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tincture opium

Mohammadali Nikoo, Nooshin Nikoo, Sanam Javid, Afshar Amiri, Marc Vogel, Fiona Choi, Amir Ali Sepehry, Amir Hooshang Bagheri Valoojerdi, Kerry Jang, Christian Schütz, Shahin Akhondzadeh, Michael Krausz
BACKGROUND AND AIMS: Recently, there has been a growing interest in using Opium Tincture (OT) for treating opioid dependence in certain regions. We aimed to assess the evidence on its safety and efficacy for this indication. METHODS: We searched several databases (CENTRAL, Medline, EMBASE, Web of Science, PsychINFO, ProQuest Dissertation & Theses Database, Iran Medex,, and with no language or publication date limitations. Two reviewers selected Randomized Controlled Trials (RCT), cohort /case-control/ cross-sectional studies and case-series on safety or efficacy of OT for treating opioid dependence and then extracted reported measures of mentioned outcomes from selected studies...
October 14, 2016: Addiction
Tao Liu, Tamorah Lewis, Estelle Gauda, Jogarao Gobburu, Vijay Ivaturi
Conducting and analyzing clinical trials in vulnerable neonates are extremely challenging. The aim of this analysis is to develop a morphine population pharmacokinetics (PK) model using data collected during a randomized control trial in neonates with abstinence syndrome (NAS). A 3-compartment morphine structural PK model after intravenous (IV) administration from previously published work was utilized as prior, whereas an allometric scaling method with physiological consideration was used to extrapolate a PK profile from adults to pediatrics...
August 2016: Journal of Clinical Pharmacology
Farzaneh Tabassomi, Mehran Zarghami, Mohammad-Reza Shiran, Samaneh Farnia, Mohsen Davoodi
The aim of this study was to evaluate the effectiveness of opium tincture versus methadone syrup in the management of acute withdrawal syndrome in opium dependent patients during the detoxification period. In this double-blind randomized controlled study, a total of 74 adult male raw opium dependent patients were treated with opium tincture or methadone syrup 2 times daily for 5 consecutive days. Detoxification was initiated by tapered dose reductions to reach abstinence. At the end of the 10th day, the medications were discontinued...
2016: Journal of Addictive Diseases
Tuan Trang, Ream Al-Hasani, Daniela Salvemini, Michael W Salter, Howard Gutstein, Catherine M Cahill
UNLABELLED: Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as opioid analgesics. Revered for their potent pain-relieving effects, even Morpheus the god of dreams could not have dreamt that his opium tincture would be both a gift and a burden to humankind...
October 14, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Ramona Dadu, Mimi I Hu, Charles Cleeland, Naifa L Busaidy, Mouhammed Habra, Steven G Waguespack, Steven I Sherman, Anita Ying, Patricia Fox, Maria E Cabanillas
INTRODUCTION: Medullary thyroid cancer (MTC)-related diarrhea can be debilitating, reduces quality of life (QOL), and may be the only indication for initiating systemic therapy. Conventional antidiarrheal drugs are not always helpful and may have side effects. Calcium aluminosilicate antidiarrheal (CASAD), a natural calcium montmorrilonite clay, safely adsorbs toxins and inflammatory proteins associated with diarrhea. It was hypothesized that CASAD would reduce the severity of diarrhea and improve QOL in MTC patients...
October 2015: Thyroid: Official Journal of the American Thyroid Association
S Bauchinger, I Sapetschnig, M Danda, C Sommer, B Resch, B Urlesberger, W Raith
BACKGROUND: Neonatal abstinence syndrome (NAS) occurs in neonates whose mothers have taken addictive drugs or were under substitution therapy during pregnancy. Incidence numbers of NAS are on the rise globally, even in Austria NAS is not rare anymore. The aim of our survey was to reveal the status quo of dealing with NAS in Austria. METHODS: A questionnaire was sent to 20 neonatology departments all over Austria, items included questions on scoring, therapy, breast-feeding and follow-up procedures...
August 2015: Zeitschrift Für Geburtshilfe und Neonatologie
Hassan Solhi, Bahman Sadeghi-Sedeh, Pardis Emami, Mohammad Jamalian, Amir Mohammad Kazemifar
BACKGROUND: Tincture of opium (TOP) is currently used for maintenance therapy in treatment of opioids addiction. It contains ethanol. The present study was conducted to assess the increase in blood alcohol concentration (BAC) in its users; a process which may interfere with breath-alcohol test performed by law enforcement or traffic police. METHODS: A total of 143 individuals were selected randomly from drug users who had been referred to an addiction treatment clinic...
July 2014: Addiction & Health
Reza Daneshmand, Zahra Alam Mehrjerdi, Mercede Samiee
BACKGROUND: The current preliminary study aimed to explore the reasons that a group of opiate-dependent patients reported for entry into opium tincture treatment (OTT). METHODS: Through examinations of 52 qualitative focus group interviews with patients from six OTT centers and 10 health providers (in key informant interviews) in Tehran, this study highlights the factors that participants reported as the reasons associated with entry into OTT. Quantitative data including demographic data and details of drug use were analyzed by using SPSS...
August 2014: Iranian Journal of Public Health
Marie Claire Van Hout, Evelyn Hearne
BACKGROUND: Reviews have commented on rising clandestine manufacture of opiate drug solutions for injecting, and to a lesser extent for oral use. Very little is known about user attempts to culture poppy seeds, widely available on the internet for manufacture of long acting medium-high potency oral solutions, both as poppy seed tea or as opium tincture (laudanum). OBJECTIVES: A netnographic research methodology aimed to provide online consumer insight into user sourcing and decision influences, experiences of home manufacture of laudanum, utilization of opium tincture recipes, and consumptive patterns...
