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https://www.readbyqxmd.com/read/28736678/rapid-assessment-zika-virus-knowledge-among-clinical-specialists-in-singapore-a-cross-sectional-survey
#1
Chee F Yung, Clarence C Tam, Victor S Rajadurai, Jerry Ky Chan, Mabel Sf Low, Yong H Ng, Koh C Thoon, Lay K Tan
INTRODUCTION: We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore. METHODS: Between June 6 and June 19, 2016 we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. The survey included 15 multiple choice questions to measure respondents' knowledge of Zika virus in four domains covering clinical and public health. RESULTS: A total of 110 survey responses (15% response rate) were obtained, 82% of respondents worked in the public sector...
May 3, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28722613/why-did-zika-not-explode-in-cuba-the-role-of-active-community-participation-to-sustain-control-of-vector-borne-diseases
#2
Marta Castro, Dennis Perez, Maria G Guzman, Clare Barrington
As the global public health community develops strategies for sustainable Zika prevention and control, assessment of the Cuban response to Zika provides critical lessons learned. Cuba's early and successful response to Zika, grounded in the country's long-standing dengue prevention and control program, serves as a model of rapid mobilization of intersectoral efforts. Sustaining this response requires applying the evidence generated within the Cuban dengue program that active community participation improves outcomes and is sustainable and cost-effective...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721101/survey-of-malaria-and-anti-dengue-virus-igg-among-febrile-hiv-infected-patients-attending-a-tertiary-hospital-in-abuja-nigeria
#3
Jelili Olaide Mustapha, Anthony Uchenna Emeribe, Idris Abdullahi Nasir
BACKGROUND: Dengue and malaria are infections, of great public health concern, especially in sub-Saharan Africa where the burden of HIV infection is high. This study was conducted to determine the seroprevalence of dengue virus IgG antibodies and dengue/malaria coinfection among febrile HIV-infected patients attending the University of Abuja Teaching Hospital, Gwagwalada, Abuja. METHODS: In this cross-sectional study, blood samples from 178 consenting HIV-infected patients receiving antiretroviral therapy were collected and tested for plasmodiasis and anti-Dengue virus IgG using malaria microscopy and ELISA, respectively...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/28716893/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-there-is-only-one-true-winner
#4
Scott B Halstead
The scientific community now possesses information obtained directly from human beings that makes it possible to understand why breakthrough-enhanced dengue virus (DENV) infections occurred in children receiving Sanofi Pasteur's Dengvaxia tetravalent live attenuated vaccine and to predict the possibility of breakthrough-enhanced DENV infections following immunization with two other tetravalent live attenuated vaccines now in phase III testing. Based upon recent research, Dengvaxia, lacking DENV nonstructural protein antigens, did not protect seronegatives because it failed to raise a competent T-cell response and/or antibodies to NS1...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28715426/community-effectiveness-of-pyriproxyfen-as-a-dengue-vector-control-method-a-systematic-review
#5
Dorit Maoz, Tara Ward, Moody Samuel, Pie Müller, Silvia Runge-Ranzinger, Joao Toledo, Ross Boyce, Raman Velayudhan, Olaf Horstick
BACKGROUND: Vector control is the only widely utilised method for primary prevention and control of dengue. The use of pyriproxyfen may be promising, and autodissemination approach may reach hard to reach breeding places. It offers a unique mode of action (juvenile hormone mimic) and as an additional tool for the management of insecticide resistance among Aedes vectors. However, evidence of efficacy and community effectiveness (CE) remains limited. OBJECTIVE: The aim of this systematic review is to compile and analyse the existing literature for evidence on the CE of pyriproxyfen as a vector control method for reducing Ae...
