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https://www.readbyqxmd.com/read/29781412/imported-cases-and-minimum-temperature-drive-dengue-transmission-in-guangzhou-china-evidence-from-arimax-model
#1
Q L Jing, Q Cheng, J M Marshall, W B Hu, Z C Yang, J H Lu
Dengue is the fastest spreading mosquito-transmitted disease in the world. In China, Guangzhou City is believed to be the most important epicenter of dengue outbreaks although the transmission patterns are still poorly understood. We developed an autoregressive integrated moving average model incorporating external regressors to examine the association between the monthly number of locally acquired dengue infections and imported cases, mosquito densities, temperature and precipitation in Guangzhou. In multivariate analysis, imported cases and minimum temperature (both at lag 0) were both associated with the number of locally acquired infections (P < 0...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#2
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29777177/controlling-vector-borne-diseases-by-releasing-modified-mosquitoes
#3
REVIEW
Heather A Flores, Scott L O'Neill
Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are becoming major global health emergencies while old threats, such as yellow fever, are re-emerging. Traditional control methods, which have focused on reducing mosquito populations through the application of insecticides or preventing breeding through removal of larval habitat, are largely ineffective, as evidenced by the increasing global disease burden. Here, we review novel mosquito population reduction and population modification approaches with a focus on control methods based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes and strategies to genetically modify the vector, that are currently under development and have the potential to contribute to a reversal of the current alarming disease trends...
May 18, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#4
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29759076/threats-of-zika-virus-transmission-for-asia-and-its-hindu-kush-himalayan-region
#5
Meghnath Dhimal, Sushma Dahal, Mandira Lamichhane Dhimal, Shiva Raj Mishra, Khem B Karki, Krishna Kumar Aryal, Ubydul Haque, Md Iqbal Kabir, Pradeep Guin, Azeem Mehmood Butt, Harapan Harapan, Qi-Yong Liu, Cordia Chu, Doreen Montag, David Alexander Groneberg, Basu Dev Pandey, Ulrich Kuch, Ruth Müller
Asia and its Hindu Kush Himalayan (HKH) region is particularly vulnerable to environmental change, especially climate and land use changes further influenced by rapid population growth, high level of poverty and unsustainable development. Asia has been a hotspot of dengue fever and chikungunya mainly due to its dense human population, unplanned urbanization and poverty. In an urban cycle, dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by Aedes aegypti and Ae. albopictus mosquitoes which are also competent vectors of Zika virus (ZIKV)...
May 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29753658/feasibility-and-biological-rationale-of-repurposing-sunitinib-and-erlotinib-for-dengue-treatment
#6
Szuyuan Pu, Fei Xiao, Stanford Schor, Elena Bekerman, Fabio Zanini, Rina Barouch-Bentov, Claude M Nagamine, Shirit Einav
There is an urgent need for strategies to combat dengue virus (DENV) infection; a major global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular trafficking of multiple viruses and that sunitinib and erlotinib, approved anticancer drugs with potent activity against these kinases, protect DENV-infected mice from mortality. Nevertheless, further characterization of the therapeutic potential and underlying mechanism of this approach is required prior to clinical evaluation. Here, we demonstrate that sunitinib/erlotinib combination achieves sustained suppression of systemic infection at approved dose in DENV-infected IFN-α/β and IFN-γ receptor-deficient mice...
May 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29751758/factors-associated-with-dengue-prevention-behaviour-in-lowokwaru-malang-indonesia-a-cross-sectional-study
#7
Alidha Nur Rakhmani, Yanin Limpanont, Jaranit Kaewkungwal, Kamolnetr Okanurak
BACKGROUND: Dengue prevention is important for controlling the spread of dengue infection. Transmission of dengue can be prevented by controlling mosquito breeding sites. Indonesia has dengue a prevention program to minimize mosquito breeding sites known as 3 M Plus. This study aimed to investigate factors associated with dengue prevention behaviour among respondents in the Lowokwaru subdistrict, an urban area in Malang, Indonesia. METHODS: This cross-sectional study used a semi-structured questionnaire that was conducted by face-to-face interview...
