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https://www.readbyqxmd.com/read/29760866/short-genome-report-of-cellulose-producing-commensal-escherichia-coli-1094
#1
Joaquin Bernal-Bayard, Laura Gomez-Valero, Aimee Wessel, Varun Khanna, Christiane Bouchier, Jean-Marc Ghigo
Bacterial surface colonization and biofilm formation often rely on the production of an extracellular polymeric matrix that mediates cell-cell and cell-surface contacts. In Escherichia coli and many Betaproteobacteria and Gammaproteobacteria cellulose is often the main component of the extracellular matrix. Here we report the complete genome sequence of the cellulose producing strain E. coli 1094 and compare it with five other closely related genomes within E. coli phylogenetic group A. We present a comparative analysis of the regions encoding genes responsible for cellulose biosynthesis and discuss the changes that could have led to the loss of this important adaptive advantage in several E...
2018: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29746980/in-silico-analysis-of-schmidtea-mediterranea-tir-domain-containing-proteins
#2
Landry Laure Tsoumtsa, Seynabou Sougoufoura, Cedric Torre, Emmanuel Lemichez, Pierre Pontarotti, Eric Ghigo
While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors...
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29740022/hyperactivity-of-rac1-gtpase-pathway-impairs-neuritogenesis-of-cortical-neurons-by-altering-actin-dynamics
#3
Valentina Zamboni, Maria Armentano, Gaia Berto, Elisa Ciraolo, Alessandra Ghigo, Donatella Garzotto, Alessandro Umbach, Ferdinando DiCunto, Elena Parmigiani, Marina Boido, Alessandro Vercelli, Nadia El-Assawy, Alessandro Mauro, Lorenzo Priano, Luisa Ponzoni, Luca Murru, Maria Passafaro, Emilio Hirsch, Giorgio R Merlo
The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function mutations in RAC1 and other genes of the Rac signaling pathway have been implicated in the pathogenesis of Intellectual Disability (ID). The Rac1 activity is negatively controlled by GAP proteins, however the effect of Rac1 hyperactivity on neuronal networking in vivo has been poorly studied. ArhGAP15 is a Rac-specific negative regulator, expressed in the main subtypes of pyramidal cortical neurons...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29682162/metabolic-alterations-in-a-slow-paced-model-of-pancreatic-cancer-induced-wasting
#4
Elisabeth Wyart, Simone Reano, Myriam Y Hsu, Dario Livio Longo, Mingchuan Li, Emilio Hirsch, Nicoletta Filigheddu, Alessandra Ghigo, Chiara Riganti, Paolo Ettore Porporato
Cancer cachexia is a devastating syndrome occurring in the majority of terminally ill cancer patients. Notably, skeletal muscle atrophy is a consistent feature affecting the quality of life and prognosis. To date, limited therapeutic options are available, and research in the field is hampered by the lack of satisfactory models to study the complexity of wasting in cachexia-inducing tumors, such as pancreatic cancer. Moreover, currently used in vivo models are characterized by an explosive cachexia with a lethal wasting within few days, while pancreatic cancer patients might experience alterations long before the onset of overt wasting...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29676902/evidence-of-an-important-role-of-photochemistry-in-the-attenuation-of-the-secondary-contaminant-3-4-dichloroaniline-in-paddy-water
#5
Luca Carena, Mariagrazia Proto, Marco Minella, Giovanni Ghigo, Cristina Giovannoli, Marcello Brigante, Gilles Mailhot, Valter Maurino, Claudio Minero, Davide Vione
The secondary pollutant 3,4-dichloroaniline (DCA) is produced by the biological degradation of several herbicides, including propanil in paddy fields. The enzymatic hydrolysis of propanil yields DCA with almost quantitative yield. DCA undergoes rather fast photodegradation in paddy water, mostly by direct photolysis. An exception might be represented by the cases (rather rare in paddies) of quite high nitrate concentration (around 50 mgNO3- L-1), when DCA degradation by CO3·- would play a comparable role as the direct photolysis...
April 20, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29675007/mechanistic-and-structural-insights-into-the-unique-tetr-dependent-regulation-of-a-drug-efflux-pump-in-mycobacterium-abscessus
#6
Matthias Richard, Ana Victoria Gutiérrez, Albertus J Viljoen, Eric Ghigo, Mickael Blaise, Laurent Kremer
Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were linked to increased resistance to thiacetazone derivatives. Herein, the DNA-binding activity of MAB_4384 was investigated by electrophoretic mobility shift assays using the palindromic sequence IRS5/L5 located upstream of mmpS5/mmpL5 ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29627527/insight-into-stem-cell-regulation-from-sub-lethally-irradiated-worms
#7
Leonardo Rossi, Lucia Cassella, Paola Iacopetti, Claudio Ghezzani, Luigi Tana, Gregory Gimenez, Eric Ghigo, Alessandra Salvetti
Despite the significant advances in the comprehension of stem cell control network, the nature of extrinsic signals regulating their dynamic remains to be understood. In this paper, we take advantage of the stem cell repopulation process that follows low-dose X-ray treatment in planarians to identify genes, preferentially enriched in differentiated cells, whose expression is activated during the process. Genetic silencing of some of them impaired the stem cell repopulation, suggesting a tight extrinsic control of stem cell activity...
