K Donato, M C Medori, A Macchia, S Cecchin, M R Ceccarini, T Beccari, V Gatta, L Stuppia, V Benfatti, L Dalla Ragione, P Chiurazzi C Micheletti, K Dhuli, G Madeo, G Bonetti, G Marceddu, M Bertelli
OBJECTIVE: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by an intense fear of gaining weight, a relentless pursuit of thinness, and a distorted body image. Recent research highlights the substantial contribution of genetics to AN's etiology, with genes like BDNF, SLC6A4, and DRD2 implicated. However, a comprehensive genetic test for AN diagnosis is lacking. This study aims to elucidate the biological foundations of AN, examining variants in genes associated with syndromic forms, rare variants in AN patients, and candidate genes from GWAS studies, murine models, or established molecular pathways...
December 2023: European Review for Medical and Pharmacological Sciences