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Hyperpolarized MRI

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https://www.readbyqxmd.com/read/27884465/crossing-the-chasm-s-demonstrating-the-clinical-value-of-hyperpolarized-gas-mri
#1
EDITORIAL
Bastiaan Driehuys
No abstract text is available yet for this article.
November 21, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27882307/metabolic-imaging-in-prostate-cancer-where-we-are
#2
REVIEW
Claudia Testa, Cristian Pultrone, David Neil Manners, Riccardo Schiavina, Raffaele Lodi
In recent years, the development of diagnostic methods based on metabolic imaging has been aimed at improving diagnosis of prostate cancer (PCa) and perhaps at improving therapy. Molecular imaging methods can detect specific biological processes that are different when detected within cancer cells relative to those taking place in surrounding normal tissues. Many methods are sensitive to tissue metabolism; among them, positron emission tomography (PET) and magnetic resonance spectroscopic imaging (MRSI) are widely used in clinical practice and clinical research...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27862799/a-hyperpolarizable-1-h-magnetic-resonance-probe-for-signal-detection-15%C3%A2-minutes-after-spin-polarization-storage
#3
Soumya S Roy, Philip Norcott, Peter J Raynern, Gary G R Green, Simon B Duckett
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are two extremely important techniques with applications ranging from molecular structure determination to human imaging. However, in many cases the applicability of NMR and MRI are limited by inherently poor sensitivity and insufficient nuclear spin lifetime. Here we demonstrate a cost-efficient and fast technique that tackles both issues simultaneously. We use the signal amplification by reversible exchange (SABRE) technique to hyperpolarize the target (1) H nuclei and store this polarization in long-lived singlet (LLS) form after suitable radiofrequency (rf) pulses...
November 15, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27791285/signal-to-noise-ratio-t2-and-t2-for-hyperpolarized-helium-3-mri-of-the-human-lung-at-three-magnetic-field-strengths
#4
Peter Komlosi, Talissa A Altes, Kun Qing, Karen E Mooney, G Wilson Miller, Jaime F Mata, Eduard E de Lange, William A Tobias, Gordon D Cates, John P Mugler
PURPOSE: To evaluate T2 , T2*, and signal-to-noise ratio (SNR) for hyperpolarized helium-3 ((3) He) MRI of the human lung at three magnetic field strengths ranging from 0.43T to 1.5T. METHODS: Sixteen healthy volunteers were imaged using a commercial whole body scanner at 0.43T, 0.79T, and 1.5T. Whole-lung T2 values were calculated from a Carr-Purcell-Meiboom-Gill spin-echo-train acquisition. T2* maps and SNR were determined from dual-echo and single-echo gradient-echo images, respectively...
October 28, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27779334/simultaneous-in-vivo-assessment-of-cardiac-and-hepatic-metabolism-in-the-diabetic-rat-using-hyperpolarized-mrs
#5
Lydia M Le Page, Daniel R Ball, Vicky Ball, Michael S Dodd, Jack J Miller, Lisa C Heather, Damian J Tyler
Understanding and assessing diabetic metabolism is vital for monitoring disease progression and improving treatment of patients. In vivo assessments, using MRI and MRS, provide non-invasive and accurate measurements, and the development of hyperpolarized (13) C spectroscopy in particular has been demonstrated to provide valuable metabolic data in real time. Until now, studies have focussed on individual organs. However, diabetes is a systemic disease affecting multiple tissues in the body. Therefore, we have developed a technique to simultaneously measure metabolism in both the heart and liver during a single acquisition...
October 25, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27766840/hyperpolarized-multi-metal-13-c-sensors-for-mri
#6
Anurag Mishra, Giorgio Pariani, Thomas Oerther, Markus Schwaiger, Gil Gregor Westmeyer
We introduce hyperpolarizable (13)C-labelled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through Dynamic Nuclear Polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable (13)C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples...
October 21, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27734519/a-hybrid-multibreath-wash-in-wash-out-lung-function-quantification-scheme-in-human-subjects-using-hyperpolarized-3-he-mri-for-simultaneous-assessment-of-specific-ventilation-alveolar-oxygen-tension-oxygen-uptake-and-air-trapping
#7
Hooman Hamedani, Stephen Kadlecek, Yi Xin, Sarmad Siddiqui, Heather Gatens, Joseph Naji, Masaru Ishii, Maurizio Cereda, Milton Rossman, Rahim Rizi
PURPOSE: To present a method for simultaneous acquisition of alveolar oxygen tension (PA O2 ), specific ventilation (SV), and apparent diffusion coefficient (ADC) of hyperpolarized (HP) gas in the human lung, allowing reinterpretation of the PA O2 and SV maps to produce a map of oxygen uptake (R). METHOD: An imaging scheme was designed with a series of identical normoxic HP gas wash-in breaths to measure ADC, SV, PA O2 , and R in less than 2 min. Signal dynamics were fit to an iterative recursive model that regionally solved for these parameters...