April 5, 2018: Gene
https://www.readbyqxmd.com/read/29599937/a-novel-interpretation-for-arterial-pulse-pressure-amplification-in-health-and-disease
#8
Manuel R Alfonso, Ricardo L Armentano, Leandro J Cymberknop, Arthur R Ghigo, Franco M Pessana, Walter E Legnani
Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressure waves as combinations of solitons. This model captures many key features of wave propagation in the systemic network and, in particular, pulse pressure amplification (PPA), which is a mechanical biomarker of cardiovascular risk...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29594066/a-simple-and-rapid-gene-disruption-strategy-in-mycobacterium-abscessus-on-the-design-and-application-of-glycopeptidolipid-mutants
#9
Albertus Viljoen, Ana Victoria Gutiérrez, Christian Dupont, Eric Ghigo, Laurent Kremer
Little is known about the disease-causing genetic determinants that are used by Mycobacterium abscessus , increasingly acknowledged as an important emerging pathogen, notably in cystic fibrosis. The presence or absence of surface exposed glycopeptidolipids (GPL) conditions the smooth (S) or rough (R) M. abscessus subsp. abscessus ( M. abscessus ) variants, respectively, which are characterized by distinct infective programs. However, only a handful of successful gene knock-out and conditional mutants have been reported in M...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29563880/antineoplastic-drug-induced-cardiotoxicity-a-redox-perspective
#10
REVIEW
Gilda Varricchi, Pietro Ameri, Christian Cadeddu, Alessandra Ghigo, Rosalinda Madonna, Giancarlo Marone, Valentina Mercurio, Ines Monte, Giuseppina Novo, Paolo Parrella, Flora Pirozzi, Antonio Pecoraro, Paolo Spallarossa, Concetta Zito, Giuseppe Mercuro, Pasquale Pagliaro, Carlo G Tocchetti
Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. Cellular sources of ROS/RNS are cardiomyocytes, endothelial cells, stromal and inflammatory cells in the heart. Mitochondria, peroxisomes and other subcellular components are central hubs that control redox homeostasis...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29557740/pi3k-signaling-in-chronic-obstructive-pulmonary-disease-mechanisms-targets-and-therapy
#11
Flora Pirozzi, Kai Ren, Alessandra Murabito, Alessandra Ghigo
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by irreversible chronic inflammation and airflow obstruction. It affects more than 64 million patients worldwide and it is predicted to become the third cause of death in the industrialized world by 2030. Current available therapies are not able to block disease progression and to reduce mortality, underlying the need of a better understanding of COPD pathophysiological mechanisms to identify new molecular therapeutic targets...
March 20, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29549338/asymmetric-adhesion-of-rod-shaped-bacteria-controls-microcolony-morphogenesis
#12
Marie-Cécilia Duvernoy, Thierry Mora, Maxime Ardré, Vincent Croquette, David Bensimon, Catherine Quilliet, Jean-Marc Ghigo, Martial Balland, Christophe Beloin, Sigolène Lecuyer, Nicolas Desprat
Surface colonization underpins microbial ecology on terrestrial environments. Although factors that mediate bacteria-substrate adhesion have been extensively studied, their spatiotemporal dynamics during the establishment of microcolonies remains largely unexplored. Here, we use laser ablation and force microscopy to monitor single-cell adhesion during the course of microcolony formation. We find that adhesion forces of the rod-shaped bacteria Escherichia coli and Pseudomonas aeruginosa are polar. This asymmetry induces mechanical tension, and drives daughter cell rearrangements, which eventually determine the shape of the microcolonies...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29487281/tailed-giant-tupanvirus-possesses-the-most-complete-translational-apparatus-of-the-known-virosphere
#13
Jônatas Abrahão, Lorena Silva, Ludmila Santos Silva, Jacques Yaacoub Bou Khalil, Rodrigo Rodrigues, Thalita Arantes, Felipe Assis, Paulo Boratto, Miguel Andrade, Erna Geessien Kroon, Bergmann Ribeiro, Ivan Bergier, Herve Seligmann, Eric Ghigo, Philippe Colson, Anthony Levasseur, Guido Kroemer, Didier Raoult, Bernard La Scola
Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification...
February 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29476488/imaging-the-lymph-node-stroma
#14
Clément Ghigo, Rebecca Gentek, Marc Bajénoff
Lymph node (LN) stromal cells are being recognized as key organizers of the immune system. They assemble in complex 3D networks and hence, need to be studied in situ to fully understand their exact functions. Here, we describe two distinct but complementary procedures that allow analyzing LN stromal cells at high resolution by confocal imaging.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29422051/a-systematic-literature-review-of-reviews-on-techniques-for-physical-activity-measurement-in-adults-a-dedipac-study
#15
REVIEW
Kieran P Dowd, Robert Szeklicki, Marco Alessandro Minetto, Marie H Murphy, Angela Polito, Ezio Ghigo, Hidde van der Ploeg, Ulf Ekelund, Janusz Maciaszek, Rafal Stemplewski, Maciej Tomczak, Alan E Donnelly
The links between increased participation in Physical Activity (PA) and improvements in health are well established. As this body of evidence has grown, so too has the search for measures of PA with high levels of methodological effectiveness (i.e. validity, reliability and responsiveness to change). The aim of this "review of reviews" was to provide a comprehensive overview of the methodological effectiveness of currently employed measures of PA, to aid researchers in their selection of an appropriate tool...
