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Porocarcinoma treatment

Hiren Mandaliya, Ina Nordman
The successful treatment of the rare malignancy eccrine porocarcinoma (EP) is extremely challenging, often not rewarding and when associated with metastatic disease, therapy results are disappointing. We present a unique case of treatment response of metastatic EP, with a significant disease-free interval. The patient has remained in clinical and radiological remission for 36 months since diagnosis of metastatic disease.
May 2016: Case Reports in Oncology
Amer Raheemullah, Shyam Allamaneni, Steven Weber, Ranjodh Singh
Eccrine porocarcinoma is a rare tumor that arises from the epithelium of the eccrine ducts, with a tendency for metastatic spread and a high rate of local recurrence after excision. It was first described in 1963 by Pinkus and Mehregan and can present clinically as a nodule, erosive plaque or a polypoid growth that may ulcerate. The variable clinical appearance of these lesions can make diagnosis challenging and could delay appropriate treatment. If metastasis occurs the prognosis is poor, with a reported mortality rate of up to 80%...
September 1, 2016: Journal of Hand Surgery
Wineeta Melgandi, Rony Benson, Abdul Hakin, Suman Bhasker
Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the intra dermal part of the gland and accounts for only 0.005% of all epithelial cutaneous tumors. Commonly involved site includes extremities and face. Scalp is a rare site for porocarcinoma with less than 20 reported cases so far. Wide local excision with clear margins remains the treatment of choice. Review of literature revealed a local recurrence rate of 37.5% and a nodal involvement risk of 20%. Porocarcinoma of the scalp is peculiar in that the primary tumor may be large at presentation, making surgery with adequate margins difficult...
September 2016: Journal of the Egyptian National Cancer Institute
Stanislav N Tolkachjov, Thomas L Hocker, Michael J Camilleri, Christian L Baum
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare malignant adnexal neoplasm with reported metastatic potential and undefined optimal treatment. OBJECTIVE: This study reviews the clinical characteristics and outcomes of patients with EPC treated with Mohs micrographic surgery (MMS). MATERIALS AND METHODS: The authors performed a retrospective chart review of patients with EPC treated by MMS at the Mayo Clinic from 1995 to 2013, recording patient demographics, tumor characteristics, MMS stages to clearance, follow-up, recurrence, metastasis, and mortality...
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Narendrasinh Parmar, Mohamed Mohamed, Adel Elmoghrabi, Michael McCann
INTRODUCTION: Eccrine porocarcinoma (EPC) is a rare malignancy of eccrine sweat glands. It is often seen during the sixth to eighth decades of life. We report the first case of eccrine porocarcinoma arising on the abdomen of a 21-year-old patient with ulcerative colitis. CASE PRESENTATION: A 21-Year-old female presented to emergency department with a one month history of an enlarging mass over left lower abdomen. Abdominal examination revealed a slightly erythematous, nodular and non-mobile firm mass in left lower quadrant...
2016: International Journal of Surgery Case Reports
Nalli R Sumitra Devi, K Valarmathi, Mary Lilly, Selvi Satish, Nidhi Mishra
Eccrine porocarcinoma, a rare cutaneous malignant tumour accounts for a fraction of sweat gland tumours. This tumour is found to originate from the intraepithelial parts of the sweat glands. It commonly involves the lower extremities in elderly patients and carries an aggressive behaviour. Cutaneous and visceral metastasis can occur and hence prompt treatment is mandatory. Surgical excision is the mainstay of treatment modality. We hereby present a case of eccrine porocarcinoma in a 50-year-old male in the right axillary region presenting as a verrucous lesion...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
Andrea Montes-Torres, Alejandra Pérez-Plaza, Mar Llamas-Velasco, Carlos Gordillo, Diego De Argila, Carmen García-García, Javier Fraga, Alicia Marín, Ana Isabel Ballesteros, Esteban Daudén
BACKGROUND: Eccrine porocarcinoma (EPC) is an uncommon malignant neoplasm that originates in the intraepidermal portion of the eccrine sweat duct. Although porocarcinoma is a slow-growing tumor, up to 20% of cases can metastasize to regional lymph nodes, thus increasing mortality. METHODS: We describe the clinical and histopathological features and clinical course of three cases of extensive metastatic EPC diagnosed in our department over the last 10 years. RESULTS: All three patients were women aged 89-96 years...
