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https://www.readbyqxmd.com/read/28074128/epidemic-outbreak-of-chikungunya-in-two-neighboring-towns-in-the-colombian-caribbean-a-survival-analysis
#1
Misael Oviedo-Pastrana, Nelson Méndez, Salim Mattar, Germán Arrieta, Luty Gomezcaceres
BACKGROUND: The first autochthonous Chikungunya virus transmission in Colombia was reported in September 2014. Three months later, every town in the Caribbean region was affected, including the bordering towns of Ovejas and Corozal, in the department of Sucre. The objective of the study was to analyze and compare the temporal dynamics of the outbreak of Chikungunya in two towns of the department of Sucre. METHODS: Households with suspicious cases with clinical symptomatology for Chikungunya were enrolled...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28054419/identification-and-initial-characterization-of-matrix-metalloproteinases-in-the-yellow-fever-mosquito-aedes-aegypti
#2
A M Kantor, S Dong, N L Held, E Ishimwe, A L Passarelli, R J Clem, A W E Franz
Aedes aegypti is a major vector for arboviruses such as dengue, chikungunya and Zika viruses. During acquisition of a viremic bloodmeal, an arbovirus infects mosquito midgut cells before disseminating to secondary tissues, including the salivary glands. Once virus is released into the salivary ducts it can be transmitted to another vertebrate host. The midgut is surrounded by a basal lamina (BL) in the extracellular matrix, consisting of a proteinaceous mesh composed of collagen IV and laminin. BL pore size exclusion limit prevents virions from passing through...
February 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28052239/honeysuckle-aqueous-extract-and-induced-let-7a-suppress-dengue-virus-type-2-replication-and-pathogenesis
#3
Ying-Ray Lee, Siao-Fen Yeh, Xiao-Ming Ruan, Hao Zhang, Sheng-Da Hsu, Hsien-Da Huang, Chang-Chi Hsieh, Yee-Shin Lin, Trai-Ming Yeh, Hsiao-Sheng Liu, Dai-Di Gan
ETHNOPHARMACOLOGICAL RELEVANCE: Honeysuckle (Lonicera japonica Thunb.), a traditional Chinese herb, has widely been used to treat pathogen infection. However, the underlying-mechanism remains elusive. AIMS OF THE STUDY: To reveal the host microRNA (miRNA) profile with the anti-viral activity after honeysuckle treatment. MATERIALS AND METHODS: Here we reveal the differentially expressed miRNAs by Solexa(®) deep sequencing from the blood of human and mice after the aqueous extract treatment...
January 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28035106/zika-virus-infection-past-and-present-of-another-emerging-vector-borne-disease
#4
REVIEW
Hercules Sakkas, Vangelis Economou, Chrissanthy Papadopoulou
Zika virus infection is an emerging mosquito-borne disease, first identified in Uganda in 1947. It is caused by the Zika arbovirus, and transmitted by the bites of infected mosquitoes of the genus Aedes. For almost half a century, the Zika virus was reported as the causative agent of sporadic human infections. In 2007, the Zika virus emerged outside Asia and Africa causing an epidemic on the Island of Yap in Micronesia. The manifestation of the newly acquired human infection varies from asymptomatic to self-limiting acute febrile illness with symptoms and clinical features similar to those caused by the Dengue virus ('Dengue-like syndrome')...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28034555/impact-of-dengue-virus-serotype-denv-2-infection-on-liver-of-balb-c-mice-a-histopathological-analysis
#5
S Sakinah, Sivan Padma Priya, Sharmilah Kumari, Fatin Amira, Poorani K, Hiba Alsaeedy, Mok Pooi Ling, Hui-Yee Chee, Akon Higuchi, Abdullah A Alarfaj, Murugan A Munusamy, Kadarkarai Murugan, Che Norma Mat Taib, Palanisamy Arulselvan, Mariappan Rajan, Vasantha Kumari Neela, Rukman Awang Hamat, Giovanni Benelli, S Suresh Kumar
In this research, we characterized the histopathological impact of dengue virus (serotype DENV-2) infection in livers of BALB/c mice. The mice were infected with different doses of DENV-2 via intraperitoneal injection and liver tissues were processed for histological analyses and variation was documented. In the BALB/c mouse model, typical liver tissues showed regular hepatocyte architecture, with normal endothelial cells surrounding sinusoid capillary. Based on histopathological observations, the liver sections of BALB/c mice infected by DENV-2 exhibited a loss of cell integrity, with a widening of the sinusoidal spaces...
