keyword
MENU ▼
Read by QxMD icon Read
search

Painful memory

keyword
https://www.readbyqxmd.com/read/28648984/whole-body-biodistribution-of-the-cannabinoid-type-1-receptor-ligand-18-f-mk-9470-in-the-rat
#1
H G Buchholz, K Uebbing, S Maus, S Pektor, N Afahaene, V Weyer-Elberich, B Lutz, M Schreckenberger, I Miederer
The endocannabinoid system participates in many processes in the body, including memory, reward, pain, motor activity, food intake, energy metabolism, and gastrointestinal functions. [(18)F]MK-9470 is a positron emission tomography (PET) ligand that binds with high affinity and selectivity to the cannabinoid type 1 receptor. In order to fully characterize ligand behavior, tracer uptake measured using in vivo microPET was compared with results from ex vivo tissue dissection. Twelve male Sprague-Dawley rats were divided into three subgroups and scanned over time periods of 10min, 30min and 90min using PET...
June 15, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28626478/comparative-effects-of-chronic-administrations-of-gabapentin-pregabalin-and-baclofen-on-rat-memory-using-object-recognition-test
#2
Asma Salimzade, Ali Hosseini-Sharifabad, Mohammad Rabbani
Memory impairment is one of the greatest concerns when it comes to long-term CNS-affecting drug administration. Drugs like gabapentin, pregabalin and baclofen are administered in a long-term period in conditions such as epilepsy, neuropathic pain, spasticity associated with spinal cord injury or multiple sclerosis. Despite their wide spread use, few data are available on the effects of these drugs on cognitive functions, such as learning memory. In the present study, the effects of long-term administration of gabapentin, pregabalin and baclofen on memory were investigated in a comparative manner...
June 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28606783/methylprednisolone-as-a-memory-enhancer-in-rats-effects-on-aversive-memory-long-term-potentiation-and-calcium-influx
#3
Liane da Silva de Vargas, Rithiele Gonçalves, Marcus Vinícius S Lara, Zaquer S M Costa-Ferro, Simone Denise Salamoni, Michelle Flores Domingues, Angela Regina Piovesan, Dênis Reis de Assis, Lucia Vinade, Alexandre P Corrado, Wilson Alves-Do-Prado, Paulo Correia-de-Sá, Jaderson Costa da Costa, Ivan Izquierdo, Cháriston A Dal Belo, Pâmela B Mello-Carpes
It is well recognized that stress or glucocorticoids hormones treatment can modulate memory performance in both directions, either impairing or enhancing it. Despite the high number of studies aiming at explaining the effects of glucocorticoids on memory, this has not yet been completely elucidated. Here, we demonstrate that a low daily dose of methylprednisolone (MP, 5 mg/kg, i.p.) administered for 10-days favors aversive memory persistence in adult rats, without any effect on the exploring behavior, locomotor activity, anxiety levels and pain perception...
June 9, 2017: Brain Research
https://www.readbyqxmd.com/read/28602549/ovarian-cancer-survivors-acceptance-of-treatment-side-effects-evolves-as-goals-of-care-change-over-the-cancer-continuum
#4
Melissa K Frey, Annie E Ellis, Laura M Koontz, Savannah Shyne, Bernhard Klingenberg, Jessica C Fields, Jing-Yi Chern, Stephanie V Blank
OBJECTIVES: Women with ovarian cancer can have long overall survival and goals of treatment change over time from cure to remission to stable disease. We sought to determine whether survivors' acceptance of treatment side effects also changes over the disease continuum. METHODS: Women with ovarian cancer completed an online survey focusing on survivors' goals and priorities. The survey was distributed through survivor networks and social media. RESULTS: Four hundred and thirty-four women visited the survey website and 328 (76%) completed the survey...
June 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28595276/premorbid-iq-predicts-postconcussive-symptoms-in-oef-oif-ond-veterans-with-mtbi
#5
Jada J Stewart-Willis, Daniel Heyanka, Zoe Proctor-Weber, Heather England, Maya Bruhns
Objective: Extant literature has demonstrated that symptoms of postconcussive syndrome (PCS) persist well beyond the expected 3-month post-injury recovery period in a minority of individuals with mild traumatic brain injury (mTBI). Suboptimal performance on validity measures and pre- and post-injury psychosocial stressors - rather than actual mTBI or current cognitive functioning - have been identified as predictors of chronic PCS. Whether premorbid IQ has any influence on chronic PCS has been understudied, in the context of established psychogenic etiologies...
June 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28589628/chemical-tools-to-modulate-2-ag-biosynthesis
#6
Hui Deng, Mario van der Stelt
2-Arachidonoylglycerol (2-AG) as an important endogenous signaling lipid that activates the cannabinoid receptors (CB1 R and CB2 R), thereby regulating a diverse range of physiological processes including anxiety, appetite, inflammation, memory, pain sensation and nociception. Diacylglycerol lipases (DAGLs) are the principle enzymes responsible for 2-AG biosynthesis. Recently, the (patho)physiological functions of DAGLs have been explored by both genetic methods and chemical tools. This review will focus on the recent efforts to develop highly selective and in vivo active DAGLs inhibitors using activity-based protein profiling...
