keyword
https://read.qxmd.com/read/38534926/haploidentical-hematopoietic-stem-cell-transplantation-for-patients-with-severe-aplastic-anemia-single-centre-experience
#1
Vered Stavi, Niranjan Khaire, Jeffrey H Lipton, Rajat Kumar
Severe aplastic anemia (SAA) is a life-threatening type of aplastic anemia for which allogeneic stem cell transplantation or immunosuppressive therapy are the principal treatment modalities. Only about 25-30% of patients have a matched sibling donor, and finding an unrelated donor in ethnic minorities is a challenge. The use of related haploidentical donor transplants in severe aplastic anemia is uncommon. We would like to report our experience with the first four patients who underwent haploidentical transplants for severe aplastic anemia...
February 26, 2024: Current Oncology
https://read.qxmd.com/read/38534508/contractile-and-genetic-characterization-of-cardiac-constructs-engineered-from-human-induced-pluripotent-stem-cells-modeling-of-tuberous-sclerosis-complex-and-the-effects-of-rapamycin
#2
JOURNAL ARTICLE
Veniamin Y Sidorov, Tatiana N Sidorova, Philip C Samson, Ronald S Reiserer, Clayton M Britt, M Diana Neely, Kevin C Ess, John P Wikswo
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38532843/novel-design-and-development-of-centella-asiatica-extract-loaded-poloxamer-zno-nanocomposite-wound-closure-material-to-improve-anti-bacterial-action-and-enhanced-wound-healing-efficacy-in-diabetic-foot-ulcer
#3
JOURNAL ARTICLE
Lina Wang, Yan Yang, Weiwei Han, Hui Ding
Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation. The cause and effect of diabetic foot ulcer is complex, involving multiple factors. In the present study, wound healing strategies utilizing nanomaterials have proven to be effective in battling bacterial infections and improve wound regeneration. Poloxamers (PLX) exhibit extensive potential as a viable option for the development of nanomedicines owing to their inherent characteristics of self-assembly and encapsulation...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38531230/generation-and-characterization-of-an-ips-cell-line-pumci006-a-from-skin-fibroblasts-of-a-patient-with-an-m239t-mutation-in-psen2-gene
#4
JOURNAL ARTICLE
Wanwan Zhu, Jinjuan Zhou, Li Shang, You Zhou, Qingyu Wang, Yuesong Yu, Liling Dong, Chenhui Mao, Shanshan Chu, Wei Jin, Jie Li, Jing Gao
Presenilin-2 (PSEN2) mutation is one of the pathogenic factors of autosomal dominant early-onset Alzheimer's disease (EOAD). We generated a human induced pluripotent stem cell (iPSC) line from fibroblasts of an EOAD patient carrying PSEN2 mutation (c.716 T > C) utilizing Sendai reprogramming kit. The resulting iPSC line carried patient-specific point mutation, exhibited typical iPSC morphology, retained a normal karyotype, expressed pluripotency markers, and could form embryoid bodies. Established iPSC line serve as valuable resource for EOAD disease pathogenesis modelling and drug screening...
March 14, 2024: Stem Cell Research
https://read.qxmd.com/read/38528631/head-and-neck-cancer-of-unknown-primary-unveiling-primary-tumor-sites-through-machine-learning-on-dna-methylation-profiles
#5
JOURNAL ARTICLE
Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter, Markus Wirth
BACKGROUND: The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype, squamous cell carcinoma, can stem from various tumor primary sites, including the oral cavity, oropharynx, larynx, head and neck skin, lungs, and esophagus. DNA methylation profiles are highly tissue-specific and have been successfully used to classify tissue origin...
