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Hyperpolarized MRI

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https://www.readbyqxmd.com/read/28921655/fast-dynamic-ventilation-mri-of-hyperpolarized-129-xe-using-spiral-imaging
#1
Ozkan Doganay, Tahreema N Matin, Anthony Mcintyre, Brian Burns, Rolf F Schulte, Fergus V Gleeson, Daniel Bulte
PURPOSE: To develop and optimize a rapid dynamic hyperpolarized (129) Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS: Spiral k-space trajectories were designed with the number of interleaves Nint  = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of view = 15 cm. DXeV images were acquired from a gas-flow phantom to investigate the ability of Nint  = 1, 2, 4, and 8 to capture signal-time curves...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28880278/preparation-of-biogenic-gas-vesicle-nanostructures-for-use-as-contrast-agents-for-ultrasound-and-mri
#2
Anupama Lakshmanan, George J Lu, Arash Farhadi, Suchita P Nety, Martin Kunth, Audrey Lee-Gosselin, David Maresca, Raymond W Bourdeau, Melissa Yin, Judy Yan, Christopher Witte, Dina Malounda, F Stuart Foster, Leif Schröder, Mikhail G Shapiro
Gas vesicles (GVs) are a unique class of gas-filled protein nanostructures that are detectable at subnanomolar concentrations and whose physical properties allow them to serve as highly sensitive imaging agents for ultrasound and MRI. Here we provide a protocol for isolating GVs from native and heterologous host organisms, functionalizing these nanostructures with moieties for targeting and fluorescence, characterizing their biophysical properties and imaging them using ultrasound and MRI. GVs can be isolated from natural cyanobacterial and haloarchaeal host organisms or from Escherichia coli expressing a heterologous GV gene cluster and purified using buoyancy-assisted techniques...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28880161/unsupervised-segmentation-of-5d-hyperpolarized-carbon-13-mri-data-using-a-fuzzy-markov-random-field-model
#3
Ferdia A Gallagher, Charlie J Daniels
Hyperpolarized MRI with ¹³C-labelled compounds is an emerging clinical technique allowing in vivo metabolic processes to be characterized non-invasively. Accurate quantification of ¹³C data, both for clinical and research purposes, typically relies on the use of region-of-interest analysis to detect and compare regions of altered metabolism. However, it is not clear how this should be determined from the five-dimensional data produced and most standard methodologies are unable to exploit the multidimensional nature of the data...
September 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28860333/using-hyperpolarized-129-xe-mri-to-quantify-regional-gas-transfer-in-idiopathic-pulmonary-fibrosis
#4
Jennifer M Wang, Scott H Robertson, Ziyi Wang, Mu He, Rohan S Virgincar, Geoffry M Schrank, Rose Marie Smigla, Thomas G O'Riordan, John Sundy, Lukas Ebner, Craig R Rackley, Page McAdams, Bastiaan Driehuys
BACKGROUND: Assessing functional impairment, therapeutic response and disease progression in patients with idiopathic pulmonary fibrosis (IPF) continues to be challenging. Hyperpolarized (129)Xe MRI can address this gap through its unique capability to image gas transfer three-dimensionally from airspaces to interstitial barrier tissues to red blood cells (RBCs). This must be validated by testing the degree to which it correlates with pulmonary function tests (PFTs) and CT scores, and its spatial distribution reflects known physiology and patterns of disease...
August 31, 2017: Thorax
https://www.readbyqxmd.com/read/28841293/heading-toward-macromolecular-and-nanosized-bioresponsive-mri-probes-for-successful-functional-imaging
#5
Goran Angelovski
The quest for bioresponsive or smart contrast agents (SCAs) in molecular imaging, in particular magnetic resonance imaging (MRI), is progressively increasing since they allow for the monitoring of essential biological processes on molecular and cellular levels in a dynamic fashion. These are offshoot molecules of common contrast agents that are sensitive to biochemical changes in their environment, capable of reporting on such changes by inducing MRI signal alteration. Various mechanistic approaches and different types of SCAs have been developed in order to visualize desired processes, using diverse imaging protocols and methods...
August 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28840759/the-potential-of-hyperpolarized-13-c-magnetic-resonance-spectroscopy-to-monitor-the-effect-of-combretastatin-based-vascular-disrupting-agents
#6
Ane B Iversen, Morten Busk, Lotte B Bertelsen, Christoffer Laustsen, Ole L Munk, Thomas Nielsen, Thomas R Wittenborn, Johan Bussink, Jasper Lok, Hans Stødkilde-Jørgensen, Michael R Horsman
BACKGROUND: Targeting tumor vasculature with vascular disrupting agents (VDAs) results in substantial cell death that precede tumor shrinkage. Here, we investigate the potential of hyperpolarized magnetic resonance spectroscopy (HPMRS) to monitor early metabolic changes associated with VDA treatment. METHODS: Mice bearing C3H mammary carcinomas were treated with the VDAs combretastatin-A4-phosphate (CA4P) or the analog OXi4503, and HPMRS was performed following [1-(13)C]pyruvate administration...
