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https://www.readbyqxmd.com/read/28066612/elevated-hotair-expression-associated-with-cisplatin-resistance-in-non-small-cell-lung-cancer-patients
#1
Ming-Yue Liu, Xi-Qing Li, Tian-Hui Gao, Yao Cui, Ning Ma, Yun Zhou, Guo-Jun Zhang
BACKGROUND: This study investigated the mechanism of drug resistance in non-small cell lung cancer (NSCLC) patients. We specifically studied whether long noncoding RNAs influence drug resistance in NSCLC to discover new therapeutic targets to increase the survival rate of drug-resistant NSCLC patients. METHODS: Tissue samples were collected from NSCLC patients, and total RNA was isolated for assessment of HOTAIR expression and drug resistance status. MTT assays, tumor sphere formation assays, and western blot were performed to cytologically determine the relationship between HOTAIR expression and cisplatin resistance, as well as to elucidate the potential molecular mechanism involved...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28052414/microrna-218-inhibits-tumor-growth-and-increases-chemosensitivity-to-cddp-treatment-by-targeting-bcat1-in-prostate-cancer
#2
Wenjing Zhu, Yiqun Shao, Yu Peng
MicroRNAs have been reported to be associated with chemosensitivity of several types of cancers. However, the underlying molecular mechanisms are poorly understood. In this study, we explored miR-218 increased the chemosensitivity to cis-diaminedichloroplatinum treatment of prostate cancer. We found that the expression level of miR-218 was down-regulated in the human prostate cancer specimens. Moreover, overexpression of miR-218 inhibited cell viability, migration and invasion in PC3 and DU145 cells. Furthermore, we demonstrated that the tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression...
January 4, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28012928/ameliorative-effect-of-parsley-oil-on-cisplatin-induced-hepato-cardiotoxicity-a-biochemical-histopathological-and-immunohistochemical-study
#3
Suhair A Abdellatief, Azza A A Galal, Sameh M Farouk, Mohamed M Abdel-Daim
Cisplatin (cis-diamminedichloroplatinum, CDDP) is an effective DNA alkylating agent used in the treatment of different types of tumors; however, its clinical use is associated with hepato-cardiotoxicity. The current study was designed to assess the potential protective effect of parsley oil (PO) against CDDP-induced hepato-cardiotoxicity. For this purpose, 25 adult male rats were assigned into five groups, each containing five animals. Group I (control) was administered saline solution. Group II was administered PO at a dosage of 0...
December 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28011474/cervical-cancer-patient-derived-orthotopic-xenograft-pdox-is-sensitive-to-cisplatinum-and-resistant-to-nab-paclitaxel
#4
Takashi Murakami, Takuya Murata, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Igarashi, Ho Kyoung Hwang, Yukihiko Hiroshima, Chihiro Hozumi, Shin Komatsu, Takashi Kikuchi, Thinzar M Lwin, Jonathan C Delong, Kentaro Miyake, Yong Zhang, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M Hoffman
BACKGROUND: Cervical cancer is a world-wide problem that requires transformative therapeutic strategies. We have previously developed patient-derived orthotopic xenograft (PDOX) nude-mouse models of this disease. In the present report, we demonstrate that the standard drug, cisplatinum (CDDP), is highly-effective while the new, highly-touted agent, nab-paclitaxel (NAB-PTX) is ineffective. MATERIALS AND METHODS: Cervical PDOX tumors were grown on the cervix of nude mice for 4 weeks after surgical orthotopic implantation (SOI)...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28009925/synthesis-in-vitro-and-in-vivo-evaluation-of-new-hybrids-of-millepachine-and-phenstatin-as-potent-tubulin-polymerization-inhibitors
#5
Baijiao An, Shun Zhang, Jun Yan, Ling Huang, Xingshu Li
In this paper, a series of millepachine derivatives were synthesized and evaluated as tubulin polymerization inhibitors. The optimal compound 5i, (3-hydroxy-4-methoxyphenyl)(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)methanone, displayed the highest cytotoxicity toward a series of cancer cells (ranging from 18 to 45 nM of IC50). Further investigation revealed that 5i significantly repressed the multidrug resistant cells (A549/CDDP, A2780/TAX) and had little cytotoxicity towards human normal cells (HLF, BJ). Cellular mechanism studies demonstrated that 5i induced G2/M phase arrest and apoptosis, which was associated with the collapse of the mitochondrial membrane potential (MMP)...
