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https://www.readbyqxmd.com/read/29156565/survey-on-the-performance-of-source-localization-algorithms
#1
José Manuel Fresno, Guillermo Robles, Juan Manuel Martínez-Tarifa, Brian G Stewart
The localization of emitters using an array of sensors or antennas is a prevalent issue approached in several applications. There exist different techniques for source localization, which can be classified into multilateration, received signal strength (RSS) and proximity methods. The performance of multilateration techniques relies on measured time variables: the time of flight (ToF) of the emission from the emitter to the sensor, the time differences of arrival (TDoA) of the emission between sensors and the pseudo-time of flight (pToF) of the emission to the sensors...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156564/wireless-monitoring-of-induction-machine-rotor-physical-variables
#2
Jefferson Doolan Fernandes, Francisco Elvis Carvalho Souza, Glauco George Cipriano Maniçoba, Andrés Ortiz Salazar, José Alvaro de Paiva
With the widespread use of electric machines, there is a growing need to extract information from the machines to improve their control systems and maintenance management. The present work shows the development of an embedded system to perform the monitoring of the rotor physical variables of a squirrel cage induction motor. The system is comprised of: a circuit to acquire desirable rotor variable(s) and value(s) that send it to the computer; a rectifier and power storage circuit that converts an alternating current in a continuous current but also stores energy for a certain amount of time to wait for the motor's shutdown; and a magnetic generator that harvests energy from the rotating field to power the circuits mentioned above...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156509/the-role-of-exosomes-on-colorectal-cancer-a-review
#3
REVIEW
Lidia Ruiz-López, Isabel Blancas, José M Garrido, Nuria Mut-Salud, Marta Moya-Jódar, Antonio Osuna, Fernando Rodríguez-Serrano
Exosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly due to their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance and metastasis. The role of the exosomes in these processes involves the transfer of proteins, RNAs or mutant versions of proto-oncogenes to the target cells. In recent years, great efforts have been made to identify useful biomarkers in CRC exosomes for diagnosis, prediction of prognosis and treatment response...
November 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29156375/downregulation-of-the-protein-synthesis-machinery-is-a-major-regulatory-event-during-early-adipogenic-differentiation-of-human-adipose-derived-stromal-cells
#4
Bruna H Marcon, Fabíola B Holetz, Guillermo Eastman, Ana Carolina Origa-Alves, Mariana Andrea Amorós, Alessandra Melo de Aguiar, Carmen K Rebelatto, Paulo R S Brofman, Jose Sotelo-Silveira, Bruno Dallagiovanna
Commitment of adult stem cells involves the activation of specific gene networks regulated from transcription to protein synthesis. Here, we used ribosome profiling to identify mRNAs regulated at the translational level, through both differential association to polysomes and modulation of their translational rates. We observed that translational regulation during the differentiation of human adipose-derived stromal cells (hASCs, also known as adipose-derived mesenchymal stem cells), a subset of which are stem cells, to adipocytes was a major regulatory event...
November 1, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29156345/the-extended-production-of-uv-induced-reactive-oxygen-species-in-l929-fibroblasts-is-attenuated-by-posttreatment-with-arrabidaea-chica-through-scavenging-mechanisms
#5
Fabianne Martins Ribeiro, Hélito Volpato, Danielle Lazarin-Bidóia, Vânia Cristina Desoti, Rebeca Oliveira de Souza, Maria José Vieira Fonseca, Tânia Ueda-Nakamura, Celso Vataru Nakamura, Sueli de Oliveira Silva
Ultraviolet radiation (UVR) exposure causes various injurious effects to human skin by generating reactive oxygen species (ROS). Excessive ROS production can lead to oxidative stress which may damage cellular components like lipids and proteins and causing photoaging. The use of natural photochemopreventive agents with antioxidant properties is an important alternative to improve the effectiveness of sunscreens and reduce skin photodamage. A crude extract (CE) from the leaves of Arrabidaea chica underwent partition by a liquid-liquid method...