August 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28801662/nanometer-size-silicon-particles-for-hyperpolarized-mri
#7
Grzegorz Kwiatkowski, Fabian Jähnig, Jonas Steinhauser, Patrick Wespi, Matthias Ernst, Sebastian Kozerke
Hyperpolarized silicon particles have been shown to exhibit long spin-lattice relaxation times at room temperature, making them interesting as novel MRI probes. Demonstrations of hyperpolarized silicon particle imaging have focused on large micron size particles (average particle size (APS) = 2.2 μm) as they have, to date, demonstrated much larger polarizations than nanoparticles. We show that also much smaller silicon-29 particles (APS = 55 ± 12 nm) can be hyperpolarized with superior properties...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719100/deuteration-of-hyperpolarized-%C3%A2-%C3%A2-c-labelled-zymonic-acid-enables-sensitivity-enhanced-dynamic-mri-of-ph
#8
Christian Hundshammer, Stephan Düwel, Simone Köcher, Malte Gersch, Benedikt Feuerecker, Christoph Scheurer, Axel Haase, Steffen J Glaser, Markus Schwaiger, Franz Schilling
Aberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug delivery systems. We recently introduced hyperpolarized zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10,000-fold NMR signal enhancement. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA (ZAd)...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28716678/cancer-recurrence-monitoring-using-hyperpolarized-1-13-c-pyruvate-metabolic-imaging-in-murine-breast-cancer-model
#9
Peter J Shin, Zihan Zhu, Roman Camarda, Robert A Bok, Alicia Y Zhou, John Kurhanewicz, Andrei Goga, Daniel B Vigneron
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial (1)H MRI and hyperpolarized [1-(13)C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion...
July 15, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28708304/hyperpolarized-13-c-magnetic-resonance-evaluation-of-renal-ischemia-reperfusion-injury-in-a-murine-model
#10
Celine Baligand, Hecong Qin, Aisha True-Yasaki, Jeremy W Gordon, Cornelius von Morze, Justin Delos Santos, David M Wilson, Robert Raffai, Patrick M Cowley, Anthony J Baker, John Kurhanewicz, David H Lovett, Zhen Jane Wang
Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease (CKD). Persistent oxidative stress and mitochondrial dysfunction are implicated across diverse forms of AKI and in the transition to CKD. In this study, we applied hyperpolarized (HP) (13) C dehydroascorbate (DHA) and (13) C pyruvate magnetic resonance spectroscopy (MRS) to investigate the renal redox capacity and mitochondrial pyruvate dehydrogenase (PDH) activity, respectively, in a murine model of AKI at baseline and 7 days after unilateral ischemia reperfusion injury (IRI)...
July 14, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28682000/hyperpolarizing-water-with-para-hydrogen
#11
Sören Lehmkuhl, Meike Emondts, Lukas Schubert, Peter Spannring, Jürgen Klankermayer, Bernhard Blümich, Philipp Schleker
Studies of water based systems are of fundamental interest for NMR (Nuclear Magnetic Resonance) and Magnetic Resonance Imaging (MRI) as it is the most abundant and important medium for global living. Hence, increasing the polarization of water and dissolved compounds is particularly attractive for biomedical applications such as investigations of intermolecular interactions and metabolite structures as well as for imaging purposes. In this work, we show a new approach based on para enriched hydrogen (p-H2) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed...
July 6, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28681470/spatial-fuzzy-c-means-thresholding-for-semiautomated-calculation-of-percentage-lung-ventilated-volume-from-hyperpolarized-gas-and-1-h-mri
#12
Paul J C Hughes, Felix C Horn, Guilhem J Collier, Alberto Biancardi, Helen Marshall, Jim M Wild
PURPOSE: To develop an image-processing pipeline for semiautomated (SA) and reproducible analysis of hyperpolarized gas lung ventilation and proton anatomical magnetic resonance imaging (MRI) scan pairs. To compare results from the software for total lung volume (TLV), ventilated volume (VV), and percentage lung ventilated volume (%VV) calculation to the current manual "basic" method and a K-means segmentation method. MATERIALS AND METHODS: Six patients were imaged with hyperpolarized (3) He and same-breath lung (1) H MRI at 1...
July 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28653507/t1-nuclear-magnetic-relaxation-dispersion-of-hyperpolarized-sodium-and-cesium-hydrogencarbonate-13-c
#13
Francisco M Martínez-Santiesteban, Thien Phuoc Dang, Heeseung Lim, Albert P Chen, Timothy J Scholl
In vivo pH mapping in tissue using hyperpolarized hydrogencarbonate-(13) C has been proposed as a method to study tumor growth and treatment and other pathological conditions related to pH changes. The finite spin-lattice relaxation times (T1 ) of hyperpolarized media are a significant limiting factor for in vivo imaging. Relaxation times can be measured at standard magnetic fields (1.5 T, 3.0 T etc.), but no such data are available at low fields, where T1 values can be significantly shorter. This information is required to determine the potential loss of polarization as the agent is dispensed and transported from the polarizer to the MRI scanner...