July 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28713027/an-on-matrix-digestion-procedure-for-ap-ms-experiments-dissects-the-interplay-between-complex-conserved-and-serotype-specific-reactivities-in-dengue-virus-human-plasma-interactome
#6
Yassel Ramos, Vivian Huerta, Dayron Martín, Sucel Palomares, Alexis Yero, Dianne Pupo, Sebastien Gallien, Alejandro M Martín, Yasset Pérez-Riverol, Mónica Sarría, Osmany Guirola, Glay Chinea, Bruno Domon, Luis Javier González
The interactions between the four Dengue virus (DENV) serotypes and plasma proteins are crucial in the initial steps of viral infection to humans. Affinity purification combined with quantitative mass spectrometry analysis, has become one of the most powerful tools for the investigation on novel protein-protein interactions. Using this approach, we report here that a significant number of bait-interacting proteins do not dissociate under standard elution conditions, i.e. acid pH and chaotropic agents, and that this problem can be circumvented by using the "on-matrix" digestion procedure described here...
July 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28712416/biopsychosocial-risk-factors-of-persistent-fatigue-after-acute-infection-a-systematic-review-to-inform-interventions
#7
REVIEW
Katrin Hulme, Joanna L Hudson, Philine Rojczyk, Paul Little, Rona Moss-Morris
OBJECTIVES: Fatigue is a prevalent and debilitating symptom, preceded by an acute infectious episode in some patients. This systematic review aimed to identify risk factors for the development of persistent fatigue after an acute infection, to develop an evidence-based working model of post-infectious fatigue. METHODS: Electronic databases (Medline, PsycINFO and EMBASE) were searched, from inception to March 2016, for studies which investigated biopsychosocial risk factors of on-going fatigue after an acute infection...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28707486/working-towards-dengue-as-a-vaccine-preventable-disease-challenges-and-opportunities
#8
Ambuj Shrivastava, Nagesh K Tripathi, Paban K Dash, Manmohan Parida
Dengue is an emerging viral disease that affects the human population around the globe. Recent advancements in dengue virus research have opened new avenues for the development of vaccines against dengue. The development of a vaccine against dengue is a challenging task because any of the four serotypes of dengue viruses can cause disease. The development of a dengue vaccine aims to provide balanced protection against all the serotypes. Several dengue vaccine candidates are in the developmental stages such as inactivated, live attenuated, recombinant subunit, and plasmid DNA vaccines...
July 24, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28701194/characterization-and-productivity-profiles-of-aedes-aegypti-l-breeding-habitats-across-rural-and-urban-landscapes-in-western-and-coastal-kenya
#9
Harun N Ngugi, Francis M Mutuku, Bryson A Ndenga, Peter S Musunzaji, Joel O Mbakaya, Peter Aswani, Lucy W Irungu, Dunstan Mukoko, John Vulule, Uriel Kitron, Angelle D LaBeaud
BACKGROUND: Aedes aegypti, the principal vector for dengue and other emerging arboviruses, breeds preferentially in various man-made and natural container habitats. In the absence of vaccine, epidemiological surveillance and vector control remain the best practices for preventing dengue outbreaks. Effective vector control depends on a good understanding of larval and adult vector ecology of which little is known in Kenya. In the current study, we sought to characterize breeding habitats and establish container productivity profiles of Ae...
