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https://www.readbyqxmd.com/read/28723652/a-patient-derived-orthotopic-xenograft-pdox-mouse-model-of-a-cisplatinum-resistant-osteosarcoma-lung-metastasis-that-was-sensitive-to-temozolomide-and-trabectedin-implications-for-precision-oncology
#1
Kentaro Igarashi, Takashi Murakami, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Yong Zhang, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jane Yanagawa, Tara A Russell, Arun S Singh, Hiroyuki Tsuchiya, Irmina Elliott, Fritz C Eilber, Robert M Hoffman
In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy. Osteosarcoma resected from the patient was implanted orthotopically in the distal femur of mice to establish PDOX models which were randomized into the following groups when tumor volume reached approximately 100 mm3: G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal injection, weekly, for 2 weeks); G3, TRAB (0...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28717059/pharmacological-effects-of-a-vitamin-k1-2-3-epoxide-reductase-vkor-inhibitor-3-acetyl-5-methyltetronic-acid-on-cisplatin-induced-fibrosis-in-rats
#2
Masashi Uchida, Tomoya Miyoshi, Yohei Miyamoto
Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited by its severe side effects in the kidneys. Glomerular and tubular injuries in the kidneys commonly progress to interstitial fibrosis and, ultimately, the end stage of renal failure. We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats...
July 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28707541/concurrent-weekly-cisplatin-versus-triweekly-cisplatin-with-radiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-cervix-a-retrospective-analysis-from-a-single-institution
#3
Yoshino Kinjyo, Yutaka Nagai, Takafumi Toita, Wataru Kudaka, Takuro Ariga, Yuko Shimoji, Tadaharu Nakasone, Yusuke Taira, Yoshihisa Arakaki, Tomoko Nakamoto, Akihiko Wakayama, Takuma Ooyama, Hitoshi Maemoto, Joichi Heianna, Yoichi Aoki
OBJECTIVES: To compare patients with cervical cancer who were primarily treated with concurrent chemoradiotherapy (CCRT) using 20 mg/m(2) CCDP for 5 days every 3 weeks with weekly regimens of 40 mg/m(2). METHODS: We retrospectively analyzed 185 patients with Stage IB to IVA squamous cell carcinoma of the cervix who were treated with CCRT between 2005 and 2013 at our hospital. The CCRT regimen consisted of cisplatin at 20 mg/m(2) for 5 days every 3 weeks or 40 mg/m(2) weekly, administered concomitantly with RT...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28700356/a-novel-anionic-phosphate-platinum-complex-effectively-targets-an-undifferentiated-pleomorphic-sarcoma-better-than-cisplatinum-and-doxorubicin-in-a-patient-derived-orthotopic-xenograft-pdox
#4
Kentaro Igarashi, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Scott D Nelson, Sarah M Dry, Yunfeng Li, Arun S Singh, Shinji Miwa, Akira Odani, Fritz C Eilber, Hiroyuki Tsuchiya, Robert M Hoffman
A patient high-grade undifferentiated pleomorphic soft-tissue sarcoma (UPS) from a striated muscle was previously orthotopically implanted in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) nude-mouse model. In the present study, two weeks after orthotopic transplantation of the UPS, mice were treated intraperitoneally with cisplatinum (CDDP), doxorubicin (DOX) or a novel anionic-phosphate-platinum compound 3Pt. Treatments were repeated weekly for a total of 3 times...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698447/-a-case-of-perianal-squamous-cell-carcinoma-with-left-inguinal-lymph-node-metastasis-that-showed-a-complete-response-more-than-five-years-after-chemotherapy-and-concomitant-proton-beam-therapy
#5
Nobuyasu Suzuki, Ayaka Azami, Yukitoshi Todate, Takeshi Tada, Mitsuru Waragai, Michitaka Honda, Atai Sato, Yoshinao Takano, Tsuyoshi Abe, Tatsuya Nakamura, Yasushi Teranishi
We report a case of perianal squamous cell carcinoma and left inguinal lymph node metastasis that showed a complete response more than 5 years after chemotherapy and concomitant proton beam therapy. A 34-year-old woman was referred to our hospital for an anal tumor and a left inguinal tumor. A digital rectal examination revealed a tumor in the anterior wall of the anal canal. In addition, the left inguinal lymph nodes were swollen, leading us to suspect metastases. Biopsy specimens confirmed poorly differentiated squamous cell carcinoma...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28696828/small-molecule-inhibitor-tw-37-is-tolerable-and-synergistic-with-chemotherapy-in-nasopharyngeal-carcinoma
#6
Ying Lu, Haixin Huang, Hui Yang, Dagui Chen, Sibei Wu, Zhou Jiang, Rensheng Wang
Chemotherapy is a crucial adjuvant therapy of advanced nasopharyngeal carcinoma (NPC). However, enhancing sensitivity and tolerance of chemotherapeutics in NPC treatment have been challenging. Both Bcl-2 and Mcl-1, 2 pro-survival proteins of Bcl-2 family, play essential roles on the chemotherapy tolerance of numerous cancers. In the present study, we explored the influences of TW-37, a small molecule inhibitor of Bcl-2 and Mcl-1, on the efficiency of chemotherapy for NPC. Oncomine cancer database shows that NPC tissues have higher expression of Bcl-2 and Mcl-1 than those of normal nasopharyngeal epithelial (NPE) tissues...
