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Painful memory

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https://www.readbyqxmd.com/read/28108332/sex-dependent-effects-of-early-life-inflammatory-pain-on-sucrose-intake-and-sucrose-associated-hippocampal-arc-expression-in-adult-rats
#1
Yoko O Henderson, Rebecca Nalloor, Almira Vazdarjanova, Anne Z Murphy, Marise B Parent
We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory of a meal and inhibit the initiation of the next meal and the amount ingested during that meal. In support, we showed previously that (1) consuming a sucrose meal induces expression of the synaptic plasticity marker activity-regulated cytoskeleton-associated protein (Arc) in dHC neurons and (2) reversible inactivation of these neurons immediately following a sucrose meal accelerates the onset of the next meal and increases the size of that meal...
January 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#2
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28103477/a-brief-history-of-long-term-potentiation
#3
REVIEW
Roger A Nicoll
Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been published on this intriguing phenomenon, which provides a compelling cellular model for learning and memory. Although LTP has suffered considerable growing pains over the years, LTP has finally come of age. Here the rich history of LTP is reviewed. These are exciting times and the pace of discovery is remarkable.
January 18, 2017: Neuron
https://www.readbyqxmd.com/read/28100530/feasibility-of-measuring-memory-response-to-increasing-dexmedetomidine-sedation-in-children
#4
K P Mason, E R Kelhoffer, R Prescilla, M Mehta, J C Root, V J Young, F Robinson, R A Veselis
BACKGROUND: The memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to the onset of sedation. METHODS: A 10 min bolus of dexmedetomidine (2 mcg kg(-1)) was given to children as they named simple line drawings every five s...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28098721/the-endocannabinoid-system-and-its-role-in-eczematous-dermatoses
#5
Alexandra R Trusler, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Disruption of ECS homeostasis is implicated in the pathogenesis of several prevalent skin conditions...
January 2017: Dermatitis
https://www.readbyqxmd.com/read/28096256/chronic-symptoms-in-a-representative-sample-of-community-dwelling-older-people-a-cross-sectional-study-in-switzerland
#6
Yves Henchoz, Christophe Büla, Idris Guessous, Nicolas Rodondi, René Goy, Maurice Demont, Brigitte Santos-Eggimann
OBJECTIVES: The burden of multiple diagnoses is well documented in older people, but less is known about chronic symptoms, many of which are even not brought to medical attention. This study aimed to determine the prevalence of chronic symptoms, their relationships with disability in basic activities of daily living (BADL) and quality of life (QoL), and their public health impact. DESIGN: A large cross-sectional population-based study. SETTING: Community in 2 regions of French-speaking Switzerland...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28093211/pharmacological-properties-of-sak3-a-novel-t-type-voltage-gated-ca-2-channel-enhancer
#7
Yasushi Yabuki, Kazuya Matsuo, Hisanao Izumi, Hidaka Haga, Takashi Yoshida, Minoru Wakamori, Akira Kakehi, Kenji Sakimura, Takaichi Fukuda, Kohji Fukunaga
T-type voltage-gated Ca(2+) channels (T-VGCCs) function in the pathophysiology of epilepsy, pain and sleep. However, their role in cognitive function remains unclear. We previously reported that the cognitive enhancer ST101, which stimulates T-VGCCs in rat cortical slices, was a potential Alzheimer's disease therapeutic. Here, we introduce a more potent T-VGCC enhancer, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo [1,2-a]pyridin]-2-ene-3-carboxylate), and characterize its pharmacological properties in brain...