December 23, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27986347/subgroup-analysis-according-to-human-papillomavirus-status-and-tumor-site-of-a-randomized-phase-ii-trial-comparing-cetuximab-and-cisplatin-combined-with-radiation-therapy-for-locally-advanced-head-and-neck-cancer
#6
Michela Buglione, Marta Maddalo, Renzo Corvò, Luigi Pirtoli, Fabiola Paiar, Luciana Lastrucci, Marco Stefanacci, Liliana Belgioia, Monica Crociani, Stefania Vecchio, Pierluigi Bonomo, Silvia Bertocci, Paolo Borghetti, Nadia Pasinetti, Luca Triggiani, Loredana Costa, Sandro Tonoli, Salvatore Grisanti, Stefano Maria Magrini
PURPOSE: We report a subgroup analysis primarily focused on human papillomavirus (HPV)-related oropharyngeal cancer (OPC) from the Cetuximab Plus Radiotherapy Versus Cisplatin Plus Radiotherapy in Locally Advanced Head and Neck Cancer (CTXMAB+RT; ClinicalTrials.gov identifier NCT01216020) trial comparing radiation therapy with concomitant cisplatin (CDDP) versus concomitant cetuximab (CTX) as first-line treatment of locally advanced head and neck cancer. METHODS AND MATERIALS: The data from all the patients in the CTXMAB+RT trial were reviewed and separately analyzed in 3 groups: p16-positive OPC, p16-negative OPC, and all other cancer sites...
October 20, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27980242/a-novel-analytical-method-of-cisplatin-using-the-high-performance-liquid-chromatography-with-a-naphthylethyl-group-bonded-with-silica-gel-%C3%AF-nap-column
#7
Ryuji Kato, Takaji Sato, Michiko Kanamori, Mizuho Miyake, Ayumi Fujimoto, Kyohei Ogawa, Daiki Kobata, Tomoya Fujikawa, Yukari Wada, Rintaro Mitsuishi, Kodai Takahashi, Hideki Imano, Yoshio Ijiri, Yoshiki Mino, Masahiko Chikuma, Kazuhiko Tanaka, Tetsuya Hayashi
Cisplatin is the most widely used anticancer drug in the world. Mono-chloro and none-chloro complexes of cisplatin may be believed to be the activated compounds. The separation of these compounds using octa decyl silyl column or aminopropylsilyl silica gel column is difficult because of high-reactivity and structural similarity. In this study, cisplatin, hydroxo complexes, and OH-dimer were determined by high-performance liquid chromatography (HPLC) using a naphthylethyl group bonded with silica gel (π NAP) column...
December 14, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27975300/nephroprotective-efficacy-of-ceftriaxone-against-cisplatin-induced-subchronic-renal-fibrosis-in-rats
#8
Mohamed M Abdel-Daim, Yasser S El-Sayed, Mabrouk Abd Eldaim, Abdelazim Ibrahim
Cisplatin, or cis-diamminedichloridoplatinum(II), (CDDP) is a broad-spectrum antineoplastic chemotherapeutic agent with a potent efficacy against several malignancies. Its main clinical antineoplastic therapy-limiting adverse effect is nephrotoxicity, where the developments of effective nephroprotectors are needed. Therefore, the present study aimed to investigate the nephroprotective and antifibrotic potential of ceftriaxone (CTX) against CDDP-induced toxicity. Male Wister rats were treated with saline or CTX (100 or 200 mg kg(-1) bw) an hour before CDDP administration (1 mg kg(-1) bw)...
December 14, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27955638/a-retrospective-paired-study-efficacy-and-toxicity-of-nimotuzumab-versus-cisplatin-concurrent-with-radiotherapy-in-nasopharyngeal-carcinoma
#9
H M Li, P Li, Y J Qian, X Wu, L Xie, F Wang, H Zhang, L Liu
BACKGROUND: To compare efficacy and toxicity of nimotuzumab versus cisplatin (CDDP) concurrent with intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). METHODS: We retrospectively reviewed patients with NPC from September 2008 to November 2013. The synchronous regimens included h-R3/RT (nimotuzumab and radiotherapy) one time per week for 6-8 weeks and CDDP/RT (cisplatin and radiotherapy) every three weeks for 2-3 cycles...