July 11, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28693382/mir-7-increases-cisplatin-sensitivity-of-gastric-cancer-cells-through-suppressing-mtor
#7
Ning Xu, Yan-Jun Lian, Xiang Dai, Yuan-Jie Wang
MicroRNAs have been reported to play an important role in diverse biological processes and cancer progression. MicroRNA-7 has been observed to be downregulated in human gastric cancer tissues, but the function of microRNA-7 in gastric cancer has not been well investigated. In this study, we demonstrate that the expression of microRNA-7 was significantly downregulated in 30 pairs of human gastric cancer tissues compared to adjacent normal tissues. Enforced expression of microRNA-7 inhibited cell proliferation and migration abilities of gastric cancer cells, BGC823 and SGC7901...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28689961/pregabalin-reduces-cisplatin-induced-mechanical-allodynia-in-rats
#8
Yoshihiro Seto, Miyuki Takase, Yasuhiro Tsuji, Hideto To
Although cisplatin (CDDP) is a key drug in cancer chemotherapy, CDDP-induced peripheral neuropathy is a dose-limiting factor. We previously reported that CDDP-induced peripheral neuropathy, which progressed from allodynia to hypoalgesia, was ameliorated by the administration of CDDP to rats at a specific time. However, mechanical allodynia cannot be prevented therapeutically. Pregabalin (PGN) is used to suppress neuropathic pain from herpes zoster and diabetes. Therefore, we investigated the effects of PGN on CDDP-induced mechanical allodynia in rats...
June 20, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28686330/gstp1-c-313a-g-xpd-c-934g-a-xpf-c-2505t-c-and-casp9-c-1339a-g-polymorphisms-and-severity-of-vomiting-in-head-and-neck-cancer-patients-treated-with-cisplatin-chemoradiation
#9
Juliana Carron, Leisa Lopes-Aguiar, Ericka Francislaine Dias Costa, Guilherme Augusto Silva Nogueira, Tathiane Regine Penna Lima, Eder Carvalho Pincinato, Marilia Berlofa Visacri, Júlia Coelho França Quintanilha, Patrícia Moriel, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima
Cisplatin (CDDP) chemotherapy associated with radiation (RT) has been used in advanced head and neck squamous cell carcinoma (HNSCC) patients, and vomiting is a common side effect during treatment. This prospective study aimed to identify the roles of GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G, XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C, ERCC1 c.354C>T, MLH1 c.-93G>A, MSH2 c.211+9C>G, MSH3 c.3133G>A, EXO1 c.1765G>A, TP53 c.215G>C, CASP3 c.-1191A>G and c...
July 7, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28682411/coordination-self-assembly-of-platinum-bisphosphonate-polymer-metal-complex-nanoparticles-for-cisplatin-delivery-and-effective-cancer-therapy
#10
Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao
Cisplatin (CDDP) is a potent anti-carcinogen that is widely used for various solid tumors; however, its clinical application is limited by its severe nephrotoxicity. Novel platinum-bisphosphonate polymer-metal complex nanoparticles (Pt-bp NPs), based on platinum-bisphosphonate coordination, have been established. Three polymer carriers bearing alendronate (ALN) ligands, while containing different lengths of alkyl hydrophobic chains, were synthesized. Their structures were characterized by (1)H NMR, (31)P NMR and FTIR...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28677094/bisdemethoxycurcumin-sensitizes-cisplatin-resistant-lung-cancer-cells-to-chemotherapy-by-inhibition-of-ca916798-and-pi3k-akt-signaling
#11
Hai-Jing Wang, Zai-Xing Yang, Xiao-Tian Dai, Yong-Feng Chen, He-Ping Yang, Xiang-Dong Zhou
Curcumin, a dietary supplement or herbal medicine from Curcuma longa, has shown antitumor activity in different cancer cell lines and clinical trials. CA916798, a novel protein, is overexpressed in multidrug-resistant tumor cells. This study aimed to assess the effects of curcumin on regulating chemosensitivity in cisplatin-resistant non-small cell lung cancer (NSCLC) cells in vitro and to explore the underlying molecular mechanisms. Human cisplatin-sensitive A549 and cisplatin-resistant A549/CDDP lung adenocarcinoma cells were treated with curcumin to assess cell viability and gene modulations using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting...