January 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28079769/posttraumatic-stress-disorder-relapse-and-clitoral-reconstruction-after-female-genital-mutilation
#8
Jasmine Abdulcadir, Francesco Bianchi Demicheli, Alexia Willame, Nathalie Recordon, Patrick Petignat
BACKGROUND: Evidence on clitoral reconstruction after female genital mutilation is lacking. CASE: A woman with female genital mutilation experiencing clitoral pain during sex consulted to undergo clitoral reconstruction. The surgery was complicated by a wound infection responsible for severe postoperative pain. Such genital pain made our patient recall the traumatic experience of genital mutilation and experience a relapse of posttraumatic stress disorder symptoms...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079443/breastfeeding-in-women-having-experienced-childhood-sexual-abuse
#9
Constanze Elfgen, Niels Hagenbuch, Gisela Görres, Emina Block, Brigitte Leeners
BACKGROUND: Childhood sexual abuse (CSA) can have a serious effect on general and obstetric health. Breastfeeding includes several triggers for memories of abuse experiences, which will likely influence decisions about breastfeeding and its implementation in daily life. This is important since breastfeeding improves maternal well-being and bonding with the child. Research aim: As breastfeeding strongly influences the long-term health of children, we investigated experiences with breastfeeding in women with a history of CSA...
January 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28072803/neural-correlates-of-maladaptive-pain-behavior-in-chronic-neck-pain-a-single-case-control-fmri-study
#10
Konstantin Beinert, Audrey Mouthon, Martin Keller, Michael Mouthon, Jean-Marie Annoni, Wolfgang Taube
Chronic neck pain patients display functional impairments like decreased range of motion, decreased strength, and reduced sensorimotor function. In patients without structural damage, the reason for the persistence of pain is not well understood. Therefore, it is assumed that in chronic pain states, memory processes play an important role. We have now detected and tested a patient that might help us to better understand the neural correlates of maladaptive pain expectation/memory. This patient displays chronic neck pain and restricted unilateral motion of the cervical spine to the left...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28051079/genome-wide-association-scan-of-neuropathic-pain-symptoms-post-total-joint-replacement-highlights-a-variant-in-the-protein-kinase-c-gene
#11
Sophie C Warner, Joyce Bj van Meurs, Dieuwke Schiphof, Sita M Bierma-Zeinstra, Albert Hofman, Andre G Uitterlinden, Helen Richardson, Wendy Jenkins, Michael Doherty, Ana M Valdes
Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a genome-wide association study (GWAS) using NP as defined by the painDETECT questionnaire (score >12 indicating possible NP) in 613 post-TJR participants recruited from Nottinghamshire (UK). The prevalence of possible NP was 17.8%. The top four hits from the GWAS and two other biologically relevant single-nucleotide polymorphisms (SNPs) were replicated in individuals with OA and post TJR from an independent study in the same area (N=908) and in individuals from the Rotterdam Study (N=212)...
January 4, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28043850/allergies-in-orthopaedic-and-trauma-surgery
#12
REVIEW
C H Lohmann, R Hameister, G Singh
Hypersensitivity reactions to implants in orthopaedic and trauma surgery are a rare but devastating complication. They are considered as a delayed-type of hypersensitivity reaction (type IV), characterized by an antigen activation of sensitized T-lymphocytes releasing various cytokines and may result in osteoclast activation and bone resorption. Potential haptens are originated from metal alloys or bone-cement. A meta-analysis has confirmed a higher probability of developing a metal hypersensitivity postoperatively and noted a greater risk of failed replacements compared to stable implants...
