keyword
https://read.qxmd.com/read/38489977/generation-of-a-human-induced-pluripotent-stem-cell-line-harboring-heteroplasmic-m-3243a%C3%A2-%C3%A2-g-mutation-in-mt-tl1-gene
#21
JOURNAL ARTICLE
Min Song, Shuangshuang Chen, Manna Zhang, Shijun Hu, Wei Lei, Miao Yu
Mitochondrial diseases are disorders caused primarily by mutations in mitochondrial DNA, with the mitochondrial 3243A > G (m.3243A > G) mutation being one of the most common pathogenic mutations. Here, a pluripotent stem cell line with high m.3243A > G mutation load was generated by reprogramming the skin fibroblasts from a patient with mitochondrial disease. This cell line exhibited pluripotency, multilineage differentiation potential and normal karyotype, representing a valuable cell resource for studying the pathogenesis of mitochondrial diseases and screening drugs...
March 12, 2024: Stem Cell Research
https://read.qxmd.com/read/38487264/translational-frontiers-insight-from-lymphatics-in-skin-regeneration
#22
REVIEW
Yujia Jiang, Mirna Perez-Moreno
The remarkable regenerative ability of the skin, governed by complex molecular mechanisms, offers profound insights into the skin repair processes and the pathogenesis of various dermatological conditions. This understanding, derived from studies in human skin and various model systems, has not only deepened our knowledge of skin regeneration but also facilitated the development of skin substitutes in clinical practice. Recent research highlights the crucial role of lymphatic vessels in skin regeneration. Traditionally associated with fluid dynamics and immune modulation, these vessels are now recognized for interacting with skin stem cells and coordinating regeneration...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38484819/recombinant-human-collagen-i-carboxymethyl-chitosan-hydrogel-loaded-with-long-term-released-hucmscs-derived-exosomes-promotes-skin-wound-repair
#23
JOURNAL ARTICLE
Qiong Wu, Yayuan Guo, Hongwei Li, Dan Zhang, Shixu Wang, Jianing Hou, Nanqiong Cheng, Mengfei Huang, Linna Luo, Yuan Li, Yurong Zhao, Hong Tan, Changxin Jin
BACKGROUND: Stem cell exosomes are beneficial in accelerating wound repair. However, the therapeutic function is limited due to its rapid clearance in vivo. To improve the functionality of exosomes in cutaneous wound healing, a novel hydrogel was designed and fabricated by recombinant human collagen I and carboxymethyl chitosan loaded with exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs), named as the rhCol I/CMC-Exos hydrogel. METHODS: Exosomes were extracted from hUCMSCs and were characterizated by TEM (Transmission Electron Microscopy), and biomarker detection...
March 12, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38484449/establishment-of-an-induced-pluripotent-stem-cell-ipsc-line-inndsui005-a-from-a-healthy-female-chinese-han
#24
JOURNAL ARTICLE
Wenzhu Liu, Yingxin Wang, Yitong Yang, Yu Wang, Yao Tang, Yichang Jiao, Didi Shan, Zexin Zhan, Rui Zhang, Dongdong Wang, Xiaohan Sun, Ping Sun, Xiulian Sun, Chuanzhu Yan, Fuchen Liu
We obtained skin fibroblasts from a 34-year-old healthy woman and established a human induced pluripotent stem cell (hiPSC) line (INDSUi005-A) using a non-integrated reprogramming approach. The obtained cells have typical characteristics of embryonic stem cells, can express specific pluripotency markers and have the ability to differentiate into three germ layers in vitro. This iPSC cell line can be used as an in vitro model for studying disease mechanisms and developing novel therapies.
