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https://www.readbyqxmd.com/read/29341465/p2y12-deficiency-in-mouse-impairs-noradrenergic-system-in-brain-and-alters-anxiety-like-neurobehavior-and-memory
#1
Fang Zheng, Qiang Zhou, Yin Cao, Hailian Shi, Hui Wu, Beibei Zhang, Fei Huang, Xiaojun Wu
Purinergic receptor P2Y12 (P2Y12 ), a G protein-coupled (GPCR) purinergic receptor, is widely distributed in nervous system and involved in the progression of neurological diseases such as multiple sclerosis and neuropathic pain. The central noradrenergic system actively participates in a number of neurophysiological processes. Nevertheless, whether there is any direct relevance between P2Y12 and noradrenergic signal transduction remains unknown. In the present study, we tested the hypothesis that lack of P2Y12 impaired noradrenergic signal transduction in mouse brain...
January 17, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29340966/cannabinomimetric-lipids-from-natural-extract-to-artificial-synthesis
#2
REVIEW
Ya-Ru Gao, Yong-Qiang Wang
Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2. Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors...
January 16, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29338150/the-role-of-cannabinoids-in-pain-control-the-good-the-bad-and-the-ugly
#3
Joseph V Pergolizzi, Jo Ann Lequang, Robert Taylor, Robert B Raffa, Daniel Colucci
Cannabinoids appear to possess many potential medical uses, which may extend to pain control. A narrative review of the literature has found a variety of studies testing botanical and synthetic cannabinoids in different pain syndromes (acute pain, cancer pain, chronic noncancer pain, fibromyalgia pain, migraine, neuropathic pain, visceral pain, and others). Results from these studies are mixed; cannabinoids appear to be most effective in controlling neuropathic pain, allodynia, medication-rebound headache, and chronic noncancer pain, but do not seem to offer any advantage over nonopioid analgesics for acute pain...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29332033/effect-of-dual-tasking-on-anticipatory-and-compensatory-postural-adjustments-in-response-to-external-perturbations-in-individuals-with-nonspecific-chronic-low-back-pain-electromyographic-analysis
#4
Ladan Hemmati, Soraya Piroozi, Zahra Rojhani-Shirazi
BACKGROUND: In patients with chronic low back pain (CLBP), postural control is a demanding task in terms of attention. Although the attentional demands of postural control have been investigated in these patients, the attentional demands of postural recovery during dual task performance have not been evaluated in patients with nonspecific CLBP. OBJECTIVE: To investigate the effect of dual tasking on anticipatory and compensatory postural adjustments in response to an external perturbation in patients with nonspecific CLBP...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29318865/-advances-in-acupuncture-mechanism-research-on-the-changes-of-synaptic-plasticity-pain-memory-for-chronic-pain
#5
Yi-Ling Yang, Jian-Peng Huang, Li Jiang, Jian-Hua Liu
Previous studies have shown that there are many common structures between the neural network of pain and memory, and the main structure in the pain network is also part of the memory network. Chronic pain is characterized by recurrent attacks and is associated with persistent ectopic impulse, which causes changes in synaptic structure and function based on nerve activity. These changes may induce long-term potentiation of synaptic transmission, and ultimately lead to changes in the central nervous system to produce "pain memory"...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29317063/trigeminal-long-term-potentiation-as-a-cellular-substrate-for-migraine
#6
Dong-Ho Youn
Most previous studies suggest that the subnucleus caudalis (Vc) of spinal trigeminal nucleus (Vsp) plays a key role in the generation and maintenance of migraine, a type of primary headache, by participating in the trigeminovascular system. Furthermore, the excitability of the Vc with the stimulation of the peripheral nociceptive fibers innervating the intracranial vessels or dura matter is regarded as a main cellular substrate for migraine. Here, a revised hypothesis is introduced, reinforcing the previous hypothesis and complementing it...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315955/prevalence-of-physical-problems-detected-by-the-distress-thermometer-and-problem-list-in-patients-with-breast-cancer
#7
Daniel C McFarland, Kelly M Shaffer, Amy Tiersten, Jimmie Holland
BACKGROUND: Patients with breast cancer have high rates of physical symptoms that negatively impact their quality of life. The relationship between women's perceptions of these physical symptoms and patient demographic and breast cancer characteristics is less well known. This study describes breast cancer patients' physical symptoms and their relationship with patient characteristics. METHODS: Patients (n=125) with breast cancer (Stage 0-IV) completed questionnaires in a dedicated academic medical center breast cancer clinic...
