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https://www.readbyqxmd.com/read/28427352/point-of-sampling-detection-of-zika-virus-within-a-multiplexed-kit-capable-of-detecting-dengue-and-chikungunya
#1
Ozlem Yaren, Barry W Alto, Priyanka V Gangodkar, Shatakshi R Ranade, Kunal N Patil, Kevin M Bradley, Zunyi Yang, Nikhil Phadke, Steven A Benner
BACKGROUND: Zika, dengue, and chikungunya are three mosquito-borne viruses having overlapping transmission vectors. They cause diseases having similar symptoms in human patients, but requiring different immediate management steps. Therefore, rapid (< one hour) discrimination of these three viruses in patient samples and trapped mosquitoes is needed. The need for speed precludes any assay that requires complex up-front sample preparation, such as extraction of nucleic acids from the sample...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28426114/infectious-diseases-and-migrant-worker-health-in-singapore-a-receiving-country-s-perspective
#2
Sapna P Sadarangani, Poh Lian Lim, Shawn Vasoo
Background.: Approximately 1.4 million migrant workers reside in Singapore, presenting unique infectious disease challenges to both migrants and Singapore. Methods.: A Pubmed, MEDLINE (Ovid), EBSCO Host (Global Health) and Google Scholar search was performed for both peer, non-peer reviewed articles and reports relevant to migrant health in Singapore, published between 1 January 1989 and 1 September 2016. Additional studies were identified from citations within searched articles...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28425959/the-cost-of-arbovirus-disease-prevention-in-europe-area-wide-integrated-control-of-tiger-mosquito-aedes-albopictus-in-emilia-romagna-northern-italy
#3
Massimo Canali, Stefano Rivas-Morales, Philippe Beutels, Claudio Venturelli
Aedes albopictus (tiger mosquito) has become the most invasive mosquito species worldwide, in addition to being a well-known vector of diseases, with a proven capacity for the transmission of chikungunya and dengue viruses in Europe as well as the Zika virus in Africa and in laboratory settings. This research quantifies the cost that needs to be provided by public-health systems for area-wide prevention of arboviruses in Europe. This cost has been calculated by evaluating the expenditure of the plan for Aedes albopictus control set up in the Emilia-Romagna region (Northern Italy) after a chikungunya outbreak occurred in 2007...
April 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28422757/cross-reactive-dengue-human-monoclonal-antibody-prevents-severe-pathologies-and-death-from-zika-virus-infections
#4
Yiu-Wing Kam, Cheryl Yi-Pin Lee, Teck-Hui Teo, Shanshan W Howland, Siti Naqiah Amrun, Fok-Moon Lum, Peter See, Nicholas Qing-Rong Kng, Roland G Huber, Mei-Hui Xu, Heng-Liang Tan, Andre Choo, Sebastian Maurer-Stroh, Florent Ginhoux, Katja Fink, Cheng-I Wang, Lisa F P Ng, Laurent Rénia
Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. Given the high level of homology between ZIKV and the related flavivirus dengue virus (DENV), we investigated the level of cross-reactivity with ZIKV using a panel of DENV human mAbs. A majority of the mAbs showed binding to ZIKV virions, with several exhibiting neutralizing capacities against ZIKV in vitro. Three of the best ZIKV-neutralizing mAbs were found to recognize diverse epitopes on the envelope (E) glycoprotein: the highly conserved fusion-loop peptide, a conformation-specific epitope on the E monomer, and a quaternary epitope on the virion surface...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28422053/erratum-wong-l-p-et-al-the-self-regulation-model-of-illness-comparison-between-zika-and-dengue-and-its-application-to-predict-mosquito-prevention-behaviours-in-malaysia-a-dengue-endemic-country-int-j-environ-res-public-health-2016-13-1210
#5
https://www.readbyqxmd.com/read/28414218/exploiting-the-anti-aggregation-of-gold-nanostars-for-rapid-detection-of-hand-foot-and-mouth-disease-causing-enterovirus-71-using-surface-enhanced-raman-spectroscopy
#6
Miguel Reyes, Marek Piotrowski, Swee Kim Ang, Jingqi Chan, Shuai He, Justin Jang Hann Chu, James Chen Yong Kah
