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https://www.readbyqxmd.com/read/27453669/giant-cystic-pheochromocytoma-a-silent-entity
#1
Amit Gupta, Lovenish Bains, Manish Kumar Agarwal, Renu Gupta
Pheochromocytoma is a catecholamine secreting tumor that originate from chromaffin cells. Usually, it is solid neoplasm of the adrenal medulla, however cystic pheochromocytoma is a rare neuro-endocrine tumour that is frequently asymptomatic and often diagnosed incidentally on imaging or intra-operatively. Only a few cases of cystic pheochromocytomas have been reported in the world literature. We present a case of giant cystic pheochromocytoma in a 65 years old lady who presented with a large retroperitoneal lump, which is probably the world's third largest pheochromocytoma as per the available indexed literature...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27449685/secreting-follicle-stimulating-hormone-pituitary-carcinoma-with-cervical-metastasis
#2
Carly Grandidge, Andy Hall, Neil Kitchen
BACKGROUND: Pituitary carcinoma is defined by either metastases outside the central nervous system or noncontiguous foci within the central nervous system. This case report details the first documented case of a pathologically isolated follicle-stimulating hormone-secreting pituitary carcinoma and its presentation of metastasis. CASE DESCRIPTION: A 63-year-old man developed intrascapular pain radiating up his neck to his occiput. He had undergone a transsphenoidal hypophysectomy 2 years previously for an atypical pituitary macroadenoma...
September 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26693194/neuro-ophthalmic-and-clinical-characteristics-of-brain-tumours-in-a-tertiary-hospital-in-ghana
#3
N N Tagoe, V A Essuman, G Fordjuor, J Akpalu, P Bankah, T Ndanu
BACKGROUND: Anecdotally, increasing number of patients are seen at Korle Bu Teaching Hospital (KBTH) with brain tumour. Neuro-ophthalmic symptoms and signs may help in timely diagnosis and intervention. OBJECTIVE: To evaluate the neuro-ophthalmic and clinical characteristics of brain tumour in patients presenting at a tertiary hospital in Ghana. STUDY DESIGN: A prospective case series involving 36 consecutive patients newly diagnosed with brain tumour from November 2010 to October 2011, at the Ophthalmology, Neurosurgery and Endocrine units of KBTH, Ghana...
September 2015: Ghana Medical Journal
https://www.readbyqxmd.com/read/26678526/pancreatic-enucleation-using-the-da-vinci-robotic-surgical-system-a-report-of-26-cases
#4
Yusheng Shi, Chenghong Peng, Baiyong Shen, Xiaxing Deng, Jiabin Jin, Zhichong Wu, Qian Zhan, Hongwei Li
BACKGROUND: As a tissue-sparing procedure, pancreatic enucleation has become an alternative for benign or borderline pancreatic tumours; it has been proved to be safe and feasible. To date, a large sample size of robotic pancreatic enucleation has not been reported. This study aimed to discuss the clinical evaluation and postoperative complications after robotic pancreatic enucleation and compare it with open surgery. METHODS: Patients who underwent robotic or open pancreatic enucleation during December 2010-December 2014 at Shanghai Ruijin Hospital, affiliated with the Shanghai Jiaotong University School of Medicine in China, were included...
December 18, 2015: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/26377169/defining-the-role-of-proton-therapy-in-the-optimal-management-of-paediatric-patients-in-australia-and-new-zealand
#5
Mary Dwyer
INTRODUCTION: Optimal management of paediatric patients with tumours may include radiation therapy. Proton therapy, in theory, should achieve superior outcomes. For children referred overseas, multiple factors are taken into consideration. AIM AND METHODS: The purpose of this article is to provide context to current decision making. The MEDLINE, EMBASE and PubMed databases were searched for relevant literature. RESULTS AND DISCUSSION: The delivery of proton therapy is in evolution...