January 5, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29310453/the-relationship-between-sleep-quality-and-fibromyalgia-symptoms
#8
Alexandro Andrade, Guilherme Torres Vilarino, Sofia Mendes Sieczkowska, Danilo Reis Coimbra, Guilherme Guimarães Bevilacqua, Ricardo de Azevedo Klumb Steffens
This study investigated the relationship between sleep quality and fibromyalgia symptoms in 326 patients. The Pittsburgh Sleep Quality Index was used to assess the presence of sleep disorders. Multivariate analysis of variance was performed to determine the influence of fibromyalgia symptoms on sleep quality. The prevalence of sleep disorders was 92.9 percent. Patients reported generalized pain (88.3%), memory failure (78.5%), moodiness (59%), excessive anxiety (77.5%), and concentration difficulties (69...
January 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29305318/behavioral-phenotyping-of-calcium-channel-cacn-subunit-%C3%AE-2%C3%AE-3-knockout-mice-consequences-of-sensory-cross-modal-activation
#9
Julia Landmann, Franziska Richter, Joseph Classen, Angelika Richter, Josef M Penninger, Ingo Bechmann
Sensory cross-activation is still ill-defined and research concerning the consequences of sensory mergence on normal brain function is very limited. Human studies describe behavioral benefits of people with synesthesia- a peculiar form of perception possibly due to cross-modal activation- regarding sensory and memory abilities. Here, we studied behavioral alterations in calcium channel (CACN) subunit α2δ3 knockout (KO) mice exhibiting pain-induced cortical cross-modal activation. Knockout mice exhibited an increased response upon touch of a pinna and impaired audition, while elementary olfaction, vision, somatosensation and motor function were not altered...
January 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29303789/sevoflurane-blocks-the-induction-of-long-term-potentiation-when-present-during-but-not-when-present-only-before-the-high-frequency-stimulation
#10
Jinyang Liu, Lie Yang, Daisy Lin, James E Cottrell, Ira S Kass
BACKGROUND: This study tests the hypothesis that sevoflurane blocks long-term potentiation only if it is present during the high-frequency stimulation that induces long-term potentiation. METHODS: Long-term potentiation, an electrophysiologic correlate of memory, was induced by high-frequency stimulation and measured as a persistent increase in the field excitatory postsynaptic potential slope in the CA1 region. RESULTS: Long-term potentiation was induced in the no sevoflurane group (171 ± 58% vs...
January 5, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29285444/optimal-levothyroxine-replacement-adequately-improves-symptoms-of-hypothyroidism-residual-symptoms-need-further-evaluation-for-other-than-hypothyroidism-causation
#11
Rekha Singh, Ashwani Tandon, Sushil Kumar Gupta, K Saroja
Objectives: Many patients with hypothyroidism complain of persistent residual symptoms, despite optimal treatment, although the similar prevalence is seen in patients with documented absence of thyroid disorder in primary health-care setup. We aimed to investigate symptomatic relief in new cases of primary hypothyroidism and compare with controls with other chronic conditions. Methods: This prospective case-control follow-up study enrolled patients from July 2014 to May 2015 in an endocrine outpatient clinic of a tertiary hospital...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29284277/-life-within-the-person-comes-to-the-fore-pastoral-workers-practice-wisdom-on-using-arts-in-palliative-care
#12
Clare O'Callaghan, Libby Byrne, Eleni Cokalis, David Glenister, Margaret Santilli, Rose Clark, Therese McCarthy, Natasha Michael
BACKGROUND: Pastoral care (also chaplaincy, spiritual care) assists people to find meaning, personal resources, and connection with self, others, and/or a higher power. Although essential in palliative care, there remains limited examination of what pastoral workers do. This study examined how pastoral workers use and consider the usefulness of art-based modalities. METHODS: Qualitative research was used to examine the practice wisdom (tacit practice knowledge) of pastoral workers experienced in using visual arts and music in palliative care...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29282342/-motor-symptoms-of-autoimmune-encephalopathies
#13
Yuichi Tashiro, Hiroshi Takashima
Autoimmune encephalopathies are clinically and immunologically heterogeneous disorders. At least 20 types of autoimmune encephalopathies have been discovered, with the most common type being Hashimoto encephalopathy. In clinical situations, we often observe that patients with autoimmune encephalopathy are misdiagnosed because they exhibit signs similar to those observed in functional psychogenic movement, conversion, or somatoform disorders. We clinically examined over 100 patients with autoimmune encephalopathy...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29249203/characterization-of-excitatory-synaptic-transmission-in-the-anterior-cingulate-cortex-of-adult-tree-shrew
#14
Xu-Hui Li, Qian Song, Qi-Yu Chen, Jing-Shan Lu, Tao Chen, Min Zhuo
The tree shrew, as a primate-like animal model, has been used for studying high brain functions such as social emotion and spatial learning memory. However, little is known about the excitatory synaptic transmission in cortical brain areas of the tree shrew. In the present study, we have characterized the excitatory synaptic transmission and intrinsic properties of pyramidal neurons in the anterior cingulate cortex (ACC) of the adult tree shrew, a key cortical region for pain perception and emotion. We found that glutamate is the major excitatory transmitter for fast synaptic transmission...
