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https://www.readbyqxmd.com/read/29767247/comparison-of-the-synergistic-anticancer-activity-of-alpcs4-photodynamic-therapy-in-combination-with-different-low%C3%A2-dose-chemotherapeutic-agents-on-gastric-cancer-cells
#1
Jing Xin, Senhao Wang, Luwei Zhang, Bo Xin, Yulu He, Jing Wang, Sijia Wang, Lijian Shen, Zhenxi Zhang, Cuiping Yao
Limited cellular delivery and internalization efficiency of Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) induce poor penetration ability in cells and a slight photodynamic therapy (PDT) effect on gastric cancer. The combination treatment of AlPcS4/PDT with low‑dose chemotherapeutic agents may provide a promising treatment strategy to increase the weak delivery efficiency of AlPcS4, reducing the dose of chemical agents without reducing efficacy, and improving apoptosis‑inducing abilities, thereby increasing the antitumor effects and decreasing the noxious side effects on gastric cancer...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29765771/reduction-in-nephrotoxicities-using-short-hydration-for-chemotherapy-containing-cisplatin-a-consecutive-analysis-of-467-patients-with-thoracic-malignancies
#2
Midori Tanaka, Hidehito Horinouchi, Yasushi Goto, Shintaro Kanda, Yutaka Fujiwara, Hiroshi Nokihara, Noboru Yamamoto, Yuichiro Ohe
Background: Conventional hydration (CH) in chemotherapy containing cisplatin (CDDP) has been recommended to prevent renal toxicity. Although an increasing number of studies have demonstrated the feasibility of short hydration (SH), few large studies have reported the superiority of SH, compared with CH, in terms of nephrotoxicities. Methods: We conducted a consecutive retrospective analysis of 467 patients who had been treated with chemotherapy including CDDP. Statistical analyses were performed to evaluate the risk factors for nephrotoxicities...
2018: ESMO Open
https://www.readbyqxmd.com/read/29765522/establishment-of-preclinical-chemotherapy-models-for-gastroenteropancreatic-neuroendocrine-carcinoma
#3
Akihiro Ohmoto, Masami Suzuki, Erina Takai, Hirofumi Rokutan, Yuko Fujiwara, Chigusa Morizane, Kazuyoshi Yanagihara, Tatsuhiro Shibata, Shinichi Yachida
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a rare and devastating malignancy, and preclinical studies are needed to evaluate potential therapeutic regimens. Here, we examined the antitumor effects of cisplatin (CDDP), etoposide (ETP) and irinotecan (CPT-11) and their combinations on GEP-NEC using three small-cell GEP-NEC cell lines (pancreatic NEC, A99; esophageal NEC, TYUC-1; duodenum NEC, TCC-NECT-2). In vitro studies were conducted using cell viability assays. In vivo experiments were conducted in mice inoculated with A99 or TCC-NECT-2 and treated with no agent, CDDP, CDDP+ETP (EP) or CDDP+CPT-11 (IP)...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29750897/involvement-of-ffa1-and-ffa4-in-the-regulation-of-cellular-functions-during-tumor-progression-in-colon-cancer-cells
#4
Kaede Takahashi, Kaori Fukushima, Yuka Onishi, Kanako Minami, Shiho Otagaki, Kaichi Ishimoto, Nobuyuki Fukushima, Kanya Honoki, Toshifumi Tsujiuchi
Free fatty acid receptor 1 (FFA1) and FFA4 mediate a variety of biological responses through binding of medium- and long-chain free fatty acids. The aim of this study was to investigate an involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells. The long-term fluorouracil (5-FU) and cisplatin (CDDP) treated cells were generated from DLD1 cells (DLD-5FU and DLD-CDDP cells, respectively). FFAR1 expressions were lower in DLD-5FU and DLD-CDDP cells than in DLD1 cells...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29750018/inactivation-of-nuclear-factor-%C3%AE%C2%BAb-by-mip-based-drug-combinations-augments-cell-death-of-breast-cancer-cells
#5
Menaga Subramaniam, Su Ki Liew, Lionel LA In, Khalijah Awang, Niyaz Ahmed, Noor Hasima Nagoor
Background: Drug combination therapy to treat cancer is a strategic approach to increase successful treatment rate. Optimizing combination regimens is vital to increase therapeutic efficacy with minimal side effects. Materials and methods: In the present study, we evaluated the in vitro cytotoxicity of double and triple combinations consisting of 1'S-1'-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP) and cisplatin (CDDP) against 14 various human cancer cell lines to address the need for more effective therapy...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29747775/expression-and-significance-of-aspp2-in-squamous-carcinoma-of-esophagus
#6
Bo Liu, Lv Yang, Xiu-Juan Li, Rou Li, Wei Sun, Xiao-Yi Chen, Jun-Chao Liu
To study the significance of apoptosis stimulating protein of P53 2 (ASPP2) expression in esophageal squamous cell carcinoma (ESCC), immunohistochemistry S-P method was used to examine the expression of ASPP2 in 136 cases of ESCC, 35 cases of high grade intraepithelial neoplasia (HGIN), 29 cases of low grade intraepithelial neoplasia (LGIN) and 37 cases of normal esophageal epithelium (NEE). The associations of ASPP2 expression with clinicopathological data and overall survival (OS) were also analyzed. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to evaluate ASPP2 expression in a total of 20 matched human ESCC tumor tissues and normal adjacent tissues (NAT)...