March 25, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38524394/autologous-nanofat-injection-combined-with-fractional-co2-laser-in-the-treatment-of-atrophic-acne-scars
#6
JOURNAL ARTICLE
Mahmoud A Rageh, Shady Mahmoud Attia Ibrahim, Noha Abdallah, Abeer Attia Tawfik
BACKGROUND: Atrophic acne scarring is a widely prevalent condition and one of the most distressing complications of acne vulgaris. Numerous options with variable outcomes are available for the treatment of acne scarring. Laser is considered a first-line therapy for acne scars, and recently there has been a growing interest in using stem cells and their derivatives for treating acne scars. In addition, combined therapeutic modalities often achieve more satisfactory results than a single treatment...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38524392/human-mesenchymal-stem-cell-derived-exosomes-promote-the-proliferation-and-melanogenesis-of-primary-melanocytes-by-attenuating-the-h-2-o-2-related-cytotoxicity-in-vitro
#7
JOURNAL ARTICLE
Yexiao Wang, Zibin He, Bingqin Luo, Hioteng Wong, Liangcai Wu, Hui Zhou
BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-Exo) have therapeutic potential. However, the impact of MSC-Exo on the survival and melanogenesis of human primary melanocytes following H2 O2 -induced damage has not been clarified. We therefore investigated the effects of MSC-Exo on the H2 O2 -affected survival of human primary melanocytes and their proliferation, apoptosis, senescence, and melanogenesis in vitro. METHODS: MSC-Exo were prepared from human MSCs by sequential centrifugations and characterized by Transmission Electron Microscopy, Western blot and Nanoparticle Tracking Analysis...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38522856/severe-liver-dysfunction-after-donor-lymphocyte-infusion-for-relapsed-multiple-myeloma
#8
Tae-Hoon No, Nae-Yun Heo, Seung Ha Park, Joon Hyuk Choi, Junghwan Lee, Sung Nam Lim, Seon Yang Park
Donor lymphocyte infusion (DLI) is performed to augment an anti-tumor immune response or ensure donor stem cells remain engrafted following allogeneic stem cell transplantation but may induce graft-versus-host disease (GVHD) involving skin, intestine, and liver. Although hepatic involvement of GVHD can manifest as mild to severe hepatitis, few reports have mentioned acute severe liver dysfunction with encephalopathy. We experienced a case of acute severe liver dysfunction with semicoma after DLI in a patient with relapsed multiple myeloma following allogeneic stem cell transplantation, in whom chronic viral hepatitis B had been suppressed by antiviral treatment...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38521740/sequential-transplantation-of-exosomes-and-bmscs-pretreated-with-hypoxia-efficiently-facilitates-perforator-skin-flap-survival-area-in-rats
#9
JOURNAL ARTICLE
Jin-Ping Ding, Yan Sun, Bo Chen, Wen-Jiang Qian, Shi-Wei Bao, Hong-Yi Zhao
Bone marrow mesenchymal stem cells (BMSC) are promising candidates for the treatment of trans-territory perforator flap necrosis. However, the low retention and survival rate of engrafted BMSCs limit their therapeutic efficacy. Strategies either modifying BMSCs or alleviating the inflammatory environment may solve this problem. Thus, we aimed to explore the therapeutic efficacy of sequential transplantation of exosomes and hypoxia pretreated BMSCs on flap necrosis. After the perforator flap model was created, the exosomes derived from BMSCs were injected immediately into choke zone II followed by transplantation of hypoxia pretreated BMSCs on Day 2...
December 28, 2023: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#10
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38519574/activated-fibroblasts-modify-keratinocyte-stem-niche-through-tet1-and-il-6-to-promote-their-rapid-transformation-in-a-mouse-model-of-prenatal-arsenic-exposure
#11
JOURNAL ARTICLE
Anchal Chauhan, Siddhartha Gangopadhyay, Kavita Koshta, Sukhveer Singh, Dhirendra Singh, Vikas Srivastava
Early life exposure to environmental pollutants such as arsenic (As) can increase the risk of cancers in the offspring. In an earlier study, we showed that only prenatal As exposure significantly increases epidermal stem cell proliferation and accelerates skin tumorigenesis in BALB/c mouse offspring. In the present work, we have examined the role of As-conditioned dermal fibroblasts (DFs) in creating pro-tumorigenic niches for Keratinocyte stem cells (KSCs) in the offspring. DFs isolated from prenatally exposed animals showed increased levels of activation markers (α-SMA, Fibronectin, Collagen IV), induction of ten-eleven translocation methylcytosine dioxygenase 1(TET1), and secreted high levels of niche modifying IL-6...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38516531/extracellular-vesicles-derived-from-mesenchymal-stem-cells-the-wine-in-hebe-s-hands-to-treat-skin-aging
#12
REVIEW
Qixiang Gui, Neng Ding, Zuochao Yao, Minjuan Wu, Ruifeng Fu, Yue Wang, Yunpeng Zhao, Lie Zhu
Owing to its constant exposure to the external environment and various stimuli, skin ranks among the organs most vulnerable to manifestations of aging. Preventing and delaying skin aging has become one of the prominent research subjects in recent years. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from mesoderm with high self-renewal ability and multilineage differentiation potential. MSC-derived extracellular vesicles (MSC-EVs) are nanoscale biological vesicles that facilitate intercellular communication and regulate biological behavior...
March 2024: Precision Clinical Medicine
https://read.qxmd.com/read/38515315/combined-amniotic-membrane-and-self-powered-electrical-stimulator-bioelectronic-dress-promotes-wound-healing
#13
JOURNAL ARTICLE
Yupei Wang, Han Wu, Ao Xiao, Jing Zhu, Jie Qiu, Kuan Yang, Qing Liu, Shengju Hao, Ling Hui, Xin Zhou, Qinzheng Hou, Haixiang Su, Zhaoyan Meng, Lingqian Chang
Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells...