February 8, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29366177/non-catalytic-function-of-pi3kg-on-smooth-muscle-cells-proliferation-a-novel-therapeutic-strategy-to-prevent-arterial-remodeling-through-camp-modulation
#16
Adrien Lupieri, Alessandra Ghigo, Regis Blaise, Natalia Smirnova, Nicole Malet, Pierre Vincent, Stephanie Gayral, Emilio Hirsch, Muriel Laffargue
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29348263/phosphoinositide-3-kinase-gamma-inhibition-protects-from-anthracycline-cardiotoxicity-and-reduces-tumor-growth
#17
Mingchuan Li, Valentina Sala, Maria Chiara De Santis, James Cimino, Paola Cappello, Nicola Pianca, Anna Di Bona, Jean Piero Margaria, Miriam Martini, Edoardo Lazzarini, Flora Pirozzi, Luca Rossi, Irene Franco, Julia Bornbaum, Jacqueline Heger, Susanne Rohrbach, Alessia Perino, Carlo G Tocchetti, Braulio H F Lima, Mauro M Teixeira, Paolo E Porporato, Rainer Schulz, Annalisa Angelini, Marco Sandri, Pietro Ameri, Sebastiano Sciarretta, Roberto César P Lima-Júnior, Marco Mongillo, Tania Zaglia, Fulvio Morello, Francesco Novelli, Emilio Hirsch, Alessandra Ghigo
Background -Anthracyclines, such as doxorubicin (DOX), are potent anti-cancer agents for the treatment of solid tumors and hematological malignancies. However, their clinical use is hampered by cardiotoxicity. This study sought to investigate the role of PI3Kγ in DOX-induced cardiotoxicity and the potential cardio-protective and anti-cancer effects of PI3Kγ inhibition. Methods -Mice expressing a kinase-inactive PI3Kγ or receiving PI3Kγ selective inhibitors were subjected to chronic DOX treatment. Cardiac function was analyzed by echocardiography and DOX-mediated signaling was assessed in whole hearts or in isolated cardiomyocytes...
January 18, 2018: Circulation
https://www.readbyqxmd.com/read/29285678/correction-to-pegvisomant-in-acromegaly-an-update
#18
A Giustina, G Arnaldi, F Bogazzi, S Cannavò, A Colao, L De Marinis, E De Menis, E Degli Uberti, F Giorgino, S Grottoli, A G Lania, P Maffei, R Pivonello, E Ghigo
Unfortunately, in page 584, second column, the first sentence under the heading "Type of switch" has been published incorrectly. The complete correct sentence is given below.
February 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29277228/molecular-mechanism-of-action-of-pelargonidin-3-o-glucoside-the-main-anthocyanin-responsible-for-the-anti-inflammatory-effect-of-strawberry-fruits
#19
Larissa Jeremias Duarte, Vitor Clasen Chaves, Marcus Vinicius Pereira Dos Santos Nascimento, Eunice Calvete, Mingchuan Li, Elisa Ciraolo, Alessandra Ghigo, Emilio Hirsch, Claudia Maria Oliveira Simões, Flávio Henrique Reginatto, Eduardo M Dalmarco
Fragaria x ananassa Duch., popularly called strawberry, is known for its worldwide consumption and important biological activities, and these effects are related to its high concentration of anthocyanins. Pelargonidin-3-O-glucoside (P3G) is a major anthocyanin found in strawberry, and was evaluated for its anti-inflammatory action in experimental models. The effect of strawberry extract and P3G, on leukocyte migration, exudation levels and many inflammatory mediators, was therefore evaluated in an in vivo model...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29234007/insights-into-the-structure-and-assembly-of-a-bacterial-cellulose-secretion-system
#20
Petya Violinova Krasteva, Joaquin Bernal-Bayard, Laetitia Travier, Fernando Ariel Martin, Pierre-Alexandre Kaminski, Gouzel Karimova, Rémi Fronzes, Jean-Marc Ghigo
Secreted exopolysaccharides present important determinants for bacterial biofilm formation, survival, and virulence. Cellulose secretion typically requires the concerted action of a c-di-GMP-responsive inner membrane synthase (BcsA), an accessory membrane-anchored protein (BcsB), and several additional Bcs components. Although the BcsAB catalytic duo has been studied in great detail, its interplay with co-expressed subunits remains enigmatic. Here we show that E. coli Bcs proteins partake in a complex protein interaction network...
December 12, 2017: Nature Communications
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