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https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#1
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29776596/surgical-procedures-in-health-professional-shortage-areas-impact-of-a-surgical-incentive-payment-plan
#2
Adrian Diaz, Katiuscha Merath, Fabio Bagante, Qinyu Chen, Ozgur Akgul, Eliza Beal, Jay Idrees, Griffin Olsen, Faiz Gani, Timothy M Pawlik
INTRODUCTION: The Affordable Care Act established a Center for Medicare/Medicaid Services based 10% reimbursement bonus for general surgeons in Health Professional Shortage Areas. We sought to assess the impact of the Affordable Care Act Surgery Incentive Payment on surgical procedures performed in Health Professional Shortage Areas. METHODS: Hospital utilization data from the California Office of Statewide Health Planning and Development between January 1, 2006, and December 31, 2015, were used to categorize hospitals according to Health Professional Shortage Area location...
May 15, 2018: Surgery
https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#3
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29773856/hyperbaric-oxygen-can-induce-angiogenesis-and-recover-erectile-function
#4
Amir Hadanny, Erez Lang, Laurian Copel, Oshra Meir, Yair Bechor, Gregory Fishlev, Jacob Bergan, Amnon Zisman, Shai Efrati
Erectile dysfunction (ED) is caused by microvascular or macrovascular insufficiency in the majority of patients. Recent studies have shown that hyperbaric oxygen therapy (HBOT) can induce angiogenesis in different body organs. The effect of HBOT on the non-surgery-related ED has not been investigated yet. The aim of the current study was to evaluate the effects of HBOT on sexual function and penile vascular bed in non-surgical ED patients. A prospective analysis of patients suffering from chronic ED treated with 40 daily HBOT sessions...
May 18, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29773646/a-blood-capillary-plexus-derived-population-of-progenitor-cells-contributes-to-genesis-of-the-dermal-lymphatic-vasculature-during-embryonic-development
#5
Cathy Pichol-Thievend, Kelly L Betterman, Xiaolei Liu, Wanshu Ma, Renae Skoczylas, Emmanuelle Lesieur, Frank L Bos, Dorte Schulte, Stefan Schulte-Merker, Benjamin M Hogan, Guillermo Oliver, Natasha L Harvey, Mathias Francois
Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood capillary plexus constitutes an additional, local source of LECs that contributes to the formation of the dermal lymphatic vascular network. We describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1 -dependent manner to establish discrete LEC clusters...
May 17, 2018: Development
https://www.readbyqxmd.com/read/29773414/hypofractionated-whole-breast-irradiation-with-or-without-boost-in-elderly-patients-clinical-evaluation-of-an-italian-experience
#6
Maria Carmen De Santis, Francesca Bonfantini, Francesca Di Salvo, Alba Fiorentino, Michela Dispinzieri, Mariangela Caputo, Serena Di Cosimo, Gabriella Mariani, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Laura Lozza
PURPOSE: To examine local control, disease-free survival (DFS), and toxicity in elderly (≥ 65 years) breast cancer patients treated with hypofractionated radiotherapy (hypo-RT) with or without a boost to the tumor bed. PATIENTS AND METHODS: The study was conducted on 752 patients treated from April 2009 to February 2017. Patients received 42.4 Gy in 16 daily fractions (2.65 Gy per fraction). A boost was only administered in cases of grade 3 primary tumor and close or positive margins...
April 22, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29768616/associating-socioeconomic-position-and-maternal-depression-with-the-health-of-children-an-evaluation-of-the-2008-brazilian-household-survey
#7
Pedro Henrique Soares Leivas, Cesar Augusto Oviedo Tejada, Andréa Dâmaso Bertoldi, Anderson Moreira Aristides Dos Santos, Paulo de Andrade Jacinto
The study analyzed the association between socioeconomic position (income), maternal depression and the health of children in Brazil, using information from the 2008 National Household Survey (PNAD/IBGE). The analysis considered the sampling design for the research and included 46,874 individuals up to the age of nine. The Poisson models were estimated for three health outcomes for children: health as reported by the parents or the responsible person, restrictions on habitual activities for health reasons and periods when they were confined to bed two weeks before the interviews in the study...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29765343/questionnaire-based-maladaptive-decision-coping-patterns-involved-in-binge-eating-among-1013-college-students
#8
Wan-Sen Yan, Ran-Ran Zhang, Yan Lan, Zhi-Ming Li, Yong-Hui Li
Binge Eating Disorder (BED), considered a public health problem because of its impact on psychiatric, physical, and social functioning, merits much attention given its elevation to an independent diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Similar with substance use disorders, some neuropsychological and personality constructs are potentially implicated in the onset and development of BED, in which poor decision-making has been suggested to facilitate overeating and BED...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29761543/influence-of-backrest-angle-on-swallowing-musculature-activity-and-physical-strain-during-the-head-lift-exercise-in-elderly-women-compared-with-young-women
#9
Naomi Koshi, Hiromi Matsumoto, Tetsuya Hiramatsu, Yoko Shimizu, Hiroshi Hagino
BACKGROUND: The head lift exercise (HLE) is the most common exercise for strengthening the swallowing musculature in clinical situations. OBJECTIVE: The present study investigated whether a change in the backrest angle of a bed influences swallowing musculature activity and physical strain during the HLE and whether it can generate an appropriate exercise load for swallowing musculature activity for older women compared with younger women. METHODS: Participants were 10 elderly women and 10 young women, each of whom performed the HLE with a backrest randomly angled at 0°, 15°, 30°, or 45°...
