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mechanism of methicilin resistance in staphylococcus aureus

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https://www.readbyqxmd.com/read/25310547/-ventilator-associated-pneumonia-confection-of-a-strategy-of-prophylaxis-and-management-based-on-the-analysis-of-epidemiology
#1
Edgard do Carmo Neto, Paulo César de Souza, Frederico Azevedo, Marcelo Elisio Lugarinho
BACKGROUND AND OBJECTIVES: Variable magnitude of impact on the outcomes of the critically ill patients has been credited to ventilation-associated pneumonia, in terms of mortality, length of hospital stay and mechanic ventilation days. Three objectives have been defined in this study: mortality and incidence of ventilation-associated pneumonia before and after the implantation of a prophylaxis protocol (primary objectives); microbiologic mapping (secondary objective) as an instrument to optimize therapy...
December 2006: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/22129432/computational-studies-of-bacterial-resistance-to-%C3%AE-lactam-antibiotics-mechanism-of-covalent-inhibition-of-the-penicillin-binding-protein-2a-pbp2a
#2
Nguyen Hoa My, Hajime Hirao, Dang Ung Van, Keiji Morokuma
β-Lactam resistance of methicillin-resistant Staphylococcus aureus (MRSA), a pathogenic bacterium that causes staph infections, represents a serious threat to public health. This arises primarily due to the inability of β-lactam antibiotics to inhibit the transpeptidase activity of penicillin-binding protein 2a (PBP2a). Effective inhibition of PBP2a to prevent the bacterial cell wall biosynthesis is of great importance for the treatment of a variety of clinically challenging infectious diseases caused by MRSA...
December 27, 2011: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/21660655/papain-like-proteases-of-staphylococcus-aureus
#3
REVIEW
Tomasz Kantyka, Lindsey N Shaw, Jan Potempa
Staphylococcus aureus remains one of the major humanpathogens, causing a number of diverse infections. the growing antibiotic resistance, including vancomycin and methicilin-resistant strains raises the special interest in virulence mechanism of this pathogen. among a number of extracellular virulence factors, S. aureus secretes several proteases of three catalytic classes-metallo, serine and papain-like cysteine proteases. the expression of proteolytic enzymes is strictly controlled by global regulators of virulence factors expression agr and sar and proteases take a role in a phenotype change in postlogarithmic phase of growth...
2011: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/20011685/staphylococcus-aureus-as-an-infectious-agent-overview-of-biochemistry-and-molecular-genetics-of-its-pathogenicity
#4
REVIEW
Konrad Plata, Adriana E Rosato, Grzegorz Wegrzyn
Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S...
2009: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/17073522/telavancin-td-6424-td-6424
#5
REVIEW
(no author information available yet)
Telavancin [TD-6424, ARBELIC] is an injectable, bactericidal lipoglycopeptide antibacterial that is in clinical development with Theravance (formerly Advanced Medicine) in the US. Telavancin, which was discovered by Theravance through the application of multivalent drug design, has a broad spectrum of activity against Gram-positive pathogens. Telavancin is currently in phase III development for complicated skin and soft tissue infections (including those caused by methicilin-resistant Staphylococcus aureus [MRSA]), nosocomial pneumonia, as well as other Gram-positive pathogens...
2006: Drugs in R&D
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