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https://www.readbyqxmd.com/read/29156710/the-synergistic-antitumor-effect-of-cinobufagin-and-cisplatin-in-human-osteosarcoma-cell-line-in-vitro-and-in-vivo
#1
Guo Dai, Ling Yu, Jian Yang, Kezhou Xia, Zhengpei Zhang, Gaiwei Liu, Tian Gao, Weichun Guo
Cisplatin (CDDP) has been shown to be a promising anticancer drug that is effective against many types of cancer, which include osteosarcoma (OS). However, its therapeutic application is restricted by its toxicity in normal tissues and by side effects caused in patients. Reduction of the toxicity of CDDP is necessary to improve cancer treatment. In the present study, we attempted to clarify how cinobufagin, a traditional Chinese medicine, enhances CDDP-induced cytotoxicity in OS cells. OS 143B cells were treated with cinobufagin and CDDP alone or in combination...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155407/synthesis-of-porous-gdf3-er-3-yb-3-cooh-core-shell-structured-bi-functional-nanoparticles-for-drug-delivery
#2
Hongxia Peng, Ouyang Jundai, Jin Wen, Yangxi Peng
The authors synthesised porous GdF3:Er(3+),Yb(3+)-COOH core-shell structured bi-functional nanoparticles through a one-step hydrothermal route during which ethylene diamine tetraacetic acid) was bound to the surface of the nanoparticles. It has high up-conversion emission intensity for monitoring the drug release process and magnetisation saturation value (10.2 emu/g) for drug targeting under foreign magnetic fields. Moreover, porous GdF3:Er(3+),Yb(3+) as drug carriers with a high drug-loading efficiency...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155362/chemo-biologic-combinatorial-drug-delivery-using-folate-receptor-targeted-dendrimer-nanoparticles-for-lung-cancer-treatment
#3
Narsireddy Amreddy, Anish Babu, Janani Panneerselvam, Akhil Srivastava, Ranganayaki Muralidharan, Allshine Chen, Yan D Zhao, Anupama Munshi, Rajagopal Ramesh
Co-administration of functionally distinct anti-cancer agents has emerged as an efficient strategy in lung cancer treatment. However, a specially designed drug delivery system is required to co-encapsulate functionally different agents, such as a combination of siRNA and chemotherapy, for targeted delivery. We developed a folic acid (FA) -conjugated polyamidoamine dendrimer (Den) -based nanoparticle (NP) system for co-delivery of siRNA against HuR mRNA (HuR siRNA) and cis-diamine platinum (CDDP) to folate receptor-α (FRA) -overexpressing H1299 lung cancer cells...
November 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29153715/cisplatin-and-doxorubicin-high-loaded-nanodrug-based-on-biocompatible-thioether-and-ethane-bridged-hollow-mesoporous-organosilica-nanoparticles
#4
Junjie Zhang, Lixing Weng, Xiaodan Su, Guangming Lu, Wenfei Liu, Yuxia Tang, Yunlei Zhang, Jun Wen, Zhaogang Teng, Lianhui Wang
Herein, a mesoporous organosilica nanoparticle (MON) based nanodrug highly loaded with cisplatin (CDDP) and doxorubicin (DOX) (denoted as MONs/CDDP/DOX) has been successfully prepared for the first time. The MONs are characterized with core-contained double hollow shells, thioether and ethane groups separately incorporated frameworks, uniform diameter (420 nm), large surface area (592 m(2)/g), and ordered pore size (2.5 nm). The safety evaluation of the MONs based on cell viability, haemolytic activity, histological change, and serum biochemical index demonstrates that they have excellent biological compatibility...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29152741/neat1-acts-as-an-inducer-of-cancer-stem-cell-like-phenotypes-in-nsclc-by-inhibiting-egcg-upregulated-ctr1
#5
Pan Jiang, Aochang Chen, Xiaoyue Wu, Ming Zhou, Ijaz Ul Haq, Zahula Mariyam, Qing Feng
Long non-coding RNAs (lncRNAs) play significant roles in the pathogenesis of various cancers, including lung cancer. In this study, we aimed to investigate the biological function of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in cancer stem cells (CSCs). CSCs have been suggested as the main cause of tumor metastasis, tumor recurrence and chemotherapy resistance. The copper transporter 1 (CTR1) has been the focus of many recent studies because of its correlation with cisplatin (CDDP) resistance. So far, the mechanism of how NEAT1 regulates CSCs in NSCLC remains unknown...