June 6, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28586818/association-between-persistent-pain-and-memory-decline-and-dementia-in-a-longitudinal-cohort-of-elders
#7
Elizabeth L Whitlock, L Grisell Diaz-Ramirez, M Maria Glymour, W John Boscardin, Kenneth E Covinsky, Alexander K Smith
Importance: Chronic pain is common among the elderly and is associated with cognitive deficits in cross-sectional studies; the population-level association between chronic pain and longitudinal cognition is unknown. Objective: To determine the population-level association between persistent pain, which may reflect chronic pain, and subsequent cognitive decline. Design, Setting, and Participants: Cohort study with biennial interviews of 10 065 community-dwelling older adults in the nationally representative Health and Retirement Study who were 62 years or older in 2000 and answered pain and cognition questions in both 1998 and 2000...
June 5, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28579842/short-and-long-term-health-consequences-of-sleep-disruption
#8
REVIEW
Goran Medic, Micheline Wille, Michiel Eh Hemels
Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28571775/critical-role-of-ca1-muscarinic-receptors-on-memory-acquisition-deficit-induced-by-total-tsd-and-rem-sleep-deprivation-rsd
#9
Bibi-Zahra Javad-Moosavi, Gholamhassan Vaezi, Mohammad Nasehi, Seyed-Ali Haeri-Rouhani, Mohammad-Reza Zarrindast
AIM: Despite different theories regarding sleep physiological function, an overall census indicates that sleep is useful for neural plasticity which eventually strengthens cognition and brain performance. Different studies show that sleep deprivation (SD) leads to impaired learning and hippocampus dependent memory. According to some studies, cholinergic system plays an important role in sleep (particularly REM sleep), learning, memory, and its retrieval. So this study has been designed to investigate the effect of CA1 Cholinergic Muscarinic Receptors on memory acquisition deficit induced by total sleep deprivation (TSD) and REM sleep deprivation (RSD)...
May 30, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28554357/accuracy-of-children-s-perioperative-memories
#10
Thomas Hackmann, Rebecca A Haworth, Paul Hong, Joanne Gillespie, Jill Chorney
Children's declarative memories of medical procedures can influence their responses to subsequent events. No previous study has examined the accuracy of children's declarative memories after surgery. We tested the memory of 34 anesthesia-naïve five- to nine-year-old children undergoing ambulatory surgery for accuracy of contextual details, pain, and fear two weeks postoperatively. Parents were not present during induction, and we did not use sedative premedication. Children had a mean contextual recall accuracy of 64...
June 2017: AORN Journal
https://www.readbyqxmd.com/read/28553223/chronic-monoarthritis-pain-accelerates-the-processes-of-cognitive-impairment-and-increases-the-nmdar-subunits-nr2b-in-ca3-of-hippocampus-from-5-month-old-transgenic-app-ps1-mice
#11
Wei-Yi Gong, Rong Wang, Yuan Liu, He Jin, Zhi-Wei Zhao, Yu-Lan Wang, Hong-Yan Li, Xu Zhang, Jia-Xiang Ni
Many factors impact cognitive impairment; however, the effects of chronic pain and the mechanisms underlying these effects on cognitive impairment are currently unknown. Here we tested the hypothesis that chronic pain accelerates the transition from normal cognition to mild cognitive impairment (MCI) in 5-month-old transgenic APP/PS1 mice, an animal model of Alzheimer's disease (AD), and that neurotoxicity induced by N-methyl-D-aspartic acid receptor (NMDAR) subunits may be involved in this process. Chronic monoarthritis pain was induced in transgenic APP/PS1 mice and 5-month-old wild-type (WT) mice by intra- and pre-articular injections of Freund's complete adjuvant (FCA) into one knee joint...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28549613/symptom-experience-in-late-pregnancy
#12
Kathleen R Beebe, Caryl L Gay, Sarah E Richoux, Kathryn A Lee
OBJECTIVE: To evaluate the frequency, severity, distress, and correlates of common and rare symptoms reported by nulliparous women during the last month of pregnancy. DESIGN: Secondary cross-sectional analysis of data obtained in a larger randomized clinical trial. SETTING: San Francisco Bay area. PARTICIPANTS: Nulliparous, ethnically diverse, predominantly low-income pregnant women 18 to 47 years of age (N = 151). METHODS: Participants at or beyond 36 weeks gestation used the Memorial Symptom Assessment Scale (MSAS) to provide self-reports of general symptom experience ...