February 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/26257075/diagnosis-and-treatment-of-merkel-cell-carcinoma-european-consensus-based-interdisciplinary-guideline
#6
REVIEW
Celeste Lebbe, Jürgen C Becker, Jean-Jacques Grob, Josep Malvehy, Veronique Del Marmol, Hubert Pehamberger, Ketty Peris, Philippe Saiag, Mark R Middleton, Lars Bastholt, Alessandro Testori, Alexander Stratigos, Claus Garbe
Merkel cell carcinoma (MCC) is a rare tumour of the skin of neuro-endocrine origin probably developing from neuronal mechanoreceptors. A collaborative group of multidisciplinary experts form the European Dermatology Forum (EDF), The European Association of Dermato-Oncology (EADO) and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on MCC diagnosis and management, based on a critical review of the literature, existing guidelines and expert's experience...
November 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/25822436/diagnostic-performance-of-endoscopic-ultrasound-eus-endoscopic-ultrasound-fine-needle-aspiration-eus-fna-cytology-in-solid-and-cystic-pancreatic-neuroendocrine-tumours
#7
COMPARATIVE STUDY
Vikramjit Mitra, Manu K Nayar, John S Leeds, Viney Wadehra, Beate Haugk, John Scott, Richard M Charnley, Kofi W Oppong
BACKGROUND AND AIMS: Our study aimed to assess the sensitivity of EUS and EUS-FNA for pancreatic neuro-endocrine tumors (pNETs) and compare performance over two consecutive 4 year 2 month periods, to investigate the comparative performance between solid and cystic pNETs and determine the incremental yield of EUS +/- FNA in individuals with a mass not diagnosed as a pNET after cross-sectional imaging. METHODS: A retrospective review of a prospectively maintained database was carried out to identify all pNET patients who underwent EUS-FNA between April 2003 and September 2011...
March 2015: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/25691214/limited-surgery-for-benign-tumours-of-the-pancreas-a-systematic-review
#8
REVIEW
H G Beger, M Siech, B Poch, B Mayer, M H Schoenberg
BACKGROUND: Limited surgical procedures for benign cystic neoplasms and endocrine tumours of the pancreas have the potential advantage of pancreatic tissue sparing compared to standard oncological resections. METHODS: Searching PubMed/MedLine, Embase and Cochrane Library identified 86 full papers: 25 reporting on enucleation (EN), 38 on central pancreatectomy (CP) and 23 on duodenum-preserving total/partial pancreatic head resection (DPPHRt/p). The results are based on analysis of data of 838, 912 and 431 patients for EN, CP and DPPHRt/s, respectively...
June 2015: World Journal of Surgery
https://www.readbyqxmd.com/read/25386444/insulinoma-a-comprehensive-summary-of-two-cases
#9
Pankaj Sharma, Sonia Sharma, Shivani Kalhan, Bhanu Pratap Singh, Sonam Sharma
Pancreatic endocrine tumours are rare in occurrence. They may present with a baffling range of symptoms which pose a diagnostic dilemma. Two cases of pancreatic insulinoma are presented herewith. Both presented with neuro-psychiatric complaints and were treated symptomatically for depression, anxiety, seizures etc. The diagnosis in these patients was missed for years. Insulinoma being a great diagnostic challenge, requires reasonably high clinical suspicion, accurate biochemical diagnosis and radiological localization to avoid extensive surgery...
September 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24999576/primitive-eyelid-merkel-carcinoma
#10
A Laborante, C Longo
Primitive Merkel Cell Carcinoma (MCC) of the eyelid is a malign cutaneous neuro-endocrine tumour that originates in Merkel cells; which are situated along the border of the eyelid between the eyelashes. It is a rare, very aggressive and metastasising tumour. The histo-pathological diagnosis may require an immuno-histochemical and ultrastructural analysis. The authors describe the clinical case of a 65-year-old woman with palpebral MCC that appeared suddenly over a period of three months. The correct therapeutic strategy for Merkel cell cancer is a radical, aggressive and early removal of the tumour at its initial stage, in order to reduce the risk of a distant recurrence and to improve the survival rate...