March 2016: International Journal of Dermatology
Aida Acosta-Arencibia, Begoña Abrante-Expósito, Matilde Ramos-Gordillo
BACKGROUND: Eccrine porocarcinoma, first described in 1963, is a rare malignant lesion arising from the eccrine sweat glands. It is usually a primary tumour, or even more common, a malignant degeneration of an eccrine poroma. It usually affects older persons and is located most commonly on the lower extremities. About 20% of eccrine porocarcinoma will recur after treatment. The treatment is wide local excision of the primary lesion. This uncommon skin tumour has a locally aggressive behaviour and a high recurrence rate...
January 2016: Cirugia y Cirujanos
William D Longhurst, Amor Khachemoune
There is little discussion of tumors arising in the digits in the dermatology literature. The patient with an undifferentiated mass of the finger is frequently encountered in the clinic, and variances in presentation of common and uncommon entities pose a challenge that may prompt further investigation for proper diagnosis and treatment. In this review, the authors illustrate the approach and work-up of an unknown digit mass of a 45-year-old female patient. They go on to discuss the presentation and treatment of common tumor lesions of the finger likely to be encountered in the dermatologist's clinic including: ganglion cyst/mucous cyst, giant-cell tumor, verruca vulgaris, epidermal inclusion cyst, poroma, porocarcinoma, squamous cell carcinoma, basal cell carcinoma, melanoma, infantile digital fibromatosis, acquired digital fibrokeratoma, Koenen's tumor, schwannoma, cutaneous neurofibroma, pyogenic granuloma, hemangioma, glomus tumor, epithelioid sarcoma, and metastatic disease...
November 2015: International Journal of Dermatology
William James Tidwell, Jonathan E Mayer, Janine Malone, Courtney Schadt, Timothy Brown
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare malignant tumor of the eccrine sweat gland. It is a potentially fatal neoplasm that is locally aggressive and commonly recurs. Wide surgical excision has traditionally been the treatment of choice and is curative in approximately 70-80% of cases. The disease is metastatic to lymph nodes and distant sites in 20% and 10% of cases, respectively. Metastatic EPC has not shown any great response to adjuvant chemotherapy or radiation. OBJECTIVE: The purpose of this study was to evaluate the efficacy of Mohs micrographic surgery (MMS) for EPC as an alternative to wide local excision...
September 2015: International Journal of Dermatology
Yaohui G Xu, Juliet Aylward, B Jack Longley, Molly A Hinshaw, Stephen N Snow
BACKGROUND: Eccrine porocarcinoma (EPC) has a poor prognosis after standard wide local excision (WLE), with 20% local recurrence, 20% regional and 12% distant metastatic rates. Mohs micrographic surgery (MMS) has been used as a promising treatment. OBJECTIVE: To review the use of MMS for EPC and assess treatment outcomes. MATERIALS AND METHODS: This was a retrospective case series of 12 EPC patients treated by MMS between 1984 and 2013 in the institution...
June 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Silvia Soohyun Song, Wiggin Wu Lee, Michael Shane Hamman, Shang I Brian Jiang
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare malignancy of the eccrine sweat glands that is locally aggressive with a high propensity to metastasize. Most cases have been treated by wide local excision (WLE) with 20% local recurrence rate. There have been 20 cases of EPC treated with Mohs micrographic surgery (MMS) in the literature. OBJECTIVE: To review the literature regarding the management of this aggressive tumor using MMS. METHODS: A comprehensive literature review was conducted by searching the PubMed database using the keywords Mohs, porocarcinoma, malignant eccrine poroma, and eccrine neoplasms...
March 2015: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Lorenzo Borgognoni, Borgognoni Lorenzo, Leonardo Pescitelli, Pescitelli Leonardo, Carmelo Urso, Urso Carmelo, Paola Brandani, Brandani Paola, Serena Sestini, Sestini Serena, Cristina Chiarugi, Chiarugi Cristina, Riccardo Gelli, Gelli Riccardo, Vanni Giannotti, Giannotti Vanni, Gianni Gerlini, Gerlini Gianni
We report the case of an old woman with an eccrine porocarcinoma unusually localized in the perianal area treated by electrochemotherapy, a new technique, emerging as a very effective local treatment of different skin metastases and selected primary tumors. Electrochemotherapy was performed taking into account patient wishes and refusal of demolitive surgery. The electrochemotherapy treatment was well tolerated by the patient, it gave an excellent clinical response and a complete clinical regression with no sphincter dysfunction and signs of relapse observed during follow-up...
