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https://www.readbyqxmd.com/read/28632829/-advances-in-dengue-virus-research-in-colombia-the-role-of-cellular-micrornas-as-an-anti-dengue-virus-response
#1
Juan Camilo Castrillón-Betancur, Silvio Urcuqui-Inchima
Dengue is one of the most important mosquito-borne diseases, and its incidence has increased at an alarming rate in recent years, becoming a real public health problem. Currently, there is no vaccine or medication or proper treatment for dengue control. Considering this situation, it is necessary to prioritize the search for new alternatives and strategies for dengue prevention and control, in order to reduce not only the economic burden of endemic countries, but also to improve the quality of life of patients...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28620811/serological-molecular-and-clinical-correlates-of-dengue-from-a-tertiary-care-centre-in-chennai-india
#2
Vigna Seshan, Gopalsamy Sarangan, Khaleefathullah Sheriff, Kaveri Krishnasamy, Gunasekaran Palani, Padma Srikanth
Dengue disease is caused by dengue viruses 1-4 and has been ranked by the World Health Organisation (WHO) as the fastest spreading vector-borne viral disease. Dengue is often underreported and misdiagnosed due to a wide spectrum of clinical manifestations. Diagnosis of dengue is based on clinical case definitions and laboratory methods. Newer case definitions of dengue have been formulated by clinical studies in order to improve case detection. Owing to its epidemic potential, mortality and morbidity, there is a need for a rapid and accurate diagnostic assay for dengue in order to help the clinician in the early detection of cases and to prevent disease progression...
June 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28614803/delineating-antibody-recognition-against-zika-virus-during-natural-infection
#3
Lei Yu, Ruoke Wang, Fei Gao, Min Li, Jianying Liu, Jian Wang, Wenxin Hong, Lingzhai Zhao, Yingfen Wen, Chibiao Yin, Hua Wang, Qi Zhang, Yangyang Li, Panpan Zhou, Rudian Zhang, Yang Liu, Xiaoping Tang, Yongjun Guan, Cheng-Feng Qin, Ling Chen, Xuanling Shi, Xia Jin, Gong Cheng, Fuchun Zhang, Linqi Zhang
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that shares a considerable degree of homology with dengue virus (DENV). Here, we examined longitudinal antibody response against ZIKV during natural infection in 2 convalescent individuals. By decomposing the antibody recognition into DI/DII and DIII of the E glycoprotein, we showed their development in humans followed a spatiotemporal hierarchy. Plasma binding to DI/DII appeared to peak and wane during early infection with extensive cross-reactivity with DI/DII of DENV...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28612239/dengue-hemorrhagic-fever-a-state-of-the-art-review-focused-in-pulmonary-involvement
#4
REVIEW
Renata Rocha de Almeida, Bernardo Paim, Solange Artimos de Oliveira, Arthur Soares Souza, Antônio Carlos Portugal Gomes, Dante Luiz Escuissato, Gláucia Zanetti, Edson Marchiori
Dengue fever is an arboviral disease transmitted to humans through the bites of infected female Aedes mosquitoes. Dengue virus is a member of the Flaviviridae family, and human infection can be caused by any of the four antigenically distinct serotypes (DENV 1-4). The infection has become recognized as the most important and prevalent arboviral disease in humans, endemic in almost 100 countries worldwide. Nearly 3 billion people live in areas with transmission risk. Autochthonous transmission of the virus in previously disease-free areas, increased incidence in endemic areas, and epidemic resurgence in controlled regions could increase the risk of contracting more severe forms of the disease, such as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
June 13, 2017: Lung
https://www.readbyqxmd.com/read/28611867/a-comparative-study-of-the-trends-of-imported-dengue-cases-in-korea-and-japan-2011-2015
#5
Shinichiro Miki, Won-Chang Lee, Myeong-Jin Lee
BACKGROUND: Dengue is a mosquito-borne febrile disease that represents a major public health problem in tropical and subtropical areas. Even though Korea and Japan are not the regions where dengue is epidemic, there have been many imported cases in both countries, and in increasing numbers. A better understanding of the characteristics of the prevalence of dengue and the recent trends in these neighboring countries may provide information to promote improvement and control strategies for both...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28607237/sustainable-dengue-prevention-and-control-through-a-comprehensive-integrated-approach-the-sri-lankan-perspective
#6
Hasitha Tissera, Nimalka Pannila-Hetti, Preshila Samaraweera, Jayantha Weeraman, Paba Palihawadana, Ananda Amarasinghe
