash-cytology-and-histology-of-giant-cell-ependymoma-a-diagnostic-dilemma
#4
Ebru Cakir, Ulku Kucuk, Ayca Ersen, Emel E Pala, Mehmet Senoglu, Ali O Binatli, Zubeyde Yildirim
Giant cell ependymomas (GCE) are extremely rare tumors, with 24 cases described in the literature. Squash cytology is a rapid, reliable, simple technique for intraoperative consultation in neurosurgical practice. We describe a rare case of GCE arising at level of L4-L5 in a 66-year-old woman and discuss the cytologic/histologic features. Intraoperative smears were highly cellular with a prominent fibrillary background and exhibited papillary structures and sheets composed of highly atypical and bizarre cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28180935/clinicopathological-features-and-microsurgical-outcomes-for-giant-pediatric-intracranial-tumor-in-60-consecutive-cases
#5
Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo
PURPOSE: Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality. METHODS: The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed. RESULTS: Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection...
February 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28133333/-a-case-report-of-difficult-esophagojejunal-anastomosis-for-multiple-primary-cancer-of-malignant-lymphoma-and-gastric-cancer
#6
Masanori Yamada, Koji Nakai, Kentaro Inoue, Takeshi Hijikawa, Hiroaki Kitade, Kazuyoshi Ishii, Kazuhiko Yoshioka, Masanori Kon
A 54-year-old man presented with cervical lymph node swelling and exhibited high levels of sIL-2R. Enhanced cervical, chest, and abdominal CT scanning demonstrated swelling of the cervical, hilar, axilla, and abdominal lymph nodes. The patient was diagnosed with malignant, non-Hodgkin's lymphoma, B-cell, follicular lymphoma using biopsy of the cervical lymph nodes. Gastrointestinal endoscopy revealed II c like advanced tumor in the upper gastric body and post-wall area. He was diagnosed with primary multiple cancer comprising malignant lymphoma and gastric cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133249/-a-giant-malignant-lymphoma-of-the-ileocecum-treated-with-laparoscopic-surgery
#7
Yoshito Nako, Shigeki Yamazaki, Takashi Kitade, Tomoki Hariu, Motomi Wakasa, Masayoshi Nakanishi, Teruhisa Sonoyama
We experienced a case ofa giant malignant lymphoma ofthe ileocecum treated with laparoscopic surgery. A 78-year-old man presented with right flank pain. Lower endoscopy and abdominal computed tomography revealed a giant tumor in ileocecum. Biopsy results suggested malignant lymphoma or adenocarcinoma. We performed a laparoscopic ileocecal resection for definite diagnosis and treatment. The postoperative course was uneventful. The pathological diagnosis was malignant diffuse large B-cell lymphoma. The patient underwent chemotherapy and is being followed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28112040/intralymphatic-histiocytosis-of-the-appendix-and-fallopian-tube-associated-with-primary-peritoneal-high-grade-poorly-differentiated-adenocarcinoma-of-m%C3%A3-llerian-origin
#8
Tien Anh N Tran, Quang Tran, J Andrew Carlson
Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literature. To date, ILH has not been described in an internal visceral organ. We report the case of a 68-year-old woman who underwent an appendectomy during a surgical procedure for a primary peritoneal high-grade, poorly differentiated adenocarcinoma of Müllerian origin...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28088216/immunohistochemical-features-of-giant-cell-ependymoma-of-the-filum-terminale-with-unusual-clinical-and-radiological-presentation
#9
Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga, Armando Gamboa-Dominguez
BACKGROUND: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior. CASE PRESENTATION: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion...