November 23, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/28031723/economic-report-on-the-cost-of-dengue-fever-in-vietnam-case-of-a-provincial-hospital
#6
Luyen Dinh Pham, Nhat Huy Tran Phung, Nguyen Tu Dang Le, Trung Quang Vo
BACKGROUND: Dengue is a mosquito-borne viral illness with the world's fastest rate of infection. In 2014, Vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. MATERIALS AND METHODS: A 6-month cross-sectional study was conducted from September 2015 to March 2016 at Cu Chi General Hospital. Cost of illness in this study was estimated under the incidence-based approach from the societal perspective. RESULTS: The average cost per case was US$139...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28029002/dengue-virus-serotypes-circulating-in-khyber-pakhtunkhwa-province-pakistan-2013-2015
#7
Muhammad Suleman, Rani Faryal, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Uzma Bashir Aamir, Adnan Khurshid, Mehar Angez, Massab Umair, Mian Muhammad Sufian, Yasir Arshad, Syed Sohail Zahoor Zaidi
From 2013 to 2015, the National Institute of Health, Pakistan, received 1,270 blood samples of suspected dengue cases reported from inpatient and outpatient departments of various hospitals in Khyber Pakhtunkhwa (KPK) province. In this study, we determined the circulating dengue virus (DENV) serotypes using real-time reverse transcriptase (RT)-PCR to understand the serotype-based epidemiology of DENV. All four serotypes (DENV-1 [6%], DENV-2 [33%], DENV-3 [47%], and DENV-4 [0.1%]) were found circulating during the study period...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28025597/clinical-profiles-of-dengue-infection-during-an-outbreak-in-northern-india
#8
Anish Laul, Poonam Laul, Vamsi Merugumala, Ravi Pathak, Urvashi Miglani, Pinkee Saxena
Introduction. Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28024241/what-caused-the-2012-dengue-outbreak-in-pucallpa-peru-a%C3%A2-socio-ecological-autopsy
#9
Margot Charette, Lea Berrang-Ford, Elmer Alejandro Llanos-Cuentas, César Cárcamo, Manisha Kulkarni
Dengue is highly endemic in Peru, with increases in transmission particularly since vector re-infestation of the country in the 1980s. Pucallpa, the second largest city in the Peruvian Amazon, experienced a large outbreak in 2012 that caused more than 10,000 cases and 13 deaths. To date, there has been limited research on dengue in the Peruvian Amazon outside of Iquitos, and no published review or critical analysis of the 2012 Pucallpa dengue outbreak. This study describes the incidence, surveillance, and control of dengue in Ucayali to understand the factors that contributed to the 2012 Pucallpa outbreak...
December 8, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28013374/mosquito-repellent-activity-of-volatile-oils-from-selected-aromatic-plants
#10
Lalthazuali, Nisha Mathew
Essential oils from fresh leaves of four aromatic plants viz., Ocimum sanctum, Mentha piperita, Eucalyptus globulus and Plectranthus amboinicus were extracted by hydrodistillation. The test solutions were prepared as 20% essential oil in ethanol and positive control as 20% DEET in ethanol. Essential oil blend was prepared as 5% concentration. Nulliparous, 3-5-day-old female adult Aedes aegypti mosquitoes were used for repellency screening as per ICMR protocol. The study showed that the repellency of 20% essential oil of O...
December 24, 2016: Parasitology Research
https://www.readbyqxmd.com/read/28009103/experts-perceptions-on-china-s-capacity-to-manage-emerging-and-re-emerging-zoonotic-diseases-in-an-era-of-climate-change
#11
A Hansen, J Xiang, Q Liu, M X Tong, Y Sun, X Liu, K Chen, S Cameron, S Hanson-Easey, G-S Han, P Weinstein, C Williams, P Bi
Zoonotic diseases transmitted by arthropods and rodents are a major public health concern in China. However, interventions in recent decades have helped lower the incidence of several diseases despite the country's large, frequently mobile population and socio-economic challenges. Increasing globalization, rapid urbanization and a warming climate now add to the complexity of disease control and prevention and could challenge China's capacity to respond to threats of emerging and re-emerging zoonoses. To investigate this notion, face-to-face interviews were conducted with 30 infectious disease experts in four cities in China...
December 23, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28003809/cytotoxic-cd4-t-cells-differentiation-function-and-application-to-dengue-virus-infection
#12
REVIEW
Yuan Tian, Alessandro Sette, Daniela Weiskopf
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV infection has not yet been fully successful due to lack of effective therapeutics or vaccines. Nevertheless, a better understanding of the immune responses against DENV infection may reveal new strategies for eliciting and improving antiviral immunity. T cells provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens and memory cells that can survive for long periods with enhanced abilities to control recurring pathogens...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28002420/the-impact-of-the-newly-licensed-dengue-vaccine-in-endemic-countries
#13
Maíra Aguiar, Nico Stollenwerk, Scott B Halstead
BACKGROUND: With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of uncomplicated dengue cases is only supportive and severe dengue cases require hospital intensive care. A vaccine now licensed in several countries and developed by Sanofi Pasteur (CYD-TDV, named Dengvaxia), was able to protect, in the first 25 months of the two Phase III, 66% of a subset of 9-16 year old participants...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27999305/mosquito-diptera-culicidae-habitat-surveillance-by-android-mobile-devices-in-guangzhou-china
#14
Tai-Ping Wu, Jun-Hua Tian, Rui-De Xue, Yi-Liang Fang, Ai-Hua Zheng
In 2014, Guangzhou City, South China, suffered from its worst outbreak of dengue fever in decades. Larval mosquito habitat surveillance was carried out by using android mobile devices in four study sites in May 2015. The habitats with larval mosquitoes were recorded as photo waypoints in OruxMaps or in videos. The total number of potential mosquito habitats was 342, of which 166 (49%) were found to have mosquito larvae or pupae. Small containers were the most abundant potential habitats, accounting for 26% of the total number...