November 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29151973/roles-of-micrornas-in-the-resistance-to-platinum-based-chemotherapy-in-the-non-small-cell-lung-cancer
#6
REVIEW
Hongjing Zang, Jianlun Peng, Weiyuan Wang, Songqing Fan
Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and sensitive NSCLC cells. Researches regarding microRNAs and their targets, in platinum drug resistant cases, illuminate novel ideals for platinum-based chemotherapy for NSCLC patients. Therefore, in this review we will focus on three aspects: Epithelial-mesenchymal transition (EMT), cell proliferation and apoptosis, and the roles of microRNAs in cisplatin (CDDP) and carboplatin (CBP) resistance...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29141405/injectable-thermo-sensitive-polypeptide-based-cddp-complexed-hydrogel-for-improving-localized-antitumor-efficacy
#7
Shuangjiang Yu, Dianliang Zhang, Chaoliang He, Wujin Sun, Rangjuan Cao, Shusen Cui, Mingxiao Deng, Zhen Gu, Xuesi Chen
In this study, a type of novel thermo-sensitive polypeptide-based hydrogel with tunable gelation behavior through changing the content of carboxyl groups was developed for the purpose of improving the cisplatin (CDDP) release behavior and enhancing the localized antitumor efficiency. The introduction of carboxyl groups in methoxy-poly(ethylene glycol)-b-(poly(γ-ethyl-L-glutamate-co-L-glutamic acid) (mPEG-b-P(ELG-co-LG)) not only led to adjustable mechanical properties of the hydrogel, but also significantly reduced the burst release of the drug through the complexation between the carboxyl groups of polypeptide and CDDP...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29132812/the-antitumor-effect-of-folic-acid-conjugated-auricularia-auricular-polysaccharide-cisplatin-complex-on-cervical-carcinoma-cells-in-nude-mice
#8
Junqiang Qiu, Hua Zhang, Zhenyu Wang, Didi Liu, Shumin Liu, Wei Han, Joe M Regenstein, Lin Geng
A tumor-targeted, folic acid (FA) conjugated-Auricularia auricular polysaccharide (AAP) -cis-diaminedichloroplatinum (CDDP) complex (FA-AAP-CDDP) was used for cervical carcinoma chemotherapy. The drug delivery system was able to enhance the antitumor potency of CDDP, and to reduce the toxic side effects of CDDP. The kidney of mice treated by FA-AAP-CDDP complex had higher superoxide dismutase, catalase, and glutathione peroxidase activities, and lower malondialdehyde. FA-AAP-CDDP complex could induce more interleukin-2, interleukin-4, and interferon-γ in mice...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29132040/inclusion-complexes-between-cisplatin-and-oxidized-carbon-nanostructures-a-theoretical-approach
#9
Leonardo A De Souza, Hélio F Dos Santos, Luciano T Costa, Wagner B De Almeida
The toxicity of inclusion compounds formed by carbon nanostructures depends on its functionalized surface, use of solvents, dosage and other properties. Molecular modeling has potentially contributed to the understanding of the chemical nature of the formation of these systems and allows advancement in studies of the mechanism of transport, release of drugs and their biological implications. This work reports a quantum chemical investigation of the inclusion complexes formation between oxidized carbon nanotube (CNTox)/nanocone (CNCox) structure and cisplatin molecule, using the density functional theory (DFT) with the B3LYP functional and 6-31G(d,p)/LanL2DZ standard basis sets...
November 3, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29131211/pharmaco-genomic-investigations-of-organo-iridium-anticancer-complexes-reveal-novel-mechanism-of-action
#10
Jessica M Hearn, George M Hughes, Isolda Romero-Canelón, Alison F Munro, Belén Rubio-Ruiz, Zhe Liu, Neil O Carragher, Peter J Sadler
Resistance to platinum drugs (used in >50% of cancer chemotherapies) is a clinical problem. Other precious metal complexes with distinct mechanisms of action might overcome this. Half-sandwich organometallic complexes containing arene or cyclopentadienyl (Cp) ligands show promise. We screened two iridium(iii) complexes [Ir(Cp(Xbiph))(ppy)Cl] (ZL49, 1, ppy = phenylpyridine) and [Ir(Cp(Xph))(azpyNMe2)Cl]PF6 (ZL109, 2, azpyNMe2 = N,N-dimethylphenylazopyridine) in 916 cancer cell lines from 28 tissue types. On average, complex 2 was 78× more potent than 1, 36× more active than cisplatin (CDDP), and strongly active (nanomolar) in patient-derived ovarian cancer cell lines...