May 23, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28542002/assessment-of-behavioral-disruption-in-rats-with-abdominal-inflammation-using-visual-cue-titration-and-the-five-choice-serial-reaction-time-task
#13
Thomas J Martin, Tracy J Strassburg, Amanda L Grigg, Susy A Kim, Douglas G Ririe, James C Eisenach
BACKGROUND: Both acute and chronic pain result in a number of behavioral symptoms in patients, including cognitive effects such as decreased attention and working memory. Intraperitoneal administration of dilute lactic acid in rodents has been used to induce abdominal inflammation and produce effects in behavioral assays of both sensory-discriminative and affective pain modalities. METHODS: Intraperitoneal injection of dilute lactic acid was used to study the impact of abdominal inflammation on an operant task requiring sustained visual attention in rats (N = 7 to 15/group) that adapts dynamically to performance ability...
May 25, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28540352/dataset-on-galanin-receptor-3-mutants-that-improve-recombinant-receptor-expression-and-stability-in-an-agonist-and-antagonist-bound-form
#14
Thao T Ho, Jasmine T Nguyen, Juping Liu, Pawel Stanczak, Aaron A Thompson, Yingzhuo G Yan, Jasmine Chen, Charles K Allerston, Charles L Dillard, Hao Xu, Nicholas J Shoger, Jill S Cameron, Mark E Massari, Kathleen Aertgeerts
Galanin Receptor 3 (GALR3) is a G-protein-coupled receptor with a widespread distribution in the brain and plays a role in a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. Therefore, GALR3 is considered an attractive CNS drug target (Freimann et al., 2015) [1]. This dataset contains GALR3 point mutants that improve recombinant protein expression and thermal stability of the receptor contained in virus-like particles (VLPs) or obtained by detergent-purification of baculovirus-infected insect cells...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28533953/interplay-among-pain-intensity-sleep-disturbance-and-emotion-in-patients-with-non-specific-low-back-pain
#15
Shilabant Sen Sribastav, He Peiheng, Long Jun, Li Zemin, Wei Fuxin, Wang Jianru, Liu Hui, Wang Hua, Zheng Zhaomin
BACKGROUND: Low back pain (LBP) is the most common problem worldwide. There are several negative consequences of LBP, such as sleep disorders, work leave, disability, depression, anxiety, and poor quality of life. In this study, we designed to evaluate the prevalence of sleep disturbance in patients with non-specific LBP(NSLBP), and cross-correlation among sleep disorder, anxiety, depression and pain intensity in patients with NSLBP. AIM: In this study, we designed to evaluate the prevalence of sleep disturbance in patients with NSLBP, and cross-correlation among sleep disorder, anxiety, depression and pain intensity in patients with NSLBP...
2017: PeerJ
https://www.readbyqxmd.com/read/28525629/the-association-of-perceived-memory-loss-with-osteoarthritis-and-related-joint-pain-in-a-large-appalachian-population
#16
Kim E Innes, Usha Sambamoorthi
Objective. : Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the second most common cause of chronic pain, remains little explored. In this cross-sectional study, we examine the association of perceived memory loss to OA and assess the potential mediating influence of sleep and mood disturbance in a large Appalachian population. Design.:  Cross-sectional...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28521778/cortical-kainate-receptors-and-behavioral-anxiety
#17
REVIEW
Min Zhuo
The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP...
May 18, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28520755/neuropsychological-characteristics-of-gulf-war-illness-a-meta-analysis
#18
Patricia A Janulewicz, Maxine H Krengel, Alexis Maule, Roberta F White, Joanna Cirillo, Emily Sisson, Timothy Heeren, Kimberly Sullivan
OBJECTIVE: Gulf War illness (GWI) is a disorder related to military service in the 1991 GW. Prominent symptoms include fatigue, pain and cognitive problems. These symptoms were reported by GW Veterans (GWV) immediately after the war and were eventually incorporated into case definitions of GWI. Neuropsychological function in GW veterans has been studied both among deployed GWV and in GWV diagnosed with GWI. Results have been inconsistent between and across GW populations. The purpose of the present investigation was to better characterize neuropsychological function in this veteran population...
2017: PloS One
https://www.readbyqxmd.com/read/28515230/crosstalk-from-camp-to-erk1-2-emerges-during-postnatal-maturation-of-nociceptive-neurons-and-is-maintained-during-aging
#19
Joerg Isensee, Cosimo Schild, Frank Schwede, Tim Hucho
Maturation of nociceptive neurons depends on changes of transcription factors, ion channels, and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. If sensitization signaling also changes during development and aging remains so far unknown.Using a novel automated microscopy approach, we quantified changes of intracellular signaling protein expression, of their signaling dynamics, as well as of intracellular signaling cascade wiring in sensory neurons from newborn to senescent rats...
May 17, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28511826/use-of-hypnosis-meditation-and-biofeedback-in-dermatology
#20
Philip D Shenefelt
Hypnosis utilizes trance to access otherwise inaccessible repressed or unconscious memories and features of the psyche and control of physiology not attainable in the ordinary conscious waking state. Medical uses of hypnosis in dermatology include reducing discomfort from itching or skin pain, altering ingrained dysfunctional habits such as scratching, promoting healing of skin disorders, searching for psychosomatic aspects of skin disorders and alleviating them, and reframing cognitive and emotional dysfunctional patterns related to skin disorders...
May 2017: Clinics in Dermatology
keyword
keyword
85909
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"