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Neonatal cerebral thrombosis

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https://www.readbyqxmd.com/read/27823842/cerebral-sinovenous-thrombosis-in-the-asphyxiated-cooled-infants-a-prospective-observational-study
#1
Maurizio Radicioni, Vittorio Bini, Pietro Chiarini, Ambra Fantauzzi, Francesca Leone, Raffaella Scattoni, Pier Giorgio Camerini
BACKGROUND: Cerebral sinovenous thrombosis is unusual in the asphyxiated cooled infants, but reliable data regarding the incidence of this comorbidity are lacking. We assessed the incidence of sinovenous thrombosis in a population of asphyxiated cooled infants by performing routine brain magnetic resonance venography. METHODS: All asphyxiated infants who underwent therapeutic cooling at our institution completed brain magnetic resonance venography after rewarming...
October 6, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27599834/case-report-of-a-central-venous-access-device-associated-thrombosis-with-aortic-embolism-in-a-preterm-infant
#2
Marlene Biermayr, Barbara Brunner, Kathrin Maurer, Rudolf Trawoeger, Ursula Kiechl-Kohlendorfer, Vera Neubauer
BACKGROUND: Thrombosis in neonates is commonly a central venous access device (CVAD) associated complication. Furthermore, a patent foramen ovale (PFO) is frequently seen in preterm infants. Even though a coincidence of both is not unusual, detaching of the thrombus and organisation of an aortic embolism has not been described until now. Treatment recommendations of CVAD-associated thrombosis in neonates do not consider frequently seen complications of preterm infants e.g. intraventricular haemorrhage...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27576316/successful-endovascular-management-of-massive-pansinus-thrombosis-case-report-and-review-of-literature
#3
Alexander Drofa, Evgueni Kouznetsov, Stephen Tomek, Matthew Wiisanen, Michael Manchak, Timothy Lindley, Steven Mitchell, Ferdinand Hui, Dane Breker
Cerebral sinus venous thrombosis (CSVT) is a recognized cause of childhood and neonatal stroke. More than 50% of neonates have a poor outcome, and mortality is high. Coma is a predictor of death in neonatal CSVT. We present the case of a 9-day-old infant, who presented in coma and was treated successfully with a combination of mechanical thrombectomy using the MindFrame System via the right jugular vein, local infusion of recombinant tissue plasminogen activator and abciximab, as well as anticoagulation. In this case, aggressive thrombectomy and thrombolysis achieved complete neurologic restoration safely and quickly...
2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27396366/cerebral-sinovenous-thrombosis-in-neonates-and-children
#4
COMMENT
Melissa G Chung
Investigators from Erasmus University Hospital in Belgium and Gustave-Dron Hospital and Roger-Salengro Hospital in France studied the clinical and neuroradiologic characteristics of cerebral sinovenous thrombosis (CSVT) in neonates and children.
March 2016: Pediatric neurology briefs
https://www.readbyqxmd.com/read/27183555/a-rare-cause-of-retinal-artery-occlusion-in-severe-hypernatremic-dehydration-in-newborns
#5
Pinar Altiaylik Ozer, Emrah Utku Kabatas, Bengi Ece Kurtul, Dilek Dilli, Aysegul Zenciroglu, Nurullah Okumus
Neonatal hypernatremia is an important electrolyte disorder that may have serious complications. It may be a rare and underdiagnosed cause of venous and arterial thrombosis, leading to severe brain damage by cerebral edema and intracranial hemorrhage. Here, the authors present a case of bilateral central retinal artery occlusion in a newborn with severe hypernatremic dehydration who is found to be normal in terms of other causes of retinal arterial thromboembolization. [Ophthalmic Surg Lasers Imaging Retina...
May 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27053184/pediatric-thromboembolism-in-japan
#6
Kenichi Tetsuhara, Akira Ishiguro, Nobuaki Michihata, Sonoko Sensaki, Hisaya Nakadate, Yui Kimura, Daisuke Tomizawa, Kimikazu Matsumoto
OBJECTIVES: To investigate the clinical and epidemiologic characteristics of thromboembolism in Japanese children. METHODS: Clinical data of 77 patients with thromboembolism from a national tertiary pediatric care center were reviewed. RESULTS: Incidence of thromboembolism was calculated to be 15 per 10,000 hospital admissions. Infants younger than one year of age made up the largest age group (25 patients, including nine neonates younger than 30 d)...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27025499/cerebral-sinovenous-thrombosis-csvt-in-children-what-the-pediatric-radiologists-need-to-know
#7
REVIEW
Chiara Carducci, Giovanna Stefania Colafati, Lorenzo Figà-Talamanca, Daniela Longo, Tommaso Lunardi, Francesco Randisi, Bruno Bernardi
Cerebral sinovenous thrombosis (CSVT) is a relatively uncommon and potentially life-threatening condition in childhood, occurring in various clinical settings. Nowadays, however, it is increasingly diagnosed as related to many causes, likely due to greater clinical awareness and improvement of neuroradiologic techniques. The prompt diagnosis is an important goal to significantly reduce the risk of acute complications and long-term sequelae. The purpose of this narrative overview is to provide a useful educational tool in daily clinical practice for radiologists with a broad perspective of CSVT including a discussion of more common potential pitfalls related to misinterpretation of images in children...
