D Westphal, M Garzarolli, M Sergon, P Horak, B Hutter, J C Becker, M Wiegel, E Maczey, S Blum, S Grosche-Schlee, A Rütten, S Ugurel, A Stenzinger, H Glimm, D Aust, G Baretton, S Beissert, S Fröhling, S Redler, H Surowy, F Meier
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare skin cancer arising from the eccrine sweat glands. Due to the lack of effective therapies, metastasis is associated with a high mortality rate. OBJECTIVES: To investigate the drivers of EPC progression. METHODS: We carried out genomic and transcriptomic profiling of metastatic EPC (mEPC), validation of the observed alterations in an EPC patient-derived cell line, confirmation of relevant observations in a large patient cohort of 30 tumour tissues, and successful treatment of a patient with mEPC under the identified treatment regimens...
December 2021: British Journal of Dermatology