December 13, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27942204/loading-cisplatin-onto-6-mercaptopurine-covalently-modified-msns-a-nanomedicine-strategy-to-improve-the-outcome-of-cisplatin-therapy
#10
Xiaojie Lv, Ming Zhao, Yuiji Wang, Xi Hu, Jianhui Wu, Xueyun Jiang, Shan Li, Chunying Cui, Shiqi Peng
In the treatment of cancer patients, cisplatin (CDDP) exhibits serious cardiac and renal toxicities, while classical combinations related to CDDP are unable to solve these problems and may result in worse prognosis. Alternately, this study covalently conjugated 6-mercaptopurine (6MP) onto the surface of mercapto-modified mesoporous silica nanoparticles (MSNS) to form MSNS-6MP and loaded CDDP into the holes on the surface of MSNS-6MP to form MSNS-6MP/CDDP, a tumor-targeting nano-releasing regime for CDDP and 6MP specifically...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27918099/mir-193b-mediates-cebpd-induced-cisplatin-sensitization-through-targeting-ets1-and-cyclin-d1-in-human-urothelial-carcinoma-cells
#11
Siao-Ren Lin, Hsin-Chih Yeh, Wei-Jan Wang, Hung-Lung Ke, Hui-Hui Lin, Wei-Chi Hsu, Shih-Yi Chao, Tzyh-Chyuan Hour, Wen-Jeng Wu, Yeong-Shiau Pu, A-Mei Huang
Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance. However, the underlying molecular mechanisms of CDDP-regulated CEBPD expression and its relevant roles in CDDP responses remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression in a sequence-specific manner. Abnormal miRNAs expression is associated with tumor progression...
December 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27905409/compound-danshen-dripping-pills-modulate-the-perturbed-energy-metabolism-in-a-rat-model-of-acute-myocardial-ischemia
#12
Jiahua Guo, Yonghong Yong, Jiye Aa, Bei Cao, Runbin Sun, Xiaoyi Yu, Jingqiu Huang, Na Yang, Lulu Yan, Xinxin Li, Jing Cao, Nan Aa, Zhijian Yang, Xiangqing Kong, Liansheng Wang, Xuanxuan Zhu, Xiaohui Ma, Zhixin Guo, Shuiping Zhou, He Sun, Guangji Wang
The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904042/risk-factors-associated-with-cisplatin-induced-nephrotoxicity-in-patients-with-advanced-lung-cancer
#13
Takanori Miyoshi, Nobuhiro Misumi, Mikako Hiraike, Yuki Mihara, Takashi Nishino, Minako Tsuruta, Yosei Kawamata, Yoichi Hiraki, Aki Kozono, Masao Ichiki
Cisplatin (CDDP) combination chemotherapy is widely administered to patients with advanced lung cancer. The dose depends on multiple factors, including whether the tumor is non-small-cell lung cancer (NSCLC) or small-cell lung cancer (SCLC). Although efficacy is limited by cisplatin-induced nephrotoxicity (CIN), little is known about the risk factors for this complication. The aim of this study was to identify the risk factors for CIN in patients with advanced lung cancer, both NSCLC and SCLC. We retrospectively reviewed clinical data for 148 patients who underwent initial chemotherapy including CDDP ≥50 mg/m(2) per patient per day for the first course at Kyushu Medical Center between October 2010 and September 2013...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27900087/doublet-chemotherapy-with-cisplatin-and-pemetrexed-is-associated-with-a-favorable-outcome-in-patients-with-advanced-non-squamous-non-small-cell-lung-cancer-who-are-eligible-for-bevacizumab-and-maintenance-therapy
#14
Kazuhisa Nakashima, Haruyasu Murakami, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Tateaki Naito, Masahiro Endo, Toshiaki Takahashi
The previous AVAPERL trial demonstrated that induction therapy with first-line cisplatin (CDDP), pemetrexed (PEM) and bevacizumab (BEV), followed by continuation maintenance therapy with PEM+BEV, improved the progression-free survival (PFS) and overall survival (OS) compared with BEV alone (median PFS, 10.2 vs. 6.6 months and median OS, 19.8 vs. 15.9 months, respectively) in patients with advanced non-squamous non-small-cell lung cancer (non-Sq NSCLC). However, those findings were based on selected patients who were eligible for BEV and maintenance therapy...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27897082/ameliorative-effect-of-an-oxovanadium-iv-complex-against-oxidative-stress-and-nephrotoxicity-induced-by-cisplatin
#15
Abhishek Basu, Arin Bhattacharjee, Subhadip Hajra, Amalesh Samanta, Sudin Bhattacharya
OBJECTIVE: The present study was designed to investigate the chemoprotective efficacy of an L-cysteine-based oxovanadium (IV) complex, namely, oxovanadium (IV)-L-cysteine methyl ester complex (VC-IV) against cisplatin (CDDP)-induced renal injury in Swiss albino mice. METHODS: CDDP was administered intraperitoneally (5 mg/kg body weight) and VC-IV was administered orally (1 mg/kg body weight) in concomitant and 7 days pre-treatment schedule. RESULTS: CDDP-treated mice showed marked kidney damage and renal failure...