May 14, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29760276/early-blood-brain-barrier-disruption-in-ischemic-stroke-initiates-multifocally-around-capillaries-venules
#10
Angelika Hoffmann, Tassilo Dege, Reiner Kunze, Anne-Sophie Ernst, Holger Lorenz, Laura-Inés Böhler, Thomas Korff, Hugo H Marti, Sabine Heiland, Martin Bendszus, Xavier Helluy, Mirko Pham
BACKGROUND AND PURPOSE: Detection and localization of the early phase of blood-brain barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major challenge but may be a relevant outcome parameter in stroke. METHODS: We studied early BBBD in mice after transient middle cerebral artery occlusion by multimodal, high-field (9.4T) in vivo magnetic resonance imaging, including the contrast agent gadofluorineM as an albumin-binding tracer...
May 14, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29759641/impact-of-antimicrobial-wipes-compared-with-hypochlorite-solution-on-environmental-surface-contamination-in-a-health-care-setting-a-double-crossover-study
#11
Harsha Siani, Rebecca Wesgate, Jean-Yves Maillard
OBJECTIVE: Antimicrobial wipes are increasingly used in health care settings. This study evaluates, in a clinical setting, the efficacy of sporicidal wipes versus a cloth soaked in a 1,000 ppm chlorine solution. INTERVENTION: A double-crossover study was performed on 2 different surgical and cardiovascular wards in a 1,000-bed teaching hospital over 29 weeks. The intervention period that consisted of surface decontamination with the preimpregnated wipe or cloth soaked in chlorine followed a 5-week baseline assessment of microbial bioburden on surfaces...
May 11, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29758401/factors-determining-the-exposure-of-dairy-farmers-to-thoracic-organic-dust
#12
Hugo Pfister, Laurent Madec, Pierre Le Cann, Nathalie Costet, Martine Chouvet, Stéphane Jouneau, Laurent Vernhet
Bronchial respiratory diseases are more common in dairy farmers than in the general population, perhaps because the repeated inhalation of organic dust contributes to the development of these disorders. However, the factors determining the exposure of farmers to particles that can enter the lower bronchial tract and interact with it, i.e. the thoracic fraction of the inhalable dust, remain to be identified. We therefore measured the exposure of dairy farmers to thoracic organic dust and identified the farm features and tasks that increased exposure...
May 11, 2018: Environmental Research
https://www.readbyqxmd.com/read/29756097/evaluation-of-stressors-in-intensive-care-units
#13
Yücel Gültekin, Zerrin Özçelik, Seda Banu Akıncı, Halil Kaya Yorgancı
Objective: Physical and psychological stressors adversely affect the treatment and length of stay of patients in intensive care units. In this study, we aimed to describe environmental and psychological stressors affecting intensive care unit patients and to determine their priorities. Material and Methods: In this study, the 40-item Intensive Care Unit Environmental Stressor Scale was administered to patients in the General Surgery Intensive Care Unit and the Anesthesiology and Reanimation Intensive Care Unit...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29753957/brainstem-blood-brain-barrier-disruption-using-focused-ultrasound-a-demonstration-of-feasibility-and-enhanced-doxorubicin-delivery
#14
Saira Alli, Carlyn A Figueiredo, Brian Golbourn, Nesrin Sabha, Megan Yijun Wu, Andrew Bondoc, Amanda Luck, Daniel Coluccia, Colin Maslink, Christian Smith, Heiko Wurdak, Kullervo Hynynen, Meaghan O'Reilly, James T Rutka
Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve transient BBB opening without tissue injury. Delivery of a targeted ultrasonic wave causes an interaction between administered microbubbles and the capillary bed resulting in enhanced vessel permeability. The use of MRgFUS in the brainstem has not previously been shown but could provide value in the treatment of tumours such as Diffuse Intrinsic Pontine Glioma (DIPG) where the intact BBB has contributed to the limited success of chemotherapy...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29753452/exploring-the-acceptability-of-using-low-friction-bedding-for-patients-with-burns-qualitative-results-from-the-silkie-study
#15
K Whale, J C Ingram, S George, F Spickett-Jones, A Sack, A E Young
BACKGROUND: Skin grafts following deep burns are needed to ensure healing. Grafts that fail and require re-grafting cause significant distress to patients and additional costs for the NHS. Shearing, which leads to graft loss, may be reduced through the use of low-friction bedding. A feasibility study was conducted to assess proof of concept for the use of low-friction bedding for patients with burns. Patient, parent and staff views on the acceptability of this material were explored through semi-structured interviews...
