keyword
MENU ▼
Read by QxMD icon Read
search

jose

keyword
https://www.readbyqxmd.com/read/27926948/intrinsic-subtype-switching-and-acquired-erbb2-her2-amplifications-and-mutations-in-breast-cancer-brain-metastases
#1
Nolan Priedigkeit, Ryan J Hartmaier, Yijing Chen, Damir Vareslija, Ahmed Basudan, Rebecca J Watters, Roby Thomas, Jose P Leone, Peter C Lucas, Rohit Bhargava, Ronald L Hamilton, Juliann Chmielecki, Shannon L Puhalla, Nancy E Davidson, Steffi Oesterreich, Adam M Brufsky, Leonie Young, Adrian V Lee
Importance: Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies. Objective: To determine whether there are intrinsic subtype differences between primary tumors and matched BrM and to uncover BrM-acquired alterations that are clinically actionable. Design, Setting, and Participants: In total, 20 cases of primary breast cancer tissue and resected BrM (10 estrogen receptor [ER]-negative and 10 ER-positive) from 2 academic institutions were included...
December 7, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27926944/targeting-neutrophils-to-prevent-malaria-associated-acute-lung-injury-acute-respiratory-distress-syndrome-in-mice
#2
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R D' Império Lima, José M Alvarez, Silvia Portugal, Claudio R F Marinho, Sabrina Epiphanio
Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926786/nut-midline-carcinoma-of-the-larynx-an-international-series-and-review-of-the-literature
#3
Henrik Hellquist, Christopher A French, Justin A Bishop, Andrés Coca-Pelaz, Evan J Propst, António Paiva Correia, Bo-Yee Ngan, Ronald Grant, Nicole A Cipriani, David Vokes, Rui Henrique, Fernando Pardal, Jose Ramon Vizcaino, Alessandra Rinaldo, Alfio Ferlito
AIMS: NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that characteristically locates to the midline of the head and neck, and mediastinum. NMC is characterised by chromosomal rearrangements of the gene encoding nuclear protein in testis, NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion oncogene, BRD4-NUT. By the end of 2014, the International NUT Midline Carcinoma Registry had 48 patients treated for NMC. Laryngeal NMC are exceedingly rare and we report a case series of seven cases...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926738/corrigendum-mitochondrial-and-nuclear-dna-matching-shapes-metabolism-and-healthy-ageing
#4
Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fátima Sánchez-Cabo, Carlos Torroja, Rebeca Acín-Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan, María Luisa Bernad-Miana, Eduardo Romanos, Raquel Cruz, Sara Cogliati, Beatriz Sobrino, Ángel Carracedo, Acisclo Pérez-Martos, Patricio Fernández-Silva, Jesús Ruíz-Cabello, Michael P Murphy, Ignacio Flores, Jesús Vázquez, José Antonio Enríquez
No abstract text is available yet for this article.
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27926353/roles-of-body-image-related-experiential-avoidance-and-uncommitted-living-in-the-link-between-body-image-and-women-s-quality-of-life
#5
Inês A Trindade, Cláudia Ferreira, José Pinto-Gouveia
The current study aimed to test whether the associations of body mass index, body image discrepancy, and social comparison based on physical appearance with women's psychological quality of life (QoL) would be explained by the mechanisms of body image-related experiential avoidance and patterns of uncommitted living. The sample was collected from October 2014 to March 2015 and included 737 female college students (aged between 18 and 25 years) who completed validated self-report measures. Results demonstrated that the final path model explained 43% of psychological QoL and revealed an excellent fit...