December 30, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28043031/liver-5-ht7-receptors-a-novel-regulator-target-of-fibrosis-and-inflammation-induced-chronic-liver-injury-in-vivo-and-in-vitro
#13
Beyzagul Polat, Zekai Halici, Elif Cadirci, Emre Karakus, Yasin Bayir, Abdulmecit Albayrak, Deniz Unal
BACKGROUND AND AIM: Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of the serotonin receptor family and is expressed in both central nerve system and peripheral system and have a lot of functions like learning, memory, smooth muscular relaxation, in the control of circadian rhythms and thermoregulation, pain and migraine, schizophrenia, anxiety, cognitive disturbances, and even inflammation...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28042077/symptom-burden-in-advanced-soft-tissue-sarcoma
#14
Nicholas Gough, Jonathan Koffman, Joy R Ross, Julia Riley, Ian Judson
CONTEXT: There is little information on symptom prevalence and severity in advanced soft tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed and better define optimum timings of palliative and supportive care referrals. OBJECTIVES: To describe symptom prevalence and severity in patients undergoing different treatment options for advanced STS: [i] First-line palliative chemotherapy (FLC) [ii] Active surveillance (AS) pre and post-FLC and [iii] Palliative care (PC) alone...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28042064/homeless-individuals-approaching-the-end-of-life-symptoms-and-attitudes
#15
Matthew Tobey, Julia Manasson, Kristen Decarlo, Katrina Ciraldo-Maryniuk, Jessie M Gaeta, Erica Wilson
CONTEXT: Over a million individuals in the United States experience homelessness annually and homeless individuals die at a higher rate than domiciled peers. Homeless individuals often have unique experiences at the end of life (EOL). OBJECTIVES: This study examined the symptoms experienced by homeless individuals nearing the EOL and explored social background, attitudes and experiences. METHODS: Investigators conducted surveys of homeless individuals approaching the EOL at a medical respite home...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28034975/pain-and-cognitive-functioning-in-adults-with-down-syndrome
#16
Nanda C de Knegt, Frank Lobbezoo, Carlo Schuengel, Heleen M Evenhuis, Erik J A Scherder
OBJECTIVE:  The aim of the present study was to examine whether cognitive functioning (i.e., memory and executive functioning) is related to self-reported presence of pain (i.e., affirmative answer to the question whether the individual feels pain) and experience of pain (i.e., intensity and affect) in adults with Down syndrome (DS). DESIGN, SETTING, AND SUBJECTS:  Cross-sectional study of 224 adults with DS (mean age = 38.1 years, mild-severe intellectual disabilities) in the Netherlands...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28031222/the-chemokine-cxcl12-mediates-the-anti-amyloidogenic-action-of-painless-human-nerve-growth-factor
#17
Simona Capsoni, Francesca Malerba, Nicola Maria Carucci, Caterina Rizzi, Chiara Criscuolo, Nicola Origlia, Mariantonietta Calvello, Alessandro Viegi, Giovanni Meli, Antonino Cattaneo
Nerve growth factor is a therapeutic candidate for Alzheimer's disease. Due to its pain-inducing activity, in current clinical trials nerve growth factor is delivered locally into the brain by neurosurgery, but data on the efficacy of local nerve growth factor delivery in decreasing amyloid-β deposition are not available. To reduce the nerve growth factor pain-inducing side effects, thus avoiding the need for local brain injection, we developed human painless nerve growth factor (hNGFp), inspired by the human genetic disease hereditary sensory and autonomic neuropathy type V...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28031146/visual-perspective-during-remembering-erp-evidence-of-familiarity-based-source-monitoring
#18
P Andrew Leynes, Ben Askin, Joshua D Landau
Autobiographical recollections are accompanied by visual perspectives that can be either a view through the person's own eyes (first-person) or a view that integrates visual characteristics of the rememberer into the reconstructed scene (third-person). Some have argued that a third-person perspective serves as a coping mechanism allowing the person to distance themselves from details of painful memories. The study reported here created first- and third-person memories in a novel experimental paradigm. Later, participants discriminated between these perspectives on a source memory test while event-related potentials (ERPs) were recorded...
December 10, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28030917/application-of-the-bpcq-questionnaire-to-assess-pain-management-in-selected-types-of-cancer
#19
Aleksandra Czerw, Urszula Religioni, Andrzej Deptała, Adam Fronczak
INTRODUCTION: Pain is one of the most prevalent unpleasant sensation in people that may significantly lower the quality of life. More than a half of cancer patients suffer from various forms of pain, which becomes more frequent and intense as disease progresses. OBJECTIVE: The objective of the study was to assess the degree of pain control in patients diagnosed with breast, lung, colorectal and prostate cancer. The analysis also covered the effect of socio-economic factors on pain management in patients with the above types of cancer...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28012859/endogenous-opiates-and-behavior-2015
#20
REVIEW
Richard J Bodnar
This paper is the thirty-eighth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2015 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia, stress and social status, tolerance and dependence, learning and memory, eating and drinking, drug abuse and alcohol, sexual activity and hormones, pregnancy, development and endocrinology, mental illness and mood, seizures and neurologic disorders, electrical-related activity and neurophysiology, general activity and locomotion, gastrointestinal, renal and hepatic functions, cardiovascular responses, respiration and thermoregulation, and immunological responses...
December 22, 2016: Peptides
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