November 29, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27890894/clinical-complete-response-from-chemotherapy-in-an-elderly-patient-with-metastatic-gastric-cancer-a-case-report
#16
Tetsuro Kawagoe, Yuta Maruki, Hiroyuki Nagoya, Yuki Kosugi, Teppei Akimoto, Hiroshi Yamawaki, Yasuhiro Kodaka, Mayumi Shimpuku, Nobue Ueki, Seiji Futagami, Kazumasa Miyake, Katsuhiko Iwakiri
An 81-year-old man was admitted with upper abdominal pain and weight loss. Esophagogastroduodenoscopy revealed a large tumor located from the gastric angle to the body. Histological analysis of a biopsy revealed a moderately differentiated adenocarcinoma. Computed tomography revealed metastases in the liver and lung and the patient was subsequently diagnosed with metastatic advanced gastric cancer. He was treated with chemotherapy using S-1 (80 mg/m(2)) and cisplatin (CDDP) (60 mg/m(2)). Twenty-two months after chemotherapy, the gastric tumor, and the nodules in the liver and lung, had disappeared...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27888498/chitosan-nanolayered-cisplatin-loaded-lipid-nanoparticles-for-enhanced-anticancer-efficacy-in-cervical-cancer
#17
Jing-Yi Wang, Yu Wang, Xia Meng
In this study, cisplatin (CDDP)-loaded chitosan-coated solid lipid nanoparticles (SLN) was successfully formulated to treat HeLa cervical carcinoma. The formulation nanoparticles were nanosized and exhibited a controlled release of drug in physiological conditions. The blank nanoparticles exhibited an excellent biocompatibility profile indicating its suitability for cancer targeting. The incorporation of CDDP in SLN remarkably increased the cancer cell death as evident from the MTT assay. Importantly, CDDP-loaded chitosan-coated SLN (CChSLN) significantly (P < 0...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27885848/conveying-a-newly-designed-hydrophilic-anti-human-thymidylate-synthase-peptide-to-cisplatin-resistant-cancer-cells-are-ph-sensitive-liposomes-more-effective-than-conventional-ones
#18
Francesca Sacchetti, Domenico D'Arca, Filippo Genovese, Salvatore Pacifico, Eleonora Maretti, Miriam Hanuskova, Valentina Iannuccelli, Maria Paola Costi, Eliana Leo
CONTEXT: LR-peptide, a novel hydrophilic peptide synthetized and characterized in previous work, is able to reduce the multi-drug resistance response in cisplatin (cDPP) resistant cancer cells by inhibiting human thymidylate synthase (hTS) overexpressed in several tumors, including ovarian and colon-rectal cancers, but it is unable to enter the cells spontaneously. OBJECTIVE: The aim of this work was to design and characterize liposomal vesicles as drug delivery systems for the LR peptide, evaluating the possible benefits of the pH-responsive feature in improving intracellular delivery...
December 26, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27882231/organic-cation-transporter-6-directly-confers-resistance-to-anticancer-platinum-drugs
#19
Tetsuya Oguri, Eiji Kunii, Satoshi Fukuda, Kazuki Sone, Takehiro Uemura, Osamu Takakuwa, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Akio Niimi
Organic cation transporters (OCTs) of the solute carrier family 22 have a critical role in the cellular uptake of anticancer platinum drugs. Recently, we found that a decreased OCT6 expression is associated with a reduced intracellular uptake of cisplatin (CDDP), and concomitant resistance to CDDP. In the present study, we examined whether OCTs directly confer resistance to another platinum drug, oxaliplatin (L-OHP). To address this, we used parental lung cancer cell lines, PC-14 and SBC3; L-OHP-resistant sublines, PC-14/L-OHP and SBC3/L-OHP; and one CDDP-resistant subline PC-14/CDDP, to examine the relationships between the expression of OCTs and intracellular platinum drug concentration or platinum drug resistance...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27869279/highly-potent-extranuclear-targeted-luminescent-iridium-iii-antitumor-agents-containing-benzimidazole-based-ligands-with-a-handle-for-functionalization
#20
Jyoti Yellol, Sergio A Pérez, Gorakh Yellol, Juraj Zajac, Antonio Donaire, Gloria Vigueras, Vojtech Novohradsky, Christoph Janiak, Viktor Brabec, José Ruiz
A series of 6 substitutionally inert and luminescent iridium(iii) antitumor agents of the type [Ir(C(∧)N)2(N(∧)N)][PF6] containing a benzimidazole N(∧)N ligand with an ester group as a handle for further functionalization has been prepared. They exhibit IC50 values in the high nanomolar range in some ovarian and breast cancer cell lines (approximately 100× more cytotoxic than cisplatin (CDDP) in MDA-MB-231) and are located in the actin cortex predominantly as shown by confocal luminescence microscopy...
December 1, 2016: Chemical Communications: Chem Comm
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