Wei Shi, Guang Xu, Yuan Gao, Huijie Yang, Tingting Liu, Jia Zhao, Hui Li, Ziying Wei, Xiaorong Hou, Yuanyuan Chen, Jincai Wen, Chengwei Li, Jun Zhao, Ping Zhang, Zhongxia Wang, Xiaohe Xiao, Zhaofang Bai
BACKGROUND: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) genes (STING) pathway is critical in the innate immune system and can be mobilized by cytosolic DNA. The various inflammatory and autoimmune diseases progression is highly correlated with aberrant cGAS-STING pathway activation. While some cGAS-STING pathway inhibitor were identified, there are no drugs that can be applied to the clinic. Compound Danshen Dripping Pill (CDDP) has been successfully used in clinic around the world, but the most common application is limited to cardiovascular disease...
March 7, 2024: Phytomedicine