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https://www.readbyqxmd.com/read/29769252/frequency-of-non-motor-symptoms-in-parkinson-s-disease-presenting-to-tertiary-care-centre-in-pakistan-an-observational-cross-sectional-study
#1
Shahid Mukhtar, Rashid Imran, Mohsin Zaheer, Huma Tariq
OBJECTIVE: To determine the frequency of non-motor symptoms (NMS) in patients of Parkinson's disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients. STUDY DESIGN: Observational, cross-sectional study. SETTING: Tertiary care centre. PARTICIPANTS: Out of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29766459/cognitive-functioning-in-chiari-malformation-type-i-without-posterior-fossa-surgery
#2
Maitane García, Esther Lázaro, Juan Francisco López-Paz, Oscar Martínez, Manuel Pérez, Sarah Berrocoso, Mohammad Al-Rashaida, Imanol Amayra
Chiari Malformation type I (CM-I) is a neurological disorder characterized by a displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Most research has focused on physical symptomatology but few studies include neuropsychological examinations. Moreover, although current research highlights the involvement of the cerebellum on higher cognitive functions, little is known about cognitive consequences associated with CM-I. The aim of this study is to analyze cognitive functioning between 39 CM-I patients and 39 healthy controls, matched by gender, age and years of education...
May 15, 2018: Cerebellum
https://www.readbyqxmd.com/read/29764970/reinforcement-signaling-of-punishment-versus-relief-in-fruit-flies
#3
Christian König, Afshin Khalili, Mathangi Ganesan, Amrita P Nishu, Alejandra P Garza, Thomas Niewalda, Bertram Gerber, Yoshinori Aso, Ayse Yarali
Painful events establish opponent memories: cues that precede pain are remembered negatively, whereas cues that follow pain, thus coinciding with relief are recalled positively. How do individual reinforcement-signaling neurons contribute to this "timing-dependent valence-reversal?" We addressed this question using an optogenetic approach in the fruit fly. Two types of fly dopaminergic neuron, each comprising just one paired cell, indeed established learned avoidance of odors that preceded their photostimulation during training, and learned approach to odors that followed the photostimulation...
June 2018: Learning & Memory
https://www.readbyqxmd.com/read/29753752/the-cingulum-bundle-anatomy-function-and-dysfunction
#4
REVIEW
Emma J Bubb, Claudia Metzler-Baddeley, John P Aggleton
The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its apparent continuity, the cingulum's composition continually changes as fibres join and leave the bundle. To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle. Next, the impact of cingulum bundle damage in rats, monkeys, and humans is analysed...
May 10, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29747622/postoperative-dental-morbidity-in-children-following-dental-treatment-under-general-anesthesia
#5
Yu-Hsuan Hu, Aileen Tsai, Li-Wei Ou-Yang, Li-Chuan Chuang, Pei-Ching Chang
BACKGROUND: General anesthesia has been widely used in pediatric dentistry in recent years. However, there remain concerns about potential postoperative dental morbidity. The goal of this study was to identify the frequency of postoperative dental morbidity and factors associated with such morbidity in children. METHODS: From March 2012 to February 2013, physically and mentally healthy children receiving dental treatment under general anesthesia at the Department of Pediatric Dentistry of the Chang Gung Memorial Hospital in Taiwan were recruited...
May 10, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29745732/tattered-textures-of-kinship-the-effects-of-torture-among-iraqi-families-in-denmark
#6
Lotte Buch Segal
Drawing on ethnographic fieldwork in Denmark, primarily among Iraqi women and secondarily among Iraqi men who are either direct or indirect victims of torture, I explore how the memories of torture are distributed in the everyday lives of Danish families originating from Iraq. I argue that torture is folded into kin histories and the everyday work of bearing and resisting painful memories. Consequently, torture affects not only the mental and physical health of the singular survivor, but also the entire texture of kin relatedness around him or her, to the extent that kinship normativity may be disrupted...
May 10, 2018: Medical Anthropology
https://www.readbyqxmd.com/read/29741590/rate-of-muscle-contraction-is-associated-with-cognition-in-women-not-in-men
#7
Qu Tian, Yusuke Osawa, Susan M Resnick, Luigi Ferrucci, Stephanie A Studenski
Background: In older persons, lower hand grip strength is associated with poorer cognition. Little is known about how the rate of muscle contraction relates to cognition and upper extremity motor function, and sex differences are understudied. Methods: Linear regression, adjusting for age, race, education, body mass index, appendicular lean mass, and knee pain assessed sex-specific cross-sectional associations of peak torque, rate of torque development (RTD) and rate of velocity development (RVD) with cognition and upper extremity motor function...