March 12, 2024: Stem Cell Research
https://read.qxmd.com/read/38481799/exosomes-the-emerging-mechanisms-and-potential-clinical-applications-in-dermatology
#25
REVIEW
Honghao Yu, Heting Feng, Hong Zeng, Yiping Wu, Qi Zhang, Jing Yu, Kai Hou, Min Wu
Skin tissue, composed of epidermis, dermis, and subcutaneous tissue, is the largest organ of the human body. It serves as a protective barrier against pathogens and physical trauma and plays a crucial role in maintaining homeostasis. Skin diseases, such as psoriasis, dermatitis, and vitiligo, are prevalent and can seriously impact the quality of patient life. Exosomes are lipid bilayer vesicles derived from multiple cells with conserved biomarkers and are important mediators of intercellular communication. Exosomes from skin cells, blood, and stem cells, are the main types of exosomes that are involved in modulating the skin microenvironment...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38481114/the-combination-of-bioactive-herbal-compounds-with-biomaterials-for-regenerative-medicine
#26
JOURNAL ARTICLE
Guoying Zhou, Ruojiao Xu, Thomas Groth, Yanying Wang, Xingyu Yuan, Hua Ye, Xiaobing Dou
Regenerative medicine aims to restore the function of diseased or damaged tissues and organs by cell therapy, gene therapy, and tissue engineering, along with the adjunctive application of bioactive molecules. Traditional bioactive molecules such as growth factors and cytokines have shown great potential in regulation of cellular and tissue behavior, but have the disadvantages of limited source, high cost, short half-life, and side effects. In recent years, herbal compounds extracted from natural plants/herbs have gained increasing attention...
March 13, 2024: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/38478637/anti-laminin-332-antibodies-in-graft-versus-host-disease-associated-bullous-pemphigoid-after-allogeneic-peripheral-blood-stem-cell-transplantation
#27
JOURNAL ARTICLE
Yasutoshi Hida, Riho Kageji, Hirofumi Bekku, Norito Ishii
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses...
October 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38475908/dermal-stiffness-governs-the-topography-of-the-epidermis-and-the-underlying-basement-membrane-in-young-and-old-human-skin
#28
JOURNAL ARTICLE
Eva Roig-Rosello, Guila Dayan, Simone Bovio, Patricia Manissier, Elisabeth Errazuriz, Patricia Rousselle
The epidermis is a stratified epithelium that forms the outer layer of the skin. It is composed primarily of keratinocytes and is constantly renewed by the proliferation of stem cells and their progeny that undergo terminal differentiation as they leave the basal layer and migrate to the skin surface. Basal keratinocytes rest on a basement membrane composed of an extracellular matrix that controls their fate via integrin-mediated focal adhesions and hemidesmosomes which are critical elements of the epidermal barrier and promote its regenerative capabilities...
March 12, 2024: Aging Cell
https://read.qxmd.com/read/38474408/scarring-and-skin-fibrosis-reversal-with-regenerative-surgery-and-stem-cell-therapy
#29
REVIEW
Aurora Almadori, Peter Em Butler
Skin scarring and fibrosis affect millions of people worldwide, representing a serious clinical problem causing physical and psychological challenges for patients. Stem cell therapy and regenerative surgery represent a new area of treatment focused on promoting the body's natural ability to repair damaged tissue. Adipose-derived stem cells (ASCs) represent an optimal choice for practical regenerative medicine due to their abundance, autologous tissue origin, non-immunogenicity, and ease of access with minimal morbidity for patients...
March 3, 2024: Cells
https://read.qxmd.com/read/38474251/the-efficacy-of-stem-cells-in-wound-healing-a-systematic-review
#30
REVIEW
Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472408/long-term-outcomes-of-nonmyeloablative-allogeneic-stem-cell-transplantation-with-tseb-tli-and-atg-for-mycosis-fungoides-and-sezary-syndrome
#31
JOURNAL ARTICLE
S L Morris, B R Thomas, R Palanicawandar, S Whittaker, F Child, M Wain, V Sim, R Szydlo, S Mangar, E Olavarria, S Lozano Cerrada, A Muzamil, E Kanfer
Advanced stage (IIB-IVB) Mycosis Fungoides (MF) and Sezary Syndrome (SS) have a poor prognosis with median survival <5 years. We report long-term outcomes of a non-myeloablative allogeneic stem cell transplantation regimen consisting of total skin electron beam therapy, total lymphoid irradiation and antithymocyte globulin. Our prospective cohort consisted of 41 patients with a higher proportion of MF (34MF, 7SS). Acute GVHD Grade 2 to 4 was seen in 31.7% and chronic GVHD Grade 2 to 4 in 24%. The cumulative incidence of non-relapse mortality was 9...