October 13, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27731948/ultrashort-echo-time-mri-biomarkers-of-asthma
#8
Khadija Sheikh, Fumin Guo, Dante P I Capaldi, Alexei Ouriadov, Rachel L Eddy, Sarah Svenningsen, Grace Parraga
PURPOSE: To develop and assess ultrashort echo-time (UTE) magnetic resonance imaging (MRI) biomarkers of lung function in asthma patients. MATERIALS AND METHODS: Thirty participants including 13 healthy volunteers and 17 asthmatics provided written informed consent to UTE and pulmonary function tests in addition to hyperpolarized-noble-gas 3T MRI and computed tomography (CT) for asthmatics only. The difference in MRI signal-intensity (SI) across four lung volumes (full-expiration, functional-residual-capacity [FRC], FRC+1L, and full-inspiration) was determined on a voxel-by-voxel basis to generate dynamic proton-density (DPD) maps...
October 12, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27717759/noncystic-fibrosis-bronchiectasis-regional-abnormalities-and-response-to-airway-clearance-therapy-using-pulmonary-functional-magnetic-resonance-imaging
#9
Sarah Svenningsen, Fumin Guo, David G McCormack, Grace Parraga
RATIONALE AND OBJECTIVES: Evidence-based treatment and management for patients with bronchiectasis remain challenging. There is a need for regional disease measurements as focal distribution of disease is common. Our objective was to evaluate the ability of magnetic resonance imaging (MRI) to detect regional ventilation impairment and response to airway clearance therapy (ACT) in patients with noncystic fibrosis (CF) bronchiectasis, providing a new way to objectively and regionally evaluate response to therapy...
October 4, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27711999/nmr-hyperpolarization-techniques-of-gases
#10
REVIEW
Danila A Barskiy, Aaron M Coffey, Panayiotis Nikolaou, Dmitry M Mikhaylov, Boyd M Goodson, Rosa T Branca, George J Lu, Mikhail G Shapiro, Ville-Veikko Telkki, Vladimir V Zhivonitko, Igor V Koptyug, Oleg G Salnikov, Kirill V Kovtunov, Valerii I Bukhtiyarov, Matthew S Rosen, Michael J Barlow, Shahideh Safavi, Ian P Hall, Leif Schröder, Eduard Y Chekmenev
Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection...
October 6, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27707585/the-role-of-hyperpolarized-129-xenon-in-mr-imaging-of-pulmonary-function
#11
Lukas Ebner, Jeff Kammerman, Bastiaan Driehuys, Mark L Schiebler, Robert V Cadman, Sean B Fain
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium ((3)He) and xenon ((129)Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available (129)Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community...
September 16, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27693965/dissolution-dynamic-nuclear-polarization-capability-study-with-fluid-path
#12
Ronja M Malinowski, Kasper W Lipsø, Mathilde H Lerche, Jan H Ardenkjær-Larsen
Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer...
September 22, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27689918/treatment-response-of-ethyl-pyruvate-in-a-mouse-model-of-chronic-obstructive-pulmonary-disease-studied-by-hyperpolarized-129-xe-mri
#13
Atsuomi Kimura, Yukiko Yamauchi, Shota Hodono, Neil James Stewart, Osamu Hosokawa, Yu Hagiwara, Hirohiko Imai, Hideaki Fujiwara
PURPOSE: The purpose of this work was to investigate disease progression and treatment response in a murine model of chronic obstructive pulmonary disease (COPD) using a preclinical hyperpolarized (129) Xe (HPXe) magnetic resonance imaging (MRI) strategy. METHODS: COPD phenotypes were induced in 32 mice by 10 weeks of exposure to cigarette smoke (CS) and lipopolysaccharide (LPS). Efficacy of ethyl pyruvate (EP), an anti-inflammatory drug, was investigated by administering EP to 16 of the 32 mice after 6 weeks of CS and LPS exposure...
September 30, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27670826/hyperpolarized-13-c-15-n2-urea-mri-for-assessment-of-the-urea-gradient-in-the-porcine-kidney
#14
Esben S S Hansen, Neil J Stewart, Jim M Wild, Hans Stødkilde-Jørgensen, Christoffer Laustsen
PURPOSE: A decline in cortico-medullary osmolality gradient of the kidney may serve as an early indicator of pathological disruption of the tubular reabsorption process. The purpose of this study was to investigate the feasibility of hyperpolarized (13) C,(15) N2 -urea MRI as a biomarker of renal function in healthy porcine kidneys resembling the human physiology. METHODS: Five healthy female Danish domestic pigs (weight 30 kg) were scanned at 3 Tesla (T) using a (13) C 3D balanced steady-state MR pulse sequence following injection of hyperpolarized (13) C,(15) N2 -urea via a femoral vein catheter...