Enterovirus 71 (EV71) is a major public health threat that requires rapid point-of-care detection. Here, we developed a surface-enhanced Raman spectroscopy (SERS)-based scheme that utilized protein-induced aggregation of colloidal gold nanostars (AuNS) to rapidly detect EV71 without the need for fabricating a solid substrate, Raman labels or complicated sample handling. We used AuNS (hydrodynamic diameter, DH of 105.12 ± 1.13 nm) conjugated to recombinant scavenger receptor class B, member 2 (SCARB2) protein with known affinity to EV71...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28405192/induction-of-osteopontin-by-dengue-virus-3-infection-in-thp-1-cells-inhibition-of-the-synthesis-by-brefelamide-and-its-derivative
#7
Dyshelly N Pascapurnama, Hannah K M Labayo, Isolde Dapat, Divya D Nagarajegowda, Jingge Zhao, Jing Zhang, Osamu Yamada, Haruhisa Kikuchi, Shinichi Egawa, Yoshiteru Oshima, Haorile Chagan-Yasutan, Toshio Hattori
Osteopontin (OPN) is a multifunctional matricellular protein produced by a broad range of cells including osteoclasts, macrophages, T cells, endothelial cells, and vascular smooth muscle cells. OPN modulates various physiological and pathological events such as inflammation, wound healing, and bone formation and remodeling. Dengue virus (DENV) infection causes an increase in plasma OPN levels, which is correlated with the severity of symptoms and coagulation abnormalities. DENV infection also induces OPN gene expression in human macrophages...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28402436/repellency-of-29-synthetic-and-natural-commercial-topical-insect-repellents-against-aedes-aegypti-diptera-culicidae-in-central-mexico
#8
Pablo A Kuri-Morales, Fabián Correa-Morales, Cassandra González-Acosta, Gustavo Sánchez-Tejeda, Miguel Moreno-Garcia, Eduardo Dávalos-Becerril, Marissa F Juárez-Franco, José Ismael Benitez-Alva, Jesús F González-Roldán
In Mexico, the use of repellents to prevent insects from landing and biting is a common practice. However, variation in the efficiency of natural and synthetic repellents has been observed. In this study, we evaluated the repellency and protection time of 16 synthetic and 13 natural-based commercial products against Aedes aegypti (L.) from an endemic dengue area (Jojutla, Morelos) in Central Mexico. The "arm exposure" cage test was used to assess the efficacy of the repellents. Tests were conducted by three adult volunteers...
April 10, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28389893/toxicity-of-herbal-extracts-used-in-ethno-veterinary-medicine-and-green-encapsulated-zno-nanoparticles-against-aedes-aegypti-and-microbial-pathogens
#9
Balan Banumathi, Baskaralingam Vaseeharan, Ramachandran Ishwarya, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
Dengue and chikungunya are arboviral diseases mainly vectored by the mosquito Aedes aegypti. Presently, there is no treatment for these viral diseases and their prevention is still based on vector control measures. Nanopesticides fabricated using herbal extracts as reducing and capping agents currently represent an excellent platform for pest control. In this scenario, the present study assessed the acute toxicity of seven plants employed in ethno-veterinary medicine of southern India, as well as the green synthesis of zinc oxide nanoparticles, on third-instar larvae of A...
April 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28389269/estimation-of-reproduction-number-and-non-stationary-spectral-analysis-of-dengue-epidemic
#10
Murali Krishna Enduri, Shivakumar Jolad
In this work we analyze the post monsoon Dengue outbreaks by analyzing the transient and long term dynamics of Dengue incidences and its environmental correlates in Ahmedabad city in western India from 2005 to 2012. We calculate the reproduction number Rp using the growth rate of post monsoon Dengue outbreaks and biological parameters like host and vector incubation periods and vector mortality rate, and its uncertainties are estimated through Monte-Carlo simulations by sampling parameters from their respective probability distributions...
April 5, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28388922/viral-and-serological-kinetics-in-zika-virus-infected-patients-in-south-korea
#11
Young Eui Jeong, Go-Woon Cha, Jung Eun Cho, Eun Ju Lee, Youngmee Jee, Won-Ja Lee
Zika virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections. The Korea Centers for Disease Control and Prevention initiated laboratory testing using a real-time reverse transcription-polymerase chain reaction in January 2016. More than 1,000 suspected cases of infection were tested and nine were confirmed as imported cases of Zika virus infection from January to July 2016. The travel destinations of the infected individuals were Brazil, Philippines, Viet Nam, Guatemala, Puerto Rico, and the Dominican Republic...