January 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28071641/epidemiological-data-and-case-load-spectrum-of-patients-presenting-to-bone-and-soft-tissue-disease-management-group-at-a-tertiary-cancer-center
#10
A Gulia, A Puri, S Chorge, P K Panda
INTRODUCTION AND BACKGROUND: This study was conducted to know the spectrum and number of bone and soft tissue (BST) tumors presenting to our institute. We needed to assess the gap between the number of patients seen and infrastructure available, and based on this information, help formulate guidelines for optimum utilization of resources and to provide best possible evidence-based cancer care. SETTINGS AND DESIGNS: This is a prospective observational study (epidemiological)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28041320/image-guided-resection-of-aggressive-sacral-tumors
#11
Doniel Drazin, Neil Bhamb, Lutfi T Al-Khouja, Ari D Kappel, Terrence T Kim, J Patrick Johnson, Earl Brien
OBJECTIVE The aim of this study was to identify and discuss operative nuances utilizing image guidance in the surgical management of aggressive sacral tumors. METHODS The authors report on their single-institution, multi-surgeon, retrospective case series involving patients with pathology-proven aggressive sacral tumors treated between 2009 and 2016. They also reviewed the literature to identify articles related to aggressive sacral tumors, their diagnosis, and their surgical treatment and discuss the results together with their own experience...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/27989786/malignant-tenosynovial-giant-cell-tumor-with-cdkn2a-b-genomic-alteration-a-histological-immunohistochemical-and-molecular-study
#12
Borislav A Alexiev, Yanki Tumer, Guang-Yu Yang
Diffuse-type tenosynovial giant cell tumor (D-T TSGCT) is regarded as a benign but locally aggressive neoplasm with significant recurrent potential. We report a case of malignant (D-T TSGCT with pleural metastases arising in the left knee in a 57-year-old male. The tumor demonstrated atypical features, including a solid infiltrative pattern with spindling of the tumor cells, nuclear pleomorphism with prominent nucleoli, and markedly increased mitotic activity (>20 mitoses/10 HPF). The immunoprofile demonstrated clusterin+, D2-40+, CD68+, p63+, MDM2+, p16- tumor...
December 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27987512/-diagnosis-and-treatment-of-diffuse-tenosynovial-giant-cell-tumor-arising-from-temporomandibular-joints
#13
J H Meng, Y X Guo, H Y Luo, C B Guo, X C Ma
OBJECTIVE: To retrospectively analyze the clinical features, treatment and prognosis to the diffuse tenosynovial giant cell tumor (D-TSGCT) arising from the temporomandibular joint (TMJ), and to give a reference for the early diagnosis and treatment of this disease. METHODS: In this study, 15 patients finally diagnosed as D-TSGCT of TMJ histopathologically at the Peking University Hospital of Stomatology from October 2003 to August 2015 were selected and reviewed...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27932163/testicular-seminoma-occurring-after-kidney-transplantation-in-a-patient-previously-treated-for-teratoma-de-novo-malignancy-or-recurrence-in-a-different-histologic-form
#14
I Juric, N Basic-Jukic
The most common testicular tumor is seminoma, but it is one of the rarest malignancies in kidney transplant recipients, with only 15 cases published in the English-language literature. Except in 1 case of recurrence, all cases were de novo malignancies after transplantation. We bring a case of a patient treated for testicle teratoma at age 24 years who received a kidney transplant at age 40 years, and 19 months after transplantation was diagnosed with a metastatic seminoma. To the best of our knowledge, there are no data of germ cell tumor late recurrence after kidney transplantation...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27910166/anchored-multiplex-pcr-for-targeted-next-generation-sequencing-reveals-recurrent-and-novel-usp6-fusions-and-upregulation-of-usp6-expression-in-aneurysmal-bone-cyst
#15
Natalya V Guseva, Omar Jaber, Munir R Tanas, Aaron A Stence, Ramakrishna Sompallae, Jenna Schade, Allison N Fillman, Benjamin J Miller, Aaron D Bossler, Deqin Ma
Primary aneurysmal bone cyst (ABC) is a neoplastic process due to recurrent translocations involving the USP6 gene. By fluorescence in situ hybridization, up to 69% of primary ABCs harbored USP6 translocations; no USP6 translocation was found in secondary ABC or giant cell tumor of bone (GCT). GCT can recur locally, metastasize to the lungs in some cases, and rarely undergo malignant transformation. Differentiating primary ABC from its mimics is important for treatment and prognosis. We evaluated USP6 fusion and expression in 13 cases of primary and 1 case of secondary ABC, and 9 cases of GCT using nucleic acid extracted from formalin-fixed, paraffin-embedded tissue and a next generation sequencing (NGS)-based assay...