March 21, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38510961/the-cutaneous-beta-human-papillomavirus-type-8-e6-protein-induces-ccl2-through-the-cebp%C3%AE-mir-203-p63-pathway-to-support-an-inflammatory-microenvironment-in-epidermodysplasia-verruciformis-skin-lesions
#14
JOURNAL ARTICLE
Luca Vella, Anna Sternjakob, Stefan Lohse, Alina Fingerle, Tanya Sperling, Claudia Wickenhauser, Michael Stöckle, Thomas Vogt, Klaus Roemer, Monika Ołdak, Sigrun Smola
Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). We had previously shown that Langerhans cells responsible for epithelial immunosurveillance were strongly reduced at infected sites and that the HPV8 E7 protein interferes with the CCAAT/enhancer-binding protein (C/EBP)β to suppress the Langerhans cell chemokine CCL20. At the same time, however, we observed that EV lesions are heavily infiltrated with inflammatory immune cells, which is similar to the situation in HPV8 E6 transgenic mice...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38509633/patients-with-systemic-sclerosis-and-low-cd4-numbers-after-autologous-stem-cell-transplantation-have-a-favorable-outcome
#15
JOURNAL ARTICLE
Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke, Joerg Christoph Henes
BACKGROUND: Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment option for patients with severe forms of systemic sclerosis (SSc). Even though associated with a high treatment related mortality, the results in this high-risk population are generally favourable. The knowledge on the potential mechanism of action of this therapy and how it can improve patients with SSc is crucial to better select the right patients for aHSCT...
March 20, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38507883/generation-of-a-human-embryonic-stem-cell-line-smudhe010-a-1a-carrying-brainbow-cassette-in-the-aavs1-gene-by-crispr-cas9-mediated-homologous-recombination
#16
JOURNAL ARTICLE
Yingying Luo, Wen Zheng, Yadang Zhong, Huiting Liu, Jing Yu, Biying Qiu, Jun Liu, Bin Yang
Tracking single-cell lineages and their phenotypes longitudinally would help us better study skin development. Brainbow multicolor labeling approach is a genetic cell-labeling technique that tracks individual cells or analyzes cell lineages during development. Hence, we generated a stable Cre-inducible rainbow reporter human embryonic stem cell line (Named SMUDHe010-A-1A) by inserting the fluorescent protein gene (nGFP, YFP, RFP and CFP) at AAVS1 safe harbor locus using CRISPR/Cas9 technology. We verified that SMUDHe010-A-1A expressed the pluripotency markers and showed normal stem cell morphology...
March 11, 2024: Stem Cell Research
https://read.qxmd.com/read/38506587/the-management-of-chronic-graft-versus-host-disease-skin-ulcers-after-hematopoietic-stem-cell-transplantation-a-case-report
#17
JOURNAL ARTICLE
Yi Chen, XueHua Zhao, Xun Wang, Lai Juan Li, LinZhu Wu
The comprehensive management of a patient with chronic graft-versus-host disease skin ulcers after hematopoietic stem cell transplantation is challenging. This report describes the case of a 53-year-old woman who presented with ulcers on her right leg 140 weeks after a bone marrow transplant. The patient received wound assessment and management based on the Triangle of Wound Assessment and Wound Bed Preparation 2021, respectively. Hydrogel and antibacterial protease dressings were applied along with systemic oral administration of moxifloxacin hydrochloride (two capsules, two times daily) and JiXueGanPian tablets (classic Chinese herbal formula; two capsules, two times daily), hospital-community-home continuous care, and patient-centered education...
April 1, 2024: Advances in Skin & Wound Care
https://read.qxmd.com/read/38500227/correction-evaluation-of-secretomes-derived-from-human-dermal-and-adipose-tissue-mesenchymal-stem-stromal-cells-for-skin-wound-healing-not-as-effective-as-cells
#18
Helena Debiazi Zomer, Victor Juan de Souza Lima, Monique Coelho Bion, Karynne Nazare Lins Brito, Michele Rode, Marco Augusto Stimamiglio, Talita da Silva Jeremias, Andrea Gonçalves Trentin
No abstract text is available yet for this article.
March 18, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38494614/an-atlas-of-the-human-nail
#19
JOURNAL ARTICLE
Nardo Zaias
Dermatologic literature describes nail abnormalities involving nail bed as linear erythronychia or onychomatricoma. The abnormality reflects cognitive content of the nail bed. A resourceful epidermis capable of manifesting in a variety of clinical appearances depends on initiating stimulus affecting remarkably its nail bed matrix cells. These cells are stem cells (NBMSC) migrating distally to cover remarkably the underlying nail bed dermal ridges that are homologous to finger print dermal ridges. Normally, adult nail bed epidermal cells are uniform and keratinize with the stratum corneum without a granular layer...
2024: Skinmed
https://read.qxmd.com/read/38494294/hematologic-malignancies-and-hematopoietic-stem-cell-transplantation
#20
REVIEW
Chiara Briani, Andrea Visentin
Paraneoplastic neurologic syndromes are rarely associated with hematologic malignancies. In their rarity, lymphomas are the diseases with more frequent paraneoplastic neurologic syndrome. High-risk antibodies are absent in most lymphoma-associated paraneoplastic neurologic syndromes, with the exception of antibodies to Tr/DNER in paraneoplastic cerebellar degeneration, mGluR5 in limbic encephalitis, and mGluR1 in some cerebellar ataxias. Peripheral nervous system paraneoplastic neurologic syndromes are rare and heterogeneous, with a prevalence of demyelinating polyradiculoneuropathy in non-Hodgkin lymphoma...
2024: Handbook of Clinical Neurology
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