April 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28388694/determination-of-clusters-and-factors-associated-with-dengue-dispersion-during-the-first-epidemic-related-to-dengue-virus-serotype-4-in-vit%C3%A3-ria-brazil
#12
Creuza Rachel Vicente, Karl-Heinz Herbinger, Crispim Cerutti Junior, Camila Malta Romano, Aline de Souza Areias Cabidelle, Günter Fröschl
Dengue occurrence is partially influenced by the immune status of the population. Consequently, the introduction of a new Dengue virus serotype can trigger explosive epidemics in susceptible populations. The determination of clusters in this scenario can help to identify hotspots and understand the disease dispersion regardless of the influence of the population herd immunity. The present study evaluated the pattern and factors associated with dengue dispersion during the first epidemic related to Dengue virus serotype 4 in Vitória, Espírito Santo state, Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28386524/surveillance-of-arthropod-borne-viruses-and-their-vectors-in-the-mediterranean-and-black-sea-regions-within-the-medilabsecure-network
#13
REVIEW
Anna-Bella Failloux, Ali Bouattour, Chafika Faraj, Filiz Gunay, Nabil Haddad, Zoubir Harrat, Elizabeta Jancheska, Khalil Kanani, Mohamed Amin Kenawy, Majlinda Kota, Igor Pajovic, Lusine Paronyan, Dusan Petric, Mhammed Sarih, Samir Sawalha, Taher Shaibi, Kurtesh Sherifi, Tatiana Sulesco, Enkelejda Velo, Lobna Gaayeb, Kathleen Victoir, Vincent Robert
PURPOSE OF REVIEW: Arboviruses, viruses transmitted by arthropods such as mosquitoes, ticks, sandflies, and fleas are a significant threat to public health because of their epidemic and zoonotic potential. The geographical distribution of mosquito-borne diseases such as West Nile (WN), Rift Valley fever (RVF), Dengue, Chikungunya, and Zika has expanded over the last decades. Countries of the Mediterranean and Black Sea regions are not spared. Outbreaks of WN are repeatedly reported in the Mediterranean basin...
2017: Current Tropical Medicine Reports
https://www.readbyqxmd.com/read/28385591/optimal-control-problems-of-mosquito-borne-disease-subject-to-changes-in-feeding-behavior-of-aedes-mosquitoes
#14
M A Masud, Byul Nim Kim, Yongkuk Kim
Dengue viruses (DENV) are transmitted to humans by the bite of Aedes mosquitoes. It is known that dengue virus infection in Aedes aegypti female mosquitoes makes a change in the feeding behavior of the infected mosquitoes. In this study, using the forces of infection, we incorporated the effect of changes in the feeding behavior of mosquitoes into the standard vector-borne SIR-SI model. It has been proved that both a single-strain model and a two-strain model exhibit forward bifurcations. Moreover, optimal implementations of control with specific prevention measures for dengue transmission are analyzed...
April 3, 2017: Bio Systems
https://www.readbyqxmd.com/read/28380060/cost-effectiveness-of-dengue-vaccination-in-yucat%C3%A3-n-mexico-using-a-dynamic-dengue-transmission-model
#15
Eunha Shim
BACKGROUND: The incidence of dengue fever (DF) is steadily increasing in Mexico, burdening health systems with consequent morbidities and mortalities. On December 9th, 2015, Mexico became the first country for which the dengue vaccine was approved for use. In anticipation of a vaccine rollout, analysis of the cost-effectiveness of the dengue vaccination program that quantifies the dynamics of disease transmission is essential. METHODS: We developed a dynamic transmission model of dengue in Yucatán, Mexico and its proposed vaccination program to incorporate herd immunity into our analysis of cost-effectiveness analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28375541/unravelling-the-paediatric-and-perinatal-zika-virus-epidemic-through-population-based-research
#16
Cdc Christie, C Giaquinto
Zika virus epidemic now involves 72 countries, worldwide. Transmission is multimodal through mosquito bites and blood and body fluids. Zika virus causes Guillain Barre Syndrome syndrome and pregnancy complications including perinatal microcephaly. Diagnosis is complicated by subclinical infection in 80%, co-circulation with dengue and chikungunya fevers with similar presentations and cross-reactivity in serological tests. There is no cure, or preventive vaccine. Large population-based studies will help to elucidate ZIKV epidemiology, vertical transmission, risks to the fetus of maternal ZIKV infection and natural history of congenital and non-congenital ZIKV infection as provided by the activities in the "ZIKAction" research consortium in Latin America, Europe and the Caribbean, which was recently funded by the European Commission...
