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Neonatal cerebral thrombosis

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https://www.readbyqxmd.com/read/29221746/clinical-and-neuroimaging-characteristics-of-cerebral-sinovenous-thrombosis-in-neonates-undergoing-cardiac-surgery
#1
Nathalie H P Claessens, Selma O Algra, Nicolaas J G Jansen, Floris Groenendaal, Esther de Wit, Alexander A Wilbrink, Felix Haas, Antonius N J Schouten, Rutger A J Nievelstein, Manon J N L Benders, Linda S de Vries
OBJECTIVES: Neonates with congenital heart disease may have an increased risk of cerebral sinovenous thrombosis, but incidence rates are lacking. This study describes the clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. METHODS: Forty neonates (78% male) requiring neonatal univentricular or biventricular cardiac repair using cardiopulmonary bypass were included. All underwent preoperative (median postnatal day 7) and postoperative (median postoperative day 7) magnetic resonance imaging of the brain, including venography, to detect cerebral sinovenous thrombosis...
November 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29168367/neonatal-cerebral-sinovenous-thrombosis-two-cases-two-different-gene-polymorphisms-and-risk-factors
#2
Özden Turan, Deniz Anuk-İnce, Lale Olcay, Taner Sezer, Kaan Gülleroğlu, Zerrin Yılmaz-Çelik, Ayşe Ecevit
Turan Ö, Anuk-İnce D, Olcay L, Sezer T, Gülleroğlu K, Yılmaz-Çelik Z, Ecevit A. Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors. Turk J Pediatr 2017; 59: 71-75. Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/ 5G polymorphism and elevated lipoprotein a...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/28946157/duplex-sonographic-diagnosis-of-perinatal-hemorrhagic-stroke
#3
Karl-Heinz Deeg
Children are particularly at risk for stroke in the neonatal period. Neonatal hemorrhagic stroke is rarer than ischemic stroke. The incidence is 40.7/100 000 live births. Hemorrhagic stroke is caused by a disruption in venous drainage usually due to local thrombosis. As a result of the nonspecific clinical symptoms in this age group, diagnosis is usually made too late. The only relatively specific symptom is a cerebral seizure during the first week of life. Therefore, stroke should be ruled out by diagnostic imaging in the case of any seizure in the first days of life...
October 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28852582/term-neonate-with-atypical-hypoxic-ischemic-encephalopathy-presentation-a-case-report
#4
Nick Townley, Emily McNellis, Venkatesh Sampath
We describe a case of atypical hypoxic-ischemic encephalopathy (HIE) in a neonate following a normal pregnancy and delivery who was found to have an umbilical vein thrombosis. The infant arrived to our center with continuous bicycling movement of her lower extremities. She had a continuous electroencephalogram that showed burst suppression and magnetic resonance imaging of the brain showed diffusely abnormal cerebral cortical/subcortical diffusion restriction which may be secondary hypoxic-ischemic injury. Interestingly, a pathology report noted a focal umbilical vein thrombosis appearing to have compressed an umbilical artery with associated arterial dissection and hematoma...
July 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28828053/ultrasound-prenatal-diagnosis-and-emergency-interventional-radiologic-therapy-of-galen-aneurysmal-malformation-in-a-newborn
#5
Roxana Elena Bohiltea, Natalia Turcan, Cristian Mihalea, Bogdan Dorobat, Eliza Elena Cinteza, Adriana Dan, Magdalena Mihai, Adela Dimitriade, Cristian Boros, Mircea Dumitru, Ionut Gobej, Octavian Munteanu, Monica Mihaela Cirstoiu
Located under the cerebral hemispheres and draining the anterior and central regions of the brain into the sinus of the posterior cerebral fossa, the vein of Galen aneurysmal malformation is considered to be a rare cause of hydrocephaly. The presence of this condition in the neonatal period typically includes intractable heart failure and a poor prognosis. We report a case of aneurysm of the vein of Galen diagnosed prenatally at 28 weeks of gestation, with the delivery at term by caesarean section of a female infant...
December 2016: Mædica
https://www.readbyqxmd.com/read/28798906/cerebral-sinovenous-thrombosis
#6
REVIEW
Rebecca Ichord
Cerebral sinovenous thrombosis (CSVT) is a rare but serious cerebrovascular disorder affecting children from the newborn period through childhood and adolescence. The incidence is estimated at 0.6/100,000/year, with 30-50% occurring in newborns. Causes are diverse and are highly age dependent. Acute systemic illness is the dominant risk factor among newborns. In childhood CSVT, acute infections of the head and neck such as mastoiditis are most common, followed by chronic underlying diseases such as nephrotic syndrome, cancer, and inflammatory bowel disease...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28704875/sonographic-and-doppler-sonographic-diagnosis-of%C3%A2-neonatal-ischemic-stroke
#7
Karl-Heinz Deeg
Children are particularly at risk for stroke in the neonatal period. 1/3 of all strokes in children occur during the perinatal period. The incidence of perinatal stroke is 1:4000. A differentiation is made between ischemic stroke and hemorrhagic stroke. Ischemic strokes are caused by arterial occlusion due to thrombosis or embolism. As a result of the nonspecific clinical symptoms in this age group, diagnosis is usually made too late. The only relatively specific symptom is focal cerebral seizure during the first week of life...