2014: La Clinica Terapeutica
https://www.readbyqxmd.com/read/24807212/liver-transplantation-for-metastatic-liver-malignancies
#11
REVIEW
Aksel Foss, Jan P Lerut
PURPOSE OF REVIEW: Liver transplantation is a validated treatment of primary hepatobiliary tumours. Over the last decade, a renewed interest for liver transplantation as a curative treatment of colorectal liver metastasis (CR-LM) and neuro-endocrine metastasis (NET-LM) has developed. RECENT FINDINGS: The ELTR and UNOS analyses showed that liver transplantation may offer excellent disease-free survival (ranging from 30 to 77%) in case of NET-LM, on the condition that stringent selection criteria are implemented...
June 2014: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/24742543/benign-cystic-neoplasm-and-endocrine-tumours-of-the-pancreas-when-and-how-to-operate-an-overview
#12
REVIEW
H G Beger, B Poch, C Vasilescu
BACKGROUND: The recent evolution of limited local operative procedures for benign pancreatic lesions shifted surgical treatment options to the application of local techniques, although major resections of pancreatic head and left resection are still the standard. OBJECTIVES: To evaluate the level of evidence of tumour enucleation (EN), pancreatic middle segment resection (PMSR) and duodenum preserving total/subtotal pancreatic head resection (DPPHRt/s), we focus based on present knowledge on indication to surgical treatment evaluating the questions, when and how to operate...
2014: International Journal of Surgery
https://www.readbyqxmd.com/read/24440311/enteroscopy-for-the-early-detection-of-small-bowel-tumours-in-at-risk-celiac-patients
#13
Carolina Tomba, Luca Elli, Maria Teresa Bardella, Marco Soncini, Paolo Contiero, Leda Roncoroni, Martina Locatelli, Dario Conte
BACKGROUND: A subset of celiac patients shows a high risk for small bowel malignancies. AIMS: To select celiac patients considered at risk and evaluate the diagnostic yield of enteroscopy in this context. METHODS: Celiac patients were enrolled from a tertiary referral centre during the period June 2011-June 2013, based on the following criteria: (i) patients diagnosed when aged 50+ and with poor response to gluten-free dieting; (ii) low dietary compliance; (iii) alarm symptoms...
May 2014: Digestive and Liver Disease
https://www.readbyqxmd.com/read/24277232/search-for-neuro-endocrine-markers-chromogranin-a-synaptophysin-and-vgf-in-breast-cancers-an-integrated-approach-using-immunohistochemistry-and-gene-expression-profiling
#14
Laura Annaratone, Enzo Medico, Nelson Rangel, Isabella Castellano, Caterina Marchiò, Anna Sapino, Gianni Bussolati
Discordant data are reported in the literature on the definition, incidence and clinical features of neuroendocrine (NE) carcinomas of the breast. This tumour entity is currently assessed by immunohistochemistry (IHC) detecting "general" NE markers such as chromogranin A (CHGA) and synaptophysin (SYP), but other markers have been considered as well. In the present study, in addition to CHGA and SYP, we investigated the expression of VGF, a neurotrophin-inducible gene, which is emerging as a new specific NE marker...
September 2014: Endocrine Pathology
https://www.readbyqxmd.com/read/24133392/early-outcome-in-endoscopic-extended-endonasal-approach-for-removal-of-supradiaphragmatic-craniopharyngiomas-a-case-series-and-a-comprehensive-review
#15
Roman Bosnjak, Mitja Benedicic, Alenka Vittori
BACKGROUND: The choice of endoscopic expanded endonasal approach introduces the possibility of improved gross total resection of craniopharyngioma while minimizing surgical morbidity in a significant subset of patients. METHODS: From our trans-sphenoidal surgical series of 331 cases, we retrospectively reviewed visual, endocrine and neuro-cognitive outcomes in the first consecutive eight patients (median age 63 years; range 47-73 years) with newly diagnosed supradiaphragmatic craniopharyngioma (median tumour height 23 mm; range 15-34 mm), removed by expanded endonasal approach (median follow-up 27 months; range 10-69 months)...