May 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29743368/stat2-dependent-immune-responses-ensure-host-survival-despite-the-presence-of-a-potent-viral-antagonist
#8
Vu Thuy Khanh Le-Trilling, Kerstin Wohlgemuth, Meike U Rückborn, Andreja Jagnjic, Fabienne Maaßen, Lejla Timmer, Benjamin Katschinski, Mirko Trilling
Pathogen encounter induces interferons which signal via Janus kinases and STAT transcription factors to establish an antiviral state. However, host and pathogens are situated in a continuous arms race which shapes host evolution towards optimized immune responses and the pathogens towards enhanced immune evasive properties.Mouse cytomegalovirus (MCMV) counteracts interferon responses by pM27-mediated degradation of STAT2 which directly affects the signaling of type I as well as type III interferons. Using MCMV mutants lacking M27 and mice lacking STAT2, we studied the opposing relationship between antiviral activities and viral antagonism in a natural host-pathogen pair in vitro and in vivo In contrast to wt-MCMV, ΔM27-MCMV was efficiently cleared from all organs within a few days in BALB/c, C57BL/6, and 129 mice, highlighting the general importance of STAT2 antagonism for MCMV replication...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29743365/dengue-virus-induces-increased-activity-of-the-complement-alternative-pathway-in-infected-cells
#9
Sheila Cabezas, Gustavo Bracho, Amanda L Aloia, Penelope J Adamson, Claudine S Bonder, Justine R Smith, David L Gordon, Jillian M Carr
Severe dengue virus (DENV) infection is associated with overactivity of the complement alternative pathway (AP) in patient studies. Here, the molecular changes in components of the AP during DENV infection in vitro are investigated. mRNA for factor H (FH) a major negative regulator of the AP, is significantly increased in DENV-infected endothelial cells (EC) and macrophages but in contrast production of extracellular FH protein is not. This discord is not seen for the AP activator, factor B (FB), with DENV induction of both FB mRNA and protein, nor with Toll-like receptor 3 or 4 stimulation of EC and macrophages, which induces both FH and FB mRNA and protein...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29740424/modulation-of-dengue-zika-virus-pathogenicity-by-antibody-dependent-enhancement-and-strategies-to-protect-against-enhancement-in-zika-virus-infection
#10
REVIEW
Rekha Khandia, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Yashpal Singh Malik, Raj Kumar Singh, Wanpen Chaicumpa
Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito-borne flaviviruses such as Dengue virus (DENV) and Zika virus (ZIKV). In vitro experimental evidences have indicated the preventive, as well as a pathogenicity-enhancing role, of preexisting DENV antibodies in ZIKV infections. ADE has been confirmed in DENV but not ZIKV infections. Principally, the Fc region of the anti-DENV antibody binds with the fragment crystallizable gamma receptor (FcγR), and subsequent C1q interactions and immune effector functions are responsible for the ADE...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29735824/molecular-characterisation-and-phylogenetic-analysis-of-dengue-outbreak-in-pasighat-arunachal-pradesh-northeast-india
#11
Biswajyoti Borkakoty, Mandakini Das, Kishore Sarma, Aniruddha Jakharia, Palash Kumar Das, Chandrakanta Bhattacharya, Basumoti Apum, Dipankar Biswas
Background and Objectives: Dengue is one of the most prevalent arboviral diseases in the world with 390 million dengue infections per year. In this study, we report the molecular characterisation of dengue outbreak in Pasighat, Arunachal Pradesh, Northeast India during 2015. Subjects and Methods: : A total of 613 dengue-suspected cases were screened for dengue virus by dengue NS1 Ag and anti-dengue IgM antibody depending on the duration of sample collection and onset of symptom...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29733947/sphingolipid-signaling-modulates-trans-endothelial-cell-permeability-in-dengue-virus-infected-hmec-1-cells
#12
M G Anupriya, Sneha Singh, Neha Vijay Hulyalkar, Easwaran Sreekumar
Dengue has emerged as a major mosquito-borne disease in the tropics and subtropics. In severe dengue, enhanced microvascular endothelial permeability leads to plasma leakage. Direct dengue virus (DENV) infection in human microvascular endothelial cells (HMEC-1) can enhance trans-endothelial leakage. Using a microarray-based analysis, we identified modulation of key endothelial cell signaling pathways in DENV-infected HMEC-1 cells. One among them was the sphingolipid pathway that regulates vascular barrier function...
May 4, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29713901/efficacy-of-larvicides-for-the-control-of-dengue-zika-and-chikungunya-vectors-in-an-urban-cemetery-in-southern-mexico
#13
Carlos F Marina, J Guillermo Bond, José Muñoz, Javier Valle, Humberto Quiroz-Martínez, Jorge A Torres-Monzón, Trevor Williams
Many countries in Latin America have recently experienced outbreaks of Zika and chikungunya fever, in additional to the usual burden imposed by dengue, all of which are transmitted by Aedes aegypti in this region. To identify potential larvicides, we determined the toxicity of eight modern insecticides to A. aegypti larvae from a colony that originated from field-collected insects in southern Mexico. The most toxic compounds were pyriproxyfen (which prevented adult emergence) and λ-cyhalothrin, followed by spinetoram, imidacloprid, thiamethoxam, and acetamiprid, with chlorantraniliprole and spiromesifen the least toxic products...