November 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29156344/neurotransmitter-changes-in-rat-brain-regions-following-glyphosate-exposure
#6
María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, María-Rosa Martínez-Larrañaga, Arturo Anadón
The effects of glyphosate oral exposure (35, 75, 150 and 800mg/kg bw, 6 days) on brain region monoamine levels of male Wistar rats were examined. Glyphosate-treated rats (35, 75, 150 and 800mg/kg bw, 6 days), had no visible injury, i.e., no clinical signs of dysfunction were observed. After last dose of glyphosate, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) and its metabolites levels were determined in the brain regions striatum, hippocampus, prefrontal, cortex, hypothalamus and midbrain, by HPLC...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29156294/phospholipase-a1-based-cross-reactivity-among-venoms-of-clinically-relevant-hymenoptera-from-neotropical-and-temperate-regions
#7
Amilcar Perez-Riverol, Luís Gustavo Romani Fernandes, Alexis Musacchio Lasa, José Roberto Aparecido Dos Santos-Pinto, Débora Moitinho Abram, Gabriel Hideki Izuka Moraes, Frederic Jabs, Michaela Miehe, Henning Seismman, Mario Sergio Palma, Ricardo de Lima Zollner, Edzard Spillner, Márcia Regina Brochetto-Braga
Molecular cross-reactivity caused by allergen homology or cross-reactive carbohydrate determinants (CCDs) is a major challenge for diagnosis and immunotherapy of insect venom allergy. Venom phospholipases A1 (PLA1s) are classical, mostly non-glycosylated wasp and ant allergens that provide diagnostic benefit for differentiation of genuine sensitizations from cross-reactivity. As CCD-free molecules, venom PLA1s are not causative for CCD-based cross-reactivity. Little is known however about the protein-based cross-reactivity of PLA1 within vespid species...
November 17, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29156232/use-of-negative-pressure-wound-therapy-after-infection-and-flap-dehiscence-in-radical-vulvectomy-a-case-report
#8
Antoni Llueca, Jose Luis Herraiz, Raquel Del Moral, Dolors Piquer, Yasmine Maazouzi, Blanca Segarra, Jordan Barres, Anna Serra
INTRODUCTION: Vulvar cancer has a lower incidence in high income countries, but is rising, in part, due to the high life expectancy in these societies. Radical vulvectomy is still the standard treatment in initial stages. Wound dehiscence contitututes one of the most common postoperative complications. PRESENTATION OF CASE: A 76year old patient with a squamous cell carcinoma of the vulva, FIGO staged, IIIb is presented. Radical vulvectomy and bilateral inguinal lymph node dissection with lotus petal flaps reconstruction are performed as the first treatment...
November 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29156226/frequency-of-brain-mri-abnormalities-in-neuromyelitis-optica-spectrum-disorder-at-presentation-a-cohort-of-latin-american-patients
#9
Edgar Carnero Contentti, Vanessa Daccach Marques, Ibis Soto de Castillo, Veronica Tkachuk, Amilton Antunes Barreira, Elizabeth Armas, Edson Chiganer, Camila de Aquino Cruz, José Luis Di Pace, Javier Pablo Hryb, Carolina Lavigne Moreira, Carmen Lessa, Omaira Molina, Monica Perassolo, Arnoldo Soto, Alejandro Caride
BACKGROUND: Brain magnetic resonance imaging (BMRI) lesions were classically not reported in neuromyelitis optica (NMO). However, BMRI lesions are not uncommon in NMO spectrum disorder (NMOSD) patients. OBJECTIVE: To report BMRI characteristic abnormalities (location and configuration) in NMOSD patients at presentation. METHODS: Medical records and BMRI characteristics of 79 patients with NMOSD (during the first documented attack) in Argentina, Brazil and Venezuela were reviewed retrospectively...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29156120/combining-fragment-ion-and-neutral-loss-matching-during-mass-spectral-library-searching-a-new-general-purpose-algorithm-applicable-to-illicit-drug-identification
#10