September 19, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/28369149/socioeconomic-and-environmental-determinants-of-dengue-transmission-in-an-urban-setting-an-ecological-study-in-noum%C3%A3-a-new-caledonia
#17
Raphaël M Zellweger, Jorge Cano, Morgan Mangeas, François Taglioni, Alizé Mercier, Marc Despinoy, Christophe E Menkès, Myrielle Dupont-Rouzeyrol, Birgit Nikolay, Magali Teurlai
BACKGROUND: Dengue is a mosquito-borne virus that causes extensive morbidity and economic loss in many tropical and subtropical regions of the world. Often present in cities, dengue virus is rapidly spreading due to urbanization, climate change and increased human movements. Dengue cases are often heterogeneously distributed throughout cities, suggesting that small-scale determinants influence dengue urban transmission. A better understanding of these determinants is crucial to efficiently target prevention measures such as vector control and education...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28360441/neutralizing-antibody-response-and-efficacy-of-novel-recombinant-tetravalent-dengue-dna-vaccine-comprising-envelope-domain-iii-in-mice
#18
Ajit Kulkarni, Rushil Bhat, Mansi Malik, Suvarna Sane, Sweta Kothari, Shashikant Vaidya, Abhay Chowdhary, Ranjana A Deshmukh
BACKGROUND: Dengue is a global arboviral threat to humans; causing 390 million infections per year. The availability of safe and effective tetravalent dengue vaccine is a global requirement to prevent epidemics, morbidity, and mortality associated with it. METHODS: Five experimental groups (6 mice per group) each of 5-week-old BALB/c mice were immunized with vaccine and placebo (empty plasmid) (100 µg, i.m.) on days 0, 14 and 28. Among these, four groups (one group per serotype) of each were subsequently challenged 3 weeks after the last boost with dengue virus (DENV) serotypes 1-4 (100 LD50, 20 µl intracerebrally) to determine vaccine efficacy...
March 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28358796/yellow-fever-outbreak-kongo-central-province-democratic-republic-of-the-congo-august-2016
#19
John O Otshudiema, Nestor G Ndakala, Elande-Taty K Mawanda, Gaston P Tshapenda, Jacques M Kimfuta, Loupy-Régence N Nsibu, Abdou S Gueye, Jacob Dee, Rossanne M Philen, Coralie Giese, Christopher S Murrill, Ray R Arthur, Benoit I Kebela
On April 23, 2016, the Democratic Republic of the Congo's (DRC's) Ministry of Health declared a yellow fever outbreak. As of May 24, 2016, approximately 90% of suspected yellow fever cases (n = 459) and deaths (45) were reported in a single province, Kongo Central Province, that borders Angola, where a large yellow fever outbreak had begun in December 2015. Two yellow fever mass vaccination campaigns were conducted in Kongo Central Province during May 25-June 7, 2016 and August 17-28, 2016. In June 2016, the DRC Ministry of Health requested assistance from CDC to control the outbreak...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28357366/inhibition-of-zika-virus-by-wolbachia-in-aedes-aegypti
#20
COMMENT
Eric Pearce Caragata, Heverton Leandro Carneiro Dutra, Luciano Andrade Moreira
Through association with cases of microcephaly in 2015, Zika virus (ZIKV) has transitioned from a relatively unknown mosquito-transmitted pathogen to a global health emergency, emphasizing the need to improve existing mosquito control programs to prevent future disease outbreaks. The response to Zika must involve a paradigm shift from traditional to novel methods of mosquito control, and according to the World Health Organization should incorporate the release of mosquitoes infected with the bacterial endosymbiont Wolbachiapipientis...
June 27, 2016: Microbial Cell
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