June 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731891/synergistic-effects-of-cisplatin-caffeic-acid-induces-apoptosis-in-human-cervical-cancer-cells-via-the-mitochondrial-pathways
#7
Amonrat Koraneekit, Temduang Limpaiboon, Arunnee Sangka, Patcharee Boonsiri, Sakda Daduang, Jureerut Daduang
Cervical cancer (CxCa) is a major health problem globally and is associated with the presence of human papillomavirus infection. Cisplatin (CDDP) is a platinum-based chemotherapeutic agent. Owing to its side effects and drug-resistance, novel anticancer agents with lower toxicity, including caffeic acid (CFC), are of interest. However, the effects of CDDP and CFC in combination are, to the best of our knowledge, uninvestigated. The present study investigated the effectiveness of CDDP and CFC in combination and its mechanism of action on four human cervical cancer cell lines, which were compared with the Chlorocebus sabaeus normal kidney Vero cell line...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29730175/cisplatin-and-curcumin-co-loaded-nano-liposomes-for-the-treatment-of-hepatocellular-carcinoma
#8
Yao Cheng, Pengxuan Zhao, Shuangping Wu, Tan Yang, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Chao Zheng, Kelin Li, Xiang Ma, Guangya Xiang
Hepatocellular carcinoma (HCC) continues to be a leading cause of cancer related death in the world. Conventional chemotherapeutic agents such as cisplatin (CDDP) have an unsatisfactory efficacy on HCC due to the poor response, severe toxicity and drug resistance. Curcumin (CUR) could improve the chemosensitivity of HCC to chemotherapy drugs by regulating a variety of signaling pathways. Herein, we describe a combination strategy using co-loaded liposomes to effectively deliver and release CDDP and curcumin (CUR) to HCC for overcoming the unsatisfactory clinical outcome of CDDP monotherapy...