November 13, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29130888/co-delivery-of-cisplatin-and-cjm-126-via-photothermal-conversion-nanoparticles-for-enhanced-synergistic-antitumor-efficacy
#11
Chaoqun You, Hongshuai Wu, Mingxin Wang, Zhiguo Gao, Xiangyang Zhang, Baiwang Sun
Polymeric biomaterials that can be smartly disassembled through the cleavage of the covalent bonds in a controllable method upon an environmental stimuli such as pH change, redox, special enzymes, temperature, ultrasound as well as light irradiation but otherwise are stable under physiological condition has attracted great attention in past decades. In our study, a novel NIR-responsive targeted binary-drug loaded nanoparticles encapsulating ICG dye was prepared as a new co-delivery and combined therapy vehicle...
November 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29125238/lncrna-uca1-promotes-proliferation-and-cisplatin-resistance-of-oral-squamous-cell-carcinoma-by-sunppressing-mir-184-expression
#12
Zheng Fang, Junfang Zhao, Weihong Xie, Qiang Sun, Haibin Wang, Bin Qiao
Chemotherapy resistance has become the main obstacle for the effective treatment of human cancers. Long non-coding RNA urothelial cancer associated 1 (UCA1) is generally regarded as an oncogene in some cancers. However, the function and molecular mechanism of UCA1 implicated in cisplatin (CDDP) chemoresistance of oral squamous cell carcinoma (OSCC) is still not fully established. UCA1 expression in tumor tissues and cells was tested by qRT-PCR. MTT, flow cytometry and caspase-3 activity analysis were explored to evaluate the CDDP sensitivity in OSCC cells...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29122704/comparing-the-different-response-of-pns-and-cns-injured-neurons-to-mesenchymal-stem-cell-treatment
#13
Marianna Monfrini, Maddalena Ravasi, Daniele Maggioni, Elisabetta Donzelli, Giovanni Tredici, Guido Cavaletti, Arianna Scuteri
Mesenchymal stem cells (MSCs) are adult bone marrow-derived stem cells actually proposed indifferently for the therapy of neurological diseases of both the Central (CNS) and the Peripheral Nervous System (PNS), as a panacea able to treat so many different diseases by their immunomodulatory ability and supportive action on neuronal survival. However, the identification of the exact mechanism of MSC action in the different diseases, although mandatory to define their real and concrete utility, is still lacking...
November 6, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29119204/benzalkonium-chloride-and-anticancer-drugs-in-binary-mixtures-reproductive-toxicity-and-genotoxicity-in-the-freshwater-crustacean-ceriodaphnia-dubia
#14
Chiara Russo, Michael Kundi, Margherita Lavorgna, Alfredo Parrella, Marina Isidori
Benzalkonium chloride (BAC) is a cationic surfactant commonly used as a disinfectant. Its ubiquitous nature is the result of high usage and frequent discharge into the environment and evidence of interaction with numerous contaminants, such as pharmaceutical active compound residues. Anticancer drugs, among these compounds, are able to exert eco-genotoxic effects at sub ng-µg/L. The purpose of this study was to assess the reproductive toxicity and the genotoxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), etoposide (ET), and imatinib mesylate (IM)-binary mixtures combined with BAC in Ceriodaphnia dubia...
November 8, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29117859/a-novel-chemotherapeutic-sensitivity-testing-system-based-on-collagen-gel-droplet-embedded-3d-culture-methods-for-hepatocellular-carcinoma
#15
Jun Hou, Zhixian Hong, Fan Feng, Yantao Chai, Yunkai Zhang, Qiyu Jiang, Yan Hu, Shunquan Wu, Yingsong Wu, Xunian Gao, Qiong Chen, Yong Wan, Jingfeng Bi, Zheng Zhang
BACKGROUND: Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, it is urgent to develop a new chemotherapeutic sensitivity testing system for HCC treatment. The presence study investigated the potential application of a novel chemotherapeutic sensitivity-testing system based on a collagen gel droplet embedded 3D-culture system (CD-DST)...