March 12, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38471219/surgical-release-of-the-chest-wall-skin-and-fascia-for-sclerodermatous-graft-versus-host-disease-causing-restrictive-lung-disease-a-case-report
#32
Mitchell Nash, Kim Cartwright, Rebecca Nguyen, Peter Middleton, Peter Maitz
INTRODUCTION: Graft versus host disease (GVHD) remains a significant source of morbidity and mortality in the setting of allogeneic stem cell transplantation. Skin involvement is reported to be as high as 70-95 % in this group with GVHD and the severity of the involvement varies widely. Surgical management of complications of severe cutaneous GVHD is uncommon and is rarely mentioned as a treatment option. CASE PRESENTATION: We present a case of severe sclerodermatous skin changes restricting chest expansion and exercise tolerance to the point of limiting basic activities of daily life...
March 7, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38470456/decellularized-placental-sponge-seeded-with-human-mesenchymal-stem-cells-improves-deep-skin-wound-healing-in-the-animal-model
#33
JOURNAL ARTICLE
Sanaz Alizadeh, Leila Mahboobi, Modara Nasiri, Zahra Khosrowpour, Sadjad Khosravimelal, Fatemeh Asgari, Mahdieh Gholipour-Malekabadi, Seyyed Mohammad Taghi Razavi-Toosi, Narendra Pal Singh Chauhan, Faezeh Ghobadi, Hajar Nasiri, Mazaher Gholipourmalekabadi
Skin injuries lead to a large burden of morbidity. Although numerous clinical and scientific strategies have been investigated to repair injured skin, optimal regeneration therapy still poses a considerable obstacle. To address this challenge, decellularized extracellular matrix-based scaffolds recellularized with stem cells offer significant advancements in skin regeneration and wound healing. Herein, a decellularized human placental sponge (DPS) was fabricated using the decellularization and freeze-drying technique and then recellularized with human adipose-derived mesenchymal cells (MSCs)...
March 12, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38469097/-in-vitro-characterization-of-cells-derived-from-a-patient-with-the-gla-variant-c-376a-g-p-s126g-highlights-a-non-pathogenic-role-in-fabry-disease
#34
JOURNAL ARTICLE
Maximilian Breyer, Julia Grüner, Alexandra Klein, Laura Finke, Katharina Klug, Markus Sauer, Nurcan Üçeyler
Fabry disease (FD) is a life-limiting disorder characterized by intracellular globotriaosylceramide (Gb3) accumulations. The underlying α-galactosidase A (α-GAL A) deficiency is caused by variants in the gene GLA . Variants of unknown significance (VUS) are frequently found in GLA and challenge clinical management. Here, we investigated a 49-year old man with cryptogenic lacunar cerebral stroke and the chance finding of the VUS S126G, who was sent to our center for diagnosis and initiation of a costly and life-long FD-specific treatment...
March 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38467081/survey-of-european-blood-and-marrow-transplant-ebmt-nurses-to-explore-the-current-topical-skin-management-of-chronic-cutaneous-graft-versus-host-disease-in-the-real-world-clinical-environment
#35
JOURNAL ARTICLE
John Murray, Sarah Liptrott, Marta Canesi, Jarl Mooyaart, Annika Kisch, Brian Piepenbroek, Jacqui Stringer
PURPOSE: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. METHOD: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centres. Eligibility required more than 30% of treated patients having allogeneic haematopoietic cell transplant...