December 17, 2016: Insects
https://www.readbyqxmd.com/read/27997936/a-review-of-recommendations-on-the-safe-and-effective-use-of-topical-mosquito-repellents
#15
Cameron E Webb, Isabel Mr Hess
Mosquito-borne disease is an annual problem in Australia, with endemic pathogens such as Ross River virus infecting thousands of people each year. The recent emergence of Zika virus in South America and the Pacific, together with ongoing outbreaks of dengue viruses in Southeast Asia, generated great community interest in the most effective strategies to avoid mosquito bites. Large-scale mosquito control programs are not common in Australia and are limited in New South Wales (NSW). The use of topical insect repellents is a key recommendation by health authorities to prevent mosquito-borne disease...
December 14, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27989728/mayaro-virus-a-forest-virus-primed-for-a-trip-to-the-city
#16
Ian M Mackay, Katherine E Arden
Mayaro virus (MAYV) is an emerging arthropod-borne virus (arbovirus). Infection by MAYV can produce Mayaro virus disease (MAYVD) which is usually a clinically diagnosed, acute, febrile illness associated with prolonged and painful joint inflammation and swelling. MAYVD may be clinically indistinguishable from dengue, chikungunya fever, malaria, rabies, measles or other arboviral diseases. The full spectrum of disease, sequelae, routes of infection, virus shedding and any rarer means of transmission remain undefined...
December 2016: Microbes and Infection
https://www.readbyqxmd.com/read/27982119/declining-prevalence-of-disease-vectors-under-climate-change
#17
Luis E Escobar, Daniel Romero-Alvarez, Renato Leon, Manuel A Lepe-Lopez, Meggan E Craft, Mercy J Borbor-Cordova, Jens-Christian Svenning
More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. In Ecuador, vector-borne diseases are present from coastal and Amazonian regions to the Andes Mountains; however, a detailed characterization of the distribution of their vectors has never been carried out. We estimate the distribution of 14 vectors of the above vector-borne diseases under present-day and future climates...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974667/molecular-determinants-of-human-neutralizing-antibodies-isolated-from-a-patient-infected-with-zika-virus
#18
Qihui Wang, Huabing Yang, Xiaoqing Liu, Lianpan Dai, Tong Ma, Jianxun Qi, Gary Wong, Ruchao Peng, Sheng Liu, Junfu Li, Shihua Li, Jian Song, Jianying Liu, Jianhua He, Hui Yuan, Ying Xiong, Yong Liao, Jianhua Li, Jianping Yang, Zhou Tong, Bryan D Griffin, Yuhai Bi, Mifang Liang, Xiaoning Xu, Chuan Qin, Gong Cheng, Xinzheng Zhang, Peiyi Wang, Xiangguo Qiu, Gary Kobinger, Yi Shi, Jinghua Yan, George F Gao
The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV...
December 14, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27942961/long-lasting-permethrin-impregnated-clothing-protective-efficacy-against-malaria-in-hyperendemic-foci-and-laundering-wearing-and-weathering-effects-on-residual-bioactivity-after-worst-case-use-in-the-rain-forests-of-french-guiana
#19
Bruno Most, Vincent Pommier de Santi, Frédéric Pagès, Marie Mura, Waltraud M Uedelhoven, Michael K Faulde
Personal protective measures against hematophagous vectors constitute the first line of defense against arthropod-borne diseases. However, guidelines for the standardized testing and licensing of insecticide-treated clothing are still lacking. The aim of this study was to analyze the preventive effect of long-lasting polymer-coated permethrin-impregnated clothing (PTBDU) against malaria after exposure to high-level disease transmission sites as well as the corresponding loss of permethrin and bioactivity during worst-case field use...
December 10, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27940911/climate-variation-drives-dengue-dynamics
#20
Lei Xu, Leif C Stige, Kung-Sik Chan, Jie Zhou, Jun Yang, Shaowei Sang, Ming Wang, Zhicong Yang, Ziqiang Yan, Tong Jiang, Liang Lu, Yujuan Yue, Xiaobo Liu, Hualiang Lin, Jianguo Xu, Qiyong Liu, Nils Chr Stenseth
Dengue, a viral infection transmitted between people by mosquitoes, is one of the most rapidly spreading diseases in the world. Here, we report the analyses covering 11 y (2005-2015) from the city of Guangzhou in southern China. Using the first 8 y of data to develop an ecologically based model for the dengue system, we reliably predict the following 3 y of dengue dynamics-years with exceptionally extensive dengue outbreaks. We demonstrate that climate conditions, through the effects of rainfall and temperature on mosquito abundance and dengue transmission rate, play key roles in explaining the temporal dynamics of dengue incidence in the human population...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
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