Arun Senthan Moorthy, William Edward Wallace, Anthony José Kearsley, Dmitrii V Tchekhovskoi, Stephen E Stein
A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single 'inert' structural component is described. This algorithm, the Hybrid Similarity Search, generates a similarity score based on matching both fragment ions and neutral losses. It employs the parameter DeltaMass, defined as the mass difference between query and library compounds, to shift neutral loss peaks in the library spectrum to match corresponding neutral loss peaks in the query spectrum. When the spectra being compared differ by a single structural feature, these matching neutral loss peaks should contain that structural feature...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29156023/2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease
#11
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29156017/early-and-late-outcomes-after-surgical-repair-of-congenital-supravalvular-aortic-stenosis-a-european-congenital-heart-surgeons-association-multicentric-study
#12
Massimo A Padalino, Anna Chiara Frigo, Marina Comisso, Martin Kostolny, Ikenna Omeje, Christian Schreiber, Jelena Pabst von Ohain, Julie Cleuziou, David J Barron, Bart Meyns, Viktor Hraska, Bohdan Maruszewski, Michal Kozlowski, Luca A Vricella, Narutoshi Hibino, Sarah Collica, Hakan Berggren, Mats Synnergren, Stojan Lazarov, David Kalfa, Emile Bacha, Christian Pizarro, Mark Hazekamp, Vlado Sojak, Jeffrey P Jacobs, Matej Nosal, Jose Fragata, Sertac Cicek, George E Sarris, Panayotis Zografos, Vladimiro L Vida, Giovanni Stellin
OBJECTIVES: Our goal was to evaluate the early and late results of the surgical management of congenital supravalvular aortic stenosis (SVAS). METHODS: We performed a retrospective, multicentre study using data from the European Congenital Heart Surgeons Association. Exclusion criteria were age >18 years, operation before 1990 and redo supravalvular aortic stenosis operations. Multivariate Cox regression analysis was performed to detect independent predictors of adverse events...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29156016/pectus-excavatum-repair-after-sternotomy-the-chest-wall-international-group-experience-with-substernal-nuss-bars
#13
Dawn E Jaroszewski, Paul J Gustin, Frank-Martin Haecker, Hans Pilegaard, Hyung Joo Park, Shao-Tao Tang, Shuai Li, Li Yang, Sadashige Uemura, Jose Ribas Milanez De Campos, Robert Obermeyer, Frazier W Frantz, Michele Torre, Lisa McMahon, Andre Hebra, Chih-Chun Chu, J Duncan Phillips, David M Notrica, Antonio Messineo, Robert Kelly, Mustafa Yüksel
OBJECTIVES: Patients with pectus excavatum (PE) after prior sternotomy for cardiac surgery present unique challenges for repair of PE. Open repairs have been recommended because of concerns about sternal adhesions and cardiac injury. We report a multi-institutional experience with repair utilizing substernal Nuss bars in this patient population. METHODS: Surgeons from the Chest Wall International Group were queried for experience and retrospective data on PE repair using sub-sternal Nuss bars in patients with a history of median sternotomy for cardiac surgery (November 2000 to August 2015)...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155921/aridification-as-a-driver-of-biodiversity-a-case-study-for-the-cycad-genus-dioon-zamiaceae
#14
José Said Gutiérrez-Ortega, Takashi Yamamoto, Andrew P Vovides, Miguel Angel Pérez-Farrera, José F Martínez, Francisco Molina-Freaner, Yasuyuki Watano, Tadashi Kajita
Background and Aims: Aridification is considered a selective pressure that might have influenced plant diversification. It is suggested that plants adapted to aridity diversified during the Miocene, an epoch of global aridification (≈15 million years ago). However, evidence supporting diversification being a direct response to aridity is scarce, and multidisciplinary evidence, besides just phylogenetic estimations, is necessary to support the idea that aridification has driven diversification...