March 5, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38465565/%C3%AE-catenin-activation-in-gli-1-stem-cells-leads-to-reprograming-of-the-hair-follicle
#36
JOURNAL ARTICLE
Jimin Han, Weiwei Chu, Kaijun Lin, Xusheng Wang, Ying Gao
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38463491/therapeutic-potential-of-adipose-derived-stromal-cells-for-major-skin-inflammatory-diseases
#37
REVIEW
Marina Ramírez Galera, Jesper Svalgaard, Anders Woetmann
Inflammatory skin diseases like psoriasis and atopic dermatitis are chronic inflammatory skin conditions continuously under investigation due to increased prevalence and lack of cure. Moreover, long-term treatments available are often associated with adverse effects and drug resistance. Consequently, there is a clear unmet need for new therapeutic approaches. One promising and cutting-edge treatment option is the use of adipose-derived mesenchymal stromal cells (AD-MSCs) due to its immunomodulatory and anti-inflammatory properties...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38462125/spry1-deficiency-in-keratinocytes-induces-follicular-melanocyte-stem-cells-migration-to-epidermis-through-p53-scf-c-kit-signaling
#38
JOURNAL ARTICLE
Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhao-Yuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi-Bei Chen, Yu-Xin Zheng, Xue-Yan Chen, Li-Ran Ye, Ying-Ying Li, Xiao-Yong Man
The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response. However, how keratinocytes and melanocytes interact in the absence of UV exposure is unknown. Here, we demonstrate that after SPRY1 knockout in epidermal keratinocytes, melanocyte stem cells (McSCs) in the hair follicle exit the niche without depleting the pool of these cells. We also found that McSCs migrate to the epidermis in a p53/SCF/C-KIT-dependent manner induced by a tanning-like response resulting from SPRY1 loss in epidermal keratinocytes...
March 8, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38460235/generation-of-an-induced-pluripotent-stem-cell-ipsc-line-from-a-parkinson-s-disease-patient-with-a-pathogenic-lrp10-c-688c%C3%A2-%C3%A2-t-p-arg230trp-mutation
#39
JOURNAL ARTICLE
Yan Wang, Chuanfei Wei, Yanming Liu, Xianjie Lu, Wei Wang, Na Song, Wei Zhang, Jun Xu, Wei Zhang, Fabin Han
Parkinson's disease (PD) is a highly prevalent and severe neurodegenerative disease that affects more than 10 million individuals worldwide. Pathogenic mutations in LRP10 have been associated with autosomal dominant PD. Here, we report an induced pluripotent stem cell (iPSC) line generated from a PD patient harboring the LRP10 c.688C > T (p.Arg230Trp) variant. Skin fibroblasts from the PD patient were successfully reprogrammed into iPSCs that expressed pluripotency markers, a normal karyotype, and the capacity to differentiate into the three germ layers in vivo...
March 3, 2024: Stem Cell Research
https://read.qxmd.com/read/38459853/the-rejuvenation-and-functional-restoration-of-aged-adipose-stem-cells-by-duxap10-knockdown-via-the-regulation-of-the-mir-214-3p-rassf5-axis
#40
JOURNAL ARTICLE
Sen Ren, Chengcheng Li, Hewei Xiong, Qian Wu, Xiaohui Wu, Zhongwei Xiong, Lixing Dong, Bing Shu, Wei Wei, Chao Ma, Xiang Li, Jincao Chen
Adipose stem cell (ASC)-based therapies provide an encouraging option for tissue repair and regeneration. However, the function of these cells declines with aging, which limits their clinical transformation. Recent studies have outlined the involvement of long non-coding RNAs in stem cell aging. Here, we reanalyzed our published RNA sequencing (RNA-seq) data profiling differences between ASCs from young and old donors and identified a lncRNA named double homeobox A pseudogene 10 (DUXAP10) as significantly accumulated in aged ASCs...
March 9, 2024: Stem Cells Translational Medicine
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