December 2014: Future Oncology
Francesca De Iuliis, Lucrezia Amoroso, Ludovica Taglieri, Stefania Vendittozzi, Luciana Blasi, Gerardo Salerno, Rosina Lanza, Susanna Scarpa
Malignant skin adnexal tumors are rare neoplasms which are derived from adnexal epithelial structures of the skin: hair follicle, or sebaceous, apocrine or eccrine glands. Among them, eccrine porocarcinoma is the most frequent, with an aggressive behavior compared to other more common forms of non-melanoma skin cancer. Only few reports describe the treatment of metastatic adnexal tumors, and there is no consensus about the better strategy of chemotherapy. Given the few cases and the absence of randomized clinical trials, it is important to collect clinical experiences on these tumors...
October 2014: Anticancer Research
A Ponzetti, S Ribero, V Caliendo, R Spadi, G Macripò, P Lista
Eccrine porocarcinoma is a rare and aggressive skin neoplasm;; only two cases of sarcomatous differentiation have been reported. Whereas surgery is effective as first line treatment, optimal management of recurrent or metastatic porocarcinoma is not defined and needs multidisciplinary approach. Here we described the first reported case of metastatic sarcomatoid porocarcinoma. Our patient experienced multiple recurrences, mainly loco--regional, and was treated with a multidisciplinary treatment, involving surgery, radiotherapy, chemotherapy and target therapy, leading to a more than 4 years survival, from the first recurrence...
September 18, 2014: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Taku Fujimura, Akira Hashimoto, Sadanori Furudate, Yumi Kambayashi, Takahiro Haga, Setsuya Aiba
Eccrine porocarcinoma is a rare type of skin cancer that originates from eccrine sweat glands or acrosyringium and mainly occurs in the elderly. In this report, we describe an 85-year-old Japanese woman with eccrine porocarcinoma that metastasized to a cervical lymph node who was cured with CyberKnife radiosurgery. Because our patient had a high risk of perioperative complication, standard surgical therapy with a wide margin was impractical. Our present study suggests the novel possibility of using CyberKnife for the treatment of inoperable metastatic porocarcinoma...
May 2014: Case Reports in Dermatology
Yota Sato, Taku Fujimura, Erika Tamabuchi, Takahiro Haga, Setsuya Aiba
Hidroacanthoma simplex (HAS), also known as intraepidermal eccrine poroma, is a rare eccrine adnexal tumor that tends to be misdiagnosed as other types of benign skin tumor, including clonal seborrheic keratosis. Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma. Therefore, accurate diagnosis of HAS is indispensable for dermatologists to avoid the development of malignant tumors by an unsuitable treatment. In this report, we present the characteristic dermoscopy findings of HAS...
May 2014: Case Reports in Dermatology
Nina S Müller, Carolin Zschoche, Wolfgang Hartschuh, Anke S Lonsdorf
No abstract text is available yet for this article.
February 2015: Acta Dermato-venereologica
Meredith Barnes, Andrea Hestley, Douglas R Murray, Grant W Carlson, Doug Parker, Keith A Delman
Malignant cutaneous adnexal tumors (MCATs) are rare neoplasms that do not have a well-studied treatment algorithm. They are generally treated by excision alone. Given its successful application in other cutaneous malignancies, sentinel lymph node biopsy (SLNB) has been advocated by some for use in MCATs. A retrospective chart review was performed. Clinicopathological factors, recurrence patterns, and long-term follow-up were documented. Survival analysis was performed. Forty-eight subjects were identified. Mean age was 69 years with locations on the face (52%), including periocular sites (16%), extremities (25%), and all other sites (7%)...
March 2014: American Surgeon
Mitsuaki Ishida, Hidetoshi Okabe
Porocarcinoma is a rare skin appendage carcinoma, with a poor prognosis. At present, the recommended treatment of localized porocarcinoma is wide surgical resection. Although anthracyclin-based chemotherapy or combination of 5-fluorouracil (5-FU), taxanes and cisplatin are considered to be the first-line treatment for metastatic or locally-advanced porocarcinoma, this type of tumor is recognized as relatively chemoresistant, and no standard systemic treatment has been established yet. Mammalian target of rapamycin (mTOR) is an important protein involved in carcinogenesis...
January 2013: Biomedical Reports
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