November 7, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27907819/giant-primary-malignant-mesothelioma-of-the-liver-a-case-report
#16
Ruba Haji Ali, Mohamad Khalife, Ghina El Nounou, Ruba Zuhri Yafi, Hussein Nassar, Zeinab Aidibe, Randa Raad, Rania Abou Eid, Walid Faraj
INTRODUCTION: Malignant mesothelioma is a rare neoplasm of mesothelial cells arising most frequently in the pleura or peritoneum and less frequently in the liver. CASE PRESENTATION: We present a case of primary hepatic mesothelioma of 41year old woman. She had no history of asbestos exposure or cancer. Abdominal computed tomography (CT) showed 21cm intrahepatic mass in the right lobe with many cystic lesions and few small calcifications. Pathology showed a biphasic cellular pattern...
November 11, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27864816/giant-insulinoma-report-of-a-case-and-review-of-published-reports
#17
Kazumitsu Ueda, Tetsuro Taira, Hiroyuki Hakoda, Shoko Nakata, Shinya Okata, Takeshi Nagai, Shigeo Aoki, Hideyuki Mishima, Akihiko Sako, Tsunehiko Maruyama, Minoru Okumura
BACKGROUND: Larger insulinomas are reportedly more likely to be malignant; however, their biological behavior has not been clearly elucidated. We here report the characteristics and treatment of a giant insulinoma with local invasion and lymph node metastasis. We also review published reports concerning the clinical features of giant insulinomas and comparing their grading with that of pancreatic neuroendocrine tumors. CASE PRESENTATION: A 71-year-old man was referred to our hospital for investigation of persistent hypoglycemia...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27862217/genome-wide-transcriptome-profiling-of-the-neoplastic-giant-cell-tumor-of-bone-stromal-cells-by-rna-sequencing
#18
Carol Py Lau, Jamie Sl Kwok, Joseph Cc Tsui, Lin Huang, Kevin Y Yang, Stephen Kw Tsui, Shekhar Madhukar Kumta
Giant cell tumor of bone (GCTB) is the most common non-malignant primary bone tumor reported in Hong Kong. Failure of treatment in advanced GCTB with aggressive local recurrence remains a clinical challenge. In order to reveal the molecular mechanism underlying the pathogenesis of this tumor, we aimed to examine the transcriptome profiling of the neoplastic stromal cells of GCTB in this study. RNA-sequencing was performed on three GCTB stromal cell samples and one bone marrow-derived MSC sample and 174 differentially expressed genes (DEGs) were identified between these two cell types...
November 15, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27846455/case-report-of-the-positive-exostosin-1-without-b-cell-lymphoma-2-gene-expression-of-giant-cell-tumor-lesion-in-hereditary-multiple-exostosis
#19
I Gede Eka Wiratnaya, Nyoman Gede Aditya Gitapradita B, I G N Yudhi Setiawan, I Ketut Suyasa, I Ketut Siki Kawiyana, Putu Astawa
INTRODUCTION: The giant cell tumor, in which BCL-2 gene was expressed only in its malignant transformation, is a benign, primary skeletal neoplasm with variable biologic aggressiveness. The is of the giant cell tumor. A coexistence with hereditary multiple exostosis with expression of EXT-1 is very rare. The correlation between giant cell tumor in hereditary multiple exostosis is still not clearly determined. PRESENTATION OF CASE: A 31-years-old female presented with pain and lump on her left wrist and a coexistence of non tender multiple lump in the right and left knee...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27843459/tumor-budding-micropapillary-pattern-and-polyploidy-giant-cancer-cells-in-colorectal-cancer-current-status-and-future-prospects
#20
REVIEW
Shiwu Zhang, Dan Zhang, Zhengduo Yang, Xipeng Zhang
We previously reported that polyploid giant cancer cells (PGCGs) induced by CoCl2 could form through endoreduplication or cell fusion. A single PGCC formed tumors in immunodeficient mice. PGCCs are also the key contributors to the cellular atypia and associate with the malignant grade of tumors. PGCCs have the properties of cancer stem cells and produce daughter cells via asymmetric cell division. Compared with diploid cancer cells, these daughter cells express less epithelial markers and acquire mesenchymal phenotype with importance in cancer development and progression...
2016: Stem Cells International
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