May 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29721093/graphene-oxide-sensitizes-cancer-cells-to-chemotherapeutics-by-inducing-early-autophagy-events-promoting-nuclear-trafficking-and-necrosis
#9
Kuan-Chen Lin, Mei-Wei Lin, Mu-Nung Hsu, Guan Yu-Chen, Yu-Chan Chao, Hsing-Yu Tuan, Chi-Shiun Chiang, Yu-Chen Hu
Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to CDDP impedes its wide use for cancer therapy. Autophagy is an event occurring in the cytoplasm and cytoplasmic LC3 puncta formation is a hallmark of autophagy. Graphene oxide (GO) is a nanomaterial that provokes autophagy in CT26 colon cancer cells and confers antitumor effects. Here we aimed to evaluate whether combined use of GO with CDDP (GO/CDDP) overcomes chemoresistance in different cancer cells and uncover the underlying mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29710459/inhibitory-effect-of-chidamide-on-the-growth-of-human-adenoid-cystic-carcinoma-cells
#10
Sheng Yang, Peng Nan, Chunxiao Li, Feng Lin, Hui Li, Ting Wang, Chunxia Zhou, Xueyan Zhang, Xiting Meng, Haili Qian, Haijuan Wang, Mei Dong
Adenoid cystic carcinoma (ACC) is a malignant epithelial neoplasm that limitedly responses to chemotherapy at the cost of significant toxicity. There is no single targeted drug approved by Food and Drug Administration (FDA) for ACC. Genomic landscape studies have revealed that frequently mutated pathways in ACC often involve in chromatin remodeling, which interfere multiple histone related proteins. Chidamide is a novel histone deacetylase inhibitor (HDACi) approved in clinical practice that was designed to increase the acetylation level of histone H3...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29707994/high-expression-of-aurora-b-is-correlated-with-poor-prognosis-and-drug-resistance-in-non-small-cell-lung-cancer
#11
JingJing Yu, Jing Zhou, Fei Xu, Wei Bai, Wei Zhang
OBJECTIVE: Aurora kinase B (Aurora-B) is a crucial regulator of accurate mitosis. Abnormal Aurora-B expression is associated with aneuploidy and has been implicated in the pathogenesis and drug resistance in a variety of human cancers. However, little evidence is available regarding the role of Aurora-B in regulating drug response in non-small cell lung cancer (NSCLC), which is the most common type of lung cancer, and is characterized with poor prognosis and high mortality. METHOD: In the current study, we investigated the association of Aurora-B with the prognosis of NSCLC patients, and we also used the latest CRISPR/Cas9 system to explore the regulatory role of Aurora-B in NSCLC cells developing resistance to cisplatin (CDDP) and paclitaxel...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29697201/mir-1307-regulates-cisplatin-resistance-by-targeting-mdm4-in-breast-cancer-expressing-wild-type-p53
#12
Xinyan Wang, Jianwei Zhu
BACKGROUND: Many chemotherapy regimens are used to treat breast cancer; however, breast cancer cells often develop drug resistance that usually leads to relapse and poor prognosis. MicroRNAs (miRNAs) are short non-coding RNA molecules that post-transcriptionally regulate gene expression and play crucial roles in diverse biological processes, such as development, differentiation, apoptosis, and proliferation. We investigated the roles of miRNAs in the development of drug resistance in human breast cancer cells...
April 26, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29690935/combination-therapy-involving-radiofrequency-ablation-and-targeted-chemotherapy-with-bevacizumab-plus-paclitaxel-and-cisplatin-in-a-rabbit-vx2-lung-tumor-model
#13
Ai Ueki, Tomohisa Okuma, Shinichi Hamamoto, Ken Kageyama, Kazuki Murai, Yukio Miki
OBJECTIVE: Radiofrequency ablation (RFA) is less effective for large tumors > 3 cm in diameter. Various studies of combination therapy using RFA and other treatments have been conducted to improve the results of RFA treatment of lung tumors, survival was extended in a tumor model when RFA was followed by concomitant use of systemic chemotherapy. Bevacizumab (BCM) is a one of molecular target drugs. Numerous clinical trials and reports have shown BCM's effect when used in combination with cisplatin (CDDP) in lung tumor...
April 24, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29679292/preparation-and-optimization-lipid-nanocapsules-to-enhance-the-antitumor-efficacy-of-cisplatin-in-hepatocellular-carcinoma-hepg2-cells
#14
Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang
This work aimed to develop and optimize several lipid nanocapsule formulations (LNCs) to encapsulate cisplatin (CDDP) for treatment of hepatocellular carcinoma. By comparing the effect of oil/surfactant ratio, lecithin content, and oil/surfactant type on LNC characteristics, two LNCs were selected as optimal formulations: HS15-LNC (Solutol HS 15/MCT/lecithin, 54.5:42.5:3%, w/w) and EL-LNC (Cremophor EL/MCT/lecithin, 54.5:42.5:3%, w/w). Both LNCs could effectively encapsulate CDDP with the encapsulation efficiency of 73...