September 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28651245/high-resolution-hyperpolarized-in-vivo-metabolic-13-c-spectroscopy-at-low-magnetic-field-48-7mt-following-murine-tail-vein-injection
#14
Aaron M Coffey, Matthew A Feldman, Roman V Shchepin, Danila A Barskiy, Milton L Truong, Wellington Pham, Eduard Y Chekmenev
High-resolution (13)C NMR spectroscopy of hyperpolarized succinate-1-(13)C-2,3-d2 is reported in vitro and in vivo using a clinical-scale, biplanar (80cm-gap) 48.7mT permanent magnet with a high homogeneity magnetic field. Non-localized (13)C NMR spectra were recorded at 0.52MHz resonance frequency over the torso of a tumor-bearing mouse every 2s. Hyperpolarized (13)C NMR signals with linewidths of ∼3Hz (corresponding to ∼6ppm) were recorded in vitro (2mL in a syringe) and in vivo (over a mouse torso). Comparison of the full width at half maximum (FWHM) for (13)C NMR spectra acquired at 48...
August 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28646735/hyperpolarized-helium-3-magnetic-resonance-lung-imaging-of-non-sedated-infants-and-young-children-a-proof-of-concept-study
#15
Talissa A Altes, Craig H Meyer, Jaime F Mata, Deborah K Froh, Alix Paget-Brown, W Gerald Teague, Sean B Fain, Eduard E de Lange, Kai Ruppert, Martyn C Botfield, Mac A Johnson, John P Mugler
PURPOSE: To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. MATERIALS AND METHODS: HHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice. RESULTS: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained...
May 10, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28645458/pulmonary-3-he-magnetic-resonance-imaging-biomarkers-of-regional-airspace-enlargement-in-alpha-1-antitrypsin-deficiency
#16
Eric Lessard, Heather M Young, Anurag Bhalla, Damien Pike, Khadija Sheikh, David G McCormack, Alexei Ouriadov, Grace Parraga
RATIONALE AND OBJECTIVES: Thoracic x-ray computed tomography (CT) and hyperpolarized (3)He magnetic resonance imaging (MRI) provide quantitative measurements of airspace enlargement in patients with emphysema. For patients with panlobular emphysema due to alpha-1 antitrypsin deficiency (AATD), sensitive biomarkers of disease progression and response to therapy have been difficult to develop and exploit, especially those biomarkers that correlate with outcomes like quality of life. Here, our objective was to generate and compare CT and diffusion-weighted inhaled-gas MRI measurements of emphysema including apparent diffusion coefficient (ADC) and MRI-derived mean linear intercept (Lm) in patients with AATD, chronic obstructive pulmonary disease (COPD) ex-smokers, and elderly never-smokers...
June 20, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28644918/heterogeneous-microtesla-sabre-enhancement-of-15-n-nmr-signals
#17
Kirill V Kovtunov, Larisa M Kovtunova, Max E Gemeinhardt, Andrey V Bukhtiyarov, Jonathan Gesiorski, Valerii I Bukhtiyarov, Eduard Y Chekmenev, Igor V Koptyug, Boyd M Goodson
The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of (15) N NMR signals in (15) N-pyridine at 9...
August 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28627764/a-simple-route-to-strong-carbon-13-nmr-signals-detectable-for-several-minutes
#18
Soumya S Roy, Philip Norcott, Peter J Rayner, Gary G R Green, Simon B Duckett
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in (13) C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime...
August 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28609572/achieving-high-levels-of-nmr-hyperpolarization-in-aqueous-media-with-minimal-catalyst-contamination-using-sabre
#19
Wissam Iali, Alexandra M Olaru, Gary G R Green, Simon B Duckett
Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced (1) H NMR signals in a range of substrates in aqueous media. To achieve this outcome, phase-transfer catalysis is exploited, which leads to less than 1.5×10(-6)  mol dm(-3) of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline-based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. The new process has been called catalyst separated hyperpolarization through signal amplification by reversible exchange or CASH-SABRE...
August 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28596156/noninvasive-interrogation-of-cancer-metabolism-with-hyperpolarized-13-c-mri
#20
REVIEW
Andrew Cho, Justin Y C Lau, Benjamin J Geraghty, Charles H Cunningham, Kayvan R Keshari
This review will highlight recent advances in hyperpolarized (13)C MR spectroscopic imaging, which can be used to noninvasively interrogate tumor metabolism. After providing an overview of MR and hyperpolarization, we will discuss the latest advances in data acquisition techniques. Next, we will shift our focus to hyperpolarized probe design and provide an overview of the latest hyperpolarized (13)C MR spectroscopic imaging probes developed in the last several years.
August 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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