July 4, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28670892/age-and-gender-related-renal-side-effects-of-cisplatin-in-animal-model
#12
Zahra Pezeshki, Maryam Maleki, Ardeshir Talebi, Mehdi Nematbakhsh
Backgrounds: Cisplatin (CDDP) is a choice of anti-cancer drug for cancer chemotherapy with serious side effects such as nephrotoxicity. It seems that age is an important factor influencing the side effects of CDDP. This study was designed to determine the role of age and gender simultaneously in CDDP induced renal toxicity. Methods: 40 Wistar male and female rats were assigned as 6 groups in 3 different age categories (10, 16, and 20 weeks old). The single dose of CDDP (7.5 mg/kg, ip) was administrated, and a week later measurements were performed...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28667026/htra1-down-regulation-induces-cisplatin-resistance-in-colon-cancer-by-increasing-xiap-and-activating-pi3k-akt-pathway
#13
Zhenfang Xiong, Zhonghua Fu, Jun Shi, Xiaozhen Jiang, Hongping Wan
The high temperature requirement factor A1 (HtrA1), a member of serine protease family, has been reported to be down-regulated in various cancer types and correlate with chemoresistance. However, the function of HtrA1 in colon cancer remains unclear. This study investigated the role of HtrA1 in cisplatin (CDDP) resistance of colon cancer. We found that HtrA1 was up-regulated in colon cancer cell line SW480 incubated with CDDP. By treating SW480 cells to a continuous exposure to CDDP, we developed CDDP-resistant SW480/CDDP cells and found that the mRNA and protein levels of HtrA1 were reduced...
May 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28666729/crgd-peptide-installation-on-cisplatin-loaded-nanomedicines-enhances-efficacy-against-locally-advanced-head-and-neck-squamous-cell-carcinoma-bearing-cancer-stem-like-cells
#14
Kazuki Miyano, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Yuki Mochida, Hiroaki Kinoh, Caname Iwata, Osamu Nagano, Hideyuki Saya, Nobuhiro Nishiyama, Kazunori Kataoka, Tatsuya Yamasoba
Recalcitrant head and neck squamous cell carcinoma (HNSCC) usually relapses after therapy due to the enrichment of drug resistant cancer stem-like cells (CSCs). Nanomedicines have shown potential for eradicating both cancer cells and CSCs by effective intratumoral navigation for reaching particular cell populations and controlling drug delivery. The installation of ligands on nanomedicines is an attractive approach for improving the delivery to CSCs within tumors, though the development of CSC-selective ligand-receptor systems has been challenging...
June 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28653877/long-non-coding-rna-tumor-suppressor-candidate-7-advances-chemotherapy-sensitivity-of-endometrial-carcinoma-through-targeted-silencing-of-mir-23b
#15
Chao Shang, Bin Lang, Cheng Ngok Ao, Lirong Meng
Endometrial carcinoma is the most common malignant tumor of the female genital tract worldwide. TUSC7 (tumor suppressor candidate 7) is an antisense long non-coding RNA and is downregulated and acts as a potential tumor suppressor in several malignant tumors. In this study, the low expression of TUSC7 was confirmed in endometrial carcinoma tissues and was associated with high pathological stages of endometrial carcinoma, which revealed that TUSC7 might be involved in tumorigenesis and progression of endometrial carcinoma...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28648665/mir-491-inhibits-osteosarcoma-lung-metastasis-and-chemoresistance-by-targeting-%C3%AE-b-crystallin
#16
Shu-Nan Wang, Song Luo, Chang Liu, Zhenghao Piao, Wenlong Gou, Yun Wang, Wei Guan, Qing Li, Hua Zou, Zhen-Zhou Yang, Dong Wang, Yan Wang, Meng Xu, Hua Jin, Cheng-Xiong Xu
Dysregulated microRNAs (miRNAs) play an important role in osteosarcoma (OS) progression. In the present study, we investigate the clinical significance of serum miR-491 level and the potential role of miR-491 in OS lung metastasis and chemoresistance. Clinical data show that the level of miR-491 was decreased in serum from OS patients compared with healthy control subjects, and that a decreased serum miR-491 level is correlated with increased metastasis, poor chemoresponse, and lower survival rate in OS patients...