May 9, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29752979/in-line-agglomeration-degree-estimation-in-fluidized-bed-pellet-coating-processes-using-visual-imaging
#16
Andraž Mehle, Domen Kitak, Gregor Podrekar, Boštjan Likar, Dejan Tomaževič
Agglomeration of pellets in fluidized bed coating processes is an undesirable phenomenon that affects the yield and quality of the product. In scope of PAT guidance, we present a system that utilizes visual imaging for in-line monitoring of the agglomeration degree. Seven pilot-scale Wurster coating processes were executed under various process conditions, providing a wide spectrum of process outcomes. Images of pellets were acquired during the coating processes in a contactless manner through an observation window of the coating apparatus...
May 9, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29744794/evaluation-of-risk-factors-for-vancomycin-induced-nephrotoxicity
#17
So Jin Park, Na Ri Lim, Hyo Jung Park, Jae Wook Yang, Min-Ji Kim, Kyunga Kim, Yong Won In, Young Mee Lee
Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN...
May 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29743062/-we-don-t-want-our-clothes-to-smell-smoke-changing-malaria-control-practices-and-opportunities-for-integrated-community-based-management-in-baringo-kenya
#18
Jacinter A Amadi, Daniel O Olago, George O Ong'amo, Silas O Oriaso, Isaac K Nyamongo, Benson B A Estambale
BACKGROUND: The decline in global malaria cases is attributed to intensified utilization of primary vector control interventions and artemisinin-based combination therapies (ACTs). These strategies are inadequate in many rural areas, thus adopting locally appropriate integrated malaria control strategies is imperative in these heterogeneous settings. This study aimed at investigating trends and local knowledge on malaria and to develop a framework for malaria control for communities in Baringo, Kenya...
May 9, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29742219/assessment-of-delirium-using-the-pre-deliric-model-in-an-intensive-care-unit-in-argentina
#19
Fernando Ariel Sosa, Javier Roberti, Margarita Tovar Franco, María Mercedes Kleinert, Agustina Risso Patrón, Javier Osatnik
OBJECTIVE: To describe the incidence of and risk factors for delirium in the intensive care unit of a tertiary care teaching hospital in Argentina and to conduct the first non-European study exploring the performance of the PREdiction of DELIRium in ICu patients (PRE-DELIRIC) model. METHODS: Prospective observational study in a 20-bed intensive care unit of a tertiary care teaching hospital in Buenos Aires, Argentina. The PRE-DELIRIC model was applied to 178 consecutive patients within 24 hours of admission to the intensive care unit; delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29740971/target-position-reproducibility-in-left-breast-irradiation-with-deep-inspiration-breath-hold-using-multiple-optical-surface-control-points
#20
Aurora Fassi, Giovanni B Ivaldi, Paola Tabarelli de Fatis, Marco Liotta, Ilaria Meaglia, Patrizia Porcu, Lea Regolo, Marco Riboldi, Guido Baroni
The aim of this study was to investigate the use of 3D optical localization of multiple surface control points for deep inspiration breath-hold (DIBH) guidance in left-breast radiotherapy treatments. Ten left-breast cancer patients underwent whole-breast DIBH radiotherapy controlled by the Real-time Position Management (RPM) system. The reproducibility of the tumor bed (i.e., target) was assessed by the position of implanted clips, acquired through in-room kV imaging. Six to eight passive fiducials were positioned on the patients' thoraco-abdominal surface and localized intrafractionally by means of an infrared 3D optical tracking system...
May 8, 2018: Journal of Applied Clinical Medical Physics
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