August 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28429607/thalamic-hemorrhagic-stroke-in-the-term-newborn-a-specific-neonatal-syndrome-with-non-uniform-outcome
#8
Laura Merlini, Sylviane Hanquinet, Joel Fluss
BACKGROUND: Neonatal thalamic hemorrhagic stroke is related to cerebral sinus venous thrombosis and associated with neurological sequelae. Predicting factors are however lacking. METHODS: Clinical and radiological findings at onset and on follow-up of 5 neonates with thalamic hemorrhage stroke are described. RESULTS: All neonates presented with abrupt lethargy, ophistotonos, irritability and/or seizures. The thalamic hemorrhagic stroke was most often unilateral (4/5), involving the posterior/entire thalamus in 3 cases and the anterior thalamus in 2...
July 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28330415/novel-detection-of-placental-insufficiency-by-magnetic-resonance-imaging-in-the-nonhuman-primate
#9
Jamie O Lo, Victoria H J Roberts, Matthias C Schabel, Xiaojie Wang, Terry K Morgan, Zheng Liu, Colin Studholme, Christopher D Kroenke, Antonio E Frias
The placenta is a vital organ necessary for healthy fetal development. Placental insufficiency creates an in utero environment where the fetus is at risk of insufficient oxygen or nutrient exchange. This is primarily caused by impairment of either maternal or fetal circulation or vascular thrombosis such as placental infarction. As a result of placental dysfunction, affected fetuses may be growth restricted, neurologically impaired, and at risk of increased morbidity and mortality. In a cohort of 4 pregnant Rhesus macaques, we describe antenatal detection of naturally occurring intrauterine growth restriction (IUGR) and aberrant fetal neurodevelopment in 1 animal...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28262550/pathways-for-neuroimaging-of-neonatal-stroke
#10
REVIEW
Sarah Lee, David M Mirsky, Lauren A Beslow, Catherine Amlie-Lefond, Amy R Danehy, Laura Lehman, Nicholas V Stence, Arastoo Vossough, Max Wintermark, Michael J Rivkin
PURPOSE: To provide consensus-based, suggested imaging protocols to facilitate the accurate and timely diagnosis of a neonate with symptoms concerning for stroke. METHODS: The Writing Group, an international collaboration of pediatric neurologists and neuroradiologists with expertise in perinatal and childhood stroke, participated in a series of pediatric stroke neuroimaging symposia. These discussions, in conjunction with extensive literature review, led to a consensus for imaging protocols to guide practitioners in the diagnosis of neonatal stroke subtypes as defined by the National Institute of Neurological Disorders and Stroke Common Data Elements...
April 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28114647/clinical-characteristics-risk-factors-and-outcomes-associated-with-neonatal-hemorrhagic-stroke-a-population-based-case-control-study
#11
Lauran Cole, Deborah Dewey, Nicole Letourneau, Bonnie J Kaplan, Kathleen Chaput, Clare Gallagher, Jacquie Hodge, Amalia Floer, Adam Kirton
Importance: Hemorrhage into the brain of term newborns often results in major injury and lifelong disability. The clinical epidemiology of neonatal hemorrhagic stroke (NHS) remains undefined, hindering the development of strategies to improve outcomes. Objective: To characterize the incidence, types, presentations, associated factors, and outcomes of neonatal hemorrhagic stroke. Design, Setting, and Participants: Population-based, nested case-control study...
March 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28110589/incidences-risk-factors-and-outcomes-of-neonatal-thromboembolism
#12
Nongnuch Sirachainan, Anchalee Limrungsikul, Ampaiwan Chuansumrit, Pracha Nuntnarumit, Lunliya Thampratankul, Somporn Wangruangsathit, Werasak Sasanakul, Praguywan Kadegasem
BACKGROUND: The incidences of thromboembolism (TE) in neonates were reported to be around 0.51 per 10,000 live births per year for overall TE and 24 per 10,000 NICU admissions per year. As the incidences of TE in children and adults are lower in Asian populations, the incidences, risk factors, and outcomes of neonatal TE may be different to those reports from other countries. OBJECTIVES: To determine the incidences, risk factors, and outcomes of neonatal TE in a tertiary care hospital in Thailand...