November 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29116098/chemodrug-delivery-using-integrin-targeted-plga-chitosan-nanoparticle-for-lung-cancer-therapy
#16
Anish Babu, Narsireddy Amreddy, Ranganayaki Muralidharan, Gopal Pathuri, Hariprasad Gali, Allshine Chen, Yan D Zhao, Anupama Munshi, Rajagopal Ramesh
In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 receptor targeted paclitaxel (PTX) delivery in lung cancer cells and its impact on normal cells. RGD peptide-modified chitosan was synthesized and then coated onto PTX-PLGA nanoparticles prepared by emulsion-solvent evaporation. PTX-PLGA-CSNP-RGD displayed favorable physicochemical properties for a targeted drug delivery system...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108228/cbp501-induces-immunogenic-tumor-cell-death-and-cd8-t-cell-infiltration-into-tumors-in-combination-with-platinum-and-increases-the-efficacy-of-immune-checkpoint-inhibitors-against-tumors-in-mice
#17
Keiichi Sakakibara, Takuji Sato, Donald W Kufe, Daniel D VonHoff, Takumi Kawabe
CBP501, a calmodulin-binding peptide, is an anti-cancer drug candidate and functions as an enhancer of platinum uptake into cancer cells. Here we show that CBP501 promotes immunogenic cell death (ICD) in combination with platinum agents. CBP501 enhanced a clinically relevant low dose of cisplatin (CDDP) in vitro as evidenced by upregulation of ICD markers, including cell surface calreticulin exposure and release of high-mobility group protein box-1. Synergistic induction of ICD by CDDP plus CBP501 as compared to CDDP alone was confirmed in the well-established vaccination assay...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103255/-two-cases-of-urachal-carcinoma-treated-by-ts-1-cddp-as-adjuvant-chemotherapy
#18
Michinobu Ozawa, Akito Kuromoto, Kento Morozumi, Masahiko Satou, Senji Hoshi, Kenji Numahata
Case 1 : A 48-year-old man presenting with gross hematuria was suspected to have a tumor located in the bladder dome. He was referred to our department for further examination and treatment. Cystoscopy showed a dome-shaped mass in the supravesical region. Computed tomography and magnetic resonance imaging indicated the possibility of urachal carcinoma and peritoneal dissemination. Therefore, partial cystectomy with urachal resection was performed. The intraoperative findings were disseminated peritoneal nodules and mucus entering the peritoneal cavity from the tumor...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29093343/alterations-in-cisplatin-pharmacokinetics-and-its-acute-sub-chronic-kidney-injury-over-multiple-cycles-of-cisplatin-treatment-in-rats
#19
Akira Okada, Keizo Fukushima, Mai Fujita, Mana Nakanishi, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Nobuyuki Sugioka
Cisplatin (CDDP)-induced acute kidney injury (AKI) is a major clinical concern. CDDP treatment is generally conducted with multiple cycles; the magnitude of the CDDP-induced AKI may be altered by these cycles. Moreover, sub-chronic kidney injury (sCKI) induced by repeated CDDP treatment is often associated with renal interstitial fibrosis, potentially leading to chronic kidney disease. Therefore, it is suggested that the management of not only AKI but also sCKI induced by CDDP in multiple cycles plays an important role in the outcome of CDDP-based chemotherapy...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29081817/compound-danshen-dripping-pill-for-treating-nonproliferative-diabetic-retinopathy-a-meta-analysis-of-13-randomized-controlled-trials
#20
REVIEW
Wenjing Huang, Qi Bao, De Jin, Fengmei Lian
OBJECTIVE: We assess the clinical effect of compound Danshen dripping pill (CDDP) for treating diabetic retinopathy (DR). METHODS: Electronic databases were searched from January 2001 to October 2016 to locate randomized controlled trials (RCTs). Efficacy was measured as main outcome and microaneurysms, hemorrhage, exudate, vision, and fundus fluorescein angiography (FFA) were measured as second outcomes. Methodological quality for each study was evaluated, RevMan 5 software was used to assess treatment effects, and GRADE was used to rate quality of evidence...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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