April 20, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29650911/-a-case-of-advanced-gastric-cancer-with-multiple-liver-metastases-treated-with-curative-conversion-therapy-after-s-1-plus-cddp
#15
Yukito Shindo, Shinichiro Fukuda, Ryoko Kataoka, Nobutsuna Kuwamoto, Hitomi Takaishi, Yasuaki Miura, Ryoichi Hirayama, Ryo Otsuka, Shuji Saito, Rikiya Fujita
A57 -year-old man was diagnosed with advanced gastric cancer(adenocarcinoma[tub2/por1])with multiple(S3, S4, S5, S6, S8)liver and para-aortic lymph node metastases. The tumor was classified as cT4a, N3, M1, HEP, cStage IV, and the patient received chemotherapy with S-1 plus CDDP(SP). After 10 courses of SP, a CT scan revealed that the primary tumor and the metastases disappeared. The patient presented with cCR and underwent distal gastrectomy, D2 lymph node dissection, partial hepatic resection, and cholecystectomy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650908/-advanced-gastric-cancer-with-peritoneal-dissemination-treated-with-conversion-surgery-after-s-1-and-cddp-chemotherapy-a-case-report
#16
Yoshiko Matsuda, Tetsu Nakamura, Koji Ueta, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Taro Oshikiri, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji
A 27-year-old woman was diagnosed with gastric cancer complicated peritoneal dissemination and direct invasion to pancreas via staging laparoscopy. After systemic chemotherapy using regimen of S-1/CDDP for 2courses, the tumor did not increase in size and peritoneal dissemination did not progress. The patient subsequently underwent distal gastrectomy as a curative surgery. The histological diagnosis was ypT4bN1M0, ypStage III B. The patient was treated with DOC/CDDP for 6 courses after surgery as adjuvant therapy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650894/-chemoradiotherapy-the-standard-treatment-at-present
#17
Sadamoto Zenda
Chemotherapy concurrent with radiotherapy has been widely used in clinical practice because the additional benefit on radiotherapy alone had shown. Head and neck cancer: CDDP concurrent with radiotherapy has been a standard treatment for 15years both in definitive setting and postoperative setting. Esophageal cancer: 5-FU/CDDP is the best partner for radiotherapy and appropriate radiation dose has been discussed. Anal cancer: Radical concurrent chemoradiotherapy with 5-FU and mitomycin C(MMC)remains the standard of care for squamous cell carcinoma of the anus...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650855/-a-case-of-double-cancer-of-intrahepatic-cholangiocarcinoma-and-gastric-carcinoma-with-difficult-diagnosis-of-the-primary-tumor-with-peritoneal-metastasis
#18
Hiroyuki Kanomata, Yasuji Seyama, Hiroki Kudo, Toru Tanizawa, Masahiro Warabi, Masamichi Takahashi, Yujiro Matsuoka, Ikuo Wada, Masayuki Takegami, Yukio Miyamoto, Nobutaka Umekita
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1>tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm)...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650841/-a-case-of-advanced-esophageal-cancer-successfully-treated-with-multidisciplinary-therapy
#19
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Masateru Okawa, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Naruyasu Kakita, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
We report a case of advanced esophageal cancer that was successfully treated using chemotherapy, operation, and chemoradiotherapy. A 66-year-old man with advanced esophageal cancer(Mt, O-Is, T4[N0.7-stomach], N2, M0, Stage III)was administered chemotherapy(docetaxel[DOC], cisplatin[CDDP], and 5-fluorouracil[5-FU]: DCF). As the esophageal tumor achieved complete clinical response after 2 courses of chemotherapy, lymph node dissection and proximal gastrectomy were performed for the residual tumor. Abdominal CT 3 months after surgery revealed lymph node swelling...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650839/-a-case-of-splenic-metastasis-from-serous-surface-papillary-carcinoma-of-the-peritoneum-treated-by-laparoscopic-splenectomy
#20
Yongkook Kim, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Junji Kawada, Miho Okano, Masaki Okuyama, Takeshi Yokoi, Masaru Yamasaki, Toshimasa Tsujinaka
A 50-year-old woman with abdominal fullness, lower abdominal pain, elevated serum CA125, and ascites, underwent neoadjuvant chemotherapy with 6 courses of PTX/CBDCA followed by total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and intrapelvic peritoneal stripping based on a diagnosis of serous surface papillary carcinoma(SSPC) of the peritoneum. Complete response(CR)was shown after adjuvant chemotherapy with 3 courses of the same regimen. After 6 months, serum CA125 level re-increased and abdominal CT showed small low density areas in the patient's spleen and the perisplenic fat tissue...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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