July 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28699570/camino-verde-the-green-way-evidence-based-community-mobilisation-for-dengue-control-in-nicaragua-and-mexico-feasibility-study-and-study-protocol-for-a-randomised-controlled-trial
#10
Neil Andersson, Jorge Arostegui, Elizabeth Nava-Aguilera, Eva Harris, Robert J Ledogar
BACKGROUND: Since the Aedes aegypti mosquitoes that transmit dengue virus can breed in clean water, WHO-endorsed vector control strategies place sachets of organophosphate pesticide, temephos (Abate), in household water storage containers. These and other pesticide-dependent approaches have failed to curb the spread of dengue and multiple dengue virus serotypes continue to spread throughout tropical and subtropical regions worldwide. A feasibility study in Managua, Nicaragua, generated instruments, intervention protocols, training schedules and impact assessment tools for a cluster randomised controlled trial of community-based approaches to vector control comprising an alternative strategy for dengue prevention and control in Nicaragua and Mexico...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699565/household-costs-of-dengue-illness-secondary-outcomes-from-a-randomised-controlled-trial-of-dengue-prevention-in-guerrero-state-mexico
#11
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de Los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue illness. It examined the economic impact of the trial intervention in the three coastal regions of Mexico's Guerrero State. METHODS: The 2010 baseline survey covered households in a random sample of 90 clusters in the coastal regions; the clusters were randomly allocated to intervention or control and re-surveyed in 2012...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699563/the-women-made-it-work-fuzzy-transitive-closure-of-the-results-chain-in-a-dengue-prevention-trial-in-mexico
#12
Neil Andersson, Mario Beauchamp, Elizabeth Nava-Aguilera, Sergio Paredes-Solís, Mateja Šajna
BACKGROUND: A modified theory of planned behaviour (acronym CASCADA) proposes that Conscious knowledge precedes a change in Attitude, which in turn precedes positive deviations from negative Subjective norms, intention to Change, perception of Agency to change, Discussion of possible action, and Action itself. We used this as a results chain to investigate gender-specific behaviour dynamics in chemical-free dengue prevention. METHODS: Secondary analysis of the Mexican arm of a cluster randomised controlled trial used household survey data on intermediate outcomes of dengue prevention behaviour...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699562/which-green-way-description-of-the-intervention-for-mobilising-against-aedes-aegypti-under-difficult-security-conditions-in-southern-mexico
#13
REVIEW
Arcadio Morales-Perez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Sergio Paredes-Solís, Alejandro Balanzar-Martínez, Felipe René Serrano-de Los Santos, Claudia Erika Ríos-Rivera, Jaime García-Leyva, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: Community mobilisation for prevention requires engagement with and buy in from those communities. In the Mexico state of Guerrero, unprecedented social violence related to the narcotics trade has eroded most community structures. A recent randomised controlled trial in 90 coastal communities achieved sufficient mobilisation to reduce conventional vector density indicators, self-reported dengue illness and serologically proved dengue virus infection. METHODS: The Camino Verde intervention was a participatory research protocol promoting local discussion of baseline evidence and co-design of vector control solutions...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699561/mobilising-communities-for-aedes-aegypti-control-the-sepa-approach
#14
REVIEW
Robert J Ledogar, Jorge Arosteguí, Carlos Hernández-Alvarez, Arcadio Morales-Perez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Harold Suazo-Laguna, Alejandro Belli, Jorge Laucirica, Josefina Coloma, Eva Harris, Neil Andersson
Camino Verde (the Green Way) is an evidence-based community mobilisation tool for prevention of dengue and other mosquito-borne viral diseases. Its effectiveness was demonstrated in a cluster-randomised controlled trial conducted in 2010-2013 in Nicaragua and Mexico. The common approach that brought functional consistency to the Camino Verde intervention in both Mexico and Nicaragua is Socialisation of Evidence for Participatory Action (SEPA). In this article, we explain the SEPA concept and its theoretical origins, giving examples of its previous application in different countries and contexts...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699560/dengue-occurrence-relations-and-serology-cross-sectional-analysis-of-results-from-the-guerrero-state-mexico-baseline-for-a-cluster-randomised-controlled-trial-of-community-mobilisation-for-dengue-prevention
#15
Elizabeth Nava-Aguilera, Arcadio Morales-Pérez, Alejandro Balanzar-Martínez, Ofelia Rodríguez-Ramírez, Abel Jiménez-Alejo, Miguel Flores-Moreno, David Gasga-Salinas, José Legorreta-Soberanis, Sergio Paredes-Solís, Pedro Antonio Morales-Nava, María de Lourdes Soto-Ríos, Robert J Ledogar, Joséfina Coloma, Eva Harris, Neil Andersson