February 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28076020/structure-of-the-medullary-veins-of-the-cerebral-hemisphere-and-related-disorders
#13
REVIEW
Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa
Deep medullary veins drain into subependymal veins with four convergence zones and show parallel distribution patterns adjacent to the body or inferior horn and a radial pattern in the frontal horn or trigon of the lateral ventricle. As white matter imaging develops such as diffusion tensor imaging or susceptibility-weighted imaging, requirements for understanding of white matter structures are increasing, not only for understanding of neuronal tracts but also for that of other structures including the fine anatomy of white matter vessels...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27823842/cerebral-sinovenous-thrombosis-in-the-asphyxiated-cooled-infants-a-prospective-observational-study
#14
Maurizio Radicioni, Vittorio Bini, Pietro Chiarini, Ambra Fantauzzi, Francesca Leone, Raffaella Scattoni, Pier Giorgio Camerini
BACKGROUND: Cerebral sinovenous thrombosis is unusual in the asphyxiated cooled infants, but reliable data regarding the incidence of this comorbidity are lacking. We assessed the incidence of sinovenous thrombosis in a population of asphyxiated cooled infants by performing routine brain magnetic resonance venography. METHODS: All asphyxiated infants who underwent therapeutic cooling at our institution completed brain magnetic resonance venography after rewarming...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/27599834/case-report-of-a-central-venous-access-device-associated-thrombosis-with-aortic-embolism-in-a-preterm-infant
#15
Marlene Biermayr, Barbara Brunner, Kathrin Maurer, Rudolf Trawoeger, Ursula Kiechl-Kohlendorfer, Vera Neubauer
BACKGROUND: Thrombosis in neonates is commonly a central venous access device (CVAD) associated complication. Furthermore, a patent foramen ovale (PFO) is frequently seen in preterm infants. Even though a coincidence of both is not unusual, detaching of the thrombus and organisation of an aortic embolism has not been described until now. Treatment recommendations of CVAD-associated thrombosis in neonates do not consider frequently seen complications of preterm infants e.g. intraventricular haemorrhage...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27576316/successful-endovascular-management-of-massive-pansinus-thrombosis-case-report-and-review-of-literature
#16
REVIEW
Alexander Drofa, Evgueni Kouznetsov, Stephen Tomek, Matthew Wiisanen, Michael Manchak, Timothy Lindley, Steven Mitchell, Ferdinand Hui, Dane Breker
Cerebral sinus venous thrombosis (CSVT) is a recognized cause of childhood and neonatal stroke. More than 50% of neonates have a poor outcome, and mortality is high. Coma is a predictor of death in neonatal CSVT. We present the case of a 9-day-old infant, who presented in coma and was treated successfully with a combination of mechanical thrombectomy using the MindFrame System via the right jugular vein, local infusion of recombinant tissue plasminogen activator and abciximab, as well as anticoagulation. In this case, aggressive thrombectomy and thrombolysis achieved complete neurologic restoration safely and quickly...
2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27396366/cerebral-sinovenous-thrombosis-in-neonates-and-children
#17
COMMENT
Melissa G Chung
Investigators from Erasmus University Hospital in Belgium and Gustave-Dron Hospital and Roger-Salengro Hospital in France studied the clinical and neuroradiologic characteristics of cerebral sinovenous thrombosis (CSVT) in neonates and children.
March 2016: Pediatric Neurology Briefs
https://www.readbyqxmd.com/read/27183555/a-rare-cause-of-retinal-artery-occlusion-in-severe-hypernatremic-dehydration-in-newborns
#18
Pinar Altiaylik Ozer, Emrah Utku Kabatas, Bengi Ece Kurtul, Dilek Dilli, Aysegul Zenciroglu, Nurullah Okumus
Neonatal hypernatremia is an important electrolyte disorder that may have serious complications. It may be a rare and underdiagnosed cause of venous and arterial thrombosis, leading to severe brain damage by cerebral edema and intracranial hemorrhage. Here, the authors present a case of bilateral central retinal artery occlusion in a newborn with severe hypernatremic dehydration who is found to be normal in terms of other causes of retinal arterial thromboembolization. [Ophthalmic Surg Lasers Imaging Retina...
May 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27053184/pediatric-thromboembolism-in-japan
#19
Kenichi Tetsuhara, Akira Ishiguro, Nobuaki Michihata, Sonoko Sensaki, Hisaya Nakadate, Yui Kimura, Daisuke Tomizawa, Kimikazu Matsumoto
OBJECTIVES: To investigate the clinical and epidemiologic characteristics of thromboembolism in Japanese children. METHODS: Clinical data of 77 patients with thromboembolism from a national tertiary pediatric care center were reviewed. RESULTS: Incidence of thromboembolism was calculated to be 15 per 10,000 hospital admissions. Infants younger than one year of age made up the largest age group (25 patients, including nine neonates younger than 30 d)...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27025499/cerebral-sinovenous-thrombosis-csvt-in-children-what-the-pediatric-radiologists-need-to-know
#20
REVIEW
Chiara Carducci, Giovanna Stefania Colafati, Lorenzo Figà-Talamanca, Daniela Longo, Tommaso Lunardi, Francesco Randisi, Bruno Bernardi
Cerebral sinovenous thrombosis (CSVT) is a relatively uncommon and potentially life-threatening condition in childhood, occurring in various clinical settings. Nowadays, however, it is increasingly diagnosed as related to many causes, likely due to greater clinical awareness and improvement of neuroradiologic techniques. The prompt diagnosis is an important goal to significantly reduce the risk of acute complications and long-term sequelae. The purpose of this narrative overview is to provide a useful educational tool in daily clinical practice for radiologists with a broad perspective of CSVT including a discussion of more common potential pitfalls related to misinterpretation of images in children...
May 2016: La Radiologia Medica
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