Dengue is a leading public health problem in Sri Lanka. All 26 districts and all age groups are affected, with high disease transmission; the estimated average annual incidence is 175/100 000 population. Harnessing the World Health Organization Global strategy for dengue prevention and control, 2012-2020, Sri Lanka has pledged in its National Strategic Framework to achieve a mortality from dengue below 0.1% and to reduce morbidity by 50% (from the average of the last 5 years) by 2020. Turning points in the country's dengue-control programme have been the restructuring and restrategizing of the core functions; this has involved establishment of a separate dengue-control unit to coordinate integrated vector management, and creation of a presidential task force...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28604797/a-human-inferred-germline-antibody-binds-to-an-immunodominant-epitope-and-neutralizes-zika-virus
#7
Diogo M Magnani, Cassia G T Silveira, Brandon C Rosen, Michael J Ricciardi, Núria Pedreño-Lopez, Martin J Gutman, Varian K Bailey, Helen S Maxwell, Aline Domingues, Lucas Gonzalez-Nieto, Vivian I Avelino-Silva, Mateus Trindade, Juliana Nogueira, Consuelo S Oliveira, Alvino Maestri, Alvina Clara Felix, José Eduardo Levi, Mauricio L Nogueira, Mauricio A Martins, José M Martinez-Navio, Sebastian P Fuchs, Stephen S Whitehead, Dennis R Burton, Ronald C Desrosiers, Esper G Kallas, David I Watkins
The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut50 ~ 2 μg/ml) but did not react with any of the four dengue virus serotypes...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28599678/the-prevalence-of-dengue-virus-serotypes-in-asymptomatic-blood-donors-reveals-the-emergence-of-serotype-4-in-saudi-arabia
#8
Ahmed Mohamed Ashshi
BACKGROUND: Transmission of dengue virus (DENV) through blood transfusion has been documented and hence screening for DENV during blood donation has been recently recommended by the American Association of Blood Banks and Centres of Disease Control and Prevention. DENV is endemic in the Western province of the Kingdom of Saudi Arabia (KSA) and serotypes 1, 2 and 3, but not 4, have been detected. However, little is known regarding the rates of DENV during blood donation in the kingdom...
June 9, 2017: Virology Journal
https://www.readbyqxmd.com/read/28598047/awareness-and-outcome-of-changing-trends-in-clinical-profile-of-dengue-fever-a-retrospective-analysis-of-dengue-epidemic-from-january-to-december-2014-at-a-tertiary-care-hospital
#9
Jitendra Singh, Anju Dinkar, Virendra Atam, D Himanshu, Kamlesh Kumar Gupta, Kauser Usman, Ravi Misra
BACKGROUND: Dengue fever is caused by mosquito-borne arboviral infection that has become a public health concern globally. Recently, an alarming rise of dengue has also been seen in India. Hence the study was undertaken to know profile of clinical manifestations and laboratory findings during the evolution of dengue fever. METHODS: In this study, retrospective data analysis was done in 216 seropositive dengue patients admitted between January to December 2014 in department of medicine at a north Indian care hospital...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28596655/a-correlation-of-the-platelet-count-with-d-dimer-levels-as-an-indicator-for-component-therapy-in-children-with-dengue-hemorrhagic-fever
#10
Arthi Sridhar, B M Sunil Kumar, Aarathi Rau, A T K Rau
Dengue Fever (DF) may evolve into two life threatening forms-Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). DHF is associated with increased vascular permeability and plasma leakage causing thrombocytopenia and loss of clotting factors into the third space and may result in bleeding initially due to thrombocytopenia and later due to disseminated intravascular coagulation (DIC), often as a terminal event. Prompt recognition and treatment of minor bleeds in DF children with incipient DIC with component therapy may be associated with improved survival while failure to do so is usually catastrophic...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28590795/a-recombinant-live-attenuated-tetravalent-vaccine-for-the-prevention-of-dengue
#11
Bruno Guy, Fernando Noriega, R Leon Ochiai, Maïna L'azou, Valentine Delore, Anna Skipetrova, François Verdier, Laurent Coudeville, Stephen Savarino, Nicholas Jackson
Dengue is an important and still growing public health problem associated with substantial morbidity, as well as significant social and economic impact. The present review describes the main features and development of the first dengue vaccine (CYD-TDV, Dengvaxia®), which has been licensed by several dengue-endemic countries in Asia and Latin America for use in populations above 9 years of age. Areas covered: The review focuses on the large clinical development of CYD-TDV, which includes in particular two pivotal phase III efficacy trials conducted in Asia and Latin America and supported vaccine licensure...