May 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29739433/-because-if-we-talk-about-health-issues-first-it-is-easier-to-talk-about-human-trafficking-findings-from-a-mixed-methods-study-on-health-needs-and-service-provision-among-migrant-and-trafficked-fishermen-in-the-mekong
#8
Nicola S Pocock, Reena Tadee, Kanokwan Tharawan, Wansiri Rongrongmuang, Brett Dickson, Soksreymom Suos, Ligia Kiss, Cathy Zimmerman
BACKGROUND: Human trafficking in the fishing industry or "sea slavery" in the Greater Mekong Subregion is reported to involve some of the most extreme forms of exploitation and abuse. A largely unregulated sector, commercial fishing boats operate in international waters far from shore and outside of national jurisdiction, where workers are commonly subjected to life-threatening risks. Yet, research on the health needs of trafficked fishermen is sparse. This paper describes abuses, occupational hazards, physical and mental health and post-trafficking well-being among a systematic consecutive sample of 275 trafficked fishermen using post-trafficking services in Thailand and Cambodia...
May 9, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29738554/repeated-mild-traumatic-brain-injury-can-cause-acute-neurologic-impairment-without-overt-structural-damage-in-juvenile-rats
#9
Alicia Meconi, Ryan C Wortman, David K Wright, Katie J Neale, Melissa Clarkson, Sandy R Shultz, Brian R Christie
Repeated concussion is becoming increasingly recognized as a serious public health concern around the world. Moreover, there is a greater awareness amongst health professionals of the potential for repeated pediatric concussions to detrimentally alter the structure and function of the developing brain. To better study this issue, we developed an awake closed head injury (ACHI) model that enabled repeated concussions to be performed reliably and reproducibly in juvenile rats. A neurological assessment protocol (NAP) score was generated immediately after each ACHI to help quantify the cumulative effects of repeated injury on level of consciousness, and basic motor and reflexive capacity...
2018: PloS One
https://www.readbyqxmd.com/read/29735513/a-unifying-theory-for-cognitive-abnormalities-in-functional-neurological-disorders-fibromyalgia-and-chronic-fatigue-syndrome-systematic-review
#10
REVIEW
Tiago Teodoro, Mark J Edwards, Jeremy D Isaacs
BACKGROUND: Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD. METHODS: We conducted a systematic review of studies with cognition-related outcomes in FM, CFS and FND...
May 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29720346/tako-tsubo-cardiomyopathy-with-transient-global-amnesia-and-cerebellar-embolic-stroke-triggered-by-existential-fear
#11
Claudia Stöllberger, Nicolas DeCillia, Josef Finsterer
BACKGROUND: Embolic stroke is a complication of Tako-Tsubo-cardiomyopathy (TTC), transient left ventricular dysfunction mimicking myocardial infarction without coronary culprit lesion explaining the whole left ventricular dysfunction. Transient global amnesia (TGA) is characterized by sudden onset of anterograde amnesia without compromise of other neurologic functions. CASE REPORT: A 57 years old female was admitted because of sudden confusion and loss of her memory after emotional stress...
January 6, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29701033/-identification-of-mouse-brain-neuropeptides-by-high-throughput-mass-spectrometry
#12
Xianfeng Shao, Min Ma, Ruibing Chen, Chenxi Jia
Neuropeptides play an important role in the physiological functions of the human body. The physiological activities such as pain, sleep, mood, learning and memory are affected by neuropeptides. Neuropeptides mainly exist in the nerve tissue of the body, and a small amount of them are distributed in body fluid and organs. At present, analysis of large-scale identification of neuropeptides in whole brain tissue is still challenging. Therefore, high-throughput detection of these neuropeptides is greatly significant to understand the composition and function of neuropeptides...
April 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29698249/memories-of-infant-pain-in-the-neonatal-intensive-care-unit-influence-posttraumatic-stress-symptoms-in-mothers-of-infants-born-preterm
#13
Jillian Vinall, Melanie Noel, Timothy Disher, Kim Caddell, Marsha Campbell-Yeo
OBJECTIVES: The birth of a preterm infant and witnessing ones' infant in pain is remembered by parents as being one of the most stressful aspects of the neonatal care intensive unit (NICU). Elevated symptoms of posttraumatic stress symptoms (PTSS) are highly prevalent among mothers of preterm infants, however, little is known about mothers' memories of invasive procedures in the NICU and how these memories may contribute to the development of PTSS. We examined the relationships between number of invasive procedures, mothers' memories of these procedures, and their PTSS at discharge from the NICU...
