Suzhen Lin, André D G Leitão, Savannah Fang, Yingli Gu, Sophia Barber, Rhiannon Gilliard-Telefoni, Alfredo Castro, Kijung Sung, Ruinan Shen, Jazmin B Florio, Michael L Mante, Jianqing Ding, Brian Spencer, Eliezer Masliah, Robert A Rissman, Chengbiao Wu
Mutations or triplication of the alpha synuclein (ASYN) gene contribute to synucleinopathies including Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent evidence suggests that ASYN also plays an important role in amyloid-induced neurotoxicity, although the mechanism(s) remains unknown. One hypothesis is that accumulation of ASYN alters endolysosomal pathways to impact axonal trafficking and processing of the amyloid precursor protein (APP). To define an axonal function for ASYN, we used a transgenic mouse model of synucleinopathy that expresses a GFP-human ASYN (GFP-hASYN) transgene and an ASYN knockout (ASYN-/- ) mouse model...
January 23, 2023: Neurobiology of Disease