April 2015: Substance Use & Misuse
Melissa R Johnson, David R Nash, Mary R Laird, Robert C Kiley, Michael A Martinez
OBJECTIVES: To compare the length of wean and abstinence severity in neonatal and pediatric patients with neonatal abstinence syndrome or iatrogenic opioid dependence treated with a pharmacist-managed, methadone-based protocol compared with physician-managed patients treated with either methadone or dilute tincture of opium (DTO). METHODS: This was a prospective, single-centered, interventional evaluation of 54 pharmacist-managed patients versus 53 retrospective, physician-managed patients...
July 2014: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Anita Siu, Christine A Robinson
The incidence of neonatal abstinence syndrome (NAS) has increased dramatically during the past 15 years, likely due to an increase in antepartum maternal opiate use. Optimal care of these patients is still controversial because of the available published literature lacking sufficient sample size, placebo control, and comparative pharmacologic trials. Primary treatment for NAS consists of opioid replacement therapy with either morphine or methadone. Paregoric and tincture of opium have been abandoned because of relative safety concerns...
July 2014: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Lindsey Law, Jane Rogers, Cathy Eng
Case Study  Mr. D., a 55-year-old male, presented to the medical oncology service with a diagnosis of stage III adenocarcinoma of the sigmoid colon. He presented 7 weeks post sigmoid colectomy with lymph node resection and was initiated on adjuvant chemotherapy with CAPOX (capecitabine [Xeloda] and oxaliplatin [Eloxatin]). Standard dosing was used: oxaliplatin at 130 mg/m(2) on day 1 and capecitabine at approximately 2,000 mg/m(2)/day (rounded to the nearest 500-mg tablet size) for 14 days on and 7 days off (1 cycle = 21 days)...
May 2014: Journal of the Advanced Practitioner in Oncology
Aakriti Mehta, Kathryn Dawn Forbes, Venkata Sasidhar Kuppala
OBJECTIVE: The goal of this study was to assess the current status of neonatal abstinence syndrome management from prenatal counseling to postdischarge follow-up care. METHODS: An anonymous electronic survey of 26 questions was sent to the medical directors or charge nurses at 383 NICUs. Contact information was obtained by using the American Medical Association's FREIDA online database and the 2011 American Hospital Association Guide Book. Responses were gathered by using the SurveyMonkey online portal, which was designed to grant responders 1-time access...
October 2013: Hospital Pediatrics
C Hünseler, M Brückle, B Roth, A Kribs
AIM: To evaluate our treatment of neonatal abstinence syndrome (NAS), our experience with rooming-in of opiate-dependent mothers and to examine the influence of rooming-in on short term outcome of infants exposed to opiates in utero. METHOD: Retrospective analysis of maternal and perinatal data of newborn infants with NAS treated between 2004 and 2011 in a level 3 academic children's hospital in a German metropolis. Therapy of NAS and duration of therapy, length of hospital stay and costs were considered in particular...
September 2013: Klinische Pädiatrie
Zahra Alam Mehrjerdi, Mehran Zarghami
No abstract text is available yet for this article.
April 2013: Hepatitis Monthly
Suzannah Kokotajlo, Christine A Robinson, Amy Presti
OBJECTIVE: To evaluate the difference in time until medical clearance when comparing tincture of opium (TO) to oral morphine (OM) in the treatment of neonatal abstinence syndrome (NAS). DESIGN: Retrospective chart review conducted from May 2007 to July 2011. SETTING: Level III Neonatal Intensive Care unit at Morristown Medical Center in Morristown, New Jersey. PATIENTS, PARTICIPANTS: Clinical Drug Utilization reports identified 26 neonates who were treated with TO and 25 neonates who were treated with OM for NAS...
January 2013: Journal of Opioid Management
Marc-Andre Dugas
No abstract text is available yet for this article.
January 2013: Critical Care Medicine
George S Bause
No abstract text is available yet for this article.
March 2012: Anesthesiology
Alexander Stein, Wieland Voigt, Karin Jordan
Diarrhea is one of the main drawbacks for cancer patients. Possible etiologies could be radiotherapy, chemotherapeutic agents, decreased physical performance, graft versus host disease and infections. Chemotherapy-induced diarrhea (CID) is a common problem, especially in patients with advanced cancer. The incidence of CID has been reported to be as high as 50-80% of treated patients (≥30% CTC grade 3-5), especially with 5-fluorouracil bolus or some combination therapies of irinotecan and fluoropyrimidines (IFL, XELIRI)...
January 2010: Therapeutic Advances in Medical Oncology
Geir W Jacobsen, Erlend Hem, Jóhann A Sigurdsson
At the beginning of the 1800 s neonatal tetanus was a major health hazard on the Westman Islands, an archipelago immediately south of Iceland. Up to 60–70% of newborn babies died in the course of the first two weeks of life, and Danish health authorities were almost helpless in the face of this mysterious disease. In 1847 the young Danish doctor Peter Anton Schleisner (1818-1900) was sent to the islands to investigate the conditions there. He established a maternity hospital, gave advice on hygiene and encouraged breast-feeding and a number of changes in diet...
April 8, 2011: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
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