April 25, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29696166/design-rationale-and-feasibility-of-a-multidimensional-experimental-protocol-to-study-early-life-stress
#14
M Dillwyn Bartholomeusz, Philip S Bolton, Robin Callister, Virginia Skinner, Deborah Hodgson
There is a rapidly accumulating body of evidence regarding the influential role of early life stress (ELS) upon medical and psychiatric conditions. While self-report instruments, with their intrinsic limitations of recall, remain the primary means of detecting ELS in humans, biological measures are generally limited to a single biological system. This paper describes the design, rationale and feasibility of a study to simultaneously measure neuroendocrine, immune and autonomic nervous system (ANS) responses to psychological and physiological stressors in relation to ELS...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695262/hypericum-perforatum-to-improve-post-operative-pain-outcome-after-monosegmental-spinal-microdiscectomy-hypos-a-study-protocol-for-a-randomised-double-blind-placebo-controlled-trial
#15
Christa Raak, Wolfram Scharbrodt, Bettina Berger, Arndt Büssing, René Geißen, Thomas Ostermann
BACKGROUND: Spinal disc herniation is a frequently occurring degenerative disease of the spine. Many patients undergoing surgery suffer from radicular pain, known as memory pain, beginning from the third post-operative day. This results in the prescription of high-dose opioid medications. In homeopathy, Hypericum perforatum is known as a remedy for unbearable, shooting or jabbing pain especially when neural damage is involved. Reduction of pain after application of H. perforatum has been observed in previous studies...
April 25, 2018: Trials
https://www.readbyqxmd.com/read/29694662/technique-of-localizing-the-central-sulcus-under-awaking-anesthesia-for-treatmeat-of-gliomas-in-or-near-motor-areas
#16
Wan Yi, Shujun Xu, Xingang Li, Xiangyu Ma
AIM: This study aimed to study the protective effect of intraoperative awakening and central sulcus location on motor function for patients with gliomas located in motor areas. METHODS: A total of 68 patients with gliomas in motor areas were intubated with a laryngeal mask and rapidly underwent craniotomy without scalp clips and awakening, followed by localization of the central sulcus by somatosensory evoked potential. To protect brain function, we resected the greatest degree of tumor as possible and then finished the close-skull under an awakened state or general anesthesia...
April 6, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29694417/executive-function-impairments-in-fibromyalgia-syndrome-relevance-of-clinical-variables-and-body-mass-index
#17
Cristina Muñoz Ladrón de Guevara, María José Fernández-Serrano, Gustavo A Reyes Del Paso, Stefan Duschek
BACKGROUND: Several investigations suggest the presence of deterioration of executive function in fibromyalgia syndrome (FMS). The study quantified executive functions in patients with FMS. A wide array of functions was assessed, including updating, shifting and inhibition, as well as decision making and mental planning. Moreover, clinical variables were investigated as possible mediators of executive dysfunction, including pain severity, psychiatric comorbidity, medication and body mass index (BMI)...
2018: PloS One
https://www.readbyqxmd.com/read/29674992/memory-modulation-self-improvement-or-self-depletion
#18
Andrea Lavazza
Autobiographical memory is fundamental to the process of self-construction. Therefore, the possibility of modifying autobiographical memories, in particular with memory-modulation and memory-erasing, is a very important topic both from the theoretical and from the practical point of view. The aim of this paper is to illustrate the state of the art of some of the most promising areas of memory-modulation and memory-erasing, considering how they can affect the self and the overall balance of the "self and autobiographical memory" system...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29673669/rupture-of-the-scarred-and-unscarred-gravid-uterus-outcomes-and-risk-factors-analysis
#19
Shu-Han You, Yao-Lung Chang, Chih-Feng Yen
OBJECTIVE: To study the maternal and fetal outcomes and assess the risk factors in patients with rupture at the lower-segment or non-lower-segment scarred, or unscarred gravid uterus. MATERIALS AND METHODS: Gravid patients with uterine rupture were retrospectively collected in Chang-Gung Memorial Hospital from November 2004 to July 2017. The rupture timing and location in association with maternal and fetal outcomes were collected as well as the possible risk factors including surgical history and interval prior to conception were analyzed...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29667130/beneficial-effects-of-the-calcium-channel-blocker-ctk-01512-2-in-a-mouse-model-of-multiple-sclerosis
#20
Rodrigo B M Silva, Samuel Greggio, Gianina T Venturin, Jaderson C da Costa, Marcus V Gomez, Maria M Campos
Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of this molecule in the mouse model of experimental autoimmune encephalomyelitis (EAE). The effects of CTK 01512-2 were compared to those displayed by ziconotide-a selective N-type VGCC blocker clinically used for chronic pain-and fingolimod-a drug employed for MS treatment...
April 17, 2018: Molecular Neurobiology
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