April 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29709630/space-time-clusters-and-co-occurrence-of-chikungunya-and-dengue-fever-in-colombia-from-2015-to-2016
#14
M R Desjardins, A Whiteman, I Casas, E Delmelle
Vector-borne diseases (VBDs) infect over one billion people and are responsible for over one million deaths each year, globally. Chikungunya (CHIK) and Dengue Fever (DENF) are emerging VBDs due to overpopulation, increases in urbanization, climate change, and other factors. Colombia has recently experienced severe outbreaks of CHIK AND DENF. Both viruses are transmitted by the Aedes mosquitoes and are preventable with a variety of surveillance and vector control measures (e.g. insecticides, reduction of open containers, etc...
April 27, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29706319/zika-virus-epidemiological-study-and-its-association-with-public-health-risk
#15
REVIEW
Rashed Noor, Tasnia Ahmed
Propagation of Zika virus has become an alarming global public health issue. The infection is spreading rapidly to different countries by several methods, especially by the transmission through traveling. Bangladesh is also at a risk to be affected with such newly viral infections. Though the virus initially appears to cause mild problems, the long term effects are more devastating to the next generation as seen in case of the delivery of the microcephalic babies. Current review discussed the epidemiologic era of the virus; i...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29702687/macrophage-migration-inhibitory-factor-is-critical-for-dengue-ns1-induced-endothelial-glycocalyx-degradation-and-hyperpermeability
#16
Hong-Ru Chen, Chiao-Hsuan Chao, Ching-Chuan Liu, Tzong-Shiann Ho, Huey-Pin Tsai, Guey-Chuen Perng, Yee-Shin Lin, Jen-Ren Wang, Trai-Ming Yeh
Vascular leakage is one of the salient characteristics of severe dengue. Nonstructural protein 1 (NS1) of dengue virus (DENV) can stimulate endothelial cells to secrete endothelial hyperpermeability factor, macrophage migration inhibitory factor (MIF), and the glycocalyx degradation factor heparanase 1 (HPA-1). However, it is unclear whether MIF is directly involved in NS1-induced glycocalyx degradation. In this study, we observed that among NS1, MIF and glycocalyx degradation-related molecules, the HPA-1, metalloproteinase 9 (MMP-9) and syndecan 1 (CD138) serum levels were all increased in dengue patients, and only NS1 and MIF showed a positive correlation with the CD138 level in severe patients...
April 27, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#17
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29694372/data-quality-and-timeliness-of-outbreak-reporting-system-among-countries-in-greater-mekong-subregion-challenges-for-international-data-sharing
#18
Saranath Lawpoolsri, Jaranit Kaewkungwal, Amnat Khamsiriwatchara, Ly Sovann, Bun Sreng, Bounlay Phommasack, Viengsavanh Kitthiphong, Soe Lwin Nyein, Nyan Win Myint, Nguyen Dang Vung, Pham Hung, Mark S Smolinski, Adam W Crawley, Moe Ko Oo
Cross-border disease transmission is a key challenge for prevention and control of outbreaks. Variation in surveillance structure and national guidelines used in different countries can affect their data quality and the timeliness of outbreak reports. This study aimed to evaluate timeliness and data quality of national outbreak reporting for four countries in the Mekong Basin Disease Surveillance network (MBDS). Data on disease outbreaks occurring from 2010 to 2015 were obtained from the national disease surveillance reports of Cambodia, Lao PDR, Myanmar, and Vietnam...
April 25, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29694346/aminopeptidase-secreted-by-chromobacterium-sp-panama-inhibits-dengue-virus-infection-by-degrading-the-e-protein
#19
Raúl G Saraiva, Jingru Fang, Seokyoung Kang, Yesseinia I Angleró-Rodríguez, Yuemei Dong, George Dimopoulos
Dengue virus (DENV) is the most prevalent and burdensome arbovirus transmitted by Aedes mosquitoes, against which there is only a limited licensed vaccine and no approved drug treatment. A Chromobacterium species, C. sp. Panama, isolated from the midgut of A. aegypti is able to inhibit DENV replication within the mosquito and in vitro. Here we show that C. sp. Panama mediates its anti-DENV activity through secreted factors that are proteinous in nature. The inhibitory effect occurs prior to virus attachment to cells, and is attributed to a factor that destabilizes the virion by promoting the degradation of the viral envelope protein...
April 25, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29691914/definitions-for-warning-signs-and-signs-of-severe-dengue-according-to-the-who-2009-classification-systematic-review-of-literature
#20
REVIEW
Mostafa Ebraheem Morra, Ahmed M A Altibi, Somia Iqtadar, Le Huu Nhat Minh, Sameh Samir Elawady, Asma Hallab, Abdelrahman Elshafay, Omer Abedlbagi Omer, Ahmed Iraqi, Purushottam Adhikari, Jonair Hussein Labib, Khaled Mosaad Elhusseiny, Ahmed Elgebaly, Sophie Yacoub, Le Thi Minh Huong, Kenji Hirayama, Nguyen Tien Huy
Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, "warning signs," "severe dengue," and "classification." A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification...
April 24, 2018: Reviews in Medical Virology
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