2013: Radiology and Oncology
https://www.readbyqxmd.com/read/23807607/radiation-induced-hypopituitarism
#16
REVIEW
Ken H Darzy
PURPOSE OF REVIEW: Progressive and irreversible neuro-endocrine dysfunction following radiation-induced damage to the hypothalamic-pituitary (h-p) axis is the most common complication in cancer survivors with a history of cranial radiotherapy involving the h-p axis and in patients with a history of conventional or stereotactic pituitary radiotherapy for pituitary tumours. This review examines the controversy about the site and pathophysiology of radiation damage while providing an epidemiological perspective on the frequency and pattern of radiation-induced hypopituitarism...
August 2013: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/23548969/relevance-of-incidental-colorectal-fdg-pet-ct-enhanced-lesions
#17
Paul M Putora, Joachim Müller, Jan Borovicka, Ludwig Plasswilm, Felix Schmidt
INTRODUCTION: Positron emission tomography/computed tomographies (PET/CTs) may result in incidental findings of fluorodeoxyglucose (FDG)-avid lesions in the colon. The aim of this study was to assess the relevance of a colonoscopic workup of such lesions. PATIENTS AND METHODS: We retrospectively analysed all PET/CT reports (n = 4,973) generated in our nuclear medicine department between May 2006 and May 2011; in 69 cases a colonoscopic evaluation was recommended for incidental FDG-avid lesions...
2013: Onkologie
https://www.readbyqxmd.com/read/22856448/unexpected-intra-operative-diagnosis-of-a-large-cystic-phaeochromocytoma-and-secondary-nifedipine-pharmacobezoar
#18
D N Ginther, S Kriegler, R Kanthan, J M Shaw
Cystic phaeochromocytoma is a rare neuro-endocrine tumour that is frequently asymptomatic and often diagnosed incidentally on imaging or intra-operatively. A pharmacobezoar is a rare complication of extended-release drug delivery systems. We present a case of a 70-year-old woman diagnosed intra-operatively with cystic phaeochromocytoma and antihypertensive pharmacobezoar.
August 2012: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/22853763/-giant-haemangioma-of-the-liver-diagnosis-and-treatment
#19
L T Hoekstra, M Bieze, D Erdogan, J J T H Roelofs, U H W Beuers, T M van Gulik
- A liver haemangioma is a benign, usually small tumour comprised of blood vessels, which is often discovered coincidentally; giant haemangiomas are defined as haemangiomas larger than 5 cm.- The differential diagnosis includes other hypervascular tumours, such as hepatocellular adenoma, hepatocellular carcinoma, metastasis of a neuro-endocrine tumour or renal cell carcinoma.- The diagnosis is based on abdominal ultrasonography and can be confirmed by a CT or MR scan.- A wait-and-see approach is justified in patients without symptoms or with minimal symptoms, even in the presence of a giant haemangioma...
2012: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/22851846/recurrent-peptic-ulcer-due-to-carcinoid-tumour-of-jejunum
#20
Parimal Bhattacharyya
Carcinoid Tumours are classified as Neuro-endocrine tumours. Commonly known ulcerogenic neuro-endocrine tumour is Gastrinoma of the Pancreas and Duodenum.It secretes hormone Gastrin which causes hyperplasia of the gastric parietal cells with excessive secretion of hydrochloric acid resulting in multiple ulcerations in the stomach, duodenum and upper jejunum. Carcinoid tumours is not known to cause peptic ulceration.
August 2011: Indian Journal of Surgery
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