December 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27662575/hyperpolarized-129xenon-magnetic-resonance-imaging-to-quantify-regional-ventilation-differences-in-mild-to-moderate-asthma-a-prospective-comparison-between-semiautomated-ventilation-defect-percentage-calculation-and-pulmonary-function-tests
#15
Lukas Ebner, Mu He, Rohan S Virgincar, Timothy Heacock, Suryanarayanan S Kaushik, Matthew S Freemann, H Page McAdams, Monica Kraft, Bastiaan Driehuys
OBJECTIVES: The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). MATERIALS AND METHODS: This single-center, Health Insurance Portability and Accountability Act-compliant prospective study was approved by our institutional review board. Thirty subjects (10 young asthmatic patients, 26 ± 6 years; 3 males, 7 females; 10 older asthmatic patients, 64 ± 6 years; 3 males, 7 females; 10 healthy controls) were enrolled...
September 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27643815/an-expanded-palette-of-xenon-129-nmr-biosensors
#16
Yanfei Wang, Ivan J Dmochowski
Molecular imaging holds considerable promise for elucidating biological processes in normal physiology as well as disease states, by determining the location and relative concentration of specific molecules of interest. Proton-based magnetic resonance imaging ((1)H MRI) is nonionizing and provides good spatial resolution for clinical imaging but lacks sensitivity for imaging low-abundance (i.e., submicromolar) molecular markers of disease or environments with low proton densities. To address these limitations, hyperpolarized (hp) (129)Xe NMR spectroscopy and MRI have emerged as attractive complementary methodologies...
October 18, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27635086/hyperpolarized-13c-metabolic-mri-of-the-human-heart-initial-experience
#17
Charles H Cunningham, Justin Y Lau, Albert P Chen, Benjamin J Geraghty, William J Perks, Idan Roifman, Graham A Wright, Kim A Connelly
RATIONALE: Altered cardiac energetics is known to play an important role in the progression towards heart failure. A non-invasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. OBJECTIVE: To demonstrate the first hyperpolarized (13)C metabolic magnetic resonance imaging (MRI) of the human heart. METHODS AND RESULTS: Four healthy subjects underwent conventional proton cardiac MRI followed by (13)C imaging and spectroscopic acquisition immediately following intravenous administration of a 0...
September 15, 2016: Circulation Research
https://www.readbyqxmd.com/read/27617823/using-hyperpolarized-129-xe-mri-to-quantify-the-pulmonary-ventilation-distribution
#18
Mu He, Bastiaan Driehuys, Loretta G Que, Yuh-Chin T Huang
RATIONALE AND OBJECTIVES: Ventilation heterogeneity is impossible to detect with spirometry. Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled (129)Xe magnetic resonance imaging (MRI). To date, such images have been quantified primarily based on ventilation defects. Here, we introduce a robust means to transform (129)Xe MRI scans such that the underlying ventilation distribution and its heterogeneity can be quantified. MATERIALS AND METHODS: Quantitative (129)Xe ventilation MRI was conducted in 12 younger (24...
September 8, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27548739/renal-ischemia-and-reperfusion-assessment-with-three-dimensional-hyperpolarized-13-c-15-n2-urea
#19
Per Mose Nielsen, Esben Søvsø Szocska Hansen, Thomas Stokholm Nørlinger, Rikke Nørregaard, Lotte Bonde Bertelsen, Hans Stødkilde Jørgensen, Christoffer Laustsen
PURPOSE: The aim of this work was to investigate whether hyperpolarized (13) C,(15) N2 -urea can be used as an imaging marker of renal injury in renal unilateral ischemic reperfusion injury (IRI), given that urea is correlated with the renal osmotic gradient, which describes the renal function. METHODS: Hyperpolarized three-dimensional balanced steady-state (13) C magnetic resonance imaging (MRI) experiments alongside kidney function parameters and quantitative polymerase chain reaction measurements were performed in rats subjected to unilateral renal ischemia for 60-minute and 24-hour reperfusion...
November 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27547777/developing-hyperpolarized-silicon-particles-for-in-vivo-mri-targeting-of-ovarian-cancer
#20
Nicholas Whiting, Jingzhe Hu, Niki M Zacharias, Ganesh L R Lokesh, David E Volk, David G Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K Sood, Pratip Bhattacharya
Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging...
July 2016: Journal of Medical Imaging
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