December 7, 2016: Women & Health
https://www.readbyqxmd.com/read/27925855/costs-associated-with-influenza-related-hospitalization-in-the-elderly
#6
Núria Torner, Encarna Navas, Núria Soldevila, Diana Toledo, Gemma Navarro, Aurea Morillo, Maria José Pérez, Angela Domínguez
Seasonal influenza epidemics remain a considerable burden in adults, especially in those at higher risk of complications. The aim of this study was to determine the costs associated with influenza-related hospitalization in patients aged ≥65 years admitted to 20 hospitals from seven Spanish regions during the 2013-14 and 2014-15 influenza seasons. Bivariate analysis was used to compare costs in vaccinated and unvaccinated cases. Costs were calculated according to the Spanish National Health System diagnosis-related group tables for influenza and other respiratory system conditions (GRD 89 and GRD 101)...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925323/synthesis-binding-properties-and-differences-on-cell-uptake-of-g-quadruplex-ligands-based-on-carbohydrate-naphthalene-diimide-conjugates
#7
Matilde Arevalo, Filippo Doria, Efres Belmonte-Reche, Aurore De Rache, Jenny Campos-Salinas, Ricardo Lucas, Eva Falomir, Miguel Carda, Jose María Pérez-Victoria, Jean-Louis Mergny, Mauro Freccero, Juan Carlos Morales
G-quadruplex (G4) are currently being explored as therapeutic targets in cancer and other pathologies. We have synthesized six carbohydrate naphthalene diimide conjugates (carb-NDIs) as G4 ligands to investigate their potential selectivity on G4 binding and on cell penetration. Carb-NDIs have shown certain selectivity for G4 structures against DNA duplexes but the different sugar moieties did not induce a preference for a specific G4 topology. Interestingly, when monosaccharides were attached through a short ethylene linker to the NDI scaffold their cellular uptake was 2-3 fold more efficient than when the sugar was directly attached through its anomeric position...
December 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27925283/haloperidol-increases-false-recognition-memory-of-thematically-related-pictures-in-healthy-volunteers
#8
Regina V Guarnieri, Luciano G Buratto, Carlos F A Gomes, Rafaela L Ribeiro, Altay A Lino de Souza, Lilian M Stein, José C Galduróz, Orlando F A Bueno
Dopamine can modulate long-term episodic memory. Its potential role on the generation of false memories, however, is less well known. In a randomized, double-blind, placebo-controlled experiment, 24 young healthy volunteers ingested a 4-mg oral dose of haloperidol, a dopamine D2 -receptor antagonist, or placebo, before taking part in a recognition memory task. Haloperidol was active during both study and test phases of the experiment. Participants in the haloperidol group produced more false recognition responses than those in the placebo group, despite similar levels of correct recognition...
December 7, 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27925195/palmitoleic-acid-improves-metabolic-functions-in-fatty-liver-by-ppar%C3%AE-dependent-ampk-activation
#9
Camila O Souza, Alexandre A S Teixeira, Luana A Biondo, Edson A Lima, Helena A P Batatinha, Jose C Rosa Neto
BACKGROUND: Palmitoleic acid, since described as lipokine, increases glucose uptake by modulation of 5'AMP-activated protein kinase (AMPK), as well as increasing lipolysis by activation of peroxisome proliferator-activated receptor-α (PPARα), in adipose tissue. However in liver, the effects of palmitoleic acid on glucose metabolism and the role of PPARα remain unknown. OBJECTIVE: To investigate whether palmitoleic acid improved the hepatic insulin sensitivity of obese mice...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925190/s100a1-and-s100b-calcium-sensors-at-the-cross-roads-of-multiple-chondrogenic-pathways
#10
REVIEW
José Diaz-Romero, Dobrila Nesic
The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 + -activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human articular chondrocytes. Both proteins are homogeneously expressed in all cartilage zones, their expression decreases during chondrocyte dedifferentiation, and can be induced under conditions promoting redifferentiation...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925175/to-expand-coverage-or-increase-frequency-quantifying-the-tradeoffs-between-equity-and-efficiency-facing-cervical-cancer-screening-programs-in-low-resource-settings
#11
Nicole G Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura, Kyueun Lee, Jane J Kim