November 16, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29155784/correlative-super-resolution-and-electron-microscopy-to-resolve-protein-localization-in-zebrafish-retina
#15
José M Mateos, Gery Barmettler, Jana Doehner, Irene Ojeda Naharros, Bruno Guhl, Stephan C F Neuhauss, Andres Kaech, Ruxandra Bachmann-Gagescu, Urs Ziegler
We present a method to investigate the subcellular protein localization in the larval zebrafish retina by combining super-resolution light microscopy and scanning electron microscopy. The sub-diffraction limit resolution capabilities of super-resolution light microscopes allow improving the accuracy of the correlated data. Briefly, 110 nanometer thick cryo-sections are transferred to a silicon wafer and, after immunofluorescence staining, are imaged by super-resolution light microscopy. Subsequently, the sections are preserved in methylcellulose and platinum shadowed prior to imaging in a scanning electron microscope (SEM)...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155678/joint-external-evaluation-development-and-scale-up-of-global-multisectoral-health-capacity-evaluation-process
#16
Elizabeth Bell, Jordan W Tappero, Kashef Ijaz, Maureen Bartee, Jose Fernandez, Hannah Burris, Karen Sliter, Simo Nikkari, Stella Chungong, Guenael Rodier, Hamid Jafari
The Joint External Evaluation (JEE), a consolidation of the World Health Organization (WHO) International Health Regulations 2005 (IHR 2005) Monitoring and Evaluation Framework and the Global Health Security Agenda country assessment tool, is an objective, voluntary, independent peer-to-peer multisectoral assessment of a country's health security preparedness and response capacity across 19 IHR technical areas. WHO approved the standardized JEE tool in February 2016. The JEE process is wholly transparent; countries request a JEE and are encouraged to make its findings public...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155667/use-of-a-diagonal-approach-to-health-system-strengthening-and-measles-elimination-after-a-large-nationwide-outbreak-in-mongolia
#17
José E Hagan, Ashley Greiner, Ulzii-Orshikh Luvsansharav, Jason Lake, Christopher Lee, Roberta Pastore, Yoshihiro Takashima, Amarzaya Sarankhuu, Sodbayar Demberelsuren, Rachel Smith, Benjamin Park, James L Goodson
Measles is a highly transmissible infectious disease that causes serious illness and death worldwide. Efforts to eliminate measles through achieving high immunization coverage, well-performing surveillance systems, and rapid and effective outbreak response mechanisms while strategically engaging and strengthening health systems have been termed a diagonal approach. In March 2015, a large nationwide measles epidemic occurred in Mongolia, 1 year after verification of measles elimination in this country. A multidisciplinary team conducted an outbreak investigation that included a broad health system assessment, organized around the Global Health Security Agenda framework of Prevent-Detect-Respond, to provide recommendations for evidence-based interventions to interrupt the epidemic and strengthen the overall health system to prevent future outbreaks of measles and other epidemic-prone infectious threats...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155538/aetiological-histopathological-clinical-diagnostic-and-therapeutical-features-of-idiopathic-cervical-resorption
#18
Virginia Robles Gijón, Cristina Lucena Martín, Rosa Mª Pulgar Encinas, José Manuel Navajas
Root resorption is the loss of hard dental tissue as a result of odontoclastic action involving vital and pulpless teeth. Cervical root resorption (CRR) is a type of external resorption which usually occurs immediately below the epithelial attachment of the tooth in the cervical region. The idiopathic cervical resorption (ICR) refers to a clinical situation in which all other causes, whether local or systemic, have been ruled out as the origin of the disease. The early stage is asymptomatic and might be diagnosed by a routine radiograph or a clinical examination...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29155283/comparative-analysis-of-media-effects-on-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-in-proarrhythmia-risk-assessment
#19
Derek Schocken, Jayna Stohlman, Jose Vicente, Dulciana Chan, Dakshesh Patel, Murali Krishna Matta, Vikram Patel, Mathew Brock, Daniel Millard, James Ross, David G Strauss, Ksenia Blinova
INTRODUCTION: Cardiotoxicity assessment using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) forms a key component of the Comprehensive in Vitro Proarrhythmia Assay (CiPA). A potentially impactful factor on iPSC-CM testing is the presence of serum in the experimental media. Generally, serum-free media is used to most accurately reproduce "free" drug concentration. However, caution is needed; drug solubility and cardiomyocyte electrophysiology could be affected by media formulation, potentially impacting interpretation of drug-induced effects...
November 16, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29155257/contrasting-the-microbiomes-from-forest-rhizosphere-and-deeper-bulk-soil-from-an-amazon-rainforest-reserve
#20
Jose Pedro Fonseca, Luisa Hoffmann, Bianca Catarina Azeredo Cabral, Victor Hugo Giordano Dias, Marcio Rodrigues Miranda, Allan Cezar de Azevedo Martins, Clarissa Boschiero, Wanderley Rodrigues Bastos, Rosane Silva
Pristine forest ecosystems provide a unique perspective for the study of plant-associated microbiota since they host a great microbial diversity. Although the Amazon forest is one of the hotspots of biodiversity around the world, few metagenomic studies described its microbial community diversity thus far. Understanding the environmental factors that can cause shifts in microbial profiles is key to improving soil health and biogeochemical cycles. Here we report a taxonomic and functional characterization of the microbiome from the rhizosphere of Brosimum guianense (Snakewood), a native tree, and bulk soil samples from a pristine Brazilian Amazon forest reserve (Cuniã), for the first time by the shotgun approach...
November 15, 2017: Gene
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