December 18, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29242136/anxiolytic-effect-of-cpeb1-knockdown-on-the-amygdala-of-a-mouse-model-of-inflammatory-pain
#15
Jiao Yue, Xin-Shang Wang, Yan-Yan Guo, Kai-Yin Zheng, Hai-Yan Liu, Li-Ning Hu, Ming-Gao Zhao, Shui-Bing Liu
Anxiety disorders are a category of mental disorders characterized by feelings of anxiety, stress, and fear attached to various sources. However, their pathogenesis is complicated and has not been fully elucidated. The amygdala is a vital brain region that regulates anxiety and mental disorders. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the extension of the mRNA polyadenylation tail and facilitates the translation of target RNA. CPEB1 is closely related to neuronal diseases, such as Fragile X Syndrome, learning and memory disorders, and chronic pain...
December 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29239060/prevalence-and-predictors-of-depression-pain-and-fatigue-in-older-versus-younger-adult-cancer-survivors
#16
Lisa A Bevilacqua, Deirdre Dulak, Elizabeth Schofield, Tatiana D Starr, Christian J Nelson, Andrew J Roth, Jimmie C Holland, Yesne Alici
BACKGROUND: As the number of older adults in the United States continues to grow, there will be increasing demands on health care providers to address the needs of this population. Cancer is of particular importance, with over half of all cancer survivors over age 65. In addition, depression, pain, and fatigue are concerns for older adults with cancer and have been linked to poorer physical outcomes. METHODS: For this retrospective chart review, 1012 eligible participants were identified via a query of the Electronic Medical Record for all patients referred to one of four Survivorship Clinics at Memorial Sloan Kettering Cancer Center...
December 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29232539/how-to-identify-and-manage-cognitive-dysfunction-after-breast-cancer-treatment
#17
Marie Lange, Florence Joly
Attention and memory dysfunction is a common complaint among patients with breast cancer that can be reported during and up to several years after treatment. It can negatively affect patients' quality of life and their ability to work. This phenomenon has mainly been studied in patients with breast cancer who are treated with adjuvant chemotherapy. Women describe concentration problems and difficulties with word finding, multitasking, or remembering new information, as well as more effort and time needed to accomplish these tasks...
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29231597/-clinical-experience-of-acupuncture-and-moxibustion-in-the-diagnosis-and-treatment-of-persistent-somatoform-pain-disorder
#18
Jing Sun, Yi Liang, Chao Wang, Xiaomei Shao, Jianqiao Fang
The clinical manifestation and clinical diagnosis and treatment of acupuncture for persistent somatoform pain disorder (PSPD) were observed to explore its etiology. It is found that the causative factor of PSPD is probably relevant with pain memory induced by the negative emotions during the first attack of pain, which is in the category of "depression" in TCM. In clinical diagnosis, the medical history should be explored to discover the potential etiology and determine the diagnosis. In treatment, the root cause should be considered, focusing on mind and qi regulation and associating with analgesia...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227505/neurobiology-of-sexual-assault-and-osteopathic-considerations-for-trauma-informed-care-and-practice
#19
Kristen M Cuevas, Jane Balbo, Krista Duval, Elizabeth A Beverly
Sexual assault is a traumatic event with potentially devastating lifelong effects on physical and emotional health. Sexual assault is associated with gastrointestinal, neurologic, and reproductive symptoms, as well as obesity, diabetes, and chronic pain. With 1 in 3 women and 1 in 6 men experiencing some form of unwanted sexual violence in their lifetime, sexual assault is a significant public health problem that necessitates attention in the medical community. This review discusses relevant literature on the neurobiologic changes that occur as a consequence of sexual assault, such as how the brain responds during a traumatic experience and the impact of trauma on memory...
December 11, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29226495/forgetting-to-remember-prospective-memory-within-the-context-of-pain
#20
R Gatzounis, M G S Schrooten, G Crombez, J W S Vlaeyen
BACKGROUND: Pain interferes with cognitive functioning in several ways. Among other symptoms, pain patients often report difficulties with remembering future intentions. It remains unclear, however, whether it is the pain per se that impairs prospective remembering or other factors that often characterize people with pain (e.g. poor sleep quality). In this experiment, we investigated whether prospective memory is impaired within the context of pain, and whether this impairment is enhanced when the threat value of pain is increased...
December 11, 2017: European Journal of Pain: EJP
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