BACKGROUND: The Mexican arm of the Camino Verde trial of community mobilisation for dengue prevention covered three coastal regions of Guerrero state: Acapulco, Costa Grande and Costa Chica. A baseline cross-sectional survey provided data for community mobilisation and for adapting the intervention design to concrete conditions in the intervention areas. METHODS: Trained field teams constructed community profiles in randomly selected clusters, based on observation and key informant interviews...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699559/aedes-aegypti-breeding-ecology-in-guerrero-cross-sectional-study-of-mosquito-breeding-sites-from-the-baseline-for-the-camino-verde-trial-in-mexico
#16
Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Alejandro Balanzar-Martínez, Antonio Juan Cortés-Guzmán, David Gasga-Salinas, Irma Esther Rodríguez-Ramos, Alba Meneses-Rentería, Sergio Paredes-Solís, José Legorreta-Soberanis, Felipe Gil Armendariz-Valle, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: Understanding the breeding patterns of Aedes aegypti in households and the factors associated with infestation are important for implementing vector control. The baseline survey of a cluster randomised controlled trial of community mobilisation for dengue prevention in Mexico and Nicaragua collected information about the containers that are the main breeding sites, identified possible actions to reduce breeding, and examined factors associated with household infestation. This paper describes findings from the Mexican arm of the baseline survey...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699558/beyond-efficacy-in-water-containers-temephos-and-household-entomological-indices-in-six-studies-between-2005-and-2013-in-managua-nicaragua
#17
Jorge Arosteguí, Josefina Coloma, Carlos Hernández-Alvarez, Harold Suazo-Laguna, Angel Balmaseda, Eva Harris, Neil Andersson, Robert J Ledogar
BACKGROUND: A cluster-randomized controlled trial of community mobilisation for dengue prevention in Mexico and Nicaragua reported, as a secondary finding, a higher risk of dengue virus infection in households where inspectors found temephos in water containers. Data from control sites in the preceding pilot study and the Nicaragua trial arm provided six time points (2005, 2006, 2007 and 2011, 2012, 2013) to examine potentially protective effects of temephos on entomological indices under every day conditions of the national vector control programme...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699557/-where-we-put-little-fish-in-the-water-there-are-no-mosquitoes-a-cross-sectional-study-on-biological-control-of-the-aedes-aegypti-vector-in-90-coastal-region-communities-of-guerrero-mexico
#18
Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Antonio Juan Cortés-Guzmán, Alejandro Balanzar-Martínez, Eva Harris, Josefina Coloma, Víctor M Alvarado-Castro, Mónica Violeta Bonilla-Leon, Liliana Morales-Nava, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: In the Mexican state of Guerrero, some households place fish in water storage containers to prevent the development of mosquito larvae. Studies have shown that larvivorous fish reduce larva count in household water containers, but there is a lack of evidence about whether the use of fish is associated with a reduction in dengue virus infection. We used data from the follow up survey of the Camino Verde cluster randomised controlled trial of community mobilisation to reduce dengue risk to study this association...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699556/community-led-trials-intervention-co-design-in-a-cluster-randomised-controlled-trial
#19
Neil Andersson
In conventional randomised controlled trials (RCTs), researchers design the interventions. In the Camino Verde trial, each intervention community designed its own programmes to prevent dengue. Instead of fixed actions or menus of activities to choose from, the trial randomised clusters to a participatory research protocol that began with sharing and discussing evidence from a local survey, going on to local authorship of the action plan for vector control.Adding equitable stakeholder engagement to RCT infrastructure anchors the research culturally, making it more meaningful to stakeholders...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699555/pupal-productivity-in-rainy-and-dry-seasons-findings-from-the-impact-survey-of-a-randomised-controlled-trial-of-dengue-prevention-in-guerrero-mexico
#20
Abel Jiménez-Alejo, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Miguel Flores-Moreno, Sinahí Apreza-Aguilar, Wilhelm Carranza-Alcaraz, Antonio Juan Cortés-Guzmán, Ildefonso Fernández-Salas, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: The follow-up survey of a cluster-randomised controlled trial of evidence-based community mobilisation for dengue control in Nicaragua and Mexico included entomological information from the 2012 rainy and dry seasons. We used data from the Mexican arm of the trial to assess the impact of the community action on pupal production of the dengue vector Aedes aegypti in both rainy and dry seasons. METHODS: Trained field workers inspected household water containers in 90 clusters and collected any pupae or larvae present for entomological examination...
May 30, 2017: BMC Public Health
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