June 22, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28648300/the-effects-of-2-3-dimercapto-1-propanesulfonic-acid-dmps-and-meso-2-3-dimercaptosuccinic-acid-dmsa-on-the-nephrotoxicity-in-the-mouse-during-repeated-cisplatin-cddp-treatments
#17
Y Yajima, M Kawaguchi, M Yoshikawa, M Okubo, E Tsukagoshi, K Sato, A Katakura
Previously, we reported that specific lower dose of sodium 2,3-dimercapto-1-propanesulfonic acid (DMPS) which is an antidote to heavy metal intoxication, inversely enhanced cisplatin (CDDP)-induced antitumor activity to S-180 cell-bearing mouse. This activity was only weak with meso-2,3-dimercaptosuccinic acid (DMSA), however. This study investigated the effects of lower doses of DMPS or DMSA on the nephrotoxicity and kinetics of CDDP. Kidney and blood isolated from female mice which received CDDP with or without DMPS or DMSA once daily for 4 days were provided for measuring levels of blood urea nitrogen (BUN) and transporter proteins (OCT2: organic cation transporter; MATE1: multidrug and toxin extrusion) mRNA, and CDDP-originated platinum, and TUNEL staining of renal tubular cells...
June 3, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28628910/the-efficacy-of-trimodal-chemoradiotherapy-with-cisplatin-as-a-bladder-preserving-strategy-for-the-treatment-of-muscle-invasive-bladder-cancer
#18
Kazuhiro Nagao, Takahiko Hara, Jun Nishijima, Kosuke Shimizu, Nakanori Fujii, Keita Kobayashi, Yoshihisa Kawai, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Hideyasu Matsuyama
INTRODUCTION: Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with those obtained by ORC. PATIENTS AND METHODS: We retrospectively analyzed the data of 50 patients with MIBC treated by trimodal chemoradiotherapy with cisplatin (CDDP-radiation [CDDP-R])...
June 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28627624/pro-oxidant-activity-of-sulforaphane-and-cisplatin-potentiates-apoptosis-and-simultaneously-promotes-autophagy-in-malignant-mesothelioma-cells
#19
Yoon-Jin Lee, Sang-Han Lee
Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent. The present study investigated the effects of SFN on enhancing the anticancer role of cisplatin (cis-dichlorodiammineplatinum; CDDP) in H‑28 malignant mesothelioma cells. At concentrations demonstrating limited toxicity in MeT‑5A normal human mesothelial cells, combination treatment with the two compounds exhibited synergistic growth‑inhibiting and apoptosis‑promoting activities, as demonstrated by a series of proapoptotic events, including reactive oxygen species accumulation, loss of mitochondrial membrane potential, upregulation of p53 expression, increased B‑cell lymphoma 2 (Bcl‑2) associated X protein/Bcl‑2 ratio, activation of caspase‑3, the occurrence of a sub‑G0/G1 peak and an increase in cells with pyknotic and fragmented nuclei, Annexin V‑phycoerythrin‑positive staining and G2/M phase‑transition delay in the cell cycle...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627458/sirna-loaded-biodegradable-nanocarriers-for-therapeutic-mapk1-silencing-against-cisplatin-induced-ototoxicity
#20
Ibrahima Youm, Matthew B West, Wei Li, Xiaoping Du, Donald L Ewert, Richard D Kopke
Ototoxicity represents a major adverse side-effect of cis-diamminedichloroplatinum-II (cisplatin, CDDP). The mitogen-activated protein kinase (MAPK) pathway is thought to play a central role in potentiating the apoptotic effect of CDDP within the cochlea. We hypothesized that prophylactic inhibition of MAPK signaling, using small interfering RNA (siRNA), might confer a protective effect against CDDP-induced apoptosis within the auditory sensory epithelia. To enhance the therapeutic utility of this approach, we synthesized biocompatible siMAPK1-loaded nanoparticles (NPs) and performed physicochemical characterizations for size, morphology, drug loading and release kinetics, using dynamic light scattering, electron microscopy and spectrophotometric analyses, respectively...
June 13, 2017: International Journal of Pharmaceutics
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