Cervical cancer is a leading cause of cancer death worldwide, with 85% of the disease burden residing in less developed regions. To inform evidence-based decision-making as cervical cancer screening programs are planned, implemented, and scaled in low- and middle-income countries, we used cost and test performance data from the START-UP demonstration project in Uganda and a microsimulation model of HPV infection and cervical carcinogenesis to quantify the health benefits, distributional equity, cost-effectiveness, and financial impact of either 1) improving access to cervical cancer screening or 2) increasing the number of lifetime screening opportunities for women who already have access...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27925129/-public-sector-participation-in-the-supply-of-dyslipidemia-medication-in-a-population-based-study
#12
Airton José Petris, Regina Kazue Tanno de Souza, Maira Sayuri Sakay Bortoletto
The use of medications for the treatment of dyslipidemia is relevant in the control of cardiovascular disease. This article aims to analyze the prevalence, the use and the participation of the public sector in the supply of medication for adults aged 40 years and above using pharmacotherapy for dyslipidemia control living in a city in the southern region of Brazil. A cross-sectional, population-based study was conducted. Household interviews were staged with 1180 individuals aged over 40 living in Cambé, State of Paraná, of which 967 took laboratory examinations...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925127/-user-evaluation-on-dental-care-in-the-unified-health-system-an-approach-from-the-standpoint-of-humanization
#13
Suzely Adas Saliba Moimaz, Arinilson Moreira Chaves Lima, Cléa Adas Saliba Garbin, José Eduardo Corrente, Nemre Adas Saliba
The scope of this study was to assess user evaluation about dental care in the Unified Health System and analyze the associations between this evaluation, sociodemographic characteristics, and aspects related to humanization of the services. It involved a cross-sectional survey with a quantitative approach, in which 461 users responded to individual interviews. The outcome variable was obtained by means of the question: "How do you consider the care given by the dentist and by the team in this health unit?" Responses were grouped into "positive evaluation" and "negative evaluation...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925121/review-of-deaths-correction-methods-and-quality-dimensions-of-the-underlying-cause-for-accidents-and-violence-in-brazil
#14
Adauto Martins Soares, Juan José Cortez-Escalante, Elisabeth França
This review article aims to perform analysis and critical discussion about the literature on methods correcting mortality from accidents and violence reported to the Brazilian Mortality Information System. We consulted Medline and SciELO databases, as well as the Global Burden of Disease site, using time filter for the 1996-2015 interval. Of the 77 studies identified, we selected 29, and 14 met the corrections production criteria for cases of underreporting: underreporting of deaths in the Mortality Information System, deaths declared as ill-defined causes or deaths from external causes declared with nonspecific codes...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925063/negative-serosurvey-of-toxoplasma-gondii-antibodies-in-golden-headed-lion-tamarin-leontopithecus-chrysomelas-from-niter%C3%A3-i-rj-brazil
#15
Camila Vieira Molina, Felipe da Silva Krawczak, Marina Galvão Bueno, Herbert Sousa Soares, Solange Maria Genari, Alcides Pissinatti, Maria Cecília Martins Kierulff, Tiago Ferreira da Silva, Danilo Gomes de Freitas, Larissa Cristinne Caneli, José Luiz Catão-Dias
New World Nonhuman Primates are highly susceptible to clinical toxoplasmosis. Serum samples from 126 recently captured Leontopithecus chrysomelas, from an exotic and invasive population, were tested for Toxoplasma gondii antibodies by the modified agglutination test (MAT, cut-off 1:25); all were seronegative. The MAT is highly specific and is not species-specific. This is the first report of T. gondii survey in this tamarin in the wild. This result is consistent with prior reports that showed the high susceptibility of the species to infection by T...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27925058/new-morphological-data-of-litomosoides-chagasfilhoi-nematoda-filarioidea-parasitizing-nectomys-squamipes-in-rio-de-janeiro-brazil
#16
Luís Cláudio Muniz-Pereira, Paula Araujo Gonçalves, Erick Vaz Guimarães, Fábio de Oliveira Fonseca, José Augusto Albuquerque Dos Santos, Arnaldo Maldonado-Júnior, Antonio Henrique Almeida de Moraes