July 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28586575/and-yet-one-more-adds-to-the-sorrow
#12
EDITORIAL
Muhammad Zeeshan Haroon, Mohammad Salim Wazir
Chikungunya is one of the vector borne diseases. It is caused by Chikungunya virus, an alpha virus, spread by the bite of female Aedes mosquito. Chikungunya is a non-fatal, self-limiting Dengue like illness which is characterized by high grade fever, headache, skin rash, and prolong debilitating arthralgia mostly affecting peripheral small joints. Treatment is usually supportive for the symptoms which includes antipyretic, analgesics and anti-inflammatory drugs. Current outbreak in Karachi is the first declared outbreak in Pakistan...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28577363/international-workshop-on-insecticide-resistance-in-vectors-of-arboviruses-december-2016-rio-de-janeiro-brazil
#13
Vincent Corbel, Dina M Fonseca, David Weetman, João Pinto, Nicole L Achee, Fabrice Chandre, Mamadou B Coulibaly, Isabelle Dusfour, John Grieco, Waraporn Juntarajumnong, Audrey Lenhart, Ademir J Martins, Catherine Moyes, Lee Ching Ng, Kamaraju Raghavendra, Hassan Vatandoost, John Vontas, Pie Muller, Shinji Kasai, Florence Fouque, Raman Velayudhan, Claire Durot, Jean-Philippe David
Vector-borne diseases transmitted by insect vectors such as mosquitoes occur in over 100 countries and affect almost half of the world's population. Dengue is currently the most prevalent arboviral disease but chikungunya, Zika and yellow fever show increasing prevalence and severity. Vector control, mainly by the use of insecticides, play a key role in disease prevention but the use of the same chemicals for more than 40 years, together with the dissemination of mosquitoes by trade and environmental changes, resulted in the global spread of insecticide resistance...
June 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28560654/newer-vaccines-against-mosquito-borne-diseases
#14
Anju Aggarwal, Neha Garg
Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P...
May 31, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28558804/metofluthrin-investigations-into-the-use-of-a-volatile-spatial-pyrethroid-in-a-global-spread-of-dengue-chikungunya-and-zika-viruses
#15
Tamara S Buhagiar, Gregor J Devine, Scott A Ritchie
BACKGROUND: Metofluthrin reduces biting activity in Aedes aegypti through the confusion, knockdown, and subsequent kill of a mosquito. A geographical spread in dengue, chikungunya, and Zika viruses, increases intervention demands. Response to a Zika outbreak may require a different strategy than dengue, as high-risk individuals, specifically pregnant women, need to be targeted. METHODS: In semi-field conditions within a residential property in Cairns, Queensland, the impacts of metofluthrin on biting behaviour of free-flying Wolbachia-infected Ae...
May 30, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28556417/dengue-data-and-surveillance-in-tanzania-a-systematic-literature-review
#16
REVIEW
Tara Ward, Moody Samuel, Dorit Maoz, Silvia Runge-Ranzinger, Ross Boyce, Joao Toledo, Raman Velayudhan, Olaf Horstick
OBJECTIVE: Although there is evidence that dengue virus is circulating in Tanzania, the country lacks a dengue surveillance system. Consequently, the true estimate of dengue seroprevalence, as well as the incidence in the population, the frequency and magnitude of outbreaks is unknown. This study therefore sought to systematically review available dengue data from Tanzania. METHODS: The systematic review was conducted and reported using the PRISMA tool. Five databases (PubMed, EMBASE, Web of Science, WHOLIS and Google Scholar) were searched for articles using variations of keywords on the illness, data and geographical location...
May 28, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28552190/spatial-mapping-of-temporal-risk-to-improve-prevention-measures-a-case-study-of-dengue-epidemic-in-lahore
#17
Sidrah Hafeez, Muhammad Amin, Bilal Ahmed Munir
BACKGROUND: Dengue is identified as serious vector born infectious disease by WHO, threating around 2.5 billion people around the globe. Pakistan is facing dengue epidemic since 1994 but 2010 and 2011 dengue outbreaks were worst. During 2011 dengue outbreak 22,562 cases were reported and 363 died due to this fatal infection in Pakistan. In this study, Lahore District was chosen as it was severely affected in 2011 dengue outbreak with 14,000 reported cases and 300 deaths. There is no vaccine developed yet for the disease control, so only effective early warning, prevention and control measures can reduce the potential disease risk...
June 2017: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/28536674/anti-idiotypic-antibodies-specific-to-prm-monoantibody-prevent-antibody-dependent-enhancement-of-dengue-virus-infection
#18
Miao Wang, Fan Yang, Dana Huang, Yalan Huang, Xiaomin Zhang, Chao Wang, Shaohua Zhang, Renli Zhang
Dengue virus (DENV) co-circulates as four serotypes (DENV1-4). Primary infection only leads to self-limited dengue fever. But secondary infection with another serotype carries a higher risk of increased disease severity, causing life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Serotype cross-reactive antibodies facilitate DENV infection in Fc-receptor-bearing cells by promoting virus entry via Fcγ receptors (FcγR), a process known as antibody dependent enhancement (ADE). Most studies suggested that enhancing antibodies were mainly specific to the structural premembrane protein (prM) of DENV...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28536430/aetiology-of-acute-meningoencephalitis-in-cambodian-children-2010-2013
#19
Paul F Horwood, Veasna Duong, Denis Laurent, Channa Mey, Heng Sothy, Ky Santy, Beat Richner, Seiha Heng, Sopheak Hem, Justine Cheval, Christopher Gorman, Philippe Dussart, Menno D de Jong, Alexandra Kerleguer, Bertrand Guillard, Bernadette Murgue, Marc Lecuit, Xavier de Lamballerie, Jeremy J Farrar, Arnaud Tarantola, Marc Eloit, Philippe Buchy
Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV)...
May 24, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#20
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
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