May 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27025187/prognostication-value-of-descending-corticospinal-tract-dwi-signal-in-neonatal-cerebral-sinovenous-thrombosis
#8
Matsanga Leyila Kaseka, Mahendranath Moharir, Gabrielle deVeber, Daune MacGregor, Rand Askalan, Nomazulu Dlamini
BACKGROUND: Descending corticospinal tract diffusion-weighted magnetic resonance imaging (MRI) signal is predictive of poor motor outcome in neonatal and childhood arterial ischemic stroke. However, descending corticospinal tract diffusion-weighted MRI signal has not been documented in the setting of cerebral sinovenous thrombosis, and its role is not understood. OBJECTIVE: We describe a neonate with cerebral sinovenous thrombosis, extensive diffusion restriction, and bilateral descending corticospinal tract diffusion-weighted MRI signal on MRI of the brain...
June 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/26970861/radiological-and-clinical-features-of-cerebral-sinovenous-thrombosis-in-newborns-and-older-children
#9
Valentina Lolli, Francesco Molinari, Jean-Pierre Pruvo, Gustavo Soto Ares
BACKGROUND AND PURPOSE: Cerebral sinovenous thrombosis (CSVT) represents an increasingly recognized cause of pediatric stroke. Our purpose was to assess gender and age differences in the etiology, clinical presentation, and imaging features of CSVT in neonates and older children. METHODS: Subjects aged newborn to 18 years diagnosed with CSVT at the Lille university hospital between 2011 and 2014 were included. RESULTS: Eleven neonates and 16 non-neonates constituted the study population...
July 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/26637700/perinatal-thrombosis-implications-for-mothers-and-neonates
#10
REVIEW
Sarah H O'Brien
Stroke is more likely to occur in the perinatal period than any other time in childhood, and these events can lead to a lifetime of intellectual and motor disabilities, epilepsy, and behavioral challenges. This review describes the epidemiology and natural history of perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT), risk factors for these complications, recent evidence regarding treatment strategies, and current gaps in knowledge. Existing evidence demonstrates the multifactorial etiology of symptomatic ischemic stroke in neonates, which includes a combination of maternal, delivery, and neonatal factors...
2015: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/26213552/a-novel-association-between-cerebral-sinovenous-thrombosis-and-nonketotic-hyperglycinemia-in-a-neonate
#11
Sadık Yurttutan, Mehmet Yekta Oncel, Nursel Yurttutan, Halil Degirmencioglu, Nurdan Uras, Ugur Dilmen
Lethargy in newborns usually indicates central nervous system dysfunction, and many conditions such as cerebrovascular events, infections, and metabolic diseases should be considered in the differential diagnosis. Nonketotic hyperglycinemia is an autosomal recessive error of glycine metabolism, characterized by myoclonic jerks, hypotonia, hiccups, apnea, and progressive lethargy that may progress to encephalopathy or even death. Cerebral sinovenous thrombosis is a rare condition with various clinical presentations such as seizures, cerebral edema, lethargy, and encephalopathy...
June 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26207231/sinus-thrombosis-do-animal-models-really-cover-the-clinical-syndrome
#12
REVIEW
Mesut Yenigün, Martin Jünemann, Tibo Gerriets, Erwin Stolz
Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young patients. CVST represents with 0.5-3% of stroke cases a relatively rare disease. CVST affects 3-4 cases per 1 million overall and 7 cases per 1 million children and neonates. Typical clinical symptoms include headache, visual deficits and seizures. Beside the main condition associated with CVST in women in pregnancy and puerperium, the most frequently identified risk factors are oral hormonal contraceptives in combination with coagulation disorders...
June 2015: Annals of Translational Medicine
https://www.readbyqxmd.com/read/25993071/perinatal-ischemic-stroke-a-five-year-retrospective-study-in-a-level-iii-maternity
#13
Virgínia Machado, Sónia Pimentel, Filomena Pinto, José Nona
OBJECTIVE: To study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke. METHODS: Data was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011. RESULTS: There were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis...