Litomosoides chagasfilhoi, originally described by Moraes Neto, Lanfredi & De Souza (1997) parasitizing the abdominal cavity of the wild rodent, Akodon cursor (Winge, 1887), was found in the abdominal cavity of Nectomys squamipes (Brants, 1827), from the municipality of Rio Bonito, Rio de Janeiro State, Brazil. This study led to addition of new morphological data and a new geographical distribution for this filarioid in Brazil. Several characters were detailed and emended to previous records of L. chagasfilhoi in N...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27925047/a-pioneering-healthcare-model-applying-large-scale-production-concepts-principles-and-performance-after-more-than-11-000-transplants-at-hospital-do-rim
#17
José Medina Pestana
The kidney transplant program at Hospital do Rim (hrim) is a unique healthcare model that applies the same principles of repetition of processes used in industrial production. This model, devised by Frederick Taylor, is founded on principles of scientific management that involve planning, rational execution of work, and distribution of responsibilities. The expected result is increased efficiency, improvement of results and optimization of resources. This model, almost completely subsidized by the Unified Health System (SUS, in the Portuguese acronym), has been used at the hrim in more than 11,000 transplants over the last 18 years...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27925031/hourly-interaction-between-wind-speed-and-energy-fluxes-in-brazilian-wetlands-mato-grosso-brazil
#18
Thiago R Rodrigues, Leone F A Curado, Vinicius M R Pereira, Luciana Sanches, José S Nogueira
Matter and energy flux dynamics of wetlands are important to understand environmental processes that govern biosphere-atmosphere interactions across ecosystems. This study presents analyses about hourly interaction between wind speed and energy fluxes in Brazilian Wetlands - Mato Grosso - Brazil. This study was conducted in Private Reserve of Natural Heritage (PRNH SESC, 16º39'50''S; 56º47'50''W) in Brazilian Wetland. According to Curado et al. (2012), the wet season occurs between the months of January and April, while the June to September time period is the dry season...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27924801/scrotum-melanoma-evolution-over-one-year-in-this-unusual-location
#19
Leopoldo José Marzullo Zucchet, Miguel Ángel Bonillo García, Laura Lorenzo Soriano, Enrique Broseta Rico
Genitourinary melanoma accounts for 0.1-0.2% of melanoma, the scrotum being its rarest location. We report about an 85-year-old patient who was referred to our outpatient clinic due to the presence of a scrotum black papule for 20 months. Wide local excision was performed, and histology revealed a malignant melanoma. Chest and abdominal CT revealed metastatic disease, so chemotherapy, immunotherapy and radiotherapy were administered. We describe the evolution over 1 year in this unusual location, as well as complications and the currently available therapeutic options to cure this disease...
December 8, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27924760/p-wave-dispersion-an-update
#20
REVIEW
Andrés Ricardo Pérez-Riera, Luiz Carlos de Abreu, Raimundo Barbosa-Barros, José Grindler, Acácio Fernandes-Cardoso, Adrian Baranchuk
P-wave dispersion (PWD, Pd or Pdis) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and predictor for atrial fibrillation (AF). PWD is defined as the difference between the widest and the narrowest P-wave duration recorded from the 12 ECG leads. Increased P-wave duration and PWD reflect prolongation of intraatrial and interatrial conduction time with lack of a well-coordinated conduction system within the atrial muscles, with inhomogeneous, asynchronic, pro-inflammatory and anti-inflammatory effect mediated by interleukin-6 (IL-6) in patients with the CG + GG genotype IL-6 -634C/G polymorphism [1] and discontinuous propagation of sinus impulses mainly between the left and right atria, interstitial/extracellular fibroblast activation and collagen deposition with fibrosis (via TGF-β) in atrial tissue, insufficient blood supply, significant not isotropic myoelectric activity, and thin wall thickness and consequent expansion tendency all well-known electrophysiological characteristics in patients with atrial arrhythmias and especially paroxysmal atrial fibrillation (PAF) [2]...
July 2016: Indian Pacing and Electrophysiology Journal
keyword
keyword
85912
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"