January 2015: Einstein
https://www.readbyqxmd.com/read/25761414/paediatric-arterial-ischaemic-stroke-and-cerebral-sinovenous-thrombosis-first-report-from-the-italian-registry-of-pediatric-thrombosis-r-%C3%A2-i-%C3%A2-t-%C3%A2-i-registro-italiano-trombosi-infantili
#14
MULTICENTER STUDY
Agnese Suppiej, Chiara Gentilomo, Paola Saracco, Stefano Sartori, Manuela Agostini, Rossana Bagna, Bianca Bassi, Paola Giordano, Massimo Grassi, Andrea Guzzetta, Donatella Lasagni, Matteo Luciani, Angelo C Molinari, Antonella Palmieri, Maria Caterina Putti, Luca Antonelli Ramenghi, Lidia Luciana Rota, Domenico Sperlì, Anna Maria Laverda, Paolo Simioni
Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral thrombotic events of the R...
June 2015: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/25760834/-long-term-clinical-efficacy-of-mild-hypothermia-therapy-in-neonates-with-hypoxic-ischemic-encephalopathy-a-meta-analysis
#15
Chang-Qing Cao, Yu-Ning Li, Xue-Mei Yang, Yi-Gu Gong, Fang Wang, Wei-Guo Li
OBJECTIVE: To systematically evaluate the long-term clinical efficacy and safety of mild hypothermia therapy in neonates with hypoxic-ischemic encephalopathy (HIE). METHODS: All randomized controlled trials (RCTs) of mild hypothermia therapy for neonatal HIE from inception to March 2014 were retrieved from databases including Cochrane Library, PubMed, Embase, CBMdisc, and Wanfang Data. Meta analysis was performed using RevMan 5.1 Software. RESULTS: Eight RCTs met the search criteria...
February 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25742241/state-of-the-art-cranial-ultrasound-imaging-in-neonates
#16
Ginette M Ecury-Goossen, Fleur A Camfferman, Lara M Leijser, Paul Govaert, Jeroen Dudink
Cranial ultrasound (CUS) is a reputable tool for brain imaging in critically ill neonates. It is safe, relatively cheap and easy to use, even when a patient is unstable. In addition it is radiation-free and allows serial imaging. CUS possibilities have steadily expanded. However, in many neonatal intensive care units, these possibilities are not optimally used. We present a comprehensive approach for neonatal CUS, focusing on optimal settings, different probes, multiple acoustic windows and Doppler techniques...
February 2, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/25650028/-neonatal-seizures-consider-sinus-thrombosis
#17
REVIEW
Janneke Brandhoff, Linda S de Vries, Jaime C Smal
Cerebral sinovenous thrombosis is a possible cause of neonatal seizures. It can be demonstrated by neuroradiological Doppler ultrasound or MRI/MRV. Maternal, perinatal and neonatal factors all contribute to the development of sinovenous thrombosis. It is important to identify these factors and, if necessary and possible, to start treatment. Anticoagulation therapy should be considered when sinovenous thrombosis is diagnosed. Long-term follow-up is needed in these children, as they run a substantial risk of developing postneonatal epilepsy (ESES) and of poorer developmental outcomes...
2015: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/25637006/serial-cranial-ultrasonography-or-early-mri-for-detecting-preterm-brain-injury
#18
Annemarie Plaisier, Marlou M A Raets, Ginette M Ecury-Goossen, Paul Govaert, Monique Feijen-Roon, Irwin K M Reiss, Liesbeth S Smit, Maarten H Lequin, Jeroen Dudink
OBJECTIVE: To investigate detection ability and feasibility of serial cranial ultrasonography (CUS) and early MRI in preterm brain injury. DESIGN: Prospective cohort study. SETTING: Level III neonatal intensive care unit. PATIENTS: 307 infants, born below 29 weeks of gestation. METHODS: Serial CUS and MRI were performed according to standard clinical protocol. In case of instability, MRI was postponed or cancelled...
July 2015: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/25566822/varying-clinical-and-imaging-outcomes-in-patients-with-spontaneous-thrombosis-of-vein-of-galen-malformation-a-report-of-two-cases
#19
Narendra Kumar Jain, Sweta Swaika, Bejoy Thomas, C Kesavadas, T R Kapilamoorthy
BACKGROUND: Vein of Galen malformations are rare congenital intracranial vascular malformations. The pathophysiological consequences usually manifest as high-output cardiac failure and neurological symptoms secondary to cerebral venous congestion and abnormal CSF flow. Management of these patients is complex. Indications and time to intervene are decided depending upon the age of child, clinical presentation, and multisystemic neonatal scores. Many of these children presenting early and who are not in cardiac failure are expectantly followed up...
May 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/25504650/cerebral-sinovenous-thrombosis-in-neonatal-antiphospholipid-syndrome-a-new-entity
#20
REVIEW
M P De Carolis, S Salvi, A Botta, C Cocca, C Garufi, A Lanzone, S De Carolis
Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production of de novo antibodies by the neonate. However, few cases of neonatal APS are reported in the literature, especially regarding arterial thrombotic events. In particular, only two cases of neonatal aPL related isolated cerebral sinovenous thrombosis